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Search of human proteins with 154240686
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo
sapiens]
(1430 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens] 2867 0.0
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens] 514 e-145
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 301 4e-81
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 286 8e-77
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 282 1e-75
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 210 7e-54
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 210 7e-54
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 166 1e-40
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 157 7e-38
gi|153791377 apoptosis-inducing protein D [Homo sapiens] 129 3e-29
gi|13375827 phafin 2 [Homo sapiens] 124 6e-28
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 99 3e-20
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 99 4e-20
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 92 3e-18
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 91 1e-17
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 91 1e-17
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 89 4e-17
gi|71274148 pleckstrin homology domain containing, family G (wit... 87 9e-17
gi|47717106 zinc finger, FYVE domain containing 9 isoform 3 [Hom... 86 3e-16
gi|157426866 zinc finger, FYVE domain containing 16 [Homo sapiens] 86 3e-16
gi|157426864 zinc finger, FYVE domain containing 16 [Homo sapiens] 86 3e-16
gi|47717112 zinc finger, FYVE domain containing 9 isoform 1 [Hom... 85 6e-16
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi... 84 7e-16
gi|6552337 zinc finger, FYVE domain containing 9 isoform 2 [Homo... 84 1e-15
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 82 3e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 82 3e-15
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 81 8e-15
gi|38679954 active breakpoint cluster region-related protein is... 80 2e-14
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like... 79 4e-14
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 79 4e-14
>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
Length = 1430
Score = 2867 bits (7432), Expect = 0.0
Identities = 1430/1430 (100%), Positives = 1430/1430 (100%)
Query: 1 MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLK 60
MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLK
Sbjct: 1 MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLK 60
Query: 61 TSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKL 120
TSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKL
Sbjct: 61 TSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKL 120
Query: 121 GHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLE 180
GHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLE
Sbjct: 121 GHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLE 180
Query: 181 EELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHS 240
EELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHS
Sbjct: 181 EELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHS 240
Query: 241 CHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGP 300
CHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGP
Sbjct: 241 CHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGP 300
Query: 301 LEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINK 360
LEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINK
Sbjct: 301 LEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINK 360
Query: 361 ISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDK 420
ISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDK
Sbjct: 361 ISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDK 420
Query: 421 DSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQM 480
DSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQM
Sbjct: 421 DSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQM 480
Query: 481 QKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNH 540
QKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNH
Sbjct: 481 QKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNH 540
Query: 541 LQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK 600
LQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK
Sbjct: 541 LQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK 600
Query: 601 PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTG 660
PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTG
Sbjct: 601 PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTG 660
Query: 661 HLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAE 720
HLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAE
Sbjct: 661 HLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAE 720
Query: 721 SLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNS 780
SLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNS
Sbjct: 721 SLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNS 780
Query: 781 SSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINS 840
SSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINS
Sbjct: 781 SSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINS 840
Query: 841 SDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDA 900
SDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDA
Sbjct: 841 SDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDA 900
Query: 901 VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKG 960
VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKG
Sbjct: 901 VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKG 960
Query: 961 PYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIP 1020
PYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIP
Sbjct: 961 PYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIP 1020
Query: 1021 QYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGH 1080
QYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGH
Sbjct: 1021 QYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGH 1080
Query: 1081 HEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKV 1140
HEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKV
Sbjct: 1081 HEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKV 1140
Query: 1141 RKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDE 1200
RKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDE
Sbjct: 1141 RKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDE 1200
Query: 1201 ADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKY 1260
ADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKY
Sbjct: 1201 ADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKY 1260
Query: 1261 GLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI 1320
GLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI
Sbjct: 1261 GLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI 1320
Query: 1321 PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLL 1380
PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLL
Sbjct: 1321 PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLL 1380
Query: 1381 GFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL 1430
GFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL
Sbjct: 1381 GFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL 1430
>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
Length = 1462
Score = 514 bits (1324), Expect = e-145
Identities = 342/894 (38%), Positives = 495/894 (55%), Gaps = 69/894 (7%)
Query: 574 LPFSGNPEFLKSVTVSSNSEPSTALTKPRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSM 633
LP SG V + + + KP KS ++ +E P K KK+SFK+ L++
Sbjct: 601 LPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLIES-DSPDKYKKKKSSFKRFLAL 659
Query: 634 KLSICFMKSDFQKFWSKSSQLGDTTTGHLS-SGEQKGIESDWQGLLVGEEKRSKPIKAYS 692
F K K + ++ S G + +E D + L + +S+ K +
Sbjct: 660 T----FKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRA 715
Query: 693 TENYSLESQKKRKKSRGQTSAANGLRAESLDDQMLSRESSSQAPYKSVTSLCAPEYENIR 752
+E+ S + K +G + R ES +D+ SR P S+ P +
Sbjct: 716 SESPSSLIFYRDGKRKGVPFSRTVSRVESFEDR--SRPPFLPLPLTKPRSISFPSADT-S 772
Query: 753 HYEEIP----EYENLPF-------IMAIRKTQELEWQNSSSMEDADA-------NVYEVE 794
YE IP +YEN+ A K E + + S+ + D N +E +
Sbjct: 773 DYENIPAMNSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESK 832
Query: 795 EPYEAPDGQLQLGPRHQHS--SSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSESSK 852
+ D + ++ SS A +E DL SDEE+ SS+E+D +S
Sbjct: 833 QQSADQDAESAYTEPYKVCPISSAAPKE--------DLTSDEEQ--RSSEEEDSASR--- 879
Query: 853 GEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQL---G 909
DP + E +S+ IA+E++SSEK +V++L+ L++DF AV A + G
Sbjct: 880 ---DPSVTHKVEG---QSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEG 933
Query: 910 KPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTY 969
+ + L Q L LP +++L++ +L+ELEER+ +W QQ++AD+F+ + ++T+
Sbjct: 934 RDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWESQQKVADVFLAREQGFDHHATH 993
Query: 970 IKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDY 1029
I +FD+ + LL E C +P AA VREFE S + + KH LL+ VQR+ QY++LLTDY
Sbjct: 994 ILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDY 1053
Query: 1030 LKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRV 1089
L NL D+ +Y +TQ AL+++ +V + AND+M+QG+N QKL+ I++S+ G +++QPGR
Sbjct: 1054 LNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGRE 1113
Query: 1090 FLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQ 1149
FLKEG LMK++ K +PR FL ND LLYT P + G Y+L N L++A MKV +P E
Sbjct: 1114 FLKEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVP 1173
Query: 1150 NELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEV 1209
LKIE+ E +LSASS ERDEW +SRA+ E K + S+ E +E +
Sbjct: 1174 YALKIETSESCLMLSASSCAERDEWYGCLSRALPEDYKAQALAAFHHSV-----EIRERL 1228
Query: 1210 S-PLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQ 1268
LG + P +P T MCM C +F+LT RRHHC ACGKIVC+ CS NKY L YLK++
Sbjct: 1229 GVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDR 1288
Query: 1269 PARVCEHCFQELQK-------LDHQHSPRIGSP-GNHKSPSSALSSVLHSI-PSG-RKQK 1318
A+VC+ CF EL+K L + + P + + SA SSV SI PS +KQK
Sbjct: 1289 MAKVCDGCFGELKKRGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQK 1348
Query: 1319 KIPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQP 1378
K+P+AL EV+A+ E S++SGYL R K K+ WK WFVIK KVLYTY ASED ALES P
Sbjct: 1349 KVPSALTEVAASGEGSAISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMP 1408
Query: 1379 LLGFTVIQVKDENSE--SKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL 1430
LLGFT+ K+E S +F L HK LFY FKAED +SAQ+WIEA ++ ++L
Sbjct: 1409 LLGFTIAPEKEEGSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDASVL 1462
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 301 bits (770), Expect = 4e-81
Identities = 200/631 (31%), Positives = 317/631 (50%), Gaps = 55/631 (8%)
Query: 808 PRHQHSSSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQ-DEDN 866
P AS G+G + EE ++ + E GE PLE +Q D+ +
Sbjct: 142 PTTDSCDGNASDSSYRTPGIGPVLPLEER---GAETETKVQERENGE-SPLELEQLDQHH 197
Query: 867 GMKS----KVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQIL 922
MK K+H IA E++ +E+ +V+ L LL F + + + P ++N+I
Sbjct: 198 EMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPA---EMVNKIF 254
Query: 923 YYLPQLYELN-RDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLD 981
+ + + + LL ELE+RM W RI DI K P+LKMY Y+K FD + L+
Sbjct: 255 SNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVK 314
Query: 982 EQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYR 1041
++ P F +VV E + C +L L+H++L+PVQRIP+Y +LL DYL+ L D+ D+
Sbjct: 315 NMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWN 374
Query: 1042 DTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSR 1101
D + +L ++ A+H+N +++ +N +KL++I L +IV P +KEG ++KL+
Sbjct: 375 DAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAA 434
Query: 1102 K--VMQPRMFFLFNDALLYTTP---VQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIES 1156
+ Q R FLFN+ LLY P + + + + + GMK+ + E Y + ++
Sbjct: 435 RNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSG 494
Query: 1157 VERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLGSKA 1216
ER+ L ASSA +++EW++A+ I+ + ++ TF + + D D ++ + LG +A
Sbjct: 495 KERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDN-DIHSEVSTAELGKRA 553
Query: 1217 PIWIPDTRATMCMICTSEF-TLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEH 1275
P WI D TMCM C F LT RRHHCRACG +VC CS K L+Y + ++VC+
Sbjct: 554 PRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKD 613
Query: 1276 CFQELQKL-DHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDS 1334
C+Q + D + R G + I S EVS N+
Sbjct: 614 CYQIISGFTDSEEKKRKG---------------ILEIESA-----------EVSGNSVVC 647
Query: 1335 SMSGYLYRSKGNKKPWKHFWFVIKNK---VLYTYAASEDVAALESQPLLGFTVIQVKDEN 1391
S Y+ +S KPW+ W VI + VLY Y A +DV A + PLLG+ V ++
Sbjct: 648 SFLQYMEKS----KPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSA 703
Query: 1392 SESKVFQLLHKNMLFYVFKAEDAHSAQKWIE 1422
F+L + + F A+ QKW++
Sbjct: 704 DLPHSFKLTQSKSV-HSFAADSEELKQKWLK 733
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 286 bits (733), Expect = 8e-77
Identities = 184/608 (30%), Positives = 302/608 (49%), Gaps = 41/608 (6%)
Query: 831 PSDEEEIINSSDEDDVSSESSKGE--PDPLEDKQDE-DNGMKSKVHHIAKEIMSSEKVFV 887
P +E + +EDD E K P PL ++Q+ + ++ KV HIA E++ +EK +V
Sbjct: 330 PGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYV 389
Query: 888 DVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRD-LLKELEERMLHW 946
L LL F + +R + +++ I + +Y ++ LL ELE+RM W
Sbjct: 390 SRLHLLDQVFCARLLEEARN--RSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEW 447
Query: 947 TEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANL 1006
RI DI K P+LKMY Y+K FD+ + L++ +++ F ++ E + C NL
Sbjct: 448 DRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNL 507
Query: 1007 ALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDN 1066
L+H++L+PVQRIP+Y LLL DYL L + D +D Q +L ++ A H+N +++ +
Sbjct: 508 TLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMER 567
Query: 1067 FQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRK--VMQPRMFFLFNDALLYTTP--- 1121
KL+++ L G +IV P + +KEG ++KLS K Q R LFND LLY P
Sbjct: 568 MHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLR 627
Query: 1122 VQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRA 1181
+ + + + + GM++++ + + +RS L A + E+ +W++AI+
Sbjct: 628 LLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINST 687
Query: 1182 IEEYAKKRITF--CPSRSLDEADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEF-TLT 1238
+ ++ + TF S + ++ D+ LG +AP I + TMCM C F ++T
Sbjct: 688 LLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSIT 747
Query: 1239 WRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHK 1298
RRHHC+ACG +VC CS + L Y N+ RVC C+ L H
Sbjct: 748 KRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVAL----------------HG 791
Query: 1299 SPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIK 1358
P S+ + H+ Q++ K+ S E+S + +L+ + K W WFV+
Sbjct: 792 VPGSSPACSQHT-----PQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVP 846
Query: 1359 NK---VLYTYAASEDVAALESQPLLGFTV--IQVKDENSESKVFQLLHKNMLFYVFKAED 1413
VLY Y A +DV A S PL+GF V + + VF++ ++ +Y F E
Sbjct: 847 ENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWY-FSPET 905
Query: 1414 AHSAQKWI 1421
++W+
Sbjct: 906 EELQRRWM 913
Score = 31.6 bits (70), Expect = 5.7
Identities = 18/59 (30%), Positives = 25/59 (42%), Gaps = 1/59 (1%)
Query: 9 KPPVAPKPKFVVANNKPAP-PPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLKTSPVRE 66
KP V PKP ++ P P PI P P + + P+ K + P P S + E
Sbjct: 158 KPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIE 216
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 282 bits (722), Expect = 1e-75
Identities = 204/648 (31%), Positives = 309/648 (47%), Gaps = 53/648 (8%)
Query: 796 PYEAPDGQLQLGPRHQHS-----SSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSES 850
P AP GQ H+ S G ++ +G P +S ++ +SSE+
Sbjct: 25 PEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEA 84
Query: 851 SKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGK 910
+ P+ +G + I +E++ +E+ +V L LL F + +R K
Sbjct: 85 WRKSCQPVTLS---GSGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARS-SK 140
Query: 911 PVIEDRILNQILYYLPQLYELNRDL-LKELEERMLHWTEQQRIADIFVKKGPYLKMYSTY 969
ED ++ I + +Y+ + L EL+ R+ WT RI D+ K P+LKMYS Y
Sbjct: 141 AFPED-VVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEY 199
Query: 970 IKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDY 1029
+K F++ LL K+P F V+ + S +L L+H++L+PVQRIP+Y LLL +Y
Sbjct: 200 VKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEY 259
Query: 1030 LKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRV 1089
++ L A D D Q AL ++ A H+N + + + Q L ++ L +IV P
Sbjct: 260 IQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNT 319
Query: 1090 FLKEGILMKLSRKVMQP--RMFFLFNDALLYTTP--VQSG-MYKLNNMLSLAGMKVRKPT 1144
L+EG ++K+S + P R FLFN+ LLY P +Q G +++ + +AGMKVR+
Sbjct: 320 LLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELM 379
Query: 1145 QEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSE 1204
+ + + +R+ L A S E W++A AI++ K+ TF + E D +
Sbjct: 380 DAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQ 439
Query: 1205 NKE-EVSPLGSKAPIWIPDTRATMCMICTSEF-TLTWRRHHCRACGKIVCQACSSNKYGL 1262
+E + LG +AP W+ D TMCM C F LT RRHHCRACG +VC CS + L
Sbjct: 440 EQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAEL 499
Query: 1263 DYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKIPA 1322
Y N+P RVC HC+ L GN +P ++ K+
Sbjct: 500 KYDDNRPNRVCLHCYAFL-------------TGN-------------VLPEAKEDKRRGI 533
Query: 1323 ALKEVSANTEDSSMSGYLYRSKGNK--KPWKHFWFVIKNK---VLYTYAASEDVAALESQ 1377
K SA + S M +L + G+K K W VI VLY YAA +D+ A S
Sbjct: 534 LEKGSSATPDQSLMCSFL-QLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSI 592
Query: 1378 PLLGFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQ 1425
PLLG+ V + +VFQL L Y FKAE +W++A +
Sbjct: 593 PLLGYQV--TVGPQGDPRVFQLQQSGQL-YTFKAETEELKGRWVKAME 637
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 210 bits (535), Expect = 7e-54
Identities = 162/583 (27%), Positives = 262/583 (44%), Gaps = 76/583 (13%)
Query: 830 LPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKS-----KVHHIAKEIMSSEK 884
L S ++ + D E E P K D+D G+ K+ HIA+E++ +E+
Sbjct: 113 LDSQVPKVTPQEEADSDVGEEPDSENTP--QKADKDAGLAQHSGPQKLLHIAQELLHTEE 170
Query: 885 VFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRD-LLKELEERM 943
+V L LL F + A I ++ I + ++ + LL EL+ R+
Sbjct: 171 TYVKRLHLLDQVFCTRLTDAG-------IPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223
Query: 944 LH-WTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPR 1002
W R+ DI K P+LKMY Y+K FD+ + L+ +++P F VV +
Sbjct: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283
Query: 1003 CANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMK 1062
C NL L+H++L+PVQR+P+Y LLL DYLK L +DA D +D + +L ++ ANH+N ++
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343
Query: 1063 QGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRK--VMQPRMFFLFNDALLYTT 1120
+ + KL+++ L G +IV P +KEG + KLS K Q R FLFN +LY
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403
Query: 1121 P---VQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEA 1177
P + + + + ++G++V+ + + I +RS L + E+ EW++
Sbjct: 404 PKLRLMGQKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQI 463
Query: 1178 ISRAIEEYAKKRITF-----------CPSRSLD---EADSENKEEVSPLGSKAPIWIP-- 1221
I IE++ + TF PS S D + S + V+ GS +
Sbjct: 464 IQATIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPR 523
Query: 1222 --------DTRATMCMICTSEF-TLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARV 1272
D C C F ++T RRHHC+ CG ++C CS K ++ +RV
Sbjct: 524 KLSSKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAE----NSRQSRV 579
Query: 1273 CEHCF----------QELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIP---------- 1312
C CF ++ D Q S G P S V +IP
Sbjct: 580 CRDCFLTQPVAPESTEKTPTADPQPSLLCG-PLRLSESGETWSEVWAAIPMSDPQVLHLQ 638
Query: 1313 ----SGRKQKKIPAALKEVSA-NTEDSSMSGYLYRSKGNKKPW 1350
GR + IP ++S + E+ SG++++ + K+ W
Sbjct: 639 GGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSW 681
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 210 bits (535), Expect = 7e-54
Identities = 162/583 (27%), Positives = 262/583 (44%), Gaps = 76/583 (13%)
Query: 830 LPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKS-----KVHHIAKEIMSSEK 884
L S ++ + D E E P K D+D G+ K+ HIA+E++ +E+
Sbjct: 113 LDSQVPKVTPQEEADSDVGEEPDSENTP--QKADKDAGLAQHSGPQKLLHIAQELLHTEE 170
Query: 885 VFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRD-LLKELEERM 943
+V L LL F + A I ++ I + ++ + LL EL+ R+
Sbjct: 171 TYVKRLHLLDQVFCTRLTDAG-------IPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223
Query: 944 LH-WTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPR 1002
W R+ DI K P+LKMY Y+K FD+ + L+ +++P F VV +
Sbjct: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283
Query: 1003 CANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMK 1062
C NL L+H++L+PVQR+P+Y LLL DYLK L +DA D +D + +L ++ ANH+N ++
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343
Query: 1063 QGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRK--VMQPRMFFLFNDALLYTT 1120
+ + KL+++ L G +IV P +KEG + KLS K Q R FLFN +LY
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403
Query: 1121 P---VQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEA 1177
P + + + + ++G++V+ + + I +RS L + E+ EW++
Sbjct: 404 PKLRLMGQKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQI 463
Query: 1178 ISRAIEEYAKKRITF-----------CPSRSLD---EADSENKEEVSPLGSKAPIWIP-- 1221
I IE++ + TF PS S D + S + V+ GS +
Sbjct: 464 IQATIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPR 523
Query: 1222 --------DTRATMCMICTSEF-TLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARV 1272
D C C F ++T RRHHC+ CG ++C CS K ++ +RV
Sbjct: 524 KLSSKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAE----NSRQSRV 579
Query: 1273 CEHCF----------QELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIP---------- 1312
C CF ++ D Q S G P S V +IP
Sbjct: 580 CRDCFLTQPVAPESTEKTPTADPQPSLLCG-PLRLSESGETWSEVWAAIPMSDPQVLHLQ 638
Query: 1313 ----SGRKQKKIPAALKEVSA-NTEDSSMSGYLYRSKGNKKPW 1350
GR + IP ++S + E+ SG++++ + K+ W
Sbjct: 639 GGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSW 681
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 166 bits (420), Expect = 1e-40
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 29/370 (7%)
Query: 871 KVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYE 930
+ + I KEI+++E+ ++ L+++ + FR AV + + ++ + + +YE
Sbjct: 535 EAYFIVKEILATERTYLKDLEVITVWFRSAVVK------EDAMPATLMTLLFSNIDPIYE 588
Query: 931 LNRDLLKELEERMLHWT---------EQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLD 981
+R L+E+E+R+ W QRI DI ++ LK +++Y + D+ + L+
Sbjct: 589 FHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELE 648
Query: 982 EQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYR 1041
+ K+ AV +EFE+ C L L +LLKP+QR+ YRLLL + DY
Sbjct: 649 KATKRCKKLEAVYKEFELQKVCY-LPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYA 707
Query: 1042 DTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSR 1101
D DAL + EV + + +N QKL ++Q L G ++ PGR F++EG L KL++
Sbjct: 708 DCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTK 767
Query: 1102 KVMQPRMFFLFNDALLYTTPVQSGM--YKLNNMLSLAGMKVRKPTQE-AYQNELKIESVE 1158
K +Q RMFFLF+D LLYT+ +G +++ +L L GM V + E + + I + +
Sbjct: 768 KGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQ 827
Query: 1159 RSFILSASSATERDEWLEAISRAIEEY--------AKKRITFC--PSRSLDEADSENKEE 1208
++ +++AS+ E+++W+ ++ AI+ A T C P RS +E E + E
Sbjct: 828 KTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESE 887
Query: 1209 VSPLGSKAPI 1218
G ++ +
Sbjct: 888 DDARGVRSSL 897
Score = 58.2 bits (139), Expect = 6e-08
Identities = 32/95 (33%), Positives = 52/95 (54%), Gaps = 3/95 (3%)
Query: 1333 DSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTVIQVKDENS 1392
++ +SGYL R N W+ W V N L+ Y +D L S PLLG++V ++ +
Sbjct: 929 ENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADG 988
Query: 1393 ESK--VFQLLHKNMLFYVFKAEDAHSAQKWIEAFQ 1425
K VF+L K+ + Y F+AE ++ ++W+E Q
Sbjct: 989 IHKDYVFKLQFKSHV-YFFRAESKYTFERWMEVIQ 1022
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 157 bits (397), Expect = 7e-38
Identities = 115/397 (28%), Positives = 202/397 (50%), Gaps = 36/397 (9%)
Query: 863 DEDNGMKS-----KVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRI 917
DED G + K + IAKE+ ++E+ ++ L+++ F+ V+ + + + +
Sbjct: 527 DEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSK------EDAMPEAL 580
Query: 918 LNQILYYLPQLYELNRDLLKELEERMLHW--------TEQQRIADIFVKKGPYLKMYSTY 969
+ I L++ + + LKE+E+R+ W + QRI D+ +K +K + +
Sbjct: 581 KSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAH 640
Query: 970 IKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDY 1029
+ + + + L+ K + R+FE+ C L L +LL+P+ R+ Y+ +L
Sbjct: 641 LWKHSEALEALENGIKSSRRLENFCRDFELQKVC-YLPLNTFLLRPLHRLMHYKQVLERL 699
Query: 1030 LKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRV 1089
K+ D+RD + ALA + E+ + TM + +NFQKL +++ L G +V PGR
Sbjct: 700 CKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGRE 759
Query: 1090 FLKEGILMKLSRKVMQPRMFFLFNDALLYTTP--VQSGMYKLNNMLSLAGMKVRKPTQE- 1146
F++ G L KLS K +Q RMFFLFND LLYT+ S +K++ L L GM + + E
Sbjct: 760 FIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEW 819
Query: 1147 AYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCP---------SRS 1197
+ L + +S I++ASS +E ++W+E I AI + A+K + P ++S
Sbjct: 820 GVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAI-DLAEKSSSPAPEFLASSPPDNKS 878
Query: 1198 LDE---ADSENKEEVSPLGSKAPIWIPDTRATMCMIC 1231
DE AD E+++++S + P TM +C
Sbjct: 879 PDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVC 915
Score = 57.4 bits (137), Expect = 1e-07
Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 1/97 (1%)
Query: 1333 DSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTV-IQVKDEN 1391
++ +SG L R N W+ W V N L+ Y + +D L S PLLG+++ I + EN
Sbjct: 932 ENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESEN 991
Query: 1392 SESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGT 1428
+ LH Y F+AE ++ ++W+E + T
Sbjct: 992 IQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSAT 1028
>gi|153791377 apoptosis-inducing protein D [Homo sapiens]
Length = 279
Score = 129 bits (323), Expect = 3e-29
Identities = 79/216 (36%), Positives = 112/216 (51%), Gaps = 24/216 (11%)
Query: 1086 PGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPV-QSGMYKLNNMLSLAGMKVRK-P 1143
PGRV L EG+L K RK +PR+FFLFND L+Y + V Y+ +++ L + + P
Sbjct: 32 PGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLNKRKYRSQHIIPLEEVTLELLP 91
Query: 1144 TQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADS 1203
+N I++ ++SF++SA+SATER EW+ I + + R T P
Sbjct: 92 ETLQAKNRWMIKTAKKSFVVSAASATERQEWISHIEECVRR--QLRATGRP--------- 140
Query: 1204 ENKEEVSPLGSKAPIWIPDTRATMCMICT-SEFTLTWRRHHCRACGKIVCQACSSNKYGL 1262
P A WIPD +CM CT + F+ RRHHCR CG +VC CS ++ L
Sbjct: 141 -------PSTEHAAPWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLL 193
Query: 1263 DYLKNQPARVCEHCFQEL---QKLDHQHSPRIGSPG 1295
L +P RVC C++EL Q+ + GSPG
Sbjct: 194 PRLSPKPVRVCSLCYRELAAQQRQEEAEEQGAGSPG 229
>gi|13375827 phafin 2 [Homo sapiens]
Length = 249
Score = 124 bits (311), Expect = 6e-28
Identities = 74/229 (32%), Positives = 115/229 (50%), Gaps = 25/229 (10%)
Query: 1086 PGRVFLKEGILMKLSRKVMQPRMFFLFNDALLY-TTPVQSGMYKLNNMLSLAGMKVRKPT 1144
PGRV + EG+L KL RK + R FFLFND L+Y +Q Y +++ L + +
Sbjct: 32 PGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIK 91
Query: 1145 QEA-YQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADS 1203
E +N I++ +SF + A++ATE+ EW+ I++ + D
Sbjct: 92 DEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCV------------------TDL 133
Query: 1204 ENKEEVSPLGSKAPIWIPDTRATMCMICT-SEFTLTWRRHHCRACGKIVCQACSSNKYGL 1262
+K +P A +W+PD+ AT+CM C ++FT RRHHCR CG +VC CS ++ L
Sbjct: 134 LSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLL 193
Query: 1263 DYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSI 1311
++P R+C+ C+ L D P S S +L S L+ +
Sbjct: 194 PSQSSKPVRICDFCYDLLSAGDMATC----QPARSDSYSQSLKSPLNDM 238
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 99.0 bits (245), Expect = 3e-20
Identities = 88/345 (25%), Positives = 157/345 (45%), Gaps = 23/345 (6%)
Query: 874 HIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQ-LGKPVIEDRILNQILYYLPQLYELN 932
H+A ++ +E+ +V+ L+ L + + L P + D I +QI P+L E +
Sbjct: 1069 HVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQI----PELLEHH 1124
Query: 933 RDLLKELEERMLHWTEQQRIADIFVK---KGPYLKMYSTYIKEFDKNIALLDEQCKKNPG 989
L+++ M W QQ++ + V+ K + +YS YI F + + P
Sbjct: 1125 EQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 1184
Query: 990 FAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAV 1049
F + + M AL ++KPVQRIP+Y LL+ D LK+ ED D+ +A
Sbjct: 1185 FLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRN 1243
Query: 1050 VIEVANHANDTMKQGDNFQK----LMQIQYSLNGHHEIVQPGRVFLKEGILMKLSR-KVM 1104
+ +VA N ++ + ++ L +I+ + G ++ P R FL++ +++++
Sbjct: 1244 IKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK 1303
Query: 1105 QPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILS 1164
+ R FLF D ++ TT + + +SL T Y+ K+ + I
Sbjct: 1304 KDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKG 1363
Query: 1165 ASSATERDEWLEAISRAIEEYA--------KKRITFCPSRSLDEA 1201
AS AT R+ +AISR E+ + + F P +SLD+A
Sbjct: 1364 ASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGF-PHQSLDDA 1407
>gi|21735572 epithelial cell transforming sequence 2 oncogene protein
[Homo sapiens]
Length = 883
Score = 98.6 bits (244), Expect = 4e-20
Identities = 65/262 (24%), Positives = 127/262 (48%), Gaps = 13/262 (4%)
Query: 822 QNDLGLG---DLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKE 878
++ L +G D+ + E IN D ++SSK P+ KQ S +AKE
Sbjct: 377 EHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSST-PVPSKQ-------SARWQVAKE 428
Query: 879 IMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKE 938
+ +E +V++L + I Q G P++ + I +P +++++ + +
Sbjct: 429 LYQTESNYVNILATI-IQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDD 487
Query: 939 LEERMLHWTEQQRIADIFVKKGPYL-KMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREF 997
LE+ +++W E + I DIF+K L K Y ++ F+ + + + K+ P F A ++
Sbjct: 488 LEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAFLKIN 547
Query: 998 EMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHA 1057
+ P C +L L++PVQR+P LLL D K+ ++ D + A+ + EV H
Sbjct: 548 QAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMTHI 607
Query: 1058 NDTMKQGDNFQKLMQIQYSLNG 1079
N+ ++ + +++ + Y ++G
Sbjct: 608 NEDKRKTEAQKQIFDVVYEVDG 629
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 92.4 bits (228), Expect = 3e-18
Identities = 89/344 (25%), Positives = 152/344 (44%), Gaps = 50/344 (14%)
Query: 878 EIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQ-----ILYYLPQLYELN 932
E++ +E+ +V+ L+L+ F+ KP++E +L + I +L N
Sbjct: 1244 ELIVTEENYVNDLQLVTEIFQ-----------KPLMESELLTEKEVAMIFVNWKELIMCN 1292
Query: 933 RDLLKELEERMLHWTEQ---QRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPG 989
LLK L R E+ + I DI + P+++ Y + AL+ ++ + P
Sbjct: 1293 IKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPD 1352
Query: 990 FAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAV 1049
F V+ M PRC + L ++LKP+QR+ +Y L++ + L+N E+ D+ + AL
Sbjct: 1353 FKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEK 1412
Query: 1050 VIEVANHANDTMKQGDNFQKLMQIQYSL-----------NGHHEIVQPGRVFLKEGILMK 1098
E+ + N+ +++ +N +L IQ + N + P R FL G L K
Sbjct: 1413 AEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGP-RKFLHSGKLYK 1471
Query: 1099 LSRKVMQPRMFFLFNDALLYT---------------TPVQSGMYKL-NNMLSLAGMKVRK 1142
K + FLFND LL T +P + YK+ + L + V+
Sbjct: 1472 --AKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKL 1529
Query: 1143 PTQEAYQNEL-KIESVERSFILSASSATERDEWLEAISRAIEEY 1185
PT + + I ++R + L A S ER W++ I A E Y
Sbjct: 1530 PTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELY 1573
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 90.5 bits (223), Expect = 1e-17
Identities = 105/483 (21%), Positives = 197/483 (40%), Gaps = 52/483 (10%)
Query: 660 GHLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYS---------LESQKKRKKSRGQ 710
G + GE KG Q E++ + P ++YS ++ S + S
Sbjct: 285 GGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEED 344
Query: 711 TSAANGLRAE-SLDDQMLSRESS---SQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFI 766
S+ R S + R+ S SQ +S S P + + + P + I
Sbjct: 345 FSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATI 404
Query: 767 MAIRKTQELEWQNSSSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLG 826
+ +RKT ++ + DA DG P + ++ A ++ ++ G
Sbjct: 405 VGVRKTGQIWPNDGEGAFHGDA------------DGSFGTPPGYGCAADRAEEQRRHQDG 452
Query: 827 L---GDLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSE 883
L D PS + +S + S + D + G++ + + I++SE
Sbjct: 453 LPYIDDSPSSSPHL-SSKGRGSRDALVSGALESTKASELDLEKGLEMR-KWVLSGILASE 510
Query: 884 KVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERM 943
+ ++ L+ L + + A A+ +PV+ + + I + +P+LYE++++ L R+
Sbjct: 511 ETYLSHLEALLLPMKPLKAAATTS--QPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRV 568
Query: 944 LHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFE----- 998
W+ QQR+ D+F K L +Y ++ + + + ++ C+ N FA +
Sbjct: 569 QQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNK 628
Query: 999 --MSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANH 1056
P N +L+ L KPV R+ + L+L D LK+ D+ QDAL + +
Sbjct: 629 DAKDPTTKN-SLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSS 687
Query: 1057 ANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDAL 1116
N+ + ++ M ++ G H R LK+ +++L + R FLF D L
Sbjct: 688 INEEITPR---RQSMTVK---KGEH------RQLLKDSFMVELVEGARKLRHVFLFTDLL 735
Query: 1117 LYT 1119
L T
Sbjct: 736 LCT 738
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 90.5 bits (223), Expect = 1e-17
Identities = 105/483 (21%), Positives = 197/483 (40%), Gaps = 52/483 (10%)
Query: 660 GHLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYS---------LESQKKRKKSRGQ 710
G + GE KG Q E++ + P ++YS ++ S + S
Sbjct: 285 GGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEED 344
Query: 711 TSAANGLRAE-SLDDQMLSRESS---SQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFI 766
S+ R S + R+ S SQ +S S P + + + P + I
Sbjct: 345 FSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATI 404
Query: 767 MAIRKTQELEWQNSSSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLG 826
+ +RKT ++ + DA DG P + ++ A ++ ++ G
Sbjct: 405 VGVRKTGQIWPNDGEGAFHGDA------------DGSFGTPPGYGCAADRAEEQRRHQDG 452
Query: 827 L---GDLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSE 883
L D PS + +S + S + D + G++ + + I++SE
Sbjct: 453 LPYIDDSPSSSPHL-SSKGRGSRDALVSGALESTKASELDLEKGLEMR-KWVLSGILASE 510
Query: 884 KVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERM 943
+ ++ L+ L + + A A+ +PV+ + + I + +P+LYE++++ L R+
Sbjct: 511 ETYLSHLEALLLPMKPLKAAATTS--QPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRV 568
Query: 944 LHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFE----- 998
W+ QQR+ D+F K L +Y ++ + + + ++ C+ N FA +
Sbjct: 569 QQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNK 628
Query: 999 --MSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANH 1056
P N +L+ L KPV R+ + L+L D LK+ D+ QDAL + +
Sbjct: 629 DAKDPTTKN-SLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSS 687
Query: 1057 ANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDAL 1116
N+ + ++ M ++ G H R LK+ +++L + R FLF D L
Sbjct: 688 INEEITPR---RQSMTVK---KGEH------RQLLKDSFMVELVEGARKLRHVFLFTDLL 735
Query: 1117 LYT 1119
L T
Sbjct: 736 LCT 738
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 88.6 bits (218), Expect = 4e-17
Identities = 86/367 (23%), Positives = 160/367 (43%), Gaps = 44/367 (11%)
Query: 855 PDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIE 914
P P ++ + ++ ++ + EI+ +E+ +V L+ L F + + +
Sbjct: 34 PGPCAAARESERQLRLRLC-VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLT 92
Query: 915 DRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQR--IADIFVKKGPYLKMYSTYIKE 972
+ + + + + E+++D L LE LH Q + + ++F+K +Y Y
Sbjct: 93 EENVKVLFSNIEDILEVHKDFLAALEY-CLHPEPQSQHELGNVFLKFKDKFCVYEEYCSN 151
Query: 973 FDKNIALLDEQCKKNPGFAAVVREFEMS------PRCANLALKHYLLKPVQRIPQYRLLL 1026
+K + LL E K VR F +S + ++ L+ YLL P+QRI +Y LLL
Sbjct: 152 HEKALRLLVELNK-----IPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLL 206
Query: 1027 TDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHH--EIV 1084
+ K D+ Q AL + V ++ N+T +Q + + L Q+Q + G +
Sbjct: 207 KELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLT 266
Query: 1085 QPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLY----------------TTPVQSGMYK 1128
L +G L+K+S +Q R FFLF++ L+Y T + +Y
Sbjct: 267 DICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYI 326
Query: 1129 LNNMLSLAGMKVRK---PTQEAYQNEL------KIESVERS--FILSASSATERDEWLEA 1177
++ M+V T + + N KI + ++ F+ A +A E+ +WL+A
Sbjct: 327 FRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDA 386
Query: 1178 ISRAIEE 1184
I R E+
Sbjct: 387 IIREREQ 393
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 87.4 bits (215), Expect = 9e-17
Identities = 78/272 (28%), Positives = 131/272 (48%), Gaps = 18/272 (6%)
Query: 851 SKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASR-QLG 909
S G P + D + V + +EI+ +E+ +V LK + D+ D + ++ LG
Sbjct: 95 SNGAPKTIADSATSPKLLY--VDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLG 152
Query: 910 KPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTY 969
E+R + + + +Y N +LL++LE + IA+ FV K +Y+ Y
Sbjct: 153 T---EER--SALFGNIQDIYHFNSELLQDLENCE---NDPVAIAECFVSKSEEFHIYTQY 204
Query: 970 IKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDY 1029
+ +++A+L E C +N A RE + + + +L L YLLKPVQRI +Y LLL +
Sbjct: 205 CTNYPRSVAVLTE-CMRNKILAKFFRERQETLK-HSLPLGSYLLKPVQRILKYHLLLHEI 262
Query: 1030 LKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHH--EIVQPG 1087
+L +D Y DA+ + VA H ND ++ ++ +L +IQ L ++ G
Sbjct: 263 ENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYG 322
Query: 1088 RVFLKEGILMKLSRKVMQPRMFFLFNDALLYT 1119
+ L EG ++ R FLF+ LL T
Sbjct: 323 ELVL-EGTFR--IQRAKNERTLFLFDKLLLIT 351
>gi|47717106 zinc finger, FYVE domain containing 9 isoform 3 [Homo
sapiens]
Length = 1425
Score = 85.5 bits (210), Expect = 3e-16
Identities = 43/105 (40%), Positives = 61/105 (58%), Gaps = 4/105 (3%)
Query: 1206 KEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYL 1265
++ + LG AP+W+PD++A CM C + FT T RRHHCRACGK+ C +C S K L Y+
Sbjct: 683 RKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYM 742
Query: 1266 KNQPARVCEHCFQEL---QKLDHQHSPRIGSPGNHKSPSSALSSV 1307
+ ARVC C L Q ++ S SP N +P+ S++
Sbjct: 743 DRKEARVCVICHSVLMNAQAWENMMSASSQSP-NPNNPAEYCSTI 786
>gi|157426866 zinc finger, FYVE domain containing 16 [Homo sapiens]
Length = 1539
Score = 85.5 bits (210), Expect = 3e-16
Identities = 54/154 (35%), Positives = 74/154 (48%), Gaps = 8/154 (5%)
Query: 1199 DEADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSN 1258
D +E LG K P W+PD+ A CM C +FT T RRHHCRACGK+ C C +
Sbjct: 724 DSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNR 783
Query: 1259 KYGLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSP--GNHKSPSSALSSVLHSIPSGRK 1316
K L YL+ + ARVC C++ + K Q R+ SP N KS S + + P +
Sbjct: 784 KCKLQYLEKE-ARVCVVCYETISKA--QAFERMMSPTGSNLKSNHSDECTTVQP-PQENQ 839
Query: 1317 QKKIPAALKEVSANTEDSSMSGYLYRSKGNKKPW 1350
IP+ + + + G SK K+ W
Sbjct: 840 TSSIPSPATLPVSALKQPGVEGLC--SKEQKRVW 871
>gi|157426864 zinc finger, FYVE domain containing 16 [Homo sapiens]
Length = 1539
Score = 85.5 bits (210), Expect = 3e-16
Identities = 54/154 (35%), Positives = 74/154 (48%), Gaps = 8/154 (5%)
Query: 1199 DEADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSN 1258
D +E LG K P W+PD+ A CM C +FT T RRHHCRACGK+ C C +
Sbjct: 724 DSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNR 783
Query: 1259 KYGLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSP--GNHKSPSSALSSVLHSIPSGRK 1316
K L YL+ + ARVC C++ + K Q R+ SP N KS S + + P +
Sbjct: 784 KCKLQYLEKE-ARVCVVCYETISKA--QAFERMMSPTGSNLKSNHSDECTTVQP-PQENQ 839
Query: 1317 QKKIPAALKEVSANTEDSSMSGYLYRSKGNKKPW 1350
IP+ + + + G SK K+ W
Sbjct: 840 TSSIPSPATLPVSALKQPGVEGLC--SKEQKRVW 871
>gi|47717112 zinc finger, FYVE domain containing 9 isoform 1 [Homo
sapiens]
Length = 1366
Score = 84.7 bits (208), Expect = 6e-16
Identities = 37/85 (43%), Positives = 50/85 (58%)
Query: 1206 KEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYL 1265
++ + LG AP+W+PD++A CM C + FT T RRHHCRACGK+ C +C S K L Y+
Sbjct: 683 RKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYM 742
Query: 1266 KNQPARVCEHCFQELQKLDHQHSPR 1290
+ ARVC C L + R
Sbjct: 743 DRKEARVCVICHSVLMNVAQPREQR 767
>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
Length = 1344
Score = 84.3 bits (207), Expect = 7e-16
Identities = 68/265 (25%), Positives = 118/265 (44%), Gaps = 29/265 (10%)
Query: 874 HIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNR 933
+I ++ SEK +VD LK + + ++ ++ V+ +R L + Y + ++ + +
Sbjct: 399 YILGSVVDSEKNYVDALKRILEQYEKPLS----EMEPKVLSERKLKTVFYRVKEILQCHS 454
Query: 934 DLLKELEERMLHWTEQQRIADIFV---KKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGF 990
L R+ W + I D+FV K L YS Y+ F +A+L + C P F
Sbjct: 455 LFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAF 514
Query: 991 AAVVR-EFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAV 1049
++ E E SP L ++KP+QR PQ+ LLL D LKN + D Q AL
Sbjct: 515 LEFLKQEQEASPD--RTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTE 572
Query: 1050 VIEVANHANDTMKQGDNFQKLMQIQYSLNGHH--EIVQPG------------RVFLKEGI 1095
+ +A N+ + D ++ QI ++N + +++ G V+ G
Sbjct: 573 LETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGE 632
Query: 1096 LMKLSRKVMQPRMFFLFNDALLYTT 1120
++K + R F+ ND L+ T
Sbjct: 633 IVK-----TKERRVFMLNDVLMCAT 652
>gi|6552337 zinc finger, FYVE domain containing 9 isoform 2 [Homo
sapiens]
Length = 762
Score = 84.0 bits (206), Expect = 1e-15
Identities = 36/75 (48%), Positives = 48/75 (64%)
Query: 1206 KEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYL 1265
++ + LG AP+W+PD++A CM C + FT T RRHHCRACGK+ C +C S K L Y+
Sbjct: 683 RKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYM 742
Query: 1266 KNQPARVCEHCFQEL 1280
+ ARVC C L
Sbjct: 743 DRKEARVCVICHSVL 757
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 82.4 bits (202), Expect = 3e-15
Identities = 96/390 (24%), Positives = 163/390 (41%), Gaps = 49/390 (12%)
Query: 828 GDLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFV 887
G PS+ ++ SD S+ + L+ Q + + +H E++ +E+ ++
Sbjct: 1147 GLFPSNYVKMTTDSDP----SQQWCADLQTLDTMQPIERKRQGYIH----ELIQTEERYM 1198
Query: 888 DVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWT 947
L+L+ F+ +A + + + + I +L N LLK L R
Sbjct: 1199 ADLQLVVEVFQKRMAESG------FLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGG 1252
Query: 948 EQ---QRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCA 1004
E+ Q I DI + +++ Y + ALL ++ ++ F +++ PRC
Sbjct: 1253 EKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCK 1312
Query: 1005 NLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQG 1064
+ L +LLKP+QRI +Y LL+ L+N E D+ + AL E+ + N+ +++
Sbjct: 1313 GMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREK 1372
Query: 1065 DNFQKLMQIQYSL-----------NGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFN 1113
+N +L IQ + N + P R L G L K K + FLFN
Sbjct: 1373 ENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGP-RKLLHSGKLYK--TKSNKELHGFLFN 1429
Query: 1114 DALLYT-----TPVQSGMYKLNNMLSLAGMK------------VRKPTQEAYQNEL-KIE 1155
D LL T V SG KL + S A K V+ PT + + I
Sbjct: 1430 DFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHIS 1489
Query: 1156 SVERSFILSASSATERDEWLEAISRAIEEY 1185
++R + L + ER W++ I A E+Y
Sbjct: 1490 HIDRVYTLRTDNINERTAWVQKIKAASEQY 1519
Score = 31.2 bits (69), Expect = 7.5
Identities = 13/35 (37%), Positives = 23/35 (65%)
Query: 925 LPQLYELNRDLLKELEERMLHWTEQQRIADIFVKK 959
L QLY++ RD LKE+E + L +++++ D +K
Sbjct: 634 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARK 668
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 82.4 bits (202), Expect = 3e-15
Identities = 96/390 (24%), Positives = 163/390 (41%), Gaps = 49/390 (12%)
Query: 828 GDLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFV 887
G PS+ ++ SD S+ + L+ Q + + +H E++ +E+ ++
Sbjct: 1174 GLFPSNYVKMTTDSDP----SQQWCADLQTLDTMQPIERKRQGYIH----ELIQTEERYM 1225
Query: 888 DVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWT 947
L+L+ F+ +A + + + + I +L N LLK L R
Sbjct: 1226 ADLQLVVEVFQKRMAESG------FLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGG 1279
Query: 948 EQ---QRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCA 1004
E+ Q I DI + +++ Y + ALL ++ ++ F +++ PRC
Sbjct: 1280 EKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCK 1339
Query: 1005 NLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQG 1064
+ L +LLKP+QRI +Y LL+ L+N E D+ + AL E+ + N+ +++
Sbjct: 1340 GMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREK 1399
Query: 1065 DNFQKLMQIQYSL-----------NGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFN 1113
+N +L IQ + N + P R L G L K K + FLFN
Sbjct: 1400 ENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGP-RKLLHSGKLYK--TKSNKELHGFLFN 1456
Query: 1114 DALLYT-----TPVQSGMYKLNNMLSLAGMK------------VRKPTQEAYQNEL-KIE 1155
D LL T V SG KL + S A K V+ PT + + I
Sbjct: 1457 DFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHIS 1516
Query: 1156 SVERSFILSASSATERDEWLEAISRAIEEY 1185
++R + L + ER W++ I A E+Y
Sbjct: 1517 HIDRVYTLRTDNINERTAWVQKIKAASEQY 1546
Score = 31.2 bits (69), Expect = 7.5
Identities = 13/35 (37%), Positives = 23/35 (65%)
Query: 925 LPQLYELNRDLLKELEERMLHWTEQQRIADIFVKK 959
L QLY++ RD LKE+E + L +++++ D +K
Sbjct: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARK 695
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 80.9 bits (198), Expect = 8e-15
Identities = 126/549 (22%), Positives = 221/549 (40%), Gaps = 88/549 (16%)
Query: 662 LSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAES 721
LSSG+ G L + K+S+ ++ + +S + +T G R E
Sbjct: 1784 LSSGKADGHVKK----LAHKHKKSREVRKSADAGSQKDSDDSAATPQDETVEERG-RNEG 1838
Query: 722 LDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNSS 781
L LS+ SSS C E EE + LP MAI++ L Q S
Sbjct: 1839 LSSGTLSKSSSSGM------QSCGEE-----EGEEGADAVPLPPPMAIQQHSLL--QPDS 1885
Query: 782 SMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINSS 841
+ A + + E P + + S + E++ L D N S
Sbjct: 1886 QDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPS 1945
Query: 842 DEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDF---- 897
D +SS S P+++ ++ + + H++ +E++ +E+ +V L + +
Sbjct: 1946 DNSLLSSSS------PIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALM 1999
Query: 898 -RDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDL-LKELEERMLHWTEQQRIADI 955
D V + K V + + Q+Y+ +RD L ELE+ + + +++ +
Sbjct: 2000 KEDGVPDDMKGKDKIVFGN---------IHQIYDWHRDFFLGELEKCL---EDPEKLGSL 2047
Query: 956 FVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREF------EMSPRCAN-LAL 1008
FVK L MY Y C+ P +V E+ ++ R + L L
Sbjct: 2048 FVKHERRLHMYIAY--------------CQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQL 2093
Query: 1009 KHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQ 1068
L+KPVQRI +Y+LLL D+LK + + D + + A+ V+ V ND M G
Sbjct: 2094 TDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVG---- 2149
Query: 1069 KLMQIQYSLNGHH-EIVQPGRVFLKEGILMKLSRKVMQP----RMFFLFNDALLYTTPVQ 1123
L G +IV G++ L++ L+ + P R FLF ++++ P+
Sbjct: 2150 -------RLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLD 2202
Query: 1124 SGM-YKLNNMLSLAGMKVR-KPTQEAYQNE-------LKIESVERSFILSASSATERDEW 1174
+ + L +KV +E +N+ + V +FIL +SS + R W
Sbjct: 2203 KKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTW 2262
Query: 1175 LEAISRAIE 1183
+ I++ +E
Sbjct: 2263 IHEINQILE 2271
Score = 65.9 bits (159), Expect = 3e-10
Identities = 86/362 (23%), Positives = 147/362 (40%), Gaps = 53/362 (14%)
Query: 845 DVSSESSKGEPDPLEDKQDEDNGMKSKV----HHIAKEIMSSEKVFVDVLKLLHIDFRDA 900
D+ S G L D E N K K I E++ +EK +V L+ +
Sbjct: 1262 DIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWE 1321
Query: 901 VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDL-LKELEERMLHWTEQQRIADIFVKK 959
+ ++ ++ ++ I + ++YE + ++ LKELE+ + + + FV
Sbjct: 1322 MTSGVEEIPPGIVNKELI--IFGNMQEIYEFHNNIFLKELEK---YEQLPEDVGHCFVTW 1376
Query: 960 GPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRI 1019
+MY TY K + L+ E + E + AN ++ YL+KPVQRI
Sbjct: 1377 ADKFQMYVTYCKNKPDSTQLILEHA------GSYFDEIQQRHGLAN-SISSYLIKPVQRI 1429
Query: 1020 PQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNG 1079
+Y+LLL + L E G+ + D L V++ V AND M L G
Sbjct: 1430 TKYQLLLKELLTCCEEGKGEIK---DGLEVMLSVPKRANDAMHLS-----------MLEG 1475
Query: 1080 HHE-IVQPGRVFLKEGILM---KLSRKVMQPRMFFLFNDALLYTTPVQSG------MYKL 1129
E I G + L+E + K + + R FLF +L+++ V+ +YK
Sbjct: 1476 FDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKS 1535
Query: 1130 NNMLSLAGMKVRKPTQEAYQNELKI-------ESVERSFILSASSATERDEWLEAISRAI 1182
S G+ T+ + K + + +L ASS + +W++ I I
Sbjct: 1536 KLFTSELGV-----TEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVI 1590
Query: 1183 EE 1184
+E
Sbjct: 1591 QE 1592
>gi|38679954 active breakpoint cluster region-related protein isoform
b [Homo sapiens]
Length = 822
Score = 79.7 bits (195), Expect = 2e-14
Identities = 83/393 (21%), Positives = 174/393 (44%), Gaps = 44/393 (11%)
Query: 819 QEEQNDLGLGDLPSDEEEIINSSDEDDVSSESSKGEPDP--LEDKQDEDNGMKSKVHHIA 876
+EE+ +GL D ++E++ +E ++ + +S G P + K + G++ + +
Sbjct: 2 EEEEEAIGLLDKVLEDEDVF-LLEECELGTPTSPGSGSPFLVAVKVEAGKGLEMR-KLVL 59
Query: 877 KEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLL 936
++SE+++++ L+ L + + A A+ +PV+ + + I Y + +YE++++
Sbjct: 60 SGFLASEEIYINQLEALLLPMKPLKATATTS--QPVLTIQQIETIFYKIQDIYEIHKEFY 117
Query: 937 KELEERMLHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVRE 996
L ++ W Q + +F K L +Y ++ + + ++ + N F + E
Sbjct: 118 DNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEE 177
Query: 997 FEM-SPRCA-----NLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVV 1050
++ P+ + ++ ++ L KP+ R+ + L+L D LK+ D DY QDAL +
Sbjct: 178 LKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRI- 236
Query: 1051 IEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQ----PGRVFLKEGILMKLSRKVMQP 1106
NF L I ++ V R +K+G L+++S +
Sbjct: 237 -------------SQNF--LSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKL 281
Query: 1107 RMFFLFNDALL-----YTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNEL------KIE 1155
R FLF D LL T+ + Y + LA + P + ++ ++E
Sbjct: 282 RHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELE 341
Query: 1156 SVERSFILSASSATERDEWLEAISRAIEEYAKK 1188
++ I + S ++++ + SRAIE KK
Sbjct: 342 DMKMK-ISALKSEIQKEKANKGQSRAIERLKKK 373
>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 2 [Homo sapiens]
Length = 1240
Score = 78.6 bits (192), Expect = 4e-14
Identities = 80/338 (23%), Positives = 146/338 (43%), Gaps = 26/338 (7%)
Query: 760 YENLPFIMAIRKTQELEWQNSS-------SMEDADANVYEVEEPYEAPDGQLQLGPRHQH 812
YE+ A R+ ++L W +S S E+A V EVE Q ++ +
Sbjct: 152 YEDAHRAGAPRQAEDLGWSSSEFESYSEDSGEEAKPEV-EVEPAKHRVSFQPKMTQLMKA 210
Query: 813 SSSGASQE-EQNDLGLGDLPS--DEEEIINSSDEDDVS----SESSKGEPDPLEDKQDED 865
+ SG E+ + + S ++++ S+E+D+ S S P P E
Sbjct: 211 AKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEG 270
Query: 866 NGMKSKVH-HIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYY 924
+ V HI I+ SE +V+ LK + D+R+ + ++ + R + +
Sbjct: 271 LSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLM----EMEPKALSARKCQVVFFR 326
Query: 925 LPQLYELNRDLLKELEERMLHWTEQQRIADIFV---KKGPYLKMYSTYIKEFDKNIALLD 981
+ ++ + L R+ W ++I D+FV K L +YS Y+ F ++++
Sbjct: 327 VKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIK 386
Query: 982 EQCKKNPGFAAVVREFEM-SPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDY 1040
+ C P F ++ ++ SP + L ++KP+QR PQ+ LLL D LKN D
Sbjct: 387 KACLTKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDR 444
Query: 1041 RDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLN 1078
Q AL + +A N+ + D ++ Q+ S++
Sbjct: 445 LSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVS 482
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 78.6 bits (192), Expect = 4e-14
Identities = 146/660 (22%), Positives = 264/660 (40%), Gaps = 84/660 (12%)
Query: 666 EQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAESLDDQ 725
+ + +ES Q L EE++ + + T + + Q + +R QT+ L+ ++ +
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE-LQKVKMEKE 849
Query: 726 MLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKT-QELEWQNSSSME 784
L E S+ K S + +N + E + I+ + KT +EL+ Q ME
Sbjct: 850 ALMTELST---VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQME 906
Query: 785 DADANVYEVEEPYEAPDG-----QLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIIN 839
+ E+++ E +L+L + + +QN+ L + E+
Sbjct: 907 NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
Query: 840 SSDEDDVSSESSKGEPD-PLEDKQDEDNGMKSKVHHIAKEIMSS-EKVFV---------D 888
SS++ E+ +GE + K + +N ++ ++ A+E+ + EK+ V +
Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
Query: 889 VLKLLHIDF--RDAVAHASRQLGKPVIEDRILNQ--ILYYLPQLYELNRDLLKELEERML 944
K L DF R++ A+RQ K V E L Q ++ Q+ N+ L++EL+
Sbjct: 1027 TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK-LIQELK---- 1081
Query: 945 HWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREF----EMS 1000
T + + KK L+ +++ K +L +++ A + E E
Sbjct: 1082 --TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
Query: 1001 PRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANH---- 1056
N LK + L+ ++ I L D + LI+ + + D+L +E
Sbjct: 1140 ITKLNEELKSHKLESIKEITN----LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195
Query: 1057 ANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDAL 1116
D +K+ + K I+ H EI + + + MK + N+A
Sbjct: 1196 LKDQVKKEEEELKKEFIEKEAKLHSEIKE-------KEVGMKKHEE----------NEAK 1238
Query: 1117 LYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSF-ILSASSATERDEWL 1175
L T + + LN L + + + + E + + + +L A+ +DE
Sbjct: 1239 L-TMQITA----LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293
Query: 1176 EAISRA------IEEYAKKRITFCPSRSLD-------EADSENKE-EVSPLGSKAPIWIP 1221
+ R IE+ K + R LD E EN+ ++ + W
Sbjct: 1294 ALLERCLKGEGEIEKLQTKVLEL--QRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAE 1351
Query: 1222 DTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCFQELQ 1281
D CM C F++T RRHHCR CG I C CS+ K L +P RVC+ CF +LQ
Sbjct: 1352 DNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSA-KNALTPSSKKPVRVCDACFNDLQ 1410
Score = 31.6 bits (70), Expect = 5.7
Identities = 76/392 (19%), Positives = 158/392 (40%), Gaps = 50/392 (12%)
Query: 372 QEQVDKM--KLGNKSELNMESNSDAQDLVNSQKAMC----NETTSFEKMAPSFDKDSNLS 425
QEQV ++ KL N+SE + ++ + D V QKA + S E + N S
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 426 SDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQMQKESV 485
+ S + + + T + + ++ L HL + +N + Q + +
Sbjct: 634 KEKV----SQLDIQIKAKTELLLSAEAAKTAQRADL--QNHLDTAQN-ALQDKQQELNKI 686
Query: 486 IKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSE-----KSLERNH 540
+ + + + Q H LK+ K Y S E+K+ E K LE +
Sbjct: 687 TTQLDQVTAKLQDKQEHCSQLESHLKE-------YKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 541 LQHLCAQNRGVSS-------SFDMPKRASE-KPVWKLPHPILPFSGNPEFLKSVTVSSNS 592
L+ ++ + + + D+ RA+E ++ I+ + KS + S
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 593 EPSTALTKPRAKSLSAMDVEKCTKPCK------DSTKKNSFKKLLSMKLSICFMKSDFQK 646
+ T + K + D E ++ K ++ + + +L +K+ + ++
Sbjct: 800 QKLT--KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857
Query: 647 FWSKSSQLGDTTTGHLSSGEQKGIESDWQGLLVGEEKRSKPIK---AYSTENYSLESQKK 703
K S++ D+ S E++ + + ++ EK K +K EN +L+ QK+
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKG--KAAILDLEKTCKELKHQLQVQMEN-TLKEQKE 914
Query: 704 RKKS-RGQTSAANGLRAE--SLDDQMLSRESS 732
KKS + A++ L+ E S+ +Q++ +++
Sbjct: 915 LKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,972,762
Number of Sequences: 37866
Number of extensions: 2805793
Number of successful extensions: 12075
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 152
Number of HSP's successfully gapped in prelim test: 304
Number of HSP's that attempted gapping in prelim test: 10807
Number of HSP's gapped (non-prelim): 1461
length of query: 1430
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1315
effective length of database: 13,892,928
effective search space: 18269200320
effective search space used: 18269200320
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.