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Search of human proteins with 13259546
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
(275 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 555 e-158
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 555 e-158
gi|13259541 uncoupling protein 2 [Homo sapiens] 387 e-108
gi|11225256 uncoupling protein 1 [Homo sapiens] 310 9e-85
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 159 3e-39
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 158 4e-39
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 158 4e-39
gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 155 5e-38
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 145 3e-35
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 140 9e-34
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 106 3e-23
gi|41462412 solute carrier family 25, member 35 [Homo sapiens] 93 2e-19
gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 91 1e-18
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 90 2e-18
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 89 5e-18
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 87 1e-17
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 87 1e-17
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 87 1e-17
gi|13899342 solute carrier [Homo sapiens] 87 2e-17
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade... 84 1e-16
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 84 1e-16
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 84 2e-16
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 84 2e-16
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 84 2e-16
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 82 5e-16
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 82 5e-16
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 82 5e-16
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 80 2e-15
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 79 4e-15
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 74 1e-13
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 555 bits (1430), Expect = e-158
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 60
MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG
Sbjct: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 60
Query: 61 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 120
VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI
Sbjct: 61 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 120
Query: 121 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 180
LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK
Sbjct: 121 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 180
Query: 181 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 240
GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV
Sbjct: 181 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 240
Query: 241 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG
Sbjct: 241 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 555 bits (1430), Expect = e-158
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 60
MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG
Sbjct: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 60
Query: 61 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 120
VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI
Sbjct: 61 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 120
Query: 121 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 180
LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK
Sbjct: 121 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 180
Query: 181 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 240
GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV
Sbjct: 181 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 240
Query: 241 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG
Sbjct: 241 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
Score = 60.1 bits (144), Expect = 2e-09
Identities = 47/205 (22%), Positives = 77/205 (37%), Gaps = 9/205 (4%)
Query: 12 TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRT 71
++ + L T A P D KVR Q ++ R +Y G + T+ R
Sbjct: 115 SLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDR--KYSGTMDAYRTIARE 172
Query: 72 EGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAV 131
EG + G + + R + YD +K+ + ++ G A
Sbjct: 173 EGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCAT 232
Query: 132 TCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAI 191
A P DVVK R+ S +Y +D + +EG +KG P+ +R
Sbjct: 233 VVASPVDVVKTRYMNS-------PPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGS 285
Query: 192 VNCAEVVTYDILKEKLLDYHLLTDN 216
N VTY+ LK L+ +L ++
Sbjct: 286 WNVVMFVTYEQLKRALMKVQMLRES 310
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 387 bits (993), Expect = e-108
Identities = 196/276 (71%), Positives = 226/276 (81%), Gaps = 5/276 (1%)
Query: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQA-VQTARLVQYR 59
MVG K +DVPPT VKFLGAGTAAC ADL+TFPLDTAKVRLQIQGE+Q V+ QYR
Sbjct: 1 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60
Query: 60 GVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTR 119
GV+GTILTMVRTEGP S YNGLVAGLQRQMSFAS+RIGLYDSVKQ YT KG++++S+ +R
Sbjct: 61 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYT-KGSEHASIGSR 119
Query: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179
+LAG TTGA+AV AQPTDVVKVRFQA G R+Y T++AY+TIAREEG RGLW
Sbjct: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLW 176
Query: 180 KGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVD 239
KGT PN+ RNAIVNCAE+VTYD++K+ LL +L+TD+ PCHF SAFGAGFC TV+ASPVD
Sbjct: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVD 236
Query: 240 VVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
VVKTRYMNS GQY S C + M+ +EGP AFYKG
Sbjct: 237 VVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKG 272
Score = 62.0 bits (149), Expect = 5e-10
Identities = 50/193 (25%), Positives = 72/193 (37%), Gaps = 12/193 (6%)
Query: 16 KFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPC 75
+ L T A V P D KVR Q Q + +Y+ + T+ R EG
Sbjct: 119 RLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR-----RYQSTVNAYKTIAREEGFR 173
Query: 76 SPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQ 135
+ G + R + YD +K L + G A
Sbjct: 174 GLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIAS 233
Query: 136 PTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195
P DVVK R+ S LG +YS T+ ++EG R +KG +P+ +R N
Sbjct: 234 PVDVVKTRYMNSA-LG------QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVV 286
Query: 196 EVVTYDILKEKLL 208
VTY+ LK L+
Sbjct: 287 MFVTYEQLKRALM 299
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 310 bits (794), Expect = 9e-85
Identities = 157/275 (57%), Positives = 202/275 (73%), Gaps = 5/275 (1%)
Query: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG 60
M GL SDV PT+ V+ AG AAC AD++TFPLDTAKVRLQ+QGE T+ +++Y+G
Sbjct: 1 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGE---CPTSSVIRYKG 57
Query: 61 VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI 120
VLGTI +V+TEG Y+GL AGLQRQ+S AS+RIGLYD+V++ T SL ++I
Sbjct: 58 VLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKI 117
Query: 121 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 180
LAG TTG +AV QPT+VVKVR QA HL + +Y+GT +AYR IA EG+ GLWK
Sbjct: 118 LAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP--RYTGTYNAYRIIATTEGLTGLWK 175
Query: 181 GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV 240
GT PN+MR+ I+NC E+VTYD++KE + ++L D+ PCH VSA AGFCAT ++SPVDV
Sbjct: 176 GTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDV 235
Query: 241 VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
VKTR++NSPPGQY S +C +K+ EGPTAF+KG
Sbjct: 236 VKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKG 270
Score = 61.2 bits (147), Expect = 9e-10
Identities = 46/200 (23%), Positives = 77/200 (38%), Gaps = 11/200 (5%)
Query: 8 DVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILT 67
+ P++ K L T A + P + KVRLQ Q ++ +Y G
Sbjct: 108 ETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKP----RYTGTYNAYRI 163
Query: 68 MVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTG 127
+ TEG + G L R + + YD +K+ + + +++ G
Sbjct: 164 IATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAG 223
Query: 128 AMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIM 187
A + P DVVK RF I+ P + Y + + EG +KG +P+ +
Sbjct: 224 FCATAMSSPVDVVKTRF---INSPPGQ----YKSVPNCAMKVFTNEGPTAFFKGLVPSFL 276
Query: 188 RNAIVNCAEVVTYDILKEKL 207
R N V ++ LK +L
Sbjct: 277 RLGSWNVIMFVCFEQLKREL 296
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 159 bits (401), Expect = 3e-39
Identities = 94/265 (35%), Positives = 145/265 (54%), Gaps = 15/265 (5%)
Query: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
F+ G A+ A+ TFP+D K RLQIQG+ + ++YRG+L ++ + R EG +
Sbjct: 9 FVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKE-IRYRGMLHALVRIGREEGLKA 67
Query: 77 PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136
Y+G+ + RQ S+ +I+IG Y S+K+++ + D + L ++ G +G ++ T A P
Sbjct: 68 LYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDET-LPINVICGILSGVISSTIANP 126
Query: 137 TDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAE 196
TDV+K+R QA +S+ G + + I ++EG RGLWKG R AIV E
Sbjct: 127 TDVLKIRMQA-------QSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVE 179
Query: 197 VVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPP------ 250
+ YDI K+ L+ L+ D HF+S+F G + ++PVDVV+TR MN
Sbjct: 180 LPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRC 239
Query: 251 GQYFSPLDCMIKMVAQEGPTAFYKG 275
Y LDC+++ EG A YKG
Sbjct: 240 SGYTGTLDCLLQTWKNEGFFALYKG 264
Score = 65.9 bits (159), Expect = 4e-11
Identities = 50/201 (24%), Positives = 84/201 (41%), Gaps = 12/201 (5%)
Query: 5 KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64
+P D T+ + + + + + P D K+R+Q Q + +Q G++G
Sbjct: 100 RPED--ETLPINVICGILSGVISSTIANPTDVLKIRMQAQ--SNTIQG-------GMIGN 148
Query: 65 ILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC 124
+ + + EG + G+ QR + + +YD K+ G ++ T L+
Sbjct: 149 FMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSF 208
Query: 125 TTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184
T G + P DVV+ R L R Y+GT+D + EG L+KG P
Sbjct: 209 TCGLAGALASNPVDVVRTRMMNQRVLRDGRCSG-YTGTLDCLLQTWKNEGFFALYKGFWP 267
Query: 185 NIMRNAIVNCAEVVTYDILKE 205
N +R N VTY+ LK+
Sbjct: 268 NWLRLGPWNIIFFVTYEQLKK 288
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 158 bits (400), Expect = 4e-39
Identities = 92/265 (34%), Positives = 149/265 (56%), Gaps = 16/265 (6%)
Query: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
F+ G A+ A+ TFP+D K RLQ+QG++ + ++YRG+ + + + EG +
Sbjct: 44 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKE-IKYRGMFHALFRICKEEGVLA 102
Query: 77 PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136
Y+G+ L RQ S+ +I+IG+Y S+K+++ + ++ +L ++ G +G ++ T A P
Sbjct: 103 LYSGIAPALLRQASYGTIKIGIYQSLKRLFVER-LEDETLLINMICGVVSGVISSTIANP 161
Query: 137 TDVVKVRFQASIHLGPSRSDRKYSGTM-DAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195
TDV+K+R QA L + G+M ++ I ++EG RGLW+G +P R AIV
Sbjct: 162 TDVLKIRMQAQGSL--------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGV 213
Query: 196 EVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPP----- 250
E+ YDI K+ L+ ++ D HFVS+F G + ++PVDVV+TR MN
Sbjct: 214 ELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHV 273
Query: 251 GQYFSPLDCMIKMVAQEGPTAFYKG 275
Y +D ++KM EG A YKG
Sbjct: 274 DLYKGTVDGILKMWKHEGFFALYKG 298
Score = 63.2 bits (152), Expect = 2e-10
Identities = 48/198 (24%), Positives = 85/198 (42%), Gaps = 21/198 (10%)
Query: 12 TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG-VLGTILTMVR 70
T+ + + + + + P D K+R+Q QG ++G ++G+ + + +
Sbjct: 140 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGS----------LFQGSMIGSFIDIYQ 189
Query: 71 TEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMA 130
EG + G+V QR + + +YD K+ G ++ T ++ T G
Sbjct: 190 QEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAG 249
Query: 131 VTCAQPTDVVKVRF--QASI--HLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186
+ P DVV+ R Q +I H+ Y GT+D + + EG L+KG PN
Sbjct: 250 ALASNPVDVVRTRMMNQRAIVGHVD------LYKGTVDGILKMWKHEGFFALYKGFWPNW 303
Query: 187 MRNAIVNCAEVVTYDILK 204
+R N +TY+ LK
Sbjct: 304 LRLGPWNIIFFITYEQLK 321
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 158 bits (400), Expect = 4e-39
Identities = 92/265 (34%), Positives = 149/265 (56%), Gaps = 16/265 (6%)
Query: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
F+ G A+ A+ TFP+D K RLQ+QG++ + ++YRG+ + + + EG +
Sbjct: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKE-IKYRGMFHALFRICKEEGVLA 99
Query: 77 PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136
Y+G+ L RQ S+ +I+IG+Y S+K+++ + ++ +L ++ G +G ++ T A P
Sbjct: 100 LYSGIAPALLRQASYGTIKIGIYQSLKRLFVER-LEDETLLINMICGVVSGVISSTIANP 158
Query: 137 TDVVKVRFQASIHLGPSRSDRKYSGTM-DAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195
TDV+K+R QA L + G+M ++ I ++EG RGLW+G +P R AIV
Sbjct: 159 TDVLKIRMQAQGSL--------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGV 210
Query: 196 EVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPP----- 250
E+ YDI K+ L+ ++ D HFVS+F G + ++PVDVV+TR MN
Sbjct: 211 ELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHV 270
Query: 251 GQYFSPLDCMIKMVAQEGPTAFYKG 275
Y +D ++KM EG A YKG
Sbjct: 271 DLYKGTVDGILKMWKHEGFFALYKG 295
Score = 63.2 bits (152), Expect = 2e-10
Identities = 48/198 (24%), Positives = 85/198 (42%), Gaps = 21/198 (10%)
Query: 12 TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG-VLGTILTMVR 70
T+ + + + + + P D K+R+Q QG ++G ++G+ + + +
Sbjct: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGS----------LFQGSMIGSFIDIYQ 186
Query: 71 TEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMA 130
EG + G+V QR + + +YD K+ G ++ T ++ T G
Sbjct: 187 QEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAG 246
Query: 131 VTCAQPTDVVKVRF--QASI--HLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186
+ P DVV+ R Q +I H+ Y GT+D + + EG L+KG PN
Sbjct: 247 ALASNPVDVVRTRMMNQRAIVGHVD------LYKGTVDGILKMWKHEGFFALYKGFWPNW 300
Query: 187 MRNAIVNCAEVVTYDILK 204
+R N +TY+ LK
Sbjct: 301 LRLGPWNIIFFITYEQLK 318
>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
Length = 323
Score = 155 bits (391), Expect = 5e-38
Identities = 94/273 (34%), Positives = 141/273 (51%), Gaps = 11/273 (4%)
Query: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTA----RLVQYRGVLGTILTMV 69
A KFL +G AA A+L TFPLD K RLQ+QGE + YRG++ T L ++
Sbjct: 20 ASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGII 79
Query: 70 RTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNS-SLTTRILAGCTTGA 128
EG + G+ + R + ++ R+ Y+ +++V K D L ++ G G
Sbjct: 80 EEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGV 139
Query: 129 MAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMR 188
+ A PTD+VKV+ Q ++ G A+ I E G+RGLW G +PNI R
Sbjct: 140 IGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQR 199
Query: 189 NAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNS 248
A+VN ++ TYD +K L+ L DN H +S+ +G A+++ +P DV+K+R MN
Sbjct: 200 AALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQ 259
Query: 249 PPGQ------YFSPLDCMIKMVAQEGPTAFYKG 275
P + Y S DC+I+ V EG + YKG
Sbjct: 260 PRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKG 292
Score = 51.2 bits (121), Expect = 1e-06
Identities = 43/188 (22%), Positives = 77/188 (40%), Gaps = 3/188 (1%)
Query: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
+G A + P D KV++Q++G+ + + +++RGV ++ G
Sbjct: 132 IGGMMAGVIGQFLANPTDLVKVQMQMEGKRKL--EGKPLRFRGVHHAFAKILAEGGIRGL 189
Query: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPT 137
+ G V +QR + YD+VK ++ T L+ +G +A P
Sbjct: 190 WAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPA 249
Query: 138 DVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEV 197
DV+K R R Y + D + EG L+KG LP+ +R +
Sbjct: 250 DVIKSRIMNQPRDKQGRG-LLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFW 308
Query: 198 VTYDILKE 205
+TY+ ++E
Sbjct: 309 LTYEKIRE 316
>gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
Length = 287
Score = 145 bits (367), Expect = 3e-35
Identities = 93/255 (36%), Positives = 131/255 (51%), Gaps = 13/255 (5%)
Query: 21 GTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNG 80
G A+C A T PLD KV LQ Q E + T G L +VRT+G + Y+G
Sbjct: 14 GLASCGAACCTHPLDLLKVHLQTQQEVKLRMT----------GMALRVVRTDGILALYSG 63
Query: 81 LVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVV 140
L A L RQM+++ R +Y++V+ ++L G +G P D+V
Sbjct: 64 LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123
Query: 141 KVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTY 200
VR Q + L P R Y+ +D +AREEG+R L+ G R A+V ++ Y
Sbjct: 124 NVRMQNDVKL-PQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182
Query: 201 DILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCM 260
D K+ +L L+DN HFV++F AG CAT + P+DV+KTR MNS G+Y C
Sbjct: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS-KGEYQGVFHCA 241
Query: 261 IKMVAQEGPTAFYKG 275
++ A+ GP AFYKG
Sbjct: 242 VE-TAKLGPLAFYKG 255
>gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
Length = 314
Score = 140 bits (354), Expect = 9e-34
Identities = 89/275 (32%), Positives = 134/275 (48%), Gaps = 12/275 (4%)
Query: 5 KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64
KP P + VKFL G A A + PLD K R+Q+ GE A+ +Y+
Sbjct: 15 KPRTSPKS--VKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEG-----AKTREYKTSFHA 67
Query: 65 ILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC 124
+ ++++ EG Y GL AGL RQ ++ + R+G+Y + + T + + G
Sbjct: 68 LTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGM 127
Query: 125 TTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184
T GA P +V +R A L P+ R Y +A I REEGV LW+G +P
Sbjct: 128 TAGATGAFVGTPAEVALIRMTADGRL-PADQRRGYKNVFNALIRITREEGVLTLWRGCIP 186
Query: 185 NIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTR 244
+ R +VN A++ +Y K+ LLD +DN CHF ++ +G T + PVD+ KTR
Sbjct: 187 TMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTR 246
Query: 245 YMN----SPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
N +Y + LD + K+V EG + +KG
Sbjct: 247 IQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKG 281
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 106 bits (264), Expect = 3e-23
Identities = 83/278 (29%), Positives = 127/278 (45%), Gaps = 22/278 (7%)
Query: 9 VPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTM 68
VPP AV + +A C A + T PL+ K RLQ+QGE QA T Y G + ++ +
Sbjct: 4 VPP--AVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPR-PYHGFIASVAAV 60
Query: 69 VRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGA 128
R +G GL AGL Q +R Y Q + + ++AG GA
Sbjct: 61 ARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT-----VVAGAVAGA 115
Query: 129 MAVTCAQPTDVVKVRFQ----ASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184
+ P ++K + Q A++ +G + + G ++ TI R++G+ GLW+G
Sbjct: 116 LGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALE---TIWRQQGLLGLWQGVGG 172
Query: 185 NIMRNAIVNCAEVVTYDILKEKLLDYHLL-TDNFPCHFVSAFGAGFCATVVASPVDVVKT 243
+ R + + A++ T+ K + L D++ + VV +P DVV T
Sbjct: 173 AVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVST 232
Query: 244 RYMNSP-----PGQYFSPL-DCMIKMVAQEGPTAFYKG 275
R N P GQ + L DCM+K+ QEGP A YKG
Sbjct: 233 RLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKG 270
Score = 41.2 bits (95), Expect = 0.001
Identities = 43/189 (22%), Positives = 72/189 (38%), Gaps = 3/189 (1%)
Query: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
+ A V P K +LQ Q AV ++ VLG + T+ R +G
Sbjct: 108 VAGAVAGALGAFVGSPAYLIKTQLQAQTV-AAVAVGHQHNHQTVLGALETIWRQQGLLGL 166
Query: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQ-VYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136
+ G+ + R M ++ ++ + S K V + S + G + V P
Sbjct: 167 WQGVGGAVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTP 226
Query: 137 TDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAE 196
DVV R + + + Y G D I R+EG L+KG P +R
Sbjct: 227 FDVVSTRLYNQ-PVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILS 285
Query: 197 VVTYDILKE 205
++ +D L++
Sbjct: 286 MLFWDELRK 294
>gi|41462412 solute carrier family 25, member 35 [Homo sapiens]
Length = 295
Score = 93.2 bits (230), Expect = 2e-19
Identities = 69/241 (28%), Positives = 111/241 (46%), Gaps = 14/241 (5%)
Query: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
FL +G AAC A + T PL+ K R+Q+QGE QA T + YR V +T+ + +G +
Sbjct: 3 FLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQR-HYRNVFHAFITIGKVDGLAA 61
Query: 77 PYNGLVAGLQRQMSFASIRIGLY---DSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTC 133
GL L Q IR+G Y ++ ++T +G + + + AG G M
Sbjct: 62 LQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARSA--AAGAMAGVMGAYL 119
Query: 134 AQPTDVVKVRFQA----SIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRN 189
P +VK QA I +G K+ G A I ++ G+ GLW+G L + R
Sbjct: 120 GSPIYMVKTHLQAQAASEIAVG---HQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRV 176
Query: 190 AIVNCAEVVTYDILKEKLLDYHLL-TDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNS 248
+ + ++ T+ K+ L + + ++ V+A +G + +P DV TR N
Sbjct: 177 IVGSSTQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYNQ 236
Query: 249 P 249
P
Sbjct: 237 P 237
>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
Length = 298
Score = 90.5 bits (223), Expect = 1e-18
Identities = 73/277 (26%), Positives = 121/277 (43%), Gaps = 23/277 (8%)
Query: 12 TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRT 71
+ A FL G AA + P++ K+ LQ+Q ++ + + QY+G++ I+ + +
Sbjct: 7 SFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK--QYKGIVDCIVRIPKE 64
Query: 72 EGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC-----TT 126
+G S + G +A + R ++ D KQ++ G D + R AG
Sbjct: 65 QGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG-GVDKHTQFWRYFAGNLASGGAA 123
Query: 127 GAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186
GA ++ P D + R A + G S ++R++ G D I + +G+RGL++G ++
Sbjct: 124 GATSLCFVYPLDFARTRLAADV--GKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSV 181
Query: 187 MRNAIVNCAEVVTYDILKEKLLD---YHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKT 243
I A YD K L D H++ V+A A VV+ P D V+
Sbjct: 182 QGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTA-----VAGVVSYPFDTVRR 236
Query: 244 RYM-----NSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
R M Y +DC K+ EG AF+KG
Sbjct: 237 RMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKG 273
Score = 64.3 bits (155), Expect = 1e-10
Identities = 49/185 (26%), Positives = 88/185 (47%), Gaps = 15/185 (8%)
Query: 22 TAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGL 81
T+ CF +PLD A+ RL + ++RG+ ++ + +++G Y G
Sbjct: 126 TSLCFV----YPLDFARTRLAADVGKSGTER----EFRGLGDCLVKITKSDGIRGLYQGF 177
Query: 82 VAGLQRQMSFASIRIGLYDSVKQVYT-PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVV 140
+Q + + + G+YD+ K + PK N+ + + T A+A + P D V
Sbjct: 178 SVSVQGIIIYRAAYFGVYDTAKGMLPDPK---NTHIVVSWMIAQTVTAVAGVVSYPFDTV 234
Query: 141 KVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTY 200
+ R + G +D Y+GT+D +R I R+EG + +KG N++R + +V Y
Sbjct: 235 RRRMM--MQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLY 291
Query: 201 DILKE 205
D LK+
Sbjct: 292 DELKK 296
Score = 38.5 bits (88), Expect = 0.006
Identities = 26/103 (25%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 3 GLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVL 62
G+ P + V ++ A T A +V++P DT + R+ +Q + + Y G +
Sbjct: 200 GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGAD----IMYTGTV 255
Query: 63 GTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQV 105
+ R EG + + G + + R M A + + LYD +K+V
Sbjct: 256 DCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLV-LYDELKKV 297
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 89.7 bits (221), Expect = 2e-18
Identities = 77/274 (28%), Positives = 114/274 (41%), Gaps = 40/274 (14%)
Query: 30 VTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGL-----VAG 84
V +PLDT KVR+Q + + Y G+ + E Y GL
Sbjct: 16 VGYPLDTVKVRIQTEPK-----------YTGIWHCVRDTYHRERVWGFYRGLSLPVCTVS 64
Query: 85 LQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRF 144
L +SF + R L + Y A + L+GC +G + V PT+V KVR
Sbjct: 65 LVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADIT-LSGCASGLVRVFLTSPTEVAKVRL 123
Query: 145 QASIH---------------------LGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTL 183
Q + P+ + KY G + T+AREEG+ GL+KG+
Sbjct: 124 QTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSS 183
Query: 184 PNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKT 243
++R+ ++Y +L E L + P V+ AG A VA+P+DV+K+
Sbjct: 184 ALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKS 243
Query: 244 RYMNSPPGQ--YFSPLDCMIKMVAQEGPTAFYKG 275
R GQ Y L CM+ V +EGP +KG
Sbjct: 244 RLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKG 277
Score = 74.3 bits (181), Expect = 1e-13
Identities = 65/214 (30%), Positives = 89/214 (41%), Gaps = 26/214 (12%)
Query: 8 DVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLV----------- 56
D PT A L + +T P + AKVRLQ Q + Q Q
Sbjct: 90 DAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCP 149
Query: 57 --------QYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQ-MSFASIRIGLYDSVKQVYT 107
+YRG L + T+ R EG C Y G A + R SFA+ + Y + + +
Sbjct: 150 VPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLS-YAVLCEWLS 208
Query: 108 PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYR 167
P G + ++AG G +A A P DV+K R QA + R+Y G +
Sbjct: 209 PAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQAD-----GQGQRRYRGLLHCMV 263
Query: 168 TIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYD 201
T REEG R L+KG + N R VN V Y+
Sbjct: 264 TSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYE 297
Score = 43.9 bits (102), Expect = 2e-04
Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 11/95 (11%)
Query: 8 DVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILT 67
DVP + + G A A V P+D K RLQ G+ Q +YRG+L ++T
Sbjct: 216 DVPGVL----VAGGCAGVLAWAVATPMDVIKSRLQADGQGQR-------RYRGLLHCMVT 264
Query: 68 MVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSV 102
VR EGP + GLV R + Y++V
Sbjct: 265 SVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAV 299
Score = 36.6 bits (83), Expect = 0.024
Identities = 42/187 (22%), Positives = 61/187 (32%), Gaps = 41/187 (21%)
Query: 121 LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK 180
+AG G V P D VKVR Q ++ KY+G R E V G ++
Sbjct: 4 VAGAIGGVCGVAVGYPLDTVKVRIQ---------TEPKYTGIWHCVRDTYHRERVWGFYR 54
Query: 181 GTLPNIMRNAIVNCAEVVTY-DILKEKLLDYHLLTDNFPCH---FVSAFGAGFCATVVAS 236
G + ++V+ TY L + D P +S +G + S
Sbjct: 55 GLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTS 114
Query: 237 PVDVVKTRYMNS----------------------------PPGQYFSPLDCMIKMVAQEG 268
P +V K R P +Y PL C+ + +EG
Sbjct: 115 PTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEG 174
Query: 269 PTAFYKG 275
YKG
Sbjct: 175 LCGLYKG 181
Score = 29.6 bits (65), Expect = 3.0
Identities = 17/55 (30%), Positives = 23/55 (41%), Gaps = 2/55 (3%)
Query: 221 FVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
FV+ G C V P+D VK R P +Y C+ +E FY+G
Sbjct: 3 FVAGAIGGVCGVAVGYPLDTVKVRIQTEP--KYTGIWHCVRDTYHRERVWGFYRG 55
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 88.6 bits (218), Expect = 5e-18
Identities = 77/277 (27%), Positives = 116/277 (41%), Gaps = 18/277 (6%)
Query: 5 KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64
+P + P L G V PLDT KVRLQ Q + Q Y G
Sbjct: 4 QPKPISPLK--NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPP---MYSGTFDC 58
Query: 65 ILTMVRTEGPCSPYNGLVA---GLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRIL 121
+ EG Y G+ A G+ + GL ++Q + D S
Sbjct: 59 FRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPE---DVLSYPQLFA 115
Query: 122 AGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKG 181
AG +G P + +K Q G S KY+GT+D + + +E G+RG++KG
Sbjct: 116 AGMLSGVFTTGIMTPGERIKCLLQIQASSGES----KYTGTLDCAKKLYQEFGIRGIYKG 171
Query: 182 TLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNF--PCHFVSAFGAGFCATVVASPVD 239
T+ +MR+ + +TY+ LK P V+ AG VA P D
Sbjct: 172 TVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPD 231
Query: 240 VVKTRYMNSPPGQYFSPL-DCMIKMVAQEGPTAFYKG 275
V+K+R+ +PPG+Y + D + +++ EG T+ YKG
Sbjct: 232 VLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKG 268
Score = 55.1 bits (131), Expect = 7e-08
Identities = 53/189 (28%), Positives = 81/189 (42%), Gaps = 16/189 (8%)
Query: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
F + F + P + K LQIQ + + Y G L + + G
Sbjct: 114 FAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESK------YTGTLDCAKKLYQEFGIRG 167
Query: 77 PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTT-RIL-AGCTTGAMAVTCA 134
Y G V L R + + + Y+ +K ++TP+G S L+ RIL AG G A
Sbjct: 168 IYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVA 227
Query: 135 QPTDVVKVRFQASIHLGPSRSDRKY-SGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVN 193
P DV+K RFQ + KY +G D R + R+EGV L+KG ++R N
Sbjct: 228 IPPDVLKSRFQTA-------PPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPAN 280
Query: 194 CAEVVTYDI 202
A + +++
Sbjct: 281 AACFLGFEV 289
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 87.4 bits (215), Expect = 1e-17
Identities = 69/283 (24%), Positives = 121/283 (42%), Gaps = 25/283 (8%)
Query: 7 SDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTIL 66
+D + A FL G AA + P++ K+ LQ+Q ++ + + QY+G++ ++
Sbjct: 2 TDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADK--QYKGIIDCVV 59
Query: 67 TMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSS-----LTTRIL 121
+ + +G S + G +A + R ++ D KQ++ G D + +
Sbjct: 60 RIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFL-GGVDKRTQFWLYFAGNLA 118
Query: 122 AGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKG 181
+G GA ++ P D + R A + G + ++R++ G D I + +G++GL++G
Sbjct: 119 SGGAAGATSLCFVYPLDFARTRLAADV--GKAGAEREFRGLGDCLVKIYKSDGIKGLYQG 176
Query: 182 TLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVAS----P 237
++ I A YD K +L D H V ++ T VA P
Sbjct: 177 FNVSVQGIIIYRAAYFGIYDTAK------GMLPDPKNTHIVISWMIAQTVTAVAGLTSYP 230
Query: 238 VDVVKTRYM-----NSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
D V+ R M Y LDC K+ EG AF+KG
Sbjct: 231 FDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKG 273
Score = 64.7 bits (156), Expect = 8e-11
Identities = 49/185 (26%), Positives = 89/185 (48%), Gaps = 15/185 (8%)
Query: 22 TAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGL 81
T+ CF +PLD A+ RL + ++RG+ ++ + +++G Y G
Sbjct: 126 TSLCFV----YPLDFARTRLAADVGKAGAER----EFRGLGDCLVKIYKSDGIKGLYQGF 177
Query: 82 VAGLQRQMSFASIRIGLYDSVKQVYT-PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVV 140
+Q + + + G+YD+ K + PK N+ + + T A+A + P D V
Sbjct: 178 NVSVQGIIIYRAAYFGIYDTAKGMLPDPK---NTHIVISWMIAQTVTAVAGLTSYPFDTV 234
Query: 141 KVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTY 200
+ R + G +D Y+GT+D +R IAR+EG + +KG N++R + +V Y
Sbjct: 235 RRRMM--MQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR-GMGGAFVLVLY 291
Query: 201 DILKE 205
D +K+
Sbjct: 292 DEIKK 296
Score = 38.5 bits (88), Expect = 0.006
Identities = 25/102 (24%), Positives = 46/102 (45%), Gaps = 5/102 (4%)
Query: 3 GLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVL 62
G+ P + + ++ A T A L ++P DT + R+ +Q + + Y G L
Sbjct: 200 GMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTD----IMYTGTL 255
Query: 63 GTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQ 104
+ R EG + + G + + R M A + + LYD +K+
Sbjct: 256 DCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLV-LYDEIKK 296
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 87.4 bits (215), Expect = 1e-17
Identities = 71/269 (26%), Positives = 113/269 (42%), Gaps = 21/269 (7%)
Query: 16 KFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPC 75
+F+ + ++ P DT KVRLQ Q YRG++ ++ + R E
Sbjct: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQ-----------TTYRGIVDCMVKIYRHESLL 53
Query: 76 SPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTP-----KGADNSSLTTRILAGCTTGAMA 130
+ G+ + S+ G+Y + V T + A S LAGCT G +
Sbjct: 54 GFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQ 113
Query: 131 VTCAQPTDVVKVRFQASIH--LGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMR 188
C P D++KVR Q P +Y G + +I REEG RGL++G +R
Sbjct: 114 AYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLR 173
Query: 189 NAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNS 248
+ +TY+ L + + F AG + V A+P+D++K+R
Sbjct: 174 DTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGF-AGIASWVAATPLDMIKSRMQMD 232
Query: 249 PPGQ--YFSPLDCMIKMVAQEGPTAFYKG 275
+ Y LDCM+ + QEG F++G
Sbjct: 233 GLRRRVYQGMLDCMVSSIRQEGLGVFFRG 261
Score = 72.4 bits (176), Expect = 4e-13
Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 6/194 (3%)
Query: 10 PPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMV 69
PP+ FL T P D KVRLQ Q E +A + +Y+G + ++
Sbjct: 96 PPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIF 155
Query: 70 RTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAM 129
R EGP + G A R I Y+ + + YTP+G + SS T ++AG G
Sbjct: 156 REEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATV-LVAGGFAGIA 214
Query: 130 AVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRN 189
+ A P D++K R Q G R R Y G +D + R+EG+ ++G N R
Sbjct: 215 SWVAATPLDMIKSRMQMD---GLRR--RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARA 269
Query: 190 AIVNCAEVVTYDIL 203
VN ++Y+ L
Sbjct: 270 FPVNAVTFLSYEYL 283
Score = 31.6 bits (70), Expect = 0.79
Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 7/68 (10%)
Query: 6 PSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTI 65
P P+ A + G A + + PLD K R+Q+ G + V Y+G+L +
Sbjct: 194 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRV-------YQGMLDCM 246
Query: 66 LTMVRTEG 73
++ +R EG
Sbjct: 247 VSSIRQEG 254
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 87.4 bits (215), Expect = 1e-17
Identities = 74/294 (25%), Positives = 114/294 (38%), Gaps = 33/294 (11%)
Query: 7 SDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTIL 66
+D ++ K + G A FP+D AK RLQ Q Q V Y + ++
Sbjct: 2 ADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-------YTSMSDCLI 54
Query: 67 TMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTT 126
VR+EG Y G L +I++ D + + K +L +LAGC
Sbjct: 55 KTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLS-KDGQKLTLLKEMLAGCGA 113
Query: 127 GAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAY-------------------- 166
G V P +++K++ Q + + R G + A
Sbjct: 114 GTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQL 173
Query: 167 -RTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAF 225
R + R G+ GL+KG ++R+ + + L + F F++
Sbjct: 174 TRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGC 233
Query: 226 GAGFCATVVASPVDVVKTRYMNSPPG----QYFSPLDCMIKMVAQEGPTAFYKG 275
AG A V +P DVVKTR + G Y LDC K++ EGP+AF KG
Sbjct: 234 VAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
Score = 69.3 bits (168), Expect = 3e-12
Identities = 61/212 (28%), Positives = 92/212 (43%), Gaps = 28/212 (13%)
Query: 19 GAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLG--------------- 63
G G C +VT P++ K++LQ G A + +++ +G L
Sbjct: 110 GCGAGTCQV-IVTTPMEMLKIQLQDAGRIAAQR--KILAAQGQLSAQGGAQPSVEAPAAP 166
Query: 64 ----TILT--MVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLT 117
T LT ++R+ G Y GL A L R + F+ + L+ ++ Q+ P + S
Sbjct: 167 RPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFY 226
Query: 118 TRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRG 177
LAGC G+ A P DVVK R Q+ L ++ YSG +D R I R EG
Sbjct: 227 VSFLAGCVAGSAAAVAVNPCDVVKTRLQS---LQRGVNEDTYSGILDCARKILRHEGPSA 283
Query: 178 LWKGTLPNIMRNA-IVNCAEVVTYDILKEKLL 208
KG + A + A+VV + + E LL
Sbjct: 284 FLKGAYCRALVIAPLFGIAQVVYFLGIAESLL 315
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 87.0 bits (214), Expect = 2e-17
Identities = 73/287 (25%), Positives = 118/287 (41%), Gaps = 33/287 (11%)
Query: 12 TMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRT 71
++ K + G A FP+D AK RLQ Q Y+G++ ++ R
Sbjct: 7 SITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGK--------AMYKGMIDCLMKTARA 58
Query: 72 EGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAV 131
EG Y G L +I++ D +++ G + L +LAGC G V
Sbjct: 59 EGFFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRN-LKMEMLAGCGAGMCQV 117
Query: 132 TCAQPTDVVKVRFQASIHL-------------------GPSRSDRKYSGTMDAYRTIARE 172
P +++K++ Q + L G + + R+ S T+ A+ + R
Sbjct: 118 VVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELL-RT 176
Query: 173 EGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCAT 232
+G+ GL++G ++R+ + + L + +F FVS AG A
Sbjct: 177 QGLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVSGCVAGSIAA 236
Query: 233 VVASPVDVVKTRYMNSPPG----QYFSPLDCMIKMVAQEGPTAFYKG 275
V +P+DV+KTR G Y DC K+ QEGP+AF KG
Sbjct: 237 VAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKG 283
>gi|55749577 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 4 [Homo
sapiens]
Length = 298
Score = 84.3 bits (207), Expect = 1e-16
Identities = 69/272 (25%), Positives = 115/272 (42%), Gaps = 23/272 (8%)
Query: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
FL G AA + P++ K+ LQ+Q ++ + + QY+G++ ++ + + +G S
Sbjct: 12 FLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEK--QYKGIIDCVVRIPKEQGFLS 69
Query: 77 PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILA-----GCTTGAMAV 131
+ G +A + R ++ D KQ++ G D R A G GA ++
Sbjct: 70 FWRGNLANVIRYFPTQALNFAFKDKYKQLFL-GGVDRHKQFWRYFAGNLASGGAAGATSL 128
Query: 132 TCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAI 191
P D + R A + G + R++ G D I + +G+RGL++G ++ I
Sbjct: 129 CFVYPLDFARTRLAADV--GKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIII 186
Query: 192 VNCAEVVTYDILKEKLLD---YHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYM-- 246
A YD K L D H+ V+A A +V+ P D V+ R M
Sbjct: 187 YRAAYFGVYDTAKGMLPDPKNVHIFVSWMIAQSVTA-----VAGLVSYPFDTVRRRMMMQ 241
Query: 247 ---NSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
Y +DC K+ EG AF+KG
Sbjct: 242 SGRKGADIMYTGTVDCWRKIAKDEGAKAFFKG 273
Score = 62.4 bits (150), Expect = 4e-10
Identities = 49/185 (26%), Positives = 88/185 (47%), Gaps = 15/185 (8%)
Query: 22 TAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGL 81
T+ CF +PLD A+ RL A Q ++ G+ I+ + +++G Y G
Sbjct: 126 TSLCFV----YPLDFARTRLAADVGKGAAQR----EFHGLGDCIIKIFKSDGLRGLYQGF 177
Query: 82 VAGLQRQMSFASIRIGLYDSVKQVYT-PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVV 140
+Q + + + G+YD+ K + PK N + + + A+A + P D V
Sbjct: 178 NVSVQGIIIYRAAYFGVYDTAKGMLPDPK---NVHIFVSWMIAQSVTAVAGLVSYPFDTV 234
Query: 141 KVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTY 200
+ R + G +D Y+GT+D +R IA++EG + +KG N++R + +V Y
Sbjct: 235 RRRMM--MQSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLR-GMGGAFVLVLY 291
Query: 201 DILKE 205
D +K+
Sbjct: 292 DEIKK 296
Score = 35.8 bits (81), Expect = 0.042
Identities = 24/102 (23%), Positives = 47/102 (46%), Gaps = 5/102 (4%)
Query: 3 GLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVL 62
G+ P + V ++ A + A LV++P DT + R+ +Q + + Y G +
Sbjct: 200 GMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGAD----IMYTGTV 255
Query: 63 GTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQ 104
+ + EG + + G + + R M A + + LYD +K+
Sbjct: 256 DCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLV-LYDEIKK 296
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 84.0 bits (206), Expect = 1e-16
Identities = 65/266 (24%), Positives = 118/266 (44%), Gaps = 15/266 (5%)
Query: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
L G AA + P++ K+ LQ+Q ++ + +Y+G++ ++ + R +G S
Sbjct: 25 LAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPE--ARYKGMVDCLVRIPREQGFFSF 82
Query: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTR-----ILAGCTTGAMAVT 132
+ G +A + R ++ D KQ++ G + R + +G GA ++
Sbjct: 83 WRGNLANVIRYFPTQALNFAFKDKYKQLFM-SGVNKEKQFWRWFLANLASGGAAGATSLC 141
Query: 133 CAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIV 192
P D + R I GP +R++ G D IA+ +G+ GL++G ++ +
Sbjct: 142 VVYPLDFARTRLGVDIGKGPE--ERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVY 199
Query: 193 NCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYM---NSP 249
+ YD +K LL T F F A C+ +++ P D V+ R M
Sbjct: 200 RASYFGAYDTVKG-LLPKPKKTP-FLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQSGEA 257
Query: 250 PGQYFSPLDCMIKMVAQEGPTAFYKG 275
QY LDC +K+ EG ++F++G
Sbjct: 258 KRQYKGTLDCFVKIYQHEGISSFFRG 283
Score = 61.2 bits (147), Expect = 9e-10
Identities = 47/186 (25%), Positives = 85/186 (45%), Gaps = 13/186 (6%)
Query: 21 GTAACFADLVTFPLDTAKVRLQIQ-GENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYN 79
G A + V +PLD A+ RL + G+ + Q++G+ I+ + +++G Y
Sbjct: 133 GAAGATSLCVVYPLDFARTRLGVDIGKGPEER-----QFKGLGDCIMKIAKSDGIAGLYQ 187
Query: 80 GLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDV 139
G +Q + + + G YD+VK + PK L + +A T + + P D
Sbjct: 188 GFGVSVQGIIVYRASYFGAYDTVKGLL-PKPKKTPFLVSFFIAQVVTTCSGIL-SYPFDT 245
Query: 140 VKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVT 199
V+ R + + R+Y GT+D + I + EG+ ++G N++R +V
Sbjct: 246 VRRRMM----MQSGEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGT-GGALVLVL 300
Query: 200 YDILKE 205
YD +KE
Sbjct: 301 YDKIKE 306
Score = 56.2 bits (134), Expect = 3e-08
Identities = 44/173 (25%), Positives = 68/173 (39%), Gaps = 9/173 (5%)
Query: 112 DNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAR 171
D SS +LAG A++ T P + VK+ Q + +Y G +D I R
Sbjct: 16 DASSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPR 75
Query: 172 EEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLD----YHLLTDNFPCHFVSAFGA 227
E+G W+G L N++R D K+ + F + S A
Sbjct: 76 EQGFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAA 135
Query: 228 GFCATVVASPVDVVKTR----YMNSPPGQYFSPL-DCMIKMVAQEGPTAFYKG 275
G + V P+D +TR P + F L DC++K+ +G Y+G
Sbjct: 136 GATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQG 188
Score = 37.7 bits (86), Expect = 0.011
Identities = 27/105 (25%), Positives = 48/105 (45%), Gaps = 9/105 (8%)
Query: 3 GLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQ-GENQAVQTARLVQYRGV 61
GL P V F A + ++++P DT + R+ +Q GE + QY+G
Sbjct: 212 GLLPKPKKTPFLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQSGEAKR-------QYKGT 264
Query: 62 LGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVY 106
L + + + EG S + G + + R A + + LYD +K+ +
Sbjct: 265 LDCFVKIYQHEGISSFFRGAFSNVLRGTGGALVLV-LYDKIKEFF 308
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 83.6 bits (205), Expect = 2e-16
Identities = 68/263 (25%), Positives = 118/263 (44%), Gaps = 19/263 (7%)
Query: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
L G A +TFP + K +LQ+ + + +YRG+ + VR+ G
Sbjct: 30 LAGGLAGGIEICITFPTEYVKTQLQLD------ERSHPPRYRGIGDCVRQTVRSHGVLGL 83
Query: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTG-AMAVTCAQP 136
Y GL + L + A++R G+++ + + T +L G G A AV P
Sbjct: 84 YRGLSSLLYGSIPKAAVRFGMFEFLSN-HMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142
Query: 137 TDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAE 196
+ +KV+F IH + + KY G R I RE+G++G ++G +++ +
Sbjct: 143 METIKVKF---IH-DQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQG---SNQ 195
Query: 197 VVTYDILKEKLLDYHLLTDNFPCH--FVSAFGA--GFCATVVASPVDVVKTRYMNSPPGQ 252
+ + ++ Y N P + FGA G + +P+DV+KTR +
Sbjct: 196 AIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHK 255
Query: 253 YFSPLDCMIKMVAQEGPTAFYKG 275
Y + DC ++++ +EG AFYKG
Sbjct: 256 YRNTWDCGLQILKKEGLKAFYKG 278
Score = 65.5 bits (158), Expect = 5e-11
Identities = 57/187 (30%), Positives = 84/187 (44%), Gaps = 20/187 (10%)
Query: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
LGAG A A +V P++T KV+ QT+ +YRG + +VR +G
Sbjct: 129 LGAGVAE--AVVVVCPMETIKVKFIHD------QTSPNPKYRGFFHGVREIVREQGLKGT 180
Query: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVY---TPKGADNSSLTTRILAGCTTGAMAVTCA 134
Y GL A + +Q S +IR + S++ Y P N +T + G GA +V
Sbjct: 181 YQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITG--VFGAIAGAASVFGN 238
Query: 135 QPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNC 194
P DV+K R Q KY T D I ++EG++ +KGT+P + R +
Sbjct: 239 TPLDVIKTRMQGL-------EAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVA 291
Query: 195 AEVVTYD 201
V YD
Sbjct: 292 IVFVIYD 298
Score = 47.4 bits (111), Expect = 1e-05
Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 11/161 (6%)
Query: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179
ILAG G + + PT+ VK + Q P R Y G D R R GV GL+
Sbjct: 29 ILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPR----YRGIGDCVRQTVRSHGVLGLY 84
Query: 180 KGTLPNIMRNAIVNCA-EVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFC-ATVVASP 237
+G L +++ +I A ++ L + D D+ + GAG A VV P
Sbjct: 85 RG-LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDS-TRGLLCGLGAGVAEAVVVVCP 142
Query: 238 VDVVKTRYMN---SPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
++ +K ++++ SP +Y + ++V ++G Y+G
Sbjct: 143 METIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQG 183
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 83.6 bits (205), Expect = 2e-16
Identities = 62/200 (31%), Positives = 94/200 (47%), Gaps = 17/200 (8%)
Query: 5 KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64
K VP +A + L G A + T PL+ K+RLQ+ GE + T V +
Sbjct: 422 KDGSVP--LAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGE---ITTGPRV-------S 469
Query: 65 ILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC 124
L++VR G Y G A R + F++I Y VK + + S + +LAG
Sbjct: 470 ALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSP-GSLLLAGA 528
Query: 125 TTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184
G A + P DV+K R Q + G + YSG +D +R I REEG + LWKG
Sbjct: 529 IAGMPAASLVTPADVIKTRLQVAARAGQTT----YSGVIDCFRKILREEGPKALWKGAGA 584
Query: 185 NIMRNAIVNCAEVVTYDILK 204
+ R++ ++TY++L+
Sbjct: 585 RVFRSSPQFGVTLLTYELLQ 604
Score = 66.2 bits (160), Expect = 3e-11
Identities = 64/265 (24%), Positives = 108/265 (40%), Gaps = 15/265 (5%)
Query: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEG 73
A +F A +P+D K R+Q Q + + Y+ ++R EG
Sbjct: 329 AYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGE--LMYKNSFDCFKKVLRYEG 386
Query: 74 PCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTC 133
Y GL+ L +I++ + D V+ + K + L ILAG G V
Sbjct: 387 FFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDG-SVPLAAEILAGGCAGGSQVIF 445
Query: 134 AQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVN 193
P ++VK+R Q + + +G + ++ R+ G G++KG +R+ +
Sbjct: 446 TNPLEIVKIRLQVAGEIT--------TGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFS 497
Query: 194 CAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRY-MNSPPGQ 252
Y +K + A AG A + +P DV+KTR + + GQ
Sbjct: 498 AIYFPCYAHVKASFANEDGQVSPGSLLLAGAI-AGMPAASLVTPADVIKTRLQVAARAGQ 556
Query: 253 --YFSPLDCMIKMVAQEGPTAFYKG 275
Y +DC K++ +EGP A +KG
Sbjct: 557 TTYSGVIDCFRKILREEGPKALWKG 581
Score = 29.3 bits (64), Expect = 3.9
Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 7/78 (8%)
Query: 27 ADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQ 86
A LVT P D K RLQ+ +A QT Y GV+ ++R EGP + + G A +
Sbjct: 535 ASLVT-PADVIKTRLQVAA--RAGQTT----YSGVIDCFRKILREEGPKALWKGAGARVF 587
Query: 87 RQMSFASIRIGLYDSVKQ 104
R + + Y+ +++
Sbjct: 588 RSSPQFGVTLLTYELLQR 605
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 83.6 bits (205), Expect = 2e-16
Identities = 62/200 (31%), Positives = 94/200 (47%), Gaps = 17/200 (8%)
Query: 5 KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64
K VP +A + L G A + T PL+ K+RLQ+ GE + T V +
Sbjct: 423 KDGSVP--LAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGE---ITTGPRV-------S 470
Query: 65 ILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC 124
L++VR G Y G A R + F++I Y VK + + S + +LAG
Sbjct: 471 ALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSP-GSLLLAGA 529
Query: 125 TTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184
G A + P DV+K R Q + G + YSG +D +R I REEG + LWKG
Sbjct: 530 IAGMPAASLVTPADVIKTRLQVAARAGQTT----YSGVIDCFRKILREEGPKALWKGAGA 585
Query: 185 NIMRNAIVNCAEVVTYDILK 204
+ R++ ++TY++L+
Sbjct: 586 RVFRSSPQFGVTLLTYELLQ 605
Score = 66.2 bits (160), Expect = 3e-11
Identities = 64/265 (24%), Positives = 108/265 (40%), Gaps = 15/265 (5%)
Query: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEG 73
A +F A +P+D K R+Q Q + + Y+ ++R EG
Sbjct: 330 AYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGE--LMYKNSFDCFKKVLRYEG 387
Query: 74 PCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTC 133
Y GL+ L +I++ + D V+ + K + L ILAG G V
Sbjct: 388 FFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDG-SVPLAAEILAGGCAGGSQVIF 446
Query: 134 AQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVN 193
P ++VK+R Q + + +G + ++ R+ G G++KG +R+ +
Sbjct: 447 TNPLEIVKIRLQVAGEIT--------TGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFS 498
Query: 194 CAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRY-MNSPPGQ 252
Y +K + A AG A + +P DV+KTR + + GQ
Sbjct: 499 AIYFPCYAHVKASFANEDGQVSPGSLLLAGAI-AGMPAASLVTPADVIKTRLQVAARAGQ 557
Query: 253 --YFSPLDCMIKMVAQEGPTAFYKG 275
Y +DC K++ +EGP A +KG
Sbjct: 558 TTYSGVIDCFRKILREEGPKALWKG 582
Score = 55.5 bits (132), Expect = 5e-08
Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 15/196 (7%)
Query: 51 QTARLVQYRG--VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTP 108
Q A L + RG L I + E P+N A Q++ S S R L + Y
Sbjct: 274 QLADLYEPRGRMTLADIERIAPLEEGTLPFNLAEAQRQQKASGDSARPVLLQVAESAY-- 331
Query: 109 KGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRT 168
R G GA+ T P D+VK R Q G + Y + D ++
Sbjct: 332 ----------RFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKK 381
Query: 169 IAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAG 228
+ R EG GL++G LP ++ A ++ D +++K + + + ++ AG
Sbjct: 382 VLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFM-HKDGSVPLAAEILAGGCAG 440
Query: 229 FCATVVASPVDVVKTR 244
+ +P+++VK R
Sbjct: 441 GSQVIFTNPLEIVKIR 456
Score = 29.3 bits (64), Expect = 3.9
Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 7/78 (8%)
Query: 27 ADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQ 86
A LVT P D K RLQ+ +A QT Y GV+ ++R EGP + + G A +
Sbjct: 536 ASLVT-PADVIKTRLQVAA--RAGQTT----YSGVIDCFRKILREEGPKALWKGAGARVF 588
Query: 87 RQMSFASIRIGLYDSVKQ 104
R + + Y+ +++
Sbjct: 589 RSSPQFGVTLLTYELLQR 606
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 82.0 bits (201), Expect = 5e-16
Identities = 56/185 (30%), Positives = 86/185 (46%), Gaps = 16/185 (8%)
Query: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEG 73
+V F+ G AAC A L P+D + R QGE + T R + TM R+EG
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLR--------HAVGTMYRSEG 170
Query: 74 PCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVY----TPKGADNSSLTTRILAGCTTGAM 129
P Y GL L +A ++ Y S+K +Y +G N +L +L G G +
Sbjct: 171 PQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGVI 229
Query: 130 AVTCAQPTDVVKVRFQAS--IHLGPSRSD-RKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186
+ T P D+ K R Q H + R+Y G MD + + ++EG G +KG P++
Sbjct: 230 SKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSL 289
Query: 187 MRNAI 191
++ A+
Sbjct: 290 LKAAL 294
Score = 79.7 bits (195), Expect = 3e-15
Identities = 58/173 (33%), Positives = 84/173 (48%), Gaps = 8/173 (4%)
Query: 108 PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSD--RKYSGTMDA 165
P G +N+ + AG +G + P DV+K+RFQ H SRSD KY G + A
Sbjct: 8 PDGRNNTKFQVAV-AGSVSGLVTRALISPFDVIKIRFQLQ-HERLSRSDPSAKYHGILQA 65
Query: 166 YRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTD--NFPCHFVS 223
R I +EEG WKG +P + + + +++++L E L+ + D F HFV
Sbjct: 66 SRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTE-LVHRGSVYDAREFSVHFVC 124
Query: 224 AFGAGFCATVVASPVDVVKTRY-MNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
A AT+ PVDV++TR+ P Y + + M EGP FYKG
Sbjct: 125 GGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKG 177
Score = 60.5 bits (145), Expect = 2e-09
Identities = 58/263 (22%), Positives = 106/263 (40%), Gaps = 33/263 (12%)
Query: 33 PLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFA 92
P D K+R Q+Q E + ++ +Y G+L +++ EGP + + G V + +
Sbjct: 35 PFDVIKIRFQLQHERLS-RSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYG 93
Query: 93 SIRIGLYDSVKQ-VYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLG 151
+++ ++ + + V+ D + + G MA P DV++ RF A
Sbjct: 94 AVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ---- 149
Query: 152 PSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYH 211
+ Y+ A T+ R EG + +KG P ++ + Y LK H
Sbjct: 150 --GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLK------H 201
Query: 212 LLTDNFPC---------HFVSAFGAGFCATVVASPVDVVKTR-------YMNSPPGQ--- 252
L P + + GAG + + P+D+ K R + + GQ
Sbjct: 202 LYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRR 261
Query: 253 YFSPLDCMIKMVAQEGPTAFYKG 275
Y +DC +++ +EG F+KG
Sbjct: 262 YKGLMDCAKQVLQKEGALGFFKG 284
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 82.0 bits (201), Expect = 5e-16
Identities = 56/185 (30%), Positives = 86/185 (46%), Gaps = 16/185 (8%)
Query: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEG 73
+V F+ G AAC A L P+D + R QGE + T R + TM R+EG
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLR--------HAVGTMYRSEG 170
Query: 74 PCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVY----TPKGADNSSLTTRILAGCTTGAM 129
P Y GL L +A ++ Y S+K +Y +G N +L +L G G +
Sbjct: 171 PQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGVI 229
Query: 130 AVTCAQPTDVVKVRFQAS--IHLGPSRSD-RKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186
+ T P D+ K R Q H + R+Y G MD + + ++EG G +KG P++
Sbjct: 230 SKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSL 289
Query: 187 MRNAI 191
++ A+
Sbjct: 290 LKAAL 294
Score = 79.7 bits (195), Expect = 3e-15
Identities = 58/173 (33%), Positives = 84/173 (48%), Gaps = 8/173 (4%)
Query: 108 PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSD--RKYSGTMDA 165
P G +N+ + AG +G + P DV+K+RFQ H SRSD KY G + A
Sbjct: 8 PDGRNNTKFQVAV-AGSVSGLVTRALISPFDVIKIRFQLQ-HERLSRSDPSAKYHGILQA 65
Query: 166 YRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTD--NFPCHFVS 223
R I +EEG WKG +P + + + +++++L E L+ + D F HFV
Sbjct: 66 SRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTE-LVHRGSVYDAREFSVHFVC 124
Query: 224 AFGAGFCATVVASPVDVVKTRY-MNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
A AT+ PVDV++TR+ P Y + + M EGP FYKG
Sbjct: 125 GGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKG 177
Score = 60.5 bits (145), Expect = 2e-09
Identities = 58/263 (22%), Positives = 106/263 (40%), Gaps = 33/263 (12%)
Query: 33 PLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFA 92
P D K+R Q+Q E + ++ +Y G+L +++ EGP + + G V + +
Sbjct: 35 PFDVIKIRFQLQHERLS-RSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYG 93
Query: 93 SIRIGLYDSVKQ-VYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLG 151
+++ ++ + + V+ D + + G MA P DV++ RF A
Sbjct: 94 AVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ---- 149
Query: 152 PSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYH 211
+ Y+ A T+ R EG + +KG P ++ + Y LK H
Sbjct: 150 --GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLK------H 201
Query: 212 LLTDNFPC---------HFVSAFGAGFCATVVASPVDVVKTR-------YMNSPPGQ--- 252
L P + + GAG + + P+D+ K R + + GQ
Sbjct: 202 LYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRR 261
Query: 253 YFSPLDCMIKMVAQEGPTAFYKG 275
Y +DC +++ +EG F+KG
Sbjct: 262 YKGLMDCAKQVLQKEGALGFFKG 284
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 82.0 bits (201), Expect = 5e-16
Identities = 56/185 (30%), Positives = 86/185 (46%), Gaps = 16/185 (8%)
Query: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEG 73
+V F+ G AAC A L P+D + R QGE + T R + TM R+EG
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLR--------HAVGTMYRSEG 170
Query: 74 PCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVY----TPKGADNSSLTTRILAGCTTGAM 129
P Y GL L +A ++ Y S+K +Y +G N +L +L G G +
Sbjct: 171 PQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGVI 229
Query: 130 AVTCAQPTDVVKVRFQAS--IHLGPSRSD-RKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186
+ T P D+ K R Q H + R+Y G MD + + ++EG G +KG P++
Sbjct: 230 SKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSL 289
Query: 187 MRNAI 191
++ A+
Sbjct: 290 LKAAL 294
Score = 79.7 bits (195), Expect = 3e-15
Identities = 58/173 (33%), Positives = 84/173 (48%), Gaps = 8/173 (4%)
Query: 108 PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSD--RKYSGTMDA 165
P G +N+ + AG +G + P DV+K+RFQ H SRSD KY G + A
Sbjct: 8 PDGRNNTKFQVAV-AGSVSGLVTRALISPFDVIKIRFQLQ-HERLSRSDPSAKYHGILQA 65
Query: 166 YRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTD--NFPCHFVS 223
R I +EEG WKG +P + + + +++++L E L+ + D F HFV
Sbjct: 66 SRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTE-LVHRGSVYDAREFSVHFVC 124
Query: 224 AFGAGFCATVVASPVDVVKTRY-MNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
A AT+ PVDV++TR+ P Y + + M EGP FYKG
Sbjct: 125 GGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKG 177
Score = 60.5 bits (145), Expect = 2e-09
Identities = 58/263 (22%), Positives = 106/263 (40%), Gaps = 33/263 (12%)
Query: 33 PLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFA 92
P D K+R Q+Q E + ++ +Y G+L +++ EGP + + G V + +
Sbjct: 35 PFDVIKIRFQLQHERLS-RSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYG 93
Query: 93 SIRIGLYDSVKQ-VYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLG 151
+++ ++ + + V+ D + + G MA P DV++ RF A
Sbjct: 94 AVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ---- 149
Query: 152 PSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYH 211
+ Y+ A T+ R EG + +KG P ++ + Y LK H
Sbjct: 150 --GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLK------H 201
Query: 212 LLTDNFPC---------HFVSAFGAGFCATVVASPVDVVKTR-------YMNSPPGQ--- 252
L P + + GAG + + P+D+ K R + + GQ
Sbjct: 202 LYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRR 261
Query: 253 YFSPLDCMIKMVAQEGPTAFYKG 275
Y +DC +++ +EG F+KG
Sbjct: 262 YKGLMDCAKQVLQKEGALGFFKG 284
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 80.1 bits (196), Expect = 2e-15
Identities = 77/270 (28%), Positives = 115/270 (42%), Gaps = 27/270 (10%)
Query: 13 MAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTE 72
MA+ FL LV P DT KVRLQ VQ+ QYRG L ++++ E
Sbjct: 1 MALDFLAGCAGGVAGVLVGHPFDTVKVRLQ-------VQSVEKPQYRGTLHCFKSIIKQE 53
Query: 73 GPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVT 132
Y GL + L ++ G+ Q T + + S + LAG GA+
Sbjct: 54 SVLGLYKGLGSPLMGLTFINALVFGV-----QGNTLRALGHDSPLNQFLAGAAAGAIQCV 108
Query: 133 CAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIV 192
P ++ K R Q GP+R+ Y G++D I EG+RG+ +G + ++R
Sbjct: 109 ICCPMELAKTRLQLQ-DAGPART---YKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPS 164
Query: 193 NCAEVVTYDILKEKL---LDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRY---- 245
+TYD L L LL P ++ +G + + PVDVVK+R
Sbjct: 165 FGVYFLTYDALTRALGCEPGDRLLV---PKLLLAGGTSGIVSWLSTYPVDVVKSRLQADG 221
Query: 246 MNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
+ P +Y LDC+ + EG F +G
Sbjct: 222 LRGAP-RYRGILDCVHQSYRAEGWRVFTRG 250
Score = 64.3 bits (155), Expect = 1e-10
Identities = 51/188 (27%), Positives = 79/188 (42%), Gaps = 10/188 (5%)
Query: 16 KFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPC 75
+FL A ++ P++ AK RLQ+Q A Y+G L + + EG
Sbjct: 95 QFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPART------YKGSLDCLAQIYGHEGLR 148
Query: 76 SPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQ 135
G+V+ L R+ + YD++ + + D + +LAG T+G ++
Sbjct: 149 GVNRGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTY 208
Query: 136 PTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195
P DVVK R QA G R Y G +D R EG R +G ++R VN A
Sbjct: 209 PVDVVKSRLQADGLRGAPR----YRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAA 264
Query: 196 EVVTYDIL 203
T ++
Sbjct: 265 TFATVTVV 272
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 79.0 bits (193), Expect = 4e-15
Identities = 56/192 (29%), Positives = 86/192 (44%), Gaps = 15/192 (7%)
Query: 13 MAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTE 72
+ + L G A + T PL+ K+RLQ+ GE + T V + L ++R
Sbjct: 426 LPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGE---ITTGPRV-------SALNVLRDL 475
Query: 73 GPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVT 132
G Y G A R + F++I +Y K + + L + AG G A +
Sbjct: 476 GIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNL-LAAGAMAGVPAAS 534
Query: 133 CAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIV 192
P DV+K R Q + G + YSG +D +R I REEG WKGT + R++
Sbjct: 535 LVTPADVIKTRLQVAARAGQTT----YSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQ 590
Query: 193 NCAEVVTYDILK 204
+VTY++L+
Sbjct: 591 FGVTLVTYELLQ 602
Score = 76.3 bits (186), Expect = 3e-14
Identities = 68/265 (25%), Positives = 114/265 (43%), Gaps = 15/265 (5%)
Query: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEG 73
A +F A +P+D K R+Q Q + +V + Y+ ++R EG
Sbjct: 327 AYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGE--LMYKNSFDCFKKVLRYEG 384
Query: 74 PCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTC 133
Y GL+ L +I++ + D V+ +T + + L +LAG G V
Sbjct: 385 FFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDG-SVPLPAEVLAGGCAGGSQVIF 443
Query: 134 AQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVN 193
P ++VK+R Q + + +G + + R+ G+ GL+KG +R+ +
Sbjct: 444 TNPLEIVKIRLQVAGEIT--------TGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFS 495
Query: 194 CAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRY-MNSPPGQ 252
Y K L D + A AG A + +P DV+KTR + + GQ
Sbjct: 496 AIYFPVYAHCKLLLADENGHVGGLNLLAAGAM-AGVPAASLVTPADVIKTRLQVAARAGQ 554
Query: 253 --YFSPLDCMIKMVAQEGPTAFYKG 275
Y +DC K++ +EGP+AF+KG
Sbjct: 555 TTYSGVIDCFRKILREEGPSAFWKG 579
Score = 53.5 bits (127), Expect = 2e-07
Identities = 42/168 (25%), Positives = 68/168 (40%), Gaps = 15/168 (8%)
Query: 77 PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136
PYN +A LQRQ S R + Y R G GA+ T P
Sbjct: 301 PYN--LAELQRQQSPGLGRPIWLQIAESAY------------RFTLGSVAGAVGATAVYP 346
Query: 137 TDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAE 196
D+VK R Q G + Y + D ++ + R EG GL++G +P ++ A +
Sbjct: 347 IDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIK 406
Query: 197 VVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTR 244
+ D +++K P ++ AG + +P+++VK R
Sbjct: 407 LTVNDFVRDKFTRRDGSVP-LPAEVLAGGCAGGSQVIFTNPLEIVKIR 453
Score = 32.0 bits (71), Expect = 0.60
Identities = 26/86 (30%), Positives = 40/86 (46%), Gaps = 7/86 (8%)
Query: 19 GAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPY 78
GA A LVT P D K RLQ+ +A QT Y GV+ ++R EGP + +
Sbjct: 525 GAMAGVPAASLVT-PADVIKTRLQVAA--RAGQTT----YSGVIDCFRKILREEGPSAFW 577
Query: 79 NGLVAGLQRQMSFASIRIGLYDSVKQ 104
G A + R + + Y+ +++
Sbjct: 578 KGTAARVFRSSPQFGVTLVTYELLQR 603
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 73.9 bits (180), Expect = 1e-13
Identities = 50/156 (32%), Positives = 79/156 (50%), Gaps = 7/156 (4%)
Query: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179
++AG GA++ TC P D +KV Q +H S + G + + + RE G R LW
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQ--VHASRSNN----MGIVGGFTQMIREGGARSLW 243
Query: 180 KGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVD 239
+G N+++ A + + + Y+ +K +L+ T V+ AG A P++
Sbjct: 244 RGNGINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPME 302
Query: 240 VVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
V+KTR GQY LDC +++A+EG AFYKG
Sbjct: 303 VLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKG 338
Score = 72.8 bits (177), Expect = 3e-13
Identities = 60/232 (25%), Positives = 103/232 (44%), Gaps = 23/232 (9%)
Query: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
+ G A + T PLD KV +Q+ G++G M+R G S
Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRS--------NNMGIVGGFTQMIREGGARSL 242
Query: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTT--RILAGCTTGAMAVTCAQ 135
+ G + + ++I+ Y+ +K++ G+D +L R++AG GA+A +
Sbjct: 243 WRGNGINVLKIAPESAIKFMAYEQIKRLV---GSDQETLRIHERLVAGSLAGAIAQSSIY 299
Query: 136 PTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195
P +V+K R R +YSG +D R I EGV +KG +PN++
Sbjct: 300 PMEVLKTRMAL-------RKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGI 352
Query: 196 EVVTYDILKEKLLDYHLLTDNFPCHFV-SAFG--AGFCATVVASPVDVVKTR 244
++ Y+ LK L ++ + P FV A G + C + + P+ +V+TR
Sbjct: 353 DLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTR 404
Score = 57.4 bits (137), Expect = 1e-08
Identities = 48/194 (24%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 16 KFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPC 75
+ + A A +P++ K R+ ++ + QY G+L ++ EG
Sbjct: 283 RLVAGSLAGAIAQSSIYPMEVLKTRMALR---------KTGQYSGMLDCARRILAREGVA 333
Query: 76 SPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLT-TRILAGCTTGAMAVTCA 134
+ Y G V + + +A I + +Y+++K + A NS+ +L C G M+ TC
Sbjct: 334 AFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLAC--GTMSSTCG 391
Query: 135 Q----PTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNA 190
Q P +V+ R QA + + S ++ I R EG GL++G PN M+
Sbjct: 392 QLASYPLALVRTRMQAQASIEGAPEVTMSS----LFKHILRTEGAFGLYRGLAPNFMKVI 447
Query: 191 IVNCAEVVTYDILK 204
V Y+ LK
Sbjct: 448 PAVSISYVVYENLK 461
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,992,050
Number of Sequences: 37866
Number of extensions: 389036
Number of successful extensions: 1203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 665
Number of HSP's gapped (non-prelim): 216
length of query: 275
length of database: 18,247,518
effective HSP length: 101
effective length of query: 174
effective length of database: 14,423,052
effective search space: 2509611048
effective search space used: 2509611048
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.