Guide to the Human Genome
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Search of human proteins with 21389405

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens]
         (370 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens]        753   0.0  
gi|41281811 NADPH oxidase organizer 1 isoform b [Homo sapiens]        749   0.0  
gi|41281828 NADPH oxidase organizer 1 isoform c [Homo sapiens]        743   0.0  
gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens]             102   5e-22
gi|55749544 SH3 multiple domains 1 [Homo sapiens]                      92   7e-19
gi|63055059 SH3 and PX domains 2B [Homo sapiens]                       81   1e-15
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                49   9e-06
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                49   9e-06
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    48   1e-05
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    48   1e-05
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                    48   1e-05
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]             45   8e-05
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]             45   8e-05
gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]                45   8e-05
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...    45   1e-04
gi|5453754 NCK adaptor protein 1 [Homo sapiens]                        43   4e-04
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik...    42   9e-04
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...    42   9e-04
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]         42   9e-04
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]         42   9e-04
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]         42   9e-04
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap...    41   0.002
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...    40   0.003
gi|23308553 spermatogenesis associated 13 [Homo sapiens]               40   0.003
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap...    40   0.004
gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens]              40   0.004
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]               39   0.006
gi|157266298 anti-Mullerian hormone [Homo sapiens]                     39   0.007
gi|155723000 mixed lineage kinase 4 [Homo sapiens]                     39   0.007
gi|23510413 sorting nexin 26 [Homo sapiens]                            39   0.010

>gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens]
          Length = 370

 Score =  753 bits (1945), Expect = 0.0
 Identities = 370/370 (100%), Positives = 370/370 (100%)

Query: 1   MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKTLKETFPVEAG 60
           MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKTLKETFPVEAG
Sbjct: 1   MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKTLKETFPVEAG 60

Query: 61  LLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAP 120
           LLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAP
Sbjct: 61  LLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAP 120

Query: 121 QPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQA 180
           QPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQA
Sbjct: 121 QPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQA 180

Query: 181 QAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASR 240
           QAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASR
Sbjct: 181 QAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASR 240

Query: 241 AYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFR 300
           AYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFR
Sbjct: 241 AYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFR 300

Query: 301 GGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCV 360
           GGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCV
Sbjct: 301 GGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCV 360

Query: 361 DSVPHPTTEQ 370
           DSVPHPTTEQ
Sbjct: 361 DSVPHPTTEQ 370


>gi|41281811 NADPH oxidase organizer 1 isoform b [Homo sapiens]
          Length = 371

 Score =  749 bits (1933), Expect = 0.0
 Identities = 370/371 (99%), Positives = 370/371 (99%), Gaps = 1/371 (0%)

Query: 1   MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLK-TLKETFPVEA 59
           MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLK TLKETFPVEA
Sbjct: 1   MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEA 60

Query: 60  GLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFA 119
           GLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFA
Sbjct: 61  GLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFA 120

Query: 120 PQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQ 179
           PQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQ
Sbjct: 121 PQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQ 180

Query: 180 AQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCAS 239
           AQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCAS
Sbjct: 181 AQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCAS 240

Query: 240 RAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGF 299
           RAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGF
Sbjct: 241 RAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGF 300

Query: 300 RGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGC 359
           RGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGC
Sbjct: 301 RGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGC 360

Query: 360 VDSVPHPTTEQ 370
           VDSVPHPTTEQ
Sbjct: 361 VDSVPHPTTEQ 371


>gi|41281828 NADPH oxidase organizer 1 isoform c [Homo sapiens]
          Length = 376

 Score =  743 bits (1917), Expect = 0.0
 Identities = 370/376 (98%), Positives = 370/376 (98%), Gaps = 6/376 (1%)

Query: 1   MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLK-TLKETFPVEA 59
           MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLK TLKETFPVEA
Sbjct: 1   MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEA 60

Query: 60  GLLRRSDRVLPKLL-----DAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTI 114
           GLLRRSDRVLPKLL     DAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTI
Sbjct: 61  GLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTI 120

Query: 115 TGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTR 174
           TGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTR
Sbjct: 121 TGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTR 180

Query: 175 DRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP 234
           DRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP
Sbjct: 181 DRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP 240

Query: 235 QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL 294
           QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL
Sbjct: 241 QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL 300

Query: 295 SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQG 354
           SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQG
Sbjct: 301 SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQG 360

Query: 355 RPRGCVDSVPHPTTEQ 370
           RPRGCVDSVPHPTTEQ
Sbjct: 361 RPRGCVDSVPHPTTEQ 376


>gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens]
          Length = 390

 Score =  102 bits (254), Expect = 5e-22
 Identities = 93/371 (25%), Positives = 153/371 (41%), Gaps = 58/371 (15%)

Query: 24  FAFSVRWSDGSDTFVRRSWDEFRQL-KTLKETFPVEAGLLRRSDRVLPKLLDAPLLGRVG 82
           + F V+W D S+  V R + E  +  KTLKE FP+EAG +   +R++P L  AP      
Sbjct: 26  YMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHL-PAPKWFDGQ 84

Query: 83  RTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEE 142
           R +    R   L  Y   L++   +++R P +  FF  +P DL+  LP  ++   P    
Sbjct: 85  RAAEN--RQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLK--LPTDNQTKKPETYL 140

Query: 143 QPLSRAAGRLSIHS-LEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVEN 201
            P    +    I   +  Q+ R +  +  + T          + ++V+ +  SGWW  + 
Sbjct: 141 MPKDGKSTATDITGPIILQTYRAIANY--EKTSGSEMALSTGDVVEVVEKSESGWWFCQM 198

Query: 202 EDRQTAWFPAPYLEEA-APGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRV 260
           + ++  W PA +LE   +P +  +  P+   +G  + A +AY +   DE+S+  G  V V
Sbjct: 199 KAKR-GWIPASFLEPLDSPDETEDPEPNY--AGEPYVAIKAYTAVEGDEVSLLEGEAVEV 255

Query: 261 LETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDP--------------- 305
           +     GWW+ R  D  G  P++ L+  G     +    + G  P               
Sbjct: 256 IHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRS 315

Query: 306 --------------------AGEARGFPE----------PSQATAPPPTVPTRPSPGAIQ 335
                                 +AR  P+           +Q + P P VP RPS   I 
Sbjct: 316 RKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLIL 375

Query: 336 SRCCTVTRRAL 346
           +RC   T+R L
Sbjct: 376 NRCSESTKRKL 386


>gi|55749544 SH3 multiple domains 1 [Homo sapiens]
          Length = 1105

 Score = 92.0 bits (227), Expect = 7e-19
 Identities = 73/292 (25%), Positives = 124/292 (42%), Gaps = 19/292 (6%)

Query: 10  VQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKT-LKETFPVEAGLL 62
           VQ A +V +++ +       +  +V WSD +   + R + +F  L+  L + FP+E G  
Sbjct: 6   VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQK 65

Query: 63  RRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQP 122
               R++P L    L  R       + RL+ ++ Y R L+     +++   +  FF  +P
Sbjct: 66  DPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARP 125

Query: 123 LDLEP-----ALPPGSRVILPTPEEQPLSRAAGR-LSIHSLEAQSLRCLQPFCTQDTRDR 176
            D+ P            V L +  E P     G   +   +  +    +  +  Q+  + 
Sbjct: 126 EDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSE- 184

Query: 177 PFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQ- 235
               QA E +DV+ ++ SGWW V   + Q  W PA YL EA  G   +   +   +G + 
Sbjct: 185 -LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYL-EAQNGTRDDSDINTSKTGEEE 241

Query: 236 -FCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 286
            +   + Y S   DE+    G  V V+  +  GWW  RY  + G  PA  L+
Sbjct: 242 KYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLK 293



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 15/107 (14%)

Query: 241 AYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL------RPEGLGALL 294
           AY+  +  E+S PAG  V+VLE  + GWW  R+G+  G  P+  L      +P+  G  L
Sbjct: 822 AYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKEL 881

Query: 295 SGTGFRGGDDPA---------GEARGFPEPSQATAPPPTVPTRPSPG 332
                +G  +              +     +Q+    P +P++P  G
Sbjct: 882 DTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGG 928



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 9/113 (7%)

Query: 235 QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL 294
           Q+     Y+     ELS+ AG  V V+E ++ GWW     +  G +PA  L  +      
Sbjct: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQ------ 223

Query: 295 SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALE 347
           +GT     D     ++   E    T  P T  ++   G  +     V R+ LE
Sbjct: 224 NGT---RDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLE 273



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 13/35 (37%), Positives = 22/35 (62%), Gaps = 3/35 (8%)

Query: 185  SLDVLLRHPSGWW---LVENEDRQTAWFPAPYLEE 216
            S++VL R+P+GWW   +++       W P+ YLE+
Sbjct: 1069 SMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103


>gi|63055059 SH3 and PX domains 2B [Homo sapiens]
          Length = 911

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 63/271 (23%), Positives = 116/271 (42%), Gaps = 29/271 (10%)

Query: 24  FAFSVRWSDGSDTFVRRSWDEFRQLKT-LKETFPVEAGLLRRSDRVLPKLLDAPLLGRVG 82
           +   V WS GS   + R + +F  L+  + + FP+E G      R++P L    L  R  
Sbjct: 27  YIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSH 86

Query: 83  RTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEE 142
                + RL  ++ Y + L+     +++   +  FF  +P DL P            P+E
Sbjct: 87  IRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNP------------PKE 134

Query: 143 QPLSR---AAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLV 199
           + + +      + S+  +  +    +  +  Q++ +        + +D++ ++ SGWW V
Sbjct: 135 EHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSE--ISLSVGQVVDIIEKNESGWWFV 192

Query: 200 ENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQ----FCASRAYESSRADELSVPAG 255
              + Q  W PA  LE      G++G     S  P+    +     Y +   DE+++  G
Sbjct: 193 STAEEQ-GWVPATCLE------GQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERG 245

Query: 256 ARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 286
           A V V++ +  GWW  RY  + G  PA  L+
Sbjct: 246 AVVEVIQKNLEGWWKIRYQGKEGWAPASYLK 276



 Score = 36.2 bits (82), Expect = 0.048
 Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 14/99 (14%)

Query: 242 YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL----------RPEGLG 291
           ++++  D +S  AG +V V+E +  GWW  +  D+ G  PA  +          RP  L 
Sbjct: 379 FQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLA 438

Query: 292 AL-LSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRP 329
            L    T  R G+  A E       S+AT P   +P  P
Sbjct: 439 PLPHEVTQLRLGEAAALENN---TGSEATGPSRPLPDAP 474



 Score = 32.7 bits (73), Expect = 0.54
 Identities = 12/36 (33%), Positives = 25/36 (69%), Gaps = 1/36 (2%)

Query: 181 QAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEE 216
           QA   ++V+ ++ SGWW ++ ED++  W PA ++++
Sbjct: 390 QAGLKVEVIEKNLSGWWYIQIEDKE-GWAPATFIDK 424


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 30/101 (29%), Positives = 43/101 (42%), Gaps = 9/101 (8%)

Query: 191  RHPSGWWLVE----NEDRQTAWFPAPYLEEAAPGQGR----EGGPSLGSSGP-QFCASRA 241
            ++P GWW  E     + RQ  WFPA Y++  +PG  +    E   S   +   Q      
Sbjct: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYD 1165

Query: 242  YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPA 282
            Y +   DEL+   G  + VL   D  WW      + GL P+
Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPS 1206



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 32/117 (27%), Positives = 47/117 (40%), Gaps = 21/117 (17%)

Query: 189  LLRHPSGWWLVENEDRQTAWFPAPYLE-----------------EAAPGQGREGGPSLGS 231
            +L     WW  E +  Q  WFP  Y++                 E+     R   P+   
Sbjct: 942  VLEQQDMWWFGEVQG-QKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKP 1000

Query: 232  --SGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 286
              SG +F A   YESS   +L+   G  + V +  D  WW    GD+AG+ P+  +R
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYVR 1056


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 30/101 (29%), Positives = 43/101 (42%), Gaps = 9/101 (8%)

Query: 191  RHPSGWWLVE----NEDRQTAWFPAPYLEEAAPGQGR----EGGPSLGSSGP-QFCASRA 241
            ++P GWW  E     + RQ  WFPA Y++  +PG  +    E   S   +   Q      
Sbjct: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYD 1165

Query: 242  YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPA 282
            Y +   DEL+   G  + VL   D  WW      + GL P+
Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPS 1206



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 32/117 (27%), Positives = 47/117 (40%), Gaps = 21/117 (17%)

Query: 189  LLRHPSGWWLVENEDRQTAWFPAPYLE-----------------EAAPGQGREGGPSLGS 231
            +L     WW  E +  Q  WFP  Y++                 E+     R   P+   
Sbjct: 942  VLEQQDMWWFGEVQG-QKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKP 1000

Query: 232  --SGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 286
              SG +F A   YESS   +L+   G  + V +  D  WW    GD+AG+ P+  +R
Sbjct: 1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYVR 1056


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 30/101 (29%), Positives = 44/101 (43%), Gaps = 10/101 (9%)

Query: 188  VLLRHPSGWWLVE----NEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP--QFCASRA 241
            +L ++ SGWW  E     + RQ  WFPA +++   P   R    +  +  P  Q  A   
Sbjct: 1055 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSER----ATPAFHPVCQVIAMYD 1110

Query: 242  YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPA 282
            Y ++  DELS   G  + V+   D  WW        GL P+
Sbjct: 1111 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPS 1151



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 37/180 (20%), Positives = 70/180 (38%), Gaps = 28/180 (15%)

Query: 154  IHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPY 213
            + +L+AQ+L      C+   +       ++  +  +L     WW  E    +  WFP  Y
Sbjct: 871  VENLKAQAL------CSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-GWFPKSY 923

Query: 214  LEEAAPGQGREGGP-------------SLGSSGPQFCASRAYESSRADELSVPAGARVRV 260
            ++     + +   P             +  S G ++ A   Y S    +L+   G  + V
Sbjct: 924  VKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILV 983

Query: 261  LETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATA 320
             +  D  WW    GDR+G+ P+  ++P+   +        G    +G +   PE +Q T+
Sbjct: 984  TQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESF-------GSASKSGASNKKPEIAQVTS 1035


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 30/101 (29%), Positives = 44/101 (43%), Gaps = 10/101 (9%)

Query: 188  VLLRHPSGWWLVE----NEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP--QFCASRA 241
            +L ++ SGWW  E     + RQ  WFPA +++   P   R    +  +  P  Q  A   
Sbjct: 1082 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSER----ATPAFHPVCQVIAMYD 1137

Query: 242  YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPA 282
            Y ++  DELS   G  + V+   D  WW        GL P+
Sbjct: 1138 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPS 1178



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 37/180 (20%), Positives = 70/180 (38%), Gaps = 28/180 (15%)

Query: 154  IHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPY 213
            + +L+AQ+L      C+   +       ++  +  +L     WW  E    +  WFP  Y
Sbjct: 898  VENLKAQAL------CSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-GWFPKSY 950

Query: 214  LEEAAPGQGREGGP-------------SLGSSGPQFCASRAYESSRADELSVPAGARVRV 260
            ++     + +   P             +  S G ++ A   Y S    +L+   G  + V
Sbjct: 951  VKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILV 1010

Query: 261  LETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATA 320
             +  D  WW    GDR+G+ P+  ++P+   +        G    +G +   PE +Q T+
Sbjct: 1011 TQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESF-------GSASKSGASNKKPEIAQVTS 1062


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 30/101 (29%), Positives = 44/101 (43%), Gaps = 10/101 (9%)

Query: 188  VLLRHPSGWWLVE----NEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP--QFCASRA 241
            +L ++ SGWW  E     + RQ  WFPA +++   P   R    +  +  P  Q  A   
Sbjct: 1082 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSER----ATPAFHPVCQVIAMYD 1137

Query: 242  YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPA 282
            Y ++  DELS   G  + V+   D  WW        GL P+
Sbjct: 1138 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPS 1178



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 37/180 (20%), Positives = 70/180 (38%), Gaps = 28/180 (15%)

Query: 154  IHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPY 213
            + +L+AQ+L      C+   +       ++  +  +L     WW  E    +  WFP  Y
Sbjct: 898  VENLKAQAL------CSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-GWFPKSY 950

Query: 214  LEEAAPGQGREGGP-------------SLGSSGPQFCASRAYESSRADELSVPAGARVRV 260
            ++     + +   P             +  S G ++ A   Y S    +L+   G  + V
Sbjct: 951  VKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILV 1010

Query: 261  LETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATA 320
             +  D  WW    GDR+G+ P+  ++P+   +        G    +G +   PE +Q T+
Sbjct: 1011 TQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESF-------GSASKSGASNKKPEIAQVTS 1062


>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 38/151 (25%), Positives = 54/151 (35%), Gaps = 47/151 (31%)

Query: 178 FQAQAQESLDV-------LLRHPSGWWLVENEDRQTAWFPAPYLE--------------- 215
           + AQ  + LD+       LL     WW V N   +T + P+ Y+E               
Sbjct: 13  YTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNLK 72

Query: 216 ---------------EAAPGQGREGGPSLGSSG---------PQFCASRAYESSRADELS 251
                          +A+P    +       SG         P F    AY + R DELS
Sbjct: 73  DTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAF-VKFAYVAEREDELS 131

Query: 252 VPAGARVRVLETSDRGWWLCRYGDRAGLLPA 282
           +  G+RV V+E    GWW   Y  + G  P+
Sbjct: 132 LVKGSRVTVMEKCSDGWWRGSYNGQIGWFPS 162


>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 38/151 (25%), Positives = 54/151 (35%), Gaps = 47/151 (31%)

Query: 178 FQAQAQESLDV-------LLRHPSGWWLVENEDRQTAWFPAPYLE--------------- 215
           + AQ  + LD+       LL     WW V N   +T + P+ Y+E               
Sbjct: 13  YTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNLK 72

Query: 216 ---------------EAAPGQGREGGPSLGSSG---------PQFCASRAYESSRADELS 251
                          +A+P    +       SG         P F    AY + R DELS
Sbjct: 73  DTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAF-VKFAYVAEREDELS 131

Query: 252 VPAGARVRVLETSDRGWWLCRYGDRAGLLPA 282
           +  G+RV V+E    GWW   Y  + G  P+
Sbjct: 132 LVKGSRVTVMEKCSDGWWRGSYNGQIGWFPS 162


>gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]
          Length = 690

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 17/137 (12%)

Query: 196 WWLVENEDRQTAWFPAPYL---EEAAPGQGREGGPSLGSSGPQFCASR--AYESSRADEL 250
           W    N+  +  + P  YL   + + P   ++     G+    F A    +Y    A+EL
Sbjct: 506 WVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDNPCGAEPTAFLAQALYSYTGQSAEEL 565

Query: 251 SVPAGARVRVLETS----DRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPA 306
           S P GA +R+L  +    D G+W   +G R G+ P++L+       LL   G     DP 
Sbjct: 566 SFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVE-----ELLGPPGPPELSDP- 619

Query: 307 GEARGFPEPSQATAPPP 323
              +  P PS  +  PP
Sbjct: 620 --EQMLPSPSPPSFSPP 634


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 20/102 (19%)

Query: 220 GQGR-EGGP-SLGSSGPQFCASRAYESSRADELSVPAGARVRVLE-----TSDRGWWLCR 272
           G GR EG P + G + P + A   YE S  DEL++  G RV VL      + D GWW  +
Sbjct: 28  GGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQ 87

Query: 273 YGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPE 314
            G + G+ P             S    RGG  P  E   F E
Sbjct: 88  VGGQVGIFP-------------SNYVSRGGGPPPCEVASFQE 116



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 32/106 (30%), Positives = 38/106 (35%), Gaps = 15/106 (14%)

Query: 276 RAGLLPAVLLRPEGLGALLS---GTGFRGGDDPAGEARGFPEPSQATAPP---------- 322
           RA L    LL   GLG  L    G G   G+ P       P P     PP          
Sbjct: 643 RALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKT 702

Query: 323 PTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCVDSVPHPTT 368
           P  P  P+P  +        R A  + PRR+  PRG   S P  T+
Sbjct: 703 PDSPPTPAPLLLDLGIPVGQRSA--KSPRREEEPRGGTVSPPPGTS 746


>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
          Length = 377

 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 35/152 (23%), Positives = 52/152 (34%), Gaps = 40/152 (26%)

Query: 178 FQAQAQESLDV-------LLRHPSGWWLVENEDRQTAWFPAPYLEE-------------- 216
           + AQ ++ LD+       LL     WW V N   +T + P+ Y+E               
Sbjct: 13  YVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLK 72

Query: 217 ------------AAPGQGREGGPSLGSSGPQFCASRA-------YESSRADELSVPAGAR 257
                       + P        S    G +             Y + R DELS+  G +
Sbjct: 73  DTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTK 132

Query: 258 VRVLETSDRGWWLCRYGDRAGLLPAVLLRPEG 289
           V V+E    GWW   Y  + G  P+  +  EG
Sbjct: 133 VIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEG 164



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 29/113 (25%), Positives = 44/113 (38%), Gaps = 23/113 (20%)

Query: 188 VLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFC---------- 237
           V+ +   GWW   + + Q  WFP+ Y+ E         G  +GS   +            
Sbjct: 135 VMEKCSDGWWR-GSYNGQVGWFPSNYVTEEGDS---PLGDHVGSLSEKLAAVVNNLNTGQ 190

Query: 238 ------ASRAYESSRADELSVPAGARVRVLE--TSDRGWWLCR-YGDRAGLLP 281
                 A   + SS  +EL+   G  + V+E   +D  WW CR      GL+P
Sbjct: 191 VLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVP 243


>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
           [Homo sapiens]
          Length = 303

 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 39/175 (22%), Positives = 64/175 (36%), Gaps = 11/175 (6%)

Query: 98  SRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSL 157
           +RR     +     P +  F+    LD    + P  R   P+P    +S  A  L     
Sbjct: 68  NRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY--PSPPMGSVS--APNLPTAED 123

Query: 158 EAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEA 217
             + +R L  F   D  D PF+    E L ++ +    WW   N+D +    P PY+E+ 
Sbjct: 124 NLEYVRTLYDFPGNDAEDLPFKKG--EILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKL 181

Query: 218 APG-----QGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRG 267
                    G     S G   P    ++   ++    +S   GA +  L ++  G
Sbjct: 182 VRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNG 236



 Score = 36.2 bits (82), Expect = 0.048
 Identities = 36/139 (25%), Positives = 55/139 (39%), Gaps = 15/139 (10%)

Query: 203 DRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASRA---YESSRADELSVPAGARVR 259
           D  T   PAP     +P  G    P+L ++       R    +  + A++L    G  + 
Sbjct: 94  DTTTLIEPAP--RYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILV 151

Query: 260 VLETSDRGWWLCRYGD-RAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQA 318
           ++E  +  WW  R  D R G++P   +      +     G R  +     + G PEP+ A
Sbjct: 152 IIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSN-----SYGIPEPAHA 206

Query: 319 TAPPPTVPTRP----SPGA 333
            A P T    P    SPGA
Sbjct: 207 YAQPQTTTPLPAVSGSPGA 225


>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 41/156 (26%), Positives = 62/156 (39%), Gaps = 35/156 (22%)

Query: 166 QPFCTQDTRDRPFQA-----QAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPG 220
           Q +C  +    P QA     QA E ++++     GWWL + ++ Q   FP+ ++E    G
Sbjct: 85  QRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGK-KNGQLGAFPSNFVELLDSG 143

Query: 221 QGREGGPSL-----GSSGPQFCASRAYES----------------------SRADELSVP 253
               G P +     G   P   +S AY+S                         DEL++ 
Sbjct: 144 PPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALR 203

Query: 254 AGARVRVLE--TSDRGWWLCRYGDRAGLLPAVLLRP 287
            G  V+VL   T D+GWW      R G+ P   + P
Sbjct: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLP 239



 Score = 37.0 bits (84), Expect = 0.028
 Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 1/61 (1%)

Query: 223 REGGPSLGSSGPQFC-ASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLP 281
           R G P+      ++C  + +Y   +ADEL + AG  V +++  + GWWL +   + G  P
Sbjct: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133

Query: 282 A 282
           +
Sbjct: 134 S 134



 Score = 30.4 bits (67), Expect = 2.7
 Identities = 20/52 (38%), Positives = 27/52 (51%), Gaps = 3/52 (5%)

Query: 242 YESSRADELSVPAGARVRVLE-TSDRGWWLCRYGDRAGLLPAVLLR--PEGL 290
           Y + + DELS+  G  VR +     RGW    +G R GL P  L++  PE L
Sbjct: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL 60


>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
          Length = 731

 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 19/50 (38%), Positives = 29/50 (58%)

Query: 238 ASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRP 287
           A  ++ +  +D+LS   G R+++LE  D  W   R  DR G+ PAV +RP
Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRP 658


>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
          Length = 767

 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 19/50 (38%), Positives = 29/50 (58%)

Query: 238 ASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRP 287
           A  ++ +  +D+LS   G R+++LE  D  W   R  DR G+ PAV +RP
Sbjct: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRP 694


>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
          Length = 790

 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 19/50 (38%), Positives = 29/50 (58%)

Query: 238 ASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRP 287
           A  ++ +  +D+LS   G R+++LE  D  W   R  DR G+ PAV +RP
Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRP 717


>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
           sapiens]
          Length = 735

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 43/127 (33%), Positives = 54/127 (42%), Gaps = 25/127 (19%)

Query: 210 PAPYLEEAAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWW 269
           P P   E  P Q  EG  + G+ GP      + E+SR    S   GA ++ LE S R W 
Sbjct: 36  PEPSPPEPEP-QAPEGSQA-GAEGPS-----SPEASR----SPARGAYLQSLEPSSRRWV 84

Query: 270 LCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRP 329
           L       G  PA       LG  + GTG     +PAGE    P P +   PP   P  P
Sbjct: 85  L------GGAKPA---EDTSLGPGVPGTG-----EPAGEIWYNPIPEEDPRPPAPEPPGP 130

Query: 330 SPGAIQS 336
            PG+ +S
Sbjct: 131 QPGSAES 137


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
           sapiens]
          Length = 1118

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 9/97 (9%)

Query: 215 EEAAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLE-----TSDRGWW 269
           EEAA   G  G     +  P + A   YE++  DEL++  G  V VL      + D GWW
Sbjct: 37  EEAAAAVG-PGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWW 95

Query: 270 LCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPA 306
             +   R G+ P+  + P    +  S     GG+DP+
Sbjct: 96  TGQLNQRVGIFPSNYVTPR---SAFSSRCQPGGEDPS 129


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 32/106 (30%), Positives = 46/106 (43%), Gaps = 11/106 (10%)

Query: 216 EAAPGQGREGGPSLG-----SSGPQFCASRAYESSRAD--ELSVPAGARVRVLETSDRGW 268
           +A+P   + GG  L      S G   CA   ++    D  EL   AG  ++VLE S++ W
Sbjct: 125 QASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDW 184

Query: 269 WLCRYGDRAGLLPAVLLR----PEGLGALLSGTGFRGGDDPAGEAR 310
           W  R  D+    PA  +R     E L    S T     D+ A ++R
Sbjct: 185 WWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSR 230


>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo
           sapiens]
          Length = 2161

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 13/81 (16%)

Query: 215 EEAAPGQGREGGP--SLGSSGPQ-----------FCASRAYESSRADELSVPAGARVRVL 261
           E  A G G  GGP  SLGS G +           F A ++Y++    E+S+  G +++VL
Sbjct: 525 EGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVL 584

Query: 262 ETSDRGWWLCRYGDRAGLLPA 282
              + G+W  +   R G  P+
Sbjct: 585 SIGEGGFWEGQVKGRVGWFPS 605


>gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens]
          Length = 411

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 21/73 (28%), Positives = 34/73 (46%), Gaps = 2/73 (2%)

Query: 212 PYLEEAAPGQGREGGPSLGSSGPQFCASRAYE--SSRADELSVPAGARVRVLETSDRGWW 269
           P  EE +PGQ           GP +     Y+      ++L++  G R+ +++ S+  WW
Sbjct: 271 PGPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWW 330

Query: 270 LCRYGDRAGLLPA 282
             + GDR G  PA
Sbjct: 331 KGKIGDRVGFFPA 343


>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
          Length = 740

 Score = 39.3 bits (90), Expect = 0.006
 Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 12/86 (13%)

Query: 242 YESSRADELSVPAGARVRVL---ETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTG 298
           YE    DELS P GA +R+L      D G+W   +  R G+ P+VL+  E L A      
Sbjct: 578 YEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLV--EELSA------ 629

Query: 299 FRGGDDP-AGEARGFPEPSQATAPPP 323
              GD P   E +  P P    + PP
Sbjct: 630 SENGDTPWMREIQISPSPKPHASLPP 655


>gi|157266298 anti-Mullerian hormone [Homo sapiens]
          Length = 560

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 62/230 (26%), Positives = 75/230 (32%), Gaps = 39/230 (16%)

Query: 163 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG 222
           R L  F   +T DR     +   L   LR P G  LV     +  W P P L    P  G
Sbjct: 95  RDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPG 154

Query: 223 REGGPSLG------SSGPQFCASRAYESSRADELSVPAGARVRVLETS-DRGWWLCRYGD 275
             G P L         GP+   +RA     A  L      R  VL      G W      
Sbjct: 155 GAGPPELALLVLYPGPGPEVTVTRA-GLPGAQSLCPSRDTRYLVLAVDRPAGAW------ 207

Query: 276 RAGLLPAVLLRPEGLGALLSGTGFRG---GDD--------------PAGEARGFPEPSQA 318
             G   A+ L+P G  + LS    +    GDD              P  E    P   Q 
Sbjct: 208 -RGSGLALTLQPRGEDSRLSTARLQALLFGDDHRCFTRMTPALLLLPRSEPAPLPAHGQL 266

Query: 319 TA-----PPPTVPTRPSPGAIQSRCCTVTR--RALERRPRRQGRPRGCVD 361
                  P P+     SP +      T+TR  RAL   P R   PR  +D
Sbjct: 267 DTVPFPPPRPSAELEESPPSADPFLETLTRLVRALRVPPARASAPRLALD 316


>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 30/118 (25%), Positives = 43/118 (36%), Gaps = 30/118 (25%)

Query: 217 AAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLE-----TSDRGWWLC 271
           +A       G S  +    + A   YE+   DELS+  G  V VL      + D GWW  
Sbjct: 24  SASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAG 83

Query: 272 RYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRP 329
           +   R G+ PA  + P                           P+ + APPP+ P+ P
Sbjct: 84  QVQRRLGIFPANYVAP-------------------------CRPAASPAPPPSRPSSP 116


>gi|23510413 sorting nexin 26 [Homo sapiens]
          Length = 1126

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 15/123 (12%)

Query: 240 RAYESSRADELSVPAGARVRVLE---TSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSG 296
           + Y +   DELS   G  V V++   T DR WW  + G + G  P+  +    L     G
Sbjct: 195 KRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPSECVE---LFTERPG 251

Query: 297 TGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQG-R 355
            G +   D  G   G P P   ++    VP RP     + +   + R  +  RP RQ  R
Sbjct: 252 PGLKA--DADGPPCGIPAPQGISSLTSAVP-RP-----RGKLAGLLRTFMRSRPSRQRLR 303

Query: 356 PRG 358
            RG
Sbjct: 304 QRG 306


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,286,591
Number of Sequences: 37866
Number of extensions: 999720
Number of successful extensions: 6644
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 147
Number of HSP's that attempted gapping in prelim test: 6110
Number of HSP's gapped (non-prelim): 632
length of query: 370
length of database: 18,247,518
effective HSP length: 104
effective length of query: 266
effective length of database: 14,309,454
effective search space: 3806314764
effective search space used: 3806314764
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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