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Search of human proteins with 112382239
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112382239 desmuslin isoform B [Homo sapiens]
(1253 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112382239 desmuslin isoform B [Homo sapiens] 2446 0.0
gi|112382237 desmuslin isoform A [Homo sapiens] 2246 0.0
gi|62414289 vimentin [Homo sapiens] 153 1e-36
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 142 2e-33
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 142 2e-33
gi|21264345 peripherin [Homo sapiens] 142 2e-33
gi|38176300 nestin [Homo sapiens] 135 3e-31
gi|55749932 desmin [Homo sapiens] 132 2e-30
gi|14249342 internexin neuronal intermediate filament protein, a... 130 6e-30
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 130 1e-29
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 127 7e-29
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 113 1e-24
gi|4557701 keratin 17 [Homo sapiens] 102 2e-21
gi|10337581 type I hair keratin 3B [Homo sapiens] 97 7e-20
gi|14917117 keratin 33A [Homo sapiens] 96 3e-19
gi|24430192 keratin 16 [Homo sapiens] 95 5e-19
gi|94538345 keratin 35 [Homo sapiens] 94 6e-19
gi|27436951 lamin B2 [Homo sapiens] 94 8e-19
gi|14917115 keratin 31 [Homo sapiens] 94 1e-18
gi|4504927 keratin 36 [Homo sapiens] 93 1e-18
gi|4504919 keratin 8 [Homo sapiens] 92 3e-18
gi|15431310 keratin 14 [Homo sapiens] 92 4e-18
gi|27436948 lamin A/C isoform 3 [Homo sapiens] 91 9e-18
gi|5031875 lamin A/C isoform 2 [Homo sapiens] 91 9e-18
gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens] 91 9e-18
gi|14917119 keratin 34 [Homo sapiens] 89 2e-17
gi|195972866 keratin 10 [Homo sapiens] 89 2e-17
gi|24430190 keratin 15 [Homo sapiens] 87 8e-17
gi|24234699 keratin 19 [Homo sapiens] 87 1e-16
gi|5031877 lamin B1 [Homo sapiens] 87 1e-16
>gi|112382239 desmuslin isoform B [Homo sapiens]
Length = 1253
Score = 2446 bits (6339), Expect = 0.0
Identities = 1253/1253 (100%), Positives = 1253/1253 (100%)
Query: 1 MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC 60
MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC
Sbjct: 1 MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC 60
Query: 61 AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL 120
AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL
Sbjct: 61 AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL 120
Query: 121 QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL 180
QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL
Sbjct: 121 QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL 180
Query: 181 REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE 240
REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE
Sbjct: 181 REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE 240
Query: 241 ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300
ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV
Sbjct: 241 ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300
Query: 301 KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR 360
KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR
Sbjct: 301 KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR 360
Query: 361 QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS 420
QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS
Sbjct: 361 QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS 420
Query: 421 SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA 480
SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA
Sbjct: 421 SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA 480
Query: 481 AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE 540
AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE
Sbjct: 481 AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE 540
Query: 541 ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV 600
ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV
Sbjct: 541 ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV 600
Query: 601 KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA 660
KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA
Sbjct: 601 KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA 660
Query: 661 DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK 720
DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK
Sbjct: 661 DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK 720
Query: 721 SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP 780
SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP
Sbjct: 721 SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP 780
Query: 781 WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG 840
WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG
Sbjct: 781 WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG 840
Query: 841 GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG 900
GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG
Sbjct: 841 GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG 900
Query: 901 DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL 960
DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL
Sbjct: 901 DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL 960
Query: 961 PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS 1020
PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS
Sbjct: 961 PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS 1020
Query: 1021 KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES 1080
KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES
Sbjct: 1021 KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES 1080
Query: 1081 EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM 1140
EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM
Sbjct: 1081 EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM 1140
Query: 1141 SYEGPTAEVVEMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEG 1200
SYEGPTAEVVEMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEG
Sbjct: 1141 SYEGPTAEVVEMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEG 1200
Query: 1201 DQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF 1253
DQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF
Sbjct: 1201 DQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF 1253
>gi|112382237 desmuslin isoform A [Homo sapiens]
Length = 1565
Score = 2246 bits (5819), Expect = 0.0
Identities = 1151/1152 (99%), Positives = 1152/1152 (100%)
Query: 1 MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC 60
MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC
Sbjct: 1 MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC 60
Query: 61 AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL 120
AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL
Sbjct: 61 AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL 120
Query: 121 QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL 180
QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL
Sbjct: 121 QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL 180
Query: 181 REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE 240
REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE
Sbjct: 181 REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE 240
Query: 241 ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300
ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV
Sbjct: 241 ALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300
Query: 301 KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR 360
KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR
Sbjct: 301 KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR 360
Query: 361 QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS 420
QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS
Sbjct: 361 QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS 420
Query: 421 SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA 480
SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA
Sbjct: 421 SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA 480
Query: 481 AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE 540
AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE
Sbjct: 481 AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE 540
Query: 541 ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV 600
ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV
Sbjct: 541 ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV 600
Query: 601 KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA 660
KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA
Sbjct: 601 KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA 660
Query: 661 DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK 720
DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK
Sbjct: 661 DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK 720
Query: 721 SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP 780
SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP
Sbjct: 721 SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP 780
Query: 781 WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG 840
WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG
Sbjct: 781 WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG 840
Query: 841 GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG 900
GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG
Sbjct: 841 GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG 900
Query: 901 DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL 960
DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL
Sbjct: 901 DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL 960
Query: 961 PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS 1020
PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS
Sbjct: 961 PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS 1020
Query: 1021 KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES 1080
KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES
Sbjct: 1021 KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES 1080
Query: 1081 EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM 1140
EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM
Sbjct: 1081 EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM 1140
Query: 1141 SYEGPTAEVVEM 1152
SYEGPTAEVVE+
Sbjct: 1141 SYEGPTAEVVEV 1152
Score = 223 bits (567), Expect = 1e-57
Identities = 133/222 (59%), Positives = 148/222 (66%), Gaps = 29/222 (13%)
Query: 1032 ESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGESEVAGGASHSSG 1091
+SVV ES P S ++ GAE + R R +I G +E + +S
Sbjct: 1373 QSVVSES------PQEDSAEDTSGAEMTSGVSRSFR------HIRLGPTE-----TETSE 1415
Query: 1092 QRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERMSYEGPTAEVVE 1151
+GPVS T ++ + L D S+ RHI GP E T+ +
Sbjct: 1416 HIAIRGPVSRTFVLAGSADSPELGKLADSSRTLRHIAPGPKE------------TSFTFQ 1463
Query: 1152 MDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQ 1211
MDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQ
Sbjct: 1464 MDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQ 1523
Query: 1212 AMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF 1253
AMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF
Sbjct: 1524 AMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF 1565
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 153 bits (386), Expect = 1e-36
Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 11/314 (3%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCA----EEARS 66
EK ELQELN R +Y+ +VR LE++N +L EL +G +G++R EE R
Sbjct: 103 EKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKG------QGKSRLGDLYEEEMRE 156
Query: 67 LRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGA 126
LR+Q+D+L+ A E ERD L ++ L+ EE R + L + ++++ A A
Sbjct: 157 LRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLA 216
Query: 127 RAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDS 186
R LE + LQ E L HE +++EL+A+ + + P LR+V
Sbjct: 217 RLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAA-LRDVRQQ 275
Query: 187 YALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQ 246
Y + A++ +E + Y+ + +L EA R ++ QA++E+ ++ ++L E L+
Sbjct: 276 YESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKG 335
Query: 247 LRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSL 306
LE + M E + ++A Q I L+DE + MA LR+YQDLL VK L +
Sbjct: 336 TNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDI 395
Query: 307 EVATYRALLEGESN 320
E+ATYR LLEGE +
Sbjct: 396 EIATYRKLLEGEES 409
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 142 bits (359), Expect = 2e-33
Identities = 101/310 (32%), Positives = 153/310 (49%), Gaps = 3/310 (0%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
E+AE+ ELN R Y+ +VR LE++N L EL R +E + E R LR +
Sbjct: 69 ERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQA--ELRELRLR 126
Query: 71 LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
LD+L+ +A E ERD L ++L +++ +E R + L A ++E EA AR L
Sbjct: 127 LDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDL 186
Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
E + L+ E R L HE +VREL+ + A +H P L+E+ Y +
Sbjct: 187 ERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAA-LKEIRTQYEAM 245
Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRAR 250
+ + E + Y + +L +A R E QA+ E ++ ++L + L
Sbjct: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305
Query: 251 LEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVAT 310
LE + E + +A Q + LE+E +L MA L++YQDLL VK L +E+AT
Sbjct: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365
Query: 311 YRALLEGESN 320
YR LLEGE N
Sbjct: 366 YRKLLEGEEN 375
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 142 bits (359), Expect = 2e-33
Identities = 101/310 (32%), Positives = 153/310 (49%), Gaps = 3/310 (0%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
E+AE+ ELN R Y+ +VR LE++N L EL R +E + E R LR +
Sbjct: 69 ERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQA--ELRELRLR 126
Query: 71 LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
LD+L+ +A E ERD L ++L +++ +E R + L A ++E EA AR L
Sbjct: 127 LDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDL 186
Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
E + L+ E R L HE +VREL+ + A +H P L+E+ Y +
Sbjct: 187 ERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAA-LKEIRTQYEAM 245
Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRAR 250
+ + E + Y + +L +A R E QA+ E ++ ++L + L
Sbjct: 246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNES 305
Query: 251 LEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVAT 310
LE + E + +A Q + LE+E +L MA L++YQDLL VK L +E+AT
Sbjct: 306 LERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 365
Query: 311 YRALLEGESN 320
YR LLEGE N
Sbjct: 366 YRKLLEGEEN 375
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 142 bits (358), Expect = 2e-33
Identities = 99/311 (31%), Positives = 156/311 (50%), Gaps = 3/311 (0%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
EK ELQELN R +++ +VR LE++N L EL RG+E A C +E R LR++
Sbjct: 97 EKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEP--ARADQLCQQELRELRRE 154
Query: 71 LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
L+ L + ERD L +L L++ EE R + L ++++ +A +R L
Sbjct: 155 LELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLEL 214
Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMH-FRARATGPAAPPPRLREVHDSYAL 189
E + L E L HE ++R+L+ S + AT LR++ Y
Sbjct: 215 ERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYES 274
Query: 190 LVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRA 249
+ A++ +E + Y+ + +L +A R E+ QA++E ++ ++L E GL
Sbjct: 275 IAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNE 334
Query: 250 RLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVA 309
L L + E++ ++A Q LE+E L MA LR+YQ+LL VK L +E+A
Sbjct: 335 ALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIA 394
Query: 310 TYRALLEGESN 320
TYR LLEGE +
Sbjct: 395 TYRKLLEGEES 405
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 135 bits (339), Expect = 3e-31
Identities = 106/312 (33%), Positives = 152/312 (48%), Gaps = 6/312 (1%)
Query: 9 GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLR 68
G E ++ ELN RL Y+ RV+ LE +N LL EL G R + +A +E +LR
Sbjct: 6 GEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSAD-TSWRAHADDELAALR 64
Query: 69 QQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARA 128
+D+ AE RD L EL + + R AR R E+ +R ++ ARA
Sbjct: 65 ALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARA 124
Query: 129 ALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYA 188
L + + L+ E L AHE + L A+AA A GP AP P + E+ A
Sbjct: 125 WLSSQVAELERELEALRVAHEEERVGLNAQAACAP-RCPAPPRGPPAPAPEVEEL----A 179
Query: 189 LLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLR 248
+ E+WR V+ Y++ V +E +L + +E +A + R E + L+ E GL + R
Sbjct: 180 RRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERR 239
Query: 249 ARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEV 308
A LE L +E E+ Q ++ LE EK L +A L Q L +K LSLEV
Sbjct: 240 AALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEV 299
Query: 309 ATYRALLEGESN 320
ATYR LLE E++
Sbjct: 300 ATYRTLLEAENS 311
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 132 bits (332), Expect = 2e-30
Identities = 97/310 (31%), Positives = 153/310 (49%), Gaps = 3/310 (0%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
EK ELQELN R +Y+ +VR LE++N L E+ +GRE EE R LR+Q
Sbjct: 108 EKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREP--TRVAELYEEELRELRRQ 165
Query: 71 LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
++ L+ A + ERD L +L+ L+ EE + + L A + ++ A AR L
Sbjct: 166 VEVLTNQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDL 225
Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
E + L E L HE ++REL+A+ + + P LR++ Y +
Sbjct: 226 ERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAA-LRDIRAQYETI 284
Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRAR 250
A++ E + Y+ +V +L +A + ++ QA++E + ++ E L+
Sbjct: 285 AAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDS 344
Query: 251 LEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVAT 310
L + + + + +A Q I LE+E L MA LR+YQDLL VK L +E+AT
Sbjct: 345 LMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIAT 404
Query: 311 YRALLEGESN 320
YR LLEGE +
Sbjct: 405 YRKLLEGEES 414
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 130 bits (328), Expect = 6e-30
Identities = 101/310 (32%), Positives = 143/310 (46%), Gaps = 2/310 (0%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
EK +LQ LN R ++ +V +LE +N LE EL R R + E R LR Q
Sbjct: 94 EKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQ 153
Query: 71 LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
L+E S A + A ERD L E++ L+ EE R + L AQQR++ A AR L
Sbjct: 154 LEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDL 213
Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPP--PRLREVHDSYA 188
E + L E + H+ +V EL A + + A P LRE+ Y
Sbjct: 214 EKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYE 273
Query: 189 LLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLR 248
L A++ + + Y+ + L E R E+ + EE ++ +A E GL
Sbjct: 274 SLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGAN 333
Query: 249 ARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEV 308
LE +L + E + + Q I LE++ MA LR+YQDLL VK L +E+
Sbjct: 334 ESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEI 393
Query: 309 ATYRALLEGE 318
A YR LLEGE
Sbjct: 394 AAYRKLLEGE 403
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 130 bits (326), Expect = 1e-29
Identities = 94/311 (30%), Positives = 150/311 (48%), Gaps = 7/311 (2%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
EKA+LQ+LN R ++ RV ELE++N +LE EL R + + +A +E R LR
Sbjct: 90 EKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLA 149
Query: 71 LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
++ + +GER+ L LR LQ EE +R + L ++ EA ARA L
Sbjct: 150 AEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAEL 209
Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
E + L E L HE ++ EL+A+ + T P L+++ Y L
Sbjct: 210 EKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDL-SAALKDIRAQYEKL 268
Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRA- 249
A++ + + ++ L E+ + ++ A++E ++ L+ + L +E R
Sbjct: 269 AAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEV---SESRRLLKAKTLEIEACRGM 325
Query: 250 --RLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLE 307
LE L + ++ Q I+ LE+E T MA +L++YQDLL VK L +E
Sbjct: 326 NEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIE 385
Query: 308 VATYRALLEGE 318
+A YR LLEGE
Sbjct: 386 IAAYRKLLEGE 396
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 127 bits (319), Expect = 7e-29
Identities = 210/894 (23%), Positives = 340/894 (38%), Gaps = 86/894 (9%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGRE-GLWAEGQARCAEEARSLRQ 69
EK +LQ LN R Y+ +VR+LE N LE E R ++ G A G+ E R +R
Sbjct: 97 EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELY-EREVREMRG 155
Query: 70 QLDELSWATALAEGERDALRRELREL-QRLDAEERAARGRLDAELGAQQRELQEALGARA 128
+ L A E++ L ++ + QRLD E R R +A A R QEA AR
Sbjct: 156 AVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQ-REEAEAAARALARFAQEAEAARV 214
Query: 129 ALEALLGRLQAERRGLDAAHERDVRELRAR-----AASLTMHFRARATGPAAPPPRLREV 183
L+ LQ E L H+ +V EL + AA M R LRE+
Sbjct: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
Query: 184 ------HDSYALLVAESW-RETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEA 236
H + L +E W R + + + +A+R QE + + + E EA
Sbjct: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
Query: 237 LRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQD 296
L+ LE+ R+ LED + Q I L+ E MA LR+YQD
Sbjct: 335 LKSTKDSLERQRSELED-------RHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQD 387
Query: 297 LLQVKTGLSLEVATYRALLEGES-----NPEIVIWAEHVENMPS---EFRNKSYHYTDSL 348
LL VK L +E+A YR LLEGE P E + +PS + KS +
Sbjct: 388 LLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVV 447
Query: 349 LQRENERNLFSRQKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSAT 408
+ E E + Q + + + GG+ G + S
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTE--EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPP 505
Query: 409 TQQENSYGKAVSSQTNVRTFSPTYGLLRNTE-----AQVKTFPDRPKAGDTREVPVYIGE 463
++ S K S SP E A+VK+ P++ K+ E
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKS-PEKAKSPAKEEAKSPPEA 564
Query: 464 DSTIARESYRDRRDKVAAGASESTRSNERTVILGKKTE--VKATREQERNRPETIRTKPE 521
S E+ K A + ++ K E +E+ ++ E E
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 522 EKMFDSKEKASEERNLRWEELTKLDKEARQRESQQMK--EKAKEKDSPKEKSVREREVPI 579
E ++ K+ E+ +E K ++A+ E ++ K EKAK + KS + + P+
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684
Query: 580 SLEVSQDRRAE-------VSPKGLQTPVKD-------AGGGTGREAEARELRFRLGTSDA 625
E +A+ SP+ ++PVK+ A EA+ E + + +
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE-KAKSPVKEE 743
Query: 626 TGSLQGDSMTETVAENIVTSILKQFTQSPETEASADSFPDTKVTYVDRKELPGERKTKTE 685
S + E V S + E + AD FP+ + V ++E+ K K+
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV-KEEVKSPEKAKSP 802
Query: 686 IVVESKLTE-DVDVSDEAGLDYLLSKDIKEVGLK--GKSAEQMIGDIINLGLKGREGR-- 740
+ ++K E ++ +E + +EV +K K AE+ + ++ +
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862
Query: 741 ------AKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVED---------VSPGPWGLVK 785
A VE +EP + EKP+E V K EE ED +P + +
Sbjct: 863 EAPKKEAPKPKVEEKKEP----AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918
Query: 786 EEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHP 839
+ + +++V + K+P + E E D++ E++ P+E P
Sbjct: 919 DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA---KKPEEKP 969
Score = 36.6 bits (83), Expect = 0.15
Identities = 34/139 (24%), Positives = 62/139 (44%), Gaps = 4/139 (2%)
Query: 436 RNTEAQVKTFPDRPKAGDTREVPVYIGEDSTI-ARESYRDRRDKVAAGASESTRSNERTV 494
+ EA K P +PK + +E V ++S + A++ + + KV E+ E
Sbjct: 860 KKEEAPKKEAP-KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918
Query: 495 ILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEK--ASEERNLRWEELTKLDKEARQR 552
K + + +++ + +KP EK + EK EE+ + EE K + +A++
Sbjct: 919 DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978
Query: 553 ESQQMKEKAKEKDSPKEKS 571
+ KE +K K EKS
Sbjct: 979 DKTLSKEPSKPKAEKAEKS 997
Score = 35.0 bits (79), Expect = 0.45
Identities = 112/535 (20%), Positives = 206/535 (38%), Gaps = 66/535 (12%)
Query: 544 KLDKEARQRESQQMKEKAKEKDSPKEKSVR----EREVPISLEVSQDRRAEVSPKG-LQT 598
+LD EARQRE + +A + + + ++ R ++ + E RR G L
Sbjct: 184 RLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLG 243
Query: 599 PVKDAGGGTGR-EAEARELRFRLGTS---DATGSLQGDSMTETV-AENIVTSILKQFTQS 653
++ +G + +AE R+ TS + L+G ++ T+ +E L + +++
Sbjct: 244 QIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEA 303
Query: 654 PETEASADSFPDTKVTYVDRK------ELPGERKTKTEIVVESKLTEDVDVSDEAGLDYL 707
+ A ++T R+ EL + TK + + ED +D A
Sbjct: 304 AKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEA 363
Query: 708 LSK-DIKEVGLKGKSAEQM--IGDIINLGLKGREGRAKVVNVEIVE-----EPVSYVSGE 759
+ + D + K + A Q+ D++N+ + +++EI E G
Sbjct: 364 IQQLDAELRNTKWEMAAQLREYQDLLNVKM--------ALDIEIAAYRKLLEGEECRIGF 415
Query: 760 KPEEFSVPFKVEEVEDVSPGPWGLVKEEEGY-----GESDVTFSVNQHRRTKQPQENTTH 814
P FS+P + ++ VS VK EE E + Q T+ +E T
Sbjct: 416 GPIPFSLPEGLPKIPSVSTHI--KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTE- 472
Query: 815 VEEVTEAGDSEGEQSYFVSTPDEHPGGHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTR 874
EE EA + EG++ +E GG + EE ++ + + + +
Sbjct: 473 -EEEKEAKEEEGKEEE-GGEEEEAEGGEEETKSP-----PAEEAASPEKEAKSPVKEEAK 525
Query: 875 RRTQKDGAVGEKVVKPLDVPAPSLEGDLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFH 934
+ E+ P +V +P + + KE+A+S P ++E K P E
Sbjct: 526 SPAEAKSPEKEEAKSPAEVKSP----EKAKSPAKEEAKSPPEAKSPE--KEEAKSPAEVK 579
Query: 935 TSMKGISSKEPRQQLVEVIGQLEETLPERMREELSALTREGQGGPGSVSVDVKKVQGAGG 994
+ K +K P ++ E E PE+ + + +E P VK + A
Sbjct: 580 SPEK---AKSPAKE--EAKSPAEAKSPEKAKSPV----KEEAKSPAEAKSPVK--EEAKS 628
Query: 995 SSVTLVAEVNVSQTVDADRLDLEELS--KDEASEMEKAVESVVRESLSRQRSPAP 1047
+ E S T + + + S K+EA EKA V E+ S +++ +P
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683
Score = 33.1 bits (74), Expect = 1.7
Identities = 41/180 (22%), Positives = 76/180 (42%), Gaps = 25/180 (13%)
Query: 447 DRPKAGDTREVPVYIGEDSTIARESYRDRRD-------KVAAGASESTRSNERTVILGKK 499
++P+ +E P E+ A +++D K A + E V K+
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
Query: 500 TEVKATREQ----------ERNRPETIRTK----PEEKMFDSKEKASEERNLRWEELTKL 545
++V+A +E+ E+ P + K P+EK + +K ++ +
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT-EVAKKEPDDAKAKEPSKPAE 946
Query: 546 DKEARQRESQQMKEKAKE-KDSPK-EKSVREREVPISLEVSQDRRAEVSPKGLQTPVKDA 603
KEA + +EKAK+ ++ PK E +E + +S E S+ +AE + K T KD+
Sbjct: 947 KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP-KAEKAEKSSSTDQKDS 1005
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 113 bits (282), Expect = 1e-24
Identities = 87/318 (27%), Positives = 151/318 (47%), Gaps = 6/318 (1%)
Query: 4 WRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEE 63
++L EK +LQ LN R Y+ +V LE++N +E E++ R ++ A+ +E
Sbjct: 94 YKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQE 153
Query: 64 ARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEA 123
R LR L+ ++ A + + D L ++ L+ EE R +A + A +++++EA
Sbjct: 154 IRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEA 213
Query: 124 LGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREV 183
+ L+ + LQ E L + HE +V +L A+ + + + L+E+
Sbjct: 214 SLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEI 273
Query: 184 HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALG 243
++ + + ++ +L EA + +E+ A+EE A+ L+ +++
Sbjct: 274 RSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEE---IAEYRRQLQSKSIE 330
Query: 244 LEQLRA---RLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQV 300
LE +R LE L + E + Q I LE+E MA LR+YQDLL V
Sbjct: 331 LESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNV 390
Query: 301 KTGLSLEVATYRALLEGE 318
K L +E+A YR LLEGE
Sbjct: 391 KMALDIEIAAYRKLLEGE 408
Score = 52.4 bits (124), Expect = 3e-06
Identities = 153/756 (20%), Positives = 276/756 (36%), Gaps = 83/756 (10%)
Query: 202 YEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRARLEDALLRMR-- 259
Y+ E+REL L + Q + ++ ++ L+ +LR E A+ +R
Sbjct: 150 YDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKD 209
Query: 260 -EEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQ-----------VKTGLSLE 307
EE + E + + L+DE A L + + D +Q +KT +S
Sbjct: 210 IEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTA 269
Query: 308 VATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSRQKAPLAS 367
+ R+ LE S+ + E + ++ + +++ + E + RQ
Sbjct: 270 LKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQ------ 323
Query: 368 FNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVSSQTNVRT 427
S ++ G + S + R S Y + + G ++R
Sbjct: 324 LQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLRE 383
Query: 428 FSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVAAGASEST 487
+ + + ++ + + +TR + G +I Y R + +
Sbjct: 384 YQDLLNVKMALDIEIAAYRKLLEGEETR-FSTFAG---SITGPLYTHRPPITISSKIQKP 439
Query: 488 RSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWEELTKLDK 547
K E + Q + E I E K+ D K + E EEL K
Sbjct: 440 -----------KVEAPKLKVQHKFVEEIIE---ETKVEDEKSEMEEALTAITEELAVSMK 485
Query: 548 EARQRESQQMKEKAKEKDSPKEKSVREREVPISL---EVSQDRRAEVSPKGLQTPVKDAG 604
E E ++ E+ +E+ +E+ V ++ P+ EV ++ + +G + ++
Sbjct: 486 E----EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 541
Query: 605 GGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSI---LKQFTQSPETEASAD 661
G +AE + G+S+ Q + TE AE K +S E +
Sbjct: 542 GAKSDQAEEGGSE-KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE 600
Query: 662 SFPDTKVTYVDR-----KELPGERKTKTEI---VVESKLTEDVDVS--DEAGLDYLLSKD 711
D KV ++ + P E K K+ + VE K V S +E G +
Sbjct: 601 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP 660
Query: 712 IKEVG----LKGKSAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVP 767
++E G K E+ + ++ + +A+V E EE V E P+E V
Sbjct: 661 VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK-EAPKEEKVE 719
Query: 768 FKVEEVEDV--SPGPWGLVKEEEGYGESDVTFSVNQH--RRTKQPQENTTHVEEVTEAGD 823
K E+ +DV VKEE +T SV H + TK+ + +E +AG
Sbjct: 720 KKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGG 779
Query: 824 SEGEQSYFVSTPDEHPGGHDRDD----GSVYGQIHIEEESTIRYSWQDE---IVQGTRRR 876
G + D+ G ++D G V G+ +E+E+ + S ++E +V
Sbjct: 780 EGGSEE---EGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDL 836
Query: 877 TQKDGAVG-----EKVVKPLDVPAPSLEGDLGSTHW 907
+ D G EKVV V + EG G+T +
Sbjct: 837 SPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKY 872
Score = 40.0 bits (92), Expect = 0.014
Identities = 56/242 (23%), Positives = 97/242 (40%), Gaps = 35/242 (14%)
Query: 62 EEARSLRQQLDELSWATALAEGERDALRRELREL---------------QRLDAEERAAR 106
EE R+QL S G +++L R+L ++ Q+L+ E R +
Sbjct: 315 EEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTK 374
Query: 107 GRLDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMH- 165
E+ RE Q+ L + AL+ + A R+ L+ R + L H
Sbjct: 375 W----EMARHLREYQDLLNVKMALDI---EIAAYRKLLEGEETRFSTFAGSITGPLYTHR 427
Query: 166 ----FRARATGPAAPPPRLREVHDSYALLVAESWRETVQLYEDEVRELEEALRR-GQESR 220
++ P P+L+ H ++ E+ EDE E+EEAL +E
Sbjct: 428 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEET------KVEDEKSEMEEALTAITEELA 481
Query: 221 LQAEEETRLCAQE-AEALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDE 279
+ +EE + A+E E E + ++ ++ ++EE G + EE + + EDE
Sbjct: 482 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 541
Query: 280 KA 281
A
Sbjct: 542 GA 543
>gi|4557701 keratin 17 [Homo sapiens]
Length = 432
Score = 102 bits (254), Expect = 2e-21
Identities = 89/317 (28%), Positives = 143/317 (45%), Gaps = 8/317 (2%)
Query: 6 LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQAR-CAEEA 64
L G EKA +Q LN RL Y+ +VR LE N LE ++R R+ A G AR ++
Sbjct: 79 LLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQ---APGPARDYSQYY 135
Query: 65 RSLRQQLDELSWATALAEG---ERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQ 121
R++ + +++ AT + D R + + E+A R ++A++ +R L
Sbjct: 136 RTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLD 195
Query: 122 EALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLR 181
E ARA LE + L+ E L HE ++ LR + ++ A L
Sbjct: 196 ELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGG-EINVEMDAAPGVDLSRILN 254
Query: 182 EVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREA 241
E+ D Y + ++ ++ + + EL + E + E + +AL E
Sbjct: 255 EMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIEL 314
Query: 242 LGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVK 301
++A LE L Y +Q + Q +I +E++ A L M ++Y+ LL VK
Sbjct: 315 QSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVK 374
Query: 302 TGLSLEVATYRALLEGE 318
T L E+ATYR LLEGE
Sbjct: 375 TRLEQEIATYRRLLEGE 391
>gi|10337581 type I hair keratin 3B [Homo sapiens]
Length = 404
Score = 97.4 bits (241), Expect = 7e-20
Identities = 89/323 (27%), Positives = 141/323 (43%), Gaps = 15/323 (4%)
Query: 9 GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR-RGREGLWAEGQARCAEEARSL 67
G EK +Q LN RL Y+ +VR+LER+N LE +R R + +E L + L
Sbjct: 54 GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEEL 113
Query: 68 RQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGAR 127
+Q++ A + D + + + E++ R +++++ + +R L E R
Sbjct: 114 QQKILCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCR 173
Query: 128 AALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREV---- 183
+ LEA + L+ E L HE++V LR + R AAP L +V
Sbjct: 174 SDLEAQMESLKEELLSLKQNHEQEVNTLRCQLGD-----RLNVEVDAAPAVDLNQVLNET 228
Query: 184 HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALG 243
+ Y LV + RE Q + + EL + + E + E + AL E
Sbjct: 229 RNQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288
Query: 244 LEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTG 303
LR LE+ L Y Q + Q +I +E + A + + ++YQ LL V+
Sbjct: 289 QHNLRYSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348
Query: 304 LSLEVATYRALLEGE-----SNP 321
L E+ TYR+LLE E SNP
Sbjct: 349 LECEINTYRSLLESEDCKLPSNP 371
>gi|14917117 keratin 33A [Homo sapiens]
Length = 404
Score = 95.5 bits (236), Expect = 3e-19
Identities = 90/323 (27%), Positives = 139/323 (43%), Gaps = 15/323 (4%)
Query: 9 GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR-RGREGLWAEGQARCAEEARSL 67
G EK +Q LN RL Y+ +VR+LER+N LE +R R + +E L + L
Sbjct: 54 GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCASYQSYFKTIEEL 113
Query: 68 RQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGAR 127
+Q++ A + D + + + E + R +++++ +R L E R
Sbjct: 114 QQKILCSKSENARLVVQIDNAKLASDDFRTKYETELSLRQLVESDINGLRRILDELTLCR 173
Query: 128 AALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREV---- 183
+ LEA + L+ E L HE++V LR + R AAP L +V
Sbjct: 174 SDLEAQVESLKEELLCLKQNHEQEVNTLRCQLGD-----RLNVEVDAAPTVDLNQVLNET 228
Query: 184 HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALG 243
Y LV + RE Q + + EL + + E + E + AL E
Sbjct: 229 RSQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288
Query: 244 LEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTG 303
LR LE+ L Y Q + QR+I +E + A + + ++YQ LL V+
Sbjct: 289 QHNLRDSLENTLTESEARYSSQLSQVQRLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348
Query: 304 LSLEVATYRALLEGE-----SNP 321
L E+ TYR+LLE E SNP
Sbjct: 349 LECEINTYRSLLESEDCKLPSNP 371
>gi|24430192 keratin 16 [Homo sapiens]
Length = 473
Score = 94.7 bits (234), Expect = 5e-19
Identities = 84/314 (26%), Positives = 137/314 (43%), Gaps = 2/314 (0%)
Query: 6 LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREG-LWAEGQARCAEEA 64
L G EK +Q LN RL Y+ +VR LE N LE ++R R+ + + +
Sbjct: 112 LLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTI 171
Query: 65 RSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEAL 124
LR ++ + A + D R + + E A R ++A++ +R L E
Sbjct: 172 EDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELT 231
Query: 125 GARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVH 184
AR LE + L+ E L HE ++ LR + ++ A L E+
Sbjct: 232 LARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGG-DVNVEMDAAPGVDLSRILNEMR 290
Query: 185 DSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGL 244
D Y + ++ R+ + + EL + + E + E + + L E
Sbjct: 291 DQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQ 350
Query: 245 EQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGL 304
++A LE++L + Y +Q + Q +I +E++ A L M ++YQ LL VKT L
Sbjct: 351 LSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRL 410
Query: 305 SLEVATYRALLEGE 318
E+ATYR LLEGE
Sbjct: 411 EQEIATYRRLLEGE 424
>gi|94538345 keratin 35 [Homo sapiens]
Length = 455
Score = 94.4 bits (233), Expect = 6e-19
Identities = 88/326 (26%), Positives = 140/326 (42%), Gaps = 26/326 (7%)
Query: 8 TGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQAR-CAEEARS 66
TG EK +Q LN RL Y+ +VR+LE+EN LE +R W E Q + +S
Sbjct: 94 TGNEKETMQSLNDRLAGYLEKVRQLEQENASLESRIRE-------WCEQQVPYMCPDYQS 146
Query: 67 LRQQLDELSWATALAEGERDALRRELRELQRLDAE--------ERAARGRLDAELGAQQR 118
+ ++EL T ++ E L E+ + +L A+ E + R +++++ +R
Sbjct: 147 YFRTIEELQKKTLCSKAENARLVVEI-DNAKLAADDFRTKYETEVSLRQLVESDINGLRR 205
Query: 119 ELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPP 178
L + ++ LEA + L+ E L HE +V LR + R AAPP
Sbjct: 206 ILDDLTLCKSDLEAQVESLKEELLCLKKNHEEEVNSLRCQLGD-----RLNVEVDAAPPV 260
Query: 179 RLREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEA 234
L V + Y LV + R+ + + EL + + E + E +
Sbjct: 261 DLNRVLEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTV 320
Query: 235 EALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDY 294
AL E +R LE L Y Q + Q +I +E + A + + ++Y
Sbjct: 321 NALEIELQAQHSMRDALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEY 380
Query: 295 QDLLQVKTGLSLEVATYRALLEGESN 320
Q LL V+ L E+ TYR LLE E +
Sbjct: 381 QVLLDVRARLECEINTYRGLLESEDS 406
>gi|27436951 lamin B2 [Homo sapiens]
Length = 600
Score = 94.0 bits (232), Expect = 8e-19
Identities = 94/362 (25%), Positives = 143/362 (39%), Gaps = 51/362 (14%)
Query: 5 RLQTGPEKAELQELNARLYDYVCRVRELEREN----------------------LLLEEE 42
RL EK EL+ELN RL Y+ RVR LE EN L E E
Sbjct: 20 RLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESE 79
Query: 43 LRGRRGREGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLD--- 99
L R A +AR E LR +LDE++ + EGE + +++L+ L
Sbjct: 80 LADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRS 139
Query: 100 ------------------AEERAARGRLDAELGAQQRELQEALGARAALEALLGRLQAER 141
AE RA + + +++L++ R LE LQ E
Sbjct: 140 EVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEEL 199
Query: 142 RGLDAAHERDVRELRARAASLTMHFRARATGP-----AAPPPRLREVHDSYALLVAESWR 196
+ E +VRE R R + + A LR HD L
Sbjct: 200 DFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
Query: 197 ETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRARLEDALL 256
+T Q D + + + ++ A EE + E+L + GL++ + ED +
Sbjct: 260 QTYQAKLDSAKLSSD---QNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIR 316
Query: 257 RMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLE 316
+ E + ++ ++++D E E + M L +YQ+LL VK L +E+ YR LLE
Sbjct: 317 ELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLE 376
Query: 317 GE 318
GE
Sbjct: 377 GE 378
>gi|14917115 keratin 31 [Homo sapiens]
Length = 416
Score = 93.6 bits (231), Expect = 1e-18
Identities = 88/323 (27%), Positives = 138/323 (42%), Gaps = 15/323 (4%)
Query: 9 GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR-RGREGLWAEGQARCAEEARSL 67
G EK +Q LN RL Y+ +VR+LER+N LE +R R + +E L + L
Sbjct: 54 GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEEL 113
Query: 68 RQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGAR 127
+Q++ A + D + + + E + R +++++ +R L E +
Sbjct: 114 QQKILCTKSENARLVVQIDNAKLAADDFRTKYQTELSLRQLVESDINGLRRILDELTLCK 173
Query: 128 AALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLR----EV 183
+ LEA + L+ E L + HE++V LR + R AAP L E
Sbjct: 174 SDLEAQVESLKEELLCLKSNHEQEVNTLRCQLGD-----RLNVEVDAAPTVDLNRVLNET 228
Query: 184 HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALG 243
Y LV + RE Q + + EL + + E + E + AL E
Sbjct: 229 RSQYEALVETNRREVEQWFTTQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQA 288
Query: 244 LEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTG 303
LR LE+ L Y Q + Q +I +E + A + + ++YQ LL V+
Sbjct: 289 QHNLRDSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRAR 348
Query: 304 LSLEVATYRALLEGE-----SNP 321
L E+ TYR+LLE E SNP
Sbjct: 349 LECEINTYRSLLESEDCNLPSNP 371
>gi|4504927 keratin 36 [Homo sapiens]
Length = 467
Score = 93.2 bits (230), Expect = 1e-18
Identities = 91/330 (27%), Positives = 145/330 (43%), Gaps = 40/330 (12%)
Query: 9 GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQAR-CAEEARSL 67
G EK +Q LN RL +Y+ +VR+LEREN LE ++ W E Q + +S
Sbjct: 91 GSEKETMQFLNDRLANYLEKVRQLERENAELESRIQE-------WYEFQIPYICPDYQSY 143
Query: 68 RQQLDELSWATALAEGERDALRRELRELQRLDAE--------ERAARGRLDAELGAQQRE 119
+ +++ L + E L ++ + +L A+ E + R ++A++ +R
Sbjct: 144 FKTIEDFQQKILLTKSENARLVLQI-DNAKLAADDFRTKYETELSLRQLVEADINGLRRI 202
Query: 120 LQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPR 179
L E +A LEA + L+ E L HE +V LR + R AAPP
Sbjct: 203 LDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGD-----RLNVEVDAAPPVD 257
Query: 180 LREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAE 235
L ++ + Y LV + R+ + + EL + + + + E+ + C E
Sbjct: 258 LNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQV-------VSSSEQLQCCQTEII 310
Query: 236 ALRREALGLE-------QLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMA 288
LRR LE +R LE L Y Q + Q +I +E + + + +
Sbjct: 311 ELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLE 370
Query: 289 DWLRDYQDLLQVKTGLSLEVATYRALLEGE 318
++YQ LL VK L E+ATYR LLEGE
Sbjct: 371 RQNQEYQVLLDVKARLEGEIATYRHLLEGE 400
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 92.0 bits (227), Expect = 3e-18
Identities = 84/379 (22%), Positives = 162/379 (42%), Gaps = 11/379 (2%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQ 70
EK +++ LN + ++ +VR LE++N +LE + + ++ + +LR+Q
Sbjct: 91 EKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQ 150
Query: 71 LDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAAL 130
L+ L E E ++ + + + +E R ++ E ++++ EA + L
Sbjct: 151 LETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVEL 210
Query: 131 EALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALL 190
E+ L L E L +E ++REL+++ + ++ + + EV Y +
Sbjct: 211 ESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDI 270
Query: 191 VAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRAR 250
S E +Y+ + EL+ + + + + E + L+ E GL+ RA
Sbjct: 271 ANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRAS 330
Query: 251 LEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVAT 310
LE A+ + + ++ + LE MA LR+YQ+L+ VK L +E+AT
Sbjct: 331 LEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIAT 390
Query: 311 YRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSRQKAPLASFNH 370
YR LLEGE + + S +N S H + + + +P S++
Sbjct: 391 YRKLLEGEES-----------RLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSL 439
Query: 371 SSALYSNLSGHRGSQTGTS 389
S+ S S+T +S
Sbjct: 440 GSSFGSGAGSSSFSRTSSS 458
>gi|15431310 keratin 14 [Homo sapiens]
Length = 472
Score = 91.7 bits (226), Expect = 4e-18
Identities = 82/314 (26%), Positives = 137/314 (43%), Gaps = 2/314 (0%)
Query: 6 LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREG-LWAEGQARCAEEA 64
L G EK +Q LN RL Y+ +VR LE N LE ++R R+ + + +
Sbjct: 110 LLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTI 169
Query: 65 RSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEAL 124
LR ++ + A + D R + + E R ++A++ +R L E
Sbjct: 170 EDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELT 229
Query: 125 GARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVH 184
ARA LE + L+ E L HE ++ LR + ++ A L E+
Sbjct: 230 LARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGG-DVNVEMDAAPGVDLSRILNEMR 288
Query: 185 DSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGL 244
D Y + ++ ++ + + + EL + E + E + + L E
Sbjct: 289 DQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQ 348
Query: 245 EQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGL 304
++A LE++L + Y +Q + Q +I +E++ A L M ++Y+ LL VKT L
Sbjct: 349 LSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRL 408
Query: 305 SLEVATYRALLEGE 318
E+ATYR LLEGE
Sbjct: 409 EQEIATYRRLLEGE 422
>gi|27436948 lamin A/C isoform 3 [Homo sapiens]
Length = 634
Score = 90.5 bits (223), Expect = 9e-18
Identities = 94/355 (26%), Positives = 154/355 (43%), Gaps = 49/355 (13%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLL----------------------EEELRGRRG 48
EK +LQELN RL Y+ RVR LE EN L E EL R
Sbjct: 31 EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90
Query: 49 REGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGR 108
A+ +AR E +R++ EL EG+ A + L++L+ L + AA
Sbjct: 91 TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150
Query: 109 LDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRA 168
+E + EL + G A LEA LG +A+++ D R E R + + F+
Sbjct: 151 ALSEKRTLEGELHDLRGQVAKLEAALG--EAKKQLQDEMLRRVDAENRLQTMKEELDFQK 208
Query: 169 RATGPAAPPP------RLREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQE 218
RL E+ + + +A++ +E +ED+V + ++ L +
Sbjct: 209 NIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYS 268
Query: 219 SRLQ-----AEEETRLCAQEAEALRREALGLEQLRARL---------EDALLR-MREEYG 263
++L AE + L E L++ + ++ L A+L ++A LR + +
Sbjct: 269 AKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328
Query: 264 IQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGE 318
+ + +R++ E E A + M L +YQ+LL +K L +E+ YR LLEGE
Sbjct: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGE 383
>gi|5031875 lamin A/C isoform 2 [Homo sapiens]
Length = 572
Score = 90.5 bits (223), Expect = 9e-18
Identities = 94/355 (26%), Positives = 154/355 (43%), Gaps = 49/355 (13%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLL----------------------EEELRGRRG 48
EK +LQELN RL Y+ RVR LE EN L E EL R
Sbjct: 31 EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90
Query: 49 REGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGR 108
A+ +AR E +R++ EL EG+ A + L++L+ L + AA
Sbjct: 91 TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150
Query: 109 LDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRA 168
+E + EL + G A LEA LG +A+++ D R E R + + F+
Sbjct: 151 ALSEKRTLEGELHDLRGQVAKLEAALG--EAKKQLQDEMLRRVDAENRLQTMKEELDFQK 208
Query: 169 RATGPAAPPP------RLREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQE 218
RL E+ + + +A++ +E +ED+V + ++ L +
Sbjct: 209 NIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYS 268
Query: 219 SRLQ-----AEEETRLCAQEAEALRREALGLEQLRARL---------EDALLR-MREEYG 263
++L AE + L E L++ + ++ L A+L ++A LR + +
Sbjct: 269 AKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328
Query: 264 IQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGE 318
+ + +R++ E E A + M L +YQ+LL +K L +E+ YR LLEGE
Sbjct: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGE 383
>gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens]
Length = 664
Score = 90.5 bits (223), Expect = 9e-18
Identities = 94/355 (26%), Positives = 154/355 (43%), Gaps = 49/355 (13%)
Query: 11 EKAELQELNARLYDYVCRVRELERENLLL----------------------EEELRGRRG 48
EK +LQELN RL Y+ RVR LE EN L E EL R
Sbjct: 31 EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90
Query: 49 REGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGR 108
A+ +AR E +R++ EL EG+ A + L++L+ L + AA
Sbjct: 91 TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150
Query: 109 LDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRA 168
+E + EL + G A LEA LG +A+++ D R E R + + F+
Sbjct: 151 ALSEKRTLEGELHDLRGQVAKLEAALG--EAKKQLQDEMLRRVDAENRLQTMKEELDFQK 208
Query: 169 RATGPAAPPP------RLREVHDS----YALLVAESWRETVQLYEDEVRELEEALRRGQE 218
RL E+ + + +A++ +E +ED+V + ++ L +
Sbjct: 209 NIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYS 268
Query: 219 SRLQ-----AEEETRLCAQEAEALRREALGLEQLRARL---------EDALLR-MREEYG 263
++L AE + L E L++ + ++ L A+L ++A LR + +
Sbjct: 269 AKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328
Query: 264 IQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGE 318
+ + +R++ E E A + M L +YQ+LL +K L +E+ YR LLEGE
Sbjct: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGE 383
>gi|14917119 keratin 34 [Homo sapiens]
Length = 436
Score = 89.4 bits (220), Expect = 2e-17
Identities = 86/320 (26%), Positives = 140/320 (43%), Gaps = 20/320 (6%)
Query: 9 GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR-RGREGLWAEGQARCAEEARSL 67
G EK +Q LN RL Y+ +VR+LER+N LE+ ++ R + +E L + L
Sbjct: 96 GSEKETMQFLNDRLASYLEKVRQLERDNAELEKLIQERSQQQEPLLCPSYQSYFKTIEEL 155
Query: 68 RQQLDELSWATALAEGERDALRRELRELQRLDAE-----ERAARGRLDAELGAQQRELQE 122
+Q++ A AE R + + +L D E++ R +++++ + +R L E
Sbjct: 156 QQKI-----LCAKAENARLVVNIDNAKLASDDFRSKYQTEQSLRLLVESDINSIRRILDE 210
Query: 123 ALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLRE 182
++ LE+ + L+ E L HE +V LR++ R AP L +
Sbjct: 211 LTLCKSDLESQVESLREELICLKKNHEEEVNTLRSQLGD-----RLNVEVDTAPTVDLNQ 265
Query: 183 V----HDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALR 238
V Y LV + RE Q + + EL + + E + E + AL
Sbjct: 266 VLNETRSQYEALVEINRREVEQWFATQTEELNKQVVSSSEQLQSCQAEIIELRRTVNALE 325
Query: 239 REALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLL 298
E LR LE+ L Y Q + Q +I +E + A + + ++YQ LL
Sbjct: 326 IELQAQHNLRDSLENTLTESEAHYSSQLSQVQSLITNVESQLAEIRCDLERQNQEYQVLL 385
Query: 299 QVKTGLSLEVATYRALLEGE 318
V+ L E+ TYR+LLE E
Sbjct: 386 DVRARLECEINTYRSLLESE 405
>gi|195972866 keratin 10 [Homo sapiens]
Length = 584
Score = 89.4 bits (220), Expect = 2e-17
Identities = 79/319 (24%), Positives = 136/319 (42%), Gaps = 5/319 (1%)
Query: 6 LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEE-- 63
L +G EK +Q LN RL Y+ +VR LE N LE +++ + G +G+ R +
Sbjct: 141 LLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKYY 200
Query: 64 --ARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQ 121
L+ Q+ L+ A + D R + + E A R ++A++ +R L
Sbjct: 201 KTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLD 260
Query: 122 EALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLR 181
E +A LE + L E L HE ++++LR ++ ++ A L
Sbjct: 261 ELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLR-NVSTGDVNVEMNAAPGVDLTQLLN 319
Query: 182 EVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREA 241
+ Y L ++ ++ + ++ +EL + E + E + +AL E
Sbjct: 320 NMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIEL 379
Query: 242 LGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVK 301
L+ LE +L Y +Q + Q I LE++ + +YQ LL +K
Sbjct: 380 QSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIK 439
Query: 302 TGLSLEVATYRALLEGESN 320
L E+ TYR+LLEGE +
Sbjct: 440 IRLENEIQTYRSLLEGEGS 458
>gi|24430190 keratin 15 [Homo sapiens]
Length = 456
Score = 87.4 bits (215), Expect = 8e-17
Identities = 84/326 (25%), Positives = 141/326 (43%), Gaps = 25/326 (7%)
Query: 6 LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEAR 65
L +G EK +Q LN RL Y+ +VR LE N LE ++ W + Q + E
Sbjct: 100 LLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHD-------WYQKQTPTSPECD 152
Query: 66 SLR-----QQLDELSWATALAEG----ERDALRRELRELQRLDAEERAARGRLDAELGAQ 116
+ ++L + AT + E D R + + E A R ++A++
Sbjct: 153 YSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGL 212
Query: 117 QRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAP 176
+R L E AR LE + L E L HE +++E ++ A + AAP
Sbjct: 213 RRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAG-----QVNVEMDAAP 267
Query: 177 PPRLR----EVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQ 232
L E+ + Y + ++ R+ + + EL + + E ++ E +
Sbjct: 268 GVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRR 327
Query: 233 EAEALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLR 292
+ L E ++A LE++L Y Q ++ Q +I LE + + L M +
Sbjct: 328 TMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQ 387
Query: 293 DYQDLLQVKTGLSLEVATYRALLEGE 318
+Y+ LL +KT L E+ATYR+LLEG+
Sbjct: 388 EYKMLLDIKTRLEQEIATYRSLLEGQ 413
>gi|24234699 keratin 19 [Homo sapiens]
Length = 400
Score = 87.0 bits (214), Expect = 1e-16
Identities = 89/328 (27%), Positives = 141/328 (42%), Gaps = 26/328 (7%)
Query: 6 LQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEAR 65
L G EK +Q LN RL Y+ +VR LE N LE ++R ++G G +R
Sbjct: 75 LLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQG---PGPSRDYSHYY 131
Query: 66 SLRQQL-DELSWATALAEGERDALRRELRELQRLDAE-----ERAARGRLDAELGAQQRE 119
+ Q L D++ AT E R L+ + L D E+A R ++A++ +R
Sbjct: 132 TTIQDLRDKILGATI--ENSRIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRV 189
Query: 120 LQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPR 179
L E AR LE + L+ E L HE ++ LR + A G
Sbjct: 190 LDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAPGTDLAKI- 248
Query: 180 LREVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRR 239
L ++ Y ++ ++ ++ + EL + G +LQ + E LRR
Sbjct: 249 LSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVA-GHTEQLQ------MSRSEVTDLRR 301
Query: 240 EALGLE-------QLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLR 292
GLE ++A LED L +G Q Q +I +E + + +
Sbjct: 302 TLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQ 361
Query: 293 DYQDLLQVKTGLSLEVATYRALLEGESN 320
+YQ L+ +K+ L E+ATYR+LLEG+ +
Sbjct: 362 EYQRLMDIKSRLEQEIATYRSLLEGQED 389
>gi|5031877 lamin B1 [Homo sapiens]
Length = 586
Score = 87.0 bits (214), Expect = 1e-16
Identities = 102/362 (28%), Positives = 162/362 (44%), Gaps = 51/362 (14%)
Query: 5 RLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGR---RGRE--GLWAEGQAR 59
RL EK EL+ELN RL Y+ +VR LE EN L+ ++ R RGRE GL A +
Sbjct: 26 RLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETE 85
Query: 60 CAEEARSLRQQLDE---LSWATALAEGERDALRRELRELQRLDAEERAARGRL---DAEL 113
A+ R+L E L + E D L L + +++ A+ +L +A L
Sbjct: 86 LADARRALDDTARERAKLQIELGKCKAEHDQL---LLNYAKKESDLNGAQIKLREYEAAL 142
Query: 114 GAQQRELQEALGARAALEALLGRLQAERRGLDA---------AHERDVR-ELRARAASLT 163
++ L ALG + +LE L L+ + L+A A E ++ +L R SLT
Sbjct: 143 NSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLT 202
Query: 164 MHFRARATGPAAPPPRLREVHDS------------YALLVAESWRETVQLYEDEVRELEE 211
R + R H++ Y +A++ E + ++ +VR +E
Sbjct: 203 EDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKE 262
Query: 212 ALRRG-----QESRLQAEEETRLCAQEAEALRREALGLEQLRARLED-------ALLRMR 259
L + + +RL +E T E L + +E L ++L + L R++
Sbjct: 263 ELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQ 322
Query: 260 EEYGIQAEER---QRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLE 316
E + A+E+ +R++ E E A + M L DY+ LL VK L +E++ YR LLE
Sbjct: 323 ELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLE 382
Query: 317 GE 318
GE
Sbjct: 383 GE 384
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,821,352
Number of Sequences: 37866
Number of extensions: 2336876
Number of successful extensions: 18426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 287
Number of HSP's successfully gapped in prelim test: 776
Number of HSP's that attempted gapping in prelim test: 10396
Number of HSP's gapped (non-prelim): 5101
length of query: 1253
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1139
effective length of database: 13,930,794
effective search space: 15867174366
effective search space used: 15867174366
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.