Search of human proteins with 90652857

Search of human proteins with 90652857

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|90652857 hypothetical protein LOC84904 [Homo sapiens]
         (335 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|90652857 hypothetical protein LOC84904 [Homo sapiens]              690   0.0  
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]             96   5e-20
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]    78   1e-14
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    77   2e-14
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    77   2e-14
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    75   6e-14
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                74   2e-13
gi|71274148 pleckstrin homology domain containing, family G (wit...    70   3e-12
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    68   1e-11
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    68   1e-11
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    68   1e-11
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    67   3e-11
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom...    65   9e-11
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...    63   3e-10
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    63   3e-10
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]    63   4e-10
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              62   7e-10
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]    62   7e-10
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    60   2e-09
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    60   3e-09
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    60   4e-09
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    60   4e-09
gi|23308553 spermatogenesis associated 13 [Homo sapiens]               58   1e-08
gi|118150678 epithelial cell transforming sequence 2 oncogene-li...    57   2e-08
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    57   3e-08
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...    56   5e-08
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ...    55   7e-08
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...    55   7e-08
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    55   1e-07
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]              54   2e-07

>gi|90652857 hypothetical protein LOC84904 [Homo sapiens]
          Length = 335

 Score =  690 bits (1780), Expect = 0.0
 Identities = 335/335 (100%), Positives = 335/335 (100%)

Query: 1   MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRP 60
           MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRP
Sbjct: 1   MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRP 60

Query: 61  PERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQ 120
           PERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQ
Sbjct: 61  PERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQ 120

Query: 121 LKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQL 180
           LKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQL
Sbjct: 121 LKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQL 180

Query: 181 TRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPH 240
           TRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPH
Sbjct: 181 TRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPH 240

Query: 241 GEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLL 300
           GEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLL
Sbjct: 241 GEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLL 300

Query: 301 SLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN 335
           SLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN
Sbjct: 301 SLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN 335


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 92/349 (26%), Positives = 149/349 (42%), Gaps = 39/349 (11%)

Query: 12  VQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWE 71
           + +Q +  ERKR     E+L +E  YQ  L ++   FL   + + T+   E   LF +  
Sbjct: 274 ILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNIL 333

Query: 72  LIYGASQELLPYLEGGCWGQGL---------EGFCRHLELYNQFAANSERSQTTLQEQLK 122
            + GASQ     LE     Q L         E   +H   Y  + +N    Q TLQ+ + 
Sbjct: 334 DVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLIS 393

Query: 123 KNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTR 182
            N  FR  +R  E RP  GGL +   L LP+QR+ +   L+  L   T  +S  ++  +R
Sbjct: 394 SNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASR 453

Query: 183 AARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGL---TSGRWFLRQGWLLVVPP 239
           A + IS+  ++ +    + +  + +  +   L   + K L   ++ RW L++G L +V  
Sbjct: 454 ALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEE 513

Query: 240 HG-----EPRPRMF-FLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVF-GHS 292
            G       RP  + FLF DVL++ K +         ++  +    M    + ++     
Sbjct: 514 TGLFRKIASRPTCYLFLFNDVLVVTKKK------SEESYMVQDYAQMNHIQVEKIEPSEL 567

Query: 293 GGPCGGLLSLSFPH--------------EKLLLMSTDQEELSRWYHSLT 327
             P GG  S S PH              E+LLL S    + +RW  +LT
Sbjct: 568 PLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALT 616


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 51/162 (31%), Positives = 83/162 (51%), Gaps = 2/162 (1%)

Query: 99   HLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQ 158
            +L++Y+ +    +++   L EQ KKN GF   VR  E  P    L L+  L  P+QR+ Q
Sbjct: 962  YLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQ 1021

Query: 159  YENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQ 218
            Y  L+    +N   ++ D++    A  ++ E A   +   ++  N Q L ++Q  L+G  
Sbjct: 1022 YRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHH 1081

Query: 219  AKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKP 260
             + +  GR FL++G +L+       +PRMFFLF D LL   P
Sbjct: 1082 -EIVQPGRVFLKEG-ILMKLSRKVMQPRMFFLFNDALLYTTP 1121


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 55/204 (26%), Positives = 91/204 (44%), Gaps = 11/204 (5%)

Query: 20   ERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQE 79
            ERKR     EL++TE RY   L LV   F   +   G L   E   +F +W+ +  ++ +
Sbjct: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239

Query: 80   LLPYLE-----GG------CWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFR 128
            LL  L      GG        G  L     H++ Y +F +        LQ++  ++  F+
Sbjct: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299

Query: 129  RFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLIS 188
             F++     P   G+ L   L  P+QR+ +Y  L+ ++ ENT  +  DH  L  A     
Sbjct: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359

Query: 189  ETAQRVHTIGQKQKNDQHLRRVQA 212
            E   +V+   ++++N   L  +QA
Sbjct: 1360 ELCSQVNEGVREKENSDRLEWIQA 1383


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 55/204 (26%), Positives = 91/204 (44%), Gaps = 11/204 (5%)

Query: 20   ERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQE 79
            ERKR     EL++TE RY   L LV   F   +   G L   E   +F +W+ +  ++ +
Sbjct: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266

Query: 80   LLPYLE-----GG------CWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFR 128
            LL  L      GG        G  L     H++ Y +F +        LQ++  ++  F+
Sbjct: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1326

Query: 129  RFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLIS 188
             F++     P   G+ L   L  P+QR+ +Y  L+ ++ ENT  +  DH  L  A     
Sbjct: 1327 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1386

Query: 189  ETAQRVHTIGQKQKNDQHLRRVQA 212
            E   +V+   ++++N   L  +QA
Sbjct: 1387 ELCSQVNEGVREKENSDRLEWIQA 1410


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 100/339 (29%), Positives = 147/339 (43%), Gaps = 45/339 (13%)

Query: 6   PGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQ- 64
           PGS  P + +R          ARE++ETER Y   L  +   +LG L   G L     Q 
Sbjct: 95  PGSARPSRLERV---------AREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQV 145

Query: 65  -ALFGSWELIYGASQELLPYLE-----GG---CWGQGLEGFCRHLELYNQFAANSERSQT 115
             LF + E IY  S ELL  LE     GG   C+ Q  E F    ++Y  +  N   S  
Sbjct: 146 GTLFANIEDIYEFSSELLEDLENSSSAGGIAECFVQRSEDF----DIYTLYCMNYPSSLA 201

Query: 116 TLQEQLKKNKGFRRFVRLQEGRPEF-GGLQLQDLLPLPLQRLQQYENLVVALAEN--TGP 172
            L+E           + LQE + +    L LQ  L  P+QR+ +Y  L+  L ++   GP
Sbjct: 202 LLRELSLSPPA---ALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGP 258

Query: 173 NSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQG 232
            +   + +  A   ++  A  ++ + +KQ++   L+ VQ  L G     L++    + +G
Sbjct: 259 GTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEG 318

Query: 233 WLLVVPPHGEPR----PRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRV 288
                   G PR     R+ FLF+ +LL+AK R  L     G   C        C+LS V
Sbjct: 319 -AFRGGGGGGPRLRGGERLLFLFSRMLLVAK-RRGLEYTYKGHIFC--------CNLS-V 367

Query: 289 FGHSGGPCGGLLS-LSFPHEKLLLMSTDQEELSRWYHSL 326
                 P G  +S L+ P  + LL + +QEE   W H L
Sbjct: 368 SESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCL 406


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 69/268 (25%), Positives = 107/268 (39%), Gaps = 29/268 (10%)

Query: 20   ERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQE 79
            ERKR     EL+ TE  Y   L LV   F   L     L   E   +F +W+ +   + +
Sbjct: 1235 ERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIK 1294

Query: 80   LLPYLEGG-----------CWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFR 128
            LL  L                G  L     H++ Y +F +        +Q++  +   F+
Sbjct: 1295 LLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFK 1354

Query: 129  RFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLIS 188
             FV+     P   G+ L   +  P+QR+ +Y  ++  + ENT  N PDH  L  A     
Sbjct: 1355 EFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAE 1414

Query: 189  ETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLT------------SGRWFLRQGWLLV 236
            E   +V+   ++++N   L  +QA +   Q +GL+              R FL  G L  
Sbjct: 1415 ELCSQVNEGVREKENSDRLEWIQAHV---QCEGLSEQLVFNSVTNCLGPRKFLHSGKLYK 1471

Query: 237  VPPHGEPRPRMFFLFTDVLLMAKPRPPL 264
               + E      FLF D LL+ +   PL
Sbjct: 1472 AKSNKE---LYGFLFNDFLLLTQITKPL 1496


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 66/245 (26%), Positives = 112/245 (45%), Gaps = 20/245 (8%)

Query: 28  RELLETERRYQEQLGLVATYFLGILK--AKGTLRPPERQALFGSWELIYGASQELLPYLE 85
           +E+LETER Y + L  +   +L  ++   K  L   ER ALFG+ + IY  + ELL  LE
Sbjct: 119 QEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLE 178

Query: 86  ---------GGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEG 136
                      C+    E F     +Y Q+  N  RS   L E + +NK   +F R ++ 
Sbjct: 179 NCENDPVAIAECFVSKSEEF----HIYTQYCTNYPRSVAVLTECM-RNKILAKFFRERQE 233

Query: 137 RPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHT 196
             +   L L   L  P+QR+ +Y  L+  +  +   ++  +  +  A   +   A  ++ 
Sbjct: 234 TLKH-SLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIND 292

Query: 197 IGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLL 256
           + +K ++   L+ +Q+LL+  +   LTS    + +G   +     E   R  FLF  +LL
Sbjct: 293 MKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNE---RTLFLFDKLLL 349

Query: 257 MAKPR 261
           + K R
Sbjct: 350 ITKKR 354


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%)

Query: 28  RELLETERRYQEQLGLV-ATYFLGILK-AKGTLRPPER--QALFGSWELIYGA-SQELLP 82
           +ELLETE+ Y  +L L+   +F  +LK A+ +   PE   + +F +   IY   SQ  LP
Sbjct: 108 QELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLP 167

Query: 83  YLEGGC--W------GQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQ 134
            L+     W      G  ++     L++Y+++  N ER+   L     K+  F+  +   
Sbjct: 168 ELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRI 227

Query: 135 EGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRV 194
           +     G L LQ  +  P+QR+ +YE L+    +     +PD     +A  +I   AQ  
Sbjct: 228 QSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHS 287

Query: 195 HTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVP-PHGEPRPRMFFLFTD 253
           +    + +  Q L  V   L G +   +      LR+G +L +     +P  R  FLF +
Sbjct: 288 NAAITEMERLQDLWEVYQRL-GLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNN 346

Query: 254 VLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLLSLSFPHEKLL--- 310
           +LL   PR    +++ G          AQ  +      +G     L+   FPH  L+   
Sbjct: 347 MLLYCVPR----VIQVG----------AQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGK 392

Query: 311 -----LMSTDQEELSRWYHSLTWAI 330
                L +  QEE+  W  +   AI
Sbjct: 393 QRTLELQARSQEEMISWMQAFQAAI 417


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 57/244 (23%), Positives = 109/244 (44%), Gaps = 9/244 (3%)

Query: 22  KRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELL 81
           KR C   E+ ETE +Y   L  +   ++  L+    L P +  A+F + E +       L
Sbjct: 198 KRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL--VLSPADMAAVFINLEDLIKVHHSFL 255

Query: 82  PYLE------GGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQE 135
             ++      G    +    F   L +Y ++ ++ E +Q TL + L   + FR+ V    
Sbjct: 256 RAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECT 315

Query: 136 GRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVH 195
            + + G  +LQDLL +P+QR+ +Y  L+  L  ++    P+ QQL  A   + + A  ++
Sbjct: 316 LKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQDLAMYIN 374

Query: 196 TIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVL 255
            + + ++  + +   Q+ +   Q K    GR  +     +    +   + R  FLF  V+
Sbjct: 375 EVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVV 434

Query: 256 LMAK 259
           ++ K
Sbjct: 435 IVCK 438


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 57/244 (23%), Positives = 109/244 (44%), Gaps = 9/244 (3%)

Query: 22  KRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELL 81
           KR C   E+ ETE +Y   L  +   ++  L+    L P +  A+F + E +       L
Sbjct: 193 KRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL--VLSPADMAAVFINLEDLIKVHHSFL 250

Query: 82  PYLE------GGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQE 135
             ++      G    +    F   L +Y ++ ++ E +Q TL + L   + FR+ V    
Sbjct: 251 RAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECT 310

Query: 136 GRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVH 195
            + + G  +LQDLL +P+QR+ +Y  L+  L  ++    P+ QQL  A   + + A  ++
Sbjct: 311 LKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQDLAMYIN 369

Query: 196 TIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVL 255
            + + ++  + +   Q+ +   Q K    GR  +     +    +   + R  FLF  V+
Sbjct: 370 EVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVV 429

Query: 256 LMAK 259
           ++ K
Sbjct: 430 IVCK 433


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 70/271 (25%), Positives = 120/271 (44%), Gaps = 22/271 (8%)

Query: 8   SRCPV-QEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGT-----LRPP 61
           S  PV  +Q ARW+      A+EL +TE  Y   L  +   F   L+ +G      L P 
Sbjct: 411 SSTPVPSKQSARWQ-----VAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPE 465

Query: 62  ERQALFGSWELIYGASQELLPYLEGGC--WGQGL---EGFCRH----LELYNQFAANSER 112
           E + +FGS   I+    ++   LE     W +     + F ++    ++ Y  F    E 
Sbjct: 466 EIKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEM 525

Query: 113 SQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGP 172
           S+ T+ +  K+   F  F+++ + +PE G   L +LL  P+QRL     L+  L ++T  
Sbjct: 526 SKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTAD 585

Query: 173 NSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQG 232
            +PD   L +A   + E    ++   +K +  + +  V   + G  A  L+S R  +++ 
Sbjct: 586 ENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRV 645

Query: 233 WLLVVPPHGEPRPRM--FFLFTDVLLMAKPR 261
             + +  H   R      FLF D L +A+ R
Sbjct: 646 ETISLGEHPCDRGEQVTLFLFNDCLEIARKR 676


>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
           sapiens]
          Length = 802

 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 74/323 (22%), Positives = 118/323 (36%), Gaps = 31/323 (9%)

Query: 29  ELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGGC 88
           EL+ +E  Y   L +   +FLG  +    L   ++Q LF     +   S+  L  LE   
Sbjct: 383 ELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRL 442

Query: 89  WGQGLE-GFCRHL--------ELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPE 139
               L    C  +         +Y  +  N    + T Q  L +N  F   +   E  P 
Sbjct: 443 EADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPV 502

Query: 140 FGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQ 199
              L L   L LP QR+ + + LV  + + T   S D    T+A   + E  Q  +   Q
Sbjct: 503 CQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQ 562

Query: 200 KQKNDQHLRRVQALL--SGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPR---------MF 248
             K  + L  +   +   G+    ++  RW +R G L+ + P     P            
Sbjct: 563 SMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYL 622

Query: 249 FLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLLSLSFPH-- 306
            LF D LL+++ +        G FA      MA+  +  +     G  G +  L   H  
Sbjct: 623 HLFNDCLLLSRRK------ELGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLLHGQ 676

Query: 307 ---EKLLLMSTDQEELSRWYHSL 326
               + LL +  + E  RW  +L
Sbjct: 677 HMKHQFLLRARTESEKQRWISAL 699


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
           [Homo sapiens]
          Length = 1045

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 78/350 (22%), Positives = 137/350 (39%), Gaps = 45/350 (12%)

Query: 10  CPVQEQRARWERKRACT------ARELLETERRYQEQLGLVATYFLGILKAKGTLRPPER 63
           CP  +      RKR  T      A+E+  TER Y + L ++ ++F   +  +  +    +
Sbjct: 522 CPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALK 581

Query: 64  QALFGSWELIYGASQELLPYLEG--GCWG---------------------QGLEGFCRHL 100
             +F ++E ++      L  +E     W                      QG++    HL
Sbjct: 582 SLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHL 641

Query: 101 ELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYE 160
             +++       +   L+  +K ++    F R  E   +   L L   L  PL RL  Y+
Sbjct: 642 WKHSE-------ALEALENGIKSSRRLENFCRDFE-LQKVCYLPLNTFLLRPLHRLMHYK 693

Query: 161 NLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAK 220
            ++  L ++  P+  D +    A   I+E   ++H    K +N Q L  ++  L G    
Sbjct: 694 QVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGID-N 752

Query: 221 GLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPM 280
            +  GR F+R G L  +   G  + RMFFLF DVLL         L  S  F      P+
Sbjct: 753 LVVPGREFIRLGSLSKLSGKG-LQQRMFFLFNDVLLYTS----RGLTASNQFKVHGQLPL 807

Query: 281 AQCHLSRVFGHSGGPCGGLLSLSFPHEKLLLMSTDQEELSRWYHSLTWAI 330
               +       G P    L+L    + +++ ++ + E+ +W   +  AI
Sbjct: 808 YGMTIEESEDEWGVP--HCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAI 855


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 72/279 (25%), Positives = 120/279 (43%), Gaps = 31/279 (11%)

Query: 4   SCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKA-------KG 56
           S PG  C    +  R  R R C   E+L TER Y   L  + + FL  ++        KG
Sbjct: 32  SGPGP-CAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKG 90

Query: 57  TLRPPERQALFGSWELIYGASQELLPYLE-------------GGCWGQGLEGFCRHLELY 103
            L     + LF + E I    ++ L  LE             G  + +  + FC    +Y
Sbjct: 91  -LTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFC----VY 145

Query: 104 NQFAANSERSQTTLQEQLKKNKGFRRFVR--LQEGRPEFGGLQLQDLLPLPLQRLQQYEN 161
            ++ +N E++   L E L K    R F+   +  G  +   + L+  L  P+QR+ +Y  
Sbjct: 146 EEYCSNHEKALRLLVE-LNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPL 204

Query: 162 LVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKG 221
           L+  LA+ T    PDH  +  A + +      ++   ++ +  + L ++Q+ + G +   
Sbjct: 205 LLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSN 264

Query: 222 LTS-GRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAK 259
           LT      L QG LL +   G  + R FFLF ++L+  K
Sbjct: 265 LTDICTQLLLQGTLLKISA-GNIQERAFFLFDNLLVYCK 302


>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 61/258 (23%), Positives = 97/258 (37%), Gaps = 31/258 (12%)

Query: 29   ELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGGC 88
            EL+ +E  Y   L +   +F      + TL   E Q LF   + +   S   L  LE   
Sbjct: 1181 ELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENF 1240

Query: 89   WG-----QGLEGFCRHL----ELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPE 139
                   Q  +    H      +Y  +  N    + T Q  +  N  FR  +   E  P 
Sbjct: 1241 ENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPV 1300

Query: 140  FGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQ 199
               L L+  L LP QR+ + + L+  + + T P S +  + T+A   + +       I  
Sbjct: 1301 CQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQ------LIRD 1354

Query: 200  KQKNDQHLRRVQALLSGRQA--------KGLTSGRWFLRQGWLLVVPPHGEP-------- 243
               N Q +RR + L+   Q           ++  RW ++ G L  +     P        
Sbjct: 1355 CNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPGLRRKLNT 1414

Query: 244  RPRMFFLFTDVLLMAKPR 261
            RP    LF D LL+++PR
Sbjct: 1415 RPVHLHLFNDCLLLSRPR 1432


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 61/249 (24%), Positives = 110/249 (44%), Gaps = 15/249 (6%)

Query: 27  ARELLETERRYQEQLGLVATYFLGIL----KAKGTLRPPERQALFGSWELIYGASQE-LL 81
           A ELL+TE+ Y  +L L+   F   L    + + +        +F +   IY   Q+ LL
Sbjct: 378 ANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLL 437

Query: 82  PYLEGGC--W------GQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRL 133
           P LE     W      G  L+     L++Y ++  N +R+   +    +++  F+  +  
Sbjct: 438 PELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHE 497

Query: 134 QEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQR 193
            +     G L LQ  +  P+QR+ +YE L+          SPD +   ++  LI+  A+ 
Sbjct: 498 VQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEH 557

Query: 194 VHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLL-VVPPHGEPRPRMFFLFT 252
            +   +K +    L +V  LL G +   ++  +  +++G +L +   +G  + R   LF 
Sbjct: 558 SNAAIRKMERMHKLLKVYELLGGEE-DIVSPTKELIKEGHILKLSAKNGTTQDRYLILFN 616

Query: 253 DVLLMAKPR 261
           D LL   PR
Sbjct: 617 DRLLYCVPR 625


>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
          Length = 1462

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 85/344 (24%), Positives = 131/344 (38%), Gaps = 36/344 (10%)

Query: 8    SRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGIL---------KAKGTL 58
            SR P    +   + +    A+ELL +E+ Y E L  +   F G +         + + TL
Sbjct: 878  SRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTL 937

Query: 59   RPPERQALFGSWELIYGASQELLPYLEGGC--WGQGL----------EGFCRHLELYNQF 106
               E +        I+   Q +L  LE     W              +GF  H     QF
Sbjct: 938  AREELRQGLSELPAIHDLHQGILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQF 997

Query: 107  AANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVAL 166
                +R    L E    +      VR  E   + G    +  L   +QRL QY+ L+   
Sbjct: 998  ----DRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDY 1053

Query: 167  AENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGR 226
              N  P+S ++     A  LIS+   R +   ++ +N Q L  ++  + G Q   L  GR
Sbjct: 1054 LNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRG-QGDLLQPGR 1112

Query: 227  WFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLS 286
             FL++G L+ V      RPR  FL  DVLL   P+      + G +  K    +A   +S
Sbjct: 1113 EFLKEGTLMKVTGKNR-RPRHLFLMNDVLLYTYPQ------KDGKYRLKNTLAVANMKVS 1165

Query: 287  RVFGHSGGPCGGLLSLSFPHEKLLLMSTDQEELSRWYHSLTWAI 330
            R            L +      L+L ++   E   WY  L+ A+
Sbjct: 1166 RPVMEK---VPYALKIETSESCLMLSASSCAERDEWYGCLSRAL 1206


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 44/161 (27%), Positives = 81/161 (50%), Gaps = 6/161 (3%)

Query: 100  LELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQY 159
            + +Y+ +  N   ++  ++   +    F +F+  Q  R       L DL+  P+QR+ +Y
Sbjct: 1158 VNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLE-QSMRENKEKQALSDLMIKPVQRIPRY 1216

Query: 160  ENLVVALAENTGPNSPDHQQLTRAARLISETAQR----VHTIGQKQKNDQHLRRVQALLS 215
            E LV  L ++T  + PDH  L  A R I + A+R    V +  + +++ + L+ ++A + 
Sbjct: 1217 ELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIE 1276

Query: 216  GRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLL 256
            G +       R FLRQ  ++ V   G  + R  FLFTD+++
Sbjct: 1277 GMEDLQAPLRR-FLRQEMVIEVKAIGGKKDRSLFLFTDLIV 1316


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 56/260 (21%), Positives = 108/260 (41%), Gaps = 18/260 (6%)

Query: 20  ERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQE 79
           ERKR     E++ +E  Y   L ++   F    +   T+   ER  LF +   +  AS++
Sbjct: 437 ERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKK 496

Query: 80  LLPYLEGGCWGQGL---------EGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRF 130
               LE                 +      + Y ++  N    Q TLQ+ L  N  F+  
Sbjct: 497 FFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEV 556

Query: 131 VRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISET 190
           +   E   +   L +   L LP+QR+ +   L+  + + T  +SP ++   RA + +S+ 
Sbjct: 557 LSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKL 616

Query: 191 AQRVHTIGQKQKNDQHLRRVQALLSG--RQAKGLTSGRWFLRQGWL-------LVVPPHG 241
            +  +   +K +  + +  + + L    +    ++S RW +++G L       ++     
Sbjct: 617 VRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRT 676

Query: 242 EPRPRMFFLFTDVLLMAKPR 261
             +   FFLF DVL++ K +
Sbjct: 677 SKQQVYFFLFNDVLIITKKK 696


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 62/247 (25%), Positives = 109/247 (44%), Gaps = 15/247 (6%)

Query: 27  ARELLETERRYQEQLGLVATYFLGILKAKGTLRPPER-QALFGSWELIYGA-SQELLPYL 84
           A+ELL TE  Y ++L L+   F   L   G   PPE    +F +   I+    Q LLP L
Sbjct: 162 AQELLHTEETYVKRLHLLDQVFCTRLTDAGI--PPEVIMGIFSNISSIHRFHGQFLLPEL 219

Query: 85  EGGC---W------GQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQE 135
           +      W      G  L+     L++Y ++  N +R+   +    +++  F+  V   +
Sbjct: 220 KTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQ 279

Query: 136 GRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVH 195
            +   G L LQ  +  P+QR+ +YE L+    +    ++PD +   R+  LIS  A   +
Sbjct: 280 KQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSN 339

Query: 196 TIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWL-LVVPPHGEPRPRMFFLFTDV 254
              +K +    L  V   L G +   +      +++G +  +   +G P+ R  FLF  +
Sbjct: 340 AAIRKVEKMHKLLEVYEQLGGEE-DIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSM 398

Query: 255 LLMAKPR 261
           +L   P+
Sbjct: 399 ILYCVPK 405


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 62/247 (25%), Positives = 109/247 (44%), Gaps = 15/247 (6%)

Query: 27  ARELLETERRYQEQLGLVATYFLGILKAKGTLRPPER-QALFGSWELIYGA-SQELLPYL 84
           A+ELL TE  Y ++L L+   F   L   G   PPE    +F +   I+    Q LLP L
Sbjct: 162 AQELLHTEETYVKRLHLLDQVFCTRLTDAGI--PPEVIMGIFSNISSIHRFHGQFLLPEL 219

Query: 85  EGGC---W------GQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQE 135
           +      W      G  L+     L++Y ++  N +R+   +    +++  F+  V   +
Sbjct: 220 KTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQ 279

Query: 136 GRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVH 195
            +   G L LQ  +  P+QR+ +YE L+    +    ++PD +   R+  LIS  A   +
Sbjct: 280 KQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSN 339

Query: 196 TIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWL-LVVPPHGEPRPRMFFLFTDV 254
              +K +    L  V   L G +   +      +++G +  +   +G P+ R  FLF  +
Sbjct: 340 AAIRKVEKMHKLLEVYEQLGGEE-DIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSM 398

Query: 255 LLMAKPR 261
           +L   P+
Sbjct: 399 ILYCVPK 405


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 80/353 (22%), Positives = 132/353 (37%), Gaps = 41/353 (11%)

Query: 2   ELSCPGSRCPVQEQ--RARWERKRAC---------TARELLETERRYQEQL-GLVATYFL 49
           ELS   S  P +EQ   A   R R C           RE+++TER Y + L  +   Y  
Sbjct: 209 ELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIR 268

Query: 50  GILKAKGTLRPPERQALFGSWELIYGASQELLPYLE-------------GGCWGQGLEGF 96
              K  G     +   +FG+ E IY   ++ L  LE             G C+ Q  EGF
Sbjct: 269 QCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGF 328

Query: 97  CRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRL 156
                +Y+++  N   +   L   +K+ K +R F        +   + +   L  P+Q++
Sbjct: 329 A----IYSEYCNNHPGACLELANLMKQGK-YRHFFEACRLLQQMIDIAIDGFLLTPVQKI 383

Query: 157 QQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSG 216
            +Y   +  L + T     D+  +  A   +   A  ++   +K ++   + R Q  + G
Sbjct: 384 CKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVG 443

Query: 217 RQAKG-LTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACK 275
            +    L      +  G L  +   G+ + R FFLF   L+  K      LLR      K
Sbjct: 444 WEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKK----DLLRRDMLYYK 499

Query: 276 ALYPMAQCHLSRVFGHSGGPCGGLLSLSF------PHEKLLLMSTDQEELSRW 322
               M +  L  +       C   +  +F        E  L  +  QE+ +RW
Sbjct: 500 GRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARW 552


>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
           [Homo sapiens]
          Length = 904

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 53/208 (25%), Positives = 87/208 (41%), Gaps = 13/208 (6%)

Query: 22  KRACTARELLETERRYQEQLGLVATYFLGILKA-----KGTLRPPERQALFGSWELIYGA 76
           KRA   RELL++ER+Y + L +V   ++  LKA     +  L     Q +F     I   
Sbjct: 566 KRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSL 625

Query: 77  SQELLPYLE--------GGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFR 128
           +++ L  L           C G+ +  F   L  Y  F  N      T+++  +    FR
Sbjct: 626 NRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFR 685

Query: 129 RFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLIS 188
            F++  +       L L +LL  P +R ++Y NL+ A+  +T     D   LT A   I 
Sbjct: 686 TFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIK 745

Query: 189 ETAQRVHTIGQKQKNDQHLRRVQALLSG 216
           +    +  + Q      HL  +Q ++ G
Sbjct: 746 KYKGYIDQMKQNITMKDHLSDIQRIIWG 773


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 60/261 (22%), Positives = 115/261 (44%), Gaps = 14/261 (5%)

Query: 14  EQRARWERKRACTARELLETERRYQEQLGLV-ATYFLGILKA--KGTLRPPERQALFGSW 70
           E +   E+K    A ELL TER Y  +L L+   ++  +L+   +G+        +F + 
Sbjct: 198 EMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNI 257

Query: 71  ELIYGA-SQELLPYLEGGC--W------GQGLEGFCRHLELYNQFAANSERSQTTLQEQL 121
             I    S+ LLP LE     W      G  L+     L++Y ++    + +   ++   
Sbjct: 258 SSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMT 317

Query: 122 KKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLT 181
           ++   F+  V   + +   G L LQ  +  P+QR+ +YE L+        P+S D     
Sbjct: 318 ERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAK 377

Query: 182 RAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLL-VVPPH 240
           ++  +IS  A   ++  +K +N + L  +  +L G +   +      +++G +L +   +
Sbjct: 378 KSLEIISTAASHSNSAIRKMENLKKLLEIYEML-GEEEDIVNPSNELIKEGQILKLAARN 436

Query: 241 GEPRPRMFFLFTDVLLMAKPR 261
              + R  FLF ++LL   P+
Sbjct: 437 TSAQERYLFLFNNMLLYCVPK 457


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 66/249 (26%), Positives = 106/249 (42%), Gaps = 26/249 (10%)

Query: 28  RELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLE-- 85
           +E+L TER Y + L ++  +F   +  +  +       LF + + IY   +  L  +E  
Sbjct: 541 KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR 600

Query: 86  ------------GGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRL 133
                        G   +  +   R++    +F +  +R    L E  K  K   R  +L
Sbjct: 601 LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATK---RCKKL 657

Query: 134 QEGRPEFGGLQLQDLLPL------PLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLI 187
           +    EF  LQ    LPL      P+QRL  Y  L+  L  +  P   D+     A + I
Sbjct: 658 EAVYKEF-ELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAI 716

Query: 188 SETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRM 247
           +E    +  I  + +N Q L  +Q  L G +   +  GR F+R+G L  +   G  + RM
Sbjct: 717 TEVTTTLQHILIRLENLQKLTELQRDLVGIE-NLIAPGREFIREGCLHKLTKKG-LQQRM 774

Query: 248 FFLFTDVLL 256
           FFLF+D+LL
Sbjct: 775 FFLFSDMLL 783


>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
           [Homo sapiens]
          Length = 626

 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 47/189 (24%), Positives = 81/189 (42%), Gaps = 23/189 (12%)

Query: 28  RELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGG 87
           +EL++TE+ Y + L  +   +L  L+ +  L   E ++LFGS   +    +  L  LE G
Sbjct: 30  QELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDG 89

Query: 88  ---------------------CWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKG 126
                                  G     +  H +LY+ F AN  + Q  L E+ K +K 
Sbjct: 90  ISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVL-ERAKTDKA 148

Query: 127 FRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARL 186
           F+ F+  +    +     L+  L  P+QR+ +Y  L+  L   T   S +H  LT A + 
Sbjct: 149 FKAFLDARNPTKQHSS-TLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKA 207

Query: 187 ISETAQRVH 195
           + + A  ++
Sbjct: 208 MEKVASHIN 216


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
            sapiens]
          Length = 1701

 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 47/189 (24%), Positives = 81/189 (42%), Gaps = 23/189 (12%)

Query: 28   RELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGG 87
            +EL++TE+ Y + L  +   +L  L+ +  L   E ++LFGS   +    +  L  LE G
Sbjct: 1105 QELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDG 1164

Query: 88   ---------------------CWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKG 126
                                   G     +  H +LY+ F AN  + Q  L E+ K +K 
Sbjct: 1165 ISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVL-ERAKTDKA 1223

Query: 127  FRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARL 186
            F+ F+  +    +     L+  L  P+QR+ +Y  L+  L   T   S +H  LT A + 
Sbjct: 1224 FKAFLDARNPTKQHSS-TLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKA 1282

Query: 187  ISETAQRVH 195
            + + A  ++
Sbjct: 1283 MEKVASHIN 1291


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 79/346 (22%), Positives = 139/346 (40%), Gaps = 51/346 (14%)

Query: 12   VQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQA----LF 67
            ++E+++   ++R    +EL+ETER Y   LG V   ++ ++K  G   P + +     +F
Sbjct: 1959 MEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGV--PDDMKGKDKIVF 2016

Query: 68   GSWELIYGASQEL-LPYLEGGCWGQGLEG--FCRH---LELYNQFAANSERSQ------- 114
            G+   IY   ++  L  LE         G  F +H   L +Y  +  N  +S+       
Sbjct: 2017 GNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYI 2076

Query: 115  TTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNS 174
             T  E LK+  G R              LQL DLL  P+QR+ +Y+ L+    + +   S
Sbjct: 2077 DTFFEDLKQRLGHR--------------LQLTDLLIKPVQRIMKYQLLLKDFLKYSKKAS 2122

Query: 175  PDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWL 234
             D  +L RA  ++    +R + +        ++ R+Q    G   K +  G+  L+  +L
Sbjct: 2123 LDTSELERAVEVMCIVPRRCNDM-------MNVGRLQ----GFDGKIVAQGKLLLQDTFL 2171

Query: 235  LVVPPHG---EPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGH 291
            +     G     R R  FLF  +++ ++P           F  K    ++   L      
Sbjct: 2172 VTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEE--NV 2229

Query: 292  SGGPCGGLLSLSFPH--EKLLLMSTDQEELSRWYHSLTWAISSQKN 335
               PC   L+       E  +L S+       W H +   + +Q+N
Sbjct: 2230 ENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRN 2275


>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
          Length = 841

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 71/318 (22%), Positives = 119/318 (37%), Gaps = 39/318 (12%)

Query: 20  ERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQE 79
           ER+   +  E++ +E  Y   L L+   F+     + TL P +   LF + + + G S+ 
Sbjct: 415 ERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSER 474

Query: 80  LL----------PYLEGGC---WGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKG 126
            L          P++   C       +  F     +Y  +  N +  + T    +  N  
Sbjct: 475 FLATLLSRVRSSPHISDLCDVVHAHAVGPF----SVYVDYVRNQQYQEETYSRLMDTNVR 530

Query: 127 FRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARL 186
           F   +R  +  P+   L L   L LP QR+ +   L+  +   T   S   +   +A   
Sbjct: 531 FSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGA 590

Query: 187 ISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLR---QGWLLVVPPH--- 240
           +S+  +R      + K  + L R+   L   + K L    W  R   QG L  +      
Sbjct: 591 VSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGG 650

Query: 241 ----GEPR--PRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQC---------HL 285
                 PR  P    LF+D+LL+ +P+     L+   +A ++L    Q           L
Sbjct: 651 VLFASRPRFTPLCLLLFSDLLLITQPKSG-QRLQVLDYAHRSLVQAQQVPDPSGPPTFRL 709

Query: 286 SRVFGHSGGPCGGLLSLS 303
           S +  H G P   LL  S
Sbjct: 710 SLLSNHQGRPTHRLLQAS 727


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,240,731
Number of Sequences: 37866
Number of extensions: 672702
Number of successful extensions: 1814
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 1697
Number of HSP's gapped (non-prelim): 121
length of query: 335
length of database: 18,247,518
effective HSP length: 103
effective length of query: 232
effective length of database: 14,347,320
effective search space: 3328578240
effective search space used: 3328578240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.