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Search of human proteins with 63055059
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63055059 SH3 and PX domains 2B [Homo sapiens]
(911 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63055059 SH3 and PX domains 2B [Homo sapiens] 1875 0.0
gi|55749544 SH3 multiple domains 1 [Homo sapiens] 528 e-149
gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens] 207 4e-53
gi|41281811 NADPH oxidase organizer 1 isoform b [Homo sapiens] 86 2e-16
gi|41281828 NADPH oxidase organizer 1 isoform c [Homo sapiens] 84 8e-16
gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens] 81 4e-15
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 67 8e-11
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 67 8e-11
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 67 8e-11
gi|47519798 neutrophil cytosolic factor 4 isoform 1 [Homo sapiens] 67 1e-10
gi|163644267 neutrophil cytosolic factor 4 isoform 2 [Homo sapiens] 67 1e-10
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 67 1e-10
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 66 1e-10
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 66 2e-10
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 66 2e-10
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 64 5e-10
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 64 5e-10
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 61 5e-09
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 61 5e-09
gi|20149528 proline-serine-threonine phosphatase interacting pro... 59 3e-08
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 57 8e-08
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 57 8e-08
gi|150170670 piccolo isoform 2 [Homo sapiens] 57 8e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 57 8e-08
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 56 2e-07
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 56 2e-07
gi|150417989 cyclin K isoform 1 [Homo sapiens] 55 2e-07
gi|47132519 Ras association and pleckstrin homology domains 1 is... 55 4e-07
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 54 9e-07
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 53 1e-06
>gi|63055059 SH3 and PX domains 2B [Homo sapiens]
Length = 911
Score = 1875 bits (4857), Expect = 0.0
Identities = 911/911 (100%), Positives = 911/911 (100%)
Query: 1 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP 60
MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
Sbjct: 1 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP 60
Query: 61 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ 120
MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
Sbjct: 61 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ 120
Query: 121 FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD 180
FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD
Sbjct: 121 FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD 180
Query: 181 IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM 240
IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM
Sbjct: 181 IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM 240
Query: 241 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL 300
NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL
Sbjct: 241 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL 300
Query: 301 DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL 360
DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL
Sbjct: 301 DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL 360
Query: 361 PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT 420
PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT
Sbjct: 361 PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT 420
Query: 421 FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS 480
FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS
Sbjct: 421 FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS 480
Query: 481 GLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERE 540
GLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERE
Sbjct: 481 GLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERE 540
Query: 541 RERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGH 600
RERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGH
Sbjct: 541 RERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGH 600
Query: 601 KVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQ 660
KVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQ
Sbjct: 601 KVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQ 660
Query: 661 VDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS 720
VDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS
Sbjct: 661 VDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS 720
Query: 721 PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG 780
PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG
Sbjct: 721 PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG 780
Query: 781 PQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAA 840
PQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAA
Sbjct: 781 PQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAA 840
Query: 841 AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEG 900
AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEG
Sbjct: 841 AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEG 900
Query: 901 WIPSNYLRKKP 911
WIPSNYLRKKP
Sbjct: 901 WIPSNYLRKKP 911
>gi|55749544 SH3 multiple domains 1 [Homo sapiens]
Length = 1105
Score = 528 bits (1359), Expect = e-149
Identities = 326/776 (42%), Positives = 426/776 (54%), Gaps = 109/776 (14%)
Query: 7 IVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQK 66
+ + V+DV+KRR P+KHYVYII VTWS +++ IYRRYSKFFDLQMQ+LDKFP+EGGQK
Sbjct: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQK 65
Query: 67 DPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRP 126
DPKQRIIPFLPGKILFRRSHIRDVAVKRL PIDEYC+AL++LPP+ISQCDEV +FFE RP
Sbjct: 66 DPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARP 125
Query: 127 EDLNPPKEEHIGKKKSG---------------GDQTSVDPMVLEQYVVVANYQKQESSEI 171
ED+NPPKE++ K+ G + +PM+LEQYVVV+NY+KQE+SE+
Sbjct: 126 EDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSEL 185
Query: 172 SLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE---EEEKYTV 228
SL G+VVD+IEKNESGWWFVST+EEQGWVPAT LE Q+G +D+ + EEEKY
Sbjct: 186 SLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVT 245
Query: 229 IYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK----------- 277
+ PYT++ +DE+ E+G VEVI+KNLEGWW IRY GKEGWAPASYLKK
Sbjct: 246 VQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKN 305
Query: 278 ----------------------NSGEPLPPKPGPG--SPSHPGALDLDGVSRQQN--AVG 311
+ + PP G G +P + L + N AVG
Sbjct: 306 LAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVG 365
Query: 312 REKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEE 371
+S G + A+ SP +R RPPPRR+ ++ G LPKPP PP VE
Sbjct: 366 VPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPPEPPSVEV 423
Query: 372 EYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKK---- 427
EYYTIAEFQ+ I DGISF+ G K EVI+KN GWWY+QI +KEGWAPA++IDK KK
Sbjct: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLS 483
Query: 428 --TSNASRPNFLAPL-PHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPW 484
TS +RP P P + + G A E+ P D P DS
Sbjct: 484 RRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPEL 543
Query: 485 SKDWKGSKDVLRKASSDMSASAGYEEISDPDMEE-KPSLPPRKESIIKSEGELLERERER 543
S++ V +AS + + + ++ + + E + E + E E R
Sbjct: 544 SEE-----PVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFR 598
Query: 544 ---QRTEQLRGPT--PKPPGVILPMMPAKHIPPA---RDSRRPEPKPDKSRLFQL-KNDM 594
+ T RG + PG + K+ P + + S + K +K+ ++ KN
Sbjct: 599 PYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHS 658
Query: 595 GLECGHKVLAKEV----KKPNLRPISKSKTDL-PEEKPDA----TPQ---------NPFL 636
+ + +SK+ DL P DA TP+ N L
Sbjct: 659 SASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGL 718
Query: 637 KSRPQVRPKPAPSP--KTEPPQGEDQVDICNLRSKLRP----------AKSQDKSL 680
S P+ +P P P Q ++++DI LR +LRP +KS+D L
Sbjct: 719 TSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSEL 774
Score = 87.4 bits (215), Expect = 5e-17
Identities = 35/63 (55%), Positives = 50/63 (79%), Gaps = 1/63 (1%)
Query: 848 DGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL 907
+ LKD +YV++AD+EGD++T+ FQEG EV E+N +GWW+CQ+L G ++GW+PSNYL
Sbjct: 1043 NNLKD-VYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYL 1101
Query: 908 RKK 910
KK
Sbjct: 1102 EKK 1104
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/299 (27%), Positives = 129/299 (43%), Gaps = 43/299 (14%)
Query: 157 YVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEF 216
Y+ + YQK + SEIS G V ++EK ESGWW+V E +GW P+ L V DE
Sbjct: 817 YMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL-----VLDE- 870
Query: 217 SLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEG----WAPA 272
+ QP+ K P R N + +E I++ ++ + K P
Sbjct: 871 NEQPDPSGKELDTVPAKGRQ----NEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPP 926
Query: 273 SYLKKNSGEP------------LPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQ 320
K SG P + P+ SP P +L R+ ++ L +
Sbjct: 927 GGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPP-PKDNNLSCALRRNESLTATDGLRGVR 985
Query: 321 RDGRFEGRPVPDGDAK----QRSPKMRQRPP--PRRDMTIPRGLNLPKPPIPPQ-----V 369
R+ F +AK +R+ P P + +IP PKP Q +
Sbjct: 986 RNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNL 1045
Query: 370 EEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDK----EGWAPATFIDK 424
++ Y +IA+++ + FQ G+ +EV+E+N +GWWY QI D +GW P+ +++K
Sbjct: 1046 KDVYVSIADYEGD-EETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103
Score = 64.7 bits (156), Expect = 4e-10
Identities = 58/218 (26%), Positives = 95/218 (43%), Gaps = 24/218 (11%)
Query: 298 LDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRG 357
+D+ + RQ G +L + + E +P A + +P R +T+P
Sbjct: 745 MDISTLRRQLRPTG---QLRGGLKGSKSEDSELPPQTASE-APSEGSRRSSSDLITLPA- 799
Query: 358 LNLPKPPIPPQVEEE-----YYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIED 412
PP P + E E Y T + +Q ISF AG++V+V+EK SGWWY++ +
Sbjct: 800 ---TTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE 856
Query: 413 KEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALEN--------NTGSEAT 464
EGWAP+ ++ + L +P + Q G++ +LE NT +++
Sbjct: 857 LEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQ-NEGKSDSLEKIERRVQALNTVNQSK 915
Query: 465 GPSRPLPDAPHGVM--DSGLPWSKDWKGSKDVLRKASS 500
+ P+P P G SG P K G + V + S
Sbjct: 916 KATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQS 953
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/166 (25%), Positives = 70/166 (42%), Gaps = 31/166 (18%)
Query: 767 KTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGP 826
K +S + P G EGHE AP + + +P +++G D T + + G
Sbjct: 325 KKASGDKETPPAEG---EGHE---APIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGS 378
Query: 827 WGTGKIGENREKAAAASV------------------PNADGLKDSLYVAVADFEGD-KDT 867
+I R + ++ ++ P + Y +A+F+ D
Sbjct: 379 PAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDG 438
Query: 868 SSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL--RKKP 911
SF+ G EV +KNS GWW+ Q+ EGW P++Y+ RKKP
Sbjct: 439 ISFRGGQKAEVIDKNSGGWWYVQI----GEKEGWAPASYIDKRKKP 480
Score = 45.4 bits (106), Expect = 2e-04
Identities = 24/75 (32%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 834 ENREKAAAASVPNADGLKDSLYVAVADFEGDKDTS-SFQEGTVFEVREKNSSGWWFCQVL 892
E+ +K + A+ + YV V++++ +++ S Q G V +V EKN SGWWF
Sbjct: 150 ESPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFV--- 206
Query: 893 SGAPSWEGWIPSNYL 907
+GW+P+ YL
Sbjct: 207 -STSEEQGWVPATYL 220
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/60 (36%), Positives = 32/60 (53%), Gaps = 5/60 (8%)
Query: 851 KDSLYVAVADFEGD-KDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRK 909
++ YV V + KD F++G EV KN GWW+ + L EGW P++YL+K
Sbjct: 239 EEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGK----EGWAPASYLKK 294
Score = 37.7 bits (86), Expect = 0.049
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 5/54 (9%)
Query: 855 YVAVADFEGDKDTS-SFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL 907
Y+ + ++ +D+ SF G +V EK SGWW+ + EGW PS+YL
Sbjct: 817 YMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRF----GELEGWAPSHYL 866
Score = 37.4 bits (85), Expect = 0.064
Identities = 17/61 (27%), Positives = 33/61 (54%), Gaps = 5/61 (8%)
Query: 223 EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRY----QGKEGWAPASYLKKN 278
++ Y I Y D++ + G +EV+++N GWW + + +GW P++YL+K
Sbjct: 1046 KDVYVSIADYEG-DEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKK 1104
Query: 279 S 279
+
Sbjct: 1105 N 1105
>gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens]
Length = 390
Score = 207 bits (527), Expect = 4e-53
Identities = 133/381 (34%), Positives = 196/381 (51%), Gaps = 37/381 (9%)
Query: 7 IVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQK 66
I + +L +KR VP++HYVY+ V W S + +YRR+++ ++ + + FP+E G
Sbjct: 6 IRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAI 65
Query: 67 DPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRP 126
+P+ RIIP LP F A R + EYC L+ LP IS+C +L FF+ RP
Sbjct: 66 NPENRIIPHLPAPKWFDGQR---AAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRP 122
Query: 127 EDLNPPKEEHIGKKKS-----GGDQTSVD---PMVLEQYVVVANYQKQESSEISLSVGQV 178
+DL P + K ++ G T+ D P++L+ Y +ANY+K SE++LS G V
Sbjct: 123 DDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDV 182
Query: 179 VDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE-EEEKYTVIYPYTARDQ 237
V+++EK+ESGWWF ++GW+PA+ LE D + +P E Y I YTA +
Sbjct: 183 VEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEG 242
Query: 238 DEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPP-----KPG--PG 290
DE++L G VEVI K L+GWW IR G+ P+ YL+K SG+ + K G P
Sbjct: 243 DEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK-SGQDVSQAQRQIKRGAPPR 301
Query: 291 SPSHPGALDLDGVSRQ---QNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPP 347
S A + SR+ Q+A R QR R + RP P SP +R
Sbjct: 302 RSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQR--RRQARPGPQSPG---SPLEEERQT 356
Query: 348 PRRDMTIPRGLNLPKPPIPPQ 368
R + P+P +PP+
Sbjct: 357 QR---------SKPQPAVPPR 368
Score = 65.5 bits (158), Expect = 2e-10
Identities = 54/225 (24%), Positives = 95/225 (42%), Gaps = 25/225 (11%)
Query: 367 PQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYK 426
P + + Y IA ++ T ++ G VEV+EK+ SGWW+ Q++ K GW PA+F++
Sbjct: 155 PIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLD 214
Query: 427 KTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSK 486
P P + + A+E + S G + + H ++D W
Sbjct: 215 SPDETEDPE---PNYAGEPYVAIKAYTAVEGDEVSLLEGEA---VEVIHKLLDG---W-- 263
Query: 487 DWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRT 546
W KD + M +++S + K PPR+ S I++ + +R R+R
Sbjct: 264 -WVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSS-IRNAHSIHQRSRKRLSQ 321
Query: 547 EQLRGPTPK---------PPGVILPMMPAKHIPPARDSRRPEPKP 582
+ R + + PG P P + R ++R +P+P
Sbjct: 322 DAYRRNSVRFLQQRRRQARPG---PQSPGSPLEEERQTQRSKPQP 363
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/54 (40%), Positives = 33/54 (61%), Gaps = 5/54 (9%)
Query: 855 YVAVADFEGDKDTS-SFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL 907
Y A+A++E + + G V EV EK+ SGWWFCQ+ + GWIP+++L
Sbjct: 161 YRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQM----KAKRGWIPASFL 210
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/125 (25%), Positives = 52/125 (41%), Gaps = 14/125 (11%)
Query: 364 PIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFID 423
P P E Y I + D +S G VEVI K L GWW I+ +D G+ P+ ++
Sbjct: 222 PEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281
Query: 424 KYKKTSNASRPNFLAPLP------------HEVTQLRLGEAAALENNTG--SEATGPSRP 469
K + + ++ P H+ ++ RL + A N+ + +RP
Sbjct: 282 KSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARP 341
Query: 470 LPDAP 474
P +P
Sbjct: 342 GPQSP 346
>gi|41281811 NADPH oxidase organizer 1 isoform b [Homo sapiens]
Length = 371
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/271 (23%), Positives = 116/271 (42%), Gaps = 28/271 (10%)
Query: 27 YIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSH 86
+ V WS GS + R + +F L+ + + FP+E G R++P L L R
Sbjct: 24 FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLDAPLLGRVG 83
Query: 87 IRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNP------------PKE 134
+ RL ++ Y + L+ +++ + FF +P DL P P+E
Sbjct: 84 RTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEE 143
Query: 135 EHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSE--ISLSVGQVVDIIEKNESGWWFV 192
+ + + + S+ + + + + Q++ + + +D++ ++ SGWW V
Sbjct: 144 QPLSR---AAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLV 200
Query: 193 STAEEQ-GWVPATCLE------GQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERG 245
+ Q W PA LE G++G S P+ + Y + DE+++ G
Sbjct: 201 ENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQ----FCASRAYESSRADELSVPAG 256
Query: 246 AVVEVIQKNLEGWWKIRYQGKEGWAPASYLK 276
A V V++ + GWW RY + G PA L+
Sbjct: 257 ARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 287
Score = 36.2 bits (82), Expect = 0.14
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 14/99 (14%)
Query: 379 FQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLA 438
++++ D +S AG +V V+E + GWW + D+ G PA + RP L
Sbjct: 243 YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL----------RPEGLG 292
Query: 439 PLPHEVTQLRLGEAAALENN---TGSEATGPSRPLPDAP 474
L T R G+ A E S+AT P +P P
Sbjct: 293 AL-LSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRP 330
Score = 32.7 bits (73), Expect = 1.6
Identities = 12/36 (33%), Positives = 25/36 (69%), Gaps = 1/36 (2%)
Query: 390 QAGLKVEVIEKNLSGWWYIQIEDKE-GWAPATFIDK 424
QA ++V+ ++ SGWW ++ ED++ W PA ++++
Sbjct: 182 QAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEE 217
>gi|41281828 NADPH oxidase organizer 1 isoform c [Homo sapiens]
Length = 376
Score = 83.6 bits (205), Expect = 8e-16
Identities = 64/276 (23%), Positives = 118/276 (42%), Gaps = 33/276 (11%)
Query: 27 YIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKI-----L 81
+ V WS GS + R + +F L+ + + FP+E G R++P L G+ L
Sbjct: 24 FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASLDAPL 83
Query: 82 FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNP---------- 131
R + RL ++ Y + L+ +++ + FF +P DL P
Sbjct: 84 LGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVIL 143
Query: 132 --PKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSE--ISLSVGQVVDIIEKNES 187
P+E+ + + + S+ + + + + Q++ + + +D++ ++ S
Sbjct: 144 PTPEEQPLSR---AAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPS 200
Query: 188 GWWFVSTAEEQ-GWVPATCLE------GQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM 240
GWW V + Q W PA LE G++G S P+ + Y + DE+
Sbjct: 201 GWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQ----FCASRAYESSRADEL 256
Query: 241 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLK 276
++ GA V V++ + GWW RY + G PA L+
Sbjct: 257 SVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 292
Score = 36.2 bits (82), Expect = 0.14
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 14/99 (14%)
Query: 379 FQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLA 438
++++ D +S AG +V V+E + GWW + D+ G PA + RP L
Sbjct: 248 YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL----------RPEGLG 297
Query: 439 PLPHEVTQLRLGEAAALENN---TGSEATGPSRPLPDAP 474
L T R G+ A E S+AT P +P P
Sbjct: 298 AL-LSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRP 335
Score = 32.7 bits (73), Expect = 1.6
Identities = 12/36 (33%), Positives = 25/36 (69%), Gaps = 1/36 (2%)
Query: 390 QAGLKVEVIEKNLSGWWYIQIEDKE-GWAPATFIDK 424
QA ++V+ ++ SGWW ++ ED++ W PA ++++
Sbjct: 187 QAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEE 222
>gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens]
Length = 370
Score = 81.3 bits (199), Expect = 4e-15
Identities = 63/271 (23%), Positives = 116/271 (42%), Gaps = 29/271 (10%)
Query: 27 YIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSH 86
+ V WS GS + R + +F L+ + + FP+E G R++P L L R
Sbjct: 24 FAFSVRWSDGSDTFVRRSWDEFRQLKT-LKETFPVEAGLLRRSDRVLPKLLDAPLLGRVG 82
Query: 87 IRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNP------------PKE 134
+ RL ++ Y + L+ +++ + FF +P DL P P+E
Sbjct: 83 RTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEE 142
Query: 135 EHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSE--ISLSVGQVVDIIEKNESGWWFV 192
+ + + + S+ + + + + Q++ + + +D++ ++ SGWW V
Sbjct: 143 QPLSR---AAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLV 199
Query: 193 STAEEQ-GWVPATCLE------GQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERG 245
+ Q W PA LE G++G S P+ + Y + DE+++ G
Sbjct: 200 ENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQ----FCASRAYESSRADELSVPAG 255
Query: 246 AVVEVIQKNLEGWWKIRYQGKEGWAPASYLK 276
A V V++ + GWW RY + G PA L+
Sbjct: 256 ARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 286
Score = 36.2 bits (82), Expect = 0.14
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 14/99 (14%)
Query: 379 FQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLA 438
++++ D +S AG +V V+E + GWW + D+ G PA + RP L
Sbjct: 242 YESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL----------RPEGLG 291
Query: 439 PLPHEVTQLRLGEAAALENN---TGSEATGPSRPLPDAP 474
L T R G+ A E S+AT P +P P
Sbjct: 292 AL-LSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRP 329
Score = 32.7 bits (73), Expect = 1.6
Identities = 12/36 (33%), Positives = 25/36 (69%), Gaps = 1/36 (2%)
Query: 390 QAGLKVEVIEKNLSGWWYIQIEDKE-GWAPATFIDK 424
QA ++V+ ++ SGWW ++ ED++ W PA ++++
Sbjct: 181 QAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEE 216
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 67.0 bits (162), Expect = 8e-11
Identities = 38/156 (24%), Positives = 75/156 (48%), Gaps = 8/156 (5%)
Query: 126 PEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKN 185
P + PK++ S ++ P + + V + Y S ++SL+ GQ++ I++KN
Sbjct: 1003 PSNYVKPKDQESFGSASKSGASNKKPEIAQ---VTSAYVASGSEQLSLAPGQLILILKKN 1059
Query: 186 ESGWW-----FVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM 240
SGWW ++GW PA+ ++ + + + +Y Y A ++DE+
Sbjct: 1060 TSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDEL 1119
Query: 241 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLK 276
+ +G ++ V+ K+ WW+ G G P++Y+K
Sbjct: 1120 SFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
Score = 55.5 bits (132), Expect = 2e-07
Identities = 53/285 (18%), Positives = 109/285 (38%), Gaps = 31/285 (10%)
Query: 160 VANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLE---GQDGVQDE- 215
+ ++ ++ + ++ S ++ ++E+ E+ WWF +GW P + ++ G + ++E
Sbjct: 879 LCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEP 937
Query: 216 -----------FSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQ 264
S E+Y +YPY++ + ++ G + V QK+ E WW
Sbjct: 938 EALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIG 996
Query: 265 GKEGWAPASYLKKNSGEPLPPKPGPGSPSHP-------GALDLDGVSRQQNAVGREKELL 317
+ G P++Y+K E G+ + A G + A G+ +L
Sbjct: 997 DRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILIL 1056
Query: 318 SSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIA 377
G ++G G +Q+ P + P P + +
Sbjct: 1057 KKNTSGWWQGELQARGKKRQKGWF-----PASHVKLLGPSSERATPAFHPVCQ--VIAMY 1109
Query: 378 EFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
++ D +SF G + V+ K+ WW +I G P+ ++
Sbjct: 1110 DYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYV 1154
Score = 51.6 bits (122), Expect = 3e-06
Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 21/221 (9%)
Query: 213 QDEFSLQPEEEEK--------YTVIYPYTARDQDEMNLERGAVVEVIQKNL--EGWWKIR 262
+D+ +L+ EE+++ Y +YP+ AR+ DEM+ G +++V +K + GW
Sbjct: 714 KDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS 773
Query: 263 YQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRD 322
+QG GW P +Y++K P P + L S + L S+Q
Sbjct: 774 FQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTS------SEPLSSNQPA 827
Query: 323 GRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEE-EYYTIAEFQT 381
+ + V + + ++ R T+ G P VE + + +
Sbjct: 828 SVTDYQNVSFSNLTVNTSWQKKSAFTR---TVSPGSVSPIHGQGQVVENLKAQALCSWTA 884
Query: 382 TIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
+ ++F + V+E+ WW+ ++ GW P +++
Sbjct: 885 KKDNHLNFSKHDIITVLEQQ-ENWWFGEVHGGRGWFPKSYV 924
Score = 42.0 bits (97), Expect = 0.003
Identities = 57/299 (19%), Positives = 107/299 (35%), Gaps = 51/299 (17%)
Query: 153 VLEQYVVVANYQKQESSEISLSVGQVVDIIEKN--ESGWWFVSTAEEQGWVPATCLEGQD 210
VL Y + ++ + E+S + G ++ + EK E GW + S GW P +E
Sbjct: 731 VLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 790
Query: 211 GVQDEFSLQPEEE-EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGW 269
++E ++ P++ TV T+ + ++ + A V Q + W
Sbjct: 791 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTV----NTSW 846
Query: 270 APASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQ---QNAVGREKELLSSQRD---- 322
+K S PG SP H ++ + Q ++ L S+ D
Sbjct: 847 ------QKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV 900
Query: 323 ---------GRFEG----------RPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKP 363
G G + +P + K+ P+ + +N
Sbjct: 901 LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPE-----------ALYAAVNKKPT 949
Query: 364 PIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
V EEY + + + P ++F G ++ V +K+ WW I D+ G P+ ++
Sbjct: 950 SAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKD-GEWWTGSIGDRSGIFPSNYV 1007
Score = 38.1 bits (87), Expect = 0.038
Identities = 31/123 (25%), Positives = 52/123 (42%), Gaps = 20/123 (16%)
Query: 806 PFLSNSLGGQDDTRGKGSL-----GPWGTGKIGE-------------NREKAAAASVPNA 847
P+ S G T G+ L G W TG IG+ ++E +AS A
Sbjct: 964 PYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGA 1023
Query: 848 DGLKDSL-YVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLS-GAPSWEGWIPSN 905
K + V A + S G + + +KN+SGWW ++ + G +GW P++
Sbjct: 1024 SNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPAS 1083
Query: 906 YLR 908
+++
Sbjct: 1084 HVK 1086
Score = 35.8 bits (81), Expect = 0.19
Identities = 17/60 (28%), Positives = 29/60 (48%), Gaps = 2/60 (3%)
Query: 373 YYTIAEFQTTIPDGISFQAGLKVEVIEKNLS--GWWYIQIEDKEGWAPATFIDKYKKTSN 430
Y + F+ D +SF +G ++V EK + GW Y + GW P +++K + N
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSEN 794
Score = 31.6 bits (70), Expect = 3.5
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 7/60 (11%)
Query: 855 YVAVADFEG-DKDTSSFQEGTVFEVREKN--SSGWWFCQVLSGAPSWEGWIPSNYLRKKP 911
Y A+ FE + D SF G + +V EK GW + GW P NY+ K P
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNF----GWFPCNYVEKMP 790
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 67.0 bits (162), Expect = 8e-11
Identities = 38/156 (24%), Positives = 75/156 (48%), Gaps = 8/156 (5%)
Query: 126 PEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKN 185
P + PK++ S ++ P + + V + Y S ++SL+ GQ++ I++KN
Sbjct: 1030 PSNYVKPKDQESFGSASKSGASNKKPEIAQ---VTSAYVASGSEQLSLAPGQLILILKKN 1086
Query: 186 ESGWW-----FVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM 240
SGWW ++GW PA+ ++ + + + +Y Y A ++DE+
Sbjct: 1087 TSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDEL 1146
Query: 241 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLK 276
+ +G ++ V+ K+ WW+ G G P++Y+K
Sbjct: 1147 SFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 55.5 bits (132), Expect = 2e-07
Identities = 53/285 (18%), Positives = 109/285 (38%), Gaps = 31/285 (10%)
Query: 160 VANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLE---GQDGVQDE- 215
+ ++ ++ + ++ S ++ ++E+ E+ WWF +GW P + ++ G + ++E
Sbjct: 906 LCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEP 964
Query: 216 -----------FSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQ 264
S E+Y +YPY++ + ++ G + V QK+ E WW
Sbjct: 965 EALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIG 1023
Query: 265 GKEGWAPASYLKKNSGEPLPPKPGPGSPSHP-------GALDLDGVSRQQNAVGREKELL 317
+ G P++Y+K E G+ + A G + A G+ +L
Sbjct: 1024 DRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILIL 1083
Query: 318 SSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIA 377
G ++G G +Q+ P + P P + +
Sbjct: 1084 KKNTSGWWQGELQARGKKRQKGWF-----PASHVKLLGPSSERATPAFHPVCQ--VIAMY 1136
Query: 378 EFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
++ D +SF G + V+ K+ WW +I G P+ ++
Sbjct: 1137 DYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYV 1181
Score = 51.6 bits (122), Expect = 3e-06
Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 21/221 (9%)
Query: 213 QDEFSLQPEEEEK--------YTVIYPYTARDQDEMNLERGAVVEVIQKNL--EGWWKIR 262
+D+ +L+ EE+++ Y +YP+ AR+ DEM+ G +++V +K + GW
Sbjct: 741 KDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS 800
Query: 263 YQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRD 322
+QG GW P +Y++K P P + L S + L S+Q
Sbjct: 801 FQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTS------SEPLSSNQPA 854
Query: 323 GRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEE-EYYTIAEFQT 381
+ + V + + ++ R T+ G P VE + + +
Sbjct: 855 SVTDYQNVSFSNLTVNTSWQKKSAFTR---TVSPGSVSPIHGQGQVVENLKAQALCSWTA 911
Query: 382 TIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
+ ++F + V+E+ WW+ ++ GW P +++
Sbjct: 912 KKDNHLNFSKHDIITVLEQQ-ENWWFGEVHGGRGWFPKSYV 951
Score = 42.0 bits (97), Expect = 0.003
Identities = 57/299 (19%), Positives = 107/299 (35%), Gaps = 51/299 (17%)
Query: 153 VLEQYVVVANYQKQESSEISLSVGQVVDIIEKN--ESGWWFVSTAEEQGWVPATCLEGQD 210
VL Y + ++ + E+S + G ++ + EK E GW + S GW P +E
Sbjct: 758 VLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 817
Query: 211 GVQDEFSLQPEEE-EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGW 269
++E ++ P++ TV T+ + ++ + A V Q + W
Sbjct: 818 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTV----NTSW 873
Query: 270 APASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQ---QNAVGREKELLSSQRD---- 322
+K S PG SP H ++ + Q ++ L S+ D
Sbjct: 874 ------QKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV 927
Query: 323 ---------GRFEG----------RPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKP 363
G G + +P + K+ P+ + +N
Sbjct: 928 LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPE-----------ALYAAVNKKPT 976
Query: 364 PIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
V EEY + + + P ++F G ++ V +K+ WW I D+ G P+ ++
Sbjct: 977 SAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKD-GEWWTGSIGDRSGIFPSNYV 1034
Score = 38.1 bits (87), Expect = 0.038
Identities = 31/123 (25%), Positives = 52/123 (42%), Gaps = 20/123 (16%)
Query: 806 PFLSNSLGGQDDTRGKGSL-----GPWGTGKIGE-------------NREKAAAASVPNA 847
P+ S G T G+ L G W TG IG+ ++E +AS A
Sbjct: 991 PYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGA 1050
Query: 848 DGLKDSL-YVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLS-GAPSWEGWIPSN 905
K + V A + S G + + +KN+SGWW ++ + G +GW P++
Sbjct: 1051 SNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPAS 1110
Query: 906 YLR 908
+++
Sbjct: 1111 HVK 1113
Score = 35.8 bits (81), Expect = 0.19
Identities = 17/60 (28%), Positives = 29/60 (48%), Gaps = 2/60 (3%)
Query: 373 YYTIAEFQTTIPDGISFQAGLKVEVIEKNLS--GWWYIQIEDKEGWAPATFIDKYKKTSN 430
Y + F+ D +SF +G ++V EK + GW Y + GW P +++K + N
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSEN 821
Score = 31.6 bits (70), Expect = 3.5
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 7/60 (11%)
Query: 855 YVAVADFEG-DKDTSSFQEGTVFEVREKN--SSGWWFCQVLSGAPSWEGWIPSNYLRKKP 911
Y A+ FE + D SF G + +V EK GW + GW P NY+ K P
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNF----GWFPCNYVEKMP 817
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 67.0 bits (162), Expect = 8e-11
Identities = 38/156 (24%), Positives = 75/156 (48%), Gaps = 8/156 (5%)
Query: 126 PEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKN 185
P + PK++ S ++ P + + V + Y S ++SL+ GQ++ I++KN
Sbjct: 1030 PSNYVKPKDQESFGSASKSGASNKKPEIAQ---VTSAYVASGSEQLSLAPGQLILILKKN 1086
Query: 186 ESGWW-----FVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM 240
SGWW ++GW PA+ ++ + + + +Y Y A ++DE+
Sbjct: 1087 TSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDEL 1146
Query: 241 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLK 276
+ +G ++ V+ K+ WW+ G G P++Y+K
Sbjct: 1147 SFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 55.5 bits (132), Expect = 2e-07
Identities = 53/285 (18%), Positives = 109/285 (38%), Gaps = 31/285 (10%)
Query: 160 VANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLE---GQDGVQDE- 215
+ ++ ++ + ++ S ++ ++E+ E+ WWF +GW P + ++ G + ++E
Sbjct: 906 LCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEP 964
Query: 216 -----------FSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQ 264
S E+Y +YPY++ + ++ G + V QK+ E WW
Sbjct: 965 EALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIG 1023
Query: 265 GKEGWAPASYLKKNSGEPLPPKPGPGSPSHP-------GALDLDGVSRQQNAVGREKELL 317
+ G P++Y+K E G+ + A G + A G+ +L
Sbjct: 1024 DRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILIL 1083
Query: 318 SSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIA 377
G ++G G +Q+ P + P P + +
Sbjct: 1084 KKNTSGWWQGELQARGKKRQKGWF-----PASHVKLLGPSSERATPAFHPVCQ--VIAMY 1136
Query: 378 EFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
++ D +SF G + V+ K+ WW +I G P+ ++
Sbjct: 1137 DYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYV 1181
Score = 51.6 bits (122), Expect = 3e-06
Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 21/221 (9%)
Query: 213 QDEFSLQPEEEEK--------YTVIYPYTARDQDEMNLERGAVVEVIQKNL--EGWWKIR 262
+D+ +L+ EE+++ Y +YP+ AR+ DEM+ G +++V +K + GW
Sbjct: 741 KDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS 800
Query: 263 YQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRD 322
+QG GW P +Y++K P P + L S + L S+Q
Sbjct: 801 FQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTS------SEPLSSNQPA 854
Query: 323 GRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEE-EYYTIAEFQT 381
+ + V + + ++ R T+ G P VE + + +
Sbjct: 855 SVTDYQNVSFSNLTVNTSWQKKSAFTR---TVSPGSVSPIHGQGQVVENLKAQALCSWTA 911
Query: 382 TIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
+ ++F + V+E+ WW+ ++ GW P +++
Sbjct: 912 KKDNHLNFSKHDIITVLEQQ-ENWWFGEVHGGRGWFPKSYV 951
Score = 42.0 bits (97), Expect = 0.003
Identities = 57/299 (19%), Positives = 107/299 (35%), Gaps = 51/299 (17%)
Query: 153 VLEQYVVVANYQKQESSEISLSVGQVVDIIEKN--ESGWWFVSTAEEQGWVPATCLEGQD 210
VL Y + ++ + E+S + G ++ + EK E GW + S GW P +E
Sbjct: 758 VLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 817
Query: 211 GVQDEFSLQPEEE-EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGW 269
++E ++ P++ TV T+ + ++ + A V Q + W
Sbjct: 818 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTV----NTSW 873
Query: 270 APASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQ---QNAVGREKELLSSQRD---- 322
+K S PG SP H ++ + Q ++ L S+ D
Sbjct: 874 ------QKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV 927
Query: 323 ---------GRFEG----------RPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKP 363
G G + +P + K+ P+ + +N
Sbjct: 928 LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPE-----------ALYAAVNKKPT 976
Query: 364 PIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
V EEY + + + P ++F G ++ V +K+ WW I D+ G P+ ++
Sbjct: 977 SAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKD-GEWWTGSIGDRSGIFPSNYV 1034
Score = 38.1 bits (87), Expect = 0.038
Identities = 31/123 (25%), Positives = 52/123 (42%), Gaps = 20/123 (16%)
Query: 806 PFLSNSLGGQDDTRGKGSL-----GPWGTGKIGE-------------NREKAAAASVPNA 847
P+ S G T G+ L G W TG IG+ ++E +AS A
Sbjct: 991 PYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGA 1050
Query: 848 DGLKDSL-YVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLS-GAPSWEGWIPSN 905
K + V A + S G + + +KN+SGWW ++ + G +GW P++
Sbjct: 1051 SNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPAS 1110
Query: 906 YLR 908
+++
Sbjct: 1111 HVK 1113
Score = 35.8 bits (81), Expect = 0.19
Identities = 17/60 (28%), Positives = 29/60 (48%), Gaps = 2/60 (3%)
Query: 373 YYTIAEFQTTIPDGISFQAGLKVEVIEKNLS--GWWYIQIEDKEGWAPATFIDKYKKTSN 430
Y + F+ D +SF +G ++V EK + GW Y + GW P +++K + N
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSEN 821
Score = 31.6 bits (70), Expect = 3.5
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 7/60 (11%)
Query: 855 YVAVADFEG-DKDTSSFQEGTVFEVREKN--SSGWWFCQVLSGAPSWEGWIPSNYLRKKP 911
Y A+ FE + D SF G + +V EK GW + GW P NY+ K P
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNF----GWFPCNYVEKMP 817
>gi|47519798 neutrophil cytosolic factor 4 isoform 1 [Homo sapiens]
Length = 339
Score = 66.6 bits (161), Expect = 1e-10
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 10/189 (5%)
Query: 8 VEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKD 67
+ + D++++R H+V++I V GS IYRRY +F LQ ++ ++F + +
Sbjct: 22 ISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPD-SKSS 80
Query: 68 PKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPE 127
+P LP K+ +++A R+ ++ Y K+L+ LP ++ ++V FF P
Sbjct: 81 ALACTLPTLPAKVYVGVK--QEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPY 138
Query: 128 DLNPPKE------EHIGKKKSGGDQ-TSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD 180
D + K KS Q SVD M + + ++ E++ G V+
Sbjct: 139 DSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIF 198
Query: 181 IIEKNESGW 189
++ + W
Sbjct: 199 LLSRINKDW 207
>gi|163644267 neutrophil cytosolic factor 4 isoform 2 [Homo sapiens]
Length = 348
Score = 66.6 bits (161), Expect = 1e-10
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 10/189 (5%)
Query: 8 VEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKD 67
+ + D++++R H+V++I V GS IYRRY +F LQ ++ ++F + +
Sbjct: 22 ISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPD-SKSS 80
Query: 68 PKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPE 127
+P LP K+ +++A R+ ++ Y K+L+ LP ++ ++V FF P
Sbjct: 81 ALACTLPTLPAKVYVGVK--QEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPY 138
Query: 128 DLNPPKE------EHIGKKKSGGDQ-TSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD 180
D + K KS Q SVD M + + ++ E++ G V+
Sbjct: 139 DSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIF 198
Query: 181 IIEKNESGW 189
++ + W
Sbjct: 199 LLSRINKDW 207
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 66.6 bits (161), Expect = 1e-10
Identities = 50/175 (28%), Positives = 75/175 (42%), Gaps = 25/175 (14%)
Query: 142 SGGDQTSVDP------MVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTA 195
S D + VDP + + YV NY + E+SL G V ++EK GWW S
Sbjct: 91 SPADDSFVDPGERLYDLNMPAYVKF-NYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYN 149
Query: 196 EEQGWVPATCL--EGQDGVQDEFSLQPEEEEKYT-------------VIYPYTARDQDEM 240
+ GW P+ + EG + D E+ +YP+++ + +E+
Sbjct: 150 GQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEEL 209
Query: 241 NLERGAVVEVIQK--NLEGWWKIR-YQGKEGWAPASYLKKNSGEPLPPKPGPGSP 292
N E+G V++VI+K N WWK R G G P +Y+ PL P P
Sbjct: 210 NFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPP 264
Score = 56.6 bits (135), Expect = 1e-07
Identities = 39/167 (23%), Positives = 76/167 (45%), Gaps = 39/167 (23%)
Query: 155 EQYVVVA--NYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGV 212
E+ VVVA +Y Q+ E+ + + + +++ ++S W ++ + G+VP+ +E ++
Sbjct: 3 EEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSA 62
Query: 213 Q------------------------------DEFSLQPEEEEKYTVIYP------YTARD 236
+ D+ + P E Y + P Y A
Sbjct: 63 RKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGER-LYDLNMPAYVKFNYMAER 121
Query: 237 QDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPL 283
+DE++L +G V V++K +GWW+ Y G+ GW P++Y+ + PL
Sbjct: 122 EDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPL 168
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/202 (19%), Positives = 78/202 (38%), Gaps = 45/202 (22%)
Query: 222 EEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQ-GKEGWAPASYLKKNSG 280
EE + Y A+ + E+++++ + ++ + + WW++R K G+ P++Y+++ +
Sbjct: 3 EEVVVVAKFDYVAQQEQELDIKKNERLWLLDDS-KSWWRVRNSMNKTGFVPSNYVERKNS 61
Query: 281 EPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSP 340
R+ ++ + +D G+ +R P
Sbjct: 62 ------------------------------ARKASIVKNLKDTLGIGKV-------KRKP 84
Query: 341 KMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEK 400
+ P D + G L +P V+ Y E D +S G KV V+EK
Sbjct: 85 SVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAERE------DELSLIKGTKVIVMEK 138
Query: 401 NLSGWWYIQIEDKEGWAPATFI 422
GWW + GW P+ ++
Sbjct: 139 CSDGWWRGSYNGQVGWFPSNYV 160
Score = 32.3 bits (72), Expect = 2.1
Identities = 18/47 (38%), Positives = 26/47 (55%), Gaps = 6/47 (12%)
Query: 865 KDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWE-GWIPSNYLRKK 910
+D S +GT V EK S GWW G+ + + GW PSNY+ ++
Sbjct: 122 EDELSLIKGTKVIVMEKCSDGWW-----RGSYNGQVGWFPSNYVTEE 163
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/140 (29%), Positives = 70/140 (50%), Gaps = 15/140 (10%)
Query: 7 IVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEA--IYRRYSKFFDLQMQMLDKFPMEGG 64
I EV V K+ P+KHY+Y++R+ G E ++R + +F +L ++ FP+
Sbjct: 1424 IKEVSVFTYHKKYNPDKHYIYVVRIL-REGQIEPSFVFRTFDEFQELHNKLSIIFPLWK- 1481
Query: 65 QKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFET 124
+P P +++ R+HI+DVA KR I ++ Y ++L+ +++CD V FF
Sbjct: 1482 --------LPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHP 1533
Query: 125 RPEDLNPPKEEHIGKKKSGG 144
L K E I + G
Sbjct: 1534 L---LRDEKAEGIARSADAG 1550
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 65.9 bits (159), Expect = 2e-10
Identities = 144/699 (20%), Positives = 240/699 (34%), Gaps = 151/699 (21%)
Query: 156 QYVVVANYQKQESSEISLSVGQVVDIIEKNES-GWWFVSTAEEQGWVPATC-------LE 207
+ +V+A Y+ Q+ E+SL+ G VV + + GW G P L
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLR 61
Query: 208 GQDGVQ--------DEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWW 259
G + + P + V + Y+ DE+ L+ G +VE+I++ +GWW
Sbjct: 62 GSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWW 121
Query: 260 KIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSS 319
+ G+ G P+++++ P P G+P P
Sbjct: 122 LGKKNGQLGAFPSNFVELLDSGP----PSLGNPDMPSV---------------------- 155
Query: 320 QRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEF 379
P P QRPP + + + P+V Y + ++
Sbjct: 156 --------SPGP------------QRPPKLSSLAYDSPPDYLQTVSHPEV---YRVLFDY 192
Query: 380 QTTIPDGISFQAGLKVEVIEKNL--SGWWYIQIEDKEGWAPATF------IDKYKKTSNA 431
Q PD ++ + G V+V+ K GWW + + + G P F I K
Sbjct: 193 QPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRKVV 252
Query: 432 SRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGS 491
SR + AP+ E +L + + TGPS+ S P S
Sbjct: 253 SRES--API-KEPKKLMPKTSLPTVKKLATATTGPSK--------AKTSRTP-------S 294
Query: 492 KDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRG 551
+D + S D + G++ P RK S ++ + +E + + ++
Sbjct: 295 RDSQKLTSRDSGPNGGFQSGGSYH-------PGRKRSKTQTPQQRSVSSQEEEHSSPVKA 347
Query: 552 P----TPKPPGVILPMMP--AKHIPPARDSRRPE--PKPDKSRLFQLKNDM-GLECGHKV 602
P TP P P P ++ P ++ P+ P P+K+ K + G K+
Sbjct: 348 PSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKI 407
Query: 603 LAKE-VKKPNLRPISKSKTDLPE-----------EKPDATPQNPF-LKSRPQVRPKP--- 646
A + V P + K +PE +KP +TP+ F ++ P + P
Sbjct: 408 PAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKP-STPERVFSVEESPALEAPPMDK 466
Query: 647 APSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGP 706
P+PK P E A + +K L + V +D F E
Sbjct: 467 VPNPKMAPLGDE--------------APTLEKVLTPELSEEEVSTRDDIQFHHFSSEEAL 512
Query: 707 GRAQDRTGKQDGLSPKEISC--RAPPRP---------AKTTDPVSKSVP--VPLQEAPQQ 753
+ + K+D S +E PP+P K T S P L+ P
Sbjct: 513 QKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPAS 572
Query: 754 RPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAP 792
RP + P T P + R P+ E + P
Sbjct: 573 RPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRP 611
Score = 45.4 bits (106), Expect = 2e-04
Identities = 119/552 (21%), Positives = 207/552 (37%), Gaps = 74/552 (13%)
Query: 155 EQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGV-Q 213
E Y V+ +YQ + E++L G VV ++ K T E++GW C +G+ GV
Sbjct: 184 EVYRVLFDYQPEAPDELALRRGDVVKVLSK---------TTEDKGWWEGEC-QGRRGVFP 233
Query: 214 DEFSLQPEEEEKYT---VIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWA 270
D F L P +K V+ +A ++ L + ++K L + K
Sbjct: 234 DNFVLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKK-LATATTGPSKAKTSRT 292
Query: 271 PASYLKKNSGEPLPPKPG--PGSPSHPGALDLDGVSRQQNAV-GREKELLSSQRDGRFEG 327
P+ +K + P G G HPG + QQ +V +E+E S + +
Sbjct: 293 PSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKR 352
Query: 328 RPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGI 387
P+PD A P + P + + P K P P E+ T+ + + +IP
Sbjct: 353 TPMPDKTATPERPPAPENAPSSKKIPAP-----DKVPSP----EKTLTLGD-KASIPGN- 401
Query: 388 SFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQL 447
K+ +K + + EDK + I ++T +P+ P V +
Sbjct: 402 --STSGKIPAPDKVPTPEKMVTPEDKASIPENSIIP--EETLTVDKPS----TPERVFSV 453
Query: 448 RLGEAAALENNTGSEATGPS-RPLPDAPHGVMDSGLPWSKDWK------------GSKDV 494
E+ ALE + P PL D + P + + S++
Sbjct: 454 E--ESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEA 511
Query: 495 LRKASSDMSAS--AGYEEISDPDMEEKPSLPPRKESII-KSEGELLERERERQRTEQLRG 551
L+K ++ + EE P E P PP E + + + L+ + ++ E G
Sbjct: 512 LQKVKYFVAKEDPSSQEEAHTP--EAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSG 569
Query: 552 PTPKP------PGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDM----GLECGHK 601
P +P P +P + P+ D R PE + + L+ ++ G+ +
Sbjct: 570 PASRPALEKPHPHEEATTLPEE--APSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEE 627
Query: 602 VLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRP---QVRPKPAPSPKTEPPQGE 658
V KE P K + P E+ A P +K P + P+ P+
Sbjct: 628 VTLKEELPPKEEVAPKEEVP-PIERAFAQKTRP-IKPPPDSQETLALPSLVPQNYTENKN 685
Query: 659 DQVDICNLRSKL 670
+ VD+ +LR ++
Sbjct: 686 EGVDVTSLRGEV 697
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 65.9 bits (159), Expect = 2e-10
Identities = 112/568 (19%), Positives = 195/568 (34%), Gaps = 127/568 (22%)
Query: 158 VVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEG------QDG 211
+V +YQ Q E+++SVG+++ I K + GWW +G P + +D
Sbjct: 5 IVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDP 64
Query: 212 VQDEFSLQPEEE------------------------EKYTVIYPYTARDQDEMNLERGAV 247
+ ++ +P E + V + Y ++ DE+ L+ G +
Sbjct: 65 LTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDI 124
Query: 248 VEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQ 307
+EV+ + EGWW+ GK G P++++K+ SGE + G L + +
Sbjct: 125 IEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGE--SDELGISQDEQLSKSSLRETTGSE 182
Query: 308 NAVGREKELLSSQRDGRF--------EGRPVPDGDA-KQRSPKMRQRPPPRRDMTIP--- 355
+ G S +G + + V GD K + K+R R + +P
Sbjct: 183 SDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEK 242
Query: 356 -RGLNLPKPPIPP-----------QVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNL- 402
G LP P + ++ I ++ D ++ + G V +I K+
Sbjct: 243 TIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCI 302
Query: 403 -SGWWYIQIEDKEGWAPATFI----DKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALEN 457
GWW ++ + G P F+ ++K N RP P P ++ G A E
Sbjct: 303 DVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN--RPK--KPPPPSAPVIKQG-AGTTER 357
Query: 458 NTGSEATGPSRP--LPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPD 515
+ P RP LP+ K + ++ S P
Sbjct: 358 KHEIKKIPPERPEMLPNRTE--------------------EKERPEREPKLDLQKPSVPA 397
Query: 516 MEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDS 575
+ K PP+ S+ + PG + P P + + P +
Sbjct: 398 IPPKKPRPPKTNSLSR-------------------------PGALPPRRPERPVGPLTHT 432
Query: 576 RRPEPKPD----------KSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEE 625
R PK D L ND+ LE V++ K L + S+
Sbjct: 433 RGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEK---LSHPTTSRPKATGR 489
Query: 626 KPDATPQNPFLKSRPQVRPKPAPSPKTE 653
+P + S P + P+P E
Sbjct: 490 RPPSQSLTSSSLSSPDIFDSPSPEEDKE 517
Score = 48.9 bits (115), Expect = 2e-05
Identities = 119/589 (20%), Positives = 198/589 (33%), Gaps = 139/589 (23%)
Query: 228 VIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYL----KKNSGEPL 283
V + Y A+ DE+ + G ++ I+K GWW+ + G+ G P +++ K+ +PL
Sbjct: 6 VEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPL 65
Query: 284 PPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMR 343
K P P H V LLSS+ R R G+ ++R ++
Sbjct: 66 TNK-APEKPLHE--------------VPSGNSLLSSETILRTNKR----GERRRRRCQVA 106
Query: 344 QRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLS 403
P+ D D + + G +EV+ +
Sbjct: 107 FSYLPQND---------------------------------DELELKVGDIIEVVGEVEE 133
Query: 404 GWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEA 463
GWW + K G P+ FI + S+ ++Q ++L TGSE+
Sbjct: 134 GWWEGVLNGKTGMFPSNFIKELSGESDELG----------ISQDEQLSKSSLRETTGSES 183
Query: 464 TG--PSRPLPDAPHGVMDSGLPWSKDWKGS------KD------------------VLRK 497
G S + +G + + K KG KD V +
Sbjct: 184 DGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKT 243
Query: 498 ASSDMSASAGYEEISDPDMEEK-----------PSLPPRKESIIKSEGELLER-ERERQR 545
+ A+ + S +M+ + P + + EG+++ ++
Sbjct: 244 IGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCID 303
Query: 546 TEQLRGPTPKPPGVILPMMPAKHIPP--ARDSRRPEPKPDKSRLFQLKNDMGLECGHKVL 603
G GV P K +PP ++ RP+ P S + E H++
Sbjct: 304 VGWWEGELNGRRGVF-PDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIK 362
Query: 604 AKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDI 663
++P + P + + PE +P Q P + + P +P+P PKT
Sbjct: 363 KIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRP---PKTN---------- 409
Query: 664 CNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQ-DGLSPK 722
S RP + GP + G+ P D G G+ K
Sbjct: 410 ----SLSRPGALPPRRPERPVGPL-----------THTRGDSP--KIDLAGSSLSGILDK 452
Query: 723 EISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSS 771
++S R+ + D V S L RP RRPP TSSS
Sbjct: 453 DLSDRSNDIDLEGFDSVVSSTE-KLSHPTTSRPKATGRRPPSQSLTSSS 500
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 64.3 bits (155), Expect = 5e-10
Identities = 37/132 (28%), Positives = 63/132 (47%), Gaps = 16/132 (12%)
Query: 159 VVANYQKQESSEISLSVGQVVDIIEKNESGWW-----FVSTAEEQGWVPATCLEGQDGVQ 213
V+A+Y +++L+ GQ++ I +KN GWW + GW PA ++
Sbjct: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT 1140
Query: 214 DEFSLQPEEEEKYTVI---------YPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQ 264
+ + P E K T + Y YTA++ DE+ +G ++ V+ K WWK
Sbjct: 1141 SKIT--PTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 265 GKEGWAPASYLK 276
G+ G P++Y+K
Sbjct: 1199 GQVGLFPSNYVK 1210
Score = 62.4 bits (150), Expect = 2e-09
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 12/153 (7%)
Query: 155 EQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD---- 210
E+++ + Y+ E +++ G V+ ++ K + WW + ++ G P+ + +D
Sbjct: 1005 EEFIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGS 1063
Query: 211 GVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWW--KIRYQGKE- 267
G + ++ E VI YTA +++ L G ++ + +KN GWW +++ +GK+
Sbjct: 1064 GTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKR 1123
Query: 268 --GWAPASYLKKNSGEPLPPKPGPGSPSHPGAL 298
GW PA+Y+K S P K P P AL
Sbjct: 1124 QIGWFPANYVKLLS--PGTSKITPTEPPKSTAL 1154
Score = 54.3 bits (129), Expect = 5e-07
Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 37/222 (16%)
Query: 229 IYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPG 288
+YP+ A+ + +N + V+ V+++ + WW QG++GW P SY+K SG P+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQ-DMWWFGEVQGQKGWFPKSYVKLISG-PIRKSTS 978
Query: 289 --PGSPSHPGALDLDGVSRQQNAVGREK---------------------ELLSSQRDGRF 325
GS P +L + V E+ +L +++DG +
Sbjct: 979 MDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDW 1038
Query: 326 EGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPD 385
V D S +R + G +L K P QV IA + T P+
Sbjct: 1039 WTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTG-SLGKKPEIAQV------IASYTATGPE 1091
Query: 386 GISFQAGLKVEVIEKNLSGWWYIQIEDKE-----GWAPATFI 422
++ G + + +KN GWW +++ + GW PA ++
Sbjct: 1092 QLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV 1133
Score = 50.1 bits (118), Expect = 1e-05
Identities = 53/299 (17%), Positives = 116/299 (38%), Gaps = 52/299 (17%)
Query: 163 YQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDG-VQDEFSLQPE 221
++ ++ + ++ + V+ ++E+ + WWF ++GW P + ++ G ++ S+
Sbjct: 924 WRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSG 982
Query: 222 EE--------------------EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKI 261
E++ +Y Y + +Q ++ ++G V+ V +K+ + WW
Sbjct: 983 SSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTG 1041
Query: 262 RYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGAL----DLDGVSRQQNAVGREKELL 317
K G P++Y++ E G G+ G+L ++ V A G E+ L
Sbjct: 1042 TVGDKAGVFPSNYVRLKDSE------GSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTL 1095
Query: 318 S---------SQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQ 368
+ G +EG G +Q P + G + P PP+
Sbjct: 1096 APGQLILIRKKNPGGWWEGELQARGKKRQIG-----WFPANYVKLLSPGTSKITPTEPPK 1150
Query: 369 VEE-----EYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
+ + ++ D ++F G + V+ K WW ++ + G P+ ++
Sbjct: 1151 STALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYV 1209
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/227 (22%), Positives = 88/227 (38%), Gaps = 35/227 (15%)
Query: 226 YTVIYPYTARDQDEMNLERGAVVEV-------IQKNLEGWWKIRYQGKEGWAPASYLKK- 277
Y +YP+ +R DE+ ++ G +V V Q GW +GK GW PA+Y +K
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804
Query: 278 -NSGEPLPPKPGPGSPSHPG--------ALDLDGVSRQQNAVGREKELLSSQRDGRFEGR 328
+ P P KP S S P L S + + SS +
Sbjct: 805 PENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEK 864
Query: 329 PVPDG-DAKQRSP--------KMRQRPPPRRDMTIPRGLNLPKPPIPPQVEE----EYYT 375
P D DA P ++RQR T P+ Q E+ +
Sbjct: 865 PETDNWDAWAAQPSLTVPSAGQLRQRSA----FTPATATGSSPSPVLGQGEKVEGLQAQA 920
Query: 376 IAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
+ ++ + ++F + V+E+ WW+ +++ ++GW P +++
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQ-DMWWFGEVQGQKGWFPKSYV 966
Score = 37.4 bits (85), Expect = 0.064
Identities = 23/99 (23%), Positives = 42/99 (42%), Gaps = 15/99 (15%)
Query: 825 GPWGTGKIGE-------------NREKAAAASVPNADGLKDSLYVAVADFEGD-KDTSSF 870
G W TG +G+ + E + A + G K + +A + + +
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTL 1095
Query: 871 QEGTVFEVREKNSSGWWFCQVLS-GAPSWEGWIPSNYLR 908
G + +R+KN GWW ++ + G GW P+NY++
Sbjct: 1096 APGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
Score = 33.1 bits (74), Expect = 1.2
Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 21/95 (22%)
Query: 826 PWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEG-DKDTSSFQEGTVFEVREKNSS 884
PW T + G ++ + +K Y A+ FE D + Q G + V+
Sbjct: 723 PWSTAEKGP-------LTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVK----- 770
Query: 885 GWWFCQVLSGAPSW--------EGWIPSNYLRKKP 911
G W + +G P W GW P+NY K P
Sbjct: 771 GEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Score = 32.3 bits (72), Expect = 2.1
Identities = 11/48 (22%), Positives = 25/48 (52%)
Query: 156 QYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPA 203
Q + + +Y Q E++ + GQ+++++ K + WW + G P+
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPS 1206
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 64.3 bits (155), Expect = 5e-10
Identities = 37/132 (28%), Positives = 63/132 (47%), Gaps = 16/132 (12%)
Query: 159 VVANYQKQESSEISLSVGQVVDIIEKNESGWW-----FVSTAEEQGWVPATCLEGQDGVQ 213
V+A+Y +++L+ GQ++ I +KN GWW + GW PA ++
Sbjct: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT 1140
Query: 214 DEFSLQPEEEEKYTVI---------YPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQ 264
+ + P E K T + Y YTA++ DE+ +G ++ V+ K WWK
Sbjct: 1141 SKIT--PTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 265 GKEGWAPASYLK 276
G+ G P++Y+K
Sbjct: 1199 GQVGLFPSNYVK 1210
Score = 62.4 bits (150), Expect = 2e-09
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 12/153 (7%)
Query: 155 EQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD---- 210
E+++ + Y+ E +++ G V+ ++ K + WW + ++ G P+ + +D
Sbjct: 1005 EEFIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGS 1063
Query: 211 GVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWW--KIRYQGKE- 267
G + ++ E VI YTA +++ L G ++ + +KN GWW +++ +GK+
Sbjct: 1064 GTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKR 1123
Query: 268 --GWAPASYLKKNSGEPLPPKPGPGSPSHPGAL 298
GW PA+Y+K S P K P P AL
Sbjct: 1124 QIGWFPANYVKLLS--PGTSKITPTEPPKSTAL 1154
Score = 54.3 bits (129), Expect = 5e-07
Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 37/222 (16%)
Query: 229 IYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPG 288
+YP+ A+ + +N + V+ V+++ + WW QG++GW P SY+K SG P+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQ-DMWWFGEVQGQKGWFPKSYVKLISG-PIRKSTS 978
Query: 289 --PGSPSHPGALDLDGVSRQQNAVGREK---------------------ELLSSQRDGRF 325
GS P +L + V E+ +L +++DG +
Sbjct: 979 MDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDW 1038
Query: 326 EGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPD 385
V D S +R + G +L K P QV IA + T P+
Sbjct: 1039 WTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTG-SLGKKPEIAQV------IASYTATGPE 1091
Query: 386 GISFQAGLKVEVIEKNLSGWWYIQIEDKE-----GWAPATFI 422
++ G + + +KN GWW +++ + GW PA ++
Sbjct: 1092 QLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV 1133
Score = 50.1 bits (118), Expect = 1e-05
Identities = 53/299 (17%), Positives = 116/299 (38%), Gaps = 52/299 (17%)
Query: 163 YQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDG-VQDEFSLQPE 221
++ ++ + ++ + V+ ++E+ + WWF ++GW P + ++ G ++ S+
Sbjct: 924 WRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSG 982
Query: 222 EE--------------------EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKI 261
E++ +Y Y + +Q ++ ++G V+ V +K+ + WW
Sbjct: 983 SSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTG 1041
Query: 262 RYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGAL----DLDGVSRQQNAVGREKELL 317
K G P++Y++ E G G+ G+L ++ V A G E+ L
Sbjct: 1042 TVGDKAGVFPSNYVRLKDSE------GSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTL 1095
Query: 318 S---------SQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQ 368
+ G +EG G +Q P + G + P PP+
Sbjct: 1096 APGQLILIRKKNPGGWWEGELQARGKKRQIG-----WFPANYVKLLSPGTSKITPTEPPK 1150
Query: 369 VEE-----EYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
+ + ++ D ++F G + V+ K WW ++ + G P+ ++
Sbjct: 1151 STALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYV 1209
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/227 (22%), Positives = 88/227 (38%), Gaps = 35/227 (15%)
Query: 226 YTVIYPYTARDQDEMNLERGAVVEV-------IQKNLEGWWKIRYQGKEGWAPASYLKK- 277
Y +YP+ +R DE+ ++ G +V V Q GW +GK GW PA+Y +K
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804
Query: 278 -NSGEPLPPKPGPGSPSHPG--------ALDLDGVSRQQNAVGREKELLSSQRDGRFEGR 328
+ P P KP S S P L S + + SS +
Sbjct: 805 PENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEK 864
Query: 329 PVPDG-DAKQRSP--------KMRQRPPPRRDMTIPRGLNLPKPPIPPQVEE----EYYT 375
P D DA P ++RQR T P+ Q E+ +
Sbjct: 865 PETDNWDAWAAQPSLTVPSAGQLRQRSA----FTPATATGSSPSPVLGQGEKVEGLQAQA 920
Query: 376 IAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFI 422
+ ++ + ++F + V+E+ WW+ +++ ++GW P +++
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQ-DMWWFGEVQGQKGWFPKSYV 966
Score = 37.4 bits (85), Expect = 0.064
Identities = 23/99 (23%), Positives = 42/99 (42%), Gaps = 15/99 (15%)
Query: 825 GPWGTGKIGE-------------NREKAAAASVPNADGLKDSLYVAVADFEGD-KDTSSF 870
G W TG +G+ + E + A + G K + +A + + +
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTL 1095
Query: 871 QEGTVFEVREKNSSGWWFCQVLS-GAPSWEGWIPSNYLR 908
G + +R+KN GWW ++ + G GW P+NY++
Sbjct: 1096 APGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
Score = 35.0 bits (79), Expect = 0.32
Identities = 24/110 (21%), Positives = 49/110 (44%), Gaps = 11/110 (10%)
Query: 156 QYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLE---GQDGV 212
Q + + +Y Q E++ + GQ+++++ K + WW + G P+ ++ D
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPS 1218
Query: 213 QDEFS-------LQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNL 255
Q S L P E ++ I+ +++ +N + V E+ QK L
Sbjct: 1219 QQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVN-DLQLVTEIFQKPL 1267
Score = 33.1 bits (74), Expect = 1.2
Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 21/95 (22%)
Query: 826 PWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEG-DKDTSSFQEGTVFEVREKNSS 884
PW T + G ++ + +K Y A+ FE D + Q G + V+
Sbjct: 723 PWSTAEKGP-------LTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVK----- 770
Query: 885 GWWFCQVLSGAPSW--------EGWIPSNYLRKKP 911
G W + +G P W GW P+NY K P
Sbjct: 771 GEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 60.8 bits (146), Expect = 5e-09
Identities = 54/209 (25%), Positives = 86/209 (41%), Gaps = 25/209 (11%)
Query: 123 ETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDII 182
+T D +P +G + + + +V A Y + E+SL G V ++
Sbjct: 83 KTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFA-YVAEREDELSLVKGSRVTVM 141
Query: 183 EKNESGWWFVSTAEEQGWVPAT-CLEGQDGVQDE----------FSLQPEEEEK----YT 227
EK GWW S + GW P+ LE D E SL + +
Sbjct: 142 EKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQ 201
Query: 228 VIYPYTARDQDEMNLERGAVVEVIQK--NLEGWWKIR-YQGKEGWAPASYLKKNSGEPLP 284
+YP+++ ++E+N E+G +EVI+K N WWK + +G+ G P +Y+ S P
Sbjct: 202 TLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPAL 261
Query: 285 PKPGPGSPSHPGALDLDGVSRQQNAVGRE 313
P+H + G S GRE
Sbjct: 262 ------HPAHAPQISYTGPSSSGRFAGRE 284
Score = 45.8 bits (107), Expect = 2e-04
Identities = 53/233 (22%), Positives = 94/233 (40%), Gaps = 50/233 (21%)
Query: 230 YPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG-KEGWAPASYLKKNSGEPLPPKPG 288
+ YTA+ E+++++ + ++ + + WW++R + G+ P++Y+++ + K G
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDS-KTWWRVRNAANRTGYVPSNYVERKNSL----KKG 65
Query: 289 PGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPP 348
+ L L R+ +A RD P P DA+ P
Sbjct: 66 SLVKNLKDTLGLGKTRRKTSA-----------RDAS----PTPSTDAEY----------P 100
Query: 349 RRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYI 408
R +L IP V+ Y E D +S G +V V+EK GWW
Sbjct: 101 ANGSGADRIYDLN---IPAFVKFAYVAERE------DELSLVKGSRVTVMEKCSDGWWRG 151
Query: 409 QIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGS 461
+ GW P+ ++ + + A P+FL+ L + A+L N GS
Sbjct: 152 SYNGQIGWFPSNYVLEEVDEAAAESPSFLS----------LRKGASLSNGQGS 194
Score = 31.2 bits (69), Expect = 4.6
Identities = 17/44 (38%), Positives = 24/44 (54%), Gaps = 6/44 (13%)
Query: 865 KDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWE-GWIPSNYL 907
+D S +G+ V EK S GWW G+ + + GW PSNY+
Sbjct: 127 EDELSLVKGSRVTVMEKCSDGWW-----RGSYNGQIGWFPSNYV 165
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 60.8 bits (146), Expect = 5e-09
Identities = 54/209 (25%), Positives = 86/209 (41%), Gaps = 25/209 (11%)
Query: 123 ETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDII 182
+T D +P +G + + + +V A Y + E+SL G V ++
Sbjct: 83 KTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFA-YVAEREDELSLVKGSRVTVM 141
Query: 183 EKNESGWWFVSTAEEQGWVPAT-CLEGQDGVQDE----------FSLQPEEEEK----YT 227
EK GWW S + GW P+ LE D E SL + +
Sbjct: 142 EKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQ 201
Query: 228 VIYPYTARDQDEMNLERGAVVEVIQK--NLEGWWKIR-YQGKEGWAPASYLKKNSGEPLP 284
+YP+++ ++E+N E+G +EVI+K N WWK + +G+ G P +Y+ S P
Sbjct: 202 TLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPAL 261
Query: 285 PKPGPGSPSHPGALDLDGVSRQQNAVGRE 313
P+H + G S GRE
Sbjct: 262 ------HPAHAPQISYTGPSSSGRFAGRE 284
Score = 45.8 bits (107), Expect = 2e-04
Identities = 53/233 (22%), Positives = 94/233 (40%), Gaps = 50/233 (21%)
Query: 230 YPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG-KEGWAPASYLKKNSGEPLPPKPG 288
+ YTA+ E+++++ + ++ + + WW++R + G+ P++Y+++ + K G
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDS-KTWWRVRNAANRTGYVPSNYVERKNSL----KKG 65
Query: 289 PGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPP 348
+ L L R+ +A RD P P DA+ P
Sbjct: 66 SLVKNLKDTLGLGKTRRKTSA-----------RDAS----PTPSTDAEY----------P 100
Query: 349 RRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYI 408
R +L IP V+ Y E D +S G +V V+EK GWW
Sbjct: 101 ANGSGADRIYDLN---IPAFVKFAYVAERE------DELSLVKGSRVTVMEKCSDGWWRG 151
Query: 409 QIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGS 461
+ GW P+ ++ + + A P+FL+ L + A+L N GS
Sbjct: 152 SYNGQIGWFPSNYVLEEVDEAAAESPSFLS----------LRKGASLSNGQGS 194
Score = 31.2 bits (69), Expect = 4.6
Identities = 17/44 (38%), Positives = 24/44 (54%), Gaps = 6/44 (13%)
Query: 865 KDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWE-GWIPSNYL 907
+D S +G+ V EK S GWW G+ + + GW PSNY+
Sbjct: 127 EDELSLVKGSRVTVMEKCSDGWW-----RGSYNGQIGWFPSNYV 165
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 58.5 bits (140), Expect = 3e-08
Identities = 22/54 (40%), Positives = 37/54 (68%)
Query: 224 EKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK 277
++Y +Y YTA++ DE++L G ++EVI + +GWW + G+ G+ P SYL+K
Sbjct: 362 QEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEK 415
Score = 46.2 bits (108), Expect = 1e-04
Identities = 18/53 (33%), Positives = 32/53 (60%)
Query: 155 EQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLE 207
++Y + +Y Q E+ LS G ++++I + E GWW V ++G+VP + LE
Sbjct: 362 QEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLE 414
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/175 (19%), Positives = 63/175 (36%), Gaps = 21/175 (12%)
Query: 251 IQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAV 310
I +++ + + + G E AP Y E P PG G +
Sbjct: 261 IDADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLTSSPGIQPSCGMI------------ 308
Query: 311 GREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPK-PPIPPQV 369
+ G G P A + P P R+ + + + + P
Sbjct: 309 --------KRFSGLLHGSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASP 360
Query: 370 EEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDK 424
+EY + ++ PD + AG +EVI + GWW ++ + G+ P ++++K
Sbjct: 361 AQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEK 415
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 57.0 bits (136), Expect = 8e-08
Identities = 50/164 (30%), Positives = 71/164 (43%), Gaps = 15/164 (9%)
Query: 145 DQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPAT 204
++ DP+ LE YV A K S +++ GW S+AEEQ
Sbjct: 1015 EERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGW---SSAEEQ------ 1065
Query: 205 CLEGQDGVQDEFSLQPEE--EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIR 262
+ D +D L P++ KYTV+ + D + + G VVE++Q+ EG W +R
Sbjct: 1066 -INSSDAEEDG-GLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVR 1123
Query: 263 --YQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVS 304
GKEGW PAS L G + S S PG+ L S
Sbjct: 1124 DPTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSS 1167
Score = 37.7 bits (86), Expect = 0.049
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 369 VEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQ--IEDKEGWAPAT 420
V +Y +A+ + PD + ++G VE++++ G WY++ KEGW PA+
Sbjct: 1083 VPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPAS 1136
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 57.0 bits (136), Expect = 8e-08
Identities = 50/164 (30%), Positives = 71/164 (43%), Gaps = 15/164 (9%)
Query: 145 DQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPAT 204
++ DP+ LE YV A K S +++ GW S+AEEQ
Sbjct: 962 EERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGW---SSAEEQ------ 1012
Query: 205 CLEGQDGVQDEFSLQPEE--EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIR 262
+ D +D L P++ KYTV+ + D + + G VVE++Q+ EG W +R
Sbjct: 1013 -INSSDAEEDG-GLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVR 1070
Query: 263 --YQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVS 304
GKEGW PAS L G + S S PG+ L S
Sbjct: 1071 DPTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSS 1114
Score = 37.7 bits (86), Expect = 0.049
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 369 VEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQ--IEDKEGWAPAT 420
V +Y +A+ + PD + ++G VE++++ G WY++ KEGW PA+
Sbjct: 1030 VPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPAS 1083
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 57.0 bits (136), Expect = 8e-08
Identities = 116/550 (21%), Positives = 189/550 (34%), Gaps = 78/550 (14%)
Query: 279 SGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEG-RPVPD-GDAK 336
S +P P +PGP PS S+Q + + S + + +PV G K
Sbjct: 506 STKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGK 565
Query: 337 QR-----SPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQA 391
SP +Q P TI N + + + + T E QTT+ F
Sbjct: 566 PLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNP 625
Query: 392 GLKVEVIEKNLSGWWYIQIEDKEGW----APATFIDKYK-KTSNASRPNFLAPLPHEVTQ 446
+ +++ W + + K AP + K KT+ + + ++ + Q
Sbjct: 626 NPHLTEVKE----WLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQ 681
Query: 447 LRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASA 506
+ AA + + S+A P +P P + D L K + S
Sbjct: 682 TSPKKDAAPKQDL-SKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSV 740
Query: 507 GYEEISDPDMEEKPSLP----PRKESIIKSEGEL--------LERERERQRTEQLRGPTP 554
E+ P ++KP P P + + S ++ + E + T L+ +
Sbjct: 741 PSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800
Query: 555 KPPGVILPM------MPAKHIP-PARDSR---RPEPKPDKSRLFQLKNDMGLECGHKVLA 604
KP P +K IP PA DS+ P P + Q+ E K
Sbjct: 801 KPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQT 860
Query: 605 KEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKP--------------APSP 650
K KP+ +P+ K P +P A P PQ PKP +P
Sbjct: 861 KMSPKPDAKPMPKGSPTPPGPRPTAGQTVP----TPQQSPKPQEQSRRFSLNLGSITDAP 916
Query: 651 KTEPPQGEDQVD--ICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGR 708
K++P ++ V + + + S S GP + G ++ P + P
Sbjct: 917 KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPP-- 974
Query: 709 AQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQE--------APQQRPVVPPR 760
P + + +APP PAK+ PV K P E AP + +
Sbjct: 975 --------TSQGPPKSTGQAPPAPAKSI-PVKKETKAPAAEKLEPKAEQAPTVKRTETEK 1025
Query: 761 RPPPPKKTSS 770
+PPP K + S
Sbjct: 1026 KPPPIKDSKS 1035
Score = 47.4 bits (111), Expect = 6e-05
Identities = 95/407 (23%), Positives = 144/407 (35%), Gaps = 71/407 (17%)
Query: 483 PWSKDWKGSKDVLRKASSDMSASAGYEEI--SDPDMEEKPSLPPRKESIIKSEGELLERE 540
P K +D L++ + S S+ E S P KP P + L+R+
Sbjct: 218 PIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRD 277
Query: 541 RERQRTEQ---LRGPTPKP--PGVILP--MMPAKHIPPAR----DSRRPEPKPDKSRLFQ 589
R +T+Q +RG + KP P P P PPA+ + +P P ++
Sbjct: 278 ASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSG 337
Query: 590 LKNDMGLECGH---KVLAKEVKKPNLRPISKSKTDLPE---EKPD-------ATPQNPFL 636
L + + G V KP +P+ +K + EKP A Q P +
Sbjct: 338 LTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV 397
Query: 637 KSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAF 696
P +P PA P + + L+S + A K+ + GP + Q
Sbjct: 398 GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAK-APGPTKTPVQQPGPGKIPAQQA-- 454
Query: 697 SRSFLPGEGPGRAQ-DRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRP 755
GPG+ +TG P ++ P PAK P P Q P + P
Sbjct: 455 --------GPGKTSAQQTGPTK--PPSQL-----PGPAK---------PPPQQPGPAKPP 490
Query: 756 VVPPRRPPPPKKTSSSSRPLPEVRG-----PQCEGHESRAAPTPGRA---LLVPPKAKPF 807
P PP + S++P P+ G PQ G + PG A P AKP
Sbjct: 491 PQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPS 550
Query: 808 LSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSL 854
S T G+GK + + +A P + GL ++
Sbjct: 551 AQQSTKPVSQT---------GSGKPLQPPTVSPSAKQPPSQGLPKTI 588
Score = 46.2 bits (108), Expect = 1e-04
Identities = 56/242 (23%), Positives = 93/242 (38%), Gaps = 38/242 (15%)
Query: 550 RGPTPKPPGVILPMMPAKHIPPARDSRRP-------EPKPDKSRLFQLKNDMGLECGHKV 602
+ P PK P ++ P H P+ +++P +P P K + D K
Sbjct: 696 KAPEPKKPPPLVKQ-PTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKP 754
Query: 603 LAKEVKKPNLRPISKS----KTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGE 658
++ KP +S S K D+P K + + K+ P ++ A ++ PP GE
Sbjct: 755 KQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEE---KTTPPLKTDSAKPSQSFPPTGE 811
Query: 659 DQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQ-DRTGKQD 717
+ SK P + D ++ GP + E G+ Q D K++
Sbjct: 812 K---VSPFDSKAIPRPASDSKIISHPGPSS---------------ESKGQKQVDPVQKKE 853
Query: 718 GLSPKEISCRAPPRP-AKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLP 776
PK+ + P+P AK S + P P A Q P P + P P +++ S L
Sbjct: 854 --EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPT-PQQSPKPQEQSRRFSLNLG 910
Query: 777 EV 778
+
Sbjct: 911 SI 912
Score = 43.9 bits (102), Expect = 7e-04
Identities = 68/268 (25%), Positives = 104/268 (38%), Gaps = 36/268 (13%)
Query: 552 PTPKPPGVILPMMPAKHIPP-ARDSRRPE---PKPDKSRLFQLKNDMGLECGHKVLAKEV 607
P P P L P ++ S +P+ PK D + K D+ K V
Sbjct: 652 PVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAP----KQDLSKAPEPKKPPPLV 707
Query: 608 KKPNLRPISKSKTDLPEE-----KPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVD 662
K+P L +K P E KP A P+ P + S P PK +P + D
Sbjct: 708 KQPTLHGSPSAKAKQPPEADSLSKP-APPKEPSVPSEQDKAPVADDKPK-QPKMVKPTTD 765
Query: 663 ICNLRS---KLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGL 719
+ + S K S+ +S + + + S+SF P TG++ +
Sbjct: 766 LVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPP----------TGEK--V 813
Query: 720 SPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVR 779
SP +A PRPA + +S P P E+ Q+ V P ++ PKK + P P+ +
Sbjct: 814 SP--FDSKAIPRPASDSKIISH--PGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAK 869
Query: 780 GPQCEGHESRAAPTPGRALLVP-PKAKP 806
P +G + P P VP P+ P
Sbjct: 870 -PMPKGSPTPPGPRPTAGQTVPTPQQSP 896
Score = 33.9 bits (76), Expect = 0.71
Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 2/76 (2%)
Query: 700 FLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSV-PVPLQEAPQQRPVVP 758
F GE G+ + + G SP S A PRP + + S P P P P P
Sbjct: 2361 FTSGETFGQEKPASQLPSG-SPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPP 2419
Query: 759 PRRPPPPKKTSSSSRP 774
P PPPP +S +P
Sbjct: 2420 PPPPPPPLPPPTSPKP 2435
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 57.0 bits (136), Expect = 8e-08
Identities = 116/550 (21%), Positives = 189/550 (34%), Gaps = 78/550 (14%)
Query: 279 SGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEG-RPVPD-GDAK 336
S +P P +PGP PS S+Q + + S + + +PV G K
Sbjct: 506 STKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGK 565
Query: 337 QR-----SPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQA 391
SP +Q P TI N + + + + T E QTT+ F
Sbjct: 566 PLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNP 625
Query: 392 GLKVEVIEKNLSGWWYIQIEDKEGW----APATFIDKYK-KTSNASRPNFLAPLPHEVTQ 446
+ +++ W + + K AP + K KT+ + + ++ + Q
Sbjct: 626 NPHLTEVKE----WLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQ 681
Query: 447 LRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASA 506
+ AA + + S+A P +P P + D L K + S
Sbjct: 682 TSPKKDAAPKQDL-SKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSV 740
Query: 507 GYEEISDPDMEEKPSLP----PRKESIIKSEGEL--------LERERERQRTEQLRGPTP 554
E+ P ++KP P P + + S ++ + E + T L+ +
Sbjct: 741 PSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800
Query: 555 KPPGVILPM------MPAKHIP-PARDSR---RPEPKPDKSRLFQLKNDMGLECGHKVLA 604
KP P +K IP PA DS+ P P + Q+ E K
Sbjct: 801 KPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQT 860
Query: 605 KEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKP--------------APSP 650
K KP+ +P+ K P +P A P PQ PKP +P
Sbjct: 861 KMSPKPDAKPMPKGSPTPPGPRPTAGQTVP----TPQQSPKPQEQSRRFSLNLGSITDAP 916
Query: 651 KTEPPQGEDQVD--ICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGR 708
K++P ++ V + + + S S GP + G ++ P + P
Sbjct: 917 KSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPP-- 974
Query: 709 AQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQE--------APQQRPVVPPR 760
P + + +APP PAK+ PV K P E AP + +
Sbjct: 975 --------TSQGPPKSTGQAPPAPAKSI-PVKKETKAPAAEKLEPKAEQAPTVKRTETEK 1025
Query: 761 RPPPPKKTSS 770
+PPP K + S
Sbjct: 1026 KPPPIKDSKS 1035
Score = 47.4 bits (111), Expect = 6e-05
Identities = 95/407 (23%), Positives = 144/407 (35%), Gaps = 71/407 (17%)
Query: 483 PWSKDWKGSKDVLRKASSDMSASAGYEEI--SDPDMEEKPSLPPRKESIIKSEGELLERE 540
P K +D L++ + S S+ E S P KP P + L+R+
Sbjct: 218 PIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRD 277
Query: 541 RERQRTEQ---LRGPTPKP--PGVILP--MMPAKHIPPAR----DSRRPEPKPDKSRLFQ 589
R +T+Q +RG + KP P P P PPA+ + +P P ++
Sbjct: 278 ASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSG 337
Query: 590 LKNDMGLECGH---KVLAKEVKKPNLRPISKSKTDLPE---EKPD-------ATPQNPFL 636
L + + G V KP +P+ +K + EKP A Q P +
Sbjct: 338 LTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV 397
Query: 637 KSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAF 696
P +P PA P + + L+S + A K+ + GP + Q
Sbjct: 398 GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAK-APGPTKTPVQQPGPGKIPAQQA-- 454
Query: 697 SRSFLPGEGPGRAQ-DRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRP 755
GPG+ +TG P ++ P PAK P P Q P + P
Sbjct: 455 --------GPGKTSAQQTGPTK--PPSQL-----PGPAK---------PPPQQPGPAKPP 490
Query: 756 VVPPRRPPPPKKTSSSSRPLPEVRG-----PQCEGHESRAAPTPGRA---LLVPPKAKPF 807
P PP + S++P P+ G PQ G + PG A P AKP
Sbjct: 491 PQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPS 550
Query: 808 LSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSL 854
S T G+GK + + +A P + GL ++
Sbjct: 551 AQQSTKPVSQT---------GSGKPLQPPTVSPSAKQPPSQGLPKTI 588
Score = 46.2 bits (108), Expect = 1e-04
Identities = 56/242 (23%), Positives = 93/242 (38%), Gaps = 38/242 (15%)
Query: 550 RGPTPKPPGVILPMMPAKHIPPARDSRRP-------EPKPDKSRLFQLKNDMGLECGHKV 602
+ P PK P ++ P H P+ +++P +P P K + D K
Sbjct: 696 KAPEPKKPPPLVKQ-PTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKP 754
Query: 603 LAKEVKKPNLRPISKS----KTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGE 658
++ KP +S S K D+P K + + K+ P ++ A ++ PP GE
Sbjct: 755 KQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEE---KTTPPLKTDSAKPSQSFPPTGE 811
Query: 659 DQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQ-DRTGKQD 717
+ SK P + D ++ GP + E G+ Q D K++
Sbjct: 812 K---VSPFDSKAIPRPASDSKIISHPGPSS---------------ESKGQKQVDPVQKKE 853
Query: 718 GLSPKEISCRAPPRP-AKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLP 776
PK+ + P+P AK S + P P A Q P P + P P +++ S L
Sbjct: 854 --EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPT-PQQSPKPQEQSRRFSLNLG 910
Query: 777 EV 778
+
Sbjct: 911 SI 912
Score = 43.9 bits (102), Expect = 7e-04
Identities = 68/268 (25%), Positives = 104/268 (38%), Gaps = 36/268 (13%)
Query: 552 PTPKPPGVILPMMPAKHIPP-ARDSRRPE---PKPDKSRLFQLKNDMGLECGHKVLAKEV 607
P P P L P ++ S +P+ PK D + K D+ K V
Sbjct: 652 PVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAP----KQDLSKAPEPKKPPPLV 707
Query: 608 KKPNLRPISKSKTDLPEE-----KPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVD 662
K+P L +K P E KP A P+ P + S P PK +P + D
Sbjct: 708 KQPTLHGSPSAKAKQPPEADSLSKP-APPKEPSVPSEQDKAPVADDKPK-QPKMVKPTTD 765
Query: 663 ICNLRS---KLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGL 719
+ + S K S+ +S + + + S+SF P TG++ +
Sbjct: 766 LVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPP----------TGEK--V 813
Query: 720 SPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVR 779
SP +A PRPA + +S P P E+ Q+ V P ++ PKK + P P+ +
Sbjct: 814 SP--FDSKAIPRPASDSKIISH--PGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAK 869
Query: 780 GPQCEGHESRAAPTPGRALLVP-PKAKP 806
P +G + P P VP P+ P
Sbjct: 870 -PMPKGSPTPPGPRPTAGQTVPTPQQSP 896
Score = 33.9 bits (76), Expect = 0.71
Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 2/76 (2%)
Query: 700 FLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSV-PVPLQEAPQQRPVVP 758
F GE G+ + + G SP S A PRP + + S P P P P P
Sbjct: 2361 FTSGETFGQEKPASQLPSG-SPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPP 2419
Query: 759 PRRPPPPKKTSSSSRP 774
P PPPP +S +P
Sbjct: 2420 PPPPPPPLPPPTSPKP 2435
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 55.8 bits (133), Expect = 2e-07
Identities = 45/186 (24%), Positives = 83/186 (44%), Gaps = 24/186 (12%)
Query: 201 VPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNL--EGW 258
+PAT D + E + + ++ VI+PY A++ DE+ ++ G +V +I K+ GW
Sbjct: 211 LPATTAT-PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGW 269
Query: 259 WKIRYQGKEGWAPASYLK-------KNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVG 311
W+ G+ G P +++K K P P P PS P G + +++ +
Sbjct: 270 WEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPP----PSAPVIKQGAGTTERKHEIK 325
Query: 312 R----EKELLSSQRDGRFEGRPVPDGDAKQRS----PKMRQRPPPRRDMTIPRGL--NLP 361
+ E+L ++ + + P D ++ S P + RPP ++ P L P
Sbjct: 326 KIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRP 385
Query: 362 KPPIPP 367
+ P+ P
Sbjct: 386 ERPVGP 391
Score = 50.4 bits (119), Expect = 7e-06
Identities = 94/468 (20%), Positives = 160/468 (34%), Gaps = 97/468 (20%)
Query: 228 VIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKP 287
V + Y ++ DE+ L+ G ++EV+ + EGWW+ GK G P++++K+ SGE +
Sbjct: 68 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGE--SDEL 125
Query: 288 GPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRF--------EGRPVPDGDA-KQR 338
G L + ++ G S +G + + V GD K +
Sbjct: 126 GISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDK 185
Query: 339 SPKMRQRPPPRRDMTIP----RGLNLPKPPIPP-----------QVEEEYYTIAEFQTTI 383
K+R R + +P G LP P + ++ I ++
Sbjct: 186 PIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQN 245
Query: 384 PDGISFQAGLKVEVIEKNL--SGWWYIQIEDKEGWAPATFI----DKYKKTSNASRPNFL 437
D ++ + G V +I K+ GWW ++ + G P F+ ++K N RP
Sbjct: 246 DDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN--RPK-- 301
Query: 438 APLPHEVTQLRLGEAAALENNTGSEATGPSRP--LPDAPHGVMDSGLPWSKDWKGSKDVL 495
P P ++ G A E + P RP LP+
Sbjct: 302 KPPPPSAPVIKQG-AGTTERKHEIKKIPPERPEMLPNRTE-------------------- 340
Query: 496 RKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPK 555
K + ++ S P + K PP+ S+ +
Sbjct: 341 EKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSR------------------------ 376
Query: 556 PPGVILPMMPAKHIPPARDSRRPEPKPD----------KSRLFQLKNDMGLECGHKVLAK 605
PG + P P + + P +R PK D L ND+ LE V++
Sbjct: 377 -PGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSS 435
Query: 606 EVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTE 653
K L + S+ +P + S P + P+P E
Sbjct: 436 TEK---LSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKE 480
Score = 43.1 bits (100), Expect = 0.001
Identities = 19/80 (23%), Positives = 37/80 (46%)
Query: 159 VVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSL 218
V +Y Q E+ L VG +++++ + E GWW + G P+ ++ G DE +
Sbjct: 68 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGI 127
Query: 219 QPEEEEKYTVIYPYTARDQD 238
+E+ + + T + D
Sbjct: 128 SQDEQLSKSSLRETTGSESD 147
Score = 35.4 bits (80), Expect = 0.24
Identities = 87/428 (20%), Positives = 144/428 (33%), Gaps = 83/428 (19%)
Query: 385 DGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEV 444
D + + G +EV+ + GWW + K G P+ FI + S+ +
Sbjct: 78 DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELG----------I 127
Query: 445 TQLRLGEAAALENNTGSEATG--PSRPLPDAPHGVMDSGLPWSKDWKGS------KD--- 493
+Q ++L TGSE+ G S + +G + + K KG KD
Sbjct: 128 SQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPI 187
Query: 494 ---------------VLRKASSDMSASAGYEEISDPDMEEK-----------PSLPPRKE 527
V + + A+ + S +M+ + P +
Sbjct: 188 KLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDD 247
Query: 528 SIIKSEGELLER-ERERQRTEQLRGPTPKPPGVILPMMPAKHIPP--ARDSRRPEPKPDK 584
+ EG+++ ++ G GV P K +PP ++ RP+ P
Sbjct: 248 ELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVF-PDNFVKLLPPDFEKEGNRPKKPPPP 306
Query: 585 SRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRP 644
S + E H++ ++P + P + + PE +P Q P + + P +P
Sbjct: 307 SAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKP 366
Query: 645 KPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGE 704
+P PKT S RP + GP + G+
Sbjct: 367 RP---PKTN--------------SLSRPGALPPRRPERPVGPL-----------THTRGD 398
Query: 705 GPGRAQDRTGKQ-DGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPP 763
P D G G+ K++S R+ + D V S L RP RRPP
Sbjct: 399 SP--KIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTE-KLSHPTTSRPKATGRRPP 455
Query: 764 PPKKTSSS 771
TSSS
Sbjct: 456 SQSLTSSS 463
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 55.8 bits (133), Expect = 2e-07
Identities = 28/76 (36%), Positives = 43/76 (56%), Gaps = 7/76 (9%)
Query: 226 YTVIYPYTARDQDEMNLERGAVVEVIQKNL-----EGWWKIRYQGKEGWAPASYLK--KN 278
+ +Y Y AR +DE++L RG +VEV+ ++ EGWW + Q + G PA+Y+ +
Sbjct: 43 WAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRP 102
Query: 279 SGEPLPPKPGPGSPSH 294
+ P PP P SP H
Sbjct: 103 AASPAPPPSRPSSPVH 118
>gi|150417989 cyclin K isoform 1 [Homo sapiens]
Length = 580
Score = 55.5 bits (132), Expect = 2e-07
Identities = 72/290 (24%), Positives = 104/290 (35%), Gaps = 41/290 (14%)
Query: 544 QRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVL 603
Q+++ + P P P PA+ PA+ ++P P+P R Q+K + + +
Sbjct: 289 QQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPR--QVKRAVVVSPKEENK 346
Query: 604 AKEVKKPNLRPISKSKTDLPEEKP-------------DATPQNPFLKS---RPQVRPKPA 647
A E P + I + LP P +A P P + + Q+ P
Sbjct: 347 AAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAH 406
Query: 648 PSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPG 707
P+P +PP + S S S + GEG Q++ +S + EGP
Sbjct: 407 PAPVHQPPPLPHRPP-PPPPSSYMTGMSTTSSYMSGEGYQSL--------QSMMKTEGP- 456
Query: 708 RAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRP--PPP 765
L P P P PVP A P +PP P PPP
Sbjct: 457 -------SYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPP 509
Query: 766 KKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQ 815
T + + P P R P H P PG L PP + P + GGQ
Sbjct: 510 PPTYNPNFPPPPPRLPPT--HAVPPHPPPGLGL--PPASYPPPAVPPGGQ 555
>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
1 [Homo sapiens]
Length = 1250
Score = 54.7 bits (130), Expect = 4e-07
Identities = 66/271 (24%), Positives = 96/271 (35%), Gaps = 18/271 (6%)
Query: 552 PTPK-PPGVILPMMPAKHIPPARDSRR---PEPKPDKSRLFQLKNDMG----LECGHKVL 603
PTP PP P PA +IPP+ + P P K + F K + K +
Sbjct: 806 PTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI 865
Query: 604 AKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPK--PAPSPKTEPPQGEDQV 661
A + P P +S+ P A P +K++P+ +P P PSP PP E +
Sbjct: 866 ASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSL 925
Query: 662 DICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSP 721
PA P G S++ PG G+ T +++
Sbjct: 926 VFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPG---GKKPPPTPQRNSSIK 982
Query: 722 KEISCRAP-PRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG 780
P P+ VSK P +P + + PP PP P K + S LP V
Sbjct: 983 SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
Query: 781 PQCEGHESRAAPTPGRALLV----PPKAKPF 807
C ++ G+ +V PP F
Sbjct: 1043 QGCVSAKAPVLSGRGKDSVVEFPSPPSDSDF 1073
Score = 34.3 bits (77), Expect = 0.54
Identities = 39/167 (23%), Positives = 55/167 (32%), Gaps = 24/167 (14%)
Query: 640 PQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRS 699
P P PAP P PP+ + + P +Q P + AF S
Sbjct: 764 PPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTP-PVPPAKKQPAFPAS 822
Query: 700 FLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPP 759
++P P P + PP K +K P PL P +
Sbjct: 823 YIPPSPP------------TPPVPVP---PPTLPKQQSFCAKPPPSPLSPVPSVVKQIAS 867
Query: 760 RRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKP 806
+ PPPP + S+PL V + AP A+ PK +P
Sbjct: 868 QFPPPPTPPAMESQPLKPV--------PANVAPQSPPAVKAKPKWQP 906
Score = 33.9 bits (76), Expect = 0.71
Identities = 30/91 (32%), Positives = 37/91 (40%), Gaps = 21/91 (23%)
Query: 279 SGEPLPPKPGPGSPSHPGALDLDGVS----RQQNAVGREKELLSSQRDGRFEGRPVPDGD 334
S E LPP P +P PG L+L GV+ QQ V + +LS + P P D
Sbjct: 1014 SKETLPP---PAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSD 1070
Query: 335 AKQRSPKMRQRPPPRRDMTIPRGLNLPKPPI 365
+ PPP P LP PPI
Sbjct: 1071 S--------DFPPP------PPETELPLPPI 1087
Score = 32.7 bits (73), Expect = 1.6
Identities = 64/283 (22%), Positives = 97/283 (34%), Gaps = 58/283 (20%)
Query: 544 QRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVL 603
Q Q+ PTP PP P +PA +PP + PKP L + + V+
Sbjct: 753 QHITQVAPPTPPPP----PPIPAP-LPP-----QAPPKP----LVTIPAPTSTKTVAPVV 798
Query: 604 AKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDI 663
+ P+ P +K A P + ++ P P P P PP Q
Sbjct: 799 TQAAPPTPTPPVP------PAKKQPAFPAS-YIPPSPPTPPVPVP-----PPTLPKQQSF 846
Query: 664 CNLR--SKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSP 721
C S L P S K + + F P P + + K P
Sbjct: 847 CAKPPPSPLSPVPSVVKQI----------------ASQFPPPPTPPAMESQPLKP---VP 887
Query: 722 KEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRP----VVPPR----RPPPPKKTSSSSR 773
++ ++PP S+PVP + P P V PP P PP ++
Sbjct: 888 ANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTAS 947
Query: 774 PLPEVRGPQCEGHESRAAPTPGRALLVP-PKAKPFLSNSLGGQ 815
P P+ G G ++ +PG P P+ + +S G +
Sbjct: 948 PTPDKSG--SPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAE 988
Score = 32.0 bits (71), Expect = 2.7
Identities = 25/90 (27%), Positives = 31/90 (34%), Gaps = 4/90 (4%)
Query: 730 PRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHES- 788
P+P T + PL P P PP PPPP S S P P + +
Sbjct: 611 PQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTI 670
Query: 789 ---RAAPTPGRALLVPPKAKPFLSNSLGGQ 815
+ A AL PP S S+ Q
Sbjct: 671 TRLQNASQHSGALFKPPTPPVMQSQSVKPQ 700
Score = 31.2 bits (69), Expect = 4.6
Identities = 43/194 (22%), Positives = 58/194 (29%), Gaps = 20/194 (10%)
Query: 614 PISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDIC---NLRSKL 670
P + S+ P P P P P P P P P P + + ++L
Sbjct: 618 PYTASQPSPPLPPPPPPPPPP----PPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRL 673
Query: 671 RPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPP 730
+ A +L P + Q V P G +P + P
Sbjct: 674 QNASQHSGALFKPPTPPVMQSQSVKPQILVPPN---GVVPPPPPPPPPPTPGSAMAQLKP 730
Query: 731 RPAKTTDPVSKSVPVPLQEAPQQR--PVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHES 788
P + P + P PL+ Q V PP PPPP P+P PQ
Sbjct: 731 APCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP--------PIPAPLPPQAPPKPL 782
Query: 789 RAAPTPGRALLVPP 802
P P V P
Sbjct: 783 VTIPAPTSTKTVAP 796
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 53.5 bits (127), Expect = 9e-07
Identities = 81/349 (23%), Positives = 132/349 (37%), Gaps = 54/349 (15%)
Query: 512 SDPDMEEKPSLPPRKESIIK---SEGELLERERERQRTEQLRGP--TPKPPGVILPMMPA 566
+ P E+ P+ PP ++S++ E LL E Q + GP +P+P L P
Sbjct: 698 TSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPE 757
Query: 567 K-HIPPARDSRRPEPKPDKSRLFQLKNDMGL----ECGHKV-------LAKEVKKPNLRP 614
+ H+ P + P+P++ L + + L E H L+ + ++P+L P
Sbjct: 758 EPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSP 817
Query: 615 ISKSKTDLPE-EKPDATPQN--PFLKSRPQVR------PKPAPSPKTE-PPQGEDQVDIC 664
+ + P+ E+ +PQ+ P L RP+ KP SP+ E PP+ Q
Sbjct: 818 VPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAP 877
Query: 665 NLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEI 724
P S L GE + G+ S LP E P L P +
Sbjct: 878 EELPLFPPPGEPSLSPLLGEPALSEPGEPPL---SPLPEELPLSPSGEPSLSPQLMPPD- 933
Query: 725 SCRAPPRPAKTTDPVSKSVPVPLQ-----------------EAPQQRPVVPPRRPPPPKK 767
P P + ++ + P L E+P P++ PPP+
Sbjct: 934 -----PLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEA 988
Query: 768 TSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQD 816
+ P+P + P G A +P +PP+ P L +SL Q+
Sbjct: 989 NCTDPEPVPPMILPPSPGSPVGPA-SPILMEPLPPQCSPLLQHSLVPQN 1036
Score = 47.4 bits (111), Expect = 6e-05
Identities = 73/316 (23%), Positives = 113/316 (35%), Gaps = 66/316 (20%)
Query: 510 EISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILP--MMPAK 567
++ P EE P LPP +ES + E E P P+ + P +PA
Sbjct: 429 QLEAPLNEEMPLLPPPEESPLSPPPE-----------ESPTSPPPEASRLSPPPEELPAS 477
Query: 568 HIPPARDSRRP------EPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTD 621
+P A RP P P++S L + + P P S +
Sbjct: 478 PLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFS---PLEESPLSPPEESPPSPALET 534
Query: 622 LPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLL 681
P+A+P +P + P + P P P + PP+ S+L P ++S +
Sbjct: 535 PLSPPPEASPLSPPFEESP-LSPPPEELPTSPPPEA----------SRLSP--PPEESPM 581
Query: 682 DGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS--PKEISCRAPPRPAKTTDPV 739
++ SR F P E + LS P+E PP ++ + P
Sbjct: 582 SPPPEESPMSPPPEASRLFPPFE-----------ESPLSPPPEESPLSPPPEASRLSPPP 630
Query: 740 SKSVPVPLQEAPQQRPVVPP-------------RRPPPPKKTSSSSRPLPEVRGPQCEGH 786
S P+ P++ P+ PP R PPP+++ S P P E
Sbjct: 631 EDS---PMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEA- 686
Query: 787 ESRAAPTPGRALLVPP 802
SR +P P + PP
Sbjct: 687 -SRLSPPPEDSPTSPP 701
Score = 45.8 bits (107), Expect = 2e-04
Identities = 79/318 (24%), Positives = 110/318 (34%), Gaps = 34/318 (10%)
Query: 514 PDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPAR 573
P EE P+ PP + S + E E E P P+ + P + PP
Sbjct: 556 PPPEELPTSPPPEASRLSPPPE--ESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPE 613
Query: 574 DSRRPEPKPDKSRLFQLKNDMGL----ECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDA 629
+S P P+ SRL D + E EV + + P+ + PEE P +
Sbjct: 614 ESPL-SPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLS 672
Query: 630 TPQNPFLKSRP----QVRPKPAPSPKTEPPQG-------EDQVDICNL-RSKLRPAKSQD 677
P S P ++ P P SP + PP+ ED + L S L P +
Sbjct: 673 PPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEP 732
Query: 678 KSLLDGEGPQAVGGQDVAF--SRSFLPGEGPGRAQDRTGKQDGLSPKE-ISCRAPPRP-- 732
+ EGP + R P P + Q P+E C P P
Sbjct: 733 QLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQ----PEEPCLCAVPEEPHL 788
Query: 733 -AKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAA 791
+ P P L +PQ P P P++ S +P PQ E E +
Sbjct: 789 SPQAEGPHLSPQPEELHLSPQTE---EPHLSPVPEEPCLSPQPEESHLSPQSE--EPCLS 843
Query: 792 PTPGRALLVPPKAKPFLS 809
P P + L P KP LS
Sbjct: 844 PRPEESHLSPELEKPPLS 861
Score = 39.7 bits (91), Expect = 0.013
Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 24/122 (19%)
Query: 708 RAQDRTGKQDGLSPKE---ISCRAPPR-------PAKTTDPVSKSVPV-------PLQEA 750
+ Q + G + PKE + C A P + P+++ +P+ PL
Sbjct: 393 QGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPP 452
Query: 751 PQQRPVVPP----RRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRA-LLVPPKAK 805
P++ P PP R PPP++ +S PLPE ES +P P + L PP++
Sbjct: 453 PEESPTSPPPEASRLSPPPEELPAS--PLPEALHLSRPLEESPLSPPPEESPLSPPPESS 510
Query: 806 PF 807
PF
Sbjct: 511 PF 512
Score = 38.9 bits (89), Expect = 0.022
Identities = 26/93 (27%), Positives = 37/93 (39%), Gaps = 6/93 (6%)
Query: 702 PGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRR 761
P P T L +++S P P+ P++ S P E + P P
Sbjct: 4884 PAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAE 4943
Query: 762 PPPPK-----KTSSSSRPLPEVRGPQCEGHESR 789
PP P + S+RP P R P+ EG +SR
Sbjct: 4944 PPVPSPLPLASSPESARPKPRARPPE-EGEDSR 4975
Score = 33.5 bits (75), Expect = 0.93
Identities = 27/90 (30%), Positives = 34/90 (37%), Gaps = 5/90 (5%)
Query: 721 PKEISCRAPPRPAKTTDPVSKSVPV-PLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVR 779
P E S +PP P +S P PL+E+P + PP PP + P PE
Sbjct: 488 PLEESPLSPPPEESPLSPPPESSPFSPLEESP----LSPPEESPPSPALETPLSPPPEAS 543
Query: 780 GPQCEGHESRAAPTPGRALLVPPKAKPFLS 809
ES +P P PP LS
Sbjct: 544 PLSPPFEESPLSPPPEELPTSPPPEASRLS 573
Score = 32.7 bits (73), Expect = 1.6
Identities = 25/86 (29%), Positives = 36/86 (41%), Gaps = 12/86 (13%)
Query: 720 SPKEISCRAPPR-PAK--TTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLP 776
SP E+ + PP+ PA+ + DP + PL+ + P PP PP P T + ++P
Sbjct: 2155 SPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEP---RFPTAPPTYPPYPSPTGAPAQP-- 2209
Query: 777 EVRGPQCEGHESRAAPTPGRALLVPP 802
P A PG PP
Sbjct: 2210 ----PMLGASSRPGAGQPGEFHTTPP 2231
Score = 31.6 bits (70), Expect = 3.5
Identities = 57/279 (20%), Positives = 85/279 (30%), Gaps = 28/279 (10%)
Query: 510 EISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHI 569
E+ PD+ + P L PR + L R +E + L P P + P
Sbjct: 2320 ELKTPDVFKAP-LTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPY 2378
Query: 570 PPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDA 629
+ RP+P P +S A + P S+ +
Sbjct: 2379 AQPPLTPRPQPPPPES----------------CCALPPRSLPSDPFSRVPASPQSQSSSQ 2422
Query: 630 TPQNPFLKSRPQVRPKP------APSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDG 683
+P P S P P +P P + PP D +P + Q +
Sbjct: 2423 SPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRD--PFAPLHKPPRPQPPEVAFK 2480
Query: 684 EGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSV 743
G A + LP G + G P + T P+ +
Sbjct: 2481 AGSLAHTSLGAGGFPAALPAGPAGELHAKV--PSGQPPNFVRSPGTGAFVGTPSPMRFTF 2538
Query: 744 PVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQ 782
P + E P +P VP PPP +S P P + PQ
Sbjct: 2539 PQAVGE-PSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQ 2576
Score = 31.6 bits (70), Expect = 3.5
Identities = 56/199 (28%), Positives = 75/199 (37%), Gaps = 29/199 (14%)
Query: 610 PNLRPISKSKTD-LPEEKPDATPQNPFLKSRPQV---------RPKPAPSPKTEPPQGED 659
P L P S D L P ATP + + SR V P P P + Q
Sbjct: 2759 PILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLW 2818
Query: 660 QVDICNLRSKLRPAKSQDKSLLDGE--GPQAVGGQDVAFSRSFLPGEG---PGRA----- 709
Q + +R A S G G QA+G S LPG G PG A
Sbjct: 2819 QQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGISTR-LPGPGEPVPGPAGPAQF 2877
Query: 710 -QDRTGKQDGLSP--KEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPV--VPPRRP-- 762
+ R Q GL P + PP+ + PVS+ E + V +PP++P
Sbjct: 2878 IELRHNVQKGLGPGGTPFPGQGPPQRPRFY-PVSEDPHRLAPEGLRGLAVSGLPPQKPSA 2936
Query: 763 PPPKKTSSSSRPLPEVRGP 781
PP + ++S P P +GP
Sbjct: 2937 PPAPELNNSLHPTPHTKGP 2955
Score = 30.4 bits (67), Expect = 7.8
Identities = 38/136 (27%), Positives = 48/136 (35%), Gaps = 19/136 (13%)
Query: 721 PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRP------PPPKKTSSSSRP 774
P E C PPR + +DP S+ P ++ Q P+ P RP P T P
Sbjct: 2391 PPESCCALPPR-SLPSDPFSRVPASPQSQSSSQSPLTP--RPLSAEAFCPSPVTPRFQSP 2447
Query: 775 LPEVRGPQCEGHESRAAPTPGRALLVPPKAKP----FLSNSLGGQDDTRGKGSLGPWGTG 830
P R P AP L PP+ +P F + SL G G G
Sbjct: 2448 DPYSRPPSRPQSRDPFAP-----LHKPPRPQPPEVAFKAGSLAHTSLGAG-GFPAALPAG 2501
Query: 831 KIGENREKAAAASVPN 846
GE K + PN
Sbjct: 2502 PAGELHAKVPSGQPPN 2517
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 53.1 bits (126), Expect = 1e-06
Identities = 115/543 (21%), Positives = 165/543 (30%), Gaps = 110/543 (20%)
Query: 284 PPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMR 343
PP+ P P H R+ + R + S+ G + + P R
Sbjct: 328 PPRRMPPPPRH----------RRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKR 377
Query: 344 QRPPPRRDMTI------PRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEV 397
PPR+ + PR + P PP P + + + P + +V V
Sbjct: 378 TSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRH-------SPTPQQSNRTRKSRVSV 430
Query: 398 IEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALEN 457
SG + K+K T P+ AP P +V L E+ E+
Sbjct: 431 SPGRTSGK----------------VTKHKGTEKRESPS-PAPKPRKV---ELSESE--ED 468
Query: 458 NTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDME 517
G A S S S+D K S + G P
Sbjct: 469 KGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRS 528
Query: 518 EKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRR 577
PS PRK S R T + R P+P PP P + P RR
Sbjct: 529 ASPS--PRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPP-------PRRRRTPTPPPRR 579
Query: 578 PEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLK 637
P P R + P R S S P ++ A+P P
Sbjct: 580 RTPSPPPRR-------------RSPSPRRYSPPIQRRYSPSP---PPKRRTASPPPP--- 620
Query: 638 SRPQVRPKPAPSPKTE----PPQGEDQVDIC-----NLRSKLRPAKSQDKSLLDGEGPQA 688
P+ R P+P PK PP + + +L SK R S +S + PQ
Sbjct: 621 --PKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQP 678
Query: 689 VGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQ 748
++ P P +P+ S P R ++ P + P
Sbjct: 679 --------NKRHSPSPRPR------------APQTSSSPPPVRRGASSSPQRRQSP---- 714
Query: 749 EAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFL 808
+P RP+ R P PKK ++ P P+ +P P A P P
Sbjct: 715 -SPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPA-AKKPPAPPSPVQ 772
Query: 809 SNS 811
S S
Sbjct: 773 SQS 775
Score = 51.6 bits (122), Expect = 3e-06
Identities = 71/306 (23%), Positives = 116/306 (37%), Gaps = 48/306 (15%)
Query: 509 EEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKH 568
EEI +E++ +K+ K + + E+E R++ E+ R P
Sbjct: 129 EEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPR--------------- 173
Query: 569 IPPARDSRRPEPKPDKSRLF-QLKNDMGLECGHKVLAKEVKKPNLRPISKSKT-DLPEEK 626
R SR P P+ S + + K H+ ++ P+ P K KT +LPE
Sbjct: 174 ---RRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRS---PSPAPEKKEKTPELPE-- 225
Query: 627 PDATPQNPFLKSRPQVR-----PKPAPSPKTEPPQGEDQVDICNLRSKLRP-AKSQDKSL 680
P + P ++ PKP P P+ + P E + K RP ++S+ KS
Sbjct: 226 PSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSR 285
Query: 681 LDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVS 740
+ +RS P R + R+ + + S R P P + T P
Sbjct: 286 --------------SRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPP-- 329
Query: 741 KSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLV 800
+ +P P + + PV RR SSSS R P + + ++P P + +
Sbjct: 330 RRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSP-PRKTRRL 388
Query: 801 PPKAKP 806
P A P
Sbjct: 389 SPSASP 394
Score = 31.6 bits (70), Expect = 3.5
Identities = 32/134 (23%), Positives = 50/134 (37%), Gaps = 12/134 (8%)
Query: 539 RERERQRTEQLRGPTPKP--PGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGL 596
RE + + P+P+P P P + + RR P P + ++
Sbjct: 671 REARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEP 730
Query: 597 ECGHKVLAKEVKKPNLRPISKSKTDLPE---EKPDATP-----QNPFLKSRPQVRPKPA- 647
+ K + + S+S + PE +KP A P Q+P P V K A
Sbjct: 731 KKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAK 790
Query: 648 -PSPKTEPPQGEDQ 660
P+P PP+ DQ
Sbjct: 791 SPTPSPSPPRNSDQ 804
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,051,804
Number of Sequences: 37866
Number of extensions: 2864244
Number of successful extensions: 20719
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 261
Number of HSP's successfully gapped in prelim test: 871
Number of HSP's that attempted gapping in prelim test: 13820
Number of HSP's gapped (non-prelim): 5999
length of query: 911
length of database: 18,247,518
effective HSP length: 111
effective length of query: 800
effective length of database: 14,044,392
effective search space: 11235513600
effective search space used: 11235513600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.