Search of human proteins with 46409330

Search of human proteins with 46409330

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
         (304 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46409330 solute carrier family 25, member 34 [Homo sapiens]        615   e-176
gi|41462412 solute carrier family 25, member 35 [Homo sapiens]        247   8e-66
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo...   150   1e-36
gi|13259541 uncoupling protein 2 [Homo sapiens]                       132   4e-31
gi|11225256 uncoupling protein 1 [Homo sapiens]                       129   2e-30
gi|108860679 solute carrier family 25, member 27 [Homo sapiens]       128   7e-30
gi|58197562 solute carrier family 25, member 30 [Homo sapiens]        123   2e-28
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]          122   3e-28
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic...   117   1e-26
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho...   115   5e-26
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H...   115   5e-26
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]         106   3e-23
gi|21314739 solute carrier family 25, member 32 [Homo sapiens]         94   2e-19
gi|13899342 solute carrier [Homo sapiens]                              88   1e-17
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s...    87   2e-17
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo...    87   2e-17
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy...    82   4e-16
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]         82   8e-16
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]        81   1e-15
gi|21361103 solute carrier family 25, member 12 [Homo sapiens]         79   5e-15
gi|116235462 solute carrier family 25, member 45 isoform a [Homo...    79   5e-15
gi|13994341 solute carrier family 25 member 2 [Homo sapiens]           79   6e-15
gi|86198310 solute carrier family 25, member 29 [Homo sapiens]         77   2e-14
gi|156071459 solute carrier family 25, member 5 [Homo sapiens]         72   5e-13
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit...    72   6e-13
gi|156071462 solute carrier family 25, member A6 [Homo sapiens]        72   8e-13
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]           72   8e-13
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade...    70   3e-12
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade...    69   7e-12
gi|48476342 solute carrier family 25, member 23 [Homo sapiens]         68   1e-11

>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
          Length = 304

 Score =  615 bits (1585), Expect = e-176
 Identities = 304/304 (100%), Positives = 304/304 (100%)

Query: 1   METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAV 60
           METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAV
Sbjct: 1   METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAV 60

Query: 61  ARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFV 120
           ARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFV
Sbjct: 61  ARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFV 120

Query: 121 GSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVG 180
           GSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVG
Sbjct: 121 GSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVG 180

Query: 181 SAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVD 240
           SAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVD
Sbjct: 181 SAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVD 240

Query: 241 TAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAGRAQ 300
           TAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAGRAQ
Sbjct: 241 TAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAGRAQ 300

Query: 301 HKGT 304
           HKGT
Sbjct: 301 HKGT 304


>gi|41462412 solute carrier family 25, member 35 [Homo sapiens]
          Length = 295

 Score =  247 bits (631), Expect = 8e-66
 Identities = 125/246 (50%), Positives = 161/246 (65%), Gaps = 6/246 (2%)

Query: 8   VDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLW 67
           +D ++   A C ACVFTNPLEVVKTR+QLQGELQA GTY R Y     +   + + DGL 
Sbjct: 1   MDFLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLA 60

Query: 68  GLQKGLAAGLLYQGLMNGVRFYCYSLACQAGL------TQQPGGTVVAGAVAGALGAFVG 121
            LQKGLA  LLYQ LMNG+R   Y LA   G       T  P  +  AGA+AG +GA++G
Sbjct: 61  ALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARSAAAGAMAGVMGAYLG 120

Query: 122 SPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGS 181
           SP Y++KT LQAQ  + +AVGHQ+ HQ +  AL  I ++ GL+GLW+G  G +PRV+VGS
Sbjct: 121 SPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGS 180

Query: 182 AAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDT 241
           + QL TF+S K  + + +  P  SW +AL   M+S IAVV+ M PFDV  TRLYNQP D 
Sbjct: 181 STQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYNQPTDA 240

Query: 242 AGRGQL 247
            G+ ++
Sbjct: 241 QGKNRV 246


>gi|21361114 solute carrier family 25 (mitochondrial carrier;
           oxoglutarate carrier), member 11 [Homo sapiens]
          Length = 314

 Score =  150 bits (380), Expect = 1e-36
 Identities = 99/297 (33%), Positives = 155/297 (52%), Gaps = 14/297 (4%)

Query: 3   TVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
           T P +V  + G  A   A VF  PL++VK R+QL GE    G   R Y     ++ ++ +
Sbjct: 18  TSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGE----GAKTREYKTSFHALTSILK 73

Query: 63  ADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ--AGLTQQPGGTV---VAGAVAGALG 117
           A+GL G+  GL+AGLL Q      R   Y++  +   G    P G +   V G  AGA G
Sbjct: 74  AEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATG 133

Query: 118 AFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRV 177
           AFVG+PA +   ++ A     +    +  ++ V  AL  I R++G+L LW+G    + R 
Sbjct: 134 AFVGTPAEVALIRMTAD--GRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARA 191

Query: 178 MVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQ 237
           +V +AAQLA+++ +K ++    +   D+ L      MIS +       P D+  TR+ N 
Sbjct: 192 VVVNAAQLASYSQSKQFLLDSGYF-SDNILCHFCASMISGLVTTAASMPVDIAKTRIQNM 250

Query: 238 PVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRK 294
            +   G+ +   GL D + K+ R EG  +L+KG  P Y RLGPHT+L+ +F +++ K
Sbjct: 251 RM-IDGKPEYKNGL-DVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305


>gi|13259541 uncoupling protein 2 [Homo sapiens]
          Length = 309

 Score =  132 bits (332), Expect = 4e-31
 Identities = 96/302 (31%), Positives = 147/302 (48%), Gaps = 25/302 (8%)

Query: 4   VPPAVDL-VLGA-SACCLACVFTNPLEVVKTRLQLQGELQA--RGTYPRPYHGFIASVAA 59
           VPP   +  LGA +A C+A + T PL+  K RLQ+QGE Q   R T    Y G + ++  
Sbjct: 9   VPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILT 68

Query: 60  VARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ----AGLTQQPGGTVVAGAVAGA 115
           + R +G   L  GL AGL  Q     VR   Y    Q           G  ++AG+  GA
Sbjct: 69  MVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGA 128

Query: 116 LGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVP 175
           L   V  P  ++K + QAQ  A    G    +Q+ + A +TI R++G  GLW+G    V 
Sbjct: 129 LAVAVAQPTDVVKVRFQAQARA----GGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVA 184

Query: 176 RVMVGSAAQLATFASAKAWVQKQQWLPED---SWLVALAGGMISSIAVVVVMTPFDVVST 232
           R  + + A+L T+   K  + K   + +D    +  A   G  ++    V+ +P DVV T
Sbjct: 185 RNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTT----VIASPVDVVKT 240

Query: 233 RLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDEL 292
           R  N  +     GQ Y     C + + ++EGP A YKG  P++LRLG   ++  + +++L
Sbjct: 241 RYMNSAL-----GQ-YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294

Query: 293 RK 294
           ++
Sbjct: 295 KR 296


>gi|11225256 uncoupling protein 1 [Homo sapiens]
          Length = 307

 Score =  129 bits (325), Expect = 2e-30
 Identities = 90/292 (30%), Positives = 138/292 (47%), Gaps = 17/292 (5%)

Query: 8   VDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLW 67
           V L     A CLA V T PL+  K RLQ+QGE          Y G + ++ AV + +G  
Sbjct: 15  VQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIR--YKGVLGTITAVVKTEGRM 72

Query: 68  GLQKGLAAGLLYQGLMNGVRFYCYSLACQ---AGLTQQP--GGTVVAGAVAGALGAFVGS 122
            L  GL AGL  Q     +R   Y    +   AG    P  G  ++AG   G +  F+G 
Sbjct: 73  KLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQ 132

Query: 123 PAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSA 182
           P  ++K +LQAQ+      G +  +     A   I   +GL GLW+G    + R ++ + 
Sbjct: 133 PTEVVKVRLQAQSHLH---GIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINC 189

Query: 183 AQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTA 242
            +L T+   K    K   L +D     L   +I+      + +P DVV TR  N P    
Sbjct: 190 TELVTYDLMKEAFVKNNILADDV-PCHLVSALIAGFCATAMSSPVDVVKTRFINSPP--- 245

Query: 243 GRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRK 294
             GQ Y  + +C +K++  EGP A +KGL P++LRLG   ++  + +++L++
Sbjct: 246 --GQ-YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294


>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
          Length = 323

 Score =  128 bits (321), Expect = 7e-30
 Identities = 86/304 (28%), Positives = 151/304 (49%), Gaps = 13/304 (4%)

Query: 5   PPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGE--LQARGTYPR---PYHGFIASVAA 59
           P A   +L   A  +A + T PL++ KTRLQ+QGE  L   G   R   PY G + +   
Sbjct: 18  PRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALG 77

Query: 60  VARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGG------TVVAGAVA 113
           +   +G   L +G+   +    + +G R   Y    +    +          +V+ G +A
Sbjct: 78  IIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMA 137

Query: 114 GALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGA 173
           G +G F+ +P  L+K Q+Q +    +  G     + V  A   I  + G+ GLW G    
Sbjct: 138 GVIGQFLANPTDLVKVQMQMEGKRKLE-GKPLRFRGVHHAFAKILAEGGIRGLWAGWVPN 196

Query: 174 VPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTR 233
           + R  + +   L T+ + K ++     L ED+ +      + S +   ++ TP DV+ +R
Sbjct: 197 IQRAALVNMGDLTTYDTVKHYLVLNTPL-EDNIMTHGLSSLCSGLVASILGTPADVIKSR 255

Query: 234 LYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR 293
           + NQP D  GRG LY   TDC+++  + EG ++LYKG  P++LR+ P +++  L ++++R
Sbjct: 256 IMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIR 315

Query: 294 KLAG 297
           +++G
Sbjct: 316 EMSG 319


>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
          Length = 291

 Score =  123 bits (309), Expect = 2e-28
 Identities = 83/291 (28%), Positives = 137/291 (47%), Gaps = 17/291 (5%)

Query: 11  VLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQ 70
           V G  A   A   T P+++ KTRLQ+QG+          Y G + ++  + R +GL  L 
Sbjct: 10  VYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALY 69

Query: 71  KGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT----VVAGAVAGALGAFVGSPAYL 126
            G+A  +L Q     ++   Y    +  + +    T    V+ G ++G + + + +P  +
Sbjct: 70  SGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTIANPTDV 129

Query: 127 IKTQLQAQ--TVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQ 184
           +K ++QAQ  T+    +G+  N          I++Q+G  GLW+GV     R  +    +
Sbjct: 130 LKIRMQAQSNTIQGGMIGNFMN----------IYQQEGTRGLWKGVSLTAQRAAIVVGVE 179

Query: 185 LATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGR 244
           L  +   K  +     L  D+            +A  +   P DVV TR+ NQ V   GR
Sbjct: 180 LPVYDITKKHLILSG-LMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGR 238

Query: 245 GQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKL 295
              Y G  DC+++ W+ EG  ALYKG  P +LRLGP  I+  + +++L+KL
Sbjct: 239 CSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKL 289



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 19/174 (10%)

Query: 2   ETVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGE-LQARGTYPRPYHGFIASVAAV 60
           ET+P  ++++ G  +  ++    NP +V+K R+Q Q   +Q          G I +   +
Sbjct: 104 ETLP--INVICGILSGVISSTIANPTDVLKIRMQAQSNTIQG---------GMIGNFMNI 152

Query: 61  ARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ-AGLTQQPGGTV----VAGAVAGA 115
            + +G  GL KG++       ++ GV    Y +  +   L+   G TV    ++    G 
Sbjct: 153 YQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGL 212

Query: 116 LGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQG 169
            GA   +P  +++T++  Q V  +  G    +   L  L   W+ +G   L++G
Sbjct: 213 AGALASNPVDVVRTRMMNQRV--LRDGRCSGYTGTLDCLLQTWKNEGFFALYKG 264


>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
          Length = 312

 Score =  122 bits (307), Expect = 3e-28
 Identities = 90/308 (29%), Positives = 145/308 (47%), Gaps = 22/308 (7%)

Query: 4   VPP--AVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPR-PYHGFIASVAAV 60
           VPP  AV  +   +A C A + T PL+  K RLQ+QGE QA  T     Y G + ++  +
Sbjct: 9   VPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTM 68

Query: 61  ARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT-----VVAGAVAGA 115
            R +G      GL AGL  Q     +R   Y    Q    +    +     ++AG   GA
Sbjct: 69  VRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGA 128

Query: 116 LGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALE---TIWRQQGLLGLWQGVGG 172
           +      P  ++K + QA    ++ +G   + +   G ++   TI R++G+ GLW+G   
Sbjct: 129 MAVTCAQPTDVVKVRFQA----SIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184

Query: 173 AVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVST 232
            + R  + + A++ T+   K  +     L  D++         +     VV +P DVV T
Sbjct: 185 NIMRNAIVNCAEVVTYDILKEKLLDYHLLT-DNFPCHFVSAFGAGFCATVVASPVDVVKT 243

Query: 233 RLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDEL 292
           R  N P      GQ +  L DCM+K+  QEGP A YKG  P++LRLG   ++  + +++L
Sbjct: 244 RYMNSPP-----GQYFSPL-DCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQL 297

Query: 293 RKLAGRAQ 300
           ++   + Q
Sbjct: 298 KRALMKVQ 305


>gi|20149598 solute carrier family 25 (mitochondrial carrier;
           dicarboxylate transporter), member 10 [Homo sapiens]
          Length = 287

 Score =  117 bits (293), Expect = 1e-26
 Identities = 92/290 (31%), Positives = 135/290 (46%), Gaps = 25/290 (8%)

Query: 13  GASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQKG 72
           G  A C A   T+PL+++K  LQ Q E++ R T              V R DG+  L  G
Sbjct: 13  GGLASCGAACCTHPLDLLKVHLQTQQEVKLRMT---------GMALRVVRTDGILALYSG 63

Query: 73  LAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT-----VVAGAVAGALGAFVGSPAYLI 127
           L+A L  Q   +  RF  Y            G       V+ G+V+G  G FVG+PA L+
Sbjct: 64  LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123

Query: 128 KTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLAT 187
             ++Q      +  G + N+   L  L  + R++GL  L+ G   A  R  + +  QL+ 
Sbjct: 124 NVRMQNDV--KLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSC 181

Query: 188 FASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQL 247
           +  AK  V    +L  D+         I+      +  P DV+ TRL N       +G+ 
Sbjct: 182 YDQAKQLVLSTGYL-SDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS------KGE- 233

Query: 248 YGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAG 297
           Y G+  C V+  +  GPLA YKGL PA +RL PHT+L+ +F ++LRK  G
Sbjct: 234 YQGVFHCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFG 282


>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
           sapiens]
          Length = 325

 Score =  115 bits (288), Expect = 5e-26
 Identities = 79/289 (27%), Positives = 139/289 (48%), Gaps = 14/289 (4%)

Query: 11  VLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQ 70
           V G  A  +A   T P+++ KTRLQ+QG+          Y G   ++  + + +G+  L 
Sbjct: 45  VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 104

Query: 71  KGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTV----VAGAVAGALGAFVGSPAYL 126
            G+A  LL Q     ++   Y    +  + +    T+    + G V+G + + + +P  +
Sbjct: 105 SGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDV 164

Query: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLA 186
           +K ++QAQ   ++  G      +++G+   I++Q+G  GLW+GV     R  +    +L 
Sbjct: 165 LKIRMQAQ--GSLFQG------SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELP 216

Query: 187 TFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQ 246
            +   K  +     +  D+ L          +A  +   P DVV TR+ NQ     G   
Sbjct: 217 VYDITKKHLILSGMMG-DTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRA-IVGHVD 274

Query: 247 LYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKL 295
           LY G  D ++K+W+ EG  ALYKG  P +LRLGP  I+  + +++L++L
Sbjct: 275 LYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 323



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 37/168 (22%), Positives = 75/168 (44%), Gaps = 18/168 (10%)

Query: 8   VDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHG-FIASVAAVARADGL 66
           ++++ G  +  ++    NP +V+K R+Q QG L         + G  I S   + + +G 
Sbjct: 143 INMICGVVSGVISSTIANPTDVLKIRMQAQGSL---------FQGSMIGSFIDIYQQEGT 193

Query: 67  WGLQKGLAAGLLYQGLMNGVRFYCYSLACQ-AGLTQQPGGTV----VAGAVAGALGAFVG 121
            GL +G+        ++ GV    Y +  +   L+   G T+    V+    G  GA   
Sbjct: 194 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 253

Query: 122 SPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQG 169
           +P  +++T++  Q      VGH   ++  +  +  +W+ +G   L++G
Sbjct: 254 NPVDVVRTRMMNQ---RAIVGHVDLYKGTVDGILKMWKHEGFFALYKG 298


>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
           sapiens]
          Length = 322

 Score =  115 bits (288), Expect = 5e-26
 Identities = 79/289 (27%), Positives = 139/289 (48%), Gaps = 14/289 (4%)

Query: 11  VLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQ 70
           V G  A  +A   T P+++ KTRLQ+QG+          Y G   ++  + + +G+  L 
Sbjct: 42  VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 101

Query: 71  KGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTV----VAGAVAGALGAFVGSPAYL 126
            G+A  LL Q     ++   Y    +  + +    T+    + G V+G + + + +P  +
Sbjct: 102 SGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDV 161

Query: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLA 186
           +K ++QAQ   ++  G      +++G+   I++Q+G  GLW+GV     R  +    +L 
Sbjct: 162 LKIRMQAQ--GSLFQG------SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELP 213

Query: 187 TFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQ 246
            +   K  +     +  D+ L          +A  +   P DVV TR+ NQ     G   
Sbjct: 214 VYDITKKHLILSGMMG-DTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRA-IVGHVD 271

Query: 247 LYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKL 295
           LY G  D ++K+W+ EG  ALYKG  P +LRLGP  I+  + +++L++L
Sbjct: 272 LYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 320



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 37/168 (22%), Positives = 75/168 (44%), Gaps = 18/168 (10%)

Query: 8   VDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHG-FIASVAAVARADGL 66
           ++++ G  +  ++    NP +V+K R+Q QG L         + G  I S   + + +G 
Sbjct: 140 INMICGVVSGVISSTIANPTDVLKIRMQAQGSL---------FQGSMIGSFIDIYQQEGT 190

Query: 67  WGLQKGLAAGLLYQGLMNGVRFYCYSLACQ-AGLTQQPGGTV----VAGAVAGALGAFVG 121
            GL +G+        ++ GV    Y +  +   L+   G T+    V+    G  GA   
Sbjct: 191 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 250

Query: 122 SPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQG 169
           +P  +++T++  Q      VGH   ++  +  +  +W+ +G   L++G
Sbjct: 251 NPVDVVRTRMMNQ---RAIVGHVDLYKGTVDGILKMWKHEGFFALYKG 295


>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
          Length = 275

 Score =  106 bits (264), Expect = 3e-23
 Identities = 83/278 (29%), Positives = 127/278 (45%), Gaps = 22/278 (7%)

Query: 4   VPP--AVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPR-PYHGFIASVAAV 60
           VPP  AV  +   +A C A + T PL+  K RLQ+QGE QA  T     Y G + ++  +
Sbjct: 9   VPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTM 68

Query: 61  ARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT-----VVAGAVAGA 115
            R +G      GL AGL  Q     +R   Y    Q    +    +     ++AG   GA
Sbjct: 69  VRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGA 128

Query: 116 LGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALE---TIWRQQGLLGLWQGVGG 172
           +      P  ++K + Q    A++ +G   + +   G ++   TI R++G+ GLW+G   
Sbjct: 129 MAVTCAQPTDVVKVRFQ----ASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184

Query: 173 AVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVST 232
            + R  + + A++ T+   K  +     L  D++         +     VV +P DVV T
Sbjct: 185 NIMRNAIVNCAEVVTYDILKEKLLDYHLL-TDNFPCHFVSAFGAGFCATVVASPVDVVKT 243

Query: 233 RLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKG 270
           R  N P      GQ +  L DCM+K+  QEGP A YKG
Sbjct: 244 RYMNSP-----PGQYFSPL-DCMIKMVAQEGPTAFYKG 275



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 43/189 (22%), Positives = 72/189 (38%), Gaps = 3/189 (1%)

Query: 108 VAGAVAGALGAFVGSPAYLIKTQLQAQTV-AAVAVGHQHNHQTVLGALETIWRQQGLLGL 166
           +    A      V  P    K +LQ Q    AV       ++ VLG + T+ R +G    
Sbjct: 18  LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77

Query: 167 WQGVGGAVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTP 226
           + G+   + R M  ++ ++  + S K  V   +     S    +  G  +    V    P
Sbjct: 78  YNGLVAGLQRQMSFASIRIGLYDSVKQ-VYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136

Query: 227 FDVVSTRLYNQ-PVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILS 285
            DVV  R      +  +   + Y G  D    I R+EG   L+KG  P  +R        
Sbjct: 137 TDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAE 196

Query: 286 MLFWDELRK 294
           ++ +D L++
Sbjct: 197 VVTYDILKE 205


>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
          Length = 315

 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 76/291 (26%), Positives = 140/291 (48%), Gaps = 19/291 (6%)

Query: 9   DLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWG 68
           +L+ G S   L+ +  +PL++VK R  +   L+ R   P+ Y+G +  +  + + DGL G
Sbjct: 25  NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELR---PK-YNGILHCLTTIWKLDGLRG 80

Query: 69  LQKGLAAGLLYQGLMNGVRFYCYSLACQ---AGLTQQPGGT--VVAGAVAGALGAFVGSP 123
           L +G+   +   GL  G+ F+ Y+        G  ++   T  +V+ A AGA+   + +P
Sbjct: 81  LYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNP 140

Query: 124 AYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAA 183
            ++ KT+L  Q  A V   H+  ++ +   L  I++ +G+ GL++G    +     G+  
Sbjct: 141 LWVTKTRLMLQYDAVVNSPHRQ-YKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGALQ 199

Query: 184 QLATFASAKAWVQKQQWLPED--SWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDT 241
            +A       + Q    LPE   S +  ++   +S I  V    P+ VV  RL +Q +  
Sbjct: 200 FMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHM-- 257

Query: 242 AGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDEL 292
                 Y G+ D + K WR+EG    YKG+ P  +R+ P   ++ + ++ +
Sbjct: 258 -----FYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 28/114 (24%), Positives = 54/114 (47%), Gaps = 8/114 (7%)

Query: 189 ASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLY 248
           + + AW    + +  ++ +  ++GG++S++A    + P D+V  R      D       Y
Sbjct: 9   SGSSAWSTVFRHVRYENLIAGVSGGVLSNLA----LHPLDLVKIRFAVS--DGLELRPKY 62

Query: 249 GGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR--KLAGRAQ 300
            G+  C+  IW+ +G   LY+G+ P     G    L   F++ ++  K  GRA+
Sbjct: 63  NGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAE 116


>gi|13899342 solute carrier [Homo sapiens]
          Length = 315

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 78/286 (27%), Positives = 122/286 (42%), Gaps = 39/286 (13%)

Query: 19  LACVFTNPLEVVKTRLQLQ-GELQARGTYPRPYHGFIASVAAVARADGLWGLQKGLAAGL 77
           + CVF  P+++ KTRLQ Q G+          Y G I  +   ARA+G +G+ +G A  L
Sbjct: 23  VTCVF--PIDLAKTRLQNQHGKAM--------YKGMIDCLMKTARAEGFFGMYRGAAVNL 72

Query: 78  LY----QGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFVGSPAYLIKTQLQA 133
                 + +      +   L  + G+ +     ++AG  AG     V  P  ++K QL  
Sbjct: 73  TLVTPEKAIKLAANDFFRRLLMEDGMQRNLKMEMLAGCGAGMCQVVVTCPMEMLKIQL-- 130

Query: 134 QTVAAVAVGHQ-------------------HNHQTVLGALETIWRQQGLLGLWQGVGGAV 174
           Q    +AV HQ                   H   +       + R QGL GL++G+G  +
Sbjct: 131 QDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYRGLGATL 190

Query: 175 PRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRL 234
            R +  S      FA+    +   +   + S+  +   G ++     V +TP DV+ TR+
Sbjct: 191 LRDIPFSIIYFPLFANLNN-LGFNELAGKASFAHSFVSGCVAGSIAAVAVTPLDVLKTRI 249

Query: 235 YNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGP 280
             Q +       +Y G+TDC  K+W QEGP A  KG G   L + P
Sbjct: 250 --QTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGAGCRALVIAP 293



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 5/86 (5%)

Query: 210 LAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYK 269
           L  G ++ +  V  + P D+  TRL NQ     G+  +Y G+ DC++K  R EG   +Y+
Sbjct: 12  LINGGVAGLVGVTCVFPIDLAKTRLQNQH----GKA-MYKGMIDCLMKTARAEGFFGMYR 66

Query: 270 GLGPAYLRLGPHTILSMLFWDELRKL 295
           G       + P   + +   D  R+L
Sbjct: 67  GAAVNLTLVTPEKAIKLAANDFFRRL 92



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 48/217 (22%), Positives = 85/217 (39%), Gaps = 33/217 (15%)

Query: 107 VVAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGL 166
           ++ G VAG +G     P  L KT+LQ Q   A+  G       ++  L    R +G  G+
Sbjct: 12  LINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKG-------MIDCLMKTARAEGFFGM 64

Query: 167 WQGVGGAVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTP 226
           ++G    +  V    A +LA     +  + +     + +  + +  G  + +  VVV  P
Sbjct: 65  YRGAAVNLTLVTPEKAIKLAANDFFRRLLMEDGM--QRNLKMEMLAGCGAGMCQVVVTCP 122

Query: 227 FDVVSTRLY-----------NQPVDTAGRGQLYG--------GLTDCMVKIWRQEGPLAL 267
            +++  +L            +    +  R    G          T    ++ R +G   L
Sbjct: 123 MEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGL 182

Query: 268 YKGLGPAYLRLGPHTILSMLFWDEL-----RKLAGRA 299
           Y+GLG   LR  P +I+    +  L      +LAG+A
Sbjct: 183 YRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKA 219


>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
           sapiens]
          Length = 675

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 69/197 (35%), Positives = 97/197 (49%), Gaps = 20/197 (10%)

Query: 3   TVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
           +VP A +++ G  A     +FTNPLE+VK RLQ+ GE+    T PR       S  +V R
Sbjct: 425 SVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEIT---TGPR------VSALSVVR 475

Query: 63  ADGLWGLQKGLAAGLLYQGLMNGVRFYCY-----SLACQAGLTQQPGGTVVAGAVAGALG 117
             G +G+ KG  A  L     + + F CY     S A + G    PG  ++AGA+AG   
Sbjct: 476 DLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQV-SPGSLLLAGAIAGMPA 534

Query: 118 AFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRV 177
           A + +PA +IKT+LQ   VAA A   Q  +  V+     I R++G   LW+G G  V R 
Sbjct: 535 ASLVTPADVIKTRLQ---VAARA--GQTTYSGVIDCFRKILREEGPKALWKGAGARVFRS 589

Query: 178 MVGSAAQLATFASAKAW 194
                  L T+   + W
Sbjct: 590 SPQFGVTLLTYELLQRW 606



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 76/290 (26%), Positives = 122/290 (42%), Gaps = 25/290 (8%)

Query: 12  LGASACCLACVFTNPLEVVKTRLQLQ---GELQARGTYPRPYHGFIASVAAVARADGLWG 68
           LG+ A  +      P+++VKTR+Q Q   G       Y   +  F      V R +G +G
Sbjct: 334 LGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCF----KKVLRYEGFFG 389

Query: 69  LQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPG----GTVVAGAVAGALGAFVGSPA 124
           L +GL   LL       ++           + +         ++AG  AG       +P 
Sbjct: 390 LYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPL 449

Query: 125 YLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQ 184
            ++K +LQ      +  G +      + AL  + R  G  G+++G      R +  SA  
Sbjct: 450 EIVKIRLQV--AGEITTGPR------VSALSVV-RDLGFFGIYKGAKACFLRDIPFSAIY 500

Query: 185 LATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGR 244
              +A  KA    +        L  L  G I+ +    ++TP DV+ TRL  Q    AG+
Sbjct: 501 FPCYAHVKASFANEDGQVSPGSL--LLAGAIAGMPAASLVTPADVIKTRL--QVAARAGQ 556

Query: 245 GQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRK 294
              Y G+ DC  KI R+EGP AL+KG G    R  P   +++L ++ L++
Sbjct: 557 -TTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 605


>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
           sapiens]
          Length = 676

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 69/197 (35%), Positives = 97/197 (49%), Gaps = 20/197 (10%)

Query: 3   TVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
           +VP A +++ G  A     +FTNPLE+VK RLQ+ GE+    T PR       S  +V R
Sbjct: 426 SVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEIT---TGPR------VSALSVVR 476

Query: 63  ADGLWGLQKGLAAGLLYQGLMNGVRFYCY-----SLACQAGLTQQPGGTVVAGAVAGALG 117
             G +G+ KG  A  L     + + F CY     S A + G    PG  ++AGA+AG   
Sbjct: 477 DLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQV-SPGSLLLAGAIAGMPA 535

Query: 118 AFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRV 177
           A + +PA +IKT+LQ   VAA A   Q  +  V+     I R++G   LW+G G  V R 
Sbjct: 536 ASLVTPADVIKTRLQ---VAARA--GQTTYSGVIDCFRKILREEGPKALWKGAGARVFRS 590

Query: 178 MVGSAAQLATFASAKAW 194
                  L T+   + W
Sbjct: 591 SPQFGVTLLTYELLQRW 607



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 76/290 (26%), Positives = 122/290 (42%), Gaps = 25/290 (8%)

Query: 12  LGASACCLACVFTNPLEVVKTRLQLQ---GELQARGTYPRPYHGFIASVAAVARADGLWG 68
           LG+ A  +      P+++VKTR+Q Q   G       Y   +  F      V R +G +G
Sbjct: 335 LGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCF----KKVLRYEGFFG 390

Query: 69  LQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPG----GTVVAGAVAGALGAFVGSPA 124
           L +GL   LL       ++           + +         ++AG  AG       +P 
Sbjct: 391 LYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPL 450

Query: 125 YLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQ 184
            ++K +LQ      +  G +      + AL  + R  G  G+++G      R +  SA  
Sbjct: 451 EIVKIRLQV--AGEITTGPR------VSALSVV-RDLGFFGIYKGAKACFLRDIPFSAIY 501

Query: 185 LATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGR 244
              +A  KA    +        L  L  G I+ +    ++TP DV+ TRL  Q    AG+
Sbjct: 502 FPCYAHVKASFANEDGQVSPGSL--LLAGAIAGMPAASLVTPADVIKTRL--QVAARAGQ 557

Query: 245 GQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRK 294
              Y G+ DC  KI R+EGP AL+KG G    R  P   +++L ++ L++
Sbjct: 558 -TTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 606


>gi|13449279 solute carrier family 25 (mitochondrial
           oxodicarboxylate carrier), member 21 [Homo sapiens]
          Length = 299

 Score = 82.4 bits (202), Expect = 4e-16
 Identities = 77/288 (26%), Positives = 131/288 (45%), Gaps = 22/288 (7%)

Query: 10  LVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGL 69
           +V G SA  +     +PL+VVKTR Q+Q       T P  Y   + S   + + +GL+G 
Sbjct: 17  IVAGGSAGLVEICLMHPLDVVKTRFQIQ----RCATDPNSYKSLVDSFRMIFQMEGLFGF 72

Query: 70  QKGLAAGLLYQGLMNGVRFYCYSLACQ--AGLTQQPGGT-VVAGAVAGALGAFVGSPAYL 126
            KG+   +L +     V+F+ +    +    ++  P  T  +AG  +G   A V +P  +
Sbjct: 73  YKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEV 132

Query: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQG--LLGLWQGVGGAVPRVMVGSAAQ 184
           +K  LQA               + +G    I +++G  L GL +G+   + R  V +   
Sbjct: 133 VKVGLQANRNTFA------EQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVY 186

Query: 185 LATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYN-QPVDTAG 243
              + + K  +   +    + W      G++S     V+  PFDV  +R+   QPV    
Sbjct: 187 FGFYYNVKNMIPVNKDPILEFWR-KFGIGLLSGTIASVINIPFDVAKSRIQGPQPVP--- 242

Query: 244 RGQL-YGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWD 290
            G++ Y      M  ++++EG LALYKGL P  +RLGP   + +L ++
Sbjct: 243 -GEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 47/199 (23%), Positives = 86/199 (43%), Gaps = 15/199 (7%)

Query: 5   PPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYP-RPYHGFIASVAAVARA 63
           P     + G  +     +  NP EVVK  LQ       R T+  +P     A        
Sbjct: 108 PALTFAIAGLGSGLTEAIVVNPFEVVKVGLQAN-----RNTFAEQPSTVGYARQIIKKEG 162

Query: 64  DGLWGLQKGLAAGLLYQGLMNGVRF-YCYSLACQAGLTQQP----GGTVVAGAVAGALGA 118
            GL GL KGL A L   G+ N V F + Y++     + + P          G ++G + +
Sbjct: 163 WGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIAS 222

Query: 119 FVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVM 178
            +  P  + K+++Q        V  +  ++T    + T+++++G+L L++G+   + R+ 
Sbjct: 223 VINIPFDVAKSRIQGPQ----PVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLG 278

Query: 179 VGSAAQLATFASAKAWVQK 197
            G A  L  +    +W+Q+
Sbjct: 279 PGGAVMLLVYEYTYSWLQE 297



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 41/195 (21%), Positives = 88/195 (45%), Gaps = 14/195 (7%)

Query: 96  QAGLTQQPGGTVVAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALE 155
           +  L ++    +VAG  AG +   +  P  ++KT+ Q Q  A       +++++++ +  
Sbjct: 6   EVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCAT----DPNSYKSLVDSFR 61

Query: 156 TIWRQQGLLGLWQGVGGAVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMI 215
            I++ +GL G ++G+   +P ++  +  +   F + + + +   ++     L     G+ 
Sbjct: 62  MIFQMEGLFGFYKGI---LPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLG 118

Query: 216 SSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKI-WRQEGPLALYKGLGPA 274
           S +   +V+ PF+VV   L       A +    G     + K  W  +G   L KGL   
Sbjct: 119 SGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQG---LNKGLTAT 175

Query: 275 YLRLGPHTILSMLFW 289
              LG H + +M+++
Sbjct: 176 ---LGRHGVFNMVYF 187



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 27/88 (30%), Positives = 40/88 (45%), Gaps = 3/88 (3%)

Query: 210 LAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYK 269
           +AGG  + +  + +M P DVV TR   Q   T      Y  L D    I++ EG    YK
Sbjct: 18  VAGGS-AGLVEICLMHPLDVVKTRFQIQRCATDPNS--YKSLVDSFRMIFQMEGLFGFYK 74

Query: 270 GLGPAYLRLGPHTILSMLFWDELRKLAG 297
           G+ P  L   P   +    +++ +KL G
Sbjct: 75  GILPPILAETPKRAVKFFTFEQYKKLLG 102


>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
          Length = 308

 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 87/320 (27%), Positives = 133/320 (41%), Gaps = 48/320 (15%)

Query: 8   VDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLW 67
           +D V GA           PL+ VK R+Q         T P+ Y G    V      + +W
Sbjct: 1   MDFVAGAIGGVCGVAVGYPLDTVKVRIQ---------TEPK-YTGIWHCVRDTYHRERVW 50

Query: 68  GLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT----------VVAGAVAGALG 117
           G  +GL+  +    L++ V F  Y   C A + +   G            ++G  +G + 
Sbjct: 51  GFYRGLSLPVCTVSLVSSVSFGTYR-HCLAHICRLRYGNPDAKPTKADITLSGCASGLVR 109

Query: 118 AFVGSPAYLIKTQLQAQTVAA-----------VAVGH---------QHNHQTVLGALETI 157
            F+ SP  + K +LQ QT A            +AV           +  ++  L  L T+
Sbjct: 110 VFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATV 169

Query: 158 WRQQGLLGLWQGVGGAVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISS 217
            R++GL GL++G    V R     A    ++A    W+        D   V +AGG    
Sbjct: 170 AREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGV 229

Query: 218 IAVVVVMTPFDVVSTRLYNQPVDTAGRGQL-YGGLTDCMVKIWRQEGPLALYKGLGPAYL 276
           +A  V  TP DV+ +RL        G+GQ  Y GL  CMV   R+EGP  L+KGL     
Sbjct: 230 LAWAVA-TPMDVIKSRL-----QADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCC 283

Query: 277 RLGPHTILSMLFWDELRKLA 296
           R  P  ++  + ++ + +LA
Sbjct: 284 RAFPVNMVVFVAYEAVLRLA 303



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 60/192 (31%), Positives = 88/192 (45%), Gaps = 32/192 (16%)

Query: 5   PPAVDLVLGASACCLACVF-TNPLEVVKTRLQLQGELQARG------------------- 44
           P   D+ L   A  L  VF T+P EV K RLQ Q + Q +                    
Sbjct: 93  PTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPP 152

Query: 45  TYPRP-YHGFIASVAAVARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ----AGL 99
             P P Y G +  +A VAR +GL GL KG +A +L  G      F  Y++ C+    AG 
Sbjct: 153 ACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGH 212

Query: 100 TQ-QPGGTVVAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIW 158
           ++    G +VAG  AG L   V +P  +IK++LQA          Q  ++ +L  + T  
Sbjct: 213 SRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQG------QRRYRGLLHCMVTSV 266

Query: 159 RQQGLLGLWQGV 170
           R++G   L++G+
Sbjct: 267 REEGPRVLFKGL 278


>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
          Length = 301

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 75/302 (24%), Positives = 123/302 (40%), Gaps = 25/302 (8%)

Query: 4   VPPAVDLVLGASACCLACVFTN-PLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
           +  A+DL  GA+    ACV T  P + +K ++Q         T+P  Y G          
Sbjct: 7   IQAAIDLTAGAAGGT-ACVLTGQPFDTMKVKMQ---------TFPDLYRGLTDCCLKTYS 56

Query: 63  ADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ-----AGLTQQPG----GTVVAGAVA 113
             G  G  KG +  L+     N V F CY    Q     AGL +Q          AG+ A
Sbjct: 57  QVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFA 116

Query: 114 GALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGA 173
            A  A V  P  L+K +LQ       +     +  TV   +++I R+ G LG + G+   
Sbjct: 117 SAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSST 176

Query: 174 VPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTR 233
           + R + G       +  ++++    +   E   +  +  G +  I + + + P D + +R
Sbjct: 177 LLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSR 236

Query: 234 LYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR 293
           +  Q +  +G+     G     + + + EG  ALY GL P  +R  P      L ++  R
Sbjct: 237 I--QVLSMSGK---QAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSR 291

Query: 294 KL 295
           KL
Sbjct: 292 KL 293



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 41/192 (21%), Positives = 79/192 (41%), Gaps = 13/192 (6%)

Query: 13  GASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQKG 72
           G+ A   A +   P E+VK RLQ   E++  G   +  +   + + ++ R DG  G   G
Sbjct: 113 GSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHG 172

Query: 73  LAAGLLYQGLMNGVRFYCYSLA---CQAGLTQQPGGTV---VAGAVAGALGAFVGSPAYL 126
           L++ LL +       F  Y L+     +G ++   G V   ++G V G        P   
Sbjct: 173 LSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDC 232

Query: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLA 186
           IK+++Q  +++    G       V+       + +G+  L+ G+   + R    + A   
Sbjct: 233 IKSRIQVLSMSGKQAGFIRTFINVV-------KNEGITALYSGLKPTMIRAFPANGALFL 285

Query: 187 TFASAKAWVQKQ 198
            +  ++  +  Q
Sbjct: 286 AYEYSRKLMMNQ 297


>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
          Length = 678

 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 76/302 (25%), Positives = 128/302 (42%), Gaps = 27/302 (8%)

Query: 1   METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQ---GELQARGTYPRPYHGFIASV 57
           ++    A    LG+ A  +      P+++VKTR+Q Q   G +     Y   +  F    
Sbjct: 321 LQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCF---- 376

Query: 58  AAVARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT-----VVAGAV 112
             V R +G +GL +GL   L+       ++        +   T++ G       V+AG  
Sbjct: 377 KKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFV-RDKFTRRDGSVPLPAEVLAGGC 435

Query: 113 AGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGG 172
           AG       +P  ++K +LQ      +  G + +   VL       R  G+ GL++G   
Sbjct: 436 AGGSQVIFTNPLEIVKIRLQV--AGEITTGPRVSALNVL-------RDLGIFGLYKGAKA 486

Query: 173 AVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVST 232
              R +  SA     +A  K  +  +        L  LA G ++ +    ++TP DV+ T
Sbjct: 487 CFLRDIPFSAIYFPVYAHCKLLLADENG--HVGGLNLLAAGAMAGVPAASLVTPADVIKT 544

Query: 233 RLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDEL 292
           RL  Q    AG+   Y G+ DC  KI R+EGP A +KG      R  P   ++++ ++ L
Sbjct: 545 RL--QVAARAGQ-TTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELL 601

Query: 293 RK 294
           ++
Sbjct: 602 QR 603



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 64/197 (32%), Positives = 92/197 (46%), Gaps = 20/197 (10%)

Query: 3   TVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
           +VP   +++ G  A     +FTNPLE+VK RLQ+ GE+    T PR       S   V R
Sbjct: 423 SVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEIT---TGPR------VSALNVLR 473

Query: 63  ADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPG-----GTVVAGAVAGALG 117
             G++GL KG  A  L     + + F  Y+  C+  L  + G       + AGA+AG   
Sbjct: 474 DLGIFGLYKGAKACFLRDIPFSAIYFPVYA-HCKLLLADENGHVGGLNLLAAGAMAGVPA 532

Query: 118 AFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRV 177
           A + +PA +IKT+LQ   VAA A   Q  +  V+     I R++G    W+G    V R 
Sbjct: 533 ASLVTPADVIKTRLQ---VAARA--GQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRS 587

Query: 178 MVGSAAQLATFASAKAW 194
                  L T+   + W
Sbjct: 588 SPQFGVTLVTYELLQRW 604


>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
           sapiens]
          Length = 288

 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 82/307 (26%), Positives = 129/307 (42%), Gaps = 35/307 (11%)

Query: 6   PAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADG 65
           P  + V G  +  L  V  +P + VK RLQ Q            Y G +  +  + R + 
Sbjct: 2   PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQ----------TTYRGIVDCMVKIYRHES 51

Query: 66  LWGLQKGLAAGLLYQGLMNGVRFYCYS--------LACQAGLTQQPG--GTVVAGAVAGA 115
           L G  KG++  +    ++N V F  YS         + Q    Q P      +AG   G 
Sbjct: 52  LLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGF 111

Query: 116 LGAFVGSPAYLIKTQLQAQTVAAVAVGHQH-NHQTVLGALETIWRQQGLLGLWQGVGGAV 174
           L A+  +P  LIK +LQ QT      G     +Q  +    +I+R++G  GL++G     
Sbjct: 112 LQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALT 171

Query: 175 PRVMVGSAAQLATFASAKAWVQKQQWLPE----DSWLVALAGGMISSIAVVVVMTPFDVV 230
            R          T+         +Q+ PE     S  V +AGG  + IA  V  TP D++
Sbjct: 172 LRDTPTVGIYFITYEGLC-----RQYTPEGQNPSSATVLVAGGF-AGIASWVAATPLDMI 225

Query: 231 STRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWD 290
            +R+    +    R ++Y G+ DCMV   RQEG    ++G+     R  P   ++ L ++
Sbjct: 226 KSRMQMDGL----RRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 281

Query: 291 ELRKLAG 297
            L +  G
Sbjct: 282 YLLRWWG 288


>gi|13994341 solute carrier family 25 member 2 [Homo sapiens]
          Length = 301

 Score = 78.6 bits (192), Expect = 6e-15
 Identities = 72/302 (23%), Positives = 126/302 (41%), Gaps = 25/302 (8%)

Query: 4   VPPAVDLVLGASACCLACVFTN-PLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
           +  A+DL  GA+    ACV T  P + +K ++Q         T+P  Y G          
Sbjct: 7   IQAAIDLTAGAAGGT-ACVLTGQPFDTIKVKMQ---------TFPDLYKGLTDCFLKTYA 56

Query: 63  ADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ-----AGLTQQPG----GTVVAGAVA 113
             GL G  KG    L+     N V F CY    Q     AG+ +Q       T  AG+ A
Sbjct: 57  QVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFA 116

Query: 114 GALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGA 173
            A  A    P  L+K +LQ      ++     +H T+   ++ I ++ G LG + G+   
Sbjct: 117 SAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSST 176

Query: 174 VPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTR 233
           + + + G       +  ++++    +   E   +  +  G ++ I + +V+ P D + +R
Sbjct: 177 LLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSR 236

Query: 234 LYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR 293
           +  Q +   G+     G    ++ + R EG +ALY GL    +R  P      + ++  R
Sbjct: 237 I--QVLSMYGK---QAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSR 291

Query: 294 KL 295
           K+
Sbjct: 292 KM 293



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 46/192 (23%), Positives = 86/192 (44%), Gaps = 13/192 (6%)

Query: 13  GASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQKG 72
           G+ A   A +   P E+VK RLQ   E++  G   + ++   + V  + + DG  G   G
Sbjct: 113 GSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHG 172

Query: 73  LAAGLLYQGLMNGVRFYCYSLA---CQAGLTQQPGGTV---VAGAVAGALGAFVGSPAYL 126
           L++ LL +       F  Y L+     +G ++   G V   ++G VAG     V  P   
Sbjct: 173 LSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDC 232

Query: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLA 186
           IK+++Q  ++     G        +G L ++ R +G++ L+ G+   + R +  + A   
Sbjct: 233 IKSRIQVLSMYGKQAG-------FIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFV 285

Query: 187 TFASAKAWVQKQ 198
            +  ++  + KQ
Sbjct: 286 AYEYSRKMMMKQ 297



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 30/94 (31%), Positives = 45/94 (47%), Gaps = 11/94 (11%)

Query: 208 VALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLAL 267
           + L  G     A V+   PFD +  ++   P        LY GLTDC +K + Q G    
Sbjct: 11  IDLTAGAAGGTACVLTGQPFDTIKVKMQTFP-------DLYKGLTDCFLKTYAQVGLRGF 63

Query: 268 YKGLGPAYLR-LGPHTILSMLF---WDELRKLAG 297
           YKG GPA +  +  +++L M +      +RK+AG
Sbjct: 64  YKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAG 97


>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
          Length = 303

 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 76/277 (27%), Positives = 118/277 (42%), Gaps = 21/277 (7%)

Query: 7   AVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGL 66
           A+D + G +      +  +P + VK RLQ+Q   + +      Y G +    ++ + + +
Sbjct: 2   ALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQ------YRGTLHCFKSIIKQESV 55

Query: 67  WGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFVGSPAYL 126
            GL KGL + L+    +N + F       +A     P    +AGA AGA+   +  P  L
Sbjct: 56  LGLYKGLGSPLMGLTFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICCPMEL 115

Query: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLA 186
            KT+LQ Q       G    ++  L  L  I+  +GL G+ +G+   + R          
Sbjct: 116 AKTRLQLQD-----AGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFL 170

Query: 187 TFASAKAWVQKQQWLPEDSWLV---ALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAG 243
           T+    A  +     P D  LV    LAGG  S I   +   P DVV +RL    +  A 
Sbjct: 171 TY---DALTRALGCEPGDRLLVPKLLLAGG-TSGIVSWLSTYPVDVVKSRLQADGLRGAP 226

Query: 244 RGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGP 280
           R   Y G+ DC+ + +R EG     +GL    LR  P
Sbjct: 227 R---YRGILDCVHQSYRAEGWRVFTRGLASTLLRAFP 260



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 54/213 (25%), Positives = 94/213 (44%), Gaps = 15/213 (7%)

Query: 6   PAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADG 65
           P    + GA+A  + CV   P+E+ KTRLQLQ    A     R Y G +  +A +   +G
Sbjct: 92  PLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPA-----RTYKGSLDCLAQIYGHEG 146

Query: 66  LWGLQKGLAAGLLYQGLMNGVRFYCY-----SLACQAGLTQQPGGTVVAGAVAGALGAFV 120
           L G+ +G+ + LL +    GV F  Y     +L C+ G        ++AG  +G +    
Sbjct: 147 LRGVNRGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLS 206

Query: 121 GSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVG 180
             P  ++K++LQA  +          ++ +L  +   +R +G     +G+   + R    
Sbjct: 207 TYPVDVVKSRLQADGLRGAP-----RYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPV 261

Query: 181 SAAQLATFASAKAWVQKQQWLPEDSWLVALAGG 213
           +AA  AT      + + ++  PE   + A   G
Sbjct: 262 NAATFATVTVVLTYARGEEAGPEGEAVPAAPAG 294



 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 53/193 (27%), Positives = 87/193 (45%), Gaps = 21/193 (10%)

Query: 108 VAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLW 167
           +AG   G  G  VG P   +K +LQ Q+V       +  ++  L   ++I +Q+ +LGL+
Sbjct: 6   LAGCAGGVAGVLVGHPFDTVKVRLQVQSV------EKPQYRGTLHCFKSIIKQESVLGLY 59

Query: 168 QGVGGAVPRVMVGSAAQLATFASAKAW-VQKQ--QWLPEDSWLVALAGGMISSIAVVVVM 224
           +G+G  +  +         TF +A  + VQ    + L  DS L     G  +     V+ 
Sbjct: 60  KGLGSPLMGL---------TFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVIC 110

Query: 225 TPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTIL 284
            P ++  TRL  Q    AG  + Y G  DC+ +I+  EG   + +G+    LR  P   +
Sbjct: 111 CPMELAKTRLQLQD---AGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGV 167

Query: 285 SMLFWDELRKLAG 297
             L +D L +  G
Sbjct: 168 YFLTYDALTRALG 180


>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
          Length = 298

 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 74/299 (24%), Positives = 127/299 (42%), Gaps = 22/299 (7%)

Query: 7   AVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGL 66
           A D + G  A  ++     P+E VK  LQ+Q     + T  + Y G I  V  + +  G+
Sbjct: 9   AKDFLAGGVAAAISKTAVAPIERVKLLLQVQ-HASKQITADKQYKGIIDCVVRIPKEQGV 67

Query: 67  WGLQKGLAAGLLYQGLMNGVRFYC---YSLACQAGLTQQP------GGTVVAGAVAGALG 117
               +G  A ++       + F     Y      G+ ++        G + +G  AGA  
Sbjct: 68  LSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATS 127

Query: 118 AFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRV 177
                P    +T+L A    A   G +   + +   L  I++  G+ GL+QG   +V  +
Sbjct: 128 LCFVYPLDFARTRLAADVGKA---GAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGI 184

Query: 178 MVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMT--PFDVVSTRLY 235
           ++  AA    + +AK  +      P+++ +V ++  +  ++  V  +T  PFD V  R+ 
Sbjct: 185 IIYRAAYFGIYDTAKGMLPD----PKNTHIV-ISWMIAQTVTAVAGLTSYPFDTVRRRMM 239

Query: 236 NQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRK 294
            Q     G   +Y G  DC  KI R EG  A +KG     LR G      ++ +DE++K
Sbjct: 240 MQS-GRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDEIKK 296



 Score = 35.4 bits (80), Expect = 0.063
 Identities = 24/87 (27%), Positives = 45/87 (51%), Gaps = 2/87 (2%)

Query: 210 LAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTA-GRGQLYGGLTDCMVKIWRQEGPLALY 268
           LAGG+ ++I+   V  P + V   L  Q         + Y G+ DC+V+I +++G L+ +
Sbjct: 13  LAGGVAAAISKTAV-APIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFW 71

Query: 269 KGLGPAYLRLGPHTILSMLFWDELRKL 295
           +G     +R  P   L+  F D+ +++
Sbjct: 72  RGNLANVIRYFPTQALNFAFKDKYKQI 98


>gi|21389315 solute carrier family 25 (mitochondrial carrier;
           citrate transporter), member 1 precursor [Homo sapiens]
          Length = 311

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 76/298 (25%), Positives = 121/298 (40%), Gaps = 21/298 (7%)

Query: 6   PAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADG 65
           P   ++ G  A  +    T P E VKT+LQL        ++P  Y G    V    R+ G
Sbjct: 25  PGKAILAGGLAGGIEICITFPTEYVKTQLQLDER-----SHPPRYRGIGDCVRQTVRSHG 79

Query: 66  LWGLQKGLAAGLLYQGLMNG-VRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFVGSPA 124
           + GL +GL++ LLY  +    VRF  +          Q       G + G LGA V    
Sbjct: 80  VLGLYRGLSS-LLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCG-LGAGVAEAV 137

Query: 125 YLIKTQLQAQTVAAVAVGHQHN----HQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVG 180
            ++      +T+    +  Q +    ++     +  I R+QGL G +QG+   V +    
Sbjct: 138 VVV---CPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSN 194

Query: 181 SAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVD 240
            A +     S + W +        + L+    G I+  A V   TP DV+ TR+      
Sbjct: 195 QAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGL--- 251

Query: 241 TAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAGR 298
                  Y    DC ++I ++EG  A YKG  P   R+     +  + +DE+ KL  +
Sbjct: 252 ---EAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNK 306


>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
          Length = 298

 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 73/303 (24%), Positives = 124/303 (40%), Gaps = 28/303 (9%)

Query: 7   AVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGL 66
           A D + G  A  ++     P+E VK  LQ+Q     +    + Y G +  +  + +  G+
Sbjct: 9   AKDFLAGGIAAAISKTAVAPIERVKLLLQVQ-HASKQIAADKQYKGIVDCIVRIPKEQGV 67

Query: 67  WGLQKGLAAGLLYQGLMNGVRFYC---YSLACQAGLTQQP------GGTVVAGAVAGALG 117
               +G  A ++       + F     Y      G+ +         G + +G  AGA  
Sbjct: 68  LSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATS 127

Query: 118 AFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRV 177
                P    +T+L A    +   G +   + +   L  I +  G+ GL+QG   +V  +
Sbjct: 128 LCFVYPLDFARTRLAADVGKS---GTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGI 184

Query: 178 MVGSAAQLATFASAKAWVQKQQWLPED-----SWLVALAGGMISSIAVVVVMTPFDVVST 232
           ++  AA    + +AK  +      P++     SW++A     ++     VV  PFD V  
Sbjct: 185 IIYRAAYFGVYDTAKGMLPD----PKNTHIVVSWMIAQTVTAVAG----VVSYPFDTVRR 236

Query: 233 RLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDEL 292
           R+  Q     G   +Y G  DC  KI+R EG  A +KG     LR G      ++ +DEL
Sbjct: 237 RMMMQS-GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDEL 294

Query: 293 RKL 295
           +K+
Sbjct: 295 KKV 297


>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
          Length = 323

 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 75/284 (26%), Positives = 117/284 (41%), Gaps = 40/284 (14%)

Query: 19  LACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQKGLAAGLL 78
           + CVF  P+++ KTRLQ Q   Q      R Y      +    R++G +G+ +G A  L 
Sbjct: 23  VTCVF--PIDLAKTRLQNQQNGQ------RVYTSMSDCLIKTVRSEGYFGMYRGAAVNLT 74

Query: 79  YQGLMNGVR-----FYCYSLACQAGLTQQPGGTVVAGAVAGALGAFVGSPAYLIKTQLQ- 132
                  ++     F+ + L+ + G        ++AG  AG     V +P  ++K QLQ 
Sbjct: 75  LVTPEKAIKLAANDFFRHQLS-KDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQD 133

Query: 133 ------------AQTVAAVAVGHQHN-------HQTVLGALETIWRQQGLLGLWQGVGGA 173
                       AQ   +   G Q +         T       + R +G+ GL++G+G  
Sbjct: 134 AGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGAT 193

Query: 174 VPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTR 233
           + R +  S      FA+    + +     +  + V+   G ++  A  V + P DVV TR
Sbjct: 194 LLRDVPFSVVYFPLFANLNQ-LGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTR 252

Query: 234 LYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLR 277
           L  Q +        Y G+ DC  KI R EGP A  KG   AY R
Sbjct: 253 L--QSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG---AYCR 291



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 54/222 (24%), Positives = 88/222 (39%), Gaps = 38/222 (17%)

Query: 107 VVAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGL 166
           ++ G +AG +G     P  L KT+LQ Q         Q  + ++   L    R +G  G+
Sbjct: 12  LINGGIAGLIGVTCVFPIDLAKTRLQNQQ------NGQRVYTSMSDCLIKTVRSEGYFGM 65

Query: 167 WQGVGGAVPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAV----VV 222
           ++G    +  V    A +LA    A  + + Q  L +D   + L   M++        V+
Sbjct: 66  YRGAAVNLTLVTPEKAIKLA----ANDFFRHQ--LSKDGQKLTLLKEMLAGCGAGTCQVI 119

Query: 223 VMTPFDVVSTRLYN------QPVDTAGRGQL--YGGL--------------TDCMVKIWR 260
           V TP +++  +L +      Q    A +GQL   GG               T     + R
Sbjct: 120 VTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLR 179

Query: 261 QEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAGRAQHK 302
             G   LYKGLG   LR  P +++    +  L +L   A  +
Sbjct: 180 SRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEE 221



 Score = 35.8 bits (81), Expect = 0.048
 Identities = 34/105 (32%), Positives = 41/105 (39%), Gaps = 7/105 (6%)

Query: 2   ETVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVA 61
           E  P  V  + G  A   A V  NP +VVKTRLQ    LQ RG     Y G +     + 
Sbjct: 221 EKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQ---SLQ-RGVNEDTYSGILDCARKIL 276

Query: 62  RADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ---AGLTQQP 103
           R +G     KG     L    + G+    Y L       GL Q P
Sbjct: 277 RHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQDP 321


>gi|13775208 solute carrier family 25 (mitochondrial carrier;
           adenine nucleotide translocator), member 31 [Homo
           sapiens]
          Length = 315

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 68/296 (22%), Positives = 125/296 (42%), Gaps = 22/296 (7%)

Query: 9   DLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWG 68
           DL+ G  A  ++     P+E VK  LQ+Q   +      R Y G +  +  + R  G + 
Sbjct: 23  DLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEAR-YKGMVDCLVRIPREQGFFS 81

Query: 69  LQKGLAAGLLYQGLMNGVRFYC---YSLACQAGLTQQPG------GTVVAGAVAGALGAF 119
             +G  A ++       + F     Y     +G+ ++          + +G  AGA    
Sbjct: 82  FWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLC 141

Query: 120 VGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLG-ALETIWRQQGLLGLWQGVGGAVPRVM 178
           V  P    +T+L       +  G +      LG  +  I +  G+ GL+QG G +V  ++
Sbjct: 142 VVYPLDFARTRLGVD----IGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGII 197

Query: 179 VGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQP 238
           V  A+    + + K  + K +  P   +LV+     + +    ++  PFD V  R+  Q 
Sbjct: 198 VYRASYFGAYDTVKGLLPKPKKTP---FLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQS 254

Query: 239 VDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRK 294
            +   +   Y G  DC VKI++ EG  + ++G     LR G    L ++ +D++++
Sbjct: 255 GEAKRQ---YKGTLDCFVKIYQHEGISSFFRGAFSNVLR-GTGGALVLVLYDKIKE 306



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 48/176 (27%), Positives = 76/176 (43%), Gaps = 13/176 (7%)

Query: 104 GGTVVAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGL 163
           G  ++AG VA A+     +P   +K  LQ Q  ++  +  +  ++ ++  L  I R+QG 
Sbjct: 21  GKDLLAGGVAAAVSKTAVAPIERVKLLLQVQA-SSKQISPEARYKGMVDCLVRIPREQGF 79

Query: 164 LGLWQGVGGAVPRVMVGSAAQLATFASAKAWV------QKQQWLPEDSWLVA-LAGGMIS 216
              W+G    V R     A   A     K         +KQ W     W +A LA G  +
Sbjct: 80  FSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFW----RWFLANLASGGAA 135

Query: 217 SIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLG 272
               + V+ P D   TRL    +      + + GL DC++KI + +G   LY+G G
Sbjct: 136 GATSLCVVYPLDFARTRL-GVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFG 190



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 24/87 (27%), Positives = 44/87 (50%), Gaps = 2/87 (2%)

Query: 210 LAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQL-YGGLTDCMVKIWRQEGPLALY 268
           LAGG+ ++++   V  P + V   L  Q        +  Y G+ DC+V+I R++G  + +
Sbjct: 25  LAGGVAAAVSKTAV-APIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFSFW 83

Query: 269 KGLGPAYLRLGPHTILSMLFWDELRKL 295
           +G     +R  P   L+  F D+ ++L
Sbjct: 84  RGNLANVIRYFPTQALNFAFKDKYKQL 110


>gi|55749577 solute carrier family 25 (mitochondrial carrier;
           adenine nucleotide translocator), member 4 [Homo
           sapiens]
          Length = 298

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 74/301 (24%), Positives = 122/301 (40%), Gaps = 30/301 (9%)

Query: 9   DLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWG 68
           D + G  A  ++     P+E VK  LQ+Q     + +  + Y G I  V  + +  G   
Sbjct: 11  DFLAGGVAAAVSKTAVAPIERVKLLLQVQ-HASKQISAEKQYKGIIDCVVRIPKEQGFLS 69

Query: 69  LQKGLAAGLLYQGLMNGVRFYC---YSLACQAGLTQQP------GGTVVAGAVAGALGAF 119
             +G  A ++       + F     Y      G+ +         G + +G  AGA    
Sbjct: 70  FWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLC 129

Query: 120 VGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLG-ALETIWRQQGLLGLWQGVGGAVPRVM 178
              P    +T+L A      A    H     LG  +  I++  GL GL+QG   +V  ++
Sbjct: 130 FVYPLDFARTRLAADVGKGAAQREFHG----LGDCIIKIFKSDGLRGLYQGFNVSVQGII 185

Query: 179 VGSAAQLATFASAKAWVQKQQWLPED-----SWLVALAGGMISSIAVVVVMTPFDVVSTR 233
           +  AA    + +AK  +      P++     SW++A +   ++ +    V  PFD V  R
Sbjct: 186 IYRAAYFGVYDTAKGMLPD----PKNVHIFVSWMIAQSVTAVAGL----VSYPFDTVRRR 237

Query: 234 LYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR 293
           +  Q     G   +Y G  DC  KI + EG  A +KG     LR G      ++ +DE++
Sbjct: 238 MMMQS-GRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLR-GMGGAFVLVLYDEIK 295

Query: 294 K 294
           K
Sbjct: 296 K 296



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 43/191 (22%), Positives = 74/191 (38%), Gaps = 8/191 (4%)

Query: 7   AVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGL 66
           A +L  G +A   +  F  PL+  +TRL        +G   R +HG    +  + ++DGL
Sbjct: 114 AGNLASGGAAGATSLCFVYPLDFARTRLAAD---VGKGAAQREFHGLGDCIIKIFKSDGL 170

Query: 67  WGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT--VVAGAVAGALGAFVGSPA 124
            GL +G    +    +     F  Y  A   G+   P      V+  +A ++ A  G  +
Sbjct: 171 RGLYQGFNVSVQGIIIYRAAYFGVYDTA--KGMLPDPKNVHIFVSWMIAQSVTAVAGLVS 228

Query: 125 YLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQ 184
           Y   T  +   + +   G    +   +     I + +G    ++G    V R M G A  
Sbjct: 229 YPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGM-GGAFV 287

Query: 185 LATFASAKAWV 195
           L  +   K +V
Sbjct: 288 LVLYDEIKKYV 298



 Score = 36.2 bits (82), Expect = 0.037
 Identities = 27/96 (28%), Positives = 49/96 (51%), Gaps = 4/96 (4%)

Query: 210 LAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTA-GRGQLYGGLTDCMVKIWRQEGPLALY 268
           LAGG+ ++++   V  P + V   L  Q         + Y G+ DC+V+I +++G L+ +
Sbjct: 13  LAGGVAAAVSKTAV-APIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFW 71

Query: 269 KGLGPAYLRLGPHTILSMLFWDELRK--LAGRAQHK 302
           +G     +R  P   L+  F D+ ++  L G  +HK
Sbjct: 72  RGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHK 107


>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
          Length = 468

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 53/188 (28%), Positives = 88/188 (46%), Gaps = 17/188 (9%)

Query: 107 VVAGAVAGALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGL 166
           +VAGAVAGA+     +P   +K  +Q           + N   +LG L ++  + G+  L
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHA-------SKTNRLNILGGLRSMVLEGGIRSL 241

Query: 167 WQGVGGAVPRVMVGSAAQLATFASAK-AWVQKQQWLPEDSWLVALAGGMISSIAVVVVMT 225
           W+G G  V ++   SA +   +   K A + +Q+ L      VA   G ++      ++ 
Sbjct: 242 WRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVA---GSLAGATAQTIIY 298

Query: 226 PFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILS 285
           P +V+ TRL      T  R   Y GL DC  +I  +EGP A Y+G  P  L + P+  + 
Sbjct: 299 PMEVLKTRL------TLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGID 352

Query: 286 MLFWDELR 293
           +  ++ L+
Sbjct: 353 LAVYETLK 360



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 71/299 (23%), Positives = 126/299 (42%), Gaps = 34/299 (11%)

Query: 10  LVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGL 69
           LV GA A  ++   T PL+ +K  +Q+      R          +  + ++    G+  L
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNR-------LNILGGLRSMVLEGGIRSL 241

Query: 70  QKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTV----VAGAVAGALGAFVGSPAY 125
            +G    +L     + ++F  Y    +A L QQ    V    VAG++AGA    +  P  
Sbjct: 242 WRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPME 301

Query: 126 LIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQL 185
           ++KT+L  +            ++ +L     I  ++G    ++G    V  ++  +   L
Sbjct: 302 VLKTRLTLRRTG--------QYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDL 353

Query: 186 ATFASAKAWVQKQQWLPEDSW-------LVALAGGMISSIAVVVVMTPFDVVSTRLYNQP 238
           A + + K W     WL + S        LV LA G ISS    +   P  +V TR+  Q 
Sbjct: 354 AVYETLKNW-----WLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQ- 407

Query: 239 VDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAG 297
               G  QL   +   +  I  QEG   LY+G+ P ++++ P   +S + ++ +++  G
Sbjct: 408 ASIEGGPQL--SMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQALG 464



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 49/199 (24%), Positives = 81/199 (40%), Gaps = 21/199 (10%)

Query: 2   ETVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVA 61
           ET+      V G+ A   A     P+EV+KTRL L+   Q        Y G +     + 
Sbjct: 275 ETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQ--------YKGLLDCARRIL 326

Query: 62  RADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQ------QPGGTVV--AGAVA 113
             +G     +G    +L      G+    Y       L Q       PG  V+   G ++
Sbjct: 327 EREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTIS 386

Query: 114 GALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGA 173
              G     P  L++T++QAQ  A++  G Q    ++LG L  I  Q+G+ GL++G+   
Sbjct: 387 STCGQIASYPLALVRTRMQAQ--ASIEGGPQ---LSMLGLLRHILSQEGMRGLYRGIAPN 441

Query: 174 VPRVMVGSAAQLATFASAK 192
             +V+   +     + + K
Sbjct: 442 FMKVIPAVSISYVVYENMK 460


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,552,394
Number of Sequences: 37866
Number of extensions: 479431
Number of successful extensions: 1527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1034
Number of HSP's gapped (non-prelim): 191
length of query: 304
length of database: 18,247,518
effective HSP length: 102
effective length of query: 202
effective length of database: 14,385,186
effective search space: 2905807572
effective search space used: 2905807572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.