BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens] (390 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens] 798 0.0 gi|55749544 SH3 multiple domains 1 [Homo sapiens] 208 8e-54 gi|63055059 SH3 and PX domains 2B [Homo sapiens] 207 1e-53 gi|41281828 NADPH oxidase organizer 1 isoform c [Homo sapiens] 106 3e-23 gi|41281811 NADPH oxidase organizer 1 isoform b [Homo sapiens] 106 3e-23 gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens] 102 6e-22 gi|239752628 PREDICTED: hypothetical protein XP_002347816 [Homo ... 85 1e-16 gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 73 4e-13 gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 73 4e-13 gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 73 4e-13 gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 63 5e-10 gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 63 5e-10 gi|47519798 neutrophil cytosolic factor 4 isoform 1 [Homo sapiens] 58 2e-08 gi|163644267 neutrophil cytosolic factor 4 isoform 2 [Homo sapiens] 58 2e-08 gi|20149528 proline-serine-threonine phosphatase interacting pro... 57 3e-08 gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 55 8e-08 gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sap... 54 2e-07 gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo sap... 54 2e-07 gi|11321634 CD2-associated protein [Homo sapiens] 51 2e-06 gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 51 2e-06 gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 51 2e-06 gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 51 2e-06 gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 51 2e-06 gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 51 2e-06 gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 51 2e-06 gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 51 2e-06 gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 51 2e-06 gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 50 3e-06 gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 50 3e-06 gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 50 3e-06 >gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens] Length = 390 Score = 798 bits (2061), Expect = 0.0 Identities = 390/390 (100%), Positives = 390/390 (100%) Query: 1 MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60 MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI Sbjct: 1 MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 60 Query: 61 EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKV 120 EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKV Sbjct: 61 EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKV 120 Query: 121 RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG 180 RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG Sbjct: 121 RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG 180 Query: 181 DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV 240 DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV Sbjct: 181 DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV 240 Query: 241 EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP 300 EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP Sbjct: 241 EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP 300 Query: 301 RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK 360 RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK Sbjct: 301 RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK 360 Query: 361 PQPAVPPRPSADLILNRCSESTKRKLASAV 390 PQPAVPPRPSADLILNRCSESTKRKLASAV Sbjct: 361 PQPAVPPRPSADLILNRCSESTKRKLASAV 390 >gi|55749544 SH3 multiple domains 1 [Homo sapiens] Length = 1105 Score = 208 bits (529), Expect = 8e-54 Identities = 106/301 (35%), Positives = 171/301 (56%), Gaps = 12/301 (3%) Query: 6 IRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAI 65 ++ ++ EKR PS+HYVY+ V W D + + +YRR+++ ++ L + FPIE G Sbjct: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQK 65 Query: 66 NPENRIIPHLPAPKWFDGQR---AAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRP 122 +P+ RIIP LP F A R + EYC L+ LP IS+C + FF+ RP Sbjct: 66 DPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARP 125 Query: 123 DDLKLPTDNQ-TKKPETYLMPKDGKSTATDITG------PIILQTYRAIANYEKTSGSEM 175 +D+ P ++ + K ++ + +S D+TG P+IL+ Y ++NY+K SE+ Sbjct: 126 EDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSEL 185 Query: 176 ALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAG--EPYVA 233 +L G+VV+V+EK+ESGWWF ++GW+PA++LE + + D + G E YV Sbjct: 186 SLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVT 245 Query: 234 IKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQ 293 ++ YT+ DE+ +G VEVI K L+GWW IR G+ P+ YL+K+ D+ ++ Sbjct: 246 VQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKN 305 Query: 294 I 294 + Sbjct: 306 L 306 Score = 53.9 bits (128), Expect = 2e-07 Identities = 24/66 (36%), Positives = 37/66 (56%), Gaps = 4/66 (6%) Query: 160 TYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDET 219 +Y + Y+K SE++ G V+V+EK ESGWW+ + GW P+ +L DE Sbjct: 816 SYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL----VLDEN 871 Query: 220 EDPEPN 225 E P+P+ Sbjct: 872 EQPDPS 877 Score = 50.4 bits (119), Expect = 3e-06 Identities = 23/99 (23%), Positives = 43/99 (43%) Query: 119 KVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALS 178 ++ P ++ + N +P G P + Y IA ++ ++ Sbjct: 383 RIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFR 442 Query: 179 TGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPD 217 G EV++K+ GWW+ Q+ K GW PAS+++ P+ Sbjct: 443 GGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPN 481 Score = 45.8 bits (107), Expect = 7e-05 Identities = 22/58 (37%), Positives = 40/58 (68%), Gaps = 11/58 (18%) Query: 161 YRAIANYE---KTSGSEMALSTGDVVEVVEKSESGWWFCQ----MKAKRGWIPASFLE 211 Y +IA+YE +T+G + +S +EV+E++ +GWW+CQ +K +GW+P+++LE Sbjct: 1049 YVSIADYEGDEETAGFQEGVS----MEVLERNPNGWWYCQILDGVKPFKGWVPSNYLE 1102 Score = 44.7 bits (104), Expect = 1e-04 Identities = 23/69 (33%), Positives = 34/69 (49%), Gaps = 5/69 (7%) Query: 212 PLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDV 271 P + E E P +Y + AY V+ E+S G V+V+ K GWW +R ++ Sbjct: 803 PCPTKKEWEGPATSY-----MTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGEL 857 Query: 272 TGYFPSMYL 280 G+ PS YL Sbjct: 858 EGWAPSHYL 866 Score = 43.5 bits (101), Expect = 3e-04 Identities = 40/162 (24%), Positives = 69/162 (42%), Gaps = 11/162 (6%) Query: 222 PEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281 PEP Y I + + D +S G+ EVI K GWW ++ + G+ P+ Y+ Sbjct: 416 PEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYID 475 Query: 282 KSGQ-DVSQAQRQIKR-GAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQA 339 K + ++S+ + R PP + + + SQD+ R+ +++ + Sbjct: 476 KRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRK--LKYEEPEYDIP 533 Query: 340 RPG----PQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNR 377 G P+ P+E+ +R +PA P RPS L R Sbjct: 534 AFGFDSEPELSEEPVEDRASGER---RPAQPHRPSPASSLQR 572 Score = 38.9 bits (89), Expect = 0.008 Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 11/91 (12%) Query: 198 MKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDE--VSLLEGEAVEV 255 + A+R IP S + P P E N + YV+I Y EGDE EG ++EV Sbjct: 1018 LPAQRNSIPVSPVRP--KPIEKSQFIHNNLKDVYVSIADY---EGDEETAGFQEGVSMEV 1072 Query: 256 IHKLLDGWWVIRKDD----VTGYFPSMYLQK 282 + + +GWW + D G+ PS YL+K Sbjct: 1073 LERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103 >gi|63055059 SH3 and PX domains 2B [Homo sapiens] Length = 911 Score = 207 bits (527), Expect = 1e-53 Identities = 133/381 (34%), Positives = 196/381 (51%), Gaps = 37/381 (9%) Query: 6 IRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAI 65 I + +L +KR VP++HYVY+ V W S + +YRR+++ ++ + + FP+E G Sbjct: 7 IVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQK 66 Query: 66 NPENRIIPHLPAPKWFDGQR---AAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRP 122 +P+ RIIP LP F A R + EYC L+ LP IS+C +L FF+ RP Sbjct: 67 DPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRP 126 Query: 123 DDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDV 182 +DL P + K ++ G T+ D P++L+ Y +ANY+K SE++LS G V Sbjct: 127 EDLNPPKEEHIGKKKS-----GGDQTSVD---PMVLEQYVVVANYQKQESSEISLSVGQV 178 Query: 183 VEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEG 242 V+++EK+ESGWWF ++GW+PA+ LE D + +P E Y I YTA + Sbjct: 179 VDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE-EEEKYTVIYPYTARDQ 237 Query: 243 DEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK-SGQDVSQAQRQIKRGAPPR 301 DE++L G VEVI K L+GWW IR G+ P+ YL+K SG+ + K G P Sbjct: 238 DEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPP-----KPG--PG 290 Query: 302 RSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQR--RRQARPGPQSPG---SPLEEERQT 356 S A + SR+ Q+A R QR R + RP P SP +R Sbjct: 291 SPSHPGALDLDGVSRQ---QNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPP 347 Query: 357 QR---------SKPQPAVPPR 368 R + P+P +PP+ Sbjct: 348 PRRDMTIPRGLNLPKPPIPPQ 368 Score = 65.5 bits (158), Expect = 8e-11 Identities = 54/225 (24%), Positives = 95/225 (42%), Gaps = 25/225 (11%) Query: 155 PIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLD 214 P + + Y IA ++ T ++ G VEV+EK+ SGWW+ Q++ K GW PA+F++ Sbjct: 367 PQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYK 426 Query: 215 SPDETEDPE---PNYAGEPYVAIKAYTAVEGDEVSLLEGEA---VEVIHKLLDG---W-- 263 P P + + A+E + S G + + H ++D W Sbjct: 427 KTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSK 486 Query: 264 -WVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSS-IRNAHSIHQRSRKRLSQ 321 W KD + M +++S + K PPR+ S I++ + +R R+R Sbjct: 487 DWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRT 546 Query: 322 DAYRRNSVRFLQQRRRQARPG---PQSPGSPLEEERQTQRSKPQP 363 + R + + PG P P + R ++R +P+P Sbjct: 547 EQLRGPTPK---------PPGVILPMMPAKHIPPARDSRRPEPKP 582 Score = 45.4 bits (106), Expect = 9e-05 Identities = 32/125 (25%), Positives = 52/125 (41%), Gaps = 14/125 (11%) Query: 222 PEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281 P P E Y I + D +S G VEVI K L GWW I+ +D G+ P+ ++ Sbjct: 364 PIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFID 423 Query: 282 KSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARP 341 K + + ++ P H+ ++ RL + A N+ + +RP Sbjct: 424 KYKKTSNASRPNFLAPLP------------HEVTQLRLGEAAALENNTG--SEATGPSRP 469 Query: 342 GPQSP 346 P +P Sbjct: 470 LPDAP 474 Score = 45.4 bits (106), Expect = 9e-05 Identities = 22/54 (40%), Positives = 33/54 (61%), Gaps = 5/54 (9%) Query: 161 YRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQM----KAKRGWIPASFL 210 Y A+A++E + + G V EV EK+ SGWWFCQ+ + GWIP+++L Sbjct: 855 YVAVADFEGDKDTS-SFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL 907 >gi|41281828 NADPH oxidase organizer 1 isoform c [Homo sapiens] Length = 376 Score = 106 bits (265), Expect = 3e-23 Identities = 92/376 (24%), Positives = 152/376 (40%), Gaps = 62/376 (16%) Query: 26 YMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQ- 84 + F V+W D S+ V R + E + KTLKE FP+EAG + +R++P L D Sbjct: 24 FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASLDAPL 83 Query: 85 --RAAENRQG-----TLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLK--LPTDNQTKK 135 R +G L Y L++ +++R P + FF +P DL+ LP ++ Sbjct: 84 LGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVIL 143 Query: 136 PETYLMPKDGKSTATDITGPIILQTYRAIANY--EKTSGSEMALSTGDVVEVVEKSESGW 193 P P + I + Q+ R + + + T + ++V+ + SGW Sbjct: 144 PTPEEQPLSRAAGRLSIHS-LEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGW 202 Query: 194 WFCQMKAKR-GWIPASFLEPLDSPDETEDPEPNY--AGEPYVAIKAYTAVEGDEVSLLEG 250 W + + ++ W PA +LE +P + + P+ +G + A +AY + DE+S+ G Sbjct: 203 WLVENEDRQTAWFPAPYLEEA-APGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAG 261 Query: 251 EAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHS 310 V V+ GWW+ R D G P++ L+ G + + G P Sbjct: 262 ARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDP---------- 311 Query: 311 IHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPS 370 +AR P+ +Q + P P VP RPS Sbjct: 312 -------------------------AGEARGFPE----------PSQATAPPPTVPTRPS 336 Query: 371 ADLILNRCSESTKRKL 386 I +RC T+R L Sbjct: 337 PGAIQSRCCTVTRRAL 352 >gi|41281811 NADPH oxidase organizer 1 isoform b [Homo sapiens] Length = 371 Score = 106 bits (265), Expect = 3e-23 Identities = 93/371 (25%), Positives = 153/371 (41%), Gaps = 57/371 (15%) Query: 26 YMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPH-LPAPKWFDGQ 84 + F V+W D S+ V R + E + KTLKE FP+EAG + +R++P L AP Sbjct: 24 FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLDAPLLGRVG 83 Query: 85 RAAEN--RQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLK--LPTDNQTKKPETYL 140 R + R L Y L++ +++R P + FF +P DL+ LP ++ P Sbjct: 84 RTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEE 143 Query: 141 MPKDGKSTATDITGPIILQTYRAIANY--EKTSGSEMALSTGDVVEVVEKSESGWWFCQM 198 P + I + Q+ R + + + T + ++V+ + SGWW + Sbjct: 144 QPLSRAAGRLSIHS-LEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVEN 202 Query: 199 KAKR-GWIPASFLEPLDSPDETEDPEPNY--AGEPYVAIKAYTAVEGDEVSLLEGEAVEV 255 + ++ W PA +LE +P + + P+ +G + A +AY + DE+S+ G V V Sbjct: 203 EDRQTAWFPAPYLEEA-APGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRV 261 Query: 256 IHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRS 315 + GWW+ R D G P++ L+ G + + G P Sbjct: 262 LETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDP--------------- 306 Query: 316 RKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLIL 375 +AR P+ +Q + P P VP RPS I Sbjct: 307 --------------------AGEARGFPE----------PSQATAPPPTVPTRPSPGAIQ 336 Query: 376 NRCSESTKRKL 386 +RC T+R L Sbjct: 337 SRCCTVTRRAL 347 >gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens] Length = 370 Score = 102 bits (254), Expect = 6e-22 Identities = 93/371 (25%), Positives = 153/371 (41%), Gaps = 58/371 (15%) Query: 26 YMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHL-PAPKWFDGQ 84 + F V+W D S+ V R + E + KTLKE FP+EAG + +R++P L AP Sbjct: 24 FAFSVRWSDGSDTFVRRSWDEFRQL-KTLKETFPVEAGLLRRSDRVLPKLLDAPLLGRVG 82 Query: 85 RAAEN--RQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLK--LPTDNQTKKPETYL 140 R + R L Y L++ +++R P + FF +P DL+ LP ++ P Sbjct: 83 RTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEE 142 Query: 141 MPKDGKSTATDITGPIILQTYRAIANY--EKTSGSEMALSTGDVVEVVEKSESGWWFCQM 198 P + I + Q+ R + + + T + ++V+ + SGWW + Sbjct: 143 QPLSRAAGRLSIHS-LEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVEN 201 Query: 199 KAKR-GWIPASFLEPLDSPDETEDPEPNY--AGEPYVAIKAYTAVEGDEVSLLEGEAVEV 255 + ++ W PA +LE +P + + P+ +G + A +AY + DE+S+ G V V Sbjct: 202 EDRQTAWFPAPYLEEA-APGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRV 260 Query: 256 IHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRS 315 + GWW+ R D G P++ L+ G + + G P Sbjct: 261 LETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDP--------------- 305 Query: 316 RKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLIL 375 +AR P+ +Q + P P VP RPS I Sbjct: 306 --------------------AGEARGFPE----------PSQATAPPPTVPTRPSPGAIQ 335 Query: 376 NRCSESTKRKL 386 +RC T+R L Sbjct: 336 SRCCTVTRRAL 346 >gi|239752628 PREDICTED: hypothetical protein XP_002347816 [Homo sapiens] Length = 164 Score = 84.7 bits (208), Expect = 1e-16 Identities = 43/44 (97%), Positives = 43/44 (97%) Query: 149 ATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESG 192 A DITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESG Sbjct: 35 APDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESG 78 Score = 31.2 bits (69), Expect = 1.7 Identities = 28/104 (26%), Positives = 39/104 (37%), Gaps = 12/104 (11%) Query: 205 IPASFLEPLDSPDETEDPE----PNYAG----EPYVAIKAYTAVEGDEVSLLEGEAVEVI 256 +PA LE P P P+ G + Y AI Y G E++L G+ VEV+ Sbjct: 13 MPAPVLEAQMGPAMPTHPALPLAPDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVV 72 Query: 257 HKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP 300 K G + +TG P + Q Q + G P Sbjct: 73 EKSESG----QTSHLTGLLPLVLRNPQPQAPCQGSGSLAPGRTP 112 >gi|194294523 intersectin 2 isoform 3 [Homo sapiens] Length = 1670 Score = 73.2 bits (178), Expect = 4e-13 Identities = 48/169 (28%), Positives = 84/169 (49%), Gaps = 20/169 (11%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPD-ETE 220 +A+ ++ + + S D++ V+E+ E+ WWF ++ RGW P S+++ + + + E Sbjct: 877 QALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKRE 935 Query: 221 DPEPNYA-------------GEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDG-WWVI 266 +PE YA GE Y+A+ Y++VE +++ EGE + V K DG WW Sbjct: 936 EPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK--DGEWWTG 993 Query: 267 RKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRS 315 D +G FPS Y++ Q+ + K GA ++ I S + S Sbjct: 994 SIGDRSGIFPSNYVKPKDQESFGSAS--KSGASNKKPEIAQVTSAYVAS 1040 Score = 70.9 bits (172), Expect = 2e-12 Identities = 45/157 (28%), Positives = 79/157 (50%), Gaps = 15/157 (9%) Query: 136 PETYLMPKDGKS------TATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKS 189 P Y+ PKD +S + P I Q A Y + +++L+ G ++ +++K+ Sbjct: 1003 PSNYVKPKDQESFGSASKSGASNKKPEIAQVTSA---YVASGSEQLSLAPGQLILILKKN 1059 Query: 190 ESGWWFCQMKAK-----RGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDE 244 SGWW +++A+ +GW PAS ++ L E P + + +A+ Y A DE Sbjct: 1060 TSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQ-VIAMYDYAANNEDE 1118 Query: 245 VSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281 +S +G+ + V++K WW + VTG FPS Y++ Sbjct: 1119 LSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155 Score = 53.1 bits (126), Expect = 4e-07 Identities = 32/130 (24%), Positives = 64/130 (49%), Gaps = 9/130 (6%) Query: 119 KVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALS 178 K++ ++ K + Q K +T + + TA+ +L YRA+ +E + EM+ + Sbjct: 700 KIQEEERKAE-EKQRKDKDTLKAEEKKRETAS------VLVNYRALYPFEARNHDEMSFN 752 Query: 179 TGDVVEVVEKS--ESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKA 236 +GD+++V EK+ E GW + + GW P +++E + S + + P A P + Sbjct: 753 SGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLS 812 Query: 237 YTAVEGDEVS 246 T+ + +S Sbjct: 813 ATSTSSEPLS 822 >gi|194294521 intersectin 2 isoform 1 [Homo sapiens] Length = 1697 Score = 73.2 bits (178), Expect = 4e-13 Identities = 48/169 (28%), Positives = 84/169 (49%), Gaps = 20/169 (11%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPD-ETE 220 +A+ ++ + + S D++ V+E+ E+ WWF ++ RGW P S+++ + + + E Sbjct: 904 QALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKRE 962 Query: 221 DPEPNYA-------------GEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDG-WWVI 266 +PE YA GE Y+A+ Y++VE +++ EGE + V K DG WW Sbjct: 963 EPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK--DGEWWTG 1020 Query: 267 RKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRS 315 D +G FPS Y++ Q+ + K GA ++ I S + S Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSAS--KSGASNKKPEIAQVTSAYVAS 1067 Score = 70.9 bits (172), Expect = 2e-12 Identities = 45/157 (28%), Positives = 79/157 (50%), Gaps = 15/157 (9%) Query: 136 PETYLMPKDGKS------TATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKS 189 P Y+ PKD +S + P I Q A Y + +++L+ G ++ +++K+ Sbjct: 1030 PSNYVKPKDQESFGSASKSGASNKKPEIAQVTSA---YVASGSEQLSLAPGQLILILKKN 1086 Query: 190 ESGWWFCQMKAK-----RGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDE 244 SGWW +++A+ +GW PAS ++ L E P + + +A+ Y A DE Sbjct: 1087 TSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQ-VIAMYDYAANNEDE 1145 Query: 245 VSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281 +S +G+ + V++K WW + VTG FPS Y++ Sbjct: 1146 LSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182 Score = 53.1 bits (126), Expect = 4e-07 Identities = 32/130 (24%), Positives = 64/130 (49%), Gaps = 9/130 (6%) Query: 119 KVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALS 178 K++ ++ K + Q K +T + + TA+ +L YRA+ +E + EM+ + Sbjct: 727 KIQEEERKAE-EKQRKDKDTLKAEEKKRETAS------VLVNYRALYPFEARNHDEMSFN 779 Query: 179 TGDVVEVVEKS--ESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKA 236 +GD+++V EK+ E GW + + GW P +++E + S + + P A P + Sbjct: 780 SGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLS 839 Query: 237 YTAVEGDEVS 246 T+ + +S Sbjct: 840 ATSTSSEPLS 849 >gi|194294525 intersectin 2 isoform 2 [Homo sapiens] Length = 1249 Score = 73.2 bits (178), Expect = 4e-13 Identities = 48/169 (28%), Positives = 84/169 (49%), Gaps = 20/169 (11%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPD-ETE 220 +A+ ++ + + S D++ V+E+ E+ WWF ++ RGW P S+++ + + + E Sbjct: 904 QALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKRE 962 Query: 221 DPEPNYA-------------GEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDG-WWVI 266 +PE YA GE Y+A+ Y++VE +++ EGE + V K DG WW Sbjct: 963 EPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK--DGEWWTG 1020 Query: 267 RKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRS 315 D +G FPS Y++ Q+ + K GA ++ I S + S Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSAS--KSGASNKKPEIAQVTSAYVAS 1067 Score = 70.9 bits (172), Expect = 2e-12 Identities = 45/157 (28%), Positives = 79/157 (50%), Gaps = 15/157 (9%) Query: 136 PETYLMPKDGKS------TATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKS 189 P Y+ PKD +S + P I Q A Y + +++L+ G ++ +++K+ Sbjct: 1030 PSNYVKPKDQESFGSASKSGASNKKPEIAQVTSA---YVASGSEQLSLAPGQLILILKKN 1086 Query: 190 ESGWWFCQMKAK-----RGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDE 244 SGWW +++A+ +GW PAS ++ L E P + + +A+ Y A DE Sbjct: 1087 TSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQ-VIAMYDYAANNEDE 1145 Query: 245 VSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281 +S +G+ + V++K WW + VTG FPS Y++ Sbjct: 1146 LSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182 Score = 53.1 bits (126), Expect = 4e-07 Identities = 32/130 (24%), Positives = 64/130 (49%), Gaps = 9/130 (6%) Query: 119 KVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALS 178 K++ ++ K + Q K +T + + TA+ +L YRA+ +E + EM+ + Sbjct: 727 KIQEEERKAE-EKQRKDKDTLKAEEKKRETAS------VLVNYRALYPFEARNHDEMSFN 779 Query: 179 TGDVVEVVEKS--ESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKA 236 +GD+++V EK+ E GW + + GW P +++E + S + + P A P + Sbjct: 780 SGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLS 839 Query: 237 YTAVEGDEVS 246 T+ + +S Sbjct: 840 ATSTSSEPLS 849 >gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] Length = 1220 Score = 62.8 bits (151), Expect = 5e-10 Identities = 41/160 (25%), Positives = 77/160 (48%), Gaps = 14/160 (8%) Query: 136 PETYLMPKDGKSTAT-DITGPIIL--QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESG 192 P Y+ KD + + T TG + + + IA+Y T ++ L+ G ++ + +K+ G Sbjct: 1051 PSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGG 1110 Query: 193 WWFCQMKAKR-----GWIPASFLEPLD------SPDETEDPEPNYAGEPYVAIKAYTAVE 241 WW +++A+ GW PA++++ L +P E A + + YTA Sbjct: 1111 WWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQN 1170 Query: 242 GDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281 DE++ +G+ + V++K WW + G FPS Y++ Sbjct: 1171 DDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210 Score = 58.2 bits (139), Expect = 1e-08 Identities = 34/141 (24%), Positives = 68/141 (48%), Gaps = 24/141 (17%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSP----- 216 +A+ + + + + DV+ V+E+ + WWF +++ ++GW P S+++ + P Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKST 977 Query: 217 ----DETEDP-----------EPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLD 261 +E P +P +GE ++A+ Y + E +++ +G+ + V K D Sbjct: 978 SMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK--D 1035 Query: 262 G-WWVIRKDDVTGYFPSMYLQ 281 G WW D G FPS Y++ Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVR 1056 Score = 53.9 bits (128), Expect = 2e-07 Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 14/173 (8%) Query: 142 PKDGKSTATDITGPIIL-QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA 200 P K A+ P++ + + A+ YE + ++ GDV+ +V K + WW + Sbjct: 987 PASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGD 1045 Query: 201 KRGWIPASFLEPLDSPDE-TEDPEPNYAGEPYVA--IKAYTAVEGDEVSLLEGEAVEVIH 257 K G P++++ DS T + +P +A I +YTA ++++L G+ + + Sbjct: 1046 KAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRK 1105 Query: 258 KLLDGWW-----VIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSI 305 K GWW K G+FP+ Y++ +S +I PP+ +++ Sbjct: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKL----LSPGTSKITPTEPPKSTAL 1154 Score = 43.5 bits (101), Expect = 3e-04 Identities = 26/71 (36%), Positives = 38/71 (53%), Gaps = 10/71 (14%) Query: 161 YRAIANYEKTSGSEMALSTGDVVEV----VEKS---ESGWWFCQMKAKRGWIPASFLEPL 213 YRA+ +E S E+ + GD+V V V++S E GW ++K K GW PA++ E + Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804 Query: 214 DSPDETEDPEP 224 E E P P Sbjct: 805 ---PENEVPAP 812 Score = 33.1 bits (74), Expect = 0.44 Identities = 11/55 (20%), Positives = 29/55 (52%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE 220 +Y + E+A + G ++ V+ K + WW ++ + G P+++++ D ++ Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219 >gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] Length = 1721 Score = 62.8 bits (151), Expect = 5e-10 Identities = 41/160 (25%), Positives = 77/160 (48%), Gaps = 14/160 (8%) Query: 136 PETYLMPKDGKSTAT-DITGPIIL--QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESG 192 P Y+ KD + + T TG + + + IA+Y T ++ L+ G ++ + +K+ G Sbjct: 1051 PSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGG 1110 Query: 193 WWFCQMKAKR-----GWIPASFLEPLD------SPDETEDPEPNYAGEPYVAIKAYTAVE 241 WW +++A+ GW PA++++ L +P E A + + YTA Sbjct: 1111 WWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQN 1170 Query: 242 GDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281 DE++ +G+ + V++K WW + G FPS Y++ Sbjct: 1171 DDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210 Score = 58.2 bits (139), Expect = 1e-08 Identities = 34/141 (24%), Positives = 68/141 (48%), Gaps = 24/141 (17%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSP----- 216 +A+ + + + + DV+ V+E+ + WWF +++ ++GW P S+++ + P Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKST 977 Query: 217 ----DETEDP-----------EPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLD 261 +E P +P +GE ++A+ Y + E +++ +G+ + V K D Sbjct: 978 SMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK--D 1035 Query: 262 G-WWVIRKDDVTGYFPSMYLQ 281 G WW D G FPS Y++ Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVR 1056 Score = 53.9 bits (128), Expect = 2e-07 Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 14/173 (8%) Query: 142 PKDGKSTATDITGPIIL-QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA 200 P K A+ P++ + + A+ YE + ++ GDV+ +V K + WW + Sbjct: 987 PASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGD 1045 Query: 201 KRGWIPASFLEPLDSPDE-TEDPEPNYAGEPYVA--IKAYTAVEGDEVSLLEGEAVEVIH 257 K G P++++ DS T + +P +A I +YTA ++++L G+ + + Sbjct: 1046 KAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRK 1105 Query: 258 KLLDGWW-----VIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSI 305 K GWW K G+FP+ Y++ +S +I PP+ +++ Sbjct: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKL----LSPGTSKITPTEPPKSTAL 1154 Score = 43.5 bits (101), Expect = 3e-04 Identities = 26/71 (36%), Positives = 38/71 (53%), Gaps = 10/71 (14%) Query: 161 YRAIANYEKTSGSEMALSTGDVVEV----VEKS---ESGWWFCQMKAKRGWIPASFLEPL 213 YRA+ +E S E+ + GD+V V V++S E GW ++K K GW PA++ E + Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804 Query: 214 DSPDETEDPEP 224 E E P P Sbjct: 805 ---PENEVPAP 812 Score = 33.1 bits (74), Expect = 0.44 Identities = 11/55 (20%), Positives = 29/55 (52%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE 220 +Y + E+A + G ++ V+ K + WW ++ + G P+++++ D ++ Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219 >gi|47519798 neutrophil cytosolic factor 4 isoform 1 [Homo sapiens] Length = 339 Score = 57.8 bits (138), Expect = 2e-08 Identities = 56/212 (26%), Positives = 98/212 (46%), Gaps = 10/212 (4%) Query: 15 EKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPH 74 EKR S H+V++ VK + S+ ++YRR+ + + L+E F ++ + + +P Sbjct: 31 EKRGFTS-HFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKS-SALACTLPT 88 Query: 75 LPAPKWFD-GQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRP-DDLKLPTDNQ 132 LPA + Q AE R L Y +L+SLP + + FF P D ++P + Sbjct: 89 LPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALR 148 Query: 133 TKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALS--TGDVVEVVEKSE 190 +P T + KS + + RA A ++ T S++ L+ GDV+ ++ + Sbjct: 149 RLRPRT----RKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRIN 204 Query: 191 SGWWFCQMKAKRGWIPASFLEPLDSPDETEDP 222 W ++ G P SF++ L E +DP Sbjct: 205 KDWLEGTVRGATGIFPLSFVKILKDFPEEDDP 236 >gi|163644267 neutrophil cytosolic factor 4 isoform 2 [Homo sapiens] Length = 348 Score = 57.8 bits (138), Expect = 2e-08 Identities = 56/212 (26%), Positives = 98/212 (46%), Gaps = 10/212 (4%) Query: 15 EKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPH 74 EKR S H+V++ VK + S+ ++YRR+ + + L+E F ++ + + +P Sbjct: 31 EKRGFTS-HFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKS-SALACTLPT 88 Query: 75 LPAPKWFD-GQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRP-DDLKLPTDNQ 132 LPA + Q AE R L Y +L+SLP + + FF P D ++P + Sbjct: 89 LPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALR 148 Query: 133 TKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALS--TGDVVEVVEKSE 190 +P T + KS + + RA A ++ T S++ L+ GDV+ ++ + Sbjct: 149 RLRPRT----RKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRIN 204 Query: 191 SGWWFCQMKAKRGWIPASFLEPLDSPDETEDP 222 W ++ G P SF++ L E +DP Sbjct: 205 KDWLEGTVRGATGIFPLSFVKILKDFPEEDDP 236 >gi|20149528 proline-serine-threonine phosphatase interacting protein 1 [Homo sapiens] Length = 416 Score = 57.0 bits (136), Expect = 3e-08 Identities = 23/55 (41%), Positives = 36/55 (65%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPL 213 Q YRA+ +Y + E+ LS GD++EV+ + E GWW + +RG++P S+LE L Sbjct: 362 QEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEKL 416 Score = 48.5 bits (114), Expect = 1e-05 Identities = 22/59 (37%), Positives = 33/59 (55%) Query: 224 PNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P + Y A+ YTA DE+ L G+ +EVI + DGWW + ++ G+ P YL+K Sbjct: 357 PASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEK 415 >gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo sapiens] Length = 756 Score = 55.5 bits (132), Expect = 8e-08 Identities = 38/145 (26%), Positives = 61/145 (42%), Gaps = 30/145 (20%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDS-------PDE 218 +Y E+ L G++VE++++ E GWW + + G P++F+E LDS PD Sbjct: 93 SYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDM 152 Query: 219 TE----------------DPEPNYA-----GEPYVAIKAYTAVEGDEVSLLEGEAVEVIH 257 D P+Y E Y + Y DE++L G+ V+V+ Sbjct: 153 PSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLS 212 Query: 258 KLLD--GWWVIRKDDVTGYFPSMYL 280 K + GWW G FP ++ Sbjct: 213 KTTEDKGWWEGECQGRRGVFPDNFV 237 Score = 50.4 bits (119), Expect = 3e-06 Identities = 38/133 (28%), Positives = 59/133 (44%), Gaps = 15/133 (11%) Query: 164 IANYEKTSGSEMALSTGDVVEVVEKSES-GWWFCQMKAKRGWIPASFL----EPLDSPDE 218 +A Y E++L+ GDVV V + GW + + G P + E L E Sbjct: 6 LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGE 65 Query: 219 TEDPE-------PNYAGEPYVAIK---AYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRK 268 P P P K +Y+ + DE+ L GE VE+I ++ DGWW+ +K Sbjct: 66 ARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125 Query: 269 DDVTGYFPSMYLQ 281 + G FPS +++ Sbjct: 126 NGQLGAFPSNFVE 138 Score = 48.9 bits (115), Expect = 8e-06 Identities = 46/211 (21%), Positives = 84/211 (39%), Gaps = 24/211 (11%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKS--ESGWWFCQMKAKRGWIPASFLEPLDSP 216 + YR + +Y+ + E+AL GDVV+V+ K+ + GWW + + +RG P +F+ P Sbjct: 184 EVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLP---- 239 Query: 217 DETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFP 276 P P P + +A + L+ ++ + KL TG Sbjct: 240 -----PPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATA--------TTGPSK 286 Query: 277 SMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRR 336 + + +D +Q+ R + P ++ S H RKR ++ SV ++ Sbjct: 287 AKTSRTPSRD---SQKLTSRDSGP-NGGFQSGGSYHP-GRKRSKTQTPQQRSVSSQEEEH 341 Query: 337 RQARPGPQSPGSPLEEERQTQRSKPQPAVPP 367 P +P+ ++ T P P P Sbjct: 342 SSPVKAPSVKRTPMPDKTATPERPPAPENAP 372 >gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sapiens] Length = 506 Score = 54.3 bits (129), Expect = 2e-07 Identities = 28/103 (27%), Positives = 47/103 (45%) Query: 113 HLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSG 172 H + K+ L +N K + G ST + + +A+ +++ Sbjct: 395 HTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQD 454 Query: 173 SEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDS 215 E+ L GD+V + EK E GWWF + K+G PA+++E L S Sbjct: 455 DELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPS 497 Score = 36.6 bits (83), Expect = 0.040 Identities = 15/50 (30%), Positives = 31/50 (62%) Query: 233 AIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 A+ ++ A + DE++L +G+ V + K +GWW + G+FP+ Y+++ Sbjct: 445 ALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEE 494 >gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo sapiens] Length = 428 Score = 54.3 bits (129), Expect = 2e-07 Identities = 28/103 (27%), Positives = 47/103 (45%) Query: 113 HLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSG 172 H + K+ L +N K + G ST + + +A+ +++ Sbjct: 317 HTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQD 376 Query: 173 SEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDS 215 E+ L GD+V + EK E GWWF + K+G PA+++E L S Sbjct: 377 DELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEELPS 419 Score = 36.6 bits (83), Expect = 0.040 Identities = 15/50 (30%), Positives = 31/50 (62%) Query: 233 AIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 A+ ++ A + DE++L +G+ V + K +GWW + G+FP+ Y+++ Sbjct: 367 ALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEE 416 >gi|11321634 CD2-associated protein [Homo sapiens] Length = 639 Score = 51.2 bits (121), Expect = 2e-06 Identities = 54/183 (29%), Positives = 80/183 (43%), Gaps = 26/183 (14%) Query: 92 GTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPT---DNQTKKPETYLM-----PK 143 G ++E ++ P KI R D FK L+ T + + KKPE L+ PK Sbjct: 195 GNVSETASGSVTQPKKI-RGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPK 253 Query: 144 DG--KSTATDITGPIILQTY-RAIANYEKTSGSEMALSTGDVVEVVEKS--ESGWWFCQM 198 + T TD G I + Y R + YE T+ E+ G+++ ++ K E+GWW ++ Sbjct: 254 TQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGEL 313 Query: 199 KAKRGWIPASFLEPL-----DSPDETEDPEPNYAGEP----YVAIKAYTAV---EGDEVS 246 K G P +F + D P + P P A P A K Y ++ E DE S Sbjct: 314 NGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKS 373 Query: 247 LLE 249 LE Sbjct: 374 TLE 376 Score = 45.1 bits (105), Expect = 1e-04 Identities = 20/72 (27%), Positives = 37/72 (51%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETED 221 + + Y + E+ L GD++++ E+ E GWW + K G P++F++ L+ D+ E Sbjct: 114 KVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGET 173 Query: 222 PEPNYAGEPYVA 233 E E +A Sbjct: 174 HEAQDDSETVLA 185 Score = 40.4 bits (93), Expect = 0.003 Identities = 29/156 (18%), Positives = 61/156 (39%), Gaps = 39/156 (25%) Query: 166 NYEKTSGSEMALSTGDVVEVVEK-SESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPE- 223 +Y+ E+ + G+++ V+K E GW ++ +RG P +F++ + E +D Sbjct: 9 DYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSL 68 Query: 224 ----------------------PNYAGEPYVAIK---------------AYTAVEGDEVS 246 P +P+ K Y DE+ Sbjct: 69 PIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELE 128 Query: 247 LLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 L G+ +++ ++ +GWW ++ G FPS ++++ Sbjct: 129 LKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKE 164 Score = 33.9 bits (76), Expect = 0.26 Identities = 34/145 (23%), Positives = 59/145 (40%), Gaps = 13/145 (8%) Query: 236 AYTAVEGDEVSLLEGEAVEVIHKLLD--GWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQ 293 AY DE++ EGE + +I K GWW + G FP + + ++ + + Sbjct: 279 AYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI-NELDKDFPK 337 Query: 294 IKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQR-RRQARP--GPQSPGSPL 350 K+ PP ++ I +K S ++ L+Q+ + A P P+ P P Sbjct: 338 PKKPPPPAKAPAPKPELI-AAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPT 396 Query: 351 EEERQTQRS------KPQPAVPPRP 369 + + S +P+ VPP P Sbjct: 397 KASNLLRSSGTVYPKRPEKPVPPPP 421 >gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo sapiens] Length = 492 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 8/164 (4%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE- 220 +A+ +++ + E++ GD V ++ K + W+ + + G P S++E L P++ + Sbjct: 261 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 320 Query: 221 --DPEPNYAGEPYVAIKAY--TAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGY 274 P P GE AI Y A E+SL +G+ V ++ ++ W+ I + G Sbjct: 321 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 380 Query: 275 FPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKR 318 FP Y++ ++ A+ P SS R HS+ +R Sbjct: 381 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR-IHSLSSNKPQR 423 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/152 (23%), Positives = 67/152 (44%), Gaps = 35/152 (23%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPASFLEPLD-----SPDE 218 N+ + E++L GD V ++++ + W+ ++ ++G P S++E + + D Sbjct: 340 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 399 Query: 219 TEDPEPNY--------------------------AGEPYVAIKAYTAVEGDEVSLLEGEA 252 + P P+ GEP+ A+ YT DE+ L E + Sbjct: 400 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 459 Query: 253 VEVIHKLLDGWWV--IRKDDVTGYFPSMYLQK 282 ++V+ K DGW+V R+ G FP Y+++ Sbjct: 460 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 491 Score = 34.3 bits (77), Expect = 0.20 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKR--GWIPASFLEPL 213 + ++A+ NY + E+ L DV++V+EK + GW+ + + G P ++++ L Sbjct: 436 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492 Score = 30.0 bits (66), Expect = 3.7 Identities = 14/53 (26%), Positives = 25/53 (47%) Query: 230 PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P A+ + A E+S +G+ V ++ K+ W+ G FP Y++K Sbjct: 259 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 311 >gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo sapiens] Length = 1004 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 8/164 (4%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE- 220 +A+ +++ + E++ GD V ++ K + W+ + + G P S++E L P++ + Sbjct: 773 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 832 Query: 221 --DPEPNYAGEPYVAIKAY--TAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGY 274 P P GE AI Y A E+SL +G+ V ++ ++ W+ I + G Sbjct: 833 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 892 Query: 275 FPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKR 318 FP Y++ ++ A+ P SS R HS+ +R Sbjct: 893 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR-IHSLSSNKPQR 935 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/152 (23%), Positives = 67/152 (44%), Gaps = 35/152 (23%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPASFLEPLD-----SPDE 218 N+ + E++L GD V ++++ + W+ ++ ++G P S++E + + D Sbjct: 852 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 911 Query: 219 TEDPEPNY--------------------------AGEPYVAIKAYTAVEGDEVSLLEGEA 252 + P P+ GEP+ A+ YT DE+ L E + Sbjct: 912 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 971 Query: 253 VEVIHKLLDGWWV--IRKDDVTGYFPSMYLQK 282 ++V+ K DGW+V R+ G FP Y+++ Sbjct: 972 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 1003 Score = 34.3 bits (77), Expect = 0.20 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKR--GWIPASFLEPL 213 + ++A+ NY + E+ L DV++V+EK + GW+ + + G P ++++ L Sbjct: 948 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004 Score = 30.0 bits (66), Expect = 3.7 Identities = 14/53 (26%), Positives = 25/53 (47%) Query: 230 PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P A+ + A E+S +G+ V ++ K+ W+ G FP Y++K Sbjct: 771 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 823 >gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo sapiens] Length = 824 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 8/164 (4%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE- 220 +A+ +++ + E++ GD V ++ K + W+ + + G P S++E L P++ + Sbjct: 593 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 652 Query: 221 --DPEPNYAGEPYVAIKAY--TAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGY 274 P P GE AI Y A E+SL +G+ V ++ ++ W+ I + G Sbjct: 653 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 712 Query: 275 FPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKR 318 FP Y++ ++ A+ P SS R HS+ +R Sbjct: 713 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR-IHSLSSNKPQR 755 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/152 (23%), Positives = 67/152 (44%), Gaps = 35/152 (23%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPASFLEPLD-----SPDE 218 N+ + E++L GD V ++++ + W+ ++ ++G P S++E + + D Sbjct: 672 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 731 Query: 219 TEDPEPNY--------------------------AGEPYVAIKAYTAVEGDEVSLLEGEA 252 + P P+ GEP+ A+ YT DE+ L E + Sbjct: 732 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 791 Query: 253 VEVIHKLLDGWWV--IRKDDVTGYFPSMYLQK 282 ++V+ K DGW+V R+ G FP Y+++ Sbjct: 792 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 823 Score = 34.3 bits (77), Expect = 0.20 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKR--GWIPASFLEPL 213 + ++A+ NY + E+ L DV++V+EK + GW+ + + G P ++++ L Sbjct: 768 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824 Score = 30.0 bits (66), Expect = 3.7 Identities = 14/53 (26%), Positives = 25/53 (47%) Query: 230 PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P A+ + A E+S +G+ V ++ K+ W+ G FP Y++K Sbjct: 591 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 643 >gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo sapiens] Length = 661 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 8/164 (4%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE- 220 +A+ +++ + E++ GD V ++ K + W+ + + G P S++E L P++ + Sbjct: 430 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 489 Query: 221 --DPEPNYAGEPYVAIKAY--TAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGY 274 P P GE AI Y A E+SL +G+ V ++ ++ W+ I + G Sbjct: 490 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 549 Query: 275 FPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKR 318 FP Y++ ++ A+ P SS R HS+ +R Sbjct: 550 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR-IHSLSSNKPQR 592 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/152 (23%), Positives = 67/152 (44%), Gaps = 35/152 (23%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPASFLEPLD-----SPDE 218 N+ + E++L GD V ++++ + W+ ++ ++G P S++E + + D Sbjct: 509 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 568 Query: 219 TEDPEPNY--------------------------AGEPYVAIKAYTAVEGDEVSLLEGEA 252 + P P+ GEP+ A+ YT DE+ L E + Sbjct: 569 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 628 Query: 253 VEVIHKLLDGWWV--IRKDDVTGYFPSMYLQK 282 ++V+ K DGW+V R+ G FP Y+++ Sbjct: 629 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 660 Score = 34.3 bits (77), Expect = 0.20 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKR--GWIPASFLEPL 213 + ++A+ NY + E+ L DV++V+EK + GW+ + + G P ++++ L Sbjct: 605 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661 Score = 30.0 bits (66), Expect = 3.7 Identities = 14/53 (26%), Positives = 25/53 (47%) Query: 230 PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P A+ + A E+S +G+ V ++ K+ W+ G FP Y++K Sbjct: 428 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 480 >gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo sapiens] Length = 731 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 8/164 (4%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE- 220 +A+ +++ + E++ GD V ++ K + W+ + + G P S++E L P++ + Sbjct: 500 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 559 Query: 221 --DPEPNYAGEPYVAIKAY--TAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGY 274 P P GE AI Y A E+SL +G+ V ++ ++ W+ I + G Sbjct: 560 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 619 Query: 275 FPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKR 318 FP Y++ ++ A+ P SS R HS+ +R Sbjct: 620 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR-IHSLSSNKPQR 662 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/152 (23%), Positives = 67/152 (44%), Gaps = 35/152 (23%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPASFLEPLD-----SPDE 218 N+ + E++L GD V ++++ + W+ ++ ++G P S++E + + D Sbjct: 579 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 638 Query: 219 TEDPEPNY--------------------------AGEPYVAIKAYTAVEGDEVSLLEGEA 252 + P P+ GEP+ A+ YT DE+ L E + Sbjct: 639 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 698 Query: 253 VEVIHKLLDGWWV--IRKDDVTGYFPSMYLQK 282 ++V+ K DGW+V R+ G FP Y+++ Sbjct: 699 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 730 Score = 34.3 bits (77), Expect = 0.20 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKR--GWIPASFLEPL 213 + ++A+ NY + E+ L DV++V+EK + GW+ + + G P ++++ L Sbjct: 675 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731 Score = 30.0 bits (66), Expect = 3.7 Identities = 14/53 (26%), Positives = 25/53 (47%) Query: 230 PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P A+ + A E+S +G+ V ++ K+ W+ G FP Y++K Sbjct: 498 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 550 >gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo sapiens] Length = 644 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 8/164 (4%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE- 220 +A+ +++ + E++ GD V ++ K + W+ + + G P S++E L P++ + Sbjct: 413 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 472 Query: 221 --DPEPNYAGEPYVAIKAY--TAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGY 274 P P GE AI Y A E+SL +G+ V ++ ++ W+ I + G Sbjct: 473 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 532 Query: 275 FPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKR 318 FP Y++ ++ A+ P SS R HS+ +R Sbjct: 533 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR-IHSLSSNKPQR 575 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/152 (23%), Positives = 67/152 (44%), Gaps = 35/152 (23%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPASFLEPLD-----SPDE 218 N+ + E++L GD V ++++ + W+ ++ ++G P S++E + + D Sbjct: 492 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 551 Query: 219 TEDPEPNY--------------------------AGEPYVAIKAYTAVEGDEVSLLEGEA 252 + P P+ GEP+ A+ YT DE+ L E + Sbjct: 552 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 611 Query: 253 VEVIHKLLDGWWV--IRKDDVTGYFPSMYLQK 282 ++V+ K DGW+V R+ G FP Y+++ Sbjct: 612 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 643 Score = 34.3 bits (77), Expect = 0.20 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKR--GWIPASFLEPL 213 + ++A+ NY + E+ L DV++V+EK + GW+ + + G P ++++ L Sbjct: 588 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644 Score = 30.0 bits (66), Expect = 3.7 Identities = 14/53 (26%), Positives = 25/53 (47%) Query: 230 PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P A+ + A E+S +G+ V ++ K+ W+ G FP Y++K Sbjct: 411 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 463 >gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo sapiens] Length = 1100 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 8/164 (4%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE- 220 +A+ +++ + E++ GD V ++ K + W+ + + G P S++E L P++ + Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 928 Query: 221 --DPEPNYAGEPYVAIKAY--TAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGY 274 P P GE AI Y A E+SL +G+ V ++ ++ W+ I + G Sbjct: 929 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 988 Query: 275 FPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKR 318 FP Y++ ++ A+ P SS R HS+ +R Sbjct: 989 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR-IHSLSSNKPQR 1031 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/152 (23%), Positives = 67/152 (44%), Gaps = 35/152 (23%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPASFLEPLD-----SPDE 218 N+ + E++L GD V ++++ + W+ ++ ++G P S++E + + D Sbjct: 948 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 1007 Query: 219 TEDPEPNY--------------------------AGEPYVAIKAYTAVEGDEVSLLEGEA 252 + P P+ GEP+ A+ YT DE+ L E + Sbjct: 1008 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 1067 Query: 253 VEVIHKLLDGWWV--IRKDDVTGYFPSMYLQK 282 ++V+ K DGW+V R+ G FP Y+++ Sbjct: 1068 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 1099 Score = 34.3 bits (77), Expect = 0.20 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKR--GWIPASFLEPL 213 + ++A+ NY + E+ L DV++V+EK + GW+ + + G P ++++ L Sbjct: 1044 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100 Score = 30.0 bits (66), Expect = 3.7 Identities = 14/53 (26%), Positives = 25/53 (47%) Query: 230 PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P A+ + A E+S +G+ V ++ K+ W+ G FP Y++K Sbjct: 867 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 919 >gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo sapiens] Length = 666 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 8/164 (4%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETE- 220 +A+ +++ + E++ GD V ++ K + W+ + + G P S++E L P++ + Sbjct: 435 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 494 Query: 221 --DPEPNYAGEPYVAIKAY--TAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGY 274 P P GE AI Y A E+SL +G+ V ++ ++ W+ I + G Sbjct: 495 ARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI 554 Query: 275 FPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKR 318 FP Y++ ++ A+ P SS R HS+ +R Sbjct: 555 FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR-IHSLSSNKPQR 597 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/152 (23%), Positives = 67/152 (44%), Gaps = 35/152 (23%) Query: 166 NYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPASFLEPLD-----SPDE 218 N+ + E++L GD V ++++ + W+ ++ ++G P S++E + + D Sbjct: 514 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 573 Query: 219 TEDPEPNY--------------------------AGEPYVAIKAYTAVEGDEVSLLEGEA 252 + P P+ GEP+ A+ YT DE+ L E + Sbjct: 574 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 633 Query: 253 VEVIHKLLDGWWV--IRKDDVTGYFPSMYLQK 282 ++V+ K DGW+V R+ G FP Y+++ Sbjct: 634 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 665 Score = 34.3 bits (77), Expect = 0.20 Identities = 15/57 (26%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 159 QTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKR--GWIPASFLEPL 213 + ++A+ NY + E+ L DV++V+EK + GW+ + + G P ++++ L Sbjct: 610 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666 Score = 30.0 bits (66), Expect = 3.7 Identities = 14/53 (26%), Positives = 25/53 (47%) Query: 230 PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK 282 P A+ + A E+S +G+ V ++ K+ W+ G FP Y++K Sbjct: 433 PAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEK 485 >gi|166064038 PAK-interacting exchange factor beta isoform a [Homo sapiens] Length = 646 Score = 50.4 bits (119), Expect = 3e-06 Identities = 19/69 (27%), Positives = 37/69 (53%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETED 221 RA N+++T+ E++ S GDV+ V E GWW + + GW P++++ + + ++ Sbjct: 12 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVS 71 Query: 222 PEPNYAGEP 230 P+ P Sbjct: 72 PKSGTLKSP 80 Score = 33.9 bits (76), Expect = 0.26 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 5/62 (8%) Query: 243 DEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK---SGQDVSQAQRQIKRGAP 299 DE+S +G+ + V GWW + TG+FPS Y+++ S + VS +K +P Sbjct: 23 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLK--SP 80 Query: 300 PR 301 P+ Sbjct: 81 PK 82 >gi|166064036 PAK-interacting exchange factor beta isoform d [Homo sapiens] Length = 753 Score = 50.4 bits (119), Expect = 3e-06 Identities = 19/69 (27%), Positives = 37/69 (53%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETED 221 RA N+++T+ E++ S GDV+ V E GWW + + GW P++++ + + ++ Sbjct: 140 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVS 199 Query: 222 PEPNYAGEP 230 P+ P Sbjct: 200 PKSGTLKSP 208 Score = 33.9 bits (76), Expect = 0.26 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 5/62 (8%) Query: 243 DEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK---SGQDVSQAQRQIKRGAP 299 DE+S +G+ + V GWW + TG+FPS Y+++ S + VS +K +P Sbjct: 151 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLK--SP 208 Query: 300 PR 301 P+ Sbjct: 209 PK 210 >gi|166064034 PAK-interacting exchange factor beta isoform c [Homo sapiens] Length = 803 Score = 50.4 bits (119), Expect = 3e-06 Identities = 19/69 (27%), Positives = 37/69 (53%) Query: 162 RAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETED 221 RA N+++T+ E++ S GDV+ V E GWW + + GW P++++ + + ++ Sbjct: 190 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVS 249 Query: 222 PEPNYAGEP 230 P+ P Sbjct: 250 PKSGTLKSP 258 Score = 33.9 bits (76), Expect = 0.26 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 5/62 (8%) Query: 243 DEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK---SGQDVSQAQRQIKRGAP 299 DE+S +G+ + V GWW + TG+FPS Y+++ S + VS +K +P Sbjct: 201 DELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLK--SP 258 Query: 300 PR 301 P+ Sbjct: 259 PK 260 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.133 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,372,023 Number of Sequences: 37866 Number of extensions: 810629 Number of successful extensions: 5245 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 161 Number of HSP's successfully gapped in prelim test: 163 Number of HSP's that attempted gapping in prelim test: 4438 Number of HSP's gapped (non-prelim): 837 length of query: 390 length of database: 18,247,518 effective HSP length: 104 effective length of query: 286 effective length of database: 14,309,454 effective search space: 4092503844 effective search space used: 4092503844 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.