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Search of human proteins with 171906575
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|171906575 drebrin-like isoform c [Homo sapiens]
(439 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|171906575 drebrin-like isoform c [Homo sapiens] 891 0.0
gi|21361670 drebrin-like isoform a [Homo sapiens] 868 0.0
gi|62198235 drebrin-like isoform b [Homo sapiens] 862 0.0
gi|18426915 drebrin 1 isoform a [Homo sapiens] 219 3e-57
gi|18426913 drebrin 1 isoform b [Homo sapiens] 203 3e-52
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 102 5e-22
gi|20357552 cortactin isoform a [Homo sapiens] 99 8e-21
gi|20357556 cortactin isoform b [Homo sapiens] 99 8e-21
gi|5453710 LIM and SH3 protein 1 [Homo sapiens] 62 8e-10
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 62 1e-09
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 62 1e-09
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 62 1e-09
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 57 3e-08
gi|115527120 nebulin [Homo sapiens] 56 6e-08
gi|47087157 nebulette non-muscle isoform [Homo sapiens] 55 1e-07
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 55 1e-07
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 55 1e-07
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 54 4e-07
gi|154354979 myosin X [Homo sapiens] 53 5e-07
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 53 5e-07
gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 53 6e-07
gi|148747351 protein kinase C and casein kinase substrate in neu... 53 6e-07
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 52 8e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 52 8e-07
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 52 1e-06
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 52 1e-06
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 52 1e-06
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 52 1e-06
gi|239756174 PREDICTED: hypothetical protein [Homo sapiens] 51 2e-06
gi|239750672 PREDICTED: hypothetical protein [Homo sapiens] 51 2e-06
>gi|171906575 drebrin-like isoform c [Homo sapiens]
Length = 439
Score = 891 bits (2302), Expect = 0.0
Identities = 439/439 (100%), Positives = 439/439 (100%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
Query: 241 QQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 300
QQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT
Sbjct: 241 QQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 300
Query: 301 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 360
QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ
Sbjct: 301 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 360
Query: 361 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 420
QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG
Sbjct: 361 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 420
Query: 421 YGPDGHFGMFPANYVELIE 439
YGPDGHFGMFPANYVELIE
Sbjct: 421 YGPDGHFGMFPANYVELIE 439
>gi|21361670 drebrin-like isoform a [Homo sapiens]
Length = 431
Score = 868 bits (2242), Expect = 0.0
Identities = 431/439 (98%), Positives = 431/439 (98%), Gaps = 8/439 (1%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
Query: 241 QQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 300
QQEVVSRNRNE QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT
Sbjct: 241 QQEVVSRNRNE--------QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 292
Query: 301 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 360
QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ
Sbjct: 293 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 352
Query: 361 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 420
QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG
Sbjct: 353 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 412
Query: 421 YGPDGHFGMFPANYVELIE 439
YGPDGHFGMFPANYVELIE
Sbjct: 413 YGPDGHFGMFPANYVELIE 431
>gi|62198235 drebrin-like isoform b [Homo sapiens]
Length = 430
Score = 862 bits (2226), Expect = 0.0
Identities = 430/439 (97%), Positives = 430/439 (97%), Gaps = 9/439 (2%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ RTWEQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ-RTWEQ 239
Query: 241 QQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 300
QQEVVSRNRNE QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT
Sbjct: 240 QQEVVSRNRNE--------QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 291
Query: 301 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 360
QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ
Sbjct: 292 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 351
Query: 361 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 420
QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG
Sbjct: 352 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 411
Query: 421 YGPDGHFGMFPANYVELIE 439
YGPDGHFGMFPANYVELIE
Sbjct: 412 YGPDGHFGMFPANYVELIE 430
>gi|18426915 drebrin 1 isoform a [Homo sapiens]
Length = 649
Score = 219 bits (559), Expect = 3e-57
Identities = 132/372 (35%), Positives = 204/372 (54%), Gaps = 35/372 (9%)
Query: 3 ANLSRNGPALQ--EAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
A +S +G L+ AY V+ E+S DWAL+TYE S+D+++A +GEGGL+E+ +
Sbjct: 2 AGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQ 61
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMY FC VKD + LPK+VLINW GE V D RK ACASHV+ +A F +G V +NA +
Sbjct: 62 KVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSV 121
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
ED++ I ++++ S R ++ PVG+ YQKT+A E+KR+ ++ FW
Sbjct: 122 EDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFW 181
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE- 239
+A+KEEE R+ EE+++A + + + EQER E+E +E RE+RY+E+ + R +
Sbjct: 182 EQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQT 241
Query: 240 ----------QQQEVVSRNRNEQGSTCASLQESAV------------HPREIFKQKERAM 277
++Q + +R+E+ T ES V +PRE FKQ+ER
Sbjct: 242 LEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVA 301
Query: 278 STTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPC--LV 335
S ++ S P SPF + + ++H P +R P++ STP +
Sbjct: 302 SASAGSCDVP----SPFNHRPGSHLDSHRRMAPTPIPTRS----PSDSSTASTPVAEQIE 353
Query: 336 QAEEEAVYEEPP 347
+A +E +PP
Sbjct: 354 RALDEVTSSQPP 365
>gi|18426913 drebrin 1 isoform b [Homo sapiens]
Length = 651
Score = 203 bits (516), Expect = 3e-52
Identities = 121/344 (35%), Positives = 188/344 (54%), Gaps = 33/344 (9%)
Query: 29 ALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEG 88
AL+TYE S+D+++A +GEGGL+E+ + KVMY FC VKD + LPK+VLINW GE
Sbjct: 32 ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED 91
Query: 89 VNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGR 148
V D RK ACASHV+ +A F +G V +NA + ED++ I ++++ S R
Sbjct: 92 VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR 151
Query: 149 FQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE 208
++ PVG+ YQKT+A E+KR+ ++ FW +A+KEEE R+ EE+++A + + + EQE
Sbjct: 152 LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE 211
Query: 209 RRERELREAARREQRYQEQGGEASPQSRTWE-----------QQQEVVSRNRNEQGSTCA 257
R E+E +E RE+RY+E+ + R + ++Q + +R+E+ T
Sbjct: 212 RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM 271
Query: 258 SLQESAV------------HPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 305
ES V +PRE FKQ+ER S ++ S P SPF + + ++H
Sbjct: 272 KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVP----SPFNHRPGSHLDSH 327
Query: 306 FGREPAAAISRPRADLPAEEPAPSTPPC--LVQAEEEAVYEEPP 347
P +R P++ STP + +A +E +PP
Sbjct: 328 RRMAPTPIPTRS----PSDSSTASTPVAEQIERALDEVTSSQPP 367
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 102 bits (255), Expect = 5e-22
Identities = 105/350 (30%), Positives = 144/350 (41%), Gaps = 97/350 (27%)
Query: 133 AKASGANYSFHKESGRFQDVG---PQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEEN 189
AK G Y K+ VG +AP + Y+KT + E G AK E
Sbjct: 191 AKGFGGQYGIQKDRVDKSAVGFNEMEAPT-TAYKKTTPI-EAASSGTRGLKAKFES---- 244
Query: 190 RRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNR 249
EEKR+ EE ++ + RR++E + +R SP E Q V++
Sbjct: 245 -MAEEKRKREEEEKAQQVARRQQERKAVTKR-----------SP-----EAPQPVIAM-- 285
Query: 250 NEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRS----PFLQKQLTQPETH 305
E+ + A L P++I + + T S +P + P L + T PE +
Sbjct: 286 -EEPAVPAPL------PKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDN 338
Query: 306 FGREPAAAISRPRADLPAEEPAPSTPPCLV---QAEEEAVYEEPPEQETFYEQPPLVQQQ 362
EEP P+ PP + Q EEE VYE PE E E P +
Sbjct: 339 ------------------EEP-PALPPRTLEGLQVEEEPVYEAEPEPEP--EPEPEPEND 377
Query: 363 GAGSEHIDHHIQ---------------------------------GQGLSGQGLCARALY 389
E +D H Q G G G+ A ALY
Sbjct: 378 YEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALY 437
Query: 390 DYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE 439
DYQ E+SFDP+++IT IE++DEGWWRG GHFG+FPANYV+L+E
Sbjct: 438 DYQGEGSDELSFDPDDVITDIEMVDEGWWRG-RCHGHFGLFPANYVKLLE 486
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 99.0 bits (245), Expect = 8e-21
Identities = 94/312 (30%), Positives = 127/312 (40%), Gaps = 73/312 (23%)
Query: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEE 187
+K G Y K+ + F+DV V S YQKT V + +K
Sbjct: 303 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVT--------SKTSNIR 351
Query: 188 ENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSR 247
N K + +E +R+ E ER +R +E Q+QE R
Sbjct: 352 ANFENLAKEKEQEDRRKAEAERAQRMAKE----------------------RQEQEEARR 389
Query: 248 NRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFG 307
EQ A Q V P +PQP + R P + P
Sbjct: 390 KLEEQAR--AKTQTPPVSP-----------------APQPTEERLP------SSPVY--- 421
Query: 308 REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSE 367
E AA+ +A+L P T P V + E A Y E Q+ V +
Sbjct: 422 -EDAASF---KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPG 477
Query: 368 HI--DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDG 425
H + + + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG G
Sbjct: 478 HYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKG 536
Query: 426 HFGMFPANYVEL 437
+G+FPANYVEL
Sbjct: 537 RYGLFPANYVEL 548
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 99.0 bits (245), Expect = 8e-21
Identities = 94/312 (30%), Positives = 127/312 (40%), Gaps = 73/312 (23%)
Query: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEE 187
+K G Y K+ + F+DV V S YQKT V + +K
Sbjct: 266 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVT--------SKTSNIR 314
Query: 188 ENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSR 247
N K + +E +R+ E ER +R +E Q+QE R
Sbjct: 315 ANFENLAKEKEQEDRRKAEAERAQRMAKE----------------------RQEQEEARR 352
Query: 248 NRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFG 307
EQ A Q V P +PQP + R P + P
Sbjct: 353 KLEEQAR--AKTQTPPVSP-----------------APQPTEERLP------SSPVY--- 384
Query: 308 REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSE 367
E AA+ +A+L P T P V + E A Y E Q+ V +
Sbjct: 385 -EDAASF---KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPG 440
Query: 368 HI--DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDG 425
H + + + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG G
Sbjct: 441 HYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKG 499
Query: 426 HFGMFPANYVEL 437
+G+FPANYVEL
Sbjct: 500 RYGLFPANYVEL 511
>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
Length = 261
Score = 62.4 bits (150), Expect = 8e-10
Identities = 49/147 (33%), Positives = 64/147 (43%), Gaps = 16/147 (10%)
Query: 296 QKQLTQPETHFGREPAAAISRPRADL--PAEEPAPSTPPCLVQAEEEAVYEEPPEQETFY 353
+K P G EP S+ + P E+ P P VY++P +Q
Sbjct: 127 EKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPT-----SAPVYQQPQQQ---- 177
Query: 354 EQPPLVQQQGAGSEHIDH-HIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEV 412
P+ Q G E IQ G G RA+YDY AAD+ E+SF + I ++
Sbjct: 178 ---PVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQ 234
Query: 413 IDEGWWRG-YGPDGHFGMFPANYVELI 438
ID+GW G G GM PANYVE I
Sbjct: 235 IDDGWMYGTVERTGDTGMLPANYVEAI 261
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 62.0 bits (149), Expect = 1e-09
Identities = 63/278 (22%), Positives = 111/278 (39%), Gaps = 36/278 (12%)
Query: 175 GKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ 234
GK++ W +EN R EE EE Q++L++E+ + +++E R+ + Q + +
Sbjct: 672 GKENLW------KENLRKEE----EEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 721
Query: 235 SRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF 294
+ V+ R + E + + +I + E+ + +PG L F
Sbjct: 722 EEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVG-------EPGWLYGSF 774
Query: 295 ----------LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEE 340
+++ E P A+ P L A EP S P V +
Sbjct: 775 QGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQN 834
Query: 341 AVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEIS 400
+ ++ ++ + GS H GQG + L A+AL + A D ++
Sbjct: 835 VSFSNLTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLN 891
Query: 401 FDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 438
F ++IT +E E WW G G G FP +YV++I
Sbjct: 892 FSKHDIITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 927
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 387 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 437
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1156
Score = 38.1 bits (87), Expect = 0.016
Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 1/83 (1%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERR-ERELREAARREQRYQEQGGEASPQSRTWEQ 240
KA E N LE++R+A Q+Q E ER+ ++E E R+++ QEQ + + +
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 241 QQEVVSRNRNEQGSTCASLQESA 263
+Q + R R E+ +E+A
Sbjct: 428 KQRELERQREEERRKDIERREAA 450
Score = 35.8 bits (81), Expect = 0.079
Identities = 29/121 (23%), Positives = 60/121 (49%), Gaps = 11/121 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+++E ++LE ++R E+ QR+LE++R E ++ RRE QE + + +Q+
Sbjct: 412 QEQEWKKQLELEKRLEK-QRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
Query: 244 VVSRNRNEQGSTCASLQESAVH-PREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQP 302
+ +NR ++ + ++ +H E K + +S G+L+ L+KQ +
Sbjct: 471 LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS---------GRLQDVRLKKQTQKT 521
Query: 303 E 303
E
Sbjct: 522 E 522
Score = 35.0 bits (79), Expect = 0.14
Identities = 24/99 (24%), Positives = 49/99 (49%), Gaps = 12/99 (12%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQS 235
+ K ++EE ++L E+KR+A + +E E+R + L E +RE + Q +
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQ-----KEK 401
Query: 236 RTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKE 274
WE++Q + + ++ L++ RE+ +Q+E
Sbjct: 402 EEWERKQREL---QEQEWKKQLELEKRLEKQRELERQRE 437
Score = 33.1 bits (74), Expect = 0.51
Identities = 24/114 (21%), Positives = 54/114 (47%), Gaps = 8/114 (7%)
Query: 162 YQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARRE 221
Y++ N E +R + + ++E E + +EK E QR+L+++ +++L E +R
Sbjct: 371 YERGNMELEKRR---QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL-ELEKRL 426
Query: 222 QRYQEQGGEASPQSRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKER 275
++ +E + + R +++E + Q L+ + +E+ QK R
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQ----RRLEWERIRRQELLNQKNR 476
Score = 32.3 bits (72), Expect = 0.88
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 391 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 438
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1088
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 62.0 bits (149), Expect = 1e-09
Identities = 63/278 (22%), Positives = 111/278 (39%), Gaps = 36/278 (12%)
Query: 175 GKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ 234
GK++ W +EN R EE EE Q++L++E+ + +++E R+ + Q + +
Sbjct: 699 GKENLW------KENLRKEE----EEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 748
Query: 235 SRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF 294
+ V+ R + E + + +I + E+ + +PG L F
Sbjct: 749 EEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVG-------EPGWLYGSF 801
Query: 295 ----------LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEE 340
+++ E P A+ P L A EP S P V +
Sbjct: 802 QGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQN 861
Query: 341 AVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEIS 400
+ ++ ++ + GS H GQG + L A+AL + A D ++
Sbjct: 862 VSFSNLTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLN 918
Query: 401 FDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 438
F ++IT +E E WW G G G FP +YV++I
Sbjct: 919 FSKHDIITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 954
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 387 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 437
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1183
Score = 38.1 bits (87), Expect = 0.016
Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 1/83 (1%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERR-ERELREAARREQRYQEQGGEASPQSRTWEQ 240
KA E N LE++R+A Q+Q E ER+ ++E E R+++ QEQ + + +
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 241 QQEVVSRNRNEQGSTCASLQESA 263
+Q + R R E+ +E+A
Sbjct: 428 KQRELERQREEERRKDIERREAA 450
Score = 35.8 bits (81), Expect = 0.079
Identities = 29/121 (23%), Positives = 60/121 (49%), Gaps = 11/121 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+++E ++LE ++R E+ QR+LE++R E ++ RRE QE + + +Q+
Sbjct: 412 QEQEWKKQLELEKRLEK-QRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
Query: 244 VVSRNRNEQGSTCASLQESAVH-PREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQP 302
+ +NR ++ + ++ +H E K + +S G+L+ L+KQ +
Sbjct: 471 LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS---------GRLQDVRLKKQTQKT 521
Query: 303 E 303
E
Sbjct: 522 E 522
Score = 35.0 bits (79), Expect = 0.14
Identities = 24/99 (24%), Positives = 49/99 (49%), Gaps = 12/99 (12%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQS 235
+ K ++EE ++L E+KR+A + +E E+R + L E +RE + Q +
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQ-----KEK 401
Query: 236 RTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKE 274
WE++Q + + ++ L++ RE+ +Q+E
Sbjct: 402 EEWERKQREL---QEQEWKKQLELEKRLEKQRELERQRE 437
Score = 33.1 bits (74), Expect = 0.51
Identities = 24/114 (21%), Positives = 54/114 (47%), Gaps = 8/114 (7%)
Query: 162 YQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARRE 221
Y++ N E +R + + ++E E + +EK E QR+L+++ +++L E +R
Sbjct: 371 YERGNMELEKRR---QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL-ELEKRL 426
Query: 222 QRYQEQGGEASPQSRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKER 275
++ +E + + R +++E + Q L+ + +E+ QK R
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQ----RRLEWERIRRQELLNQKNR 476
Score = 32.3 bits (72), Expect = 0.88
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 391 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 438
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 62.0 bits (149), Expect = 1e-09
Identities = 63/278 (22%), Positives = 111/278 (39%), Gaps = 36/278 (12%)
Query: 175 GKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ 234
GK++ W +EN R EE EE Q++L++E+ + +++E R+ + Q + +
Sbjct: 699 GKENLW------KENLRKEE----EEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 748
Query: 235 SRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF 294
+ V+ R + E + + +I + E+ + +PG L F
Sbjct: 749 EEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVG-------EPGWLYGSF 801
Query: 295 ----------LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEE 340
+++ E P A+ P L A EP S P V +
Sbjct: 802 QGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQN 861
Query: 341 AVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEIS 400
+ ++ ++ + GS H GQG + L A+AL + A D ++
Sbjct: 862 VSFSNLTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLN 918
Query: 401 FDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 438
F ++IT +E E WW G G G FP +YV++I
Sbjct: 919 FSKHDIITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 954
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 387 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 437
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1183
Score = 38.1 bits (87), Expect = 0.016
Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 1/83 (1%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERR-ERELREAARREQRYQEQGGEASPQSRTWEQ 240
KA E N LE++R+A Q+Q E ER+ ++E E R+++ QEQ + + +
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 241 QQEVVSRNRNEQGSTCASLQESA 263
+Q + R R E+ +E+A
Sbjct: 428 KQRELERQREEERRKDIERREAA 450
Score = 35.8 bits (81), Expect = 0.079
Identities = 29/121 (23%), Positives = 60/121 (49%), Gaps = 11/121 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+++E ++LE ++R E+ QR+LE++R E ++ RRE QE + + +Q+
Sbjct: 412 QEQEWKKQLELEKRLEK-QRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
Query: 244 VVSRNRNEQGSTCASLQESAVH-PREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQP 302
+ +NR ++ + ++ +H E K + +S G+L+ L+KQ +
Sbjct: 471 LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS---------GRLQDVRLKKQTQKT 521
Query: 303 E 303
E
Sbjct: 522 E 522
Score = 35.0 bits (79), Expect = 0.14
Identities = 24/99 (24%), Positives = 49/99 (49%), Gaps = 12/99 (12%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQS 235
+ K ++EE ++L E+KR+A + +E E+R + L E +RE + Q +
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQ-----KEK 401
Query: 236 RTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKE 274
WE++Q + + ++ L++ RE+ +Q+E
Sbjct: 402 EEWERKQREL---QEQEWKKQLELEKRLEKQRELERQRE 437
Score = 33.1 bits (74), Expect = 0.51
Identities = 24/114 (21%), Positives = 54/114 (47%), Gaps = 8/114 (7%)
Query: 162 YQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARRE 221
Y++ N E +R + + ++E E + +EK E QR+L+++ +++L E +R
Sbjct: 371 YERGNMELEKRR---QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL-ELEKRL 426
Query: 222 QRYQEQGGEASPQSRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKER 275
++ +E + + R +++E + Q L+ + +E+ QK R
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQ----RRLEWERIRRQELLNQKNR 476
Score = 32.3 bits (72), Expect = 0.88
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 391 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 438
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 57.4 bits (137), Expect = 3e-08
Identities = 46/147 (31%), Positives = 76/147 (51%), Gaps = 10/147 (6%)
Query: 181 AKAEKEEENRRLEEKRRAEEAQ-RQLEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
A+AE+E E RR EE+ E+AQ Q EQER +++ EA R + E+ + + + ++
Sbjct: 642 ARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAER--QRLEREKHFQ 699
Query: 240 QQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGK---LRSPFLQ 296
QQ++ R ++S V E ++++ + + SSP+P K RSP LQ
Sbjct: 700 QQEQERQERRKRLEEIMKRTRKSEV--SETKQKQDSKEANANGSSPEPVKAVEARSPGLQ 757
Query: 297 KQLTQPETHFGREPAAAISRPRADLPA 323
K+ Q E +EP ++ P +LPA
Sbjct: 758 KEAVQKEEPIPQEPQWSL--PSKELPA 782
Score = 34.7 bits (78), Expect = 0.18
Identities = 44/168 (26%), Positives = 73/168 (43%), Gaps = 29/168 (17%)
Query: 176 KDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQ-----EQGGE 230
K + W EKEE+ + L EK + +E +R+LE++R + E R AA E++ Q ++ E
Sbjct: 156 KKAVWL--EKEEKAKALREK-QLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYE 212
Query: 231 ASPQ---SRTWEQQQEV----------VSRNRNEQGSTCA-SLQESAVHPREIFKQKERA 276
A+ Q +TW + ++ S GS C+ S H I ++
Sbjct: 213 AAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSK 272
Query: 277 MSTTSISSP------QPGKLRSPFLQKQLTQPETHFGREPAAAISRPR 318
S T +SP Q S + + +T P F +A++ PR
Sbjct: 273 SSATLWNSPSRNRSLQLSAWESSIVDRLMT-PTLSFLARSRSAVTLPR 319
Score = 33.1 bits (74), Expect = 0.51
Identities = 22/82 (26%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 170 EIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARR--EQRYQEQ 227
E+K+ G+ AK +EE + L K+ + + + RE++L+E RR EQR + +
Sbjct: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190
Query: 228 GGEASPQSRTWEQQQEVVSRNR 249
A+ + E+Q++ + +N+
Sbjct: 191 QRRAALE----ERQRQKLEKNK 208
Score = 31.2 bits (69), Expect = 1.9
Identities = 27/110 (24%), Positives = 40/110 (36%), Gaps = 6/110 (5%)
Query: 232 SPQSRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLR 291
SP+ T + V + ++ + A ++ + R +KE A + SP P
Sbjct: 496 SPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTP 555
Query: 292 SPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEA 341
+P Q QP + A S P PA PS P EEA
Sbjct: 556 AP---PQKEQPPAETPTDAAVLTSPP---APAPPVTPSKPMAGTTDREEA 599
>gi|115527120 nebulin [Homo sapiens]
Length = 6669
Score = 56.2 bits (134), Expect = 6e-08
Identities = 30/61 (49%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 379 SGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG-YGPDGHFGMFPANYVEL 437
S G RA+YDY AAD E+SF + I ++ IDEGW G G GM PANYVE
Sbjct: 6609 STAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDEGWMYGTVQRTGRTGMLPANYVEA 6668
Query: 438 I 438
I
Sbjct: 6669 I 6669
>gi|47087157 nebulette non-muscle isoform [Homo sapiens]
Length = 270
Score = 55.5 bits (132), Expect = 1e-07
Identities = 49/198 (24%), Positives = 80/198 (40%), Gaps = 22/198 (11%)
Query: 257 ASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAIS- 315
+ LQ + R+ + K R S + +P+ +L+ Q+Q++ + H E
Sbjct: 78 SELQSQVKYKRDFEESKGRGFSIVT-DTPELQRLKRT--QEQISNVKYHEDFEKTKGRGF 134
Query: 316 RPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQG 375
P D P E + A + V+ E + +P ++ + H QG
Sbjct: 135 TPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMD---RRPGIIVAPVLPGAYQQSHSQG 191
Query: 376 QGLSGQGLCA--------------RALYDYQAADDTEISFDPENLITGIEVIDEGWWRG- 420
G Q + RA+YDY A D+ E+SF + I ++ ID+GW G
Sbjct: 192 YGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGT 251
Query: 421 YGPDGHFGMFPANYVELI 438
G GM PANY+E +
Sbjct: 252 VQRTGRTGMLPANYIEFV 269
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 55.1 bits (131), Expect = 1e-07
Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 184 EKEEENRRLEEKRRAE-EAQRQLEQERRERELREAAR-----REQRYQEQGGEASPQSRT 237
+++E+ RRLEE++R E EA+RQ E+E+R RE E R R ++ +E+ A + R
Sbjct: 401 QQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 238 WEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQK 297
E++QE + R E+ LQ+ + + + R P P +
Sbjct: 461 VEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSF 520
Query: 298 QLTQPETHFGREPA 311
+P+ H+ EPA
Sbjct: 521 HAPEPKAHY--EPA 532
Score = 30.0 bits (66), Expect = 4.3
Identities = 41/177 (23%), Positives = 69/177 (38%), Gaps = 23/177 (12%)
Query: 193 EEKRRAEEAQRQL---EQERRERE---LREAARREQRYQEQGGEASPQSRTWEQQQ--EV 244
E K R+E +RQ EQ+ RE+E + A R++R ++Q Q R E+QQ E
Sbjct: 362 ENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQ----KEQRRRLEEQQRRER 417
Query: 245 VSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPET 304
+R + E+ +E ++KE + + + ++++QL + +
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Query: 305 HFG-------REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYE 354
H +E A + R P P P Q E PE + YE
Sbjct: 478 HLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPP----QQERSKPSFHAPEPKAHYE 530
Score = 29.3 bits (64), Expect = 7.4
Identities = 42/160 (26%), Positives = 62/160 (38%), Gaps = 27/160 (16%)
Query: 204 QLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNR----NEQGSTCASL 259
+L+QE +ER EA RR+Q QEQ Q R E+ + + R +Q L
Sbjct: 358 RLQQENKERS--EALRRQQLLQEQ------QLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 260 QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRA 319
+E RE +Q+ER Q K R L+++ + E R RA
Sbjct: 410 EEQQRREREARRQQEREQRRRE----QEEKRRLEELERRRKEEE-----------ERRRA 454
Query: 320 DLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLV 359
+ Q EEE + E +Q+ EQ L+
Sbjct: 455 EEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLL 494
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 55.1 bits (131), Expect = 1e-07
Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 184 EKEEENRRLEEKRRAE-EAQRQLEQERRERELREAAR-----REQRYQEQGGEASPQSRT 237
+++E+ RRLEE++R E EA+RQ E+E+R RE E R R ++ +E+ A + R
Sbjct: 401 QQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 238 WEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQK 297
E++QE + R E+ LQ+ + + + R P P +
Sbjct: 461 VEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSF 520
Query: 298 QLTQPETHFGREPA 311
+P+ H+ EPA
Sbjct: 521 HAPEPKAHY--EPA 532
Score = 38.9 bits (89), Expect = 0.009
Identities = 35/116 (30%), Positives = 49/116 (42%), Gaps = 9/116 (7%)
Query: 182 KAEKEEENRRLEEKRRAEEAQ----RQLEQERRERELREAARREQRYQEQGGEASPQSRT 237
+ E+EE R EEKRR E Q RQLE+E+R E+ + +Q QEQ R
Sbjct: 445 RKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ----QQLLQEQAMLLHDHRRP 500
Query: 238 WEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSP 293
Q + + E+ E H + +E + TTS SP + SP
Sbjct: 501 HPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTS-RSPVLSRRDSP 555
Score = 30.0 bits (66), Expect = 4.3
Identities = 41/177 (23%), Positives = 69/177 (38%), Gaps = 23/177 (12%)
Query: 193 EEKRRAEEAQRQL---EQERRERE---LREAARREQRYQEQGGEASPQSRTWEQQQ--EV 244
E K R+E +RQ EQ+ RE+E + A R++R ++Q Q R E+QQ E
Sbjct: 362 ENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQ----KEQRRRLEEQQRRER 417
Query: 245 VSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPET 304
+R + E+ +E ++KE + + + ++++QL + +
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Query: 305 HFG-------REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYE 354
H +E A + R P P P Q E PE + YE
Sbjct: 478 HLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPP----QQERSKPSFHAPEPKAHYE 530
Score = 29.3 bits (64), Expect = 7.4
Identities = 42/160 (26%), Positives = 62/160 (38%), Gaps = 27/160 (16%)
Query: 204 QLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNR----NEQGSTCASL 259
+L+QE +ER EA RR+Q QEQ Q R E+ + + R +Q L
Sbjct: 358 RLQQENKERS--EALRRQQLLQEQ------QLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 260 QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRA 319
+E RE +Q+ER Q K R L+++ + E R RA
Sbjct: 410 EEQQRREREARRQQEREQRRRE----QEEKRRLEELERRRKEEE-----------ERRRA 454
Query: 320 DLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLV 359
+ Q EEE + E +Q+ EQ L+
Sbjct: 455 EEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLL 494
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 53.5 bits (127), Expect = 4e-07
Identities = 57/227 (25%), Positives = 97/227 (42%), Gaps = 31/227 (13%)
Query: 119 AEEDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDS 178
AE+D E + + K G KE + GP Q+ A++++K ++
Sbjct: 305 AEDDNEGDKKKKDKKKKKGEKEEKEKEKKK----GPSKATVKAMQE--ALAKLK---EEE 355
Query: 179 FWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTW 238
K E+EE +RLEE + + +LEQE+RER+ ++ R++R +++G + R
Sbjct: 356 ERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREA 415
Query: 239 EQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQ 298
+ E + QG S ++S R I++ K+R + +Q
Sbjct: 416 RARAEATLKLLQAQGVEVPS-KDSLPKKRPIYEDKKRKK-----------------IPQQ 457
Query: 299 LTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE 345
L E E AA+ +P +E P PP V+ EEE E+
Sbjct: 458 LESKEVSESMELCAAVEVMEQGVPEKEETP--PP--VEPEEEEDTED 500
Score = 30.0 bits (66), Expect = 4.3
Identities = 18/76 (23%), Positives = 34/76 (44%), Gaps = 3/76 (3%)
Query: 180 WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
W +EE ++E + E + E+E E E E + +E+ GE+ + +
Sbjct: 506 WEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGES--EGSEGD 563
Query: 240 QQQEVVSRNRNEQGST 255
++ E VS + + G T
Sbjct: 564 EEDEKVS-DEKDSGKT 578
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 53.1 bits (126), Expect = 5e-07
Identities = 35/127 (27%), Positives = 64/127 (50%), Gaps = 1/127 (0%)
Query: 161 VYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEE-KRRAEEAQRQLEQERRERELREAAR 219
V+QK +RV + K E+EE+ ++ EE K++ EE +R+ E+ERRE ELR
Sbjct: 794 VFQKQLRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQE 853
Query: 220 REQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMST 279
E R Q++ + E +E+ + N+Q L++ + + +Q+E +++
Sbjct: 854 EETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTE 913
Query: 280 TSISSPQ 286
S+ Q
Sbjct: 914 ASLQKLQ 920
Score = 38.9 bits (89), Expect = 0.009
Identities = 25/94 (26%), Positives = 44/94 (46%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K ++EEE R E +RR E + Q E+E R+++ EA ++ Q+ E E Q + +
Sbjct: 829 KKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVE 888
Query: 242 QEVVSRNRNEQGSTCASLQESAVHPREIFKQKER 275
+ + E QE ++ + K +ER
Sbjct: 889 EILRLEKEIEDLQRMKEQQELSLTEASLQKLQER 922
Score = 30.0 bits (66), Expect = 4.3
Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 20/96 (20%)
Query: 182 KAEKEEENRR------LEEKRRAEEAQRQLEQE----------RRERELREAARREQRYQ 225
+A++EEE R+ L++ ++ E R+LE++ R E+E+ + R +++ +
Sbjct: 849 RAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQE 908
Query: 226 EQGGEASPQSRTWEQQQEVVSRNRNEQGSTCASLQE 261
EAS Q + QE+ R + C + QE
Sbjct: 909 LSLTEASLQKLQERRDQEL----RRLEEEACRAAQE 940
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 53.1 bits (126), Expect = 5e-07
Identities = 24/55 (43%), Positives = 34/55 (61%), Gaps = 1/55 (1%)
Query: 384 CARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 438
C RALYD++ ++ E+ F ++IT IDE W+ G GH G FP NYVE++
Sbjct: 294 CCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGM-LHGHSGFFPINYVEIL 347
>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
Length = 1014
Score = 52.8 bits (125), Expect = 6e-07
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 386 RALYDYQAADDTEISFDPENLITGIEVIDEGWWRG-YGPDGHFGMFPANYVELI 438
RA+YDY A D+ E+SF + I ++ ID+GW G G GM PANY+E +
Sbjct: 960 RAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 52.8 bits (125), Expect = 6e-07
Identities = 27/62 (43%), Positives = 39/62 (62%), Gaps = 1/62 (1%)
Query: 379 SGQGLCARALYDYQAADDTEISFDPENLITGIEVIDE-GWWRGYGPDGHFGMFPANYVEL 437
SG + RALYDY+ + E+SF + +T +E DE GW +G +G G++PANYVE
Sbjct: 425 SGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEA 484
Query: 438 IE 439
I+
Sbjct: 485 IQ 486
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 52.4 bits (124), Expect = 8e-07
Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 10/144 (6%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+KEEE RL + A+ Q EQERRE+E RE RREQ +EQ EQ+++
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ--------ERREQERQ 718
Query: 244 VVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPE 303
+ + R + + +E + + QKE+ + + + + ++QL + +
Sbjct: 719 LAEQERRREQERLQAERELQEREKALRLQKEQLQ--RELEEKKKKEEQQRLAERQLQEEQ 776
Query: 304 THFGREPAAAISRPRADLPAEEPA 327
+E A A + + PA
Sbjct: 777 EKKAKEAAGASKALNVTVDVQSPA 800
Score = 37.7 bits (86), Expect = 0.021
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 1/95 (1%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K EK +E R EEK + + A +++E+ R+ E ARR + Q++ E Q +++
Sbjct: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 668
Query: 242 QEVVSRNRN-EQGSTCASLQESAVHPREIFKQKER 275
+E R R + A +E +E +Q+ R
Sbjct: 669 EEEQERLRKAAEAKRLAEQREQERREQERREQERR 703
Score = 37.4 bits (85), Expect = 0.027
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 13/103 (12%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAE----EAQRQL-EQERR------- 210
++ +E KR+ + + E+E + E+ R E E +RQL EQERR
Sbjct: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
Query: 211 -ERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQ 252
EREL+E + + +EQ + + E+QQ + R E+
Sbjct: 733 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
Score = 35.4 bits (80), Expect = 0.10
Identities = 44/200 (22%), Positives = 86/200 (43%), Gaps = 35/200 (17%)
Query: 186 EEENRRLEEKRRAEEAQ------------RQLEQE--RRERELREAARREQRYQEQGGEA 231
E+E +RLE RR EEA+ R+LE+ +RE LR+ + +R ++ E
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 232 SPQ---------SRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSI 282
Q +T + ++E ++ + ++ + ++E V R KQ+E A +
Sbjct: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE--VEARR--KQEEEARRLRWL 651
Query: 283 SSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAV 342
+ + LQK+ + + + AA ++ A+ +E + E+E
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRK---AAEAKRLAEQREQERREQE-----RREQERR 703
Query: 343 YEEPPEQETFYEQPPLVQQQ 362
+E EQE ++ L +Q+
Sbjct: 704 EQERREQERREQERQLAEQE 723
Score = 35.0 bits (79), Expect = 0.14
Identities = 33/127 (25%), Positives = 57/127 (44%), Gaps = 12/127 (9%)
Query: 161 VYQKTNAVSEIKRVGKDSFWA--KAEKEEENRRLEE----KRRAEEAQRQ--LEQERRER 212
+ QK + E K+ A KA+K+ +++EE +++ EEA+R L+QE ER
Sbjct: 599 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 658
Query: 213 E----LREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQGSTCASLQESAVHPRE 268
L++ EQ + EA + EQ++ R E+ QE R+
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718
Query: 269 IFKQKER 275
+ +Q+ R
Sbjct: 719 LAEQERR 725
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 52.4 bits (124), Expect = 8e-07
Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 10/144 (6%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+KEEE RL + A+ Q EQERRE+E RE RREQ +EQ EQ+++
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ--------ERREQERQ 714
Query: 244 VVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPE 303
+ + R + + +E + + QKE+ + + + + ++QL + +
Sbjct: 715 LAEQERRREQERLQAERELQEREKALRLQKEQLQ--RELEEKKKKEEQQRLAERQLQEEQ 772
Query: 304 THFGREPAAAISRPRADLPAEEPA 327
+E A A + + PA
Sbjct: 773 EKKAKEAAGASKALNVTVDVQSPA 796
Score = 37.7 bits (86), Expect = 0.021
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 1/95 (1%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K EK +E R EEK + + A +++E+ R+ E ARR + Q++ E Q +++
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 664
Query: 242 QEVVSRNRN-EQGSTCASLQESAVHPREIFKQKER 275
+E R R + A +E +E +Q+ R
Sbjct: 665 EEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
Score = 37.4 bits (85), Expect = 0.027
Identities = 45/201 (22%), Positives = 87/201 (43%), Gaps = 35/201 (17%)
Query: 185 KEEENRRLEEKRRAEEAQ------------RQLEQE--RRERELREAARREQRYQEQGGE 230
KE+E +RLE RR EEA+ R+LE+ +RE LR+ + +R ++ E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 231 ASPQ---------SRTWEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTS 281
Q +T + ++E ++ + ++ + ++E V R KQ+E A
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE--VEARR--KQEEEARRLRW 646
Query: 282 ISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEA 341
+ + + LQK+ + + + AA ++ A+ +E + E+E
Sbjct: 647 LQQEEEERRHQELLQKKKEEEQERLRK---AAEAKRLAEQREQERREQE-----RREQER 698
Query: 342 VYEEPPEQETFYEQPPLVQQQ 362
+E EQE ++ L +Q+
Sbjct: 699 REQERREQERREQERQLAEQE 719
Score = 37.4 bits (85), Expect = 0.027
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 13/103 (12%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAE----EAQRQL-EQERR------- 210
++ +E KR+ + + E+E + E+ R E E +RQL EQERR
Sbjct: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 728
Query: 211 -ERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQ 252
EREL+E + + +EQ + + E+QQ + R E+
Sbjct: 729 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 771
Score = 35.0 bits (79), Expect = 0.14
Identities = 33/127 (25%), Positives = 57/127 (44%), Gaps = 12/127 (9%)
Query: 161 VYQKTNAVSEIKRVGKDSFWA--KAEKEEENRRLEE----KRRAEEAQRQ--LEQERRER 212
+ QK + E K+ A KA+K+ +++EE +++ EEA+R L+QE ER
Sbjct: 595 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
Query: 213 E----LREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQGSTCASLQESAVHPRE 268
L++ EQ + EA + EQ++ R E+ QE R+
Sbjct: 655 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 714
Query: 269 IFKQKER 275
+ +Q+ R
Sbjct: 715 LAEQERR 721
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 52.0 bits (123), Expect = 1e-06
Identities = 22/55 (40%), Positives = 36/55 (65%), Gaps = 1/55 (1%)
Query: 381 QGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYV 435
+G RA+YD++AA+D E++F +IT ++ D WW+G G G+FP+N+V
Sbjct: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQG-IGLFPSNFV 264
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 52.0 bits (123), Expect = 1e-06
Identities = 49/177 (27%), Positives = 78/177 (44%), Gaps = 22/177 (12%)
Query: 184 EKEEENRRLEEKRRAE-EAQRQLEQERRERELREAAR-----REQRYQEQGGEASPQSRT 237
+++E+ RRLEE++R E EA+RQ E+E+R RE E R R ++ +E+ A + R
Sbjct: 401 QQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 238 WEQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQK 297
E++QE + R E+ LQ+ + +E+AM ++ LQ+
Sbjct: 461 VEREQEYIRRQLEEEQRHLEVLQQQLL--------QEQAMLLECRWREMEEHRQAERLQR 512
Query: 298 QLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYE 354
QL Q + A + + D P S P Q E PE + YE
Sbjct: 513 QLQQEQ--------AYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYE 561
Score = 42.4 bits (98), Expect = 8e-04
Identities = 43/172 (25%), Positives = 68/172 (39%), Gaps = 14/172 (8%)
Query: 182 KAEKEEENRRLEEKRRAEEAQ----RQLEQERRERELREAARREQRYQEQGGEASPQSRT 237
+ E+EE R EEKRR E Q RQLE+E+R E+ + +Q QEQ + R
Sbjct: 445 RKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ----QQLLQEQAMLLECRWRE 500
Query: 238 WEQ--QQEVVSRNRNEQGSTCASLQESAVHPREIFKQK----ERAMSTTSISSPQPGKLR 291
E+ Q E + R ++ + SLQ P Q+ ++ S S +P+P
Sbjct: 501 MEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHY 560
Query: 292 SPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVY 343
P + + + + + E P PS E+V+
Sbjct: 561 EPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVH 612
Score = 29.3 bits (64), Expect = 7.4
Identities = 48/195 (24%), Positives = 75/195 (38%), Gaps = 30/195 (15%)
Query: 187 EENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVS 246
E R + R +E + + E RR++ L+E REQ ++ A Q R EQQ+E
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRI-EQQKEQRR 407
Query: 247 RNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHF 306
R L+E RE +Q+ER Q K R L+++ + E
Sbjct: 408 R-----------LEEQQRREREARRQQEREQRRRE----QEEKRRLEELERRRKEEE--- 449
Query: 307 GREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGS 366
R RA+ Q EEE + E +Q+ EQ L++ +
Sbjct: 450 --------ERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRW--- 498
Query: 367 EHIDHHIQGQGLSGQ 381
++ H Q + L Q
Sbjct: 499 REMEEHRQAERLQRQ 513
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 51.6 bits (122), Expect = 1e-06
Identities = 82/340 (24%), Positives = 138/340 (40%), Gaps = 87/340 (25%)
Query: 184 EKEEENRRLEEKRRAEEAQR--------------QLEQERRERELREAAR--REQRYQEQ 227
+KE+E + +E +++ EEAQR Q ++ +R R+L E + RE+ +++
Sbjct: 632 QKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKK 691
Query: 228 GGEASPQS-------RTWEQQQEVVSR------NRNEQGSTCASLQESA--VHPREIFKQ 272
GE + R + Q QE + E+G S QE+ V+ R ++
Sbjct: 692 DGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPF 751
Query: 273 KERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE--------PAAAISR-PRADLPA 323
+ R+ +I ++ ++ + T G E PA + P ++PA
Sbjct: 752 ESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPA 811
Query: 324 ---------EEPAPS-----TP-PCLVQAEEEAVY---------------EEPPEQETF- 352
PAP TP P V + E + E PE + +
Sbjct: 812 PVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWD 871
Query: 353 --YEQPPL-------VQQQGA-----GSEHIDHHIQGQGLSGQGLCARALYDYQAADDTE 398
QP L ++Q+ A + + GQG +GL A+ALY ++A D
Sbjct: 872 AWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNH 931
Query: 399 ISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 438
++F+ ++IT +E D WW G G G FP +YV+LI
Sbjct: 932 LNFNKNDVITVLEQQDM-WWFG-EVQGQKGWFPKSYVKLI 969
Score = 47.0 bits (110), Expect = 3e-05
Identities = 20/50 (40%), Positives = 32/50 (64%), Gaps = 1/50 (2%)
Query: 388 LYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 437
+YDY A +D E++F+ +I + D WW+G +G G+FP+NYV+L
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG-EVNGQVGLFPSNYVKL 1211
Score = 38.9 bits (89), Expect = 0.009
Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 16/105 (15%)
Query: 155 QAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRER-- 212
QA + ++ +++++R ++ + +++E R+LE +++ E+ QR+LE++R E
Sbjct: 370 QALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEK-QRELERQREEERR 428
Query: 213 ---ELREAARREQRYQEQGGEASPQSRTWE--QQQEVVSRNRNEQ 252
E REAA+RE Q Q WE ++QE++++ EQ
Sbjct: 429 KEIERREAAKRELERQRQ--------LEWERNRRQELLNQRNKEQ 465
Score = 36.2 bits (82), Expect = 0.061
Identities = 27/90 (30%), Positives = 47/90 (52%), Gaps = 3/90 (3%)
Query: 186 EEENRRLEEKRRAEEAQRQLEQER-RERELREAARREQRYQEQGGEASPQSRTWEQQQEV 244
E N LE++R+A Q++ EQER + E E R+E+ QEQ + + ++Q
Sbjct: 359 ERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRE 418
Query: 245 VSRNRNEQGSTCASLQESAVHPREIFKQKE 274
+ R R E+ +E+A RE+ +Q++
Sbjct: 419 LERQREEERRKEIERREAA--KRELERQRQ 446
Score = 36.2 bits (82), Expect = 0.061
Identities = 58/263 (22%), Positives = 98/263 (37%), Gaps = 72/263 (27%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K +E N++ +K+++ EA+R L+Q+ +ER++ E ++++ Q + E Q QQ
Sbjct: 608 KELREIHNKQQLQKQKSMEAER-LKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQ 666
Query: 242 QEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQ 301
++ R R +H E K++E S + GK + +L
Sbjct: 667 EDEHQRPRK-------------LHEEEKLKREE---SVKKKDGEEKGKQEAQDKLGRL-- 708
Query: 302 PETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQ 361
H +EPA +P P P + A+E + +Y
Sbjct: 709 --FHQHQEPA----KPAVQAPWS--TAEKGPLTISAQENV-------KVVYY-------- 745
Query: 362 QGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLI-TGIEVIDEG---- 416
RALY +++ EI+ P +++ E +DE
Sbjct: 746 ------------------------RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGE 781
Query: 417 -WWRGYGPDGHFGMFPANYVELI 438
W G G G FPANY E I
Sbjct: 782 PGWLGGELKGKTGWFPANYAEKI 804
Score = 34.7 bits (78), Expect = 0.18
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 4/58 (6%)
Query: 385 ARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGY----GPDGHFGMFPANYVELI 438
A+ + Y A +++ P LI + GWW G G G FPANYV+L+
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 34.3 bits (77), Expect = 0.23
Identities = 17/51 (33%), Positives = 30/51 (58%), Gaps = 2/51 (3%)
Query: 387 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 437
A+Y Y++++ +++F ++I + D WW G D G+FP+NYV L
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVIL-VTKKDGDWWTGTVGD-KAGVFPSNYVRL 1057
Score = 31.6 bits (70), Expect = 1.5
Identities = 22/82 (26%), Positives = 38/82 (46%), Gaps = 8/82 (9%)
Query: 193 EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQ 252
E+K+R + LE E+R + L E R+EQ Q A + + E+Q++ R
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQ---- 406
Query: 253 GSTCASLQESAVHPREIFKQKE 274
L++ RE+ +Q+E
Sbjct: 407 ----LELEKQLEKQRELERQRE 424
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 51.6 bits (122), Expect = 1e-06
Identities = 82/340 (24%), Positives = 138/340 (40%), Gaps = 87/340 (25%)
Query: 184 EKEEENRRLEEKRRAEEAQR--------------QLEQERRERELREAAR--REQRYQEQ 227
+KE+E + +E +++ EEAQR Q ++ +R R+L E + RE+ +++
Sbjct: 632 QKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKK 691
Query: 228 GGEASPQS-------RTWEQQQEVVSR------NRNEQGSTCASLQESA--VHPREIFKQ 272
GE + R + Q QE + E+G S QE+ V+ R ++
Sbjct: 692 DGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPF 751
Query: 273 KERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE--------PAAAISR-PRADLPA 323
+ R+ +I ++ ++ + T G E PA + P ++PA
Sbjct: 752 ESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPA 811
Query: 324 ---------EEPAPS-----TP-PCLVQAEEEAVY---------------EEPPEQETF- 352
PAP TP P V + E + E PE + +
Sbjct: 812 PVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWD 871
Query: 353 --YEQPPL-------VQQQGA-----GSEHIDHHIQGQGLSGQGLCARALYDYQAADDTE 398
QP L ++Q+ A + + GQG +GL A+ALY ++A D
Sbjct: 872 AWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNH 931
Query: 399 ISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 438
++F+ ++IT +E D WW G G G FP +YV+LI
Sbjct: 932 LNFNKNDVITVLEQQDM-WWFG-EVQGQKGWFPKSYVKLI 969
Score = 47.0 bits (110), Expect = 3e-05
Identities = 20/50 (40%), Positives = 32/50 (64%), Gaps = 1/50 (2%)
Query: 388 LYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 437
+YDY A +D E++F+ +I + D WW+G +G G+FP+NYV+L
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG-EVNGQVGLFPSNYVKL 1211
Score = 38.9 bits (89), Expect = 0.009
Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 16/105 (15%)
Query: 155 QAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRER-- 212
QA + ++ +++++R ++ + +++E R+LE +++ E+ QR+LE++R E
Sbjct: 370 QALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEK-QRELERQREEERR 428
Query: 213 ---ELREAARREQRYQEQGGEASPQSRTWE--QQQEVVSRNRNEQ 252
E REAA+RE Q Q WE ++QE++++ EQ
Sbjct: 429 KEIERREAAKRELERQRQ--------LEWERNRRQELLNQRNKEQ 465
Score = 36.2 bits (82), Expect = 0.061
Identities = 27/90 (30%), Positives = 47/90 (52%), Gaps = 3/90 (3%)
Query: 186 EEENRRLEEKRRAEEAQRQLEQER-RERELREAARREQRYQEQGGEASPQSRTWEQQQEV 244
E N LE++R+A Q++ EQER + E E R+E+ QEQ + + ++Q
Sbjct: 359 ERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRE 418
Query: 245 VSRNRNEQGSTCASLQESAVHPREIFKQKE 274
+ R R E+ +E+A RE+ +Q++
Sbjct: 419 LERQREEERRKEIERREAA--KRELERQRQ 446
Score = 36.2 bits (82), Expect = 0.061
Identities = 58/263 (22%), Positives = 98/263 (37%), Gaps = 72/263 (27%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K +E N++ +K+++ EA+R L+Q+ +ER++ E ++++ Q + E Q QQ
Sbjct: 608 KELREIHNKQQLQKQKSMEAER-LKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQ 666
Query: 242 QEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQ 301
++ R R +H E K++E S + GK + +L
Sbjct: 667 EDEHQRPRK-------------LHEEEKLKREE---SVKKKDGEEKGKQEAQDKLGRL-- 708
Query: 302 PETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQ 361
H +EPA +P P P + A+E + +Y
Sbjct: 709 --FHQHQEPA----KPAVQAPWS--TAEKGPLTISAQENV-------KVVYY-------- 745
Query: 362 QGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLI-TGIEVIDEG---- 416
RALY +++ EI+ P +++ E +DE
Sbjct: 746 ------------------------RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGE 781
Query: 417 -WWRGYGPDGHFGMFPANYVELI 438
W G G G FPANY E I
Sbjct: 782 PGWLGGELKGKTGWFPANYAEKI 804
Score = 34.7 bits (78), Expect = 0.18
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 4/58 (6%)
Query: 385 ARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGY----GPDGHFGMFPANYVELI 438
A+ + Y A +++ P LI + GWW G G G FPANYV+L+
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 34.3 bits (77), Expect = 0.23
Identities = 17/51 (33%), Positives = 30/51 (58%), Gaps = 2/51 (3%)
Query: 387 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 437
A+Y Y++++ +++F ++I + D WW G D G+FP+NYV L
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVIL-VTKKDGDWWTGTVGD-KAGVFPSNYVRL 1057
Score = 31.6 bits (70), Expect = 1.5
Identities = 22/82 (26%), Positives = 38/82 (46%), Gaps = 8/82 (9%)
Query: 193 EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQ 252
E+K+R + LE E+R + L E R+EQ Q A + + E+Q++ R
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQ---- 406
Query: 253 GSTCASLQESAVHPREIFKQKE 274
L++ RE+ +Q+E
Sbjct: 407 ----LELEKQLEKQRELERQRE 424
>gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
Length = 625
Score = 51.2 bits (121), Expect = 2e-06
Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 13/144 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
E+ E+ R LE+ RRA AQ + + RR RE REAARR QR E+ E + R ++Q
Sbjct: 395 EEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEE---RRRELAERQG 451
Query: 244 VVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPE 303
++ R R E+ + L++ + + KQ+E + Q G+ R+ ++++ Q
Sbjct: 452 LLRRERAERAAREDRLRK--LQQEQNLKQREEGL--------QEGRERAEQIRRERAQRA 501
Query: 304 THFGREPAAAISRPRADLPAEEPA 327
+ + R + +L E A
Sbjct: 502 ARAKQRQEGQLQREKRELSRAERA 525
Score = 41.2 bits (95), Expect = 0.002
Identities = 35/113 (30%), Positives = 51/113 (45%), Gaps = 10/113 (8%)
Query: 180 WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGE-ASPQSRTW 238
WA +E RR E+R A +RQ + ER E RE A R+ + + E A+ + R
Sbjct: 410 WAAQVEERRGRRGREEREAAR-RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLR 468
Query: 239 EQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLR 291
+ QQE + R E LQE +I ++ERA Q G+L+
Sbjct: 469 KLQQEQNLKQREE------GLQEGRERAEQI--RRERAQRAARAKQRQEGQLQ 513
Score = 35.8 bits (81), Expect = 0.079
Identities = 44/151 (29%), Positives = 62/151 (41%), Gaps = 20/151 (13%)
Query: 183 AEKEEENRRLEEKRRAE---EAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
A +EE LE++ A E QR ++RRERE RE +QR EQG R W
Sbjct: 362 ARHQEELLLLEQRAAAHGQWELQRVHAKQRREREERE----KQRALEQG------RRAWA 411
Query: 240 QQQEVVSRNRNEQGSTCA-----SLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF 294
Q E R + A + S RE+ +++ + + + +LR
Sbjct: 412 AQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQ 471
Query: 295 LQKQLTQPETHF--GREPAAAISRPRADLPA 323
++ L Q E GRE A I R RA A
Sbjct: 472 QEQNLKQREEGLQEGRERAEQIRRERAQRAA 502
Score = 33.5 bits (75), Expect = 0.39
Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLE-QERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
+ E +E R E+ R E AQR ++R+E +L+ R R + EA Q RT +Q
Sbjct: 479 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 538
Query: 241 QQE 243
+QE
Sbjct: 539 RQE 541
Score = 30.8 bits (68), Expect = 2.5
Identities = 35/155 (22%), Positives = 63/155 (40%), Gaps = 14/155 (9%)
Query: 144 KESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRR-------LEEKR 196
+E R + G +A V ++ +R + E+ EE RR L +
Sbjct: 397 REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRE 456
Query: 197 RAEEAQR-------QLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNR 249
RAE A R Q EQ ++RE RE+ Q + A +R ++Q+ + R +
Sbjct: 457 RAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK 516
Query: 250 NEQGSTCASLQESAVHPREIFKQKERAMSTTSISS 284
E + E+ + R +++ER +S+ +
Sbjct: 517 RELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
>gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 51.2 bits (121), Expect = 2e-06
Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 13/144 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
E+ E+ R LE+ RRA AQ + + RR RE REAARR QR E+ E + R ++Q
Sbjct: 397 EEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEE---RRRELAERQG 453
Query: 244 VVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPE 303
++ R R E+ + L++ + + KQ+E + Q G+ R+ ++++ Q
Sbjct: 454 LLRRERAERAAREDRLRK--LQQEQNLKQREEGL--------QEGRERAEQIRRERAQRA 503
Query: 304 THFGREPAAAISRPRADLPAEEPA 327
+ + R + +L E A
Sbjct: 504 ARAKQRQEGQLQREKRELSRAERA 527
Score = 41.2 bits (95), Expect = 0.002
Identities = 35/113 (30%), Positives = 51/113 (45%), Gaps = 10/113 (8%)
Query: 180 WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGE-ASPQSRTW 238
WA +E RR E+R A +RQ + ER E RE A R+ + + E A+ + R
Sbjct: 412 WAAQVEERRGRRGREEREAAR-RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLR 470
Query: 239 EQQQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLR 291
+ QQE + R E LQE +I ++ERA Q G+L+
Sbjct: 471 KLQQEQNLKQREE------GLQEGRERAEQI--RRERAQRAARAKQRQEGQLQ 515
Score = 35.8 bits (81), Expect = 0.079
Identities = 44/151 (29%), Positives = 62/151 (41%), Gaps = 20/151 (13%)
Query: 183 AEKEEENRRLEEKRRAE---EAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
A +EE LE++ A E QR ++RRERE RE +QR EQG R W
Sbjct: 364 ARHQEELLLLEQRAAAHGQWELQRVHAKQRREREERE----KQRALEQG------RRAWA 413
Query: 240 QQQEVVSRNRNEQGSTCA-----SLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF 294
Q E R + A + S RE+ +++ + + + +LR
Sbjct: 414 AQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQ 473
Query: 295 LQKQLTQPETHF--GREPAAAISRPRADLPA 323
++ L Q E GRE A I R RA A
Sbjct: 474 QEQNLKQREEGLQEGRERAEQIRRERAQRAA 504
Score = 33.5 bits (75), Expect = 0.39
Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLE-QERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
+ E +E R E+ R E AQR ++R+E +L+ R R + EA Q RT +Q
Sbjct: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
Query: 241 QQE 243
+QE
Sbjct: 541 RQE 543
Score = 30.8 bits (68), Expect = 2.5
Identities = 35/155 (22%), Positives = 63/155 (40%), Gaps = 14/155 (9%)
Query: 144 KESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRR-------LEEKR 196
+E R + G +A V ++ +R + E+ EE RR L +
Sbjct: 399 REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRE 458
Query: 197 RAEEAQR-------QLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNR 249
RAE A R Q EQ ++RE RE+ Q + A +R ++Q+ + R +
Sbjct: 459 RAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK 518
Query: 250 NEQGSTCASLQESAVHPREIFKQKERAMSTTSISS 284
E + E+ + R +++ER +S+ +
Sbjct: 519 RELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,534,173
Number of Sequences: 37866
Number of extensions: 1061963
Number of successful extensions: 16327
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 471
Number of HSP's successfully gapped in prelim test: 716
Number of HSP's that attempted gapping in prelim test: 6539
Number of HSP's gapped (non-prelim): 5054
length of query: 439
length of database: 18,247,518
effective HSP length: 105
effective length of query: 334
effective length of database: 14,271,588
effective search space: 4766710392
effective search space used: 4766710392
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.