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Search of human proteins with 166706887
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166706887 syncoilin, intermediate filament 1 isoform 1 [Homo
sapiens]
(482 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166706887 syncoilin, intermediate filament 1 isoform 1 [Homo ... 931 0.0
gi|239787821 syncoilin, intermediate filament 1 isoform 2 [Homo ... 878 0.0
gi|14249342 internexin neuronal intermediate filament protein, a... 103 3e-22
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 96 6e-20
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 96 6e-20
gi|21264345 peripherin [Homo sapiens] 94 3e-19
gi|62414289 vimentin [Homo sapiens] 91 3e-18
gi|55749932 desmin [Homo sapiens] 86 6e-17
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 81 2e-15
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 80 3e-15
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 79 9e-15
gi|221139761 zinc finger protein 853 [Homo sapiens] 78 2e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 77 3e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 77 3e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 74 2e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 74 2e-13
gi|131412225 keratin 13 isoform a [Homo sapiens] 74 3e-13
gi|4504919 keratin 8 [Homo sapiens] 74 4e-13
gi|14917115 keratin 31 [Homo sapiens] 74 4e-13
gi|10337581 type I hair keratin 3B [Homo sapiens] 73 5e-13
gi|153791158 keratin 75 [Homo sapiens] 73 5e-13
gi|28173564 keratin 73 [Homo sapiens] 72 9e-13
gi|131412228 keratin 13 isoform b [Homo sapiens] 72 1e-12
gi|119395754 keratin 5 [Homo sapiens] 72 1e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 71 2e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 71 2e-12
gi|14917117 keratin 33A [Homo sapiens] 71 2e-12
gi|67782365 keratin 7 [Homo sapiens] 70 4e-12
gi|14917119 keratin 34 [Homo sapiens] 70 4e-12
gi|31982906 cingulin-like 1 [Homo sapiens] 70 4e-12
>gi|166706887 syncoilin, intermediate filament 1 isoform 1 [Homo
sapiens]
Length = 482
Score = 931 bits (2407), Expect = 0.0
Identities = 482/482 (100%), Positives = 482/482 (100%)
Query: 1 MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY 60
MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY
Sbjct: 1 MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY 60
Query: 61 LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF 120
LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF
Sbjct: 61 LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF 120
Query: 121 VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ 180
VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ
Sbjct: 121 VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ 180
Query: 181 QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR 240
QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR
Sbjct: 181 QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR 240
Query: 241 LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE 300
LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE
Sbjct: 241 LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE 300
Query: 301 QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA 360
QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA
Sbjct: 301 QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA 360
Query: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER
Sbjct: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
Query: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMETQSQG 480
QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMETQSQG
Sbjct: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMETQSQG 480
Query: 481 AV 482
AV
Sbjct: 481 AV 482
>gi|239787821 syncoilin, intermediate filament 1 isoform 2 [Homo
sapiens]
Length = 476
Score = 878 bits (2269), Expect = 0.0
Identities = 454/456 (99%), Positives = 454/456 (99%)
Query: 1 MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY 60
MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY
Sbjct: 1 MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY 60
Query: 61 LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF 120
LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF
Sbjct: 61 LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF 120
Query: 121 VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ 180
VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ
Sbjct: 121 VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ 180
Query: 181 QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR 240
QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR
Sbjct: 181 QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR 240
Query: 241 LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE 300
LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE
Sbjct: 241 LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE 300
Query: 301 QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA 360
QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA
Sbjct: 301 QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA 360
Query: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER
Sbjct: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
Query: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAML 456
QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYK L
Sbjct: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCL 456
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 103 bits (257), Expect = 3e-22
Identities = 78/305 (25%), Positives = 150/305 (49%), Gaps = 18/305 (5%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLR----EPAL------QEVQQVHQDIL 219
E L+ L RF ++ V QLE + L EL LR EP+ +E++ + +
Sbjct: 96 EQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLE 155
Query: 220 AAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTT 279
A +QA LERDGL EE++ ++ + + ++ + L+ +Q+DV R L
Sbjct: 156 EASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEK 215
Query: 280 RATQLSEELAQLRDAYQKQKEQLRQQLEAPP--------SQRDGHFLQESRRLSAQFENL 331
+ L +ELA +R + ++ +L L+A + R + AQ+E+L
Sbjct: 216 KVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESL 275
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRN 391
A++ Q EE Y+ +F L E+ T+A++ ++ EI E + L+ E LR N +
Sbjct: 276 AAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANES 335
Query: 392 LEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELST 451
LE QI + ++ EV Y++ + ++E R ++ + ++ +++ ++++L E++
Sbjct: 336 LERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAA 395
Query: 452 YKAML 456
Y+ +L
Sbjct: 396 YRKLL 400
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 96.3 bits (238), Expect = 6e-20
Identities = 82/358 (22%), Positives = 159/358 (44%), Gaps = 26/358 (7%)
Query: 119 QFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNP-----EESLRAEQSPSVEENLSIEDLE 173
+ + G + PG+ P G ++ A P + SL + +E + E E
Sbjct: 19 EMMVGGLAPGRRLGP------GTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAE 72
Query: 174 LLE--GRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLH------ 225
++E RF ++ V LE++ L EL LR ++ V+Q L +L
Sbjct: 73 MMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTA 132
Query: 226 --AQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQ 283
A+ E+ERD L +++ V+QKL T + + L +Q+ + R L +
Sbjct: 133 NSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIES 192
Query: 284 LSEELAQLRDAYQKQKEQL-----RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQD 338
L EE+ LR ++++ +L RQQ+ + + Q+E + + + +
Sbjct: 193 LEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHE 252
Query: 339 LEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIAL 398
EE Y +F L + + L++ + E + + L+ L + LR N +LE Q+
Sbjct: 253 AEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMRE 312
Query: 399 VRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAML 456
++ E Y+E L +EE + L++ + Q+ +++ ++L+L E++TY+ +L
Sbjct: 313 QEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLL 370
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 96.3 bits (238), Expect = 6e-20
Identities = 82/358 (22%), Positives = 159/358 (44%), Gaps = 26/358 (7%)
Query: 119 QFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNP-----EESLRAEQSPSVEENLSIEDLE 173
+ + G + PG+ P G ++ A P + SL + +E + E E
Sbjct: 19 EMMVGGLAPGRRLGP------GTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAE 72
Query: 174 LLE--GRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLH------ 225
++E RF ++ V LE++ L EL LR ++ V+Q L +L
Sbjct: 73 MMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTA 132
Query: 226 --AQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQ 283
A+ E+ERD L +++ V+QKL T + + L +Q+ + R L +
Sbjct: 133 NSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIES 192
Query: 284 LSEELAQLRDAYQKQKEQL-----RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQD 338
L EE+ LR ++++ +L RQQ+ + + Q+E + + + +
Sbjct: 193 LEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHE 252
Query: 339 LEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIAL 398
EE Y +F L + + L++ + E + + L+ L + LR N +LE Q+
Sbjct: 253 AEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMRE 312
Query: 399 VRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAML 456
++ E Y+E L +EE + L++ + Q+ +++ ++L+L E++TY+ +L
Sbjct: 313 QEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLL 370
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 94.0 bits (232), Expect = 3e-19
Identities = 71/302 (23%), Positives = 151/302 (50%), Gaps = 15/302 (4%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLR--EPAL------QEVQQVHQDILAA 221
++L+ L RF ++ V LE++ L EL R EPA QE++++ +++
Sbjct: 99 QELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELL 158
Query: 222 YKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRA 281
+ + ++ERDGL E++ +KQ+L + T++ ++ L ++DV R L +
Sbjct: 159 GRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKI 218
Query: 282 TQLSEELAQLRDAYQKQKEQLRQQLEAPPSQR-------DGHFLQESRRLSAQFENLMAE 334
L +E+ L+ ++++ L+ +E+ Q+ R + AQ+E++ A+
Sbjct: 219 ESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAK 278
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ Q+ EE Y+ ++ L + +AL++ + E+ E + ++ L E LR N L
Sbjct: 279 NLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLR 338
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKA 454
Q+ + ++ E Y+ +EE RQL+ + ++ +E+ ++++L E++TY+
Sbjct: 339 QLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRK 398
Query: 455 ML 456
+L
Sbjct: 399 LL 400
Score = 32.7 bits (73), Expect = 0.75
Identities = 24/100 (24%), Positives = 46/100 (46%), Gaps = 6/100 (6%)
Query: 367 EIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRN 426
E+QE+ + + R L QN L +++ R + Q +Q R+LR
Sbjct: 100 ELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQ------ELRELRR 153
Query: 427 GVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADA 466
++L ++ ++ R LAE+L+ K L ++ ++ DA
Sbjct: 154 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDA 193
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 90.5 bits (223), Expect = 3e-18
Identities = 66/299 (22%), Positives = 148/299 (49%), Gaps = 13/299 (4%)
Query: 171 DLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPAL--------QEVQQVHQDILAAY 222
+L+ L RF + V LE++ L+ EL L+ +E++++ + +
Sbjct: 106 ELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLT 165
Query: 223 KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRAT 282
A+ E+ERD L E+I +++KL + + + L+ +QDV + R L +
Sbjct: 166 NDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVE 225
Query: 283 QLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQES-----RRLSAQFENLMAESRQ 337
L EE+A L+ ++++ ++L+ Q++ Q D + R + Q+E++ A++ Q
Sbjct: 226 SLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQ 285
Query: 338 DLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIA 397
+ EE Y+ +F L E AL++ + E E + ++ L E L+ N +LE Q+
Sbjct: 286 EAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMR 345
Query: 398 LVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAML 456
+ + E Y++ + +++ + ++ + ++ +++ ++++L E++TY+ +L
Sbjct: 346 EMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLL 404
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 86.3 bits (212), Expect = 6e-17
Identities = 66/299 (22%), Positives = 145/299 (48%), Gaps = 13/299 (4%)
Query: 171 DLELLEGRFQQCVQAVAQLEEERDQLIHELVLL--REPAL------QEVQQVHQDILAAY 222
+L+ L RF ++ V LE++ L E+ L REP +E++++ + +
Sbjct: 111 ELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPTRVAELYEEELRELRRQVEVLT 170
Query: 223 KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRAT 282
A+ ++ERD L ++++ +K KL + + + L + DV R L R
Sbjct: 171 NQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIE 230
Query: 283 QLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQES-----RRLSAQFENLMAESRQ 337
L+EE+A L+ ++++ +L+ QL+ Q + + R + AQ+E + A++
Sbjct: 231 SLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNIS 290
Query: 338 DLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIA 397
+ EE Y+ + L + AL++ + E+ E + ++ E L+ N +L Q+
Sbjct: 291 EAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMR 350
Query: 398 LVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAML 456
+ + E Y++ + +EE R L++ + ++ +++ ++++L E++TY+ +L
Sbjct: 351 ELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLL 409
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 81.3 bits (199), Expect = 2e-15
Identities = 72/312 (23%), Positives = 136/312 (43%), Gaps = 29/312 (9%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPAL----------QEVQQVHQDIL 219
E L+ L RF + V QLE L E LR+ +EV+++ +L
Sbjct: 99 EQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVL 158
Query: 220 AAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV--- 276
Q LE++ L E+I V+Q+L ++ + + E + +A+FA E
Sbjct: 159 RLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQ----REEAEAAARALARFAQEAEAARV 214
Query: 277 -LTTRATQLSEELAQLRDAYQKQKEQLRQQLEA--------PPSQRDG---HFLQESRRL 324
L +A L EE LR +Q++ +L Q++ RD R +
Sbjct: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
Query: 325 SAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQ 384
AQ E +S EE + + RL E + T A++ Q EI E + L+ E
Sbjct: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
Query: 385 LRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLS 444
L+ +LE Q + + + ++ Y+E +++++ R + + Q ++ +++ ++++
Sbjct: 335 LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
Query: 445 LAEELSTYKAML 456
L E++ Y+ +L
Sbjct: 395 LDIEIAAYRKLL 406
Score = 47.0 bits (110), Expect = 4e-05
Identities = 41/147 (27%), Positives = 73/147 (49%), Gaps = 19/147 (12%)
Query: 303 RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKAL- 361
++QL+A + R ++ + R+L A +L E+ L +++AG A+
Sbjct: 98 KEQLQAL-NDRFAGYIDKVRQLEAHNRSLEGEAAA-------------LRQQQAGRSAMG 143
Query: 362 QRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQ 421
+ + E++EM+ A+ L A QLRL+ +L + IA VRQ+ D+E + Q EE E
Sbjct: 144 ELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEAR----QREEAEAAA 199
Query: 422 RQLRNGVQLQQQKNKEMEQLRLSLAEE 448
R L Q + ++++ +L EE
Sbjct: 200 RALARFAQEAEAARVDLQKKAQALQEE 226
Score = 30.4 bits (67), Expect = 3.7
Identities = 61/321 (19%), Positives = 132/321 (41%), Gaps = 52/321 (16%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEE-RDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQA 228
E++ L G+ Q A AQ++ E RD L ++ AL+E++ + L ++
Sbjct: 236 EEVGELLGQIQGSGAAQAQMQAETRDALKCDVT----SALREIRAQLEGHAVQSTLQSEE 291
Query: 229 --ELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSE 286
+ D L E ++ + +E Y+ QL+ R ++ E
Sbjct: 292 WFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL------------------E 333
Query: 287 ELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQ 346
L +D+ ++Q+ +L + +A + + + ++L A+ N E L E +
Sbjct: 334 ALKSTKDSLERQRSELEDRHQADIAS----YQEAIQQLDAELRNTKWEMAAQLREYQDLL 389
Query: 347 FLRLLERKE--AGTKALQRTQAEIQ------EMKEALRPLQAEARQLRLQNRNLEDQIAL 398
+++ E A K L+ + I + E L + + + +++++ E++I +
Sbjct: 390 NVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKS---EEKIKV 446
Query: 399 VRQKRDE--------EVQQYREQLEEMEERQRQLRNGVQLQQQKNKEM----EQLRLSLA 446
V + E E Q E++ E EE++ + G + + + +E E+ + A
Sbjct: 447 VEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPA 506
Query: 447 EELSTYKAMLLPKSLEQADAP 467
EE ++ + E+A +P
Sbjct: 507 EEAASPEKEAKSPVKEEAKSP 527
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 80.5 bits (197), Expect = 3e-15
Identities = 56/303 (18%), Positives = 146/303 (48%), Gaps = 16/303 (5%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPAL----------QEVQQVHQDIL 219
E L+ L RF ++ V LE++ ++ E+ LR+ QE++++ +
Sbjct: 103 EQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLE 162
Query: 220 AAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTT 279
AQ +L+ D L E+I +K++ + + + + ++D+ + + + L
Sbjct: 163 MVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDK 222
Query: 280 RATQLSEELAQLRDAYQKQKEQLRQQLEAP--PSQRDGHFLQE----SRRLSAQFENLMA 333
+ L +E+A LR ++++ L Q++A +R + + + + +Q E+
Sbjct: 223 KVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSD 282
Query: 334 ESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLE 393
++ EE ++ ++ +L E E +A++ + EI E + L+ E +R +LE
Sbjct: 283 QNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLE 342
Query: 394 DQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYK 453
Q++ + ++ + ++ Y++ ++++E R + + ++ +++ ++++L E++ Y+
Sbjct: 343 RQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYR 402
Query: 454 AML 456
+L
Sbjct: 403 KLL 405
Score = 44.3 bits (103), Expect = 2e-04
Identities = 49/210 (23%), Positives = 88/210 (41%), Gaps = 36/210 (17%)
Query: 288 LAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQ-DLEEEY-EP 345
L Q + + + LRQ+ +A +Q + QE R L A E + E Q L+ ++ E
Sbjct: 122 LEQQNKEIEAEIQALRQK-QASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEE 180
Query: 346 QFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDE 405
RL ER E + T+A I+ +++ + +L + ++L+D++A +R +E
Sbjct: 181 DIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEE 240
Query: 406 EVQQYREQLEEME---ERQRQLRNGV---------QLQQQKNKEMEQLR----------- 442
EV Q++ ER+ L+ + QL+ ++ M Q
Sbjct: 241 EVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT 300
Query: 443 ----------LSLAEELSTYKAMLLPKSLE 462
S EE++ Y+ L KS+E
Sbjct: 301 EAAEQNKEAIRSAKEEIAEYRRQLQSKSIE 330
Score = 38.9 bits (89), Expect = 0.010
Identities = 65/390 (16%), Positives = 158/390 (40%), Gaps = 60/390 (15%)
Query: 135 HVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQ------ 188
H+ E + + + S + +R++ ++N+ + E + R+ + +A Q
Sbjct: 253 HITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAE-EWFKCRYAKLTEAAEQNKEAIR 311
Query: 189 -----LEEERDQLIHELVLLR---------EPALQEVQQVHQDILAAYKLHAQAELERDG 234
+ E R QL + + L E L ++++ H L++Y+ Q
Sbjct: 312 SAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQ------ 365
Query: 235 LREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDA 294
L E+R K ++ + +E YQ L + + A +R++L T+ S +
Sbjct: 366 LENELRGTKWEMARHLRE---YQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGP 422
Query: 295 YQKQKEQL-------RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQF 347
+ + + ++EAP + F++E E + + + ++EE
Sbjct: 423 LYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIE-----ETKVEDEKSEMEEALTAIT 477
Query: 348 LRLL-----ERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQK 402
L E+KEA + + +AE +E+ P++A A +++ + E++ ++
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 537
Query: 403 RDEE------------VQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
++E ++ + EE E+ + + + ++ + KE +++ +EE++
Sbjct: 538 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE-EKSEEVA 596
Query: 451 TYKAMLLPKSLEQADAPTSQAGGMETQSQG 480
T + ++ +E+ + S + +G
Sbjct: 597 TKEELVADAKVEKPEKAKSPVPKSPVEEKG 626
Score = 31.2 bits (69), Expect = 2.2
Identities = 39/163 (23%), Positives = 68/163 (41%), Gaps = 13/163 (7%)
Query: 73 VQETEKAEEALYIEEAMQP-DEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPT 131
++ET+ +E +EEA+ E L V +E +E + V P K T
Sbjct: 457 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 516
Query: 132 SPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIED--LELLEGRFQQCVQAVAQL 189
+PE EGE + EE +S EE S ++ E EG Q+ + A+
Sbjct: 517 APEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE-QEEGETEAEA 575
Query: 190 EEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELER 232
E E + E ++V++ +++ +L A A++E+
Sbjct: 576 EGEEAEAKEE---------KKVEEKSEEVATKEELVADAKVEK 609
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 79.0 bits (193), Expect = 9e-15
Identities = 69/327 (21%), Positives = 153/327 (46%), Gaps = 32/327 (9%)
Query: 149 SNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLR---- 204
SN +S+R ++ +++ L RF ++ V +LE++ L EL++LR
Sbjct: 80 SNDLKSIRTQEKAQLQD---------LNDRFASFIERVHELEQQNKVLEAELLVLRQKHS 130
Query: 205 EPAL------QEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQY 258
EP+ QE++ + A + ER+GL E +R ++ + +E V +
Sbjct: 131 EPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARY----EEEVLSRE 186
Query: 259 QLECRQQDVAQFAD----FREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRD 314
E R + + AD R L R L +E++ L+ ++++ +L+ Q++ +
Sbjct: 187 DAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVE 246
Query: 315 GHFLQES-----RRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQ 369
+ + + AQ+E L A++ Q+ EE ++ +F L E T A++ + E+
Sbjct: 247 MDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVS 306
Query: 370 EMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQ 429
E + L+ E R N LE Q+ + K++ ++ ++ + ++E R ++ +
Sbjct: 307 ESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMA 366
Query: 430 LQQQKNKEMEQLRLSLAEELSTYKAML 456
++ +++ ++++L E++ Y+ +L
Sbjct: 367 RYLKEYQDLLNVKMALDIEIAAYRKLL 393
Score = 35.4 bits (80), Expect = 0.12
Identities = 47/217 (21%), Positives = 86/217 (39%), Gaps = 43/217 (19%)
Query: 279 TRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQD 338
++ +S +L +R + Q + L + R F++ L Q + L AE
Sbjct: 74 SQVAAISNDLKSIRTQEKAQLQDL--------NDRFASFIERVHELEQQNKVLEAELLVL 125
Query: 339 LEEEYEPQFLRLLERKEA---------GTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
++ EP R L +E T Q Q E + ++E LR LQA + L
Sbjct: 126 RQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSR 185
Query: 390 RNLE----------DQIALVRQKRDEEVQQYREQL--------EEMEERQRQLRNGVQLQ 431
+ E D+ AL R + ++ + +++ EE+ E Q Q++
Sbjct: 186 EDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQ-----Y 240
Query: 432 QQKNKEMEQLRLSLAEELSTYKAM---LLPKSLEQAD 465
Q + EM+ + L+ L +A L K+++ A+
Sbjct: 241 AQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAE 277
Score = 32.3 bits (72), Expect = 0.98
Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 6/106 (5%)
Query: 363 RTQ--AEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
RTQ A++Q++ + +L QN+ LE ++ ++RQK E ++R E+
Sbjct: 87 RTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEP-SRFRAL---YEQE 142
Query: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADA 466
R LR + + + ++ R L E L +A + L + DA
Sbjct: 143 IRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDA 188
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 77.8 bits (190), Expect = 2e-14
Identities = 91/382 (23%), Positives = 172/382 (45%), Gaps = 31/382 (8%)
Query: 95 LHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEES 154
LH PGN T +E + +E G P P+ + E+ P+E
Sbjct: 2 LHQPTPGNRGLTARMEVGPATETFVLELQCLEDGGP-GPDTLSGGSGGSESQEEEEPQER 60
Query: 155 LRAEQSPSVEENLSIEDL--ELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
+ Q P+V + ++ E G+ + +Q + Q E + Q HE + +P L+ Q
Sbjct: 61 NSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQ 120
Query: 213 QVHQD---ILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQ 269
Q QD L+ + + L+ E++L+ Q+ ++ + V Q +L+ +QQ+ Q
Sbjct: 121 QPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQ-QLQPQQVQEQQRLQ-QQQEQLQ 178
Query: 270 FADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQ--LEAPPSQRDGHFLQESRRLSAQ 327
+E + + ++ Q + Q+Q+EQL+QQ L+ + F Q+ +L Q
Sbjct: 179 TQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQ 238
Query: 328 FENLMAESRQDLEEEYEPQFL-----RLLERKEAGTKAL----QRTQAEIQEMKEALRPL 378
+ L+ + + L+++ Q +LLE+++A + Q+ Q + Q+ ++ L+
Sbjct: 239 QQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQ 298
Query: 379 QAEARQLRLQNRNLE----DQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
Q + +Q +LQ LE +++ L D +Q EQ + ERQ++L ++
Sbjct: 299 QEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQEL--------ER 350
Query: 435 NKEMEQLRLSLAEELSTYKAML 456
+E QL+L L EEL + L
Sbjct: 351 QQEQRQLQLKLQEELQQLEQQL 372
Score = 58.5 bits (140), Expect = 1e-08
Identities = 53/208 (25%), Positives = 98/208 (47%), Gaps = 11/208 (5%)
Query: 279 TRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQ--FENLMAESR 336
TR Q +L QL + Q++ +QL+ P + LQ+ + Q L E
Sbjct: 82 TRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLE---LQQQPQQDGQQQLSQLQQEKH 138
Query: 337 QDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQI 396
Q + + L+L+ +++ + Q +Q+ +E L+ QA+ +Q+ Q L+ Q+
Sbjct: 139 QSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQV 198
Query: 397 A----LVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEE-LST 451
L +Q+ + QQ +Q E+++++Q Q + QLQQQ+ + Q + L ++ L
Sbjct: 199 QEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQ-QQQEQLQQQQQLLLLQQQGQLQQQLLQQ 257
Query: 452 YKAMLLPKSLEQADAPTSQAGGMETQSQ 479
+A L + LEQ A Q ++ Q Q
Sbjct: 258 QQAQLQQQLLEQQQAQLQQQLLLQQQEQ 285
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 77.4 bits (189), Expect = 3e-14
Identities = 113/499 (22%), Positives = 214/499 (42%), Gaps = 63/499 (12%)
Query: 16 AARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDL-----DET 70
A + R EA + K + +L+ A AL E L ++ L + + + DL D
Sbjct: 1468 ADERDRAEAEAR-EKETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 71 LYVQETEKAEEAL--YIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF-----VEG 123
V E EK++ AL +EE E L E + + +E + + QF
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 124 PVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL-----LEGR 178
K + ++E ET E+ + +L A +E +L +DLEL ++GR
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDL--KDLELQADSAIKGR 1640
Query: 179 FQQCVQAVAQLEEERDQLIHELVLLREPALQ-----------------EVQQVHQDILAA 221
++ ++ + +L+ + EL R + ++ Q+ +D+ AA
Sbjct: 1641 -EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 222 YKLHAQAELERDGLREEI-------RLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFR 274
+ QA+LE++ L EE+ ++ + ++ + +LE Q ++ +D
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
T +A QLS ELA R QK E RQQLE + + + ++F++ +A
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ + E Q + K+A TK+L++ +++E+ LQ E R + +
Sbjct: 1819 LEAKIAQ-LEEQVEQEAREKQAATKSLKQKDKKLKEIL-----LQVE------DERKMAE 1866
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKA 454
Q +K + V+Q + QLEE EE +++ + Q++ E + ++ E++ K+
Sbjct: 1867 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 455 MLLPKSLEQADAPTSQAGG 473
L + E + P+ ++GG
Sbjct: 1927 K-LRRGNETSFVPSRRSGG 1944
Score = 62.8 bits (151), Expect = 7e-10
Identities = 85/414 (20%), Positives = 187/414 (45%), Gaps = 40/414 (9%)
Query: 38 AEALNPEVTLSSEGSLNLEDILY-----LEDTGDLDETLYVQETEKAEEALYIEEAMQPD 92
AEA V L+++ LE+IL+ LE+ D + L + + A++ L +EE ++ +
Sbjct: 904 AEAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 93 EALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPE 152
EA + + +E+ T +I+ +E + V+ + E+ E
Sbjct: 963 EA--------ARQKLQLEKVTAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLE 1005
Query: 153 ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
E + + EE ++L L+ + + + + ++ ++ EL L+ +
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 213 QVHQDILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
H+ I L AQ AEL+ ++E L + L ++ E L+ ++ +
Sbjct: 1066 DFHEQIA---DLQAQIAELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHF--LQESRRLSAQFE 329
D +E L SE A R+ +KQK L ++LEA ++ + + L A+ E
Sbjct: 1122 DLQEDLD------SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 330 NLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
+ ++ L+EE ++ E ++ +A++ ++++ K A L + L +N
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 390 RNLEDQIALVRQKRDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLR 442
+L ++ ++ Q + +EV+ +++LE +++E Q + +G + + + N ++ +L+
Sbjct: 1234 ADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Score = 58.9 bits (141), Expect = 1e-08
Identities = 77/328 (23%), Positives = 144/328 (43%), Gaps = 47/328 (14%)
Query: 141 ETVTRAEKSNPE-ESLRAEQSPSVEE-NLSIEDLEL---LEGRFQQCVQAVAQLEEERDQ 195
+T R +K+ E + L + S EE NL E L+ L ++ +A ++E ++
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF--KVTKEC 253
++HE+ E L+E + Q + A K AQ L+ + EE +QKL KVT E
Sbjct: 923 ILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 978
Query: 254 VAYQYQLECRQQDVA--QFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPS 311
+ + E D + + R++L R + L+ LA+ + K +L+ + E+ S
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMIS 1037
Query: 312 QRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEM 371
+ + +E + SRQ+LE+ L+RK G + +
Sbjct: 1038 ELEVRLKKEEK------------SRQELEK---------LKRKLEG---------DASDF 1067
Query: 372 KEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYR---EQLEEMEERQRQLRNGV 428
E + LQA+ +L++Q E+++ + D+E+ Q +++ E+E L+ +
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKAML 456
++ + E+ + L EEL K L
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTEL 1155
Score = 57.4 bits (137), Expect = 3e-08
Identities = 78/346 (22%), Positives = 151/346 (43%), Gaps = 26/346 (7%)
Query: 141 ETVTRAEKSNPEESLRAEQSPSVEENLSIED-----LEL----LEGRFQQCVQAVAQLEE 191
E R ++ E A+Q +EE L E+ L+L E + ++ + +++
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 192 ERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLRE-EIRLVKQKLFKVT 250
+ ++L E LL E + ++ A L + E E+RL K++ K
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE--KSR 1050
Query: 251 KECVAYQYQLECRQQDV-AQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAP 309
+E + +LE D Q AD + + QL+++ +L+ A + +++ Q+ A
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 310 PSQRD--GHF--LQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQ 365
R+ GH LQE N + ++DL EE E L+ + T TQ
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA-----LKTELEDTLDSTATQ 1165
Query: 366 AEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLR 425
E++ +E + + + L + R+ E Q+ +RQK + V++ EQLE+ + + L
Sbjct: 1166 QELRAKRE--QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 426 NGVQLQQQKNKEME-QLR-LSLAEELSTYKAMLLPKSLEQADAPTS 469
Q +++N ++ +LR L A++ +K L +++ + S
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Score = 48.5 bits (114), Expect = 1e-05
Identities = 77/380 (20%), Positives = 165/380 (43%), Gaps = 68/380 (17%)
Query: 152 EESLRAEQSPSVEENLSIEDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQ 209
+E + A+Q+ +E ++S +++L + + Q V LEE + + E+ +
Sbjct: 1353 DEEMEAKQN--LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--------E 1402
Query: 210 EVQQVHQDILAAY----KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
+ Q +++ AAY K + + E D L ++ +Q + + K+ + L +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 266 DVAQFADFREVLT-------TRATQLS---EELAQLRDAYQKQKEQLRQQLEAPPSQRDG 315
+++AD R+ T+A L+ EE + ++ ++ + L+ ++E S +D
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 316 -----HFLQESRR-LSAQFENLMAESRQDLEEEYEP-----------------QFLRLL- 351
H L++S+R L Q E + + ++LE+E + QF R L
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 352 ---ERKEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
E+ E + LQR + E+++ ++ A ++L ++LE Q + R+
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 405 EEVQQYREQLEEMEERQRQLRNG----------VQLQQQKNKEMEQLRLSLAEELSTYKA 454
E ++Q R+ +M++ QR+L + + ++K K +E + L E+L+ +
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 455 MLLPKSLEQADAPTSQAGGM 474
LE+ + A +
Sbjct: 1702 ARKQADLEKEELAEELASSL 1721
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/140 (29%), Positives = 66/140 (47%), Gaps = 16/140 (11%)
Query: 329 ENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE--IQEMKEALRPLQAEARQLR 386
E M +L++ E Q E KE K Q T+ + +QE +A L AEA ++R
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 387 LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLA 446
++ +A +Q+ +E + + +LEE E+R +QL Q + K+M Q L L
Sbjct: 911 VR-------LAAKKQELEEILHEMEARLEEEEDRGQQL-------QAERKKMAQQMLDLE 956
Query: 447 EELSTYKAMLLPKSLEQADA 466
E+L +A LE+ A
Sbjct: 957 EQLEEEEAARQKLQLEKVTA 976
Score = 35.0 bits (79), Expect = 0.15
Identities = 23/93 (24%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 359 KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQ--KRDEEVQQYREQLEE 416
KA + Q ++ MK R A + Q L ++ + Q +++EE+Q ++L++
Sbjct: 804 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 863
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ERQ++ N ++ +QK+ ++ + + L E+L
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 77.4 bits (189), Expect = 3e-14
Identities = 113/499 (22%), Positives = 214/499 (42%), Gaps = 63/499 (12%)
Query: 16 AARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDL-----DET 70
A + R EA + K + +L+ A AL E L ++ L + + + DL D
Sbjct: 1475 ADERDRAEAEAR-EKETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 71 LYVQETEKAEEAL--YIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF-----VEG 123
V E EK++ AL +EE E L E + + +E + + QF
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 124 PVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL-----LEGR 178
K + ++E ET E+ + +L A +E +L +DLEL ++GR
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDL--KDLELQADSAIKGR 1647
Query: 179 FQQCVQAVAQLEEERDQLIHELVLLREPALQ-----------------EVQQVHQDILAA 221
++ ++ + +L+ + EL R + ++ Q+ +D+ AA
Sbjct: 1648 -EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 222 YKLHAQAELERDGLREEI-------RLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFR 274
+ QA+LE++ L EE+ ++ + ++ + +LE Q ++ +D
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
T +A QLS ELA R QK E RQQLE + + + ++F++ +A
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ + E Q + K+A TK+L++ +++E+ LQ E R + +
Sbjct: 1826 LEAKIAQ-LEEQVEQEAREKQAATKSLKQKDKKLKEIL-----LQVE------DERKMAE 1873
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKA 454
Q +K + V+Q + QLEE EE +++ + Q++ E + ++ E++ K+
Sbjct: 1874 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 455 MLLPKSLEQADAPTSQAGG 473
L + E + P+ ++GG
Sbjct: 1934 K-LRRGNETSFVPSRRSGG 1951
Score = 62.8 bits (151), Expect = 7e-10
Identities = 85/414 (20%), Positives = 187/414 (45%), Gaps = 40/414 (9%)
Query: 38 AEALNPEVTLSSEGSLNLEDILY-----LEDTGDLDETLYVQETEKAEEALYIEEAMQPD 92
AEA V L+++ LE+IL+ LE+ D + L + + A++ L +EE ++ +
Sbjct: 911 AEAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 93 EALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPE 152
EA + + +E+ T +I+ +E + V+ + E+ E
Sbjct: 970 EA--------ARQKLQLEKVTAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLE 1012
Query: 153 ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
E + + EE ++L L+ + + + + ++ ++ EL L+ +
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 213 QVHQDILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
H+ I L AQ AEL+ ++E L + L ++ E L+ ++ +
Sbjct: 1073 DFHEQIA---DLQAQIAELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHF--LQESRRLSAQFE 329
D +E L SE A R+ +KQK L ++LEA ++ + + L A+ E
Sbjct: 1129 DLQEDLD------SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 330 NLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
+ ++ L+EE ++ E ++ +A++ ++++ K A L + L +N
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 390 RNLEDQIALVRQKRDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLR 442
+L ++ ++ Q + +EV+ +++LE +++E Q + +G + + + N ++ +L+
Sbjct: 1241 ADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Score = 58.9 bits (141), Expect = 1e-08
Identities = 77/328 (23%), Positives = 144/328 (43%), Gaps = 47/328 (14%)
Query: 141 ETVTRAEKSNPE-ESLRAEQSPSVEE-NLSIEDLEL---LEGRFQQCVQAVAQLEEERDQ 195
+T R +K+ E + L + S EE NL E L+ L ++ +A ++E ++
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF--KVTKEC 253
++HE+ E L+E + Q + A K AQ L+ + EE +QKL KVT E
Sbjct: 930 ILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 985
Query: 254 VAYQYQLECRQQDVA--QFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPS 311
+ + E D + + R++L R + L+ LA+ + K +L+ + E+ S
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMIS 1044
Query: 312 QRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEM 371
+ + +E + SRQ+LE+ L+RK G + +
Sbjct: 1045 ELEVRLKKEEK------------SRQELEK---------LKRKLEG---------DASDF 1074
Query: 372 KEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYR---EQLEEMEERQRQLRNGV 428
E + LQA+ +L++Q E+++ + D+E+ Q +++ E+E L+ +
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKAML 456
++ + E+ + L EEL K L
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTEL 1162
Score = 57.4 bits (137), Expect = 3e-08
Identities = 78/346 (22%), Positives = 151/346 (43%), Gaps = 26/346 (7%)
Query: 141 ETVTRAEKSNPEESLRAEQSPSVEENLSIED-----LEL----LEGRFQQCVQAVAQLEE 191
E R ++ E A+Q +EE L E+ L+L E + ++ + +++
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 192 ERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLRE-EIRLVKQKLFKVT 250
+ ++L E LL E + ++ A L + E E+RL K++ K
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE--KSR 1057
Query: 251 KECVAYQYQLECRQQDV-AQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAP 309
+E + +LE D Q AD + + QL+++ +L+ A + +++ Q+ A
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 310 PSQRD--GHF--LQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQ 365
R+ GH LQE N + ++DL EE E L+ + T TQ
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA-----LKTELEDTLDSTATQ 1172
Query: 366 AEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLR 425
E++ +E + + + L + R+ E Q+ +RQK + V++ EQLE+ + + L
Sbjct: 1173 QELRAKRE--QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 426 NGVQLQQQKNKEME-QLR-LSLAEELSTYKAMLLPKSLEQADAPTS 469
Q +++N ++ +LR L A++ +K L +++ + S
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Score = 48.5 bits (114), Expect = 1e-05
Identities = 77/380 (20%), Positives = 165/380 (43%), Gaps = 68/380 (17%)
Query: 152 EESLRAEQSPSVEENLSIEDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQ 209
+E + A+Q+ +E ++S +++L + + Q V LEE + + E+ +
Sbjct: 1360 DEEMEAKQN--LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--------E 1409
Query: 210 EVQQVHQDILAAY----KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
+ Q +++ AAY K + + E D L ++ +Q + + K+ + L +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 266 DVAQFADFREVLT-------TRATQLS---EELAQLRDAYQKQKEQLRQQLEAPPSQRDG 315
+++AD R+ T+A L+ EE + ++ ++ + L+ ++E S +D
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 316 -----HFLQESRR-LSAQFENLMAESRQDLEEEYEP-----------------QFLRLL- 351
H L++S+R L Q E + + ++LE+E + QF R L
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 352 ---ERKEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
E+ E + LQR + E+++ ++ A ++L ++LE Q + R+
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 405 EEVQQYREQLEEMEERQRQLRNG----------VQLQQQKNKEMEQLRLSLAEELSTYKA 454
E ++Q R+ +M++ QR+L + + ++K K +E + L E+L+ +
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 455 MLLPKSLEQADAPTSQAGGM 474
LE+ + A +
Sbjct: 1709 ARKQADLEKEELAEELASSL 1728
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/140 (29%), Positives = 66/140 (47%), Gaps = 16/140 (11%)
Query: 329 ENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE--IQEMKEALRPLQAEARQLR 386
E M +L++ E Q E KE K Q T+ + +QE +A L AEA ++R
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 387 LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLA 446
++ +A +Q+ +E + + +LEE E+R +QL Q + K+M Q L L
Sbjct: 918 VR-------LAAKKQELEEILHEMEARLEEEEDRGQQL-------QAERKKMAQQMLDLE 963
Query: 447 EELSTYKAMLLPKSLEQADA 466
E+L +A LE+ A
Sbjct: 964 EQLEEEEAARQKLQLEKVTA 983
Score = 35.0 bits (79), Expect = 0.15
Identities = 23/93 (24%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 359 KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQ--KRDEEVQQYREQLEE 416
KA + Q ++ MK R A + Q L ++ + Q +++EE+Q ++L++
Sbjct: 811 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 870
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ERQ++ N ++ +QK+ ++ + + L E+L
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 74.3 bits (181), Expect = 2e-13
Identities = 109/482 (22%), Positives = 205/482 (42%), Gaps = 62/482 (12%)
Query: 16 AARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDL-----DET 70
A + R EA + K + +L+ A AL E L ++ L + + + DL D
Sbjct: 1475 ADERDRAEAEAR-EKETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 71 LYVQETEKAEEAL--YIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF-----VEG 123
V E EK++ AL +EE E L E + + +E + + QF
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 124 PVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL-----LEGR 178
K + ++E ET E+ + +L A +E +L +DLEL ++GR
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDL--KDLELQADSAIKGR 1647
Query: 179 FQQCVQAVAQLEEERDQLIHELVLLREPALQ-----------------EVQQVHQDILAA 221
++ ++ + +L+ + EL R + ++ Q+ +D+ AA
Sbjct: 1648 -EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 222 YKLHAQAELERDGLREEI-------RLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFR 274
+ QA+LE++ L EE+ ++ + ++ + +LE Q ++ +D
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
T +A QLS ELA R QK E RQQLE + + + ++F++ +A
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ + E Q + K+A TK+L++ +++E+ LQ E R + +
Sbjct: 1826 LEAKIAQ-LEEQVEQEAREKQAATKSLKQKDKKLKEIL-----LQVE------DERKMAE 1873
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKA 454
Q +K + V+Q + QLEE EE +++ + Q++ E + ++ E++ K+
Sbjct: 1874 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 455 ML 456
L
Sbjct: 1934 KL 1935
Score = 62.8 bits (151), Expect = 7e-10
Identities = 85/414 (20%), Positives = 187/414 (45%), Gaps = 40/414 (9%)
Query: 38 AEALNPEVTLSSEGSLNLEDILY-----LEDTGDLDETLYVQETEKAEEALYIEEAMQPD 92
AEA V L+++ LE+IL+ LE+ D + L + + A++ L +EE ++ +
Sbjct: 911 AEAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 93 EALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPE 152
EA + + +E+ T +I+ +E + V+ + E+ E
Sbjct: 970 EA--------ARQKLQLEKVTAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLE 1012
Query: 153 ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
E + + EE ++L L+ + + + + ++ ++ EL L+ +
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 213 QVHQDILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
H+ I L AQ AEL+ ++E L + L ++ E L+ ++ +
Sbjct: 1073 DFHEQIA---DLQAQIAELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHF--LQESRRLSAQFE 329
D +E L SE A R+ +KQK L ++LEA ++ + + L A+ E
Sbjct: 1129 DLQEDLD------SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 330 NLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
+ ++ L+EE ++ E ++ +A++ ++++ K A L + L +N
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 390 RNLEDQIALVRQKRDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLR 442
+L ++ ++ Q + +EV+ +++LE +++E Q + +G + + + N ++ +L+
Sbjct: 1241 ADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Score = 58.9 bits (141), Expect = 1e-08
Identities = 77/328 (23%), Positives = 144/328 (43%), Gaps = 47/328 (14%)
Query: 141 ETVTRAEKSNPE-ESLRAEQSPSVEE-NLSIEDLEL---LEGRFQQCVQAVAQLEEERDQ 195
+T R +K+ E + L + S EE NL E L+ L ++ +A ++E ++
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF--KVTKEC 253
++HE+ E L+E + Q + A K AQ L+ + EE +QKL KVT E
Sbjct: 930 ILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 985
Query: 254 VAYQYQLECRQQDVA--QFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPS 311
+ + E D + + R++L R + L+ LA+ + K +L+ + E+ S
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMIS 1044
Query: 312 QRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEM 371
+ + +E + SRQ+LE+ L+RK G + +
Sbjct: 1045 ELEVRLKKEEK------------SRQELEK---------LKRKLEG---------DASDF 1074
Query: 372 KEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYR---EQLEEMEERQRQLRNGV 428
E + LQA+ +L++Q E+++ + D+E+ Q +++ E+E L+ +
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKAML 456
++ + E+ + L EEL K L
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTEL 1162
Score = 57.4 bits (137), Expect = 3e-08
Identities = 78/346 (22%), Positives = 151/346 (43%), Gaps = 26/346 (7%)
Query: 141 ETVTRAEKSNPEESLRAEQSPSVEENLSIED-----LEL----LEGRFQQCVQAVAQLEE 191
E R ++ E A+Q +EE L E+ L+L E + ++ + +++
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 192 ERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLRE-EIRLVKQKLFKVT 250
+ ++L E LL E + ++ A L + E E+RL K++ K
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE--KSR 1057
Query: 251 KECVAYQYQLECRQQDV-AQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAP 309
+E + +LE D Q AD + + QL+++ +L+ A + +++ Q+ A
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 310 PSQRD--GHF--LQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQ 365
R+ GH LQE N + ++DL EE E L+ + T TQ
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA-----LKTELEDTLDSTATQ 1172
Query: 366 AEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLR 425
E++ +E + + + L + R+ E Q+ +RQK + V++ EQLE+ + + L
Sbjct: 1173 QELRAKRE--QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 426 NGVQLQQQKNKEME-QLR-LSLAEELSTYKAMLLPKSLEQADAPTS 469
Q +++N ++ +LR L A++ +K L +++ + S
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Score = 48.5 bits (114), Expect = 1e-05
Identities = 77/380 (20%), Positives = 165/380 (43%), Gaps = 68/380 (17%)
Query: 152 EESLRAEQSPSVEENLSIEDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQ 209
+E + A+Q+ +E ++S +++L + + Q V LEE + + E+ +
Sbjct: 1360 DEEMEAKQN--LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--------E 1409
Query: 210 EVQQVHQDILAAY----KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
+ Q +++ AAY K + + E D L ++ +Q + + K+ + L +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 266 DVAQFADFREVLT-------TRATQLS---EELAQLRDAYQKQKEQLRQQLEAPPSQRDG 315
+++AD R+ T+A L+ EE + ++ ++ + L+ ++E S +D
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 316 -----HFLQESRR-LSAQFENLMAESRQDLEEEYEP-----------------QFLRLL- 351
H L++S+R L Q E + + ++LE+E + QF R L
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 352 ---ERKEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
E+ E + LQR + E+++ ++ A ++L ++LE Q + R+
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 405 EEVQQYREQLEEMEERQRQLRNG----------VQLQQQKNKEMEQLRLSLAEELSTYKA 454
E ++Q R+ +M++ QR+L + + ++K K +E + L E+L+ +
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 455 MLLPKSLEQADAPTSQAGGM 474
LE+ + A +
Sbjct: 1709 ARKQADLEKEELAEELASSL 1728
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/140 (29%), Positives = 66/140 (47%), Gaps = 16/140 (11%)
Query: 329 ENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE--IQEMKEALRPLQAEARQLR 386
E M +L++ E Q E KE K Q T+ + +QE +A L AEA ++R
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 387 LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLA 446
++ +A +Q+ +E + + +LEE E+R +QL Q + K+M Q L L
Sbjct: 918 VR-------LAAKKQELEEILHEMEARLEEEEDRGQQL-------QAERKKMAQQMLDLE 963
Query: 447 EELSTYKAMLLPKSLEQADA 466
E+L +A LE+ A
Sbjct: 964 EQLEEEEAARQKLQLEKVTA 983
Score = 35.0 bits (79), Expect = 0.15
Identities = 23/93 (24%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 359 KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQ--KRDEEVQQYREQLEE 416
KA + Q ++ MK R A + Q L ++ + Q +++EE+Q ++L++
Sbjct: 811 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 870
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ERQ++ N ++ +QK+ ++ + + L E+L
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 74.3 bits (181), Expect = 2e-13
Identities = 109/482 (22%), Positives = 205/482 (42%), Gaps = 62/482 (12%)
Query: 16 AARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDL-----DET 70
A + R EA + K + +L+ A AL E L ++ L + + + DL D
Sbjct: 1468 ADERDRAEAEAR-EKETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 71 LYVQETEKAEEAL--YIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF-----VEG 123
V E EK++ AL +EE E L E + + +E + + QF
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 124 PVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL-----LEGR 178
K + ++E ET E+ + +L A +E +L +DLEL ++GR
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDL--KDLELQADSAIKGR 1640
Query: 179 FQQCVQAVAQLEEERDQLIHELVLLREPALQ-----------------EVQQVHQDILAA 221
++ ++ + +L+ + EL R + ++ Q+ +D+ AA
Sbjct: 1641 -EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 222 YKLHAQAELERDGLREEI-------RLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFR 274
+ QA+LE++ L EE+ ++ + ++ + +LE Q ++ +D
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
T +A QLS ELA R QK E RQQLE + + + ++F++ +A
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ + E Q + K+A TK+L++ +++E+ LQ E R + +
Sbjct: 1819 LEAKIAQ-LEEQVEQEAREKQAATKSLKQKDKKLKEIL-----LQVE------DERKMAE 1866
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKA 454
Q +K + V+Q + QLEE EE +++ + Q++ E + ++ E++ K+
Sbjct: 1867 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 455 ML 456
L
Sbjct: 1927 KL 1928
Score = 62.8 bits (151), Expect = 7e-10
Identities = 85/414 (20%), Positives = 187/414 (45%), Gaps = 40/414 (9%)
Query: 38 AEALNPEVTLSSEGSLNLEDILY-----LEDTGDLDETLYVQETEKAEEALYIEEAMQPD 92
AEA V L+++ LE+IL+ LE+ D + L + + A++ L +EE ++ +
Sbjct: 904 AEAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 93 EALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPE 152
EA + + +E+ T +I+ +E + V+ + E+ E
Sbjct: 963 EA--------ARQKLQLEKVTAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLE 1005
Query: 153 ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
E + + EE ++L L+ + + + + ++ ++ EL L+ +
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 213 QVHQDILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
H+ I L AQ AEL+ ++E L + L ++ E L+ ++ +
Sbjct: 1066 DFHEQIA---DLQAQIAELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHF--LQESRRLSAQFE 329
D +E L SE A R+ +KQK L ++LEA ++ + + L A+ E
Sbjct: 1122 DLQEDLD------SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 330 NLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
+ ++ L+EE ++ E ++ +A++ ++++ K A L + L +N
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 390 RNLEDQIALVRQKRDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLR 442
+L ++ ++ Q + +EV+ +++LE +++E Q + +G + + + N ++ +L+
Sbjct: 1234 ADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Score = 58.9 bits (141), Expect = 1e-08
Identities = 77/328 (23%), Positives = 144/328 (43%), Gaps = 47/328 (14%)
Query: 141 ETVTRAEKSNPE-ESLRAEQSPSVEE-NLSIEDLEL---LEGRFQQCVQAVAQLEEERDQ 195
+T R +K+ E + L + S EE NL E L+ L ++ +A ++E ++
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF--KVTKEC 253
++HE+ E L+E + Q + A K AQ L+ + EE +QKL KVT E
Sbjct: 923 ILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 978
Query: 254 VAYQYQLECRQQDVA--QFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPS 311
+ + E D + + R++L R + L+ LA+ + K +L+ + E+ S
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMIS 1037
Query: 312 QRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEM 371
+ + +E + SRQ+LE+ L+RK G + +
Sbjct: 1038 ELEVRLKKEEK------------SRQELEK---------LKRKLEG---------DASDF 1067
Query: 372 KEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYR---EQLEEMEERQRQLRNGV 428
E + LQA+ +L++Q E+++ + D+E+ Q +++ E+E L+ +
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKAML 456
++ + E+ + L EEL K L
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTEL 1155
Score = 57.4 bits (137), Expect = 3e-08
Identities = 78/346 (22%), Positives = 151/346 (43%), Gaps = 26/346 (7%)
Query: 141 ETVTRAEKSNPEESLRAEQSPSVEENLSIED-----LEL----LEGRFQQCVQAVAQLEE 191
E R ++ E A+Q +EE L E+ L+L E + ++ + +++
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 192 ERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLRE-EIRLVKQKLFKVT 250
+ ++L E LL E + ++ A L + E E+RL K++ K
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE--KSR 1050
Query: 251 KECVAYQYQLECRQQDV-AQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAP 309
+E + +LE D Q AD + + QL+++ +L+ A + +++ Q+ A
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 310 PSQRD--GHF--LQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQ 365
R+ GH LQE N + ++DL EE E L+ + T TQ
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA-----LKTELEDTLDSTATQ 1165
Query: 366 AEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLR 425
E++ +E + + + L + R+ E Q+ +RQK + V++ EQLE+ + + L
Sbjct: 1166 QELRAKRE--QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 426 NGVQLQQQKNKEME-QLR-LSLAEELSTYKAMLLPKSLEQADAPTS 469
Q +++N ++ +LR L A++ +K L +++ + S
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Score = 48.5 bits (114), Expect = 1e-05
Identities = 77/380 (20%), Positives = 165/380 (43%), Gaps = 68/380 (17%)
Query: 152 EESLRAEQSPSVEENLSIEDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQ 209
+E + A+Q+ +E ++S +++L + + Q V LEE + + E+ +
Sbjct: 1353 DEEMEAKQN--LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--------E 1402
Query: 210 EVQQVHQDILAAY----KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
+ Q +++ AAY K + + E D L ++ +Q + + K+ + L +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 266 DVAQFADFREVLT-------TRATQLS---EELAQLRDAYQKQKEQLRQQLEAPPSQRDG 315
+++AD R+ T+A L+ EE + ++ ++ + L+ ++E S +D
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 316 -----HFLQESRR-LSAQFENLMAESRQDLEEEYEP-----------------QFLRLL- 351
H L++S+R L Q E + + ++LE+E + QF R L
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 352 ---ERKEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
E+ E + LQR + E+++ ++ A ++L ++LE Q + R+
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 405 EEVQQYREQLEEMEERQRQLRNG----------VQLQQQKNKEMEQLRLSLAEELSTYKA 454
E ++Q R+ +M++ QR+L + + ++K K +E + L E+L+ +
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 455 MLLPKSLEQADAPTSQAGGM 474
LE+ + A +
Sbjct: 1702 ARKQADLEKEELAEELASSL 1721
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/140 (29%), Positives = 66/140 (47%), Gaps = 16/140 (11%)
Query: 329 ENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE--IQEMKEALRPLQAEARQLR 386
E M +L++ E Q E KE K Q T+ + +QE +A L AEA ++R
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 387 LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLA 446
++ +A +Q+ +E + + +LEE E+R +QL Q + K+M Q L L
Sbjct: 911 VR-------LAAKKQELEEILHEMEARLEEEEDRGQQL-------QAERKKMAQQMLDLE 956
Query: 447 EELSTYKAMLLPKSLEQADA 466
E+L +A LE+ A
Sbjct: 957 EQLEEEEAARQKLQLEKVTA 976
Score = 35.0 bits (79), Expect = 0.15
Identities = 23/93 (24%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 359 KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQ--KRDEEVQQYREQLEE 416
KA + Q ++ MK R A + Q L ++ + Q +++EE+Q ++L++
Sbjct: 804 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 863
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ERQ++ N ++ +QK+ ++ + + L E+L
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
>gi|131412225 keratin 13 isoform a [Homo sapiens]
Length = 458
Score = 73.9 bits (180), Expect = 3e-13
Identities = 73/344 (21%), Positives = 152/344 (44%), Gaps = 47/344 (13%)
Query: 165 ENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQE---------VQQVH 215
E +++++L + + V+A+ + + + I + L + PA E ++++
Sbjct: 104 EKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELR 163
Query: 216 QDILAAYKLHAQAELERDGLR---EEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFAD 272
IL A + + LE D R ++ RL Y+ +L RQ A
Sbjct: 164 DKILTATIENNRVILEIDNARLAADDFRL-------------KYENELALRQSVEADING 210
Query: 273 FREVLTT----------RATQLSEELAQLRDAYQKQKEQLRQQ--------LEAPPSQRD 314
R VL + L+EELA ++ ++++ ++ Q ++A P
Sbjct: 211 LRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDL 270
Query: 315 GHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
L E R Q+E + +R+D EE + + L + T +Q ++ EI E++
Sbjct: 271 TRVLAEMRE---QYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRT 327
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
L+ L+ E + LE+ +A + ++QQ + + +E + +LR+ ++ Q Q+
Sbjct: 328 LQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQE 387
Query: 435 NKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMETQS 478
K + ++ L +E++TY+++L + + P+S AG + +S
Sbjct: 388 YKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSS-AGSVSPRS 430
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 73.6 bits (179), Expect = 4e-13
Identities = 70/306 (22%), Positives = 138/306 (45%), Gaps = 22/306 (7%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREP--ALQEVQQVHQ----------D 217
E ++ L +F + V LE++ L + LL++ A + + + +
Sbjct: 93 EQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLE 152
Query: 218 ILAAYKLHAQAEL-ERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV 276
L KL +AEL GL E+ K K + + + ++DV + +
Sbjct: 153 TLGQEKLKLEAELGNMQGLVEDF---KNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVE 209
Query: 277 LTTRATQLSEELAQLRDAYQKQKEQLRQQLE------APPSQRDGHFLQESRRLSAQFEN 330
L +R L++E+ LR Y+++ +L+ Q+ + + R + AQ+E+
Sbjct: 210 LESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYED 269
Query: 331 LMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNR 390
+ SR + E Y+ ++ L L+RT+ EI EM + LQAE L+ Q
Sbjct: 270 IANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRA 329
Query: 391 NLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
+LE IA Q+ + ++ +L E+E ++ + + Q ++ +E+ ++L+L E++
Sbjct: 330 SLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIA 389
Query: 451 TYKAML 456
TY+ +L
Sbjct: 390 TYRKLL 395
>gi|14917115 keratin 31 [Homo sapiens]
Length = 416
Score = 73.6 bits (179), Expect = 4e-13
Identities = 70/316 (22%), Positives = 142/316 (44%), Gaps = 42/316 (13%)
Query: 170 EDLELLEGRFQQCVQAVAQLEE---ERDQLIHELVLLREPAL--------QEVQQVHQDI 218
E ++ L R ++ V QLE E + LI E +EP L + ++++ Q I
Sbjct: 58 ETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKI 117
Query: 219 LAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLT 278
L +A+ ++ D + + K YQ +L RQ + R +L
Sbjct: 118 LCTKSENARLVVQIDNAKLAADDFRTK----------YQTELSLRQLVESDINGLRRILD 167
Query: 279 ----------TRATQLSEELAQLRDAYQKQKEQLRQQL--------EAPPSQRDGHFLQE 320
+ L EEL L+ ++++ LR QL +A P+ L E
Sbjct: 168 ELTLCKSDLEAQVESLKEELLCLKSNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNRVLNE 227
Query: 321 SRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQA 380
+R +Q+E L+ +R+++E+ + Q L ++ + ++ LQ QAEI E++ + L+
Sbjct: 228 TR---SQYEALVETNRREVEQWFTTQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEI 284
Query: 381 EARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQ 440
E + +LE+ + + ++ Q + + +E + ++R+ ++ Q Q+ + +
Sbjct: 285 ELQAQHNLRDSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLD 344
Query: 441 LRLSLAEELSTYKAML 456
+R L E++TY+++L
Sbjct: 345 VRARLECEINTYRSLL 360
>gi|10337581 type I hair keratin 3B [Homo sapiens]
Length = 404
Score = 73.2 bits (178), Expect = 5e-13
Identities = 67/325 (20%), Positives = 145/325 (44%), Gaps = 22/325 (6%)
Query: 170 EDLELLEGRFQQCVQAVAQLEE---ERDQLIHELVLLREPAL--------QEVQQVHQDI 218
E ++ L R ++ V QLE E + LI E +EP L + ++++ Q I
Sbjct: 58 ETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKI 117
Query: 219 LAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLT 278
L + +A+ ++ D + + K + + ++ + + R L
Sbjct: 118 LCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCRSDLE 177
Query: 279 TRATQLSEELAQLRDAYQKQKEQLRQQL--------EAPPSQRDGHFLQESRRLSAQFEN 330
+ L EEL L+ ++++ LR QL +A P+ L E+R Q+E
Sbjct: 178 AQMESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNETRN---QYEA 234
Query: 331 LMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNR 390
L+ +R+++E+ + Q L ++ + ++ LQ QAEI E++ + L+ E +
Sbjct: 235 LVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLRY 294
Query: 391 NLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
+LE+ + + ++ Q + + +E + ++R+ ++ Q Q+ + + +R L E++
Sbjct: 295 SLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEIN 354
Query: 451 TYKAMLLPKSLEQADAPTSQAGGME 475
TY+++L + + P + E
Sbjct: 355 TYRSLLESEDCKLPSNPCATTNACE 379
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 73.2 bits (178), Expect = 5e-13
Identities = 67/305 (21%), Positives = 140/305 (45%), Gaps = 18/305 (5%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAE 229
E ++ L +F + V LE++ L + LL+E + V+Q + + +Y + +
Sbjct: 151 EQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQ 210
Query: 230 LE-----RDGLREEIRLVKQKL--FKVTKEC-----VAYQYQLECRQQDVAQFADFREVL 277
LE R L E+R ++ + FKV E A + + ++DV + L
Sbjct: 211 LESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVEL 270
Query: 278 TTRATQLSEELAQLRDAYQKQKEQLRQQLE------APPSQRDGHFLQESRRLSAQFENL 331
+ L EE+ + + + QL+ Q+ + + R+ + AQ+E++
Sbjct: 271 EAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQYEDI 330
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRN 391
SR + E Y+ ++ L L+ T+ EI EM ++ L+AE ++ Q +
Sbjct: 331 ANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSS 390
Query: 392 LEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELST 451
L+ IA Q+ + ++ R +L ++EE ++ + + ++ +E+ ++L+L E++T
Sbjct: 391 LQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIAT 450
Query: 452 YKAML 456
Y+ +L
Sbjct: 451 YRKLL 455
>gi|28173564 keratin 73 [Homo sapiens]
Length = 540
Score = 72.4 bits (176), Expect = 9e-13
Identities = 71/309 (22%), Positives = 138/309 (44%), Gaps = 26/309 (8%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAE 229
E +++L +F + V LE++ L + LL++ L + + IL Y + + +
Sbjct: 134 EQIKVLNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQ 193
Query: 230 LE-----RDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQL 284
LE R L E+R V++ + K Y+ ++ R +F ++ + T
Sbjct: 194 LETLSGDRVRLDSELRSVREVVEDYKKR---YEEEINKRTTAENEFVVLKKDVDAAYTSK 250
Query: 285 SEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLS-----------------AQ 327
E A++ DA + + + E +Q H S LS AQ
Sbjct: 251 VELQAKV-DALDGEIKFFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLDSIIAEVRAQ 309
Query: 328 FENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRL 387
+E + +S+ + E Y+ +F L L+ T+ EI E+ ++ L++E ++
Sbjct: 310 YEEIARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRLRSEIESVKK 369
Query: 388 QNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAE 447
Q NLE IA Q+ D ++ R +L+E+E +Q + + ++ +E+ ++LSL
Sbjct: 370 QCANLETAIADAEQRGDCALKDARAKLDELEGALQQAKEELARMLREYQELLSVKLSLDI 429
Query: 448 ELSTYKAML 456
E++TY+ +L
Sbjct: 430 EIATYRKLL 438
>gi|131412228 keratin 13 isoform b [Homo sapiens]
Length = 420
Score = 72.0 bits (175), Expect = 1e-12
Identities = 69/333 (20%), Positives = 146/333 (43%), Gaps = 46/333 (13%)
Query: 165 ENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQE---------VQQVH 215
E +++++L + + V+A+ + + + I + L + PA E ++++
Sbjct: 104 EKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELR 163
Query: 216 QDILAAYKLHAQAELERDGLR---EEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFAD 272
IL A + + LE D R ++ RL Y+ +L RQ A
Sbjct: 164 DKILTATIENNRVILEIDNARLAADDFRL-------------KYENELALRQSVEADING 210
Query: 273 FREVLTT----------RATQLSEELAQLRDAYQKQKEQLRQQ--------LEAPPSQRD 314
R VL + L+EELA ++ ++++ ++ Q ++A P
Sbjct: 211 LRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDL 270
Query: 315 GHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
L E R Q+E + +R+D EE + + L + T +Q ++ EI E++
Sbjct: 271 TRVLAEMRE---QYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRT 327
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
L+ L+ E + LE+ +A + ++QQ + + +E + +LR+ ++ Q Q+
Sbjct: 328 LQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQE 387
Query: 435 NKEMEQLRLSLAEELSTYKAMLLPKSLEQADAP 467
K + ++ L +E++TY+++L + ++ P
Sbjct: 388 YKMLLDIKTRLEQEIATYRSLLEGQDAKKRQPP 420
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 71.6 bits (174), Expect = 1e-12
Identities = 81/352 (23%), Positives = 151/352 (42%), Gaps = 29/352 (8%)
Query: 127 PGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAV 186
PG P P + E VT + +L+ + S E ++ L +F + V
Sbjct: 130 PGFPVCPPGGIQE---VTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKV 186
Query: 187 AQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAEL-----ERDGLREEIRL 241
LE++ L + LL+E + V+Q + + Y + + +L ER L E+R
Sbjct: 187 RFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRN 246
Query: 242 VKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQ 301
+ Q L + K Y+ ++ R +F ++ + A EL DA +
Sbjct: 247 M-QDLVEDFKN--KYEDEINKRTTAENEFVMLKKDVDA-AYMNKVELEAKVDALMDEINF 302
Query: 302 LRQQLEAPPSQRDGHFLQESRRLS-----------------AQFENLMAESRQDLEEEYE 344
++ +A SQ H S LS AQ+E + SR + E Y+
Sbjct: 303 MKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQ 362
Query: 345 PQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
++ L + L+ T+ EI EM ++ L+AE ++ Q NL++ IA Q+ +
Sbjct: 363 TKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGE 422
Query: 405 EEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAML 456
++ R +L E+EE ++ + + ++ +E+ +L+L E++TY+ +L
Sbjct: 423 LALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLL 474
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 71.2 bits (173), Expect = 2e-12
Identities = 94/376 (25%), Positives = 159/376 (42%), Gaps = 23/376 (6%)
Query: 119 QFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL---L 175
Q + E + +E E EK E S ++ E+L E +EL L
Sbjct: 832 QLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRL 891
Query: 176 EGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGL 235
+ + + AQ EEER Q L ++ +E + + +L K A A + + L
Sbjct: 892 KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERL 951
Query: 236 REEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAY 295
R+++++ K K + T Q QL+ Q+++ + A + S L Q +
Sbjct: 952 RQDMKVQKLKEQETTG---ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL 1008
Query: 296 QKQKEQLRQQLEAPP-SQR-DGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLER 353
QKQ E L+ QL A SQR +QE R + ++ + E LE E L L+E
Sbjct: 1009 QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKE----LEREKASLTLSLME- 1063
Query: 354 KEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQ 409
KE LQ Q E+ +++ ++ Q E ++L Q L + V++K + + Q
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE---VKEKEADFLAQ 1120
Query: 410 YREQLEEMEER---QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADA 466
+ LEE+E ++QLR + Q+ K +++ S +L A P + QA A
Sbjct: 1121 EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQA 1180
Query: 467 PTSQAGGMETQSQGAV 482
+ Q+ G+V
Sbjct: 1181 QLASLYSALQQALGSV 1196
Score = 60.5 bits (145), Expect = 3e-09
Identities = 87/320 (27%), Positives = 144/320 (45%), Gaps = 25/320 (7%)
Query: 134 EHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIED--LELLEGRFQQCVQAVAQLEE 191
E VV + + E+ +E Q + L+ D LE L+ QQ +++E
Sbjct: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
Query: 192 ERDQLIHELVLLREPALQEVQQVHQDILAAYKLHA---QAELERDGLREEIRLVKQKLFK 248
+ D L L E A +++ H + L +K A + EL +G R ++ +++ L
Sbjct: 1839 KADALQGAL----EQAHMTLKERHGE-LQDHKEQARRLEEELAVEGRR--VQALEEVLGD 1891
Query: 249 VTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEA 308
+ E + L QQ A+ A EV TRA Q S AQ A K+++Q + L A
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHEV-ETRALQDSWLQAQ---AVLKERDQELEALRA 1947
Query: 309 PPSQRDGHFLQESRRLSAQFENLMAESRQDLE--EEYEPQFLRLLERKEAGTKALQRT-- 364
SQ H + +R + + + ++ L+ E++ + L EA T LQ +
Sbjct: 1948 E-SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD 2006
Query: 365 --QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEV--QQYREQLEEMEER 420
QA ++++EALR + E + L+ + Q+ +RDEE+ QQ REQL E
Sbjct: 2007 ACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLA 2066
Query: 421 QRQLRNGVQLQQQKNKEMEQ 440
QR N +Q +Q +E E+
Sbjct: 2067 QRVQENMIQEKQNLGQEREE 2086
Score = 58.2 bits (139), Expect = 2e-08
Identities = 74/288 (25%), Positives = 136/288 (47%), Gaps = 46/288 (15%)
Query: 220 AAYKLHA---QAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV 276
A +KLH + + RD LR++++ ++++L E +L+ Q+ ++Q + +
Sbjct: 1244 ALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSK 1303
Query: 277 LTTRATQLSEELAQLRDAYQKQKEQLRQ-QLEAPPSQRDGHFLQESRR-LSAQFENLMA- 333
+ L EL +L + + +LR+ +L+ +Q + LQ ++ L+AQ E+L A
Sbjct: 1304 WEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
Query: 334 --ESR----------QDLE----------EEYEPQFLRLLERKEAGT------KALQ--- 362
E+R +DL EE E + R +E G KALQ
Sbjct: 1364 VVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENL 1423
Query: 363 ----RTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEME 418
+T AE +E E LR E + R + + ++L +KR++EV +EQ++E+E
Sbjct: 1424 ALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELE 1483
Query: 419 ERQRQLRN---GVQLQQQK-NKEMEQLRLSLAEELSTYKAMLLPKSLE 462
+ + L + VQ ++QK + EQ+R L ++ T + +L + LE
Sbjct: 1484 KCRSVLEHLPMAVQEREQKLTVQREQIR-ELEKDRETQRNVLEHQLLE 1530
Score = 57.0 bits (136), Expect = 4e-08
Identities = 102/429 (23%), Positives = 186/429 (43%), Gaps = 59/429 (13%)
Query: 71 LYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKP 130
L V+E E+ +E L EA Q + E + + E E + EG + +
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESL---------SELITLREALESSHL---EGELLRQEQ 563
Query: 131 TSPEHVVYEGETVTRAEKSNPEESLRAEQSP---------SVEENLSIEDLEL------L 175
T + E + AE S+ E +L+ E + ++ E L+++ + L L
Sbjct: 564 TEVTAALARAEQ-SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL 622
Query: 176 EGRFQQCVQAVAQLEEERDQLIHELVLL--REPALQEVQQVHQDILAAYKLHAQAELERD 233
E Q + E+ R+ L +L R AL E + H + A AEL+ D
Sbjct: 623 EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE-KNTHLEAQLQKAEEAGAELQAD 681
Query: 234 --GLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQL 291
++EE +++KL + + A QLE Q+ + +E + RA Q E L +
Sbjct: 682 LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR----QEEVLARAVQEKEALVRE 737
Query: 292 R-------DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYE 344
+ A ++ ++ L +QL+ S ++ L ES AQ +N + E + + E
Sbjct: 738 KAALEVRLQAVERDRQDLAEQLQGLSSAKE---LLESSLFEAQQQNSVIEVTKG---QLE 791
Query: 345 PQFLRLLERKEAGTKALQRTQAEIQ-EMKEALRPLQAEARQLRLQNRNLEDQIALVRQK- 402
Q + + KE ++ + E+ E +A + A ARQL + E + AL +QK
Sbjct: 792 VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ--EGKTALEQQKA 849
Query: 403 -RDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKS 460
++EV Q RE+ E E Q++L ++ +++ E+E + L E+ + +A+ +
Sbjct: 850 AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELE---MRLKEQQTEMEAIQAQRE 906
Query: 461 LEQADAPTS 469
E+ A ++
Sbjct: 907 EERTQAESA 915
Score = 56.2 bits (134), Expect = 6e-08
Identities = 98/475 (20%), Positives = 187/475 (39%), Gaps = 53/475 (11%)
Query: 22 VEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLE------DILYLEDTGDLDETLYVQE 75
V A S P SG ++ E + L+ L E +++ L+ GDL++
Sbjct: 225 VGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDR 284
Query: 76 TEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEH 135
+ L + D ++ ETV E E + + +E + E
Sbjct: 285 VTELSALLTQSQKQNEDYEKMIKAL---RETV---EILETNHTELMEHEASLSRNAQEEK 338
Query: 136 VVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQ 195
+ + + + + EE Q E +L ++ + +Q +A+
Sbjct: 339 LSLQ-QVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALT-------- 389
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVA 255
L+ ++ R A+Q+++Q A L Q + D EE + ++Q+L K+T E
Sbjct: 390 LVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ---QHDQWEEEGKALRQRLQKLTGERDT 446
Query: 256 YQYQLECRQQDVAQFADFREVLTTRATQLSEELAQL-RDAYQKQKEQLRQQLEAPPSQRD 314
Q Q +V + RE+L +L ++L L ++A++ ++ + QL+ +Q
Sbjct: 447 LAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQ 506
Query: 315 GHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEA-----------------G 357
QE L+ + + E LE + L+ +EA
Sbjct: 507 KEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEV 566
Query: 358 TKALQRTQAEIQEMKEALRPLQAEARQLR---LQNRNLEDQIALVRQKRDEEVQQYREQL 414
T AL R + I E+ + L+ E LR ++ L + +AL + ++++ Q E+
Sbjct: 567 TAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEEN 626
Query: 415 EEM---EERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADA 466
+ + E Q RN +Q+ E E+ R +L E+ + +A L + E+A A
Sbjct: 627 QSVCSRMEAAEQARNALQVDL---AEAEKRREALWEKNTHLEAQL--QKAEEAGA 676
Score = 55.1 bits (131), Expect = 1e-07
Identities = 76/313 (24%), Positives = 147/313 (46%), Gaps = 55/313 (17%)
Query: 147 EKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREP 206
+K N E L+ EQ +E+ S+ LE L Q+ Q +L +R+Q+ RE
Sbjct: 1466 KKRNQEVDLQQEQIQELEKCRSV--LEHLPMAVQEREQ---KLTVQREQI-------RE- 1512
Query: 207 ALQEVQQVHQDILAAYKLHAQAELER-----DGLREEIRLVKQKLFKVTKECVAYQ---- 257
L++ ++ +++L H ELE+ + R +++ +K++L VT EC+A +
Sbjct: 1513 -LEKDRETQRNVLE----HQLLELEKKDQMIESQRGQVQDLKKQL--VTLECLALELEEN 1565
Query: 258 -YQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGH 316
+++EC+Q+ + + RE T L+ +L + Q Q Q+ + H
Sbjct: 1566 HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL--------ESH 1617
Query: 317 FLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALR 376
+R L + + + ++ R+ +EE L +KE T+ L+R E+ KE ++
Sbjct: 1618 STVLARELQERDQEVKSQ-REQIEE--------LQRQKEHLTQDLERRDQELMLQKERIQ 1668
Query: 377 PLQAE-ARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKN 435
L+ + RQ ++ +LE QI L ++R E+ R+ M+ER + G + +
Sbjct: 1669 VLEDQRTRQTKILEEDLE-QIKLSLRERGRELTTQRQL---MQERAEE---GKGPSKAQR 1721
Query: 436 KEMEQLRLSLAEE 448
+E ++L L ++
Sbjct: 1722 GSLEHMKLILRDK 1734
Score = 53.9 bits (128), Expect = 3e-07
Identities = 68/297 (22%), Positives = 134/297 (45%), Gaps = 37/297 (12%)
Query: 175 LEGRFQQCVQAVAQLE-------EERDQLIHELVLLR---EPALQEVQQVHQDILAAYKL 224
LE + Q+ +A A+L+ EE++++ +L R E A +++Q+HQ+ ++
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723
Query: 225 HAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQL-------ECRQQDVAQFADFREVL 277
A+A E++ L E ++ +L V ++ QL E + + + V+
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 278 TTRATQLSEEL---AQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLS-AQFENLMA 333
QL ++ Q ++ Q + L+ +L+ SQ + +R+L+ A+ E A
Sbjct: 784 EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
Query: 334 ESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLE 393
+Q E E LR KE QE+ +AL L+ E +L ++ + +
Sbjct: 844 LEQQKAAHEKEVNQLREKWEKERSWHQ--------QELAKALESLEREKMELEMRLKEQQ 895
Query: 394 DQIALVRQKRDEEVQQYRE-----QLEEMEERQRQLRNGVQLQQQ---KNKEMEQLR 442
++ ++ +R+EE Q QLE +ER L +Q Q++ ++++E+LR
Sbjct: 896 TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLR 952
Score = 52.4 bits (124), Expect = 9e-07
Identities = 107/517 (20%), Positives = 197/517 (38%), Gaps = 79/517 (15%)
Query: 12 GAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDETL 71
GA + A T E + L + +A L E+ + LE++L GDL
Sbjct: 1845 GALEQAHMTLKERHGELQDHK---EQARRLEEELAVEGRRVQALEEVL-----GDLRAES 1896
Query: 72 YVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPT 131
+E EKA AL + A Q E H E +++ + +R Q +E + +
Sbjct: 1897 --REQEKALLALQQQCAEQAQE--HEVETRALQDSWLQAQAVLKERDQELEALRAESQSS 1952
Query: 132 SPEHVVYEGETVTRAEKSNPEESL-RAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLE 190
+ E RA +E+L +A + +E +E EL A L+
Sbjct: 1953 RHQ------EEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD 2006
Query: 191 --EERDQLIHELVLLREPALQEVQQVHQ-DILAAYKLHAQAELERDGLREEIRLVKQKLF 247
+ + + E + ++E +Q+ +Q D+ + AQ + E +E +L+++ L
Sbjct: 2007 ACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLA 2066
Query: 248 KVTKECVAYQYQ---LECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQK-EQLR 303
+ +E + + Q E ++++ L Q +E+ +LR+ Q+ E L
Sbjct: 2067 QRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALP 2126
Query: 304 QQLEAPPSQRDGHFLQESR-RLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQ 362
+ P + L RL + E L A RQ E E + E+ + +L
Sbjct: 2127 HSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWR-----EKAQDLALSLA 2181
Query: 363 RTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDE----------------- 405
+T+A + ++E LQA + + + L+D++ L R+ ++
Sbjct: 2182 QTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSR 2241
Query: 406 ----------------------EVQQYREQLEEME--------ERQRQLRNGVQLQQQKN 435
E Q +R++LE ++ +R R R+ VQL+
Sbjct: 2242 GEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLE 2301
Query: 436 KEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAG 472
+ + R E + +A L S A +PT Q G
Sbjct: 2302 QVERERRKLKREAMRAAQAGSLEISKATASSPTQQDG 2338
Score = 52.0 bits (123), Expect = 1e-06
Identities = 84/434 (19%), Positives = 175/434 (40%), Gaps = 64/434 (14%)
Query: 66 DLDETLYVQETEKAEEALYIEEAMQPDEALHV---EEPGNPEETVC-VEETTEPDRIQFV 121
+L + L E EK E + ++E EA+ EE E +C ++ TE +R+ +
Sbjct: 872 ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLL 931
Query: 122 EGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQ 181
E ++ K + + + R + + L+ +++ + + E L+ +Q
Sbjct: 932 ETLLQTQKELADA-----SQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986
Query: 182 CVQAVAQLEEERDQLIHELVLLREPAL-----------------QEVQQVHQDILAAYKL 224
+A L+EE L+ + + L++ QEVQ+ ++ ++
Sbjct: 987 HRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRI 1046
Query: 225 HAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQL 284
+ E E+ L + +Q+L + + Q +L +QD+ + ++ L+ + L
Sbjct: 1047 QKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELL 1106
Query: 285 SEELAQLRDAYQKQKEQLRQQLEA----PPSQRDGHFLQES---------RRLSAQFENL 331
+E+ + + Q+ QL ++LEA R + QE+ R +Q E L
Sbjct: 1107 RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA------LRPLQAEARQL 385
AE + + + + Q L + ++ ++ E+ ++ L P Q AR L
Sbjct: 1167 AAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL 1226
Query: 386 RLQN---------------RNLEDQIALVRQKRD---EEVQQYREQLEEMEERQRQLRNG 427
+ L + +Q RD ++VQ+ E+L + E + Q+
Sbjct: 1227 FKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE 1286
Query: 428 VQ-LQQQKNKEMEQ 440
+Q LQ+Q ++ E+
Sbjct: 1287 LQDLQRQLSQNQEE 1300
Score = 51.2 bits (121), Expect = 2e-06
Identities = 65/319 (20%), Positives = 144/319 (45%), Gaps = 28/319 (8%)
Query: 148 KSNPEESLRAEQSPSVEENLSIEDLEL--LEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
K+ + +Q +EE L+ + E + Q + ++Q +EE+ + + L
Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLES 1313
Query: 206 PALQEVQQVHQDILAAYKLHAQAELER---DGLREEIRLVKQKLFKVTKECVAYQYQLEC 262
E+ ++H+ + + +AEL+R G RE ++ K+ L + A +E
Sbjct: 1314 ----ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAV--VEA 1367
Query: 263 RQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESR 322
R Q A A L E+L R A + + E++ + E + ++ L+ ++
Sbjct: 1368 RAQASA------------AGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
Query: 323 RLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEA 382
+ Q ENL ++ E E E + LR ++ + +Q+ E+ + R + +
Sbjct: 1416 GKALQ-ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDL 1474
Query: 383 RQLRLQN----RNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEM 438
+Q ++Q R++ + + + Q+R++++ REQ+ E+E+ + RN ++ Q + ++
Sbjct: 1475 QQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK 1534
Query: 439 EQLRLSLAEELSTYKAMLL 457
+Q+ S ++ K L+
Sbjct: 1535 DQMIESQRGQVQDLKKQLV 1553
Score = 49.3 bits (116), Expect = 8e-06
Identities = 77/358 (21%), Positives = 141/358 (39%), Gaps = 73/358 (20%)
Query: 145 RAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLR 204
R + N E L+ + + +E E+L L ++ + + LE ++ + + EL+ LR
Sbjct: 488 RLRRVNVELQLQGDSAQGQKEEQQ-EELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546
Query: 205 EPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQ 264
E A H + EL LR+E V L + +
Sbjct: 547 E--------------ALESSHLEGEL----LRQEQTEVTAALARA--------------E 574
Query: 265 QDVAQFADFREVLTTRATQL---SEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQES 321
Q +A+ + L T L + +L+ L +A K L QQL
Sbjct: 575 QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL--------------- 619
Query: 322 RRLSAQFENLMAESRQDLEEE----YEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRP 377
L + EN SR + E+ + +R+EA + +A++Q+ +EA
Sbjct: 620 --LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE 677
Query: 378 LQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKE 437
LQA+ R ++ + ++ +++ R +++ Q + +E + ++ L VQ ++ +E
Sbjct: 678 LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVRE 737
Query: 438 ----------MEQLRLSLAEELSTYKAM--LLPKSLEQADAPTS----QAGGMETQSQ 479
+E+ R LAE+L + LL SL +A S G +E Q Q
Sbjct: 738 KAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQ 795
Score = 48.5 bits (114), Expect = 1e-05
Identities = 77/360 (21%), Positives = 164/360 (45%), Gaps = 44/360 (12%)
Query: 129 KPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIE--DLELLEGRFQ-QCVQA 185
K + V E + + +K ES R + ++ +++E LEL E + +C Q
Sbjct: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQK 1574
Query: 186 V-----AQLEEERDQLIHELVLLREPALQEVQ----QVHQDILAAYKLHAQAELERDGLR 236
+ Q E +R L H L L E QE+Q Q+H D+ + + A+ ERD
Sbjct: 1575 LIKELEGQRETQRVALTH-LTLDLEERSQELQAQSSQIH-DLESHSTVLARELQERD--- 1629
Query: 237 EEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQ----LSEELAQLR 292
+E++ ++++ ++ ++ LE R Q++ + +VL + T+ L E+L Q++
Sbjct: 1630 QEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK 1689
Query: 293 DAYQKQKEQLRQQLEAPPSQ-RDGHFLQESRRLSAQFENLMAESRQ---DLEEEYEPQFL 348
+ +++ +L Q + + +G +++R S + L+ ++ + ++E+ +
Sbjct: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749
Query: 349 RLLERKEAGTKALQRTQAE----IQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
L ++ E + L R E + + ++ + LQ + ++ R Q E + +
Sbjct: 1750 ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
Query: 405 EEVQQYREQLEEMEERQRQLRNGVQLQQQKNKE--------MEQLRLSLAE---ELSTYK 453
+ Q ++LE +++ Q+Q Q Q+++ KE +EQ ++L E EL +K
Sbjct: 1810 RALAQRDQELEALQQEQQQ----AQGQEERVKEKADALQGALEQAHMTLKERHGELQDHK 1865
Score = 36.6 bits (83), Expect = 0.052
Identities = 54/226 (23%), Positives = 91/226 (40%), Gaps = 29/226 (12%)
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSI 169
E+ D ++ +E + SP G T T S E+ ++ + VE S
Sbjct: 2207 EQQRLQDELELTRRALEKERLHSP------GATSTAELGSRGEQGVQLGEVSGVEAEPSP 2260
Query: 170 EDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDI--------- 218
+ +E R + QAVA+LE +R +L V LR L++V++ + +
Sbjct: 2261 DGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRS-TLEQVERERRKLKREAMRAAQ 2319
Query: 219 ---LAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFRE 275
L K A + ++DG R + + + ++ KE V Q QL ++ +
Sbjct: 2320 AGSLEISKATASSPTQQDG-RGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYI---- 2374
Query: 276 VLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQES 321
TR+ Q S ELA L + + Q EA + + L ES
Sbjct: 2375 ---TRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDES 2417
Score = 30.8 bits (68), Expect = 2.9
Identities = 29/122 (23%), Positives = 54/122 (44%), Gaps = 6/122 (4%)
Query: 325 SAQFENLMAESRQ-DLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEAR 383
S N+ +S Q LEE+ ++ E + A + L+ +Q Q +R LQA+
Sbjct: 5 SPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVL 64
Query: 384 QLRLQNRNLEDQI-----ALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEM 438
Q R + LE ++ + ++ + E E L +EE Q++ + ++ Q M
Sbjct: 65 QYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHM 124
Query: 439 EQ 440
E+
Sbjct: 125 EK 126
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 71.2 bits (173), Expect = 2e-12
Identities = 80/400 (20%), Positives = 180/400 (45%), Gaps = 17/400 (4%)
Query: 62 EDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPD-RIQF 120
E +L E L + ETEK+E L+I+E + E + P + + E + +++
Sbjct: 11 EKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVRE 70
Query: 121 VEGPV--EPGKPTSPEHVVYEGETVTRAEKSNPEES---LRAEQSPSVEENLSIEDLE-L 174
EG V + G+ E V E E R ++ E +R ++ E+ + + E
Sbjct: 71 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 130
Query: 175 LEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDG 234
+ + Q + Q+ E+ Q+ + +RE Q +Q Q + Q +
Sbjct: 131 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ----VREQEGQVREQEGQ 186
Query: 235 LREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLR-- 292
+RE+ + ++ ++ ++ Q E Q+ Q + E + + Q+ E+ Q++
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ 246
Query: 293 -DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLL 351
+ QKQ+EQ+R+Q E Q + QE + L + + E + EE+ Q ++
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 352 ERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNL---EDQIALVRQKRDEEVQ 408
E++E + ++ + + ++M + + + Q+ Q + E+Q+ ++ ++ +
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEE 366
Query: 409 QYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEE 448
Q R+Q E+M +++ Q+R + +++ ++M + + + E+
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ 406
Score = 45.8 bits (107), Expect = 9e-05
Identities = 62/301 (20%), Positives = 141/301 (46%), Gaps = 22/301 (7%)
Query: 188 QLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF 247
+L+E+ +L EL L+ E E+Q L +L + E ++ L +E ++ +Q+
Sbjct: 8 ELKEKNAELQEELQLV-ETEKSEIQ------LHIKELKRKLETDKIPLPQEGQVREQEGQ 60
Query: 248 KVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDA---YQKQKEQLRQ 304
+E + + + R+Q+ Q + + + Q+ E+ Q+R+ ++Q+ Q+R+
Sbjct: 61 VREQEGQVREQEGQVREQE-GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 119
Query: 305 QLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRT 364
Q E +++G ++ ++ Q + + Q E+E + + R++ G Q
Sbjct: 120 Q-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 178
Query: 365 QAEIQE--MKEALRPLQAEARQLRLQNRNLEDQIALVRQK------RDEEVQQYREQLEE 416
Q QE ++E + + Q+ Q + +Q ++++ ++E++++ EQ+ E
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMET 476
EE+ ++ VQ Q+++ ++ E+ E++ + +L K EQ + Q G E
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQML-KQKEQTE-QEEQTGEQEE 296
Query: 477 Q 477
Q
Sbjct: 297 Q 297
>gi|14917117 keratin 33A [Homo sapiens]
Length = 404
Score = 71.2 bits (173), Expect = 2e-12
Identities = 68/316 (21%), Positives = 143/316 (45%), Gaps = 42/316 (13%)
Query: 170 EDLELLEGRFQQCVQAVAQLEE---ERDQLIHELVLLREPAL--------QEVQQVHQDI 218
E ++ L R ++ V QLE E + LI E +EP + + ++++ Q I
Sbjct: 58 ETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCASYQSYFKTIEELQQKI 117
Query: 219 LAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLT 278
L + +A+ ++ D + + K Y+ +L RQ + R +L
Sbjct: 118 LCSKSENARLVVQIDNAKLASDDFRTK----------YETELSLRQLVESDINGLRRILD 167
Query: 279 ----------TRATQLSEELAQLRDAYQKQKEQLRQQL--------EAPPSQRDGHFLQE 320
+ L EEL L+ ++++ LR QL +A P+ L E
Sbjct: 168 ELTLCRSDLEAQVESLKEELLCLKQNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNQVLNE 227
Query: 321 SRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQA 380
+R +Q+E L+ +R+++E+ + Q L ++ + ++ LQ QAEI E++ + L+
Sbjct: 228 TR---SQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEI 284
Query: 381 EARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQ 440
E + +LE+ + + ++ Q + + +E + ++R+ ++ Q Q+ + +
Sbjct: 285 ELQAQHNLRDSLENTLTESEARYSSQLSQVQRLITNVESQLAEIRSDLERQNQEYQVLLD 344
Query: 441 LRLSLAEELSTYKAML 456
+R L E++TY+++L
Sbjct: 345 VRARLECEINTYRSLL 360
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 70.1 bits (170), Expect = 4e-12
Identities = 74/322 (22%), Positives = 141/322 (43%), Gaps = 21/322 (6%)
Query: 155 LRAEQSPSVEE--NLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
LR + PS++ E ++ L +F + V LE++ L + LL+E +
Sbjct: 76 LRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSS 135
Query: 213 QVHQDILAAYKLHAQAELER---DGLREEIRL---------VKQKLFKVTKECVAYQYQL 260
++ DI A + +LE DG R E L K K A + +
Sbjct: 136 RL-PDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEF 194
Query: 261 ECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLE------APPSQRD 314
++DV + L + L++E+ LR + + +L+ Q+ + + R
Sbjct: 195 VVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRS 254
Query: 315 GHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
+ AQ+E + SR + E Y+ +F L + L+ T+ EI EM A
Sbjct: 255 LDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRA 314
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
++ LQAE ++ Q LE IA ++ + ++ R + EE+E ++ + + Q ++
Sbjct: 315 IQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLRE 374
Query: 435 NKEMEQLRLSLAEELSTYKAML 456
+E+ ++L+L E++TY+ +L
Sbjct: 375 YQELMSVKLALDIEIATYRKLL 396
>gi|14917119 keratin 34 [Homo sapiens]
Length = 436
Score = 70.1 bits (170), Expect = 4e-12
Identities = 68/309 (22%), Positives = 142/309 (45%), Gaps = 28/309 (9%)
Query: 170 EDLELLEGRFQQCVQAVAQLEE---ERDQLIHELVLLREPAL--------QEVQQVHQDI 218
E ++ L R ++ V QLE E ++LI E +EP L + ++++ Q I
Sbjct: 100 ETMQFLNDRLASYLEKVRQLERDNAELEKLIQERSQQQEPLLCPSYQSYFKTIEELQQKI 159
Query: 219 LAAYKLHAQ-------AELERDGLREEIRLVKQKLFKVTKECVAYQYQLE----CRQQDV 267
L A +A+ A+L D R + + + V + + + L+ C+
Sbjct: 160 LCAKAENARLVVNIDNAKLASDDFRSKYQTEQSLRLLVESDINSIRRILDELTLCKSDLE 219
Query: 268 AQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQ 327
+Q RE L EE+ LR + ++L +++ P+ L E+R +Q
Sbjct: 220 SQVESLREELICLKKNHEEEVNTLRS---QLGDRLNVEVDTAPTVDLNQVLNETR---SQ 273
Query: 328 FENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRL 387
+E L+ +R+++E+ + Q L ++ + ++ LQ QAEI E++ + L+ E +
Sbjct: 274 YEALVEINRREVEQWFATQTEELNKQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHN 333
Query: 388 QNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAE 447
+LE+ + ++ Q + + +E + ++R ++ Q Q+ + + +R L
Sbjct: 334 LRDSLENTLTESEAHYSSQLSQVQSLITNVESQLAEIRCDLERQNQEYQVLLDVRARLEC 393
Query: 448 ELSTYKAML 456
E++TY+++L
Sbjct: 394 EINTYRSLL 402
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 70.1 bits (170), Expect = 4e-12
Identities = 70/336 (20%), Positives = 155/336 (46%), Gaps = 22/336 (6%)
Query: 153 ESLRAEQSPSVEENLSIED-LELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEV 211
E LR++ + VEEN +++ LE EG ++ ++ + Q++ ER+Q E+ L++ ++
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQD----QL 707
Query: 212 QQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
++H ++ +A + + E+ L EE+ KQ L + +A + Q + ++ +
Sbjct: 708 SEMHDELDSAKR---SEDREKGALIEELLQAKQDLQDL---LIAKEEQEDLLRKRERELT 761
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENL 331
+ L + +E+ +L++ Y + + LR+ +E + + SR +++ +
Sbjct: 762 ALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVE---VLASRSNTSEQDQA 818
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQ----EMKEALRPLQAEARQLR- 386
E R L +E + E E LQR +++ + KE L+ + E RQL
Sbjct: 819 GTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEE 878
Query: 387 --LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLS 444
+ R E + R+ + E++ + L + + Q+QL ++ + ++ +++ +L+
Sbjct: 879 ALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE 938
Query: 445 LAEELSTYKAMLLPKSLEQAD-APTSQAGGMETQSQ 479
+ E + E AD S+ +E Q+Q
Sbjct: 939 MENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQ 974
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/291 (18%), Positives = 131/291 (45%), Gaps = 11/291 (3%)
Query: 165 ENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKL 224
E L E +++E ++ QL+E +++ EL ++ ++ + + L A K+
Sbjct: 951 EKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 1010
Query: 225 HAQAELERDGLREEIR-----LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTT 279
+ L + LR+ R L K++L + T + + +Y+LE + + + +
Sbjct: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDL--EYELEAKSHLKDDRSRLVKQMED 1068
Query: 280 RATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDL 339
+ +QL EL + R+ E++ + E R+ + + R + + + E +
Sbjct: 1069 KVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN-- 1126
Query: 340 EEEYEPQFLRLLERKEAGTKALQ-RTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIAL 398
++ + + + L + + L + +A I E+++ L + + L+L NR LE ++
Sbjct: 1127 -KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKE 1185
Query: 399 VRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ + D+E +Q +++ R + ++ V+ +++ +E + L EL
Sbjct: 1186 LVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQREL 1236
Score = 46.2 bits (108), Expect = 7e-05
Identities = 95/409 (23%), Positives = 162/409 (39%), Gaps = 59/409 (14%)
Query: 69 ETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPG 128
E L Q EK EE +++ ++ E E N EE V+ E + + + ++
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEG---ELRKNLEELFQVKMEREQHQTEIRD--LQDQ 706
Query: 129 KPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQ 188
+ + + R + + EE L+A+Q E +LL R ++
Sbjct: 707 LSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGA 766
Query: 189 LEEERDQLIHELVLLREPALQEVQQVHQDILAAYKL--------------HAQAELERDG 234
L+EE E+ L+E E+Q + + + A K A E+
Sbjct: 767 LKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL 826
Query: 235 LREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDA 294
L+EE ++ + ++ + Q Q+E + D A+ + + QL E L R
Sbjct: 827 LQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKE 886
Query: 295 YQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQD-----LEEEYEPQFLR 349
+K+ R+ LE G+ Q ++ E L ES Q L+ E E
Sbjct: 887 -EKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN---- 941
Query: 350 LLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQ 409
ER G K +++ Q E+ ++ EA R L LQN+ DE ++
Sbjct: 942 --ERWHLG-KTIEKLQKEMADIVEASR-----TSTLELQNQ------------LDEYKEK 981
Query: 410 YREQLEEMEERQRQLRNGVQLQQQKN-----KEMEQLRLSLAEELSTYK 453
R +L EM QRQL+ L+ +K+ K +++RL + EEL Y+
Sbjct: 982 NRRELAEM---QRQLKEKT-LEAEKSRLTAMKMQDEMRL-MEEELRDYQ 1025
Score = 35.4 bits (80), Expect = 0.12
Identities = 30/124 (24%), Positives = 60/124 (48%), Gaps = 11/124 (8%)
Query: 325 SAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQ 384
SAQ N S ++++ E + +E E + LQ Q +KE ++A +
Sbjct: 595 SAQGNNQACNSTSEVKDLLEQKSKLTIEVAEL-QRQLQLEVKNQQNIKEERERMRANLEE 653
Query: 385 LRLQNRNLEDQIALVRQKRDEEVQQYREQLEEM-------EERQRQLRNGVQLQQQKNKE 437
LR Q+ ++ + ++Q+ +E + R+ LEE+ E+ Q ++R+ LQ Q ++
Sbjct: 654 LRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRD---LQDQLSEM 710
Query: 438 MEQL 441
++L
Sbjct: 711 HDEL 714
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,954,744
Number of Sequences: 37866
Number of extensions: 877021
Number of successful extensions: 13716
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 473
Number of HSP's successfully gapped in prelim test: 972
Number of HSP's that attempted gapping in prelim test: 5544
Number of HSP's gapped (non-prelim): 4681
length of query: 482
length of database: 18,247,518
effective HSP length: 106
effective length of query: 376
effective length of database: 14,233,722
effective search space: 5351879472
effective search space used: 5351879472
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.