Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 166197688
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166197688 neuronal guanine nucleotide exchange factor
isoform 1 [Homo sapiens]
(710 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166197688 neuronal guanine nucleotide exchange factor isoform... 1421 0.0
gi|166197690 neuronal guanine nucleotide exchange factor isoform... 1161 0.0
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens] 372 e-103
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom... 369 e-102
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 324 2e-88
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 317 3e-86
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens] 284 2e-76
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 107 3e-23
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 103 6e-22
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 103 6e-22
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 98 2e-20
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 97 5e-20
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 86 2e-16
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 84 5e-16
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 84 5e-16
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 83 8e-16
gi|38373682 pleckstrin homology domain containing family G membe... 82 2e-15
gi|111154084 pleckstrin homology domain containing family G memb... 82 2e-15
gi|111154088 pleckstrin homology domain containing family G memb... 82 2e-15
gi|111154080 pleckstrin homology domain containing family G memb... 82 2e-15
gi|111154078 pleckstrin homology domain containing family G memb... 82 2e-15
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 81 3e-15
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 80 9e-15
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 80 9e-15
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 80 9e-15
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 80 9e-15
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 80 9e-15
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 80 9e-15
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 72 1e-12
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 72 1e-12
>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 710
Score = 1421 bits (3679), Expect = 0.0
Identities = 710/710 (100%), Positives = 710/710 (100%)
Query: 1 METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIK 60
METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIK
Sbjct: 1 METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIK 60
Query: 61 RNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQT 120
RNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQT
Sbjct: 61 RNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQT 120
Query: 121 DPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQ 180
DPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQ
Sbjct: 121 DPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQ 180
Query: 181 EYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQIC 240
EYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQIC
Sbjct: 181 EYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQIC 240
Query: 241 LLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM 300
LLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM
Sbjct: 241 LLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM 300
Query: 301 ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHF 360
ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHF
Sbjct: 301 ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHF 360
Query: 361 SVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLK 420
SVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLK
Sbjct: 361 SVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLK 420
Query: 421 LLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKS 480
LLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKS
Sbjct: 421 LLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKS 480
Query: 481 VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVF 540
VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVF
Sbjct: 481 VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVF 540
Query: 541 DSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR 600
DSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR
Sbjct: 541 DSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR 600
Query: 601 RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQER 660
RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQER
Sbjct: 601 RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQER 660
Query: 661 GWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ 710
GWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
Sbjct: 661 GWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ 710
>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 618
Score = 1161 bits (3004), Expect = 0.0
Identities = 583/583 (100%), Positives = 583/583 (100%)
Query: 128 SESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKST 187
SESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKST
Sbjct: 36 SESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKST 95
Query: 188 LQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHS 247
LQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHS
Sbjct: 96 LQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHS 155
Query: 248 RFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRK 307
RFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRK
Sbjct: 156 RFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRK 215
Query: 308 ILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV 367
ILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV
Sbjct: 216 ILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV 275
Query: 368 SNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNIL 427
SNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNIL
Sbjct: 276 SNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNIL 335
Query: 428 KRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHS 487
KRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHS
Sbjct: 336 KRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHS 395
Query: 488 RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGL 547
RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGL
Sbjct: 396 RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGL 455
Query: 548 LRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSF 607
LRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSF
Sbjct: 456 LRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSF 515
Query: 608 TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM 667
TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM
Sbjct: 516 TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM 575
Query: 668 TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ 710
TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
Sbjct: 576 TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ 618
>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
Length = 1597
Score = 372 bits (955), Expect = e-103
Identities = 238/618 (38%), Positives = 336/618 (54%), Gaps = 39/618 (6%)
Query: 76 KARDNPERNASCLADSQDNGKSV--NEPLTLNIPWSRMPPCRTAMQTDPGAQEMSESSST 133
KA P R S +G++V +E + WSR R ++ + S+
Sbjct: 1001 KASSWPHRRDSGRPPGDSSGQAVAPSEGANKHKGWSRQGLRRPSILPE---------GSS 1051
Query: 134 PGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIET 193
G E+ P +D+ + + + + LI LLYQEY D +EI++
Sbjct: 1052 DSRGPAVEKHPGPSDTVVFREKKPKEVMGGFSRRCSKLINSSQLLYQEYSDVVLNKEIQS 1111
Query: 194 RRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQ 253
QQ E T G P+S P + E L ++ + S+ +LWQ
Sbjct: 1112 --QQRLESLSETPG-PSSPRQPRKALVSSESY----------LQRLSMASSG----SLWQ 1154
Query: 254 DLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSE 313
++P +R+S VL + E+ KLQE FEL+ SEASY +SLN+ V HF + +R L E
Sbjct: 1155 EIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQE 1214
Query: 314 AHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQ 373
LFS + DV VS FL +LE E NI VCD+V +A D VY+ YV+NQTYQ
Sbjct: 1215 HQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQ 1274
Query: 374 ERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEER 433
ERT++ L+ + FRE++ +LE DP C+ L SFLILPFQRITRLKLL+QNILKR +
Sbjct: 1275 ERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPG 1334
Query: 434 SERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQ 493
S E A AH LE +++ CN V+ M RTE++I + +K+EF+ K P+IS SRWL+K
Sbjct: 1335 SSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKS 1394
Query: 494 GELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEEL 553
GEL + S LR K ++L LFND L++ R G ++ VFD AP +R E+
Sbjct: 1395 GELTALEF-SASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKC 1453
Query: 554 EDQ-GQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLL 612
E + N+F L L +N +A ++ + +QSE RW+++LA R LL
Sbjct: 1454 EMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPRE------ELDLL 1507
Query: 613 DC---PQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTE 669
+C PQVQC+ Y ++ DEL LE AD++ + ++ DGW+ G RL D ERGWFP E
Sbjct: 1508 ECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVE 1567
Query: 670 EILNPKIRSQNLKECFRV 687
I NP++R+QNLKE RV
Sbjct: 1568 FISNPEVRAQNLKEAHRV 1585
>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
sapiens]
Length = 802
Score = 369 bits (948), Expect = e-102
Identities = 214/515 (41%), Positives = 309/515 (60%), Gaps = 21/515 (4%)
Query: 177 LLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTL 236
+LYQEY D ++ +E+ RRQQ E+ P +E E EE PP
Sbjct: 293 VLYQEYSDVASAREL--RRQQ------------REEEGPGDEAEGAEEGP--GPPRANLS 336
Query: 237 PQICLLSNPHSR---FNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLN 293
P + +R F+LWQD+P++R SGVL L + KLQEA FEL+TSEASY SL+
Sbjct: 337 PSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLS 396
Query: 294 LLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVY 353
+ V HF+ + + + L + LFS + +V + SERFL +LE R+E +++ VCD+V
Sbjct: 397 VAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVL 456
Query: 354 RYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPF 413
+ VY+ YV+NQ YQERTY++LL E F ++A+LE P C+ LP +SFLILPF
Sbjct: 457 DHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPF 516
Query: 414 QRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKK 473
QRITRLK+LV+NILKR + SE E A A L+ +V+ CN V+ M RTE++I + KK
Sbjct: 517 QRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKK 576
Query: 474 MEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIP 533
+ F+ K P+IS +RWL++ GEL +++ + + K +YL LFND L++ R+
Sbjct: 577 IHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKE 636
Query: 534 GDKYQVFDSAPRGLLRVEELEDQGQTL-ANVFILRLLENADDREATYMLKASSQSEMKRW 592
K+ VF A L+V +L + Q + +VF+L+LL + + ++L+A ++SE +RW
Sbjct: 637 LGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLL-HGQHMKHQFLLRARTESEKQRW 695
Query: 593 MTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFG 652
+++L P+ + S DCPQVQCV Y A PDELTLE DIL++ T DGW+ G
Sbjct: 696 ISALCPSSPQEDKEVISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEG 755
Query: 653 ERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRV 687
RL D E+GW P + EEI + R +NL+E RV
Sbjct: 756 VRLADGEKGWVPQAYVEEISSLSARLRNLRENKRV 790
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 324 bits (831), Expect = 2e-88
Identities = 179/487 (36%), Positives = 287/487 (58%), Gaps = 17/487 (3%)
Query: 217 EEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQE 276
+E +++ +E +SP + + ++ + W LPE+ G+L+ L EE K QE
Sbjct: 228 QESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQE 287
Query: 277 AMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELE 336
AMFE++TSE SY SL++LV F++++ +R + E H LFSN+LDVL S+RF +LE
Sbjct: 288 AMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLE 347
Query: 337 HRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLEL 396
R + +++ D+ DI+ +A HF YI Y SN+ YQ+RT ++L+ AAFRE + ++E
Sbjct: 348 QRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIER 407
Query: 397 DPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNE 456
P C GLP SFLILP QR+TRL LL+ + + + SER A A K + +V+ CNE
Sbjct: 408 RPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNE 467
Query: 457 GVRKMSRTEQMISIQKKMEF-KIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFH 515
G +M R EQM ++ +++F K+KS+P+IS SRWLLK+GEL + R + ++
Sbjct: 468 GAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRP--- 524
Query: 516 EIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELE----------DQGQTLANVFI 565
YLFLFND+LV+ ++ + Y V D A ++VE++E ++ ++ + F
Sbjct: 525 TCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQ 584
Query: 566 LRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVA 625
+ LL N++ R+ +L + S S+ RW+ +L + R ++ +S+ D PQV+ + A
Sbjct: 585 VTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSER-QWQGLSSK-GDLPQVEITKAFFA 642
Query: 626 QQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECF 685
+Q DE+TL+ AD++ +L + +DGW++GERL D E GWFP I + N++
Sbjct: 643 KQADEVTLQQADVVLVLQQ-EDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRME 701
Query: 686 RVHKMDD 692
R+ D
Sbjct: 702 RLRVETD 708
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 317 bits (811), Expect = 3e-86
Identities = 187/557 (33%), Positives = 303/557 (54%), Gaps = 37/557 (6%)
Query: 148 DSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNG 207
DSPT+ + RM P+ + ++ ++ S+L I+ + + D
Sbjct: 328 DSPTSSKKKNRMSQPV-----------LKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEEN 376
Query: 208 SPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEIL 267
+ ++ E+ + + +EE + P E+K+ +I + P + W L ++ G+ + +
Sbjct: 377 AVLYQNYKEKALDIDSDEE-SEPKEQKSDEKIVIHHKPLR--STWSQLSAVKRKGLSQTV 433
Query: 268 QPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAV 327
EE K QEA+FE+++SE SY SL +L+ F ++ + + +E H LFSN+ DV
Sbjct: 434 SQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEA 493
Query: 328 SERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAF 387
S++F +ELE R + NI I D+ DIV ++ A F Y+ Y +N+ YQ+RT ++LL +F
Sbjct: 494 SKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSF 553
Query: 388 RELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKEL 447
+E+++++E CR LP SFLILP QR+TRL LL+ I ++ + S + A KE+
Sbjct: 554 KEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEV 613
Query: 448 EMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRT 507
+V+ CNEG RKM RTE M +I ++EFKIK P++S SRWL+K+GEL +
Sbjct: 614 SKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFS 673
Query: 508 LRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQ----------- 556
RT K ++Y FLFND+L+I ++ + Y V D + R L VE +++
Sbjct: 674 RRTSK--QQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSS 731
Query: 557 ------GQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSR 610
+ +++F L +L N + + +L A +QSE RW+T+L + TS
Sbjct: 732 TMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTS- 790
Query: 611 LLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEE 670
QV+ V + A+QPDEL+L++AD++ I + DGW GERL D ERGWFP +E
Sbjct: 791 ---LTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKE 847
Query: 671 ILNPKIRSQNLKECFRV 687
I +N++ R+
Sbjct: 848 ITCQATIDKNVERMGRL 864
>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
Length = 841
Score = 284 bits (726), Expect = 2e-76
Identities = 170/465 (36%), Positives = 262/465 (56%), Gaps = 15/465 (3%)
Query: 221 EEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFE 280
E+ PA+ + T P+ P R LWQ+LP +++SG+L+ L P+E ++QE++FE
Sbjct: 370 EDGSPSPANAGDAPTFPR-----PPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFE 424
Query: 281 LVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRME 340
+VTSEASY +SL LL F+ ++ +R L P + H LFSNV V VSERFL L R+
Sbjct: 425 VVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVR 484
Query: 341 ENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKC 400
+ ISD+CD+V+ +A FSVY+ YV NQ YQE TY +L+ F + +L+ PKC
Sbjct: 485 SSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKC 544
Query: 401 RGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRK 460
LP SFL+LPFQRITRL++L+QNIL++ EE S R+ A A + +++ C+ V +
Sbjct: 545 ERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGR 604
Query: 461 MSRTEQMISIQKKMEF-KIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYL 519
M +TE++I + +++ F K+K++P++S SR L QGEL ++ + ++ F + L
Sbjct: 605 MKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCL 664
Query: 520 FLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATY 579
LF+DLL+I + G + QV D A R L++ +++ D F L LL N R
Sbjct: 665 LLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSG--PPTFRLSLLSNHQGRPTHR 722
Query: 580 MLKASSQSEMKRWMTSL-APNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADI 638
+L+ASS S+M+RW+ + P DC Q C + + +LE
Sbjct: 723 LLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAA 782
Query: 639 LNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKE 683
L KT +GW+ G G FP+ + E+ R ++L++
Sbjct: 783 PKHLHKTPEGWLKG------LPGAFPAQLVCEVTGEHERRRHLRQ 821
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 107 bits (268), Expect = 3e-23
Identities = 75/272 (27%), Positives = 133/272 (48%), Gaps = 15/272 (5%)
Query: 263 VLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVL 322
+L++L P E K Q + EL+ +E +Y L L+ F + ++L E ++F N
Sbjct: 1227 LLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWK 1286
Query: 323 DVLAVSERFLLELEHRME---ENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQ 379
+++ + + L L R + E + + + DI+ H YI + S Q +Q
Sbjct: 1287 ELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLP-HMQPYIRFCSRQLNGAALIQQ 1345
Query: 380 LLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECT 439
E F+E + +L +DP+C+G+P SSF++ P QR+TR L+++NIL+ E
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 440 ALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQM 499
A ++ E + NEGVR+ ++++ IQ ++ + S ++ +S +
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS--------VTNC 1457
Query: 500 SGPKT---SRTLRTKKLFHEIYLFLFNDLLVI 528
GP+ S L K E+Y FLFND L++
Sbjct: 1458 LGPRKFLHSGKLYKAKSNKELYGFLFNDFLLL 1489
Score = 39.3 bits (90), Expect = 0.013
Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 3/66 (4%)
Query: 616 QVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPK 675
Q Q ++P+ A++ + L D++ +L++ D W FGE ++GWFP S + I P
Sbjct: 917 QAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGE--VQGQKGWFPKSYVKLISGPI 973
Query: 676 IRSQNL 681
+S ++
Sbjct: 974 RKSTSM 979
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/51 (39%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Query: 616 QVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSS 666
QV ++ Y AQ DEL I+N+L+K D W GE + + G FPS+
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGE--VNGQVGLFPSN 1207
Score = 34.7 bits (78), Expect = 0.31
Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 4/60 (6%)
Query: 618 QCVHPYVAQQPDELTLELADILNILDKTDDGWIFGE---RLHDQERGWFPSSMTEEILNP 674
Q + Y A P++LTL ++ I K GW GE R ++ GWFP++ ++L+P
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV-KLLSP 1138
Score = 33.1 bits (74), Expect = 0.91
Identities = 17/61 (27%), Positives = 37/61 (60%), Gaps = 9/61 (14%)
Query: 618 QCVHPYVAQQPDELTLELADILNI----LDKT---DDGWIFGERLHDQERGWFPSSMTEE 670
+ ++P+ ++ DE+T++ DI+ + +D++ + GW+ GE + GWFP++ E+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGEL--KGKTGWFPANYAEK 803
Query: 671 I 671
I
Sbjct: 804 I 804
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 103 bits (257), Expect = 6e-22
Identities = 78/273 (28%), Positives = 133/273 (48%), Gaps = 19/273 (6%)
Query: 264 LEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLD 323
L+ +QP E K Q + EL+ +E Y L L+V F + L E ++F N +
Sbjct: 1173 LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKE 1232
Query: 324 VLAVSERFLLELEHRME---ENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQL 380
++ + + L L R + E + + + DI+ + H YI + S Q +Q
Sbjct: 1233 LIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELS-HMQAYIRFCSCQLNGAALLQQK 1291
Query: 381 LQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA 440
E F+E + +L DP+C+G+P SSFL+ P QRITR LL+++IL+ E +
Sbjct: 1292 TDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSL 1351
Query: 441 LDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMS 500
A + E + NEGVR+ ++++ IQ ++ + + +I +S L
Sbjct: 1352 KLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNS--------LTNCL 1403
Query: 501 GPKTSRTLRTKKLF-----HEIYLFLFNDLLVI 528
GP+ + L + KL+ E++ FLFND L++
Sbjct: 1404 GPR--KLLHSGKLYKTKSNKELHGFLFNDFLLL 1434
Score = 36.6 bits (83), Expect = 0.083
Identities = 16/56 (28%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 618 QCVHPYVAQQPDELTLELADILNILDKT--DDGWIFGERLHDQERGWFPSSMTEEI 671
+ ++P+ A+ DE++ DI+ + +KT + GW++G GWFP + E++
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS--FQGNFGWFPCNYVEKM 789
Score = 36.2 bits (82), Expect = 0.11
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 3/52 (5%)
Query: 618 QCVHPYVAQQPDELTLELADILNILDKTDDGWIFGE---RLHDQERGWFPSS 666
Q YVA ++L+L ++ IL K GW GE R +++GWFP+S
Sbjct: 1032 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPAS 1083
Score = 33.1 bits (74), Expect = 0.91
Identities = 18/64 (28%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 616 QVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPK 675
+ Q + + A++ + L DI+ +L++ ++ W FGE +H RGWFP S + I +
Sbjct: 875 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWW-FGE-VHGG-RGWFPKSYVKIIPGSE 931
Query: 676 IRSQ 679
++ +
Sbjct: 932 VKRE 935
Score = 33.1 bits (74), Expect = 0.91
Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 616 QVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSS 666
QV ++ Y A DEL+ ++N+++K D W GE + G FPS+
Sbjct: 1104 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE--INGVTGLFPSN 1152
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 103 bits (257), Expect = 6e-22
Identities = 78/273 (28%), Positives = 133/273 (48%), Gaps = 19/273 (6%)
Query: 264 LEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLD 323
L+ +QP E K Q + EL+ +E Y L L+V F + L E ++F N +
Sbjct: 1200 LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKE 1259
Query: 324 VLAVSERFLLELEHRME---ENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQL 380
++ + + L L R + E + + + DI+ + H YI + S Q +Q
Sbjct: 1260 LIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELS-HMQAYIRFCSCQLNGAALLQQK 1318
Query: 381 LQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA 440
E F+E + +L DP+C+G+P SSFL+ P QRITR LL+++IL+ E +
Sbjct: 1319 TDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSL 1378
Query: 441 LDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMS 500
A + E + NEGVR+ ++++ IQ ++ + + +I +S L
Sbjct: 1379 KLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNS--------LTNCL 1430
Query: 501 GPKTSRTLRTKKLF-----HEIYLFLFNDLLVI 528
GP+ + L + KL+ E++ FLFND L++
Sbjct: 1431 GPR--KLLHSGKLYKTKSNKELHGFLFNDFLLL 1461
Score = 36.6 bits (83), Expect = 0.083
Identities = 16/56 (28%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 618 QCVHPYVAQQPDELTLELADILNILDKT--DDGWIFGERLHDQERGWFPSSMTEEI 671
+ ++P+ A+ DE++ DI+ + +KT + GW++G GWFP + E++
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS--FQGNFGWFPCNYVEKM 816
Score = 36.2 bits (82), Expect = 0.11
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 3/52 (5%)
Query: 618 QCVHPYVAQQPDELTLELADILNILDKTDDGWIFGE---RLHDQERGWFPSS 666
Q YVA ++L+L ++ IL K GW GE R +++GWFP+S
Sbjct: 1059 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPAS 1110
Score = 33.1 bits (74), Expect = 0.91
Identities = 18/64 (28%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 616 QVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPK 675
+ Q + + A++ + L DI+ +L++ ++ W FGE +H RGWFP S + I +
Sbjct: 902 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWW-FGE-VHGG-RGWFPKSYVKIIPGSE 958
Query: 676 IRSQ 679
++ +
Sbjct: 959 VKRE 962
Score = 33.1 bits (74), Expect = 0.91
Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 616 QVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSS 666
QV ++ Y A DEL+ ++N+++K D W GE + G FPS+
Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE--INGVTGLFPSN 1179
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 98.2 bits (243), Expect = 2e-20
Identities = 97/400 (24%), Positives = 172/400 (43%), Gaps = 57/400 (14%)
Query: 209 PASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQ 268
P S++ + EEE++EEE +P ++E +
Sbjct: 330 PGSQEVDSDLEEEDDEEEEEEKDREIPVP-------------------------LMERQE 364
Query: 269 PEEIKLQEAMF----ELVTSEASYYKSLNLLVSHF----MENERIRKILHPSEAHILFSN 320
E+ +Q+ +F EL+ +E +Y L+LL F +E R R H +FSN
Sbjct: 365 SVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSN 424
Query: 321 VLDVLAVSERFLL-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQ 379
+ + ++FLL ELE RMEE + DI+ + A +Y YV N
Sbjct: 425 ICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAP-FLKMYGEYVKNFDRAVELVNT 483
Query: 380 LLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECT 439
+ F+ +I +++ + C L ++ P QRI R +LL+++ L ++ S
Sbjct: 484 WTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSP---D 540
Query: 440 ALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQM 499
+ DA K LE++ A + + E+M + K E I+S ++ L+K+G + ++
Sbjct: 541 SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKL 600
Query: 500 SGPKTSRTLRTKKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQ 556
S K T + YL LFND L+ C ++ G K+ V A + +E E
Sbjct: 601 SA-KNGTT-------QDRYLILFNDRLLYCVPRLRLLGQKFSV--RARIDVDGMELKESS 650
Query: 557 GQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596
L F++ ++ + L+A ++ E K W+ ++
Sbjct: 651 NLNLPRTFLV------SGKQRSLELQARTEEEKKDWVQAI 684
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 97.1 bits (240), Expect = 5e-20
Identities = 100/398 (25%), Positives = 176/398 (44%), Gaps = 57/398 (14%)
Query: 209 PASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQ 268
P E E E + +E E SP E + L Q H E+ +
Sbjct: 166 PLEERGAETETKVQERENGESPLELEQLDQ-------HH-----------------EMKE 201
Query: 269 PEEIKLQEAMFELVTSEASYYKSLNLLVSHFMEN--ERIRKILHPSE-AHILFSNVLDVL 325
E KL + EL+ +E +Y L+LL F E + P+E + +FSN+ +
Sbjct: 202 TNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSIN 261
Query: 326 AVSERFLL-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEK 384
A +FLL ELE RM+E + DI+ + A +Y YV K + +
Sbjct: 262 AFHSKFLLPELEKRMQEWETTPRIGDILQKLAP-FLKMYGEYVKGFDNAMELVKNMTERI 320
Query: 385 AAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAH 444
F+ ++ +++ C L ++ P QRI R ++L+++ L+++ S DA
Sbjct: 321 PQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDS---LDWNDAK 377
Query: 445 KELEMVVKAC---NEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSG 501
K LE++ A N +RKM ++++ I + + + I++ S L+K+G++ +++
Sbjct: 378 KSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG---EEEDIVNPSNELIKEGQILKLAA 434
Query: 502 PKTSRTLRTKKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQGQ 558
TS E YLFLFN++L+ C + G K+ V G+ ++ +E Q +
Sbjct: 435 RNTSA--------QERYLFLFNNMLLYCVPKFSLVGSKFTVRTRV--GIDGMKIVETQNE 484
Query: 559 TLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596
+ F +E T L+ASS + + W+ +L
Sbjct: 485 EYPHTF------QVSGKERTLELQASSAQDKEEWIKAL 516
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 85.5 bits (210), Expect = 2e-16
Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 20/340 (5%)
Query: 209 PASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLP-------EIRSS 261
P + EEE E E E +P + + + DL ++ S
Sbjct: 716 PPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSR 775
Query: 262 GVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNV 321
VL L+P EIK QE + EL +E ++ ++L +L F + IL PSE +FSN+
Sbjct: 776 EVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNL 835
Query: 322 LDVLA--VSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYI-----TYVSNQTYQE 374
D+L + ++ + E VI + + + + + + T+ SNQ +
Sbjct: 836 EDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFAL 895
Query: 375 RTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERS 434
K ++ + F+ + E +P CR L + QR+T+ LL+ NI K E +
Sbjct: 896 EMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPT 955
Query: 435 ERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKME---FKIKSVPIISHSRWLL 491
ERE A ++ N+ V++ +++ Q++++ K+ P + R L
Sbjct: 956 ERE-KVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLD 1014
Query: 492 KQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQ 531
GP + R K + ++Y L D+LV+ ++
Sbjct: 1015 LTKRKMIHEGPLVWKVNRDKTI--DLYTLLLEDILVLLQK 1052
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 84.0 bits (206), Expect = 5e-16
Identities = 90/386 (23%), Positives = 171/386 (44%), Gaps = 51/386 (13%)
Query: 214 TPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIK 273
TP+EE + + EEP S + PQ + +G+ + P+ K
Sbjct: 121 TPQEEADSDVGEEPDS----ENTPQ-----------------KADKDAGLAQHSGPQ--K 157
Query: 274 LQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHI-LFSNVLDVLAVSERFL 332
L EL+ +E +Y K L+LL F R+ P E + +FSN+ + +FL
Sbjct: 158 LLHIAQELLHTEETYVKRLHLLDQVFCT--RLTDAGIPPEVIMGIFSNISSIHRFHGQFL 215
Query: 333 L-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELI 391
L EL+ R+ E + + + A +Y YV N Q F++++
Sbjct: 216 LPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVV 275
Query: 392 AQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRV-EERSERECTALDAHKELEMV 450
++ C L ++ P QR+ R +LL+++ LKR+ ++ +R+ DA + LE++
Sbjct: 276 HSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK----DAERSLELI 331
Query: 451 VKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRT 510
A N + + E+M + + E I++ + L+K+G++Q++S + R
Sbjct: 332 STAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDR- 390
Query: 511 KKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILR 567
+LFLFN +++ C ++ G K+ V + L+V+++ A+ FI+
Sbjct: 391 -------HLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVK--PNTAHTFII- 440
Query: 568 LLENADDREATYMLKASSQSEMKRWM 593
R+ + L+ ++ E K W+
Sbjct: 441 -----TGRKRSLELQTRTEEEKKEWI 461
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 84.0 bits (206), Expect = 5e-16
Identities = 90/386 (23%), Positives = 171/386 (44%), Gaps = 51/386 (13%)
Query: 214 TPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIK 273
TP+EE + + EEP S + PQ + +G+ + P+ K
Sbjct: 121 TPQEEADSDVGEEPDS----ENTPQ-----------------KADKDAGLAQHSGPQ--K 157
Query: 274 LQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHI-LFSNVLDVLAVSERFL 332
L EL+ +E +Y K L+LL F R+ P E + +FSN+ + +FL
Sbjct: 158 LLHIAQELLHTEETYVKRLHLLDQVFCT--RLTDAGIPPEVIMGIFSNISSIHRFHGQFL 215
Query: 333 L-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELI 391
L EL+ R+ E + + + A +Y YV N Q F++++
Sbjct: 216 LPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVV 275
Query: 392 AQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRV-EERSERECTALDAHKELEMV 450
++ C L ++ P QR+ R +LL+++ LKR+ ++ +R+ DA + LE++
Sbjct: 276 HSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK----DAERSLELI 331
Query: 451 VKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRT 510
A N + + E+M + + E I++ + L+K+G++Q++S + R
Sbjct: 332 STAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDR- 390
Query: 511 KKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILR 567
+LFLFN +++ C ++ G K+ V + L+V+++ A+ FI+
Sbjct: 391 -------HLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVK--PNTAHTFII- 440
Query: 568 LLENADDREATYMLKASSQSEMKRWM 593
R+ + L+ ++ E K W+
Sbjct: 441 -----TGRKRSLELQTRTEEEKKEWI 461
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 83.2 bits (204), Expect = 8e-16
Identities = 66/292 (22%), Positives = 138/292 (47%), Gaps = 37/292 (12%)
Query: 250 NLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKIL 309
++++D+ ++ +++ E+ K + E+ +EA YY++L + ++M +R +L
Sbjct: 170 DIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP--LRLVL 227
Query: 310 HPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSN 369
P++ +F N+ D++ V FL ++ + +V V+ + +Y Y S+
Sbjct: 228 SPADMAAVFINLEDLIKVHHSFLRAIDVSV---MVGGSTLAKVFLDFKERLLIYGEYCSH 284
Query: 370 QTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKR 429
+ + T QLL + FR+ + + L + L++P QR+ + LL++ +L
Sbjct: 285 MEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSH 344
Query: 430 VEERSERE--CTALDAHKELEMV---VKACNEGVRKMSRTEQMI-SIQKKMEFKIKSVPI 483
ER ER+ AL+A ++L M VK E +RK+S + I ++Q K+E
Sbjct: 345 SAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLE-------- 396
Query: 484 ISHSRWLLKQGELQQMSGPKTSRTLRTKKLFH----EIYLFLFNDLLVICRQ 531
+ PK L+ + + + + YLFLF+ ++++C++
Sbjct: 397 --------------EFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKR 434
Score = 32.0 bits (71), Expect = 2.0
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 607 FTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKT--DDGWIFGERLHDQERGWFP 664
FT R++ + + + A+ EL+L D++ I + D GW GE + GWFP
Sbjct: 774 FTPRVIGTAVAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET--NGRIGWFP 829
Query: 665 SSMTEE 670
S+ EE
Sbjct: 830 STYVEE 835
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 82.0 bits (201), Expect = 2e-15
Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%)
Query: 213 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 272
D+ EEE +E+E+E+ A CL + W++L + E L +
Sbjct: 297 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 335
Query: 273 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 329
QEA++EL+ +EASY + L ++++ F+ N + +L EA LFSN+ ++ +
Sbjct: 336 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 395
Query: 330 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 382
R +LE R + D ++ F YI Y + + LL+
Sbjct: 396 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 454
Query: 383 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 440
+ FR I E P+C+ L S L P QR+T+ LL++++L++ EE +E
Sbjct: 455 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 514
Query: 441 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 483
+ + + V AC ++ R ++S + K+ + PI
Sbjct: 515 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 574
Query: 484 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 539
S R LL +G L+ G + ++Y FLF DLL++ + + +
Sbjct: 575 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 625
Query: 540 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596
P + ++ EL D G F+L L Y +AS Q+ + W+ ++
Sbjct: 626 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 679
Score = 31.6 bits (70), Expect = 2.7
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%)
Query: 182 YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 226
Y ++ LQ++ R Q+ + ED EEEEEEEEEEE
Sbjct: 680 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 722
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 82.0 bits (201), Expect = 2e-15
Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%)
Query: 213 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 272
D+ EEE +E+E+E+ A CL + W++L + E L +
Sbjct: 374 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 412
Query: 273 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 329
QEA++EL+ +EASY + L ++++ F+ N + +L EA LFSN+ ++ +
Sbjct: 413 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 472
Query: 330 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 382
R +LE R + D ++ F YI Y + + LL+
Sbjct: 473 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 531
Query: 383 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 440
+ FR I E P+C+ L S L P QR+T+ LL++++L++ EE +E
Sbjct: 532 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 591
Query: 441 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 483
+ + + V AC ++ R ++S + K+ + PI
Sbjct: 592 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 651
Query: 484 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 539
S R LL +G L+ G + ++Y FLF DLL++ + + +
Sbjct: 652 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 702
Query: 540 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596
P + ++ EL D G F+L L Y +AS Q+ + W+ ++
Sbjct: 703 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 756
Score = 31.6 bits (70), Expect = 2.7
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%)
Query: 182 YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 226
Y ++ LQ++ R Q+ + ED EEEEEEEEEEE
Sbjct: 757 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 799
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 82.0 bits (201), Expect = 2e-15
Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%)
Query: 213 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 272
D+ EEE +E+E+E+ A CL + W++L + E L +
Sbjct: 297 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 335
Query: 273 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 329
QEA++EL+ +EASY + L ++++ F+ N + +L EA LFSN+ ++ +
Sbjct: 336 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 395
Query: 330 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 382
R +LE R + D ++ F YI Y + + LL+
Sbjct: 396 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 454
Query: 383 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 440
+ FR I E P+C+ L S L P QR+T+ LL++++L++ EE +E
Sbjct: 455 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 514
Query: 441 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 483
+ + + V AC ++ R ++S + K+ + PI
Sbjct: 515 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 574
Query: 484 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 539
S R LL +G L+ G + ++Y FLF DLL++ + + +
Sbjct: 575 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 625
Query: 540 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596
P + ++ EL D G F+L L Y +AS Q+ + W+ ++
Sbjct: 626 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 679
Score = 31.6 bits (70), Expect = 2.7
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%)
Query: 182 YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 226
Y ++ LQ++ R Q+ + ED EEEEEEEEEEE
Sbjct: 680 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 722
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 82.0 bits (201), Expect = 2e-15
Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%)
Query: 213 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 272
D+ EEE +E+E+E+ A CL + W++L + E L +
Sbjct: 297 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 335
Query: 273 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 329
QEA++EL+ +EASY + L ++++ F+ N + +L EA LFSN+ ++ +
Sbjct: 336 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 395
Query: 330 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 382
R +LE R + D ++ F YI Y + + LL+
Sbjct: 396 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 454
Query: 383 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 440
+ FR I E P+C+ L S L P QR+T+ LL++++L++ EE +E
Sbjct: 455 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 514
Query: 441 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 483
+ + + V AC ++ R ++S + K+ + PI
Sbjct: 515 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 574
Query: 484 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 539
S R LL +G L+ G + ++Y FLF DLL++ + + +
Sbjct: 575 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 625
Query: 540 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596
P + ++ EL D G F+L L Y +AS Q+ + W+ ++
Sbjct: 626 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 679
Score = 31.6 bits (70), Expect = 2.7
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%)
Query: 182 YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 226
Y ++ LQ++ R Q+ + ED EEEEEEEEEEE
Sbjct: 680 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 722
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 82.0 bits (201), Expect = 2e-15
Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 71/419 (16%)
Query: 213 DTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEI 272
D+ EEE +E+E+E+ A CL + W++L + E L +
Sbjct: 353 DSWEEEYDEDEDEDNA-----------CLRLE-----DSWRELIDGH-----EKLTRRQC 391
Query: 273 KLQEAMFELVTSEASYYKSLNLLVSHFM---ENERIRKILHPSEAHILFSNVLDVLAVSE 329
QEA++EL+ +EASY + L ++++ F+ N + +L EA LFSN+ ++ +
Sbjct: 392 HQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHR 451
Query: 330 RF-------LLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 382
R +LE R + D ++ F YI Y + + LL+
Sbjct: 452 RLWASVMAPVLEKARRTRALLQPGDFLK-GFKMFGSLFKPYIRYCMEEEGCMEYMRGLLR 510
Query: 383 EKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTA-- 440
+ FR I E P+C+ L S L P QR+T+ LL++++L++ EE +E
Sbjct: 511 DNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAM 570
Query: 441 LDAHKELEMVVKACNEGVRKMSRTEQMIS-----------------IQKKMEFKIKSVPI 483
+ + + V AC ++ R ++S + K+ + PI
Sbjct: 571 IGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPI 630
Query: 484 ISHS----RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQV 539
S R LL +G L+ G + ++Y FLF DLL++ + + +
Sbjct: 631 PGASPEETRQLLLEGSLRMKEGKDSKM---------DVYCFLFTDLLLVTKAVKKAERTR 681
Query: 540 FDSAPRGLLRV--EELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596
P + ++ EL D G F+L L Y +AS Q+ + W+ ++
Sbjct: 682 VIRPPLLVDKIVCRELRDPGS-----FLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 735
Score = 31.6 bits (70), Expect = 2.7
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%)
Query: 182 YRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEE 226
Y ++ LQ++ R Q+ + ED EEEEEEEEEEE
Sbjct: 736 YNAQNQLQQL--RAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEE 778
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 81.3 bits (199), Expect = 3e-15
Identities = 76/327 (23%), Positives = 147/327 (44%), Gaps = 38/327 (11%)
Query: 280 ELVTSEASYYKSLNLLVSHF----MENERIRKILHPSEAHILFSNVLDVLAVSERFLL-E 334
EL+ +E +Y L+LL F ++ R K ++FSN+ + +F L E
Sbjct: 109 ELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPE 168
Query: 335 LEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQL 394
L+ R+++ + D++ + A +Y YV N + F+E++ ++
Sbjct: 169 LQRRLDDWTANPRIGDVIQKLAP-FLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRI 227
Query: 395 ELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKAC 454
+ L ++ P QRI R +LL++ ++++ ++ + DA K L+M+ A
Sbjct: 228 QSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQA---DAQKALDMIFSAA 284
Query: 455 ---NEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTK 511
N + +M R + + + +++ + I+ S LL++G + ++S +
Sbjct: 285 QHSNAAITEMERLQDLWEVYQRLGLE---DDIVDPSNTLLREGPVLKISFRRNDPM---- 337
Query: 512 KLFHEIYLFLFNDLLVICRQIP-----GDKYQVFDSAPRGLLRVEELEDQGQTLANVFIL 566
E YLFLFN++L+ C +P G ++QV ++V EL D + F++
Sbjct: 338 ----ERYLFLFNNMLLYC--VPRVIQVGAQFQVRTRIDVAGMKVRELMD--AEFPHSFLV 389
Query: 567 RLLENADDREATYMLKASSQSEMKRWM 593
++ T L+A SQ EM WM
Sbjct: 390 ------SGKQRTLELQARSQEEMISWM 410
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 79.7 bits (195), Expect = 9e-15
Identities = 65/276 (23%), Positives = 129/276 (46%), Gaps = 16/276 (5%)
Query: 267 LQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLA 326
L EI QE + EL +EAS+ ++L +L F + + ++ E LF N+ +++
Sbjct: 768 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 827
Query: 327 VSERFLLELEHRMEENIVISDVCDIVYRY-----AADHFSVYITYVSNQTYQERTYKQLL 381
+ + ++ EE +I ++ D++ + V + S Q+ K
Sbjct: 828 IHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQ 887
Query: 382 QEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVE---ERSEREC 438
++++ F+ + + E P+CR L +I QR+T+ LL+++I+K E E+ C
Sbjct: 888 RKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLC 947
Query: 439 TALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKME---FKIKSVPIISHSRWLLKQGE 495
A D +E ++K NE V++ ++ QK+++ + S P+ + + L
Sbjct: 948 RARDQCRE---ILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTR 1004
Query: 496 LQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQ 531
GP T R + K L ++++ L DLLV+ ++
Sbjct: 1005 KMIHEGPLTWRISKDKTL--DLHVLLLEDLLVLLQK 1038
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 79.7 bits (195), Expect = 9e-15
Identities = 65/276 (23%), Positives = 129/276 (46%), Gaps = 16/276 (5%)
Query: 267 LQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLA 326
L EI QE + EL +EAS+ ++L +L F + + ++ E LF N+ +++
Sbjct: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 787
Query: 327 VSERFLLELEHRMEENIVISDVCDIVYRY-----AADHFSVYITYVSNQTYQERTYKQLL 381
+ + ++ EE +I ++ D++ + V + S Q+ K
Sbjct: 788 IHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQ 847
Query: 382 QEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVE---ERSEREC 438
++++ F+ + + E P+CR L +I QR+T+ LL+++I+K E E+ C
Sbjct: 848 RKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLC 907
Query: 439 TALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKME---FKIKSVPIISHSRWLLKQGE 495
A D +E ++K NE V++ ++ QK+++ + S P+ + + L
Sbjct: 908 RARDQCRE---ILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTR 964
Query: 496 LQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQ 531
GP T R + K L ++++ L DLLV+ ++
Sbjct: 965 KMIHEGPLTWRISKDKTL--DLHVLLLEDLLVLLQK 998
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 79.7 bits (195), Expect = 9e-15
Identities = 96/416 (23%), Positives = 179/416 (43%), Gaps = 32/416 (7%)
Query: 200 EIEDNTNGSPASEDT--PEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPE 257
E+ D++ P S ++ P E +E E E P + + L P W++L
Sbjct: 360 ELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPG-WRELVP 418
Query: 258 IRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHIL 317
L L ++K QE + EL+ +EA++ + L +L F + E +
Sbjct: 419 ---PDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNI 475
Query: 318 FSNVLDVLAVSERFLLEL-EHRMEENIVISDVCDIVY-RYAADHFS----VYITYVSNQT 371
F ++ +++ V FL L + R E +I ++ D++ R+ S + + S Q+
Sbjct: 476 FPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQS 535
Query: 372 YQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVE 431
+ K ++ F + + E P+CR L + QR+T+ LL+Q+I + E
Sbjct: 536 FALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTE 595
Query: 432 ERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKME---FKIKSVPIISHSR 488
E +ERE L A E ++ N+ VR M ++ Q++++ + S P++S +
Sbjct: 596 EPTEREKVELAAECCRE-ILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFK 654
Query: 489 WLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLL 548
L + GP T R + K + E+++ L +DLL++ ++ D+ + S R L
Sbjct: 655 NLDITKKKLVHEGPLTWRVTKDKAV--EVHVLLLDDLLLLLQR--QDERLLLKSHSRTLT 710
Query: 549 RVEELEDQGQTLANVFILRLLENADDREATYM------------LKASSQSEMKRW 592
+ + + + + E A D +A Y+ L A + SE K W
Sbjct: 711 PTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNW 766
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 79.7 bits (195), Expect = 9e-15
Identities = 96/416 (23%), Positives = 179/416 (43%), Gaps = 32/416 (7%)
Query: 200 EIEDNTNGSPASEDT--PEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPE 257
E+ D++ P S ++ P E +E E E P + + L P W++L
Sbjct: 312 ELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPG-WRELVP 370
Query: 258 IRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHIL 317
L L ++K QE + EL+ +EA++ + L +L F + E +
Sbjct: 371 ---PDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNI 427
Query: 318 FSNVLDVLAVSERFLLEL-EHRMEENIVISDVCDIVY-RYAADHFS----VYITYVSNQT 371
F ++ +++ V FL L + R E +I ++ D++ R+ S + + S Q+
Sbjct: 428 FPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQS 487
Query: 372 YQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVE 431
+ K ++ F + + E P+CR L + QR+T+ LL+Q+I + E
Sbjct: 488 FALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTE 547
Query: 432 ERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKME---FKIKSVPIISHSR 488
E +ERE L A E ++ N+ VR M ++ Q++++ + S P++S +
Sbjct: 548 EPTEREKVELAAECCRE-ILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFK 606
Query: 489 WLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLL 548
L + GP T R + K + E+++ L +DLL++ ++ D+ + S R L
Sbjct: 607 NLDITKKKLVHEGPLTWRVTKDKAV--EVHVLLLDDLLLLLQR--QDERLLLKSHSRTLT 662
Query: 549 RVEELEDQGQTLANVFILRLLENADDREATYM------------LKASSQSEMKRW 592
+ + + + + E A D +A Y+ L A + SE K W
Sbjct: 663 PTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNW 718
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 79.7 bits (195), Expect = 9e-15
Identities = 96/416 (23%), Positives = 179/416 (43%), Gaps = 32/416 (7%)
Query: 200 EIEDNTNGSPASEDT--PEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPE 257
E+ D++ P S ++ P E +E E E P + + L P W++L
Sbjct: 345 ELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPG-WRELVP 403
Query: 258 IRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHIL 317
L L ++K QE + EL+ +EA++ + L +L F + E +
Sbjct: 404 ---PDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNI 460
Query: 318 FSNVLDVLAVSERFLLEL-EHRMEENIVISDVCDIVY-RYAADHFS----VYITYVSNQT 371
F ++ +++ V FL L + R E +I ++ D++ R+ S + + S Q+
Sbjct: 461 FPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQS 520
Query: 372 YQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVE 431
+ K ++ F + + E P+CR L + QR+T+ LL+Q+I + E
Sbjct: 521 FALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTE 580
Query: 432 ERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKME---FKIKSVPIISHSR 488
E +ERE L A E ++ N+ VR M ++ Q++++ + S P++S +
Sbjct: 581 EPTEREKVELAAECCRE-ILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFK 639
Query: 489 WLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLL 548
L + GP T R + K + E+++ L +DLL++ ++ D+ + S R L
Sbjct: 640 NLDITKKKLVHEGPLTWRVTKDKAV--EVHVLLLDDLLLLLQR--QDERLLLKSHSRTLT 695
Query: 549 RVEELEDQGQTLANVFILRLLENADDREATYM------------LKASSQSEMKRW 592
+ + + + + E A D +A Y+ L A + SE K W
Sbjct: 696 PTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNW 751
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 79.7 bits (195), Expect = 9e-15
Identities = 65/272 (23%), Positives = 127/272 (46%), Gaps = 37/272 (13%)
Query: 270 EEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSE 329
E+ K + E+ +EA YY++L + ++M +R +L P++ +F N+ D++ V
Sbjct: 195 EDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP--LRLVLSPADMAAVFINLEDLIKVHH 252
Query: 330 RFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRE 389
FL ++ + +V V+ + +Y Y S+ + + T QLL + FR+
Sbjct: 253 SFLRAIDVSV---MVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 309
Query: 390 LIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERE--CTALDAHKEL 447
+ + L + L++P QR+ + LL++ +L ER ER+ AL+A ++L
Sbjct: 310 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDL 369
Query: 448 EMV---VKACNEGVRKMSRTEQMI-SIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPK 503
M VK E +RK+S + I ++Q K+E + PK
Sbjct: 370 AMYINEVKRDKETLRKISEFQSSIENLQVKLE----------------------EFGRPK 407
Query: 504 TSRTLRTKKLFH----EIYLFLFNDLLVICRQ 531
L+ + + + + YLFLF+ ++++C++
Sbjct: 408 IDGELKVRSIVNHTKQDRYLFLFDKVVIVCKR 439
Score = 32.0 bits (71), Expect = 2.0
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 607 FTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKT--DDGWIFGERLHDQERGWFP 664
FT R++ + + + A+ EL+L D++ I + D GW GE + GWFP
Sbjct: 813 FTPRVIGTAVAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET--NGRIGWFP 868
Query: 665 SSMTEE 670
S+ EE
Sbjct: 869 STYVEE 874
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 72.4 bits (176), Expect = 1e-12
Identities = 81/354 (22%), Positives = 140/354 (39%), Gaps = 45/354 (12%)
Query: 280 ELVTSEASYYKSLNLLVSHFMENER------IRKILHPSEAHILFSNVLDVLAVSERFLL 333
E++ +E Y +L L S F+ R + K L +LFSN+ D+L V + FL
Sbjct: 56 EILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLA 115
Query: 334 ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQ 393
LE+ + V+ D F VY Y SN R +L + L++
Sbjct: 116 ALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSC 175
Query: 394 LEL-DPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVK 452
+ L K +P +L+ P QRI + LL++ + KR + A + ++ V
Sbjct: 176 MLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCS 235
Query: 453 ACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKK 512
NE R+M + E + +Q +E + + LL QG L ++S
Sbjct: 236 NINETKRQMEKLEALEQLQSHIE-GWEGSNLTDICTQLLLQGTLLKISAGN--------- 285
Query: 513 LFHEIYLFLFNDLLVICRQ----------------IPGDKYQVFDSAPRGLLRVEELED- 555
E FLF++LLV C++ I G Y ++ VE +ED
Sbjct: 286 -IQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG 344
Query: 556 ------QGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTK 603
G T+ N + + + + ++ A + E ++W+ ++ R +
Sbjct: 345 TADYHSNGYTVTNGWKI----HNTAKNKWFVCMAKTAEEKQKWLDAIIREREQR 394
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 72.4 bits (176), Expect = 1e-12
Identities = 63/259 (24%), Positives = 111/259 (42%), Gaps = 18/259 (6%)
Query: 280 ELVTSEASYYKSLNLLVSHFMEN------ERIRKILHPSEAHILFSNVLDVLAVSERFLL 333
EL +E Y +L LVS F+ ++ K + +LFSN+ D+LAV + FL
Sbjct: 30 ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89
Query: 334 ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQ 393
+E + + + D F +Y Y SN ++ +L + + L+
Sbjct: 90 VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149
Query: 394 LELDP-KCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVK 452
+ L K +P +L+ P QRI + L+++ +LKR + ++A + ++ V
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209
Query: 453 ACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKK 512
NE R+M + E + Q +E + I +L G L ++S
Sbjct: 210 NINEAKRQMEKLEVLEEWQSHIE-GWEGSNITDTCTEMLMCGVLLKISSGN--------- 259
Query: 513 LFHEIYLFLFNDLLVICRQ 531
E FLF++LLV C++
Sbjct: 260 -IQERVFFLFDNLLVYCKR 277
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,017,054
Number of Sequences: 37866
Number of extensions: 1371988
Number of successful extensions: 20695
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 311
Number of HSP's successfully gapped in prelim test: 304
Number of HSP's that attempted gapping in prelim test: 14524
Number of HSP's gapped (non-prelim): 3801
length of query: 710
length of database: 18,247,518
effective HSP length: 109
effective length of query: 601
effective length of database: 14,120,124
effective search space: 8486194524
effective search space used: 8486194524
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.