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Search of human proteins with 149363700
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149363700 syntaxin binding protein 5-like [Homo sapiens]
(1186 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149363700 syntaxin binding protein 5-like [Homo sapiens] 2407 0.0
gi|189217915 syntaxin binding protein 5 (tomosyn) isoform b [Hom... 1563 0.0
gi|189217897 syntaxin binding protein 5 (tomosyn) isoform a [Hom... 1555 0.0
gi|62912476 lethal giant larvae homolog 1 [Homo sapiens] 327 3e-89
gi|73427803 lethal giant larvae homolog 2 isoform c [Homo sapiens] 327 5e-89
gi|62739161 lethal giant larvae homolog 2 isoform a [Homo sapiens] 327 5e-89
gi|62739163 lethal giant larvae homolog 2 isoform b [Homo sapiens] 170 8e-42
gi|21426793 amisyn [Homo sapiens] 50 1e-05
gi|17402902 guanine nucleotide binding protein beta-subunit-like... 46 2e-04
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 43 0.002
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 42 0.003
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 42 0.003
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 42 0.003
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 42 0.003
gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens] 42 0.005
gi|19913367 transducin beta-like 1Y [Homo sapiens] 41 0.006
gi|19913365 transducin beta-like 1Y [Homo sapiens] 41 0.006
gi|15150805 transducin beta-like 1Y [Homo sapiens] 41 0.006
gi|157739942 gemin 5 [Homo sapiens] 40 0.010
gi|78482617 general transcription factor IIIC, polypeptide 2, be... 40 0.013
gi|4504205 general transcription factor IIIC, polypeptide 2, bet... 40 0.013
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 40 0.017
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 40 0.017
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 39 0.023
gi|34996489 pleckstrin homology domain interacting protein [Homo... 38 0.066
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 38 0.066
gi|89886480 zinedin isoform 2 [Homo sapiens] 37 0.086
gi|89886477 zinedin isoform 1 [Homo sapiens] 37 0.086
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 37 0.086
gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform ... 37 0.086
>gi|149363700 syntaxin binding protein 5-like [Homo sapiens]
Length = 1186
Score = 2407 bits (6239), Expect = 0.0
Identities = 1186/1186 (100%), Positives = 1186/1186 (100%)
Query: 1 MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQ 60
MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQ
Sbjct: 1 MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQ 60
Query: 61 ICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFL 120
ICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFL
Sbjct: 61 ICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFL 120
Query: 121 INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTH 180
INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTH
Sbjct: 121 INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTH 180
Query: 181 IVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKS 240
IVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKS
Sbjct: 181 IVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKS 240
Query: 241 KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGR 300
KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGR
Sbjct: 241 KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGR 300
Query: 301 KSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEF 360
KSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEF
Sbjct: 301 KSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEF 360
Query: 361 LTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFAD 420
LTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFAD
Sbjct: 361 LTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFAD 420
Query: 421 CPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASA 480
CPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASA
Sbjct: 421 CPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASA 480
Query: 481 ITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVII 540
ITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVII
Sbjct: 481 ITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVII 540
Query: 541 YKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASE 600
YKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASE
Sbjct: 541 YKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASE 600
Query: 601 GVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCN 660
GVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCN
Sbjct: 601 GVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCN 660
Query: 661 GLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTK 720
GLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTK
Sbjct: 661 GLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTK 720
Query: 721 RIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNR 780
RIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNR
Sbjct: 721 RIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNR 780
Query: 781 WGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDS 840
WGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDS
Sbjct: 781 WGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDS 840
Query: 841 FARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLKGAVLTFS 900
FARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLKGAVLTFS
Sbjct: 841 FARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLKGAVLTFS 900
Query: 901 CMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKV 960
CMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKV
Sbjct: 901 CMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKV 960
Query: 961 FSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPSLRPMLDVNYL 1020
FSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPSLRPMLDVNYL
Sbjct: 961 FSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPSLRPMLDVNYL 1020
Query: 1021 PLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNR 1080
PLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNR
Sbjct: 1021 PLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNR 1080
Query: 1081 GFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRAR 1140
GFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRAR
Sbjct: 1081 GFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRAR 1140
Query: 1141 IALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF 1186
IALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF
Sbjct: 1141 IALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF 1186
>gi|189217915 syntaxin binding protein 5 (tomosyn) isoform b [Homo
sapiens]
Length = 1151
Score = 1563 bits (4047), Expect = 0.0
Identities = 771/1206 (63%), Positives = 946/1206 (78%), Gaps = 75/1206 (6%)
Query: 1 MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQ 60
M+KFN RKVLDGLTA GSSS S HP G EIQETL SE+FQ
Sbjct: 1 MRKFNIRKVLDGLTA-----GSSSASQQ-----QQQQHPPGNR---EPEIQETLQSEHFQ 47
Query: 61 ICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFL 120
+CKTVRHGFP+QP+ALAFDPVQKILA+GT+TGA+R+ GRPGV+CYCQH+SGAAV+QLQFL
Sbjct: 48 LCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFL 107
Query: 121 INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTH 180
INEGALVSA +DDTLHLWNLRQKRPAILHSLKF RER+T+CHLPFQSKWLYVGTERGN H
Sbjct: 108 INEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIH 167
Query: 181 IVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKS 240
IVN+ESF LSGYVIMWNKAIELS+K+HPGPVVH+SD+P DEGKLLIG+E+GTVV WDLKS
Sbjct: 168 IVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKS 227
Query: 241 KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGR 300
K+A+ R YDEAIHS+ WHHEGKQF+CSHSDG+LT+WN++SP++P QT PHGK ++G+
Sbjct: 228 KKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGK 287
Query: 301 KSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEF 360
K E CKPILKVE+KT ++ EPFII SGGLSYD RRP LT+MHGK+ VLEMD+ IV+F
Sbjct: 288 KPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDF 347
Query: 361 LTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFAD 420
LTLCETPYPN+FQEPYAVVVLLEKDL+++DL Q+ +PIFENPYP+ IHESPVTC YFAD
Sbjct: 348 LTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFAD 407
Query: 421 CPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASA 480
CP DLI LYS+G + K+QGYS KEWPI+GG W LGAQ+YPEIIITGHADGS+KFWDASA
Sbjct: 408 CPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASA 467
Query: 481 ITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVII 540
ITLQ+LYKLKTSKVFEK + + + +IV+EDP+AIQ+I WCPESR+ C++GVSA+VII
Sbjct: 468 ITLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVII 527
Query: 541 YKFSRHEITTEIV-SLEVRLQYDVEDIITPEPETSPPFPDL---SAQLPSSRSLSGSTNT 596
Y+FS+ E+ TE++ LEVRL Y++ D+ TPE E PP P S P ST++
Sbjct: 528 YRFSKQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSS 587
Query: 597 VASEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAF 656
+S+G+ +D++PCL VK P++ PGYQ ELVIQLVWV GEPPQQITSLAV+S+YG+V F
Sbjct: 588 SSSDGL-RDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVF 646
Query: 657 GNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYP 716
GNCNG+A+VD++QK VLL++GTI+LY S+D Y+R+PRSPRK++Q
Sbjct: 647 GNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQ---------------- 690
Query: 717 DLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQ----------SCSS 766
S L ++++ V E +RCKSPTS + H + +
Sbjct: 691 -------PSGAGLCDISEGTVVPE-DRCKSPTSGSSSPHNSDDEQKMNNFIEKVKTKSRK 742
Query: 767 GKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEEN---RENSYNRSRSSSISS 823
++ + D++K++R ++SLP + + ++NS++RSRSSS++S
Sbjct: 743 FSKMVANDIAKMSR-----------------KLSLPTDLKPDLDVKDNSFSRSRSSSVTS 785
Query: 824 IDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMV 883
IDK+S+EAI+AL+F ++F RK DS+ SPCL+VGT+LG VL+I+LNLP EQR +PV+V
Sbjct: 786 IDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIV 845
Query: 884 LPSGTFLSLKGAVLTFSCMDRMGGLMQPPYEVWRD---PNNIDENEKSWRRKVVMNSSSA 940
PSGT L LKGA+L + +D G L+ P YE WR+ P DE EK +R+ V S S+
Sbjct: 846 SPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSS 905
Query: 941 SQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCAN 1000
SQEI ++QY +ICSEKQAKV SLP+Q C Y NITETSF+L+ ++V + +S CLACFCAN
Sbjct: 906 SQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLACFCAN 965
Query: 1001 GHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDN 1060
GHIM SLPSLRP+LDV YLPLT+MRIARTFCFTN GQALYLVSPTEIQRLTYSQE C+N
Sbjct: 966 GHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCEN 1025
Query: 1061 LQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPG 1120
LQ+MLG+LFTP+ETPEA NRGF KGLFGG Q+ DREELFGE+S+GKASRSLAQHIPGPG
Sbjct: 1026 LQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPG 1085
Query: 1121 SIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKD 1180
IEG+KGAA GV+GEL RAR+ALDERGQ+LG+LEE+TA M++SAE+FSKHAHE+MLKYKD
Sbjct: 1086 GIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYKD 1145
Query: 1181 KKWYQF 1186
KKWYQF
Sbjct: 1146 KKWYQF 1151
>gi|189217897 syntaxin binding protein 5 (tomosyn) isoform a [Homo
sapiens]
Length = 1115
Score = 1555 bits (4026), Expect = 0.0
Identities = 768/1193 (64%), Positives = 934/1193 (78%), Gaps = 85/1193 (7%)
Query: 1 MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQ 60
M+KFN RKVLDGLTA GSSS S HP G EIQETL SE+FQ
Sbjct: 1 MRKFNIRKVLDGLTA-----GSSSASQQ-----QQQQHPPGNR---EPEIQETLQSEHFQ 47
Query: 61 ICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFL 120
+CKTVRHGFP+QP+ALAFDPVQKILA+GT+TGA+R+ GRPGV+CYCQH+SGAAV+QLQFL
Sbjct: 48 LCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFL 107
Query: 121 INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTH 180
INEGALVSA +DDTLHLWNLRQKRPAILHSLKF RER+T+CHLPFQSKWLYVGTERGN H
Sbjct: 108 INEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIH 167
Query: 181 IVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKS 240
IVN+ESF LSGYVIMWNKAIELS+K+HPGPVVH+SD+P DEGKLLIG+E+GTVV WDLKS
Sbjct: 168 IVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKS 227
Query: 241 KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGR 300
K+A+ R YDEAIHS+ WHHEGKQF+CSHSDG+LT+WN++SP++P QT PHGK ++G+
Sbjct: 228 KKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGK 287
Query: 301 KSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEF 360
K E CKPILKVE+KT ++ EPFII SGGLSYD RRP LT+MHGK+ VLEMD+ IV+F
Sbjct: 288 KPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDF 347
Query: 361 LTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFAD 420
LTLCETPYPN+FQEPYAVVVLLEKDL+++DL Q+ +PIFENPYP+ IHESPVTC YFAD
Sbjct: 348 LTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFAD 407
Query: 421 CPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASA 480
CP DLI LYS+G + K+QGYS KEWPI+GG W LGAQ+YPEIIITGHADGS+KFWDASA
Sbjct: 408 CPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASA 467
Query: 481 ITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVII 540
ITLQ+LYKLKTSKVFEK + + + +IV+EDP+AIQ+I WCPESR+ C++GVSA+VII
Sbjct: 468 ITLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVII 527
Query: 541 YKFSRHEITTEIV-SLEVRLQYDVEDIITPEPETSPPFPDL---SAQLPSSRSLSGSTNT 596
Y+FS+ E+ TE++ LEVRL Y++ D+ TPE E PP P S P ST++
Sbjct: 528 YRFSKQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSS 587
Query: 597 VASEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAF 656
+S+G+ +D++PCL VK P++ PGYQ ELVIQLVWV GEPPQQITSLAV+S+YG+V F
Sbjct: 588 SSSDGL-RDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVF 646
Query: 657 GNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYP 716
GNCNG+A+VD++QK VLL++GTI+LY S+D Y+R+PRSPRK++Q
Sbjct: 647 GNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQ---------------- 690
Query: 717 DLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVS 776
S L ++++ V E +RCKSPTS ++ + PT
Sbjct: 691 -------PSGAGLCDISEGTVVPE-DRCKSPTSAKMSRKLSLPTD--------------- 727
Query: 777 KVNRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALY 836
++ L V ++NS++RSRSSS++SIDK+S+EAI+AL+
Sbjct: 728 --------------------LKPDLDV-----KDNSFSRSRSSSVTSIDKESREAISALH 762
Query: 837 FMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLKGAV 896
F ++F RK DS+ SPCL+VGT+LG VL+I+LNLP EQR +PV+V PSGT L LKGA+
Sbjct: 763 FCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKGAI 822
Query: 897 LTFSCMDRMGGLMQPPYEVWRD---PNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIIC 953
L + +D G L+ P YE WR+ P DE EK +R+ V S S+SQEI ++QY +IC
Sbjct: 823 LRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVIC 882
Query: 954 SEKQAKVFSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPSLRP 1013
SEKQAKV SLP+Q C Y NITETSF+L+ ++V + +S CLACFCANGHIM SLPSLRP
Sbjct: 883 SEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRP 942
Query: 1014 MLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIE 1073
+LDV YLPLT+MRIARTFCFTN GQALYLVSPTEIQRLTYSQE C+NLQ+MLG+LFTP+E
Sbjct: 943 LLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVE 1002
Query: 1074 TPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVM 1133
TPEA NRGF KGLFGG Q+ DREELFGE+S+GKASRSLAQHIPGPG IEG+KGAA GV+
Sbjct: 1003 TPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVV 1062
Query: 1134 GELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF 1186
GEL RAR+ALDERGQ+LG+LEE+TA M++SAE+FSKHAHE+MLKYKDKKWYQF
Sbjct: 1063 GELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYKDKKWYQF 1115
>gi|62912476 lethal giant larvae homolog 1 [Homo sapiens]
Length = 1064
Score = 327 bits (839), Expect = 3e-89
Identities = 281/1051 (26%), Positives = 456/1051 (43%), Gaps = 174/1051 (16%)
Query: 51 QETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHES 110
+E L E F KTV HGFP+QP+ALAFDP +I+AIGTR+GA++I G PGV+ H
Sbjct: 15 REKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFTGLHRD 74
Query: 111 GAAVLQLQFLINEGALVSASSDDTLHLWNLRQ----------------KRPAILH-SLKF 153
A V Q+ FL +G L+S D +LHLW + RP S
Sbjct: 75 AATVTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGASAPL 134
Query: 154 NRERITYCHLPFQSKWLYVGTERGNTHIVNIESF-ILSGYVIMWNKAIELSTKTHP---- 208
+ R+T L +GTE + +++ + +L G + + + +
Sbjct: 135 SLTRVTVVLLVAAGDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKA 194
Query: 209 -GPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMC 267
GPV L RD K+LIGY G +V W+ S+ + ++ + S+ W + +
Sbjct: 195 LGPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGNQQLESLCWGRDSSTVVS 254
Query: 268 SHSDGSLTLWNLKSPS----RPFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFI 323
SHSDGS +W++ + S +P T P+G CK I K+ ++ C++ FI
Sbjct: 255 SHSDGSYAVWSVDAGSFPTLQPTVATTPYGPFP--------CKAINKILWRNCESGGHFI 306
Query: 324 IFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLE 383
IFSGG+ R ++++ + + L+ I++F T+ T +EF +P A+ VLLE
Sbjct: 307 IFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLLE 366
Query: 384 KDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSN 443
++L+V+DL +P PY +H S +TC+A+ A P L + S G + Q S+
Sbjct: 367 EELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVASVPAKLWARIVSAGEQQSPQPVSS 426
Query: 444 K-EWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGE 502
WPI+GG + +++TGH DG+++FWDAS + L+ LYKL T+ +F+
Sbjct: 427 ALSWPITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTD-CEH 485
Query: 503 GKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVS--AYVIIYKFSRHEITTEIVSLEVRLQ 560
+ E+D W P ++ C S + + K + + T ++V Q
Sbjct: 486 ADSLAQAAEDD--------WPPFRKVGCFDPYSDDPRLGVQKVALCKYTAQMVVAGTAGQ 537
Query: 561 YDVEDI--ITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPCLNVKTRPVR 618
V ++ + E S DL EG T L+ +T P+
Sbjct: 538 VLVLELSDVPVEQAVSVAIIDLLQD---------------REGFTWKGHERLSPRTGPLP 582
Query: 619 MPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGT 678
P G+Q +++Q + PP +T++ + + + +VAFG +G + D+ +K+ +L+ T
Sbjct: 583 WPAGFQPRVLVQCL-----PPAAVTAVTLHTEWSLVAFGTSHGFGLFDYQRKSPVLARCT 637
Query: 679 IDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVP 738
+ P D+ M G + L K +R S++ +
Sbjct: 638 L-----------HPN----------DSLAMEGPLSRVKSLKKSLRQSFRRI--------- 667
Query: 739 LELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSA--AC 796
+S SGK+ ++ SK+ AQ A AC
Sbjct: 668 ----------------------RKSRVSGKKRAANASSKLQE--------ANAQLAEQAC 697
Query: 797 MEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVG 856
+ +T + R RS S+S + + LYF D+F R + + P ++ G
Sbjct: 698 PH-DVEMTPVQRRIEP--RSADDSLSGV-------VRCLYFADTFLR-DGAHHGPTMWAG 746
Query: 857 TSLGMVLIISLNLPLA---DEQRFTEPV-MVLPSGTFLSLKGAVLTFSCMDRMGGLMQPP 912
T+ G V +L +P A E+R + V VL L + V+ + +D G + P
Sbjct: 747 TNSGSVFAYALEVPAAAVGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAVLDGRGRPLPEP 806
Query: 913 YEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTCLYVH 972
YE RD + A G H +I SE+Q KVF+LP +
Sbjct: 807 YEASRD------------------LAQAPDMQGGHA-VLIASEEQFKVFTLPKVSAKTKF 847
Query: 973 NITE------TSFILQANVVVMC---SSACLACFCANGHIMIMSLPSLRPMLDVNYLPLT 1023
+T L V C + CLAC G + + S+P LRP + + +
Sbjct: 848 KLTAHEGCRVRKVALATFASVACEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKE 907
Query: 1024 DMRIARTFCFTNEGQALYLVSPTEIQRLTYS 1054
D+ + FT GQ YL+SP+E +R + S
Sbjct: 908 DISGIASCVFTRHGQGFYLISPSEFERFSLS 938
>gi|73427803 lethal giant larvae homolog 2 isoform c [Homo sapiens]
Length = 1020
Score = 327 bits (837), Expect = 5e-89
Identities = 279/1055 (26%), Positives = 452/1055 (42%), Gaps = 188/1055 (17%)
Query: 48 EEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQ 107
+ ++E L + FQ KTV HGFPHQP+AL + P +ILAIGTR+GAI++ G PGV+
Sbjct: 10 DPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGL 69
Query: 108 HESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPA--ILHSLKF----------NR 155
H+ AV Q+ L + LV+ D++LHLW+L+ K A + F +
Sbjct: 70 HQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSA 129
Query: 156 ERITYCHLPFQS-KWLYVGTERGNTHIVNIESF------ILSGYVIMWNKAIELSTKTHP 208
+IT LP S + LY+GTE GN +V + +F +S ++ E +
Sbjct: 130 TQITVV-LPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVF 188
Query: 209 GPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCS 268
V L + PRD ++LIGY G VV WDL+ R + + +I W +G+ +
Sbjct: 189 EMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSC 248
Query: 269 HSDGSLTLWNLKSPSR---PFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIF 325
HSDGS W + S ++ P ++ +P+G CK I ++ + T + PF IF
Sbjct: 249 HSDGSYCQWPVSSEAQQPEPLRSLVPYGPFP--------CKAITRILWLTTRQGLPFTIF 300
Query: 326 SGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKD 385
GG+ R ++++H T + ++ F L E F +PYA+VVL E++
Sbjct: 301 QGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEE 360
Query: 386 LIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKE 445
L+V+DL + +P + PY +H S +TC+ + ++ P L + + G + +S E
Sbjct: 361 LVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAH-FSTME 419
Query: 446 WPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVF---------- 495
WPI GG A ++++TGH DG+++FWDAS + L++LYKL T +VF
Sbjct: 420 WPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENF 479
Query: 496 EKQKVGEGKQTCEIVEEDPFA------IQMIYWCPESRIFCVSGVSAYVIIYKFSRHEIT 549
Q E ++ DP++ IQ I+ C S V+G + V++ + +
Sbjct: 480 SAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAE 539
Query: 550 TEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPC 609
+ +E L D EG
Sbjct: 540 QAVEQVEADLLQD------------------------------------QEGYRWKGHER 563
Query: 610 LNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQ 669
L ++ PVR PG+Q +++Q +PP +TSLA+ S + +VAFG +G
Sbjct: 564 LAARSGPVRFEPGFQPFVLVQC-----QPPAVVTSLALHSEWRLVAFGTSHGF------- 611
Query: 670 KTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSL 729
G D + ++ + P +D + G + L K +R S+
Sbjct: 612 -------GLFDHQQRRQVFVKCTLHP-------SDQLALEGPLSRVKSLKKSLRQSF--- 654
Query: 730 TELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFR 789
+R+ + VS R G P
Sbjct: 655 --------------------------------------RRMRRSRVSSRKRHPAGPPGEA 676
Query: 790 KAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTI 849
+ SA L +N E + + + + S+ D + + LYF D++ K+ S
Sbjct: 677 QEGSAKAERPGL-----QNMELAPVQRKIEARSAEDSFTG-FVRTLYFADTYL-KDSSRH 729
Query: 850 SPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTF-LSLKGAVLTFSCMDRMGGL 908
P L+ GT+ G + SL +P A E+R EPV + L + V+ +D
Sbjct: 730 CPSLWAGTNGGTIYAFSLRVPPA-ERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVP 788
Query: 909 MQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTC 968
+ P EV D + + + G HQ ++ SE+Q KVF+LP +
Sbjct: 789 LPEPLEVAHDLSKSPDMQ------------------GSHQLLVV-SEEQFKVFTLPKVSA 829
Query: 969 LYVHNIT--ETSFILQANVVVMCSSAC-------LACFCANGHIMIMSLPSLRPMLDVNY 1019
+T E S + + +V S LA G I ++SLP L+P + +
Sbjct: 830 KLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSC 889
Query: 1020 LPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYS 1054
+ D+ + FT GQ YL+SP+E +R + S
Sbjct: 890 IRREDVSGIASCVFTKYGQGFYLISPSEFERFSLS 924
>gi|62739161 lethal giant larvae homolog 2 isoform a [Homo sapiens]
Length = 1015
Score = 327 bits (837), Expect = 5e-89
Identities = 279/1055 (26%), Positives = 452/1055 (42%), Gaps = 188/1055 (17%)
Query: 48 EEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQ 107
+ ++E L + FQ KTV HGFPHQP+AL + P +ILAIGTR+GAI++ G PGV+
Sbjct: 10 DPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGL 69
Query: 108 HESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPA--ILHSLKF----------NR 155
H+ AV Q+ L + LV+ D++LHLW+L+ K A + F +
Sbjct: 70 HQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSA 129
Query: 156 ERITYCHLPFQS-KWLYVGTERGNTHIVNIESF------ILSGYVIMWNKAIELSTKTHP 208
+IT LP S + LY+GTE GN +V + +F +S ++ E +
Sbjct: 130 TQITVV-LPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVF 188
Query: 209 GPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCS 268
V L + PRD ++LIGY G VV WDL+ R + + +I W +G+ +
Sbjct: 189 EMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSC 248
Query: 269 HSDGSLTLWNLKSPSR---PFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIF 325
HSDGS W + S ++ P ++ +P+G CK I ++ + T + PF IF
Sbjct: 249 HSDGSYCQWPVSSEAQQPEPLRSLVPYGPFP--------CKAITRILWLTTRQGLPFTIF 300
Query: 326 SGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKD 385
GG+ R ++++H T + ++ F L E F +PYA+VVL E++
Sbjct: 301 QGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEE 360
Query: 386 LIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKE 445
L+V+DL + +P + PY +H S +TC+ + ++ P L + + G + +S E
Sbjct: 361 LVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAH-FSTME 419
Query: 446 WPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVF---------- 495
WPI GG A ++++TGH DG+++FWDAS + L++LYKL T +VF
Sbjct: 420 WPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENF 479
Query: 496 EKQKVGEGKQTCEIVEEDPFA------IQMIYWCPESRIFCVSGVSAYVIIYKFSRHEIT 549
Q E ++ DP++ IQ I+ C S V+G + V++ + +
Sbjct: 480 SAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAE 539
Query: 550 TEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPC 609
+ +E L D EG
Sbjct: 540 QAVEQVEADLLQD------------------------------------QEGYRWKGHER 563
Query: 610 LNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQ 669
L ++ PVR PG+Q +++Q +PP +TSLA+ S + +VAFG +G
Sbjct: 564 LAARSGPVRFEPGFQPFVLVQC-----QPPAVVTSLALHSEWRLVAFGTSHGF------- 611
Query: 670 KTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSL 729
G D + ++ + P +D + G + L K +R S+
Sbjct: 612 -------GLFDHQQRRQVFVKCTLHP-------SDQLALEGPLSRVKSLKKSLRQSF--- 654
Query: 730 TELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFR 789
+R+ + VS R G P
Sbjct: 655 --------------------------------------RRMRRSRVSSRKRHPAGPPGEA 676
Query: 790 KAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTI 849
+ SA L +N E + + + + S+ D + + LYF D++ K+ S
Sbjct: 677 QEGSAKAERPGL-----QNMELAPVQRKIEARSAEDSFTG-FVRTLYFADTYL-KDSSRH 729
Query: 850 SPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTF-LSLKGAVLTFSCMDRMGGL 908
P L+ GT+ G + SL +P A E+R EPV + L + V+ +D
Sbjct: 730 CPSLWAGTNGGTIYAFSLRVPPA-ERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVP 788
Query: 909 MQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTC 968
+ P EV D + + + G HQ ++ SE+Q KVF+LP +
Sbjct: 789 LPEPLEVAHDLSKSPDMQ------------------GSHQLLVV-SEEQFKVFTLPKVSA 829
Query: 969 LYVHNIT--ETSFILQANVVVMCSSAC-------LACFCANGHIMIMSLPSLRPMLDVNY 1019
+T E S + + +V S LA G I ++SLP L+P + +
Sbjct: 830 KLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSC 889
Query: 1020 LPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYS 1054
+ D+ + FT GQ YL+SP+E +R + S
Sbjct: 890 IRREDVSGIASCVFTKYGQGFYLISPSEFERFSLS 924
>gi|62739163 lethal giant larvae homolog 2 isoform b [Homo sapiens]
Length = 356
Score = 170 bits (430), Expect = 8e-42
Identities = 108/340 (31%), Positives = 168/340 (49%), Gaps = 31/340 (9%)
Query: 48 EEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQ 107
+ ++E L + FQ KTV HGFPHQP+AL + P +ILAIGTR+GAI++ G PGV+
Sbjct: 10 DPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGL 69
Query: 108 HESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPA--ILHSLKF----------NR 155
H+ AV Q+ L + LV+ D++LHLW+L+ K A + F +
Sbjct: 70 HQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSA 129
Query: 156 ERITYCHLPFQS-KWLYVGTERGNTHIVNIESF------ILSGYVIMWNKAIELSTKTHP 208
+IT LP S + LY+GTE GN +V + +F +S ++ E +
Sbjct: 130 TQITVV-LPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVF 188
Query: 209 GPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCS 268
V L + PRD ++LIGY G VV WDL+ R + + +I W +G+ +
Sbjct: 189 EMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSC 248
Query: 269 HSDGSLTLWNLKSPSR---PFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIF 325
HSDGS W + S ++ P ++ +P+G CK I ++ + T + PF IF
Sbjct: 249 HSDGSYCQWPVSSEAQQPEPLRSLVPYGPF--------PCKAITRILWLTTRQGLPFTIF 300
Query: 326 SGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCE 365
GG+ R ++++H T + ++ F L E
Sbjct: 301 QGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTE 340
>gi|21426793 amisyn [Homo sapiens]
Length = 210
Score = 50.1 bits (118), Expect = 1e-05
Identities = 28/64 (43%), Positives = 40/64 (62%), Gaps = 2/64 (3%)
Query: 1116 IPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELM 1175
I G SI + AA V + +A AL+ERG+RLG EEKT + SA+ F++ AH+L
Sbjct: 148 IMGGNSI--LHSAADSVTSAVQKASQALNERGERLGRAEEKTEDLKNSAQQFAETAHKLA 205
Query: 1176 LKYK 1179
+K+K
Sbjct: 206 MKHK 209
>gi|17402902 guanine nucleotide binding protein beta-subunit-like
polypeptide [Homo sapiens]
Length = 327
Score = 46.2 bits (108), Expect = 2e-04
Identities = 49/205 (23%), Positives = 89/205 (43%), Gaps = 15/205 (7%)
Query: 84 ILAIGTRTGAIRILG---RPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNL 140
+L G+++G + I R V H G V LQ L L+S D L LW+L
Sbjct: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGH-GGQCVTWLQTLPQGRQLLSQGRDLKLCLWDL 97
Query: 141 RQKRPAILHSLKFNRERITYCHLPF----QSKWLYVGTERGNTHIVNIESFILSGYVIMW 196
+ R A++ S+ E + +C Q +W RG+ + +E + +
Sbjct: 98 AEGRSAVVDSVCL--ESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALK 155
Query: 197 NKAIELSTKTHPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLKSKRAELRV-YYDEAIH 254
KA K + L + LL+ GYE+G+VV WD+ ++ R+ ++E +
Sbjct: 156 PKA---DAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVM 212
Query: 255 SIDWHHEGKQFMCSHSDGSLTLWNL 279
+D+ + + + + +L +W+L
Sbjct: 213 DLDFDSQKARGISGSAGKALAVWSL 237
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 43.1 bits (100), Expect = 0.002
Identities = 38/149 (25%), Positives = 67/149 (44%), Gaps = 21/149 (14%)
Query: 121 INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTH 180
+N +V+ S D+T+H++++++K I H + C L F GN H
Sbjct: 50 VNSRFVVTGSKDETIHIYDMKKK---IEHGALVHHSGTITC-LKFY----------GNRH 95
Query: 181 IVNIESFILSGYVIMWN-KAIEL--STKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWD 237
++ S G + +W+ K E S K H G V LS P + L +G + T+ W+
Sbjct: 96 LI---SGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDK-TLRTWN 151
Query: 238 LKSKRAELRVYYDEAIHSIDWHHEGKQFM 266
L R+ + H ++W G+Q++
Sbjct: 152 LVEGRSAFIKNIKQNAHIVEWSPRGEQYV 180
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 42.4 bits (98), Expect = 0.003
Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 17/161 (10%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVG--TERGNTHIVN 183
L S S D TL +W+++Q+ +H L+ + + I + KW G T N++I+
Sbjct: 376 LASCSDDMTLKIWSMKQE--VCIHDLQAHNKEI------YTIKWSPTGPATSNPNSNIM- 426
Query: 184 IESFILSGYVIMWNKAIELSTKT---HPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLK 239
+ S V +W+ + T T H PV ++ SP +GK L G + V W+ +
Sbjct: 427 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--DGKYLASGSFDKCVHIWNTQ 484
Query: 240 SKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280
S I + W+ G + S SDGS+ + +L+
Sbjct: 485 SGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 42.4 bits (98), Expect = 0.003
Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 17/161 (10%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVG--TERGNTHIVN 183
L S S D TL +W+++Q+ +H L+ + + I + KW G T N++I+
Sbjct: 376 LASCSDDMTLKIWSMKQE--VCIHDLQAHNKEI------YTIKWSPTGPATSNPNSNIM- 426
Query: 184 IESFILSGYVIMWNKAIELSTKT---HPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLK 239
+ S V +W+ + T T H PV ++ SP +GK L G + V W+ +
Sbjct: 427 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--DGKYLASGSFDKCVHIWNTQ 484
Query: 240 SKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280
S I + W+ G + S SDGS+ + +L+
Sbjct: 485 SGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 42.4 bits (98), Expect = 0.003
Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 17/161 (10%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVG--TERGNTHIVN 183
L S S D TL +W+++Q+ +H L+ + + I + KW G T N++I+
Sbjct: 427 LASCSDDMTLKIWSMKQE--VCIHDLQAHNKEI------YTIKWSPTGPATSNPNSNIM- 477
Query: 184 IESFILSGYVIMWNKAIELSTKT---HPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLK 239
+ S V +W+ + T T H PV ++ SP +GK L G + V W+ +
Sbjct: 478 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--DGKYLASGSFDKCVHIWNTQ 535
Query: 240 SKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280
S I + W+ G + S SDGS+ + +L+
Sbjct: 536 SGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 42.4 bits (98), Expect = 0.003
Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 17/161 (10%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVG--TERGNTHIVN 183
L S S D TL +W+++Q+ +H L+ + + I + KW G T N++I+
Sbjct: 427 LASCSDDMTLKIWSMKQE--VCIHDLQAHNKEI------YTIKWSPTGPATSNPNSNIM- 477
Query: 184 IESFILSGYVIMWNKAIELSTKT---HPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLK 239
+ S V +W+ + T T H PV ++ SP +GK L G + V W+ +
Sbjct: 478 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--DGKYLASGSFDKCVHIWNTQ 535
Query: 240 SKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280
S I + W+ G + S SDGS+ + +L+
Sbjct: 536 SGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
>gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens]
Length = 400
Score = 41.6 bits (96), Expect = 0.005
Identities = 51/242 (21%), Positives = 97/242 (40%), Gaps = 50/242 (20%)
Query: 60 QICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIR--ILGR-----PGVDCYCQHESGA 112
Q +V H P + ++F+P + L+IG G I IL V Y H+S
Sbjct: 58 QYWPSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRV 117
Query: 113 A----VLQLQFLINEGALVSASSDDTLHLWNLRQ--------KRPAILHSLKFNRERITY 160
VL+L+++++ G D W+ + + A+ L+F+ E
Sbjct: 118 TMILFVLELEWVLSTG-------QDKQFAWHCSESGQRLGGYRTSAVASGLQFDVE---- 166
Query: 161 CHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRD 220
++ +++G G I+ +E N + + + H G V L P
Sbjct: 167 ------TRHVFIGDHSGQVTILKLE---------QENCTLVTTFRGHTGGVTALCWDP-V 210
Query: 221 EGKLLIGYENGTVVFWDL---KSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLW 277
+ L G + +V+ WD+ K EL+ + D + ++ + +Q + DG + +W
Sbjct: 211 QRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDR-VQALSYAQHTRQLISCGGDGGIVVW 269
Query: 278 NL 279
N+
Sbjct: 270 NM 271
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 41.2 bits (95), Expect = 0.006
Identities = 42/159 (26%), Positives = 69/159 (43%), Gaps = 15/159 (9%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHI-VNI 184
L S S D TL +W+++Q A +H L+ + + I + KW G N + + +
Sbjct: 374 LASCSDDMTLKIWSMKQD--ACVHDLQAHSKEI------YTIKWSPTGPATSNPNSSIML 425
Query: 185 ESFILSGYVIMWNKAIELSTKT---HPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLKS 240
S V +W+ + T T H PV ++ SP +GK L G + V W+ +S
Sbjct: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--DGKYLASGSFDKYVHIWNTQS 483
Query: 241 KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNL 279
I + W+ G + S SDGS+ + +L
Sbjct: 484 GSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 41.2 bits (95), Expect = 0.006
Identities = 42/159 (26%), Positives = 69/159 (43%), Gaps = 15/159 (9%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHI-VNI 184
L S S D TL +W+++Q A +H L+ + + I + KW G N + + +
Sbjct: 374 LASCSDDMTLKIWSMKQD--ACVHDLQAHSKEI------YTIKWSPTGPATSNPNSSIML 425
Query: 185 ESFILSGYVIMWNKAIELSTKT---HPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLKS 240
S V +W+ + T T H PV ++ SP +GK L G + V W+ +S
Sbjct: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--DGKYLASGSFDKYVHIWNTQS 483
Query: 241 KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNL 279
I + W+ G + S SDGS+ + +L
Sbjct: 484 GSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 41.2 bits (95), Expect = 0.006
Identities = 42/159 (26%), Positives = 69/159 (43%), Gaps = 15/159 (9%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHI-VNI 184
L S S D TL +W+++Q A +H L+ + + I + KW G N + + +
Sbjct: 374 LASCSDDMTLKIWSMKQD--ACVHDLQAHSKEI------YTIKWSPTGPATSNPNSSIML 425
Query: 185 ESFILSGYVIMWNKAIELSTKT---HPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLKS 240
S V +W+ + T T H PV ++ SP +GK L G + V W+ +S
Sbjct: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--DGKYLASGSFDKYVHIWNTQS 483
Query: 241 KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNL 279
I + W+ G + S SDGS+ + +L
Sbjct: 484 GSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|157739942 gemin 5 [Homo sapiens]
Length = 1508
Score = 40.4 bits (93), Expect = 0.010
Identities = 38/137 (27%), Positives = 61/137 (44%), Gaps = 18/137 (13%)
Query: 126 LVSASSDD-TLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYV-GTERGNTHIVN 183
L + SSDD T+ +W++ K H+L ++ I+ H + K L V G E+G
Sbjct: 81 LCATSSDDGTVKIWDVETKTVVTEHAL--HQHTISTLHWSPRVKDLIVSGDEKGVV---- 134
Query: 184 IESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRA 243
+ +N+ P + L+ SP E + IGY++G VV D+ K
Sbjct: 135 --------FCYWFNRNDSQHLFIEPRTIFCLTCSPHHEDLVAIGYKDGIVVIIDISKKGE 186
Query: 244 ELRVY--YDEAIHSIDW 258
+ +D+ IHSI W
Sbjct: 187 VIHRLRGHDDEIHSIAW 203
Score = 33.1 bits (74), Expect = 1.6
Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 14/118 (11%)
Query: 189 LSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLL-IGYENGTVVFWDLKSKRAELRV 247
LSG NK I + VH S + +GK++ +G E+G++ + + + + +
Sbjct: 515 LSGEAFDINKLIRDTNSIKYKLPVHTEISWKADGKIMALGNEDGSIEIFQIPNLKLICTI 574
Query: 248 Y-YDEAIHSIDWHHE-GKQ-----FMCSHSDGS-LTLWNLK-----SPSRPFQTTIPH 292
+ + +++I WHHE G Q M S S+ + + + NLK SP P T P+
Sbjct: 575 QQHHKLVNTISWHHEHGSQPELSYLMASGSNNAVIYVHNLKTVIESSPESPVTITEPY 632
>gi|78482617 general transcription factor IIIC, polypeptide 2, beta
110kDa [Homo sapiens]
Length = 911
Score = 40.0 bits (92), Expect = 0.013
Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 17/87 (19%)
Query: 219 RDEGKLLIGYENGTVVFWDLKSKR---------AELRVY-------YDEAIHSIDWHHEG 262
R L GY NG VVFW+L + L++Y +D+A+ ++ W
Sbjct: 566 RPHQHLAAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKAN 625
Query: 263 KQFMCS-HSDGSLTLWNLKSPSRPFQT 288
F+ S SD + W+L+ P P +
Sbjct: 626 SHFLVSAGSDRKIKFWDLRRPYEPINS 652
>gi|4504205 general transcription factor IIIC, polypeptide 2, beta
110kDa [Homo sapiens]
Length = 911
Score = 40.0 bits (92), Expect = 0.013
Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 17/87 (19%)
Query: 219 RDEGKLLIGYENGTVVFWDLKSKR---------AELRVY-------YDEAIHSIDWHHEG 262
R L GY NG VVFW+L + L++Y +D+A+ ++ W
Sbjct: 566 RPHQHLAAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKAN 625
Query: 263 KQFMCS-HSDGSLTLWNLKSPSRPFQT 288
F+ S SD + W+L+ P P +
Sbjct: 626 SHFLVSAGSDRKIKFWDLRRPYEPINS 652
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 39.7 bits (91), Expect = 0.017
Identities = 35/163 (21%), Positives = 69/163 (42%), Gaps = 34/163 (20%)
Query: 126 LVSASSDDTLHLWN-LRQKRP--------AILHSLKFNRERITYCHLPFQSKWLYVGTER 176
LVS S D TL LW+ K+P A+++ + F+ + F K + + R
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFD-KSIKLWDGR 110
Query: 177 GNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFW 236
++ ++ + + Y I W+ D L+ G + T+ W
Sbjct: 111 TGKYLASLRGHVAAVYQIAWSA---------------------DSRLLVSGSSDSTLKVW 149
Query: 237 DLKSKRA--ELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLW 277
D+K+++ +L + DE ++++DW +G++ D L +W
Sbjct: 150 DVKAQKLAMDLPGHADE-VYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 33.5 bits (75), Expect = 1.2
Identities = 22/71 (30%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 78 FDPVQKILAIGTRTGAIRIL-GRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLH 136
F P +I+A + +I++ GR G AAV Q+ + + LVS SSD TL
Sbjct: 88 FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 147
Query: 137 LWNLRQKRPAI 147
+W+++ ++ A+
Sbjct: 148 VWDVKAQKLAM 158
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 39.7 bits (91), Expect = 0.017
Identities = 35/163 (21%), Positives = 69/163 (42%), Gaps = 34/163 (20%)
Query: 126 LVSASSDDTLHLWN-LRQKRP--------AILHSLKFNRERITYCHLPFQSKWLYVGTER 176
LVS S D TL LW+ K+P A+++ + F+ + F K + + R
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFD-KSIKLWDGR 402
Query: 177 GNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFW 236
++ ++ + + Y I W+ D L+ G + T+ W
Sbjct: 403 TGKYLASLRGHVAAVYQIAWSA---------------------DSRLLVSGSSDSTLKVW 441
Query: 237 DLKSKRA--ELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLW 277
D+K+++ +L + DE ++++DW +G++ D L +W
Sbjct: 442 DVKAQKLAMDLPGHADE-VYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 34.3 bits (77), Expect = 0.72
Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 4/94 (4%)
Query: 203 STKTHPGPVVHLSDSPRDEGKLLI-GYENGTVVFWDLKSKRAELRVY-YDEAIHSIDWHH 260
S + H V+ ++ SP GK L G + TV FWDL ++ + + SI W
Sbjct: 109 SLEGHSEAVISVAFSPT--GKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP 166
Query: 261 EGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGK 294
+G++ +G + LW+ + + +T H K
Sbjct: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSK 200
Score = 33.5 bits (75), Expect = 1.2
Identities = 22/71 (30%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 78 FDPVQKILAIGTRTGAIRIL-GRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLH 136
F P +I+A + +I++ GR G AAV Q+ + + LVS SSD TL
Sbjct: 380 FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439
Query: 137 LWNLRQKRPAI 147
+W+++ ++ A+
Sbjct: 440 VWDVKAQKLAM 450
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 39.3 bits (90), Expect = 0.023
Identities = 53/231 (22%), Positives = 89/231 (38%), Gaps = 43/231 (18%)
Query: 75 ALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDT 134
++A P +A+G R IRI Q ++ + ++ LVS + D +
Sbjct: 1932 SVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGS 1991
Query: 135 LHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGY-- 192
L W L++ C L QS WL ++ + + + S
Sbjct: 1992 LQGWALKE------------------CSL--QSLWLLSRFQKPVLGLATSQELLASASED 2031
Query: 193 --VIMW--------NKAIELSTKT----HPGPVVHLSDSPRDEGKLLIGYENGTVVFWDL 238
V +W +KA + T H GPV S S D G L G + +++ WD+
Sbjct: 2032 FTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFST-DGGSLATGGRDRSLLCWDV 2090
Query: 239 KSKRAELRVYYDEAIH-----SIDWHHEGKQFMCSHSDGSLTLWNLKSPSR 284
++ + + ++ A H W + CS SDGS+ LW+ +S R
Sbjct: 2091 RTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCS-SDGSVGLWDPESGQR 2140
Score = 38.5 bits (88), Expect = 0.038
Identities = 37/159 (23%), Positives = 66/159 (41%), Gaps = 13/159 (8%)
Query: 123 EGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIV 182
E +VS S D TL +W+ + L S+ + I++C + + G +V
Sbjct: 2158 EEHVVSVSRDGTLKVWD---HQGVELTSIPAHSGPISHCAAAMEPR--AAGQPGSELLVV 2212
Query: 183 NIESFILSGYVIMWNKAIELSTKT---HPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLK 239
+ L G +W+ + T T H GPV + S G +L E+G+V W +
Sbjct: 2213 TVG---LDGATRLWHPLLVCQTHTLLGHSGPVRAAAVS-ETSGLMLTASEDGSVRLWQVP 2268
Query: 240 SKRAELRVYYDEA-IHSIDWHHEGKQFMCSHSDGSLTLW 277
+ + + A + ++ W +G + + G L LW
Sbjct: 2269 KEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILW 2307
Score = 31.2 bits (69), Expect = 6.1
Identities = 19/78 (24%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 66 RHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQ-HESGAAVLQLQFLINEG 124
+H +P +AF P +++A G+ G+I G+ GA++ L F + G
Sbjct: 1796 QHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGG 1855
Query: 125 ALVSASSDDTLHLWNLRQ 142
+ D + LW R+
Sbjct: 1856 VVAVGRLDSMVELWAWRE 1873
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 37.7 bits (86), Expect = 0.066
Identities = 44/187 (23%), Positives = 75/187 (40%), Gaps = 28/187 (14%)
Query: 117 LQFLINEGALVSASSDDTLHLWNLRQK-----------RPAILHSLKFNRERITYCHLPF 165
+QF VS S D T +W +++ RPA +L+ ++IT
Sbjct: 371 IQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPA-GQNLQGIEDKIT------ 423
Query: 166 QSKWLYVGTER-GNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKL 224
+ K V +R NT I + + L + + I + H V L P D L
Sbjct: 424 KMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHV-LMGHEDEVFVLEPHPFDPRVL 482
Query: 225 LIGYENGTVVFWDLKSKRAELRVYYD-------EAIHSIDWHHEGKQFMCSHSDGSLTLW 277
+G V+ WDL ++ ++R Y++ A+ +G+ F C+ S G L ++
Sbjct: 483 FSAGHDGNVIVWDL-ARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIF 541
Query: 278 NLKSPSR 284
S S+
Sbjct: 542 GFGSSSK 548
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 37.7 bits (86), Expect = 0.066
Identities = 40/159 (25%), Positives = 69/159 (43%), Gaps = 13/159 (8%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHI-VNI 184
L S S D TL +W+++Q +H L+ + + I + KW G N + + +
Sbjct: 364 LASCSDDMTLKIWSMKQDN--CVHDLQAHNKEI------YTIKWSPTGPGTNNPNANLML 415
Query: 185 ESFILSGYVIMWN--KAIELSTKT-HPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSK 241
S V +W+ + I + T T H PV ++ SP D L G + V W+ ++
Sbjct: 416 ASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP-DGRYLASGSFDKCVHIWNTQTG 474
Query: 242 RAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280
I + W+ G + S SDGS+ + +L+
Sbjct: 475 ALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 37.4 bits (85), Expect = 0.086
Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 10/136 (7%)
Query: 114 VLQLQFLINEGALVSASSDDTLHLWNLR-----QKRPAI----LHSLKFNRERITYCHLP 164
+ L F ++ AL++AS D TL LWNL+ +K A+ +H+ + +R + +
Sbjct: 448 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 507
Query: 165 FQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKL 224
S++ Y G H I + Y + + H V L+ SP + +L
Sbjct: 508 SNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQ-RL 566
Query: 225 LIGYENGTVVFWDLKS 240
+GTV WD S
Sbjct: 567 ASCSADGTVRIWDPSS 582
Score = 35.0 bits (79), Expect = 0.42
Identities = 46/215 (21%), Positives = 82/215 (38%), Gaps = 19/215 (8%)
Query: 100 PGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERIT 159
P V + G AV L F L S S+D T+ +W+ PA L + E
Sbjct: 540 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 599
Query: 160 YCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAI-----ELSTKTHPGPV-VH 213
+ F S T +I + SG ++++ + L ++ GP ++
Sbjct: 600 PTSVAFTS-----------TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQIN 648
Query: 214 LSDSPRDEGKLLIGYENGTVVFWDLKS-KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDG 272
S ++ + +++ + F D ++ K V + +A+ + G M D
Sbjct: 649 QVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDC 708
Query: 273 SLTLWNLKSPSRPFQTTIPHGKSQREGRKSESCKP 307
SL LW+L + + Q H K E + +C P
Sbjct: 709 SLRLWSLDNKT-CVQEITAHRKKHEEAIHAVACHP 742
Score = 33.5 bits (75), Expect = 1.2
Identities = 15/36 (41%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 245 LRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280
LR +YD I S+ +HH + + DG+L LWNL+
Sbjct: 441 LRSHYD-GIRSLAFHHSQSALLTASEDGTLKLWNLQ 475
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 37.4 bits (85), Expect = 0.086
Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 10/136 (7%)
Query: 114 VLQLQFLINEGALVSASSDDTLHLWNLR-----QKRPAI----LHSLKFNRERITYCHLP 164
+ L F ++ AL++AS D TL LWNL+ +K A+ +H+ + +R + +
Sbjct: 441 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 500
Query: 165 FQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKL 224
S++ Y G H I + Y + + H V L+ SP + +L
Sbjct: 501 SNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQ-RL 559
Query: 225 LIGYENGTVVFWDLKS 240
+GTV WD S
Sbjct: 560 ASCSADGTVRIWDPSS 575
Score = 35.0 bits (79), Expect = 0.42
Identities = 46/215 (21%), Positives = 82/215 (38%), Gaps = 19/215 (8%)
Query: 100 PGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERIT 159
P V + G AV L F L S S+D T+ +W+ PA L + E
Sbjct: 533 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 592
Query: 160 YCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAI-----ELSTKTHPGPV-VH 213
+ F S T +I + SG ++++ + L ++ GP ++
Sbjct: 593 PTSVAFTS-----------TEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQIN 641
Query: 214 LSDSPRDEGKLLIGYENGTVVFWDLKS-KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDG 272
S ++ + +++ + F D ++ K V + +A+ + G M D
Sbjct: 642 QVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDC 701
Query: 273 SLTLWNLKSPSRPFQTTIPHGKSQREGRKSESCKP 307
SL LW+L + + Q H K E + +C P
Sbjct: 702 SLRLWSLDNKT-CVQEITAHRKKHEEAIHAVACHP 735
Score = 33.5 bits (75), Expect = 1.2
Identities = 15/36 (41%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 245 LRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280
LR +YD I S+ +HH + + DG+L LWNL+
Sbjct: 434 LRSHYD-GIRSLAFHHSQSALLTASEDGTLKLWNLQ 468
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 37.4 bits (85), Expect = 0.086
Identities = 36/148 (24%), Positives = 61/148 (41%), Gaps = 31/148 (20%)
Query: 126 LVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIE 185
+ SAS D T+ +W++ ++ +L N+ + P + T+R
Sbjct: 271 ICSASWDHTIRVWDVESG--SLKSTLTGNKVFNCISYSPLCKRLASGSTDR--------- 319
Query: 186 SFILSGYVIMWN------KAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLK 239
++ +W+ + LS +H G V + SP E +L+ G + V WD +
Sbjct: 320 ------HIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTR 373
Query: 240 SKRAELRVYYDEAIH-----SIDWHHEG 262
S +A L YD A H S+DW G
Sbjct: 374 SCKAPL---YDLAAHEDKVLSVDWTDTG 398
>gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform 2
[Homo sapiens]
Length = 1006
Score = 37.4 bits (85), Expect = 0.086
Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 15/179 (8%)
Query: 112 AAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERI----TYCHLPFQS 167
A VL L F + L SAS D ++ +W + + AI L + + C L +Q
Sbjct: 14 APVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQP 73
Query: 168 KWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIG 227
K G + +E + W+ +LS + ++ SP + L G
Sbjct: 74 K-------SGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQ-YLAAG 125
Query: 228 YENGTVVFWDLKSKRAELRVYYDE--AIHSIDWHHEGKQFMCSHSDGSL-TLWNLKSPS 283
NG ++ W++++K RV +++ AI + WH + + ++G+L L N+ PS
Sbjct: 126 SINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENVCDPS 184
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,256,605
Number of Sequences: 37866
Number of extensions: 2281591
Number of successful extensions: 11366
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 10491
Number of HSP's gapped (non-prelim): 889
length of query: 1186
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1073
effective length of database: 13,968,660
effective search space: 14988372180
effective search space used: 14988372180
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.