Search of human proteins with 7662310

Search of human proteins with 7662310

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
         (1054 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...  2135   0.0  
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...  1121   0.0  
gi|34916000 FERM domain containing 7 [Homo sapiens]                   388   e-107
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   283   6e-76
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s...   257   4e-68
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...   250   4e-66
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...   250   4e-66
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...   250   4e-66
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi...   243   7e-64
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis...   243   7e-64
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform...   243   9e-64
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform...   243   9e-64
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s...   213   1e-54
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi...   210   5e-54
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo...   201   2e-51
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo...   201   2e-51
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]         191   4e-48
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]   182   2e-45
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...   178   2e-44
gi|117500790 FERM domain containing 3 [Homo sapiens]                  178   3e-44
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...   174   4e-43
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]        174   4e-43
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]   166   1e-40
gi|24797153 faciogenital dysplasia protein [Homo sapiens]             164   5e-40
gi|4506467 radixin [Homo sapiens]                                     139   1e-32
gi|4505257 moesin [Homo sapiens]                                      135   2e-31
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]   133   1e-30
gi|161702986 ezrin [Homo sapiens]                                     128   2e-29
gi|21614499 ezrin [Homo sapiens]                                      128   2e-29
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...   124   5e-28

>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
            sapiens]
          Length = 1054

 Score = 2135 bits (5532), Expect = 0.0
 Identities = 1054/1054 (100%), Positives = 1054/1054 (100%)

Query: 1    MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI 60
            MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI
Sbjct: 1    MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI 60

Query: 61   EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA 120
            EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA
Sbjct: 61   EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA 120

Query: 121  VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD 180
            VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD
Sbjct: 121  VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD 180

Query: 181  REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE 240
            REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE
Sbjct: 181  REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE 240

Query: 241  GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL 300
            GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL
Sbjct: 241  GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL 300

Query: 301  GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM 360
            GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM
Sbjct: 301  GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM 360

Query: 361  KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLP 420
            KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLP
Sbjct: 361  KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLP 420

Query: 421  EFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPS 480
            EFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPS
Sbjct: 421  EFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPS 480

Query: 481  PSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIV 540
            PSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIV
Sbjct: 481  PSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIV 540

Query: 541  KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR 600
            KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR
Sbjct: 541  KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR 600

Query: 601  LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAV 660
            LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAV
Sbjct: 601  LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAV 660

Query: 661  YKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVT 720
            YKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVT
Sbjct: 661  YKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVT 720

Query: 721  TTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSD 780
            TTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSD
Sbjct: 721  TTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSD 780

Query: 781  MLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEK 840
            MLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEK
Sbjct: 781  MLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEK 840

Query: 841  EKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGH 900
            EKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGH
Sbjct: 841  EKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGH 900

Query: 901  GQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFF 960
            GQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFF
Sbjct: 901  GQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFF 960

Query: 961  YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEV 1020
            YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEV
Sbjct: 961  YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEV 1020

Query: 1021 IQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE 1054
            IQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE
Sbjct: 1021 IQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE 1054


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
            [Homo sapiens]
          Length = 1045

 Score = 1121 bits (2900), Expect = 0.0
 Identities = 577/1056 (54%), Positives = 737/1056 (69%), Gaps = 49/1056 (4%)

Query: 1    MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI 60
            MGEIE       T G RLGA    G+STLE GQ   P    K + +++++LD+T E F++
Sbjct: 1    MGEIEQR----PTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEV 56

Query: 61   EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA 120
              +  G+VLL  V   LNLVE DYFG+EF + +   +WL+ +KPI++QIRRPK+VV++  
Sbjct: 57   PQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFV 116

Query: 121  VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD 180
            VKFFPPD  QLQEE TRYLFALQ+K+DL + RLTC DT+AALL SH++QSEIGD+DE LD
Sbjct: 117  VKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALD 176

Query: 181  REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE 240
            REHL  N+Y+P Q    +KI+EFH  H+GQTPAESDFQ+LEIAR+LEMYGIR H A DRE
Sbjct: 177  REHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDRE 236

Query: 241  GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL 300
            GTKI LAV++ G+LVFQG TKIN FNW+KVRKLSFKRKRFLIKL P+ +  YQDTLEFL+
Sbjct: 237  GTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLM 296

Query: 301  GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM 360
             SRD CK+FWKICVE+H FFRL ++PKPK K V FSRGSSFR+SGRTQKQ++DY K+ G 
Sbjct: 297  ASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGH 356

Query: 361  KRIPYERRHSKTHTSVRALTA------------DLPKQSISFPEGLRTPASPSSANAFYS 408
            K++ +ER+HSK H S+R+L +                 S++F EG  +P   S       
Sbjct: 357  KKVQFERKHSKIH-SIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRR---- 411

Query: 409  LSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPS-------AQPL 461
                  V +G P         + P  +  +SPA  +++   A  P            Q  
Sbjct: 412  -GKEPKVSAGEPG--------SHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQS 462

Query: 462  GPPALQPGPGLSTKSPQPSPSSRKSPLSLSPA---FQVPLGPAEQGSSPLLSPVLSDAGG 518
             P   QP  G  T SP  S  S  S   ++PA       L P  + +SPL+SP+L+D   
Sbjct: 463  KPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQAC 522

Query: 519  AGMDCE-EPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMT 577
               D E E R KR P D+AYFI KE+  TERTYLKDLEVIT WF+S V KEDAMP  L +
Sbjct: 523  PRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKS 582

Query: 578  LLFSNIDPIYEFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYF 637
            L+F N +P+++FH  FL+E+EQRLALWEG S A  +  +QRIGD++L+N++ +K   ++ 
Sbjct: 583  LIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIR-DYQRIGDVMLKNIQGMKHLAAHL 641

Query: 638  QRHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCG 697
             +H E L  LE   K  ++LE   ++FELQKVCYLPLNTFLL+P+ RL+HY+ +L RLC 
Sbjct: 642  WKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCK 701

Query: 698  HYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFI 757
            H+ P H D+ DC  AL  ITE+   L   +I++EN QKL EL++DL+GI+NL+ PGREFI
Sbjct: 702  HHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFI 761

Query: 758  REGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSV 817
            R G L KL+ KGLQQRMFFLF+D+LLYTS+G+  ++ F++ G LPL GM +EES++EW V
Sbjct: 762  RLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGV 821

Query: 818  PHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPP--R 875
            PHC T+   +++I+VAAS+R E EKW+ D+  AI  A+     AP      + + PP  +
Sbjct: 822  PHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEF----LASSPPDNK 877

Query: 876  SPNE-VSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSG 934
            SP+E  + +QESEDD    R+SLE    HR NT +HVCW+RNTSVS  D S AVENQLSG
Sbjct: 878  SPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSG 937

Query: 935  YLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYV 994
             LLRKFKNS+GWQKLWVVFTNFCLFFYK+HQD++PLASLPLLGYS++IP E++ I KDYV
Sbjct: 938  NLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYV 997

Query: 995  FKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGR 1030
            FKL FKSHVY+FRAES+YTFERWMEVI+ A+SSA R
Sbjct: 998  FKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASR 1033


>gi|34916000 FERM domain containing 7 [Homo sapiens]
          Length = 714

 Score =  388 bits (997), Expect = e-107
 Identities = 187/327 (57%), Positives = 241/327 (73%), Gaps = 2/327 (0%)

Query: 44  LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103
           LHL+V+ LD++ +IF ++ K  G+ L       LNL E +YFG+EF +     +WLE +K
Sbjct: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61

Query: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163
           PI +Q++ PK +V +  VKFFP DPG L+EE TRYLF LQ+K+DL   RL C+D   AL+
Sbjct: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121

Query: 164 TSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEI 222
            SH+LQSE+GD+ E  DR+HL    YLP Q  CLE KI+ FHQKH+G++PAESD  +L+I
Sbjct: 122 VSHILQSELGDFHEETDRKHLAQTRYLPNQD-CLEGKIMHFHQKHIGRSPAESDILLLDI 180

Query: 223 ARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLI 282
           ARKL+MYGIR H ASD EG +I LAV+HMGVLV +G TKINTFNW+K+RKLSFKRK FLI
Sbjct: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240

Query: 283 KLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFR 342
           KLH  +    +DTLEF + SRD CK FWK CVEYH FFRL ++PK K K +  S+GSSFR
Sbjct: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300

Query: 343 YSGRTQKQLVDYFKDSGMKRIPYERRH 369
           YSGRTQ+QL++Y +   +K +P+ER+H
Sbjct: 301 YSGRTQRQLLEYGRKGRLKSLPFERKH 327


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  283 bits (724), Expect = 6e-76
 Identities = 180/489 (36%), Positives = 262/489 (53%), Gaps = 40/489 (8%)

Query: 40  QEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEF-QNTQSYWIW 98
           Q   +   + LLDNT++ F +     GQVLL  V+K L+L E DYFG++   ++     W
Sbjct: 25  QHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRW 84

Query: 99  LEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADT 158
           L+P KPI +Q++R     L   VKFF  DP +LQEEYTRY + LQ+K+D+L  RL C   
Sbjct: 85  LDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSN 144

Query: 159 TAALLTSHLLQSEIGDYDETLDRE-HLKVNEYLPGQQHCLEK-ILEFHQKHVGQTPAESD 216
           TAALL S  +QSE+GDYD++ +   +L    ++P Q    EK I + HQ+H+G +PAE++
Sbjct: 145 TAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAE 204

Query: 217 FQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK 276
           F  L  AR LE+YG+ FH A D+   +I + V   G+L+++   ++NTF W K+ K+SFK
Sbjct: 205 FNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFK 264

Query: 277 RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAK---AV 333
            K+F I+L  E+H   +  L F + +   CKN WK CVE+HTFFR LD+P P  K   A 
Sbjct: 265 CKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFR-LDRPLPPQKNFFAH 323

Query: 334 FFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSK------------THTSV---RA 378
           +F+ GS FRY GRT+ Q V Y K+   K   + R  SK            +  S+   R 
Sbjct: 324 YFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRL 383

Query: 379 LTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYV- 437
            T  LP +S         P +P+  N+ ++   + L PS +    D     T P   +V 
Sbjct: 384 ETQSLPSRS--------PPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVH-TSPSEVFVN 434

Query: 438 -KSPAAERRSGAVAGGPDTPSAQPLG---PPALQPGPGLSTKSPQPSPSSRKSPLS--LS 491
            +SP++ + +  V     +PS +  G   PPAL P         Q   S  +  L   ++
Sbjct: 435 QRSPSSTQANSIVL--ESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHIN 492

Query: 492 PAFQVPLGP 500
             F +P  P
Sbjct: 493 ETFDIPSSP 501


>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
           sapiens]
          Length = 1087

 Score =  257 bits (657), Expect = 4e-68
 Identities = 161/443 (36%), Positives = 234/443 (52%), Gaps = 32/443 (7%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           K +  +V LLD +    D+E +  GQVL  +V + LNL+E DYFG+ +++ ++   WL+P
Sbjct: 108 KSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDP 167

Query: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161
            K I +Q+R          VKF+PPDP QL E+ TRY   LQL+ D++  RL C+  T A
Sbjct: 168 AKEIKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLA 226

Query: 162 LLTSHLLQSEIGDYD-ETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQV 219
           LL S+ +QSE+GDYD +    +++    + P     LE K++E H+ H G TPAE++   
Sbjct: 227 LLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHF 286

Query: 220 LEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKR 279
           LE A+KL MYG+  H A D EG +I L V   G+L+++   +IN F W KV K+S+KR  
Sbjct: 287 LENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNN 346

Query: 280 FLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGS 339
           F IK+ P     ++ T+ F L +    K  WK+CVE+HTFFRLL    P  K  F + GS
Sbjct: 347 FYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKK--FLTLGS 404

Query: 340 SFRYSGRTQKQ------LVDYFKDSGMKRIPY-ERRHSKTHTSVRALTADLPKQSISFPE 392
            FRYSGRTQ Q      L+D       +  PY ER  SK +T  R+L  ++     +  +
Sbjct: 405 KFRYSGRTQAQTRRASALID-------RPAPYFERSSSKRYTMSRSLDGEVGTGQYATTK 457

Query: 393 GLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVAGG 452
           G+      S  N   +++P         E +D      +       +P +  R    + G
Sbjct: 458 GI------SQTNLITTVTPEKKAEEERDEEEDKRRKGEE------VTPISAIRHEGKSPG 505

Query: 453 PDTPSAQPLGPPALQPGPGLSTK 475
             T S  PL PP+    P   T+
Sbjct: 506 LGTDSC-PLSPPSTHCAPTSPTE 527


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  250 bits (639), Expect = 4e-66
 Identities = 145/358 (40%), Positives = 205/358 (57%), Gaps = 20/358 (5%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           K +  +V LLD T    D+E    GQVL  +V + LNL+E DYFG+ FQ +     WL+P
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275

Query: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161
            K I RQ+R     +    VKF+PPDP QL E+ TRY   LQL++D+   RL C+  T A
Sbjct: 276 AKEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334

Query: 162 LLTSHLLQSEIGDYDETLDREHLKVN----EYLPGQQHCLE-KILEFHQKHVGQTPAESD 216
           LL S+ LQ+E+GDYD     EH  ++    ++ P Q   LE K+ E H+ H G +PA++D
Sbjct: 335 LLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQAD 391

Query: 217 FQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK 276
            Q LE A++L MYG+  H A D EG  I+L V   G+L+++   +IN F W K+ K+S+K
Sbjct: 392 SQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYK 451

Query: 277 RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFS 336
           R  F IK+ P     ++ T+ F L +    K  WK+CVE+HTF+RL+  P+   KA F +
Sbjct: 452 RSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKAKFLT 510

Query: 337 RGSSFRYSGRTQKQ------LVD----YFKDSGMKRIPYERRHSKTHTSVRALTADLP 384
            GS FRYSGRTQ Q      L+D    +F+ +  KR+      +      ++L  D P
Sbjct: 511 LGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFP 568


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  250 bits (639), Expect = 4e-66
 Identities = 145/358 (40%), Positives = 205/358 (57%), Gaps = 20/358 (5%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           K +  +V LLD T    D+E    GQVL  +V + LNL+E DYFG+ FQ +     WL+P
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275

Query: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161
            K I RQ+R     +    VKF+PPDP QL E+ TRY   LQL++D+   RL C+  T A
Sbjct: 276 AKEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334

Query: 162 LLTSHLLQSEIGDYDETLDREHLKVN----EYLPGQQHCLE-KILEFHQKHVGQTPAESD 216
           LL S+ LQ+E+GDYD     EH  ++    ++ P Q   LE K+ E H+ H G +PA++D
Sbjct: 335 LLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQAD 391

Query: 217 FQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK 276
            Q LE A++L MYG+  H A D EG  I+L V   G+L+++   +IN F W K+ K+S+K
Sbjct: 392 SQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYK 451

Query: 277 RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFS 336
           R  F IK+ P     ++ T+ F L +    K  WK+CVE+HTF+RL+  P+   KA F +
Sbjct: 452 RSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKAKFLT 510

Query: 337 RGSSFRYSGRTQKQ------LVD----YFKDSGMKRIPYERRHSKTHTSVRALTADLP 384
            GS FRYSGRTQ Q      L+D    +F+ +  KR+      +      ++L  D P
Sbjct: 511 LGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFP 568


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score =  250 bits (639), Expect = 4e-66
 Identities = 145/358 (40%), Positives = 205/358 (57%), Gaps = 20/358 (5%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           K +  +V LLD T    D+E    GQVL  +V + LNL+E DYFG+ FQ +     WL+P
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275

Query: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161
            K I RQ+R     +    VKF+PPDP QL E+ TRY   LQL++D+   RL C+  T A
Sbjct: 276 AKEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334

Query: 162 LLTSHLLQSEIGDYDETLDREHLKVN----EYLPGQQHCLE-KILEFHQKHVGQTPAESD 216
           LL S+ LQ+E+GDYD     EH  ++    ++ P Q   LE K+ E H+ H G +PA++D
Sbjct: 335 LLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQAD 391

Query: 217 FQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK 276
            Q LE A++L MYG+  H A D EG  I+L V   G+L+++   +IN F W K+ K+S+K
Sbjct: 392 SQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYK 451

Query: 277 RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFS 336
           R  F IK+ P     ++ T+ F L +    K  WK+CVE+HTF+RL+  P+   KA F +
Sbjct: 452 RSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKAKFLT 510

Query: 337 RGSSFRYSGRTQKQ------LVD----YFKDSGMKRIPYERRHSKTHTSVRALTADLP 384
            GS FRYSGRTQ Q      L+D    +F+ +  KR+      +      ++L  D P
Sbjct: 511 LGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFP 568


>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 2 [Homo sapiens]
          Length = 641

 Score =  243 bits (620), Expect = 7e-64
 Identities = 137/311 (44%), Positives = 187/311 (60%), Gaps = 8/311 (2%)

Query: 44  LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103
           +H +V LLD+T+    +E    GQ LL +V + LNL+E DYFG+   +  +   WL+  K
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 104 PIIRQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAAL 162
            I +Q+R  P N      VKF+PPDP QL E+ TRY   LQL++D++  RL C+  T AL
Sbjct: 61  EIKKQVRGVPWNFTFN--VKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLAL 118

Query: 163 LTSHLLQSEIGDYDETLDR-EHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220
           L S+ +QSE+GDYD  L   +++   +  P Q   LE K++E H+ +   TPA++D + L
Sbjct: 119 LGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFL 178

Query: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280
           E A+KL MYG+  H A D EG  I L V   G+LV++   +IN F W KV K+S+KR  F
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSF 238

Query: 281 LIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPK-PKAKAVFFSRGS 339
            IK+ P     Y+ T+ F L S    K  WK+CVE+HTFFRL      PK+K  F + GS
Sbjct: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK--FLALGS 296

Query: 340 SFRYSGRTQKQ 350
            FRYSGRTQ Q
Sbjct: 297 KFRYSGRTQAQ 307


>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
           RH-linked) isoform 3 [Homo sapiens]
          Length = 588

 Score =  243 bits (620), Expect = 7e-64
 Identities = 137/311 (44%), Positives = 187/311 (60%), Gaps = 8/311 (2%)

Query: 44  LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103
           +H +V LLD+T+    +E    GQ LL +V + LNL+E DYFG+   +  +   WL+  K
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 104 PIIRQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAAL 162
            I +Q+R  P N      VKF+PPDP QL E+ TRY   LQL++D++  RL C+  T AL
Sbjct: 61  EIKKQVRGVPWNFTFN--VKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLAL 118

Query: 163 LTSHLLQSEIGDYDETLDR-EHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220
           L S+ +QSE+GDYD  L   +++   +  P Q   LE K++E H+ +   TPA++D + L
Sbjct: 119 LGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFL 178

Query: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280
           E A+KL MYG+  H A D EG  I L V   G+LV++   +IN F W KV K+S+KR  F
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSF 238

Query: 281 LIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPK-PKAKAVFFSRGS 339
            IK+ P     Y+ T+ F L S    K  WK+CVE+HTFFRL      PK+K  F + GS
Sbjct: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK--FLALGS 296

Query: 340 SFRYSGRTQKQ 350
            FRYSGRTQ Q
Sbjct: 297 KFRYSGRTQAQ 307


>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
           [Homo sapiens]
          Length = 779

 Score =  243 bits (619), Expect = 9e-64
 Identities = 141/337 (41%), Positives = 193/337 (57%), Gaps = 9/337 (2%)

Query: 47  RVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPII 106
           RV LLD +    ++E    GQVL   V + LNL+E DYFG+ F +  S   WL+P K I 
Sbjct: 38  RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97

Query: 107 RQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTS 165
           +QIR  P N      VKF+PPDP QL E+ TRY   LQL+ D++  RL C+  T ALL S
Sbjct: 98  KQIRSSPWNFAF--TVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155

Query: 166 HLLQSEIGDYD-ETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEIA 223
           + +Q+E+GDYD E     ++    + P Q   LE +I+E H+ + G TP E++   LE A
Sbjct: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 215

Query: 224 RKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIK 283
           +KL MYG+  H A D EG  I L V   G+L+++   +IN F W K+ K+S+KR  F IK
Sbjct: 216 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 275

Query: 284 LHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLD-QPKPKAKAVFFSRGSSFR 342
           + P  +  ++ T+ F L +    K  WK+C+E+HTFFRL+  +P PK    F   GS FR
Sbjct: 276 IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG---FLVMGSKFR 332

Query: 343 YSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRAL 379
           YSGRTQ Q              +ER  SK +T  R+L
Sbjct: 333 YSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 369


>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
           [Homo sapiens]
          Length = 881

 Score =  243 bits (619), Expect = 9e-64
 Identities = 141/337 (41%), Positives = 193/337 (57%), Gaps = 9/337 (2%)

Query: 47  RVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPII 106
           RV LLD +    ++E    GQVL   V + LNL+E DYFG+ F +  S   WL+P K I 
Sbjct: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159

Query: 107 RQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTS 165
           +QIR  P N      VKF+PPDP QL E+ TRY   LQL+ D++  RL C+  T ALL S
Sbjct: 160 KQIRSSPWNFAF--TVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217

Query: 166 HLLQSEIGDYD-ETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEIA 223
           + +Q+E+GDYD E     ++    + P Q   LE +I+E H+ + G TP E++   LE A
Sbjct: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 277

Query: 224 RKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIK 283
           +KL MYG+  H A D EG  I L V   G+L+++   +IN F W K+ K+S+KR  F IK
Sbjct: 278 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 337

Query: 284 LHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLD-QPKPKAKAVFFSRGSSFR 342
           + P  +  ++ T+ F L +    K  WK+C+E+HTFFRL+  +P PK    F   GS FR
Sbjct: 338 IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG---FLVMGSKFR 394

Query: 343 YSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRAL 379
           YSGRTQ Q              +ER  SK +T  R+L
Sbjct: 395 YSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 431


>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
           sapiens]
          Length = 733

 Score =  213 bits (541), Expect = 1e-54
 Identities = 129/334 (38%), Positives = 186/334 (55%), Gaps = 9/334 (2%)

Query: 47  RVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPII 106
           RV LLD T    D+  K  GQ L  Q+   L+L+E DYFG+ F ++     WL+  K I 
Sbjct: 46  RVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIK 105

Query: 107 RQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSH 166
           +Q++      L L VKF+  +P  L+EE TRYLF LQLK+D+L  +L C   TA  L ++
Sbjct: 106 KQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAY 165

Query: 167 LLQSEIGDYDETLDREHLKVNE--YLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEIA 223
            LQ+E+GDYD       L V+E  ++P Q   +E  I E  +++ GQTPA+++   L  A
Sbjct: 166 NLQAELGDYDLAEHSPEL-VSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKA 224

Query: 224 RKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF-LI 282
           + LEMYG+  H+   R+G    L ++  GVLVF+G TKI  F W K+ +L FK+ +  L+
Sbjct: 225 KWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLV 284

Query: 283 KLHPEVHGPYQD-TLEFLLGSRDECKNFWKICVEYHTFFRLLDQ-PKPKAKAVFFSRGSS 340
            +  +  G  Q+ T  F L     CK+ WK  VE+H FFRL     K   ++ F   GS 
Sbjct: 285 VVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSR 344

Query: 341 FRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHT 374
           FRYSG+T+ Q      +   +   +ERR SK ++
Sbjct: 345 FRYSGKTEYQTTK--TNKARRSTSFERRPSKRYS 376


>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 1 [Homo sapiens]
          Length = 775

 Score =  210 bits (535), Expect = 5e-54
 Identities = 117/257 (45%), Positives = 156/257 (60%), Gaps = 8/257 (3%)

Query: 98  WLEPMKPIIRQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCA 156
           WL+  K I +Q+R  P N      VKF+PPDP QL E+ TRY   LQL++D++  RL C+
Sbjct: 229 WLDSAKEIKKQVRGVPWNFTFN--VKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCS 286

Query: 157 DTTAALLTSHLLQSEIGDYDETLDR-EHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAE 214
             T ALL S+ +QSE+GDYD  L   +++   +  P Q   LE K++E H+ +   TPA+
Sbjct: 287 FATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQ 346

Query: 215 SDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLS 274
           +D + LE A+KL MYG+  H A D EG  I L V   G+LV++   +IN F W KV K+S
Sbjct: 347 ADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKIS 406

Query: 275 FKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPK-PKAKAV 333
           +KR  F IK+ P     Y+ T+ F L S    K  WK+CVE+HTFFRL      PK+K  
Sbjct: 407 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK-- 464

Query: 334 FFSRGSSFRYSGRTQKQ 350
           F + GS FRYSGRTQ Q
Sbjct: 465 FLALGSKFRYSGRTQAQ 481


>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
           1 [Homo sapiens]
          Length = 518

 Score =  201 bits (512), Expect = 2e-51
 Identities = 122/344 (35%), Positives = 191/344 (55%), Gaps = 10/344 (2%)

Query: 44  LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103
           L+ RV LLD T    D+     GQ L  Q+   L+LVE DYFG++F ++     WL+  K
Sbjct: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144

Query: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163
           PI +Q++      L   VK++  +P  L+EE+TRYLF LQL+ D+L  +L C   TA  L
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204

Query: 164 TSHLLQSEIGDYDETLDREHLKVNE--YLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220
            +  LQ+E+G+ +       L V+E  ++P Q   +E  I +  ++  G++PA+++   L
Sbjct: 205 AALCLQAELGECELPEHTPEL-VSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263

Query: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280
             A+ LEMYG+  H+   R+G +  L ++  G+L+F+G  KI  F W K+ K+ FK+ + 
Sbjct: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323

Query: 281 -LIKLHPEVHGPYQD-TLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKA-KAVFFSR 337
            L+ +  +  G  Q+ T  F L S   CK+ WK  VE+H FFRL      K+ ++ F   
Sbjct: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383

Query: 338 GSSFRYSGRTQKQLVD---YFKDSGMKRIPYERRHSKTHTSVRA 378
           GS FR+SGRT+ Q        + S  +R P +R  S+ H++ +A
Sbjct: 384 GSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKA 427


>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
           2 [Homo sapiens]
          Length = 900

 Score =  201 bits (512), Expect = 2e-51
 Identities = 122/344 (35%), Positives = 191/344 (55%), Gaps = 10/344 (2%)

Query: 44  LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103
           L+ RV LLD T    D+     GQ L  Q+   L+LVE DYFG++F ++     WL+  K
Sbjct: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144

Query: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163
           PI +Q++      L   VK++  +P  L+EE+TRYLF LQL+ D+L  +L C   TA  L
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204

Query: 164 TSHLLQSEIGDYDETLDREHLKVNE--YLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220
            +  LQ+E+G+ +       L V+E  ++P Q   +E  I +  ++  G++PA+++   L
Sbjct: 205 AALCLQAELGECELPEHTPEL-VSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263

Query: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280
             A+ LEMYG+  H+   R+G +  L ++  G+L+F+G  KI  F W K+ K+ FK+ + 
Sbjct: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323

Query: 281 -LIKLHPEVHGPYQD-TLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKA-KAVFFSR 337
            L+ +  +  G  Q+ T  F L S   CK+ WK  VE+H FFRL      K+ ++ F   
Sbjct: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383

Query: 338 GSSFRYSGRTQKQLVD---YFKDSGMKRIPYERRHSKTHTSVRA 378
           GS FR+SGRT+ Q        + S  +R P +R  S+ H++ +A
Sbjct: 384 GSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKA 427


>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
          Length = 570

 Score =  191 bits (484), Expect = 4e-48
 Identities = 131/396 (33%), Positives = 196/396 (49%), Gaps = 22/396 (5%)

Query: 38  RMQEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWI 97
           R  E+     V+LLD++     I+    GQ L   +   LNL+E DYFG+ F +      
Sbjct: 11  RSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRH 70

Query: 98  WLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCAD 157
           WLE  K +++Q+R      +   VKF+P DP  L+EE TRYL  LQ+KRDL   RL C  
Sbjct: 71  WLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKT 130

Query: 158 TTAALLTSHLLQSEIGDYDETLDRE-HLKVNEYLPGQQHCLE-KILEFHQKHV-GQTPAE 214
           + AALL +++LQ+EIGDYD     E +    ++ P     LE KI E H+  + GQTPA 
Sbjct: 131 SDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPAT 190

Query: 215 SDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLS 274
           S+   L  A+ LE YG+  H   D  G    LA +  G +V QG  +++   W++V KL 
Sbjct: 191 SELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLK 250

Query: 275 FKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRL--LDQPKPKAKA 332
           F+ K F   L+       +  L +   + + CK+ WK  +E   F++L    Q +  + +
Sbjct: 251 FEGKTFY--LYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSS 308

Query: 333 VFFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPE 392
             F +GS FRYSGR  K++++    + +KR P E      H +    +   P    S   
Sbjct: 309 NLFFKGSRFRYSGRVAKEVME--SSAKIKREPPE-----IHRAGMVPSRSCP----SITH 357

Query: 393 GLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSS 428
           G R  + P +      +S    +  GL   +DS+ S
Sbjct: 358 GPRLSSVPRTRRRAVHIS----IMEGLESLRDSAHS 389


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score =  182 bits (461), Expect = 2e-45
 Identities = 167/611 (27%), Positives = 266/611 (43%), Gaps = 93/611 (15%)

Query: 502  EQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWF 561
            E G SPL    L          E+  HK         I  E+L TER Y+  L+++   F
Sbjct: 182  ENGESPLELEQLDQHHEMKETNEQKLHK---------IANELLLTERAYVNRLDLLDQVF 232

Query: 562  RSAVVKE---DAMPATLMTLLFSNIDPIYEFHRGFLR-EVEQRLALWEGPSKAHTKGSHQ 617
               +++E    + PA ++  +FSNI  I  FH  FL  E+E+R+  WE         +  
Sbjct: 233  YCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWE---------TTP 283

Query: 618  RIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVC-YLPLNT 676
            RIGDIL +    LK +  Y +  D  +  ++  T+R  + ++V +E + QK+C  L L  
Sbjct: 284  RIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQH 343

Query: 677  FLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKL 736
             +L+P+QR+  Y +LL+       P   D+ D   +L+ I+   +     + ++ENL+KL
Sbjct: 344  HMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKL 403

Query: 737  TELQRDLVGIENLIAPGREFIREGCLHKLTKK--GLQQRMFFLFSDMLLY-TSKGVAGTS 793
             E+   L   E+++ P  E I+EG + KL  +    Q+R  FLF++MLLY   K     S
Sbjct: 404  LEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGS 463

Query: 794  HFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQA 853
             F +R  + + GM + E+ NE   PH F +   ++T+ + AS+  +KE+W+  L   I A
Sbjct: 464  KFTVRTRVGIDGMKIVETQNE-EYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDA 522

Query: 854  AKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVR--------------SSLEG 899
                 +T      R    +     +EVS  +  +   R +R              ++L  
Sbjct: 523  FHQRHETF-----RNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTR 577

Query: 900  HGQHRANTTMHVCW----------YRNTSVSR---------ADHSAAVENQLSGYL---- 936
               H       VCW          Y    +S+         +  + + E +  G L    
Sbjct: 578  RRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIES 637

Query: 937  ------------LRKFKNSHGWQKLWVVFTN---FCLFFYKTHQDDYPLASLPLLGYSV- 980
                        L+  + S  WQK W V        L+ Y   QD    A++PLLGY V 
Sbjct: 638  AEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVD 697

Query: 981  SIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGA-----SSSAGRAPSIV 1035
             +PR AD  H    FKL     V+ F A+S+   ++W++VI  A            P+ +
Sbjct: 698  EMPRSADLPHS---FKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEHPATL 754

Query: 1036 QDGPQPSSGLE 1046
             D P+P    E
Sbjct: 755  DDHPEPKKKSE 765


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score =  178 bits (452), Expect = 2e-44
 Identities = 137/467 (29%), Positives = 218/467 (46%), Gaps = 51/467 (10%)

Query: 48  VKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQ-SYWIWLEPMKPII 106
           +  LD  ++ F +  +  GQVLL  V   L + E +YFG++  +       WLE  K I 
Sbjct: 33  IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIR 92

Query: 107 RQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSH 166
           +Q++      L   V+FF PDP  LQ+E TR+L+ LQLK D+ E RLTC   +A +L S+
Sbjct: 93  KQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASY 152

Query: 167 LLQSEIGDYDETLDRE-HLKVNEYLPGQ-QHCLEKILEFHQKHVGQTPAESDFQVLEIAR 224
            +QS  GDY+ ++    +L  + ++P Q +  L K+   H++H G   +E++   + IAR
Sbjct: 153 AVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIAR 212

Query: 225 KLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKL 284
            L+ YG+  H   D     + + ++  GV V++     + + W  + K+SFKRK+F I  
Sbjct: 213 TLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQ 272

Query: 285 HPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFF---RLLDQPKPKAKAVFFSRGSSF 341
             +     +  + F + +   CKN WK CVE+HTFF   +LL Q K    + +++ GS  
Sbjct: 273 RQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEK-NVLSQYWTMGS-- 329

Query: 342 RYSGRTQKQLVD--YFKD--SGMKRIPYERRH-SKTHTSVRALTADLPK-----QSISFP 391
               R  K+ V+  Y K    GM   P  RR  S  H   ++L +  P      +S    
Sbjct: 330 ----RNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLR 385

Query: 392 EGLRTPASPSSANAFYSLSPSTLVPSGLPEFKDS-SSSLTDPQVSYVKSPAAERRSGAVA 450
             +R P   S+ N    ++  T        +K S +   +D +VS  +SP  E       
Sbjct: 386 HEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQE------- 438

Query: 451 GGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVP 497
                                LS  +P  S  ++KS  S+SP+   P
Sbjct: 439 --------------------SLSENNPAQSYLTQKSSSSVSPSSNAP 465


>gi|117500790 FERM domain containing 3 [Homo sapiens]
          Length = 597

 Score =  178 bits (451), Expect = 3e-44
 Identities = 129/393 (32%), Positives = 202/393 (51%), Gaps = 15/393 (3%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           + +   ++LLD++     I+ +  GQ L+  +    +L+E DYFG+ + + +    WLEP
Sbjct: 30  QEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEP 89

Query: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161
            K I +Q++      +   VKF+P +P +++EE TRYL  LQ+KRD+   RL C+ + AA
Sbjct: 90  NKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAA 149

Query: 162 LLTSHLLQSEIGDYD-ETLDREHLKVNEYLPGQQHCLE-KILEFHQKHV-GQTPAESDFQ 218
            L + ++Q+E+GDYD +     ++   E  P Q   LE KI+E H+  + GQ+P  ++F 
Sbjct: 150 YLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFN 209

Query: 219 VLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRK 278
           +L  A  LE YG+  H   D  GT   L  +  G +VFQG  +I+   W  V KL F+ K
Sbjct: 210 LLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGK 269

Query: 279 RFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLL--DQPKPKAKAVFFS 336
            F +          +  L F   +   CK+ WK  VE   F++     Q K  + +  F 
Sbjct: 270 TFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFF 326

Query: 337 RGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRT 396
           +GS FRYSG+  K++V+    S ++R P E  H    T  R+ +  L KQ I   E L+ 
Sbjct: 327 KGSRFRYSGKVAKEVVE--ASSKIQREPPE-VHRANITQSRS-SHSLNKQLIINMEPLQ- 381

Query: 397 PASPSSANAFYSLSPSTLVPSGLPEFKDSSSSL 429
           P  PS +     L     VP  LP+ ++ S+ L
Sbjct: 382 PLLPSPSEQEEELPLGEGVP--LPKEENISAPL 412


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score =  174 bits (441), Expect = 4e-43
 Identities = 97/286 (33%), Positives = 154/286 (53%), Gaps = 6/286 (2%)

Query: 48  VKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQ-SYWIWLEPMKPII 106
           +  LD  ++ F +  +  GQVLL  V   L + E +YFG++  +       WLE  K I 
Sbjct: 33  IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIR 92

Query: 107 RQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSH 166
           +Q++      L   V+FF PDP  LQ+E TR+L+ LQLK D+ E RLTC   +A +L S+
Sbjct: 93  KQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASY 152

Query: 167 LLQSEIGDYDETLDRE-HLKVNEYLPGQ-QHCLEKILEFHQKHVGQTPAESDFQVLEIAR 224
            +QS  GDY+ ++    +L  + ++P Q +  L K+   H++H G   +E++   + IAR
Sbjct: 153 AVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIAR 212

Query: 225 KLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKL 284
            L+ YG+  H   D     + + ++  GV V++     + + W  + K+SFKRK+F I  
Sbjct: 213 TLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQ 272

Query: 285 HPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFF---RLLDQPK 327
             +     +  + F + +   CKN WK CVE+HTFF   +LL Q K
Sbjct: 273 RQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEK 318


>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
          Length = 686

 Score =  174 bits (441), Expect = 4e-43
 Identities = 134/459 (29%), Positives = 210/459 (45%), Gaps = 33/459 (7%)

Query: 42  KHLHLRVKLLDN-----TMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYW 96
           +  +  V LLD      T +   I+    G V+L  V+  +NLVE DYFG+ + +     
Sbjct: 9   EEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQT 68

Query: 97  IWLEPMKPIIRQ---IRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERL 153
            WL+P K +      I       L   +KF+  DP +L+EE TRY F LQ+K+D+L+ RL
Sbjct: 69  YWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRL 128

Query: 154 TCADTTAALLTSHLLQSEIGDYDETLDRE-HLKVNEYLPGQQHCLEKILE-FHQKHVGQT 211
            C   TAA L ++ +QSE+GDYD       ++    ++P Q+  LE+ +E  H+  +GQ 
Sbjct: 129 PCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQI 188

Query: 212 PAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVR 271
           P+E++   L  A+ LEMYG+  H       ++  L ++ +GV+V++   ++  + W ++ 
Sbjct: 189 PSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRIT 248

Query: 272 KLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDE--CKNFWKICVEYHTFFRLLDQPKPK 329
           K+ FK  +F ++    V G   +   F   +R +  CK+ WK  VE+HTFFR+ +     
Sbjct: 249 KVHFKETQFELR----VLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNS 304

Query: 330 AKAVFFSRGS---SFRYSGRTQKQLV-DYFKDSGMKRIPYERRHSKTHTSVRALTADLPK 385
                   GS     RYSGRT  Q+  D             R  SKT+    A T     
Sbjct: 305 LSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQPAES 364

Query: 386 QSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERR 445
            SIS         + +  N     +   + PS +  FK + +    P     KS A    
Sbjct: 365 NSIS-------RITANMENGENEGTIKIIAPSPVKSFKKAKNE-NSPDTQRSKSHAPWEE 416

Query: 446 SGAVAGGPDTPSAQPLGPP-----ALQPGPGLSTKSPQP 479
           +G  +G  ++PS +   P         P  G    S QP
Sbjct: 417 NGPQSGLYNSPSDRTKSPKFPYTRRRNPSCGSDNDSVQP 455


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score =  166 bits (420), Expect = 1e-40
 Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 29/370 (7%)

Query: 535  EAYFIVKEILATERTYLKDLEVITVWFRSAVVK------EDAMPATLMTLLFSNIDPIYE 588
            + + I KEI+++E+ ++  L+++ + FR AV        +  +   ++  +   +  +YE
Sbjct: 871  KVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYE 930

Query: 589  FHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELE 648
             +R  L+E+E+R+  W            QRI DI ++    LK +++Y +  D+ +  L+
Sbjct: 931  LNRDLLKELEERMLHWT---------EQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLD 981

Query: 649  KATKRCKKLEAVYKEFELQKVCY-LPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYA 707
            +  K+     AV +EFE+   C  L L  +LLKP+QR+  YRLLL     +      DY 
Sbjct: 982  EQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYR 1041

Query: 708  DCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTK 767
            D  DAL  + EV       + + +N QKL ++Q  L G   ++ PGR F++EG L KL++
Sbjct: 1042 DTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSR 1101

Query: 768  KGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQ 827
            K +Q RMFFLF+D LLYT+   +G   +++  +L L GM V +   E +  +   I + +
Sbjct: 1102 KVMQPRMFFLFNDALLYTTPVQSGM--YKLNNMLSLAGMKVRKPTQE-AYQNELKIESVE 1158

Query: 828  KTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESE 887
            ++ +++AS+  E+++W+  ++ AI+          A    T C  P RS +E   E + E
Sbjct: 1159 RSFILSASSATERDEWLEAISRAIEEY--------AKKRITFC--PSRSLDEADSENKEE 1208

Query: 888  DDARGVRSSL 897
                G ++ +
Sbjct: 1209 VSPLGSKAPI 1218



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 32/95 (33%), Positives = 52/95 (54%), Gaps = 3/95 (3%)

Query: 929  ENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADG 988
            ++ +SGYL R   N   W+  W V  N  L+ Y   +D   L S PLLG++V   ++ + 
Sbjct: 1333 DSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTVIQVKDENS 1392

Query: 989  IHKDYVFKLQFKSHV-YFFRAESKYTFERWMEVIQ 1022
              K  VF+L  K+ + Y F+AE  ++ ++W+E  Q
Sbjct: 1393 ESK--VFQLLHKNMLFYVFKAEDAHSAQKWIEAFQ 1425


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score =  164 bits (414), Expect = 5e-40
 Identities = 172/731 (23%), Positives = 296/731 (40%), Gaps = 111/731 (15%)

Query: 384  PKQSISFPEGLRTPASPS-----SANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVK 438
            P + +  P+    P  P      ++   + L+P       +P       S++ P  S   
Sbjct: 238  PPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNS--- 294

Query: 439  SPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPL 498
                E        GP + S  P GPPAL   P       +P      S L      +   
Sbjct: 295  ----EETCFVSDDGPPSHSLCP-GPPALASVPVALADPHRPGSQEVDSDLEEEDDEE--- 346

Query: 499  GPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVIT 558
               E+    +  P++       +  ++         + + I  E+L TE+ Y+  L ++ 
Sbjct: 347  -EEEEKDREIPVPLMERQESVELTVQQ---------KVFHIANELLQTEKAYVSRLHLLD 396

Query: 559  VWFRSAVVKE----DAMPATLMTLLFSNIDPIYEFHRGFLR-EVEQRLALWEGPSKAHTK 613
              F + +++E     + PA ++  +FSNI  IY FH+ FL  E+E+R+  W+        
Sbjct: 397  QVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWD-------- 448

Query: 614  GSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVC-YL 672
              + RIGDIL +    LK +  Y +  D  +  +   T+R  + + +  E + ++ C  L
Sbjct: 449  -RYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNL 507

Query: 673  PLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQH---ILIR 729
             L   +L+P+QR+  Y LLL+    +     H   D  DA K++  + T  +H    + +
Sbjct: 508  TLQHHMLEPVQRIPRYELLLK---DYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRK 564

Query: 730  LENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKG--LQQRMFFLFSDMLLYTSK 787
            +E + KL ++   L G E++++P +E I+EG + KL+ K    Q R   LF+D LLY   
Sbjct: 565  MERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVP 624

Query: 788  GVAGTSH-FRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLD 846
             +      F +R  + + GM ++ES N  ++P  F +   Q+++ + A T  EK+ W+  
Sbjct: 625  RLRLLGQKFSVRARIDVDGMELKESSN-LNLPRTFLVSGKQRSLELQARTEEEKKDWVQA 683

Query: 847  LNSAIQAAKSGGDTAPAL--PGRTVCTRPPRSPN--------------EVSLEQESEDDA 890
            +NS +   +   +T   L    R     PP SPN              EV++    ++  
Sbjct: 684  INSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPF 743

Query: 891  RGVRSSLE-----GH---------------GQHRANTTMHVCW----------------- 913
              +          GH                 +R+N     C+                 
Sbjct: 744  NSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHT 803

Query: 914  -YRNTSVSRADHSAAVENQ-LSGYLLRKFKNSHGWQKLWVVFTN---FCLFFYKTHQDDY 968
              R  S+     S A EN  +  +L    K   GW K W V        L+ Y   QD  
Sbjct: 804  PQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVK 863

Query: 969  PLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVI--QGASS 1026
               SLPL+G+ V  P   +   + +VFK+      ++F  E++    RWM V+   G   
Sbjct: 864  AQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGD 923

Query: 1027 SAGRAPSIVQD 1037
            +    P++ +D
Sbjct: 924  TFCPGPTLSED 934


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score =  139 bits (350), Expect = 1e-32
 Identities = 82/257 (31%), Positives = 147/257 (57%), Gaps = 16/257 (6%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           K +++RV  +D  +E F I+P   G+ L  QV K + L E  +FG+++ +++ Y  WL+ 
Sbjct: 3   KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61

Query: 102 MKPIIRQ-IRRPKNVVLRLAVKFFPPDPGQ-LQEEYTRYLFALQLKRDLLEERLTCADTT 159
            K + +Q +++   +  +   KFFP D  + L +E T+ LF LQ+K  +L + + C   T
Sbjct: 62  NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121

Query: 160 AALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQ----QHCL------EKILEFHQKHVG 209
           A LL S+ +Q++ GDY++ + +     N+ L  Q    QH L      E+I  +H++H G
Sbjct: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181

Query: 210 QTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINT---FN 266
               +S  + L+IA+ LEMYG+ +    +++GT++ L V  +G+ +++   K+     F 
Sbjct: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241

Query: 267 WSKVRKLSFKRKRFLIK 283
           WS++R +SF  K+F+IK
Sbjct: 242 WSEIRNISFNDKKFVIK 258


>gi|4505257 moesin [Homo sapiens]
          Length = 577

 Score =  135 bits (340), Expect = 2e-31
 Identities = 79/257 (30%), Positives = 150/257 (58%), Gaps = 16/257 (6%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           K + +RV  +D  +E F I+P   G+ L  QV K + L E  +FG+++Q+T+ +  WL+ 
Sbjct: 3   KTISVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61

Query: 102 MKPIIRQ-IRRPKNVVLRLAVKFFPPDPGQ-LQEEYTRYLFALQLKRDLLEERLTCADTT 159
            K +  Q +R+   ++ +   KF+P D  + L ++ T+ LF LQ+K  +L + + C   T
Sbjct: 62  NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121

Query: 160 AALLTSHLLQSEIGDYDETLDRE-HLKVNEYLPG---QQHCL------EKILEFHQKHVG 209
           A LL S+ +QS+ GD+++ + +  +L  ++ LP    +QH L      E+I  +H++H G
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181

Query: 210 QTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINT---FN 266
               ++  + L+IA+ LEMYG+ +    +++G+++ L V  +G+ +++   ++     F 
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241

Query: 267 WSKVRKLSFKRKRFLIK 283
           WS++R +SF  K+F+IK
Sbjct: 242 WSEIRNISFNDKKFVIK 258


>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
          Length = 1462

 Score =  133 bits (334), Expect = 1e-30
 Identities = 93/334 (27%), Positives = 164/334 (49%), Gaps = 22/334 (6%)

Query: 528  HKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVK---------EDAMPATLMTL 578
            HK      A  I +E+L++E+ Y++ L+ + + F  AV++          D +    +  
Sbjct: 885  HKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQ 944

Query: 579  LFSNIDPIYEFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQ 638
              S +  I++ H+G L E+E+RL+ WE         S Q++ D+ L   +      ++  
Sbjct: 945  GLSELPAIHDLHQGILEELEERLSNWE---------SQQKVADVFLAREQGFDHHATHIL 995

Query: 639  RHDEVLTELEKATKRCKKLEAVYKEFELQ-KVCYLPLNTFLLKPIQRLLHYRLLLRRLCG 697
            + D  L  L +      +L A  +EFE   +         LL+ +QRL  Y++LL     
Sbjct: 996  QFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLN 1055

Query: 698  HYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFI 757
            +  P   +Y +   AL  I++VT      + + ENLQKL  ++  + G  +L+ PGREF+
Sbjct: 1056 NLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFL 1115

Query: 758  REGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSV 817
            +EG L K+T K  + R  FL +D+LLYT     G   +R++  L +  M V     E  V
Sbjct: 1116 KEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDG--KYRLKNTLAVANMKVSRPVME-KV 1172

Query: 818  PHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAI 851
            P+   I  ++  ++++AS+  E+++W   L+ A+
Sbjct: 1173 PYALKIETSESCLMLSASSCAERDEWYGCLSRAL 1206



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 1/95 (1%)

Query: 932  LSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHK 991
            +SGYL R  +    W+KLW V     L+ Y   +D   L S+PLLG++++  +E      
Sbjct: 1366 ISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEV 1425

Query: 992  DYVFKLQFKSHVYF-FRAESKYTFERWMEVIQGAS 1025
              +F L  K  +++ F+AE   + +RW+E ++ AS
Sbjct: 1426 GPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460


>gi|161702986 ezrin [Homo sapiens]
          Length = 586

 Score =  128 bits (322), Expect = 2e-29
 Identities = 80/257 (31%), Positives = 141/257 (54%), Gaps = 16/257 (6%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           K +++RV  +D  +E F I+P   G+ L  QV K + L E  YFG+ + + + +  WL+ 
Sbjct: 3   KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61

Query: 102 MKPIIRQ-IRRPKNVVLRLAVKFFPPDPGQ-LQEEYTRYLFALQLKRDLLEERLTCADTT 159
            K +  Q +R+   +  +   KF+P D  + L ++ T+ LF LQ+K  +L + + C   T
Sbjct: 62  DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121

Query: 160 AALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQ----QHCL------EKILEFHQKHVG 209
           A LL S+ +Q++ GDY++ + +     +E L  Q    QH L      ++I  +H +H G
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181

Query: 210 QTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINT---FN 266
                +  + L+IA+ LEMYGI +    +++GT + L V  +G+ +++   K+     F 
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241

Query: 267 WSKVRKLSFKRKRFLIK 283
           WS++R +SF  K+F+IK
Sbjct: 242 WSEIRNISFNDKKFVIK 258


>gi|21614499 ezrin [Homo sapiens]
          Length = 586

 Score =  128 bits (322), Expect = 2e-29
 Identities = 80/257 (31%), Positives = 141/257 (54%), Gaps = 16/257 (6%)

Query: 42  KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
           K +++RV  +D  +E F I+P   G+ L  QV K + L E  YFG+ + + + +  WL+ 
Sbjct: 3   KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61

Query: 102 MKPIIRQ-IRRPKNVVLRLAVKFFPPDPGQ-LQEEYTRYLFALQLKRDLLEERLTCADTT 159
            K +  Q +R+   +  +   KF+P D  + L ++ T+ LF LQ+K  +L + + C   T
Sbjct: 62  DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121

Query: 160 AALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQ----QHCL------EKILEFHQKHVG 209
           A LL S+ +Q++ GDY++ + +     +E L  Q    QH L      ++I  +H +H G
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181

Query: 210 QTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINT---FN 266
                +  + L+IA+ LEMYGI +    +++GT + L V  +G+ +++   K+     F 
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241

Query: 267 WSKVRKLSFKRKRFLIK 283
           WS++R +SF  K+F+IK
Sbjct: 242 WSEIRNISFNDKKFVIK 258


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
           [Homo sapiens]
          Length = 1174

 Score =  124 bits (311), Expect = 5e-28
 Identities = 79/286 (27%), Positives = 139/286 (48%), Gaps = 15/286 (5%)

Query: 47  RVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPII 106
           R++LL+N    F +  +  GQ  L  V +RL L E  YF + + N Q+   W++  KP+ 
Sbjct: 26  RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLK 85

Query: 107 RQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTS 165
           +Q+ +      +   V F+ P   QLQ+E TRY + LQLK+D+LE  + C    A  L  
Sbjct: 86  KQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAG 145

Query: 166 HLLQSEIGDYDETLDREHLKVNEYLPGQQHCLEKILE--------FHQKHVGQTPAESDF 217
             +Q++ GD+D+   ++ L+     P      EK+LE         HQK+ G T  +++ 
Sbjct: 146 LAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEM 205

Query: 218 QVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLV-FQGTTKINTFNWSKVRKLSFK 276
             ++   +++ YG   + A D +G+ I +     G+ V  +       F W  +  +S  
Sbjct: 206 LYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHN 265

Query: 277 RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRL 322
           +  F ++L  +     ++T++F     +  K  W++CV  H F+RL
Sbjct: 266 KSFFALELANK-----EETIQFQTEDMETAKYIWRLCVARHKFYRL 306


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,773,189
Number of Sequences: 37866
Number of extensions: 2243021
Number of successful extensions: 13928
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 670
Number of HSP's that attempted gapping in prelim test: 11091
Number of HSP's gapped (non-prelim): 2797
length of query: 1054
length of database: 18,247,518
effective HSP length: 113
effective length of query: 941
effective length of database: 13,968,660
effective search space: 13144509060
effective search space used: 13144509060
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.