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Search of human proteins with 13449279
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
(299 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 602 e-172
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 122 3e-28
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 122 3e-28
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 115 6e-26
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 114 1e-25
gi|13899342 solute carrier [Homo sapiens] 107 1e-23
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 105 4e-23
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 105 6e-23
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 100 2e-21
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 100 2e-21
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 99 6e-21
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 98 8e-21
gi|115430257 solute carrier family 25, member 26 [Homo sapiens] 97 1e-20
gi|7706306 solute carrier family 25, member 39 isoform b [Homo s... 96 4e-20
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 96 4e-20
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 96 5e-20
gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 94 1e-19
gi|219555665 solute carrier family 25, member 39 isoform a [Homo... 93 3e-19
gi|46094065 mitochondrial carrier family protein [Homo sapiens] 89 4e-18
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade... 89 6e-18
gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 88 8e-18
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 87 1e-17
gi|27544933 solute carrier family 25, member 16 [Homo sapiens] 87 2e-17
gi|11225256 uncoupling protein 1 [Homo sapiens] 87 2e-17
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens] 86 5e-17
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 85 7e-17
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 85 7e-17
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 602 bits (1552), Expect = e-172
Identities = 299/299 (100%), Positives = 299/299 (100%)
Query: 1 MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSF 60
MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSF
Sbjct: 1 MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSF 60
Query: 61 RMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSG 120
RMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSG
Sbjct: 61 RMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSG 120
Query: 121 LTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHG 180
LTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHG
Sbjct: 121 LTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHG 180
Query: 181 VFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQP 240
VFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQP
Sbjct: 181 VFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQP 240
Query: 241 VPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW 299
VPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW
Sbjct: 241 VPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW 299
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 122 bits (307), Expect = 3e-28
Identities = 93/301 (30%), Positives = 144/301 (47%), Gaps = 19/301 (6%)
Query: 2 SAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCA---TDPNSYKSLVD 58
SA+P + V E++ + G AG V ++P+D+VKTR Q QR YK+ D
Sbjct: 317 SARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFD 376
Query: 59 SFRMIFQMEGLFGFYKGILPPILAETPKRAVKF----FTFEQYKKLLGYVSLSPALTFAI 114
F+ + + EG FG Y+G+LP +L P++A+K F +++ G V L+ + +
Sbjct: 377 CFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEI---L 433
Query: 115 AGLGSGLTEAIVVNPFEVVKVGLQ-ANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLT 173
AG +G ++ I NP E+VK+ LQ A T + S + R + G G+ KG
Sbjct: 434 AGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDL------GFFGIYKGAK 487
Query: 174 ATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKS 233
A R F+ +YF Y +VK N+D + G ++G A+ + P DV K+
Sbjct: 488 ACFLRDIPFSAIYFPCYAHVKASF-ANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKT 546
Query: 234 RIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYS 293
R+Q G+ Y + +EEG AL+KG ++ R P V LL YE
Sbjct: 547 RLQVAARA-GQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 605
Query: 294 W 294
W
Sbjct: 606 W 606
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 122 bits (307), Expect = 3e-28
Identities = 93/301 (30%), Positives = 144/301 (47%), Gaps = 19/301 (6%)
Query: 2 SAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCA---TDPNSYKSLVD 58
SA+P + V E++ + G AG V ++P+D+VKTR Q QR YK+ D
Sbjct: 318 SARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFD 377
Query: 59 SFRMIFQMEGLFGFYKGILPPILAETPKRAVKF----FTFEQYKKLLGYVSLSPALTFAI 114
F+ + + EG FG Y+G+LP +L P++A+K F +++ G V L+ + +
Sbjct: 378 CFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEI---L 434
Query: 115 AGLGSGLTEAIVVNPFEVVKVGLQ-ANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLT 173
AG +G ++ I NP E+VK+ LQ A T + S + R + G G+ KG
Sbjct: 435 AGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDL------GFFGIYKGAK 488
Query: 174 ATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKS 233
A R F+ +YF Y +VK N+D + G ++G A+ + P DV K+
Sbjct: 489 ACFLRDIPFSAIYFPCYAHVKASF-ANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKT 547
Query: 234 RIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYS 293
R+Q G+ Y + +EEG AL+KG ++ R P V LL YE
Sbjct: 548 RLQVAARA-GQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 606
Query: 294 W 294
W
Sbjct: 607 W 607
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 115 bits (287), Expect = 6e-26
Identities = 83/293 (28%), Positives = 140/293 (47%), Gaps = 19/293 (6%)
Query: 10 VREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQR---CATDPNSYKSLVDSFRMIFQM 66
+ E++ + G AG V ++P+D+VKTR Q QR YK+ D F+ + +
Sbjct: 323 IAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRY 382
Query: 67 EGLFGFYKGILPPILAETPKRAVKF----FTFEQYKKLLGYVSLSPALTFAIAGLGSGLT 122
EG FG Y+G++P ++ P++A+K F +++ + G V L + +AG +G +
Sbjct: 383 EGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEV---LAGGCAGGS 439
Query: 123 EAIVVNPFEVVKVGLQ-ANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGV 181
+ I NP E+VK+ LQ A T + S + R + G+ GL KG A R
Sbjct: 440 QVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDL------GIFGLYKGAKACFLRDIP 493
Query: 182 FNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPV 241
F+ +YF Y + K ++ +++ + G ++G A+ + P DV K+R+Q
Sbjct: 494 FSAIYFPVYAHCK-LLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARA 552
Query: 242 PGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSW 294
G+ Y + +EEG A +KG ++ R P V L+ YE W
Sbjct: 553 -GQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRW 604
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 114 bits (285), Expect = 1e-25
Identities = 87/301 (28%), Positives = 153/301 (50%), Gaps = 35/301 (11%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYK 74
+ I+AGG AG +EIC+ P + VKT+ Q+ + P Y+ + D R + G+ G Y+
Sbjct: 27 KAILAGGLAGGIEICITFPTEYVKTQLQLDE-RSHPPRYRGIGDCVRQTVRSHGVLGLYR 85
Query: 75 GILPPILAETPKRAVKFFTFE----QYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVN-P 129
G+ + PK AV+F FE + G + + L + GLG+G+ EA+VV P
Sbjct: 86 GLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGL---LCGLGAGVAEAVVVVCP 142
Query: 130 FEVVKVGLQANRNTFAEQPSTVGY---ARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVY 186
E +KV ++ + P G+ R+I++++G L+G +GLTAT+ + G +
Sbjct: 143 METIKVKFIHDQTS--PNPKYRGFFHGVREIVREQG--LKGTYQGLTATVLKQGSNQAIR 198
Query: 187 FGFYYNVKNMI-------PVNKDPILEFWRKFGI-GLLSGTIASVINIPFDVAKSRIQGP 238
F +++N P+N P++ G+ G ++G + N P DV K+R+QG
Sbjct: 199 FFVMTSLRNWYRGDNPNKPMN--PLIT-----GVFGAIAGAASVFGNTPLDVIKTRMQGL 251
Query: 239 QPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQEN 298
+ KYR + + ++EG+ A YKG +P++ R+ A++ ++Y+ L +
Sbjct: 252 EAH----KYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKV 307
Query: 299 W 299
W
Sbjct: 308 W 308
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 107 bits (267), Expect = 1e-23
Identities = 83/288 (28%), Positives = 135/288 (46%), Gaps = 29/288 (10%)
Query: 16 QIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKG 75
+++ GG AGLV + + P+D+ KTR Q Q YK ++D + EG FG Y+G
Sbjct: 11 KLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKA---MYKGMIDCLMKTARAEGFFGMYRG 67
Query: 76 ILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTF-AIAGLGSGLTEAIVVNPFEVVK 134
+ TP++A+K + +++LL + L +AG G+G+ + +V P E++K
Sbjct: 68 AAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKMEMLAGCGAGMCQVVVTCPMEMLK 127
Query: 135 VGLQ-ANRNTFAEQ----------------------PSTVGYARQIIKKEGWGLQGLNKG 171
+ LQ A R Q PS A ++++ + GL GL +G
Sbjct: 128 IQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQ--GLAGLYRG 185
Query: 172 LTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVA 231
L ATL R F+++YF + N+ N+ F F G ++G+IA+V P DV
Sbjct: 186 LGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVSGCVAGSIAAVAVTPLDVL 245
Query: 232 KSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGP 279
K+RIQ + GE Y ++ +EG A KG + + + P
Sbjct: 246 KTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGAGCRALVIAP 293
Score = 43.9 bits (102), Expect = 2e-04
Identities = 36/165 (21%), Positives = 72/165 (43%), Gaps = 25/165 (15%)
Query: 6 EVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQ--------IQRCATDPNSYKSLV 57
E + R +++AG AG+ ++ + P++++K + Q Q A+ P++ +S
Sbjct: 95 EDGMQRNLKMEMLAGCGAGMCQVVVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYT 154
Query: 58 DSFRM-------------IFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYV 104
+ + +GL G Y+G+ +L + P + F F LG+
Sbjct: 155 TGSASTHRRPSATLIAWELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFANLNN-LGFN 213
Query: 105 SLSPALTFA---IAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAE 146
L+ +FA ++G +G A+ V P +V+K +Q + E
Sbjct: 214 ELAGKASFAHSFVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGE 258
Score = 37.7 bits (86), Expect = 0.012
Identities = 20/62 (32%), Positives = 30/62 (48%)
Query: 14 SRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFY 73
+ V+G AG + + PLDV+KTR Q + + Y + D R ++ EG F
Sbjct: 222 AHSFVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFM 281
Query: 74 KG 75
KG
Sbjct: 282 KG 283
Score = 34.7 bits (78), Expect = 0.10
Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 7/88 (7%)
Query: 215 LLSGTIASVINI----PFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGL 270
L++G +A ++ + P D+AK+R+Q G+ Y+ + + EG +Y+G
Sbjct: 12 LINGGVAGLVGVTCVFPIDLAKTRLQNQH---GKAMYKGMIDCLMKTARAEGFFGMYRGA 68
Query: 271 LPKIMRLGPGGAVMLLVYEYTYSWLQEN 298
+ + P A+ L ++ L E+
Sbjct: 69 AVNLTLVTPEKAIKLAANDFFRRLLMED 96
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 105 bits (263), Expect = 4e-23
Identities = 93/299 (31%), Positives = 142/299 (47%), Gaps = 28/299 (9%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCAT--DPNSYKSLVDSFRMIFQMEGLFGF 72
+ ++AGG G+ + + HPLD VK R Q Q + P Y D FR EG+ G
Sbjct: 12 KNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGL 71
Query: 73 YKGILPPILAETPKRAVKFFTFEQYKKL--------LGYVSLSPALTFAIAGLGSGLTEA 124
Y+G+ PI+ TP AV FF F KKL L Y L FA AG+ SG+
Sbjct: 72 YRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQL-----FA-AGMLSGVFTT 125
Query: 125 IVVNPFEVVKVGLQANRNT-FAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFN 183
++ P E +K LQ ++ ++ T+ A+++ ++ +G++G+ KG TL R +
Sbjct: 126 GIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQE--FGIRGIYKGTVLTLMRDVPAS 183
Query: 184 MVYFGFYYNVKNMIPVNKDPILEFW--RKFGIGLLSGTIASVINIPFDVAKSRIQGPQPV 241
+YF Y +KN+ + E R G ++G + IP DV KSR Q P
Sbjct: 184 GMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPG 243
Query: 242 PGEIKYRTCFK-TMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW 299
KY F+ + + ++EG+ +LYKG ++R P A L +E +L NW
Sbjct: 244 ----KYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL--NW 296
Score = 50.4 bits (119), Expect = 2e-06
Identities = 35/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 5 PEVSLVREAS--RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRM 62
PE V E S R +VAGG AG+ + P DV+K+RFQ PN ++ D R
Sbjct: 199 PEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFR---DVLRE 255
Query: 63 IFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVS 105
+ + EG+ YKG ++ P A F FE K L + +
Sbjct: 256 LIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWAT 298
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 105 bits (261), Expect = 6e-23
Identities = 82/300 (27%), Positives = 132/300 (44%), Gaps = 31/300 (10%)
Query: 16 QIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKG 75
+++ GG AGL+ + + P+D+ KTR Q Q+ Y S+ D + EG FG Y+G
Sbjct: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQ--NGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
Query: 76 ILPPILAETPKRAVKFFTFEQYKKLLGYVSLS-PALTFAIAGLGSGLTEAIVVNPFEVVK 134
+ TP++A+K + ++ L L +AG G+G + IV P E++K
Sbjct: 69 AAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
Query: 135 VGLQ------ANRNTFAEQ--------------------PSTVGYARQIIKKEGWGLQGL 168
+ LQ A R A Q P+ R +++ G + GL
Sbjct: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRG--IAGL 186
Query: 169 NKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPF 228
KGL ATL R F++VYF + N+ + + F+ F G ++G+ A+V P
Sbjct: 187 YKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPC 246
Query: 229 DVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVY 288
DV K+R+Q Q E Y + + EG A KG + + + P + +VY
Sbjct: 247 DVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVY 306
Score = 34.7 bits (78), Expect = 0.10
Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 6/80 (7%)
Query: 215 LLSGTIASVINI----PFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGL 270
L++G IA +I + P D+AK+R+Q Q G+ Y + + + EG +Y+G
Sbjct: 12 LINGGIAGLIGVTCVFPIDLAKTRLQNQQN--GQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
Query: 271 LPKIMRLGPGGAVMLLVYEY 290
+ + P A+ L ++
Sbjct: 70 AVNLTLVTPEKAIKLAANDF 89
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 100 bits (248), Expect = 2e-21
Identities = 81/285 (28%), Positives = 135/285 (47%), Gaps = 18/285 (6%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPN----SYKSLVDSFRMIFQMEGLF 70
+ V GG A +V P+D+ KTR Q+Q + D Y+ + + I + EG+
Sbjct: 42 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 101
Query: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKL-LGYVSLSPALTFAIAGLGSGLTEAIVVNP 129
Y GI P +L + +K ++ K+L + + L I G+ SG+ + + NP
Sbjct: 102 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 161
Query: 130 FEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGF 189
+V+K+ +QA + F Q S +G I ++EG +GL +G+ T R + V
Sbjct: 162 TDVLKIRMQAQGSLF--QGSMIGSFIDIYQQEG--TRGLWRGVVPTAQRAAIVVGVELPV 217
Query: 190 YYNVKNMIPVNK---DPIL-EFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEI 245
Y K + ++ D IL F F GL +G +AS P DV ++R+ + + G +
Sbjct: 218 YDITKKHLILSGMMGDTILTHFVSSFTCGL-AGALASN---PVDVVRTRMMNQRAIVGHV 273
Query: 246 K-YRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
Y+ + +++ EG ALYKG P +RLGP + + YE
Sbjct: 274 DLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYE 318
Score = 54.7 bits (130), Expect = 1e-07
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 4/86 (4%)
Query: 208 WRKFGIGLLSGTIASVINIPFDVAKSRIQGP-QPVPG---EIKYRTCFKTMATVYQEEGI 263
W+ F G L+ +A P D+ K+R+Q Q + EIKYR F + + +EEG+
Sbjct: 41 WKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGV 100
Query: 264 LALYKGLLPKIMRLGPGGAVMLLVYE 289
LALY G+ P ++R G + + +Y+
Sbjct: 101 LALYSGIAPALLRQASYGTIKIGIYQ 126
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 18 VAGGSAGLVEICLMHPLDVVKTRFQIQRCATDP-NSYKSLVDSFRMIFQMEGLFGFYKGI 76
V+ + GL +P+DVV+TR QR + YK VD +++ EG F YKG
Sbjct: 240 VSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGF 299
Query: 77 LPPILAETPKRAVKFFTFEQYKKL 100
P L P + F T+EQ K+L
Sbjct: 300 WPNWLRLGPWNIIFFITYEQLKRL 323
Score = 49.7 bits (117), Expect = 3e-06
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 16/187 (8%)
Query: 112 FAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYAR------QIIKKEGWGL 165
F GL S + E P ++ K LQ + + + Y +I K+EG +
Sbjct: 44 FVYGGLASIVAE-FGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEG--V 100
Query: 166 QGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVN-KDPILEFWRKFGIGLLSGTIASVI 224
L G+ L R + + G Y ++K + +D L G++SG I+S I
Sbjct: 101 LALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLI--NMICGVVSGVISSTI 158
Query: 225 NIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVM 284
P DV K R+Q G + + + +YQ+EG L++G++P R V
Sbjct: 159 ANPTDVLKIRMQAQ----GSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVE 214
Query: 285 LLVYEYT 291
L VY+ T
Sbjct: 215 LPVYDIT 221
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 100 bits (248), Expect = 2e-21
Identities = 81/285 (28%), Positives = 135/285 (47%), Gaps = 18/285 (6%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPN----SYKSLVDSFRMIFQMEGLF 70
+ V GG A +V P+D+ KTR Q+Q + D Y+ + + I + EG+
Sbjct: 39 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 98
Query: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKL-LGYVSLSPALTFAIAGLGSGLTEAIVVNP 129
Y GI P +L + +K ++ K+L + + L I G+ SG+ + + NP
Sbjct: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 158
Query: 130 FEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGF 189
+V+K+ +QA + F Q S +G I ++EG +GL +G+ T R + V
Sbjct: 159 TDVLKIRMQAQGSLF--QGSMIGSFIDIYQQEG--TRGLWRGVVPTAQRAAIVVGVELPV 214
Query: 190 YYNVKNMIPVNK---DPIL-EFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEI 245
Y K + ++ D IL F F GL +G +AS P DV ++R+ + + G +
Sbjct: 215 YDITKKHLILSGMMGDTILTHFVSSFTCGL-AGALASN---PVDVVRTRMMNQRAIVGHV 270
Query: 246 K-YRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
Y+ + +++ EG ALYKG P +RLGP + + YE
Sbjct: 271 DLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYE 315
Score = 54.7 bits (130), Expect = 1e-07
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 4/86 (4%)
Query: 208 WRKFGIGLLSGTIASVINIPFDVAKSRIQGP-QPVPG---EIKYRTCFKTMATVYQEEGI 263
W+ F G L+ +A P D+ K+R+Q Q + EIKYR F + + +EEG+
Sbjct: 38 WKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGV 97
Query: 264 LALYKGLLPKIMRLGPGGAVMLLVYE 289
LALY G+ P ++R G + + +Y+
Sbjct: 98 LALYSGIAPALLRQASYGTIKIGIYQ 123
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 18 VAGGSAGLVEICLMHPLDVVKTRFQIQRCATDP-NSYKSLVDSFRMIFQMEGLFGFYKGI 76
V+ + GL +P+DVV+TR QR + YK VD +++ EG F YKG
Sbjct: 237 VSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGF 296
Query: 77 LPPILAETPKRAVKFFTFEQYKKL 100
P L P + F T+EQ K+L
Sbjct: 297 WPNWLRLGPWNIIFFITYEQLKRL 320
Score = 49.7 bits (117), Expect = 3e-06
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 16/187 (8%)
Query: 112 FAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYAR------QIIKKEGWGL 165
F GL S + E P ++ K LQ + + + Y +I K+EG +
Sbjct: 41 FVYGGLASIVAE-FGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEG--V 97
Query: 166 QGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVN-KDPILEFWRKFGIGLLSGTIASVI 224
L G+ L R + + G Y ++K + +D L G++SG I+S I
Sbjct: 98 LALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLI--NMICGVVSGVISSTI 155
Query: 225 NIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVM 284
P DV K R+Q G + + + +YQ+EG L++G++P R V
Sbjct: 156 ANPTDVLKIRMQAQ----GSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVE 211
Query: 285 LLVYEYT 291
L VY+ T
Sbjct: 212 LPVYDIT 218
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 98.6 bits (244), Expect = 6e-21
Identities = 77/282 (27%), Positives = 125/282 (44%), Gaps = 11/282 (3%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPN----SYKSLVDSFRMIFQMEGLF 70
+ V GG A + C P+D+ KTR QIQ D Y+ ++ + I + EGL
Sbjct: 7 KPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLK 66
Query: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTF-AIAGLGSGLTEAIVVNP 129
Y GI P +L + +K T++ K+L L I G+ SG+ + + NP
Sbjct: 67 ALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTIANP 126
Query: 130 FEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGF 189
+V+K+ +QA NT Q +G I ++EG +GL KG++ T R + V
Sbjct: 127 TDVLKIRMQAQSNTI--QGGMIGNFMNIYQQEG--TRGLWKGVSLTAQRAAIVVGVELPV 182
Query: 190 YYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPV-PGEIK-Y 247
Y K + ++ + F G ++ + P DV ++R+ + + G Y
Sbjct: 183 YDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCSGY 242
Query: 248 RTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
+ ++ EG ALYKG P +RLGP + + YE
Sbjct: 243 TGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYE 284
Score = 49.3 bits (116), Expect = 4e-06
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 22 SAGLVEICLMHPLDVVKTRFQIQRCATDP--NSYKSLVDSFRMIFQMEGLFGFYKGILPP 79
+ GL +P+DVV+TR QR D + Y +D ++ EG F YKG P
Sbjct: 209 TCGLAGALASNPVDVVRTRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPN 268
Query: 80 ILAETPKRAVKFFTFEQYKKL 100
L P + F T+EQ KKL
Sbjct: 269 WLRLGPWNIIFFVTYEQLKKL 289
Score = 48.5 bits (114), Expect = 7e-06
Identities = 44/186 (23%), Positives = 78/186 (41%), Gaps = 12/186 (6%)
Query: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGI 76
++ G +G++ + +P DV+K R Q Q ++ +F I+Q EG G +KG+
Sbjct: 110 VICGILSGVISSTIANPTDVLKIRMQAQSNTIQGG----MIGNFMNIYQQEGTRGLWKGV 165
Query: 77 LPPILAETPKRAVKFFTFEQYKK--LLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVK 134
V+ ++ KK +L + T ++ GL A+ NP +VV+
Sbjct: 166 SLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVR 225
Query: 135 VGLQANR----NTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFY 190
+ R + T+ Q K EG+ L KG R G +N+++F Y
Sbjct: 226 TRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFF--ALYKGFWPNWLRLGPWNIIFFVTY 283
Query: 191 YNVKNM 196
+K +
Sbjct: 284 EQLKKL 289
Score = 45.4 bits (106), Expect = 6e-05
Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 4/86 (4%)
Query: 208 WRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPG----EIKYRTCFKTMATVYQEEGI 263
W+ F G L+ A P D+ K+R+Q EI+YR + + +EEG+
Sbjct: 6 WKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGL 65
Query: 264 LALYKGLLPKIMRLGPGGAVMLLVYE 289
ALY G+ P ++R G + + Y+
Sbjct: 66 KALYSGIAPAMLRQASYGTIKIGTYQ 91
Score = 45.4 bits (106), Expect = 6e-05
Identities = 51/187 (27%), Positives = 77/187 (41%), Gaps = 16/187 (8%)
Query: 112 FAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQI-----IKKEGWGLQ 166
F GL S +T P ++ K LQ T + + Y + I +E GL+
Sbjct: 9 FVYGGLAS-ITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREE-GLK 66
Query: 167 GLNKGLTATLGRHGVFNMVYFGFYYNVKNM-IPVNKDPILEFWRKFGIGLLSGTIASVIN 225
L G+ + R + + G Y ++K + I +D L G+LSG I+S I
Sbjct: 67 ALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPI--NVICGILSGVISSTIA 124
Query: 226 IPFDVAKSRIQGPQ-PVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVM 284
P DV K R+Q + G + +YQ+EG L+KG+ R V
Sbjct: 125 NPTDVLKIRMQAQSNTIQGGM-----IGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVE 179
Query: 285 LLVYEYT 291
L VY+ T
Sbjct: 180 LPVYDIT 186
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 98.2 bits (243), Expect = 8e-21
Identities = 72/285 (25%), Positives = 131/285 (45%), Gaps = 11/285 (3%)
Query: 6 EVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQ 65
E ++ + + G +G L PLD++KTR Q + + + ++ + +
Sbjct: 20 ETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVR 79
Query: 66 MEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAI 125
E L G +KG+ P I+ P + F T K+ AL + G+GS +
Sbjct: 80 TESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGV 139
Query: 126 VVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMV 185
++P V+K ++ + + S R I EG +GL GLTATL R F+ +
Sbjct: 140 CMSPITVIKTRYESGKYGYE---SIYAALRSIYHSEGH--RGLFSGLTATLLRDAPFSGI 194
Query: 186 YFGFYYNVKNMIPVNK-DPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGE 244
Y FY KN++P ++ D L F G+ +G +AS++ P DV K+ +Q
Sbjct: 195 YLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQ-----LYP 249
Query: 245 IKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
+K++ + + ++++ G+ ++G +P+ +R A+ VYE
Sbjct: 250 LKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
Score = 57.0 bits (136), Expect = 2e-08
Identities = 49/194 (25%), Positives = 83/194 (42%), Gaps = 23/194 (11%)
Query: 106 LSPALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYAR--------QI 157
L P + + G SG ++ P +++K LQ QPS G R ++
Sbjct: 24 LHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTL------QPSDHGSRRVGMLAVLLKV 77
Query: 158 IKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLS 217
++ E L GL KG++ ++ R +YFG Y++K P G+G S
Sbjct: 78 VRTES--LLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVG--S 133
Query: 218 GTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRL 277
++A V P V K+R + G+ Y + + + ++Y EG L+ GL ++R
Sbjct: 134 RSVAGVCMSPITVIKTRYES-----GKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRD 188
Query: 278 GPGGAVMLLVYEYT 291
P + L+ Y T
Sbjct: 189 APFSGIYLMFYNQT 202
Score = 39.3 bits (90), Expect = 0.004
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 23 AGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILA 82
AG++ + P DV+KT Q+ P ++ + + +IF+ GL GF++G +P L
Sbjct: 227 AGILASLVTQPADVIKTHMQLY-----PLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALR 281
Query: 83 ETPKRAVKFFTFEQYKKLLGYVS 105
T A+ + +E+ +G S
Sbjct: 282 RTLMAAMAWTVYEEMMAKMGLKS 304
>gi|115430257 solute carrier family 25, member 26 [Homo sapiens]
Length = 274
Score = 97.4 bits (241), Expect = 1e-20
Identities = 76/287 (26%), Positives = 128/287 (44%), Gaps = 34/287 (11%)
Query: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGI 76
+VAGG AG+ ++ PLD +KTR Q P + + G G Y G+
Sbjct: 10 LVAGGVAGVSVDLILFPLDTIKTRLQ------SPQGFN----------KAGGFHGIYAGV 53
Query: 77 LPPILAETPKRAVKFFTFEQYKKLLGYVSLS--PALTFAIAGLGSGLTEAIVVNPFEVVK 134
+ P A F T+E K L S S + +A + ++ P EVVK
Sbjct: 54 PSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVK 113
Query: 135 VGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVK 194
Q + +T T I+ +EG +QGL +G +T+ R F++V F + ++K
Sbjct: 114 QRAQVSAST-----RTFQIFSNILYEEG--IQGLYRGYKSTVLREIPFSLVQFPLWESLK 166
Query: 195 NMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQ----GPQPVPGEIKYRTC 250
+ +D +++ W+ G +G A+ + P DVAK+RI G G +
Sbjct: 167 ALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNV----- 221
Query: 251 FKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQE 297
+ V++ +G+ L+ G+ P++ + GG + L Y+ T+S L E
Sbjct: 222 LSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLE 268
Score = 32.3 bits (72), Expect = 0.52
Identities = 19/73 (26%), Positives = 36/73 (49%), Gaps = 1/73 (1%)
Query: 10 VREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGL 69
V ++ + V G AG + PLDV KTR + + A + +++ +++ +GL
Sbjct: 176 VVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAK-AGSSTADGNVLSVLHGVWRSQGL 234
Query: 70 FGFYKGILPPILA 82
G + G+ P + A
Sbjct: 235 AGLFAGVFPRMAA 247
>gi|7706306 solute carrier family 25, member 39 isoform b [Homo
sapiens]
Length = 351
Score = 95.9 bits (237), Expect = 4e-20
Identities = 87/337 (25%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQR----------------------------- 45
+Q+VA G+ +V M PLDVVK R Q QR
Sbjct: 13 QQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLSYTKWKCLLYCNG 72
Query: 46 -------------CAT---DPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAV 89
CAT DP + +D+F I + EG + G+ ++ P A+
Sbjct: 73 VLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGTRTLWSGLPATLVMTVPATAI 132
Query: 90 KFFTFEQYKKLL-GYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQP 148
F ++Q K L G S +AG + L V++P E+++ LQA ++ E
Sbjct: 133 YFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELG 192
Query: 149 STVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMI----PVNKDPI 204
+ V R + + GW L G TA R F+ +Y+ Y VK+ + P ++ +
Sbjct: 193 ACV---RTAVAQGGWRSLWLGWGPTAL--RDVPFSALYWFNYELVKSWLNGFRPKDQTSV 247
Query: 205 LEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYR-----TCFKTMATVYQ 259
F G +SGT+A+V+ +PFDV K++ Q ++ + + + +
Sbjct: 248 ---GMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRA 304
Query: 260 EEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQ 296
E G L+ G LP+I++ P A+M+ YE+ S+ Q
Sbjct: 305 ESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQ 341
Score = 45.8 bits (107), Expect = 5e-05
Identities = 37/135 (27%), Positives = 60/135 (44%), Gaps = 10/135 (7%)
Query: 8 SLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQME 67
+L + +VAG A L + ++ PL++++T+ Q Q SY+ L R
Sbjct: 148 ALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHV-----SYRELGACVRTAVAQG 202
Query: 68 GLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYV----SLSPALTFAIAGLGSGLTE 123
G + G P L + P A+ +F +E K L S ++F G+ SG
Sbjct: 203 GWRSLWLGWGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGI-SGTVA 261
Query: 124 AIVVNPFEVVKVGLQ 138
A++ PF+VVK Q
Sbjct: 262 AVLTLPFDVVKTQRQ 276
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 95.9 bits (237), Expect = 4e-20
Identities = 76/285 (26%), Positives = 133/285 (46%), Gaps = 14/285 (4%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNS---YKSLVDSFRMIFQMEGLFG 71
+ ++AGG A V + P++ VK Q+Q + + YK +VD I + +G F
Sbjct: 22 KDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFS 81
Query: 72 FYKGILPPILAETPKRAVKFFTFEQYKKLL--GYVSLSPALTFAIAGLGS----GLTEAI 125
F++G L ++ P +A+ F ++YK+L G + +A L S G T
Sbjct: 82 FWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLC 141
Query: 126 VVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIK-KEGWGLQGLNKGLTATLGRHGVFNM 184
VV P + + L + E+ G I+K + G+ GL +G ++ V+
Sbjct: 142 VVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYRA 201
Query: 185 VYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGE 244
YFG Y VK ++P K F F I + T + +++ PFD + R+ Q +
Sbjct: 202 SYFGAYDTVKGLLP--KPKKTPFLVSFFIAQVVTTCSGILSYPFDTVRRRMM-MQSGEAK 258
Query: 245 IKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
+Y+ +YQ EGI + ++G ++R G GGA++L++Y+
Sbjct: 259 RQYKGTLDCFVKIYQHEGISSFFRGAFSNVLR-GTGGALVLVLYD 302
>gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
Length = 314
Score = 95.5 bits (236), Expect = 5e-20
Identities = 81/300 (27%), Positives = 133/300 (44%), Gaps = 21/300 (7%)
Query: 1 MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSF 60
+ KP S S + + GG AG+ + PLD+VK R Q+ YK+ +
Sbjct: 12 IDGKPRTS---PKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHAL 68
Query: 61 RMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQ-YKKLLGYVSLSPA-LTFAIAGLG 118
I + EGL G Y G+ +L + + + +++L G P L A+ G+
Sbjct: 69 TSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMT 128
Query: 119 SGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYAR------QIIKKEGWGLQGLNKGL 172
+G T A V P EV + + A+ A+Q GY +I ++EG + L +G
Sbjct: 129 AGATGAFVGTPAEVALIRMTADGRLPADQRR--GYKNVFNALIRITREEG--VLTLWRGC 184
Query: 173 TATLGRHGVFNMVYFGFYYNVKNMIPVN---KDPILEFWRKFGIGLLSGTIASVINIPFD 229
T+ R V N Y K + + D IL F ++SG + + ++P D
Sbjct: 185 IPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNIL---CHFCASMISGLVTTAASMPVD 241
Query: 230 VAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
+AK+RIQ + + G+ +Y+ + V + EG +L+KG P RLGP + + E
Sbjct: 242 IAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLE 301
Score = 59.3 bits (142), Expect = 4e-09
Identities = 47/194 (24%), Positives = 87/194 (44%), Gaps = 7/194 (3%)
Query: 109 ALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRN--TFAEQPSTVGYARQIIKKEGWGLQ 166
++ F GL +G+ + V P ++VK +Q + E ++ I+K EG L+
Sbjct: 22 SVKFLFGGL-AGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEG--LR 78
Query: 167 GLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINI 226
G+ GL+A L R + G Y + + F K IG+ +G + +
Sbjct: 79 GIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGT 138
Query: 227 PFDVAKSRIQGPQPVPGEIK--YRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVM 284
P +VA R+ +P + + Y+ F + + +EEG+L L++G +P + R A
Sbjct: 139 PAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQ 198
Query: 285 LLVYEYTYSWLQEN 298
L Y + +L ++
Sbjct: 199 LASYSQSKQFLLDS 212
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/85 (30%), Positives = 36/85 (42%)
Query: 23 AGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILA 82
+GLV P+D+ KTR Q R YK+ +D + + EG F +KG P
Sbjct: 229 SGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYAR 288
Query: 83 ETPKRAVKFFTFEQYKKLLGYVSLS 107
P + F EQ K + LS
Sbjct: 289 LGPHTVLTFIFLEQMNKAYKRLFLS 313
>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
Length = 323
Score = 94.4 bits (233), Expect = 1e-19
Identities = 84/296 (28%), Positives = 137/296 (46%), Gaps = 22/296 (7%)
Query: 13 ASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCAT---------DPNSYKSLVDSFRMI 63
AS+ +++G +A + E+ PLD+ KTR Q+Q A + Y+ +V + I
Sbjct: 20 ASKFLLSGCAATVAELATF-PLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGI 78
Query: 64 FQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLS---PALTFAIAGLGSG 120
+ EG ++G+ P I + T+E ++++ S P I G+ +G
Sbjct: 79 IEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAG 138
Query: 121 LTEAIVVNPFEVVKVGLQANRNTFAEQPST----VGYARQIIKKEGWGLQGLNKGLTATL 176
+ + NP ++VKV +Q E V +A I EG G++GL G +
Sbjct: 139 VIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEG-GIRGLWAGWVPNI 197
Query: 177 GRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIG-LLSGTIASVINIPFDVAKSRI 235
R + NM Y VK+ + +N P+ + G+ L SG +AS++ P DV KSRI
Sbjct: 198 QRAALVNMGDLTTYDTVKHYLVLNT-PLEDNIMTHGLSSLCSGLVASILGTPADVIKSRI 256
Query: 236 QG-PQPVPGE-IKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
P+ G + Y++ + Q EG ++LYKG LP +R+ P V L YE
Sbjct: 257 MNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYE 312
Score = 44.3 bits (103), Expect = 1e-04
Identities = 29/82 (35%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
Query: 23 AGLVEICLMHPLDVVKTRFQIQRCATDPNS--YKSLVDSFRMIFQMEGLFGFYKGILPPI 80
+GLV L P DV+K+R Q YKS D Q EG YKG LP
Sbjct: 238 SGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSW 297
Query: 81 LAETPKRAVKFFTFEQYKKLLG 102
L TP V + T+E+ +++ G
Sbjct: 298 LRMTPWSMVFWLTYEKIREMSG 319
Score = 42.4 bits (98), Expect = 5e-04
Identities = 45/197 (22%), Positives = 85/197 (43%), Gaps = 15/197 (7%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQ---RCATDPNSYKSLVDSFRMIFQMEGLFG 71
+ ++ G AG++ L +P D+VK + Q++ + P ++ + +F I G+ G
Sbjct: 129 KSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRG 188
Query: 72 FYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPA----LTFAIAGLGSGLTEAIVV 127
+ G +P I T++ K L V +P +T ++ L SGL +I+
Sbjct: 189 LWAGWVPNIQRAALVNMGDLTTYDTVKHYL--VLNTPLEDNIMTHGLSSLCSGLVASILG 246
Query: 128 NPFEVVKVGLQANRNTFAEQPSTVGYARQ----IIKKEGWGLQGLNKGLTATLGRHGVFN 183
P +V+K + +Q + Y I +G G L KG + R ++
Sbjct: 247 TPADVIKSRIMNQPRD--KQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWS 304
Query: 184 MVYFGFYYNVKNMIPVN 200
MV++ Y ++ M V+
Sbjct: 305 MVFWLTYEKIREMSGVS 321
Score = 39.7 bits (91), Expect = 0.003
Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 20/104 (19%)
Query: 203 PILEFWRKFGIGLLSG---TIASVINIPFDVAKSRIQGPQPVPGEIK------------- 246
P+ + W + LLSG T+A + P D+ K+R+Q + GE
Sbjct: 12 PLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQ----MQGEAALARLGDGARESAP 67
Query: 247 YRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEY 290
YR +T + +EEG L L++G+ P I R ++ YE+
Sbjct: 68 YRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEH 111
>gi|219555665 solute carrier family 25, member 39 isoform a [Homo
sapiens]
Length = 359
Score = 92.8 bits (229), Expect = 3e-19
Identities = 87/345 (25%), Positives = 143/345 (41%), Gaps = 71/345 (20%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQR----------------------------- 45
+Q+VA G+ +V M PLDVVK R Q QR
Sbjct: 13 QQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLSYTKLPSSLQSTG 72
Query: 46 ---------------------CAT---DPNSYKSLVDSFRMIFQMEGLFGFYKGILPPIL 81
CAT DP + +D+F I + EG + G+ ++
Sbjct: 73 KCLLYCNGVLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGTRTLWSGLPATLV 132
Query: 82 AETPKRAVKFFTFEQYKKLL-GYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKVGLQAN 140
P A+ F ++Q K L G S +AG + L V++P E+++ LQA
Sbjct: 133 MTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQ 192
Query: 141 RNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMI--- 197
++ E + V R + + GW L G TA R F+ +Y+ Y VK+ +
Sbjct: 193 HVSYRELGACV---RTAVAQGGWRSLWLGWGPTAL--RDVPFSALYWFNYELVKSWLNGF 247
Query: 198 -PVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYR-----TCF 251
P ++ + F G +SGT+A+V+ +PFDV K++ Q ++ + +
Sbjct: 248 RPKDQTSV---GMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTW 304
Query: 252 KTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQ 296
+ + E G L+ G LP+I++ P A+M+ YE+ S+ Q
Sbjct: 305 LLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQ 349
Score = 45.8 bits (107), Expect = 5e-05
Identities = 37/135 (27%), Positives = 60/135 (44%), Gaps = 10/135 (7%)
Query: 8 SLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQME 67
+L + +VAG A L + ++ PL++++T+ Q Q SY+ L R
Sbjct: 156 ALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHV-----SYRELGACVRTAVAQG 210
Query: 68 GLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYV----SLSPALTFAIAGLGSGLTE 123
G + G P L + P A+ +F +E K L S ++F G+ SG
Sbjct: 211 GWRSLWLGWGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGI-SGTVA 269
Query: 124 AIVVNPFEVVKVGLQ 138
A++ PF+VVK Q
Sbjct: 270 AVLTLPFDVVKTQRQ 284
>gi|46094065 mitochondrial carrier family protein [Homo sapiens]
Length = 338
Score = 89.4 bits (220), Expect = 4e-18
Identities = 72/320 (22%), Positives = 145/320 (45%), Gaps = 43/320 (13%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQR-------------------CATD------ 49
+Q++A + ++ ++ PLDVVK R Q Q C +
Sbjct: 17 QQMLASCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNGLMDHLCVCEEGGNKL 76
Query: 50 ----PNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLL-GYV 104
P +++ +D+F I + EG+ + G+ P ++ P + F ++Q LL +
Sbjct: 77 WYKKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALLRSKL 136
Query: 105 SLSPALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWG 164
+ +AG+ + V++P E+++ +Q+ + ++ E V + + ++GW
Sbjct: 137 GENETCIPIVAGIVARFGAVTVISPLELIRTKMQSKKFSYVELHRFVS---KKVSEDGW- 192
Query: 165 LQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILE--FWRKFGIGLLSGTIAS 222
L +G T+ R F+ +Y+ Y +K + K + E F F G LSG+ A+
Sbjct: 193 -ISLWRGWAPTVLRDVPFSAMYWYNYEILKKWL-CEKSGLYEPTFMINFTSGALSGSFAA 250
Query: 223 VINIPFDVAKSRIQGPQPVPGEIK-----YRTCFKTMATVYQEEGILALYKGLLPKIMRL 277
V +PFDV K++ Q K + + + M + + G L+ GL+P+++++
Sbjct: 251 VATLPFDVVKTQKQTQLWTYESHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLIKI 310
Query: 278 GPGGAVMLLVYEYTYSWLQE 297
P A+M+ YE+ ++ Q+
Sbjct: 311 APACAIMISTYEFGKAFFQK 330
>gi|55749577 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 4 [Homo
sapiens]
Length = 298
Score = 88.6 bits (218), Expect = 6e-18
Identities = 75/286 (26%), Positives = 130/286 (45%), Gaps = 14/286 (4%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNS---YKSLVDSFRMIFQMEGLFG 71
+ +AGG A V + P++ VK Q+Q + ++ YK ++D I + +G
Sbjct: 10 KDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLS 69
Query: 72 FYKGILPPILAETPKRAVKFFTFEQYKKL-LGYVSLSPALTFAIAGL-----GSGLTEAI 125
F++G L ++ P +A+ F ++YK+L LG V AG +G T
Sbjct: 70 FWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLC 129
Query: 126 VVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIK-KEGWGLQGLNKGLTATLGRHGVFNM 184
V P + + L A+ A Q G IIK + GL+GL +G ++ ++
Sbjct: 130 FVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRA 189
Query: 185 VYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPG- 243
YFG Y K M+P K+ + + + I +A +++ PFD + R+ G
Sbjct: 190 AYFGVYDTAKGMLPDPKN--VHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGA 247
Query: 244 EIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
+I Y + ++EG A +KG ++R G GGA +L++Y+
Sbjct: 248 DIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLR-GMGGAFVLVLYD 292
>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
Length = 298
Score = 88.2 bits (217), Expect = 8e-18
Identities = 72/288 (25%), Positives = 131/288 (45%), Gaps = 16/288 (5%)
Query: 14 SRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATD---PNSYKSLVDSFRMIFQMEGLF 70
++ +AGG A + + P++ VK Q+Q + YK +VD I + +G+
Sbjct: 9 AKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVL 68
Query: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKL-LGYVSLSPALTFAIAGL-----GSGLTEA 124
F++G L ++ P +A+ F ++YK++ LG V AG +G T
Sbjct: 69 SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128
Query: 125 IVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIK-KEGWGLQGLNKGLTATLGRHGVFN 183
V P + + L A+ + G ++K + G++GL +G + ++ ++
Sbjct: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
Query: 184 MVYFGFYYNVKNMIPVNKDP-ILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVP 242
YFG Y K M+P K+ I+ W I +A V++ PFD + R+
Sbjct: 189 AAYFGVYDTAKGMLPDPKNTHIVVSWM---IAQTVTAVAGVVSYPFDTVRRRMMMQSGRK 245
Query: 243 G-EIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
G +I Y ++++EG A +KG ++R G GGA +L++Y+
Sbjct: 246 GADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYD 292
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 87.4 bits (215), Expect = 1e-17
Identities = 72/266 (27%), Positives = 119/266 (44%), Gaps = 9/266 (3%)
Query: 18 VAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGIL 77
+AG + G+ + + HP D VK R Q+Q + + Y+ + F+ I + E + G YKG+
Sbjct: 6 LAGCAGGVAGVLVGHPFDTVKVRLQVQ--SVEKPQYRGTLHCFKSIIKQESVLGLYKGLG 63
Query: 78 PPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKVGL 137
P++ T A+ F + LG+ S L +AG +G + ++ P E+ K L
Sbjct: 64 SPLMGLTFINALVFGVQGNTLRALGHDS---PLNQFLAGAAAGAIQCVICCPMELAKTRL 120
Query: 138 Q-ANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNM 196
Q + ++ QI E GL+G+N+G+ +TL R VYF Y +
Sbjct: 121 QLQDAGPARTYKGSLDCLAQIYGHE--GLRGVNRGMVSTLLRETPSFGVYFLTYDALTRA 178
Query: 197 IPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMAT 256
+ L + G SG ++ + P DV KSR+Q + G +YR +
Sbjct: 179 LGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQA-DGLRGAPRYRGILDCVHQ 237
Query: 257 VYQEEGILALYKGLLPKIMRLGPGGA 282
Y+ EG +GL ++R P A
Sbjct: 238 SYRAEGWRVFTRGLASTLLRAFPVNA 263
Score = 71.6 bits (174), Expect = 8e-13
Identities = 54/175 (30%), Positives = 84/175 (48%), Gaps = 6/175 (3%)
Query: 16 QIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKG 75
Q +AG +AG ++ + P+++ KTR Q+Q A +YK +D I+ EGL G +G
Sbjct: 95 QFLAGAAAGAIQCVICCPMELAKTRLQLQD-AGPARTYKGSLDCLAQIYGHEGLRGVNRG 153
Query: 76 ILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALT--FAIAGLGSGLTEAIVVNPFEVV 133
++ +L ETP V F T++ + LG L +AG SG+ + P +VV
Sbjct: 154 MVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVV 213
Query: 134 KVGLQANRNTFAEQ-PSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYF 187
K LQA+ A + + Q + EGW + +GL +TL R N F
Sbjct: 214 KSRLQADGLRGAPRYRGILDCVHQSYRAEGWRV--FTRGLASTLLRAFPVNAATF 266
Score = 66.2 bits (160), Expect = 3e-11
Identities = 53/181 (29%), Positives = 85/181 (46%), Gaps = 9/181 (4%)
Query: 109 ALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGL 168
AL F +AG G+ +V +PF+ VKV LQ + T+ + IIK+E + GL
Sbjct: 2 ALDF-LAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQE--SVLGL 58
Query: 169 NKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPF 228
KGL + L N + FG N + + P+ +F G +G I VI P
Sbjct: 59 YKGLGSPLMGLTFINALVFGVQGNTLRALG-HDSPL----NQFLAGAAAGAIQCVICCPM 113
Query: 229 DVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVY 288
++AK+R+Q P Y+ +A +Y EG+ + +G++ ++R P V L Y
Sbjct: 114 ELAKTRLQLQDAGPAR-TYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTY 172
Query: 289 E 289
+
Sbjct: 173 D 173
>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
Length = 332
Score = 87.0 bits (214), Expect = 2e-17
Identities = 86/292 (29%), Positives = 126/292 (43%), Gaps = 23/292 (7%)
Query: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSL--VDSFRMIFQMEGLFGF 72
R +AGG AG + PLD VK Q + YK L + R + Q EG G
Sbjct: 38 RSFLAGGIAGCCAKTTVAPLDRVKVLLQAHN-----HHYKHLGVFSALRAVPQKEGFLGL 92
Query: 73 YKGILPPILAETPKRAVKFFTFEQYKKLL-GYVSLSPALTFAIAGLGSGLTEAIVVNPFE 131
YKG ++ P A++F FE YK L+ + +S + +AG +G+T I P +
Sbjct: 93 YKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLD 152
Query: 132 VVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYY 191
+V+V L + + I KEG G G +GL T+ + V F +
Sbjct: 153 MVRVRLAFQVKGEHSYTGIIHAFKTIYAKEG-GFFGFYRGLMPTILGMAPYAGVSFFTFG 211
Query: 192 NVKNM----------IPVNKDP---ILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGP 238
+K++ P + +P +L+ G ++G IA I+ PFDV + R+Q
Sbjct: 212 TLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLG 271
Query: 239 QPVPGEIKYRTCFKTMATVYQEEGI-LALYKGLLPKIMRLGPGGAVMLLVYE 289
+P K T TM VY GI LY+GL +R P AV YE
Sbjct: 272 TVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYE 323
Score = 40.8 bits (94), Expect = 0.001
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 4/85 (4%)
Query: 207 FW-RKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILA 265
+W R F G ++G A P D K +Q K+ F + V Q+EG L
Sbjct: 35 YWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNH---HYKHLGVFSALRAVPQKEGFLG 91
Query: 266 LYKGLLPKIMRLGPGGAVMLLVYEY 290
LYKG ++R+ P GA+ + +E+
Sbjct: 92 LYKGNGAMMIRIFPYGAIQFMAFEH 116
Score = 40.8 bits (94), Expect = 0.001
Identities = 26/99 (26%), Positives = 48/99 (48%), Gaps = 2/99 (2%)
Query: 2 SAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFR 61
S P V LV + ++ GG AG + + +P DV + R Q+ + ++ D+ +
Sbjct: 230 SDNPNV-LVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMK 288
Query: 62 MIFQMEGL-FGFYKGILPPILAETPKRAVKFFTFEQYKK 99
++ G+ G Y+G+ + P +AV F T+E K+
Sbjct: 289 YVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 86.7 bits (213), Expect = 2e-17
Identities = 78/280 (27%), Positives = 123/280 (43%), Gaps = 11/280 (3%)
Query: 16 QIVAGGSAGLVEICLMHPLDVVKTRFQIQ-RCATDPN-SYKSLVDSFRMIFQMEGLFGFY 73
Q+ + G A + + PLD K R Q+Q C T YK ++ + + + EG Y
Sbjct: 16 QLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLY 75
Query: 74 KGILPPILAETPKRAVKFFTFEQYKKLL-GYVSLSPALTFAI-AGLGSGLTEAIVVNPFE 131
G+ + + +++ ++ ++ L +P+L I AGL +G + P E
Sbjct: 76 SGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTE 135
Query: 132 VVKVGLQANRNTFAEQPSTVG-YARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFY 190
VVKV LQA + +P G Y I GL GL KG T L R + N Y
Sbjct: 136 VVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTY 195
Query: 191 YNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSR-IQGPQPVPGEIKYRT 249
+K N + L++G A+ ++ P DV K+R I P PG+ Y++
Sbjct: 196 DLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSP---PGQ--YKS 250
Query: 250 CFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
V+ EG A +KGL+P +RLG +M + +E
Sbjct: 251 VPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFE 290
Score = 48.9 bits (115), Expect = 5e-06
Identities = 29/85 (34%), Positives = 42/85 (49%), Gaps = 4/85 (4%)
Query: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGI 76
+V+ AG + P+DVVKTRF + P YKS+ + +F EG F+KG+
Sbjct: 216 LVSALIAGFCATAMSSPVDVVKTRF----INSPPGQYKSVPNCAMKVFTNEGPTAFFKGL 271
Query: 77 LPPILAETPKRAVKFFTFEQYKKLL 101
+P L + F FEQ K+ L
Sbjct: 272 VPSFLRLGSWNVIMFVCFEQLKREL 296
Score = 41.6 bits (96), Expect = 9e-04
Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Query: 216 LSGTIASVINIPFDVAKSR--IQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPK 273
++ +A VI P D AK R +QG P I+Y+ T+ V + EG + LY GL
Sbjct: 22 IAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAG 81
Query: 274 IMRLGPGGAVMLLVYEYTYSWL 295
+ R ++ + +Y+ +L
Sbjct: 82 LQRQISSASLRIGLYDTVQEFL 103
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 79/292 (27%), Positives = 131/292 (44%), Gaps = 25/292 (8%)
Query: 18 VAGGSAGLVEICLMHPLDVVKTRFQIQR---CATDPNS-YKSLVDSFRMIFQMEGLFGFY 73
VAG +GLV L+ P DV+K RFQ+Q +DP++ Y ++ + R I Q EG F+
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 74 KGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLT---EAIVVNPF 130
KG +P + AV+F +FE +L+ S+ A F++ + GL + V+P
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
Query: 131 EVVKVGLQANRNTFAEQPSTVGYARQII--KKEGWGLQGLNKGLTATLGRHGVFNMVYFG 188
+V++ A +P R + G Q KGL TL + + F
Sbjct: 140 DVLRTRFAAQ-----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 189 FYYNVKNM----IPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQ-----GPQ 239
Y ++K++ IP + E + G +G I+ + P D+ K R+Q +
Sbjct: 195 CYSSLKHLYKWAIPA-EGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHAR 253
Query: 240 PVPGEI-KYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEY 290
G++ +Y+ V Q+EG L +KGL P +++ M YE+
Sbjct: 254 AAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 65.9 bits (159), Expect = 4e-11
Identities = 55/199 (27%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 11 REASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLF 70
RE S V GG A + +HP+DV++TRF Q +P Y +L + +++ EG
Sbjct: 116 REFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQ 172
Query: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKLLGYV-----SLSPALTFAIAGLGSGLTEAI 125
FYKG+ P ++A P ++F + K L + + L + G G+G+
Sbjct: 173 VFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKT 232
Query: 126 VVNPFEVVKVGLQAN-----RNTFAEQPSTVGY---ARQIIKKEGWGLQGLNKGLTATLG 177
+ P ++ K LQ R F + G A+Q+++KE G G KGL+ +L
Sbjct: 233 LTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE--GALGFFKGLSPSLL 290
Query: 178 RHGV---FNMVYFGFYYNV 193
+ + F + F+ NV
Sbjct: 291 KAALSTGFMFFSYEFFCNV 309
Score = 58.2 bits (139), Expect = 9e-09
Identities = 51/202 (25%), Positives = 86/202 (42%), Gaps = 35/202 (17%)
Query: 113 AIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGY------ARQIIKKEG---- 162
A+AG SGL +++PF+V+K+ Q + + Y +RQI+++EG
Sbjct: 19 AVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAF 78
Query: 163 W------GLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLL 216
W + + G L + +V+ G Y+ + EF F G L
Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR-----------EFSVHFVCGGL 127
Query: 217 SGTIASVINIPFDVAKSRIQGPQPVPGEIK-YRTCFKTMATVYQEEGILALYKGLLPKIM 275
+ +A++ P DV ++R GE K Y T + T+Y+ EG YKGL P ++
Sbjct: 128 AACMATLTVHPVDVLRTRF----AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLI 183
Query: 276 RLGPGGAVMLLVY---EYTYSW 294
+ P + Y ++ Y W
Sbjct: 184 AIFPYAGLQFSCYSSLKHLYKW 205
Score = 53.5 bits (127), Expect = 2e-07
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 3 AKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQI------QRCATDPNSYKSL 56
A P E + ++ G AG++ L +PLD+ K R Q+ + YK L
Sbjct: 206 AIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGL 265
Query: 57 VDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFE 95
+D + + Q EG GF+KG+ P +L FF++E
Sbjct: 266 MDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 79/292 (27%), Positives = 131/292 (44%), Gaps = 25/292 (8%)
Query: 18 VAGGSAGLVEICLMHPLDVVKTRFQIQR---CATDPNS-YKSLVDSFRMIFQMEGLFGFY 73
VAG +GLV L+ P DV+K RFQ+Q +DP++ Y ++ + R I Q EG F+
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 74 KGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLT---EAIVVNPF 130
KG +P + AV+F +FE +L+ S+ A F++ + GL + V+P
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
Query: 131 EVVKVGLQANRNTFAEQPSTVGYARQII--KKEGWGLQGLNKGLTATLGRHGVFNMVYFG 188
+V++ A +P R + G Q KGL TL + + F
Sbjct: 140 DVLRTRFAAQ-----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 189 FYYNVKNM----IPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQ-----GPQ 239
Y ++K++ IP + E + G +G I+ + P D+ K R+Q +
Sbjct: 195 CYSSLKHLYKWAIPA-EGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHAR 253
Query: 240 PVPGEI-KYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEY 290
G++ +Y+ V Q+EG L +KGL P +++ M YE+
Sbjct: 254 AAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 65.9 bits (159), Expect = 4e-11
Identities = 55/199 (27%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 11 REASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLF 70
RE S V GG A + +HP+DV++TRF Q +P Y +L + +++ EG
Sbjct: 116 REFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQ 172
Query: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKLLGYV-----SLSPALTFAIAGLGSGLTEAI 125
FYKG+ P ++A P ++F + K L + + L + G G+G+
Sbjct: 173 VFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKT 232
Query: 126 VVNPFEVVKVGLQAN-----RNTFAEQPSTVGY---ARQIIKKEGWGLQGLNKGLTATLG 177
+ P ++ K LQ R F + G A+Q+++KE G G KGL+ +L
Sbjct: 233 LTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE--GALGFFKGLSPSLL 290
Query: 178 RHGV---FNMVYFGFYYNV 193
+ + F + F+ NV
Sbjct: 291 KAALSTGFMFFSYEFFCNV 309
Score = 58.2 bits (139), Expect = 9e-09
Identities = 51/202 (25%), Positives = 86/202 (42%), Gaps = 35/202 (17%)
Query: 113 AIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGY------ARQIIKKEG---- 162
A+AG SGL +++PF+V+K+ Q + + Y +RQI+++EG
Sbjct: 19 AVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAF 78
Query: 163 W------GLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLL 216
W + + G L + +V+ G Y+ + EF F G L
Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR-----------EFSVHFVCGGL 127
Query: 217 SGTIASVINIPFDVAKSRIQGPQPVPGEIK-YRTCFKTMATVYQEEGILALYKGLLPKIM 275
+ +A++ P DV ++R GE K Y T + T+Y+ EG YKGL P ++
Sbjct: 128 AACMATLTVHPVDVLRTRF----AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLI 183
Query: 276 RLGPGGAVMLLVY---EYTYSW 294
+ P + Y ++ Y W
Sbjct: 184 AIFPYAGLQFSCYSSLKHLYKW 205
Score = 53.5 bits (127), Expect = 2e-07
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 3 AKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQI------QRCATDPNSYKSL 56
A P E + ++ G AG++ L +PLD+ K R Q+ + YK L
Sbjct: 206 AIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGL 265
Query: 57 VDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFE 95
+D + + Q EG GF+KG+ P +L FF++E
Sbjct: 266 MDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 79/292 (27%), Positives = 131/292 (44%), Gaps = 25/292 (8%)
Query: 18 VAGGSAGLVEICLMHPLDVVKTRFQIQR---CATDPNS-YKSLVDSFRMIFQMEGLFGFY 73
VAG +GLV L+ P DV+K RFQ+Q +DP++ Y ++ + R I Q EG F+
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 74 KGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLT---EAIVVNPF 130
KG +P + AV+F +FE +L+ S+ A F++ + GL + V+P
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
Query: 131 EVVKVGLQANRNTFAEQPSTVGYARQII--KKEGWGLQGLNKGLTATLGRHGVFNMVYFG 188
+V++ A +P R + G Q KGL TL + + F
Sbjct: 140 DVLRTRFAAQ-----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 189 FYYNVKNM----IPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQ-----GPQ 239
Y ++K++ IP + E + G +G I+ + P D+ K R+Q +
Sbjct: 195 CYSSLKHLYKWAIPA-EGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHAR 253
Query: 240 PVPGEI-KYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEY 290
G++ +Y+ V Q+EG L +KGL P +++ M YE+
Sbjct: 254 AAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 65.9 bits (159), Expect = 4e-11
Identities = 55/199 (27%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 11 REASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLF 70
RE S V GG A + +HP+DV++TRF Q +P Y +L + +++ EG
Sbjct: 116 REFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQ 172
Query: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKLLGYV-----SLSPALTFAIAGLGSGLTEAI 125
FYKG+ P ++A P ++F + K L + + L + G G+G+
Sbjct: 173 VFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKT 232
Query: 126 VVNPFEVVKVGLQAN-----RNTFAEQPSTVGY---ARQIIKKEGWGLQGLNKGLTATLG 177
+ P ++ K LQ R F + G A+Q+++KE G G KGL+ +L
Sbjct: 233 LTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE--GALGFFKGLSPSLL 290
Query: 178 RHGV---FNMVYFGFYYNV 193
+ + F + F+ NV
Sbjct: 291 KAALSTGFMFFSYEFFCNV 309
Score = 58.2 bits (139), Expect = 9e-09
Identities = 51/202 (25%), Positives = 86/202 (42%), Gaps = 35/202 (17%)
Query: 113 AIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGY------ARQIIKKEG---- 162
A+AG SGL +++PF+V+K+ Q + + Y +RQI+++EG
Sbjct: 19 AVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAF 78
Query: 163 W------GLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLL 216
W + + G L + +V+ G Y+ + EF F G L
Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR-----------EFSVHFVCGGL 127
Query: 217 SGTIASVINIPFDVAKSRIQGPQPVPGEIK-YRTCFKTMATVYQEEGILALYKGLLPKIM 275
+ +A++ P DV ++R GE K Y T + T+Y+ EG YKGL P ++
Sbjct: 128 AACMATLTVHPVDVLRTRF----AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLI 183
Query: 276 RLGPGGAVMLLVY---EYTYSW 294
+ P + Y ++ Y W
Sbjct: 184 AIFPYAGLQFSCYSSLKHLYKW 205
Score = 53.5 bits (127), Expect = 2e-07
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 3 AKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQI------QRCATDPNSYKSL 56
A P E + ++ G AG++ L +PLD+ K R Q+ + YK L
Sbjct: 206 AIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGL 265
Query: 57 VDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFE 95
+D + + Q EG GF+KG+ P +L FF++E
Sbjct: 266 MDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
>gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens]
Length = 321
Score = 85.5 bits (210), Expect = 5e-17
Identities = 80/314 (25%), Positives = 139/314 (44%), Gaps = 43/314 (13%)
Query: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKS--------------------L 56
+ AGG G V PL+V+KTR Q R A Y L
Sbjct: 15 LFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVTPGL 74
Query: 57 VDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLG--YVSLSPALTFAI 114
+ I + EG ++G+ P ++ P RAV F + + K+ +V S +
Sbjct: 75 FQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVPNSNIVHIFS 134
Query: 115 AGLGSGLTEAIVVNPFEVVKVGLQANRNTF-AEQPSTVGYARQIIKKEGWGLQGLNKGLT 173
AG + +T +++ NP +VK +Q + ++Q +T+ AR + + EG ++G +GLT
Sbjct: 135 AGSAAFITNSLM-NPIWMVKTRMQLEQKVRGSKQMNTLQCARYVYQTEG--IRGFYRGLT 191
Query: 174 ATLGRHGVFN-MVYFGFYYNVKNMIPV---------NKDPILEFWRKFGIGLLSGTIASV 223
A+ G+ ++ F Y ++K + + F+ LS AS
Sbjct: 192 ASYA--GISETIICFAIYESLKKYLKEAPLASSANGTEKNSTSFFGLMAAAALSKGCASC 249
Query: 224 INIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAV 283
I P +V ++R++ KY++ +T V++EEG LA Y+GL +++R P A+
Sbjct: 250 IAYPHEVIRTRLREEGT-----KYKSFVQTARLVFREEGYLAFYRGLFAQLIRQIPNTAI 304
Query: 284 MLLVYEYTYSWLQE 297
+L YE L++
Sbjct: 305 VLSTYELIVYLLED 318
Score = 41.6 bits (96), Expect = 9e-04
Identities = 53/210 (25%), Positives = 75/210 (35%), Gaps = 27/210 (12%)
Query: 110 LTFAIAGLGSGLTEAIVVNPFEVVKVGLQANR----------------------NTFAEQ 147
L AG G AI P EV+K LQ++R +
Sbjct: 12 LLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVT 71
Query: 148 PSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEF 207
P + I++KE G + L +GL L VYF Y K P
Sbjct: 72 PGLFQVLKSILEKE--GPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVPNSNI 129
Query: 208 WRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALY 267
F G + S++N P + K+R+Q Q V G K + VYQ EGI Y
Sbjct: 130 VHIFSAGSAAFITNSLMN-PIWMVKTRMQLEQKVRGS-KQMNTLQCARYVYQTEGIRGFY 187
Query: 268 KGLLPKIMRLGPGGAVMLLVYEYTYSWLQE 297
+GL + + +YE +L+E
Sbjct: 188 RGLTASYAGISE-TIICFAIYESLKKYLKE 216
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 85.1 bits (209), Expect = 7e-17
Identities = 77/286 (26%), Positives = 127/286 (44%), Gaps = 18/286 (6%)
Query: 14 SRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNS-YKSLVDSFRMIFQMEGLFGF 72
S + AG AG++E +M+P+D VKTR +Q + DP + Y S+ + + I + EG +
Sbjct: 46 STHMTAGAMAGILEHSVMYPVDSVKTR--MQSLSPDPKAQYTSIYGALKKIMRTEGFWRP 103
Query: 73 YKGILPPILAETPKRAVKFFTFEQYKKLLGYV---SLSPALTFAIAGLGSGLTEAIVVNP 129
+G+ I+ P A+ F +E K+ L V + L IAG + L V+NP
Sbjct: 104 LRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNP 163
Query: 130 FEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGF 189
EVVK LQ ++ S + R + + EG G + T L + F ++F
Sbjct: 164 AEVVKQRLQMYN---SQHRSAISCIRTVWRTEGLG--AFYRSYTTQLTMNIPFQSIHFIT 218
Query: 190 YYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEI---- 245
Y ++ VN G L+G +A+ P DV K+ + + V +
Sbjct: 219 YEFLQEQ--VNPHRTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANIS 276
Query: 246 -KYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEY 290
+ TVYQ G+ +KG+ +++ P A+ VYE+
Sbjct: 277 GRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEF 322
Score = 52.0 bits (123), Expect = 6e-07
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQR-----CATDPNSYKSLVDSFRMIFQMEGLFG 71
I++GG AG + PLDV KT Q A + ++FR ++Q+ GL G
Sbjct: 238 IISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAG 297
Query: 72 FYKGILPPILAETPKRAVKFFTFEQYKKLL 101
++KGI ++ + P A+ + +E +K L
Sbjct: 298 YFKGIQARVIYQMPSTAISWSVYEFFKYFL 327
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 85.1 bits (209), Expect = 7e-17
Identities = 73/288 (25%), Positives = 132/288 (45%), Gaps = 16/288 (5%)
Query: 14 SRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCA---TDPNSYKSLVDSFRMIFQMEGLF 70
++ +AGG A + + P++ VK Q+Q + T YK ++D I + +G+
Sbjct: 9 AKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVL 68
Query: 71 GFYKGILPPILAETPKRAVKFFTFEQYKKL-LGYVSLSPA--LTFA---IAGLGSGLTEA 124
F++G L ++ P +A+ F ++YK++ LG V L FA +G +G T
Sbjct: 69 SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSL 128
Query: 125 IVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIK-KEGWGLQGLNKGLTATLGRHGVFN 183
V P + + L A+ + G ++K + G++GL +G ++ ++
Sbjct: 129 CFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYR 188
Query: 184 MVYFGFYYNVKNMIPVNKDP-ILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVP 242
YFG Y K M+P K+ I+ W I +A + + PFD + R+
Sbjct: 189 AAYFGIYDTAKGMLPDPKNTHIVISWM---IAQTVTAVAGLTSYPFDTVRRRMMMQSGRK 245
Query: 243 G-EIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
G +I Y + ++EG A +KG ++R G GGA +L++Y+
Sbjct: 246 GTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR-GMGGAFVLVLYD 292
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,977,674
Number of Sequences: 37866
Number of extensions: 456607
Number of successful extensions: 1467
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 876
Number of HSP's gapped (non-prelim): 215
length of query: 299
length of database: 18,247,518
effective HSP length: 102
effective length of query: 197
effective length of database: 14,385,186
effective search space: 2833881642
effective search space used: 2833881642
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.