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Search of human proteins with 52426761
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon
precursor [Homo sapiens]
(506 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon p... 1041 0.0
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 409 e-114
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 409 e-114
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 407 e-113
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 402 e-112
gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform... 388 e-108
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs... 318 9e-87
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor... 304 1e-82
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr... 304 1e-82
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso... 304 1e-82
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 298 1e-80
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 298 1e-80
gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 298 1e-80
gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 298 1e-80
gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 298 1e-80
gi|189083724 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 298 1e-80
gi|38327554 gamma-aminobutyric acid (GABA) A receptor, alpha 1 p... 298 1e-80
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 293 3e-79
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 293 3e-79
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 253 2e-67
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 253 2e-67
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 251 1e-66
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 251 1e-66
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 244 1e-64
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 239 3e-63
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo... 236 4e-62
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] 236 4e-62
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 236 5e-62
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 236 5e-62
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 235 8e-62
>gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon
precursor [Homo sapiens]
Length = 506
Score = 1041 bits (2691), Expect = 0.0
Identities = 506/506 (100%), Positives = 506/506 (100%)
Query: 1 MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE 60
MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE
Sbjct: 1 MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE 60
Query: 61 TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI 120
TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI
Sbjct: 61 TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI 120
Query: 121 IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD 180
IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD
Sbjct: 121 IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD 180
Query: 181 GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW 240
GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW
Sbjct: 181 GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW 240
Query: 241 KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW 300
KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW
Sbjct: 241 KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW 300
Query: 301 IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV 360
IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV
Sbjct: 301 IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV 360
Query: 361 LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER 420
LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER
Sbjct: 361 LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER 420
Query: 421 PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL 480
PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL
Sbjct: 421 PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL 480
Query: 481 DNYSRVVFPVTFFFFNVLYWLVCLNL 506
DNYSRVVFPVTFFFFNVLYWLVCLNL
Sbjct: 481 DNYSRVVFPVTFFFFNVLYWLVCLNL 506
>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
[Homo sapiens]
Length = 467
Score = 409 bits (1051), Expect = e-114
Identities = 202/441 (45%), Positives = 276/441 (62%), Gaps = 23/441 (5%)
Query: 70 EASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDE 129
+ + ILN +L YD KLRP IG KPTV+ V+I VNS+GP+S ++MEY IDI F+QTW D
Sbjct: 46 DVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDS 105
Query: 130 RLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRM 189
RL +N T + L LN N+V +WIPDT FRNSK H IT PNQ++RI+ DGK+LYT+R+
Sbjct: 106 RLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRL 165
Query: 190 TIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTG 249
TI+A C L + FPMD HSCPL FSS+ YP+ EMIY+W +E ++ SW+L+QFDF G
Sbjct: 166 TINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMG 225
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ N TEI+TT GD++VMTI+F +SRR GY Q Y+P +T +LSWVSFWIK ++ PAR
Sbjct: 226 LRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPAR 285
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFL--IYN 367
T+LGIT+VLTMTTL T +RK+ PRVSY+TA+D ++ +CF+F F AL+E+A LN+
Sbjct: 286 TALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRK 345
Query: 368 QTKAHASPKLRHPRINSRAHAR--TRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSA 425
T + L HP + R +A S + I +E
Sbjct: 346 PTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCV 405
Query: 426 QQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSR 485
+ C K + +FC +C+ +W++GR+ I + LD+YSR
Sbjct: 406 YE-------------------CLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSR 446
Query: 486 VVFPVTFFFFNVLYWLVCLNL 506
V FP +F FN++YW+ L L
Sbjct: 447 VFFPTSFLLFNLVYWVGYLYL 467
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 409 bits (1050), Expect = e-114
Identities = 193/445 (43%), Positives = 285/445 (64%), Gaps = 42/445 (9%)
Query: 67 KLPEA--SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQ 124
K+PE + ILN +L YD+KLRP IG KPT++ ++ VNS+GP++ ++MEYTIDI F+Q
Sbjct: 60 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ 119
Query: 125 TWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVL 184
TWYD RL +N T + L LN N+V ++WIPDTFFRNSK+ H IT PN+M+RI+ DG+VL
Sbjct: 120 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 179
Query: 185 YTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQ 244
YT+R+TIDA C L + FPMD HSCPL FSS+ YP E++Y+W+ +E+ + SW+L+Q
Sbjct: 180 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQ 239
Query: 245 FDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTE 304
F F G+ N TE++ T GD++VM+++F++SRR GY Q Y+P ++ +LSWVSFWI +
Sbjct: 240 FSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKD 299
Query: 305 SAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFL 364
+ PARTSLGIT+VLTMTTL T +RK+ P+VSY+TA+D ++++CF+F F AL+E+ L++
Sbjct: 300 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYF 359
Query: 365 IYNQTKAHASPKLRH---PRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERP 421
+ N+ + K + P I+ R + T + A Q ++ + E DG++
Sbjct: 360 VSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERD----EEYGYECLDGKDCA 415
Query: 422 SCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLD 481
S +FC DC W+ GR+ I + ++D
Sbjct: 416 S---------------------------------FFCCFEDCRTGAWRHGRIHIRIAKMD 442
Query: 482 NYSRVVFPVTFFFFNVLYWLVCLNL 506
+Y+R+ FP F FN++YW+ L L
Sbjct: 443 SYARIFFPTAFCLFNLVYWVSYLYL 467
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 407 bits (1046), Expect = e-113
Identities = 196/453 (43%), Positives = 287/453 (63%), Gaps = 50/453 (11%)
Query: 67 KLPEA--SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQ 124
K+PE + ILN +L YD+KLRP IG KPT++ ++ VNS+GP++ ++MEYTIDI F+Q
Sbjct: 60 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ 119
Query: 125 TWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVL 184
TWYD RL +N T + L LN N+V ++WIPDTFFRNSK+ H IT PN+M+RI+ DG+VL
Sbjct: 120 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 179
Query: 185 YTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQ 244
YT+R+TIDA C L + FPMD HSCPL FSS+ YP E++Y+W+ +E+ + SW+L+Q
Sbjct: 180 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQ 239
Query: 245 FDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTE 304
F F G+ N TE++ T GD++VM+++F++SRR GY Q Y+P ++ +LSWVSFWI +
Sbjct: 240 FSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKD 299
Query: 305 SAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFL 364
+ PARTSLGIT+VLTMTTL T +RK+ P+VSY+TA+D ++++CF+F F AL+E+ L++
Sbjct: 300 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYF 359
Query: 365 IYN------QTKAHASPKLR-----HPRINSRAHARTRARSRACARQHQEAFVCQIVTTE 413
+ N + K +P LR P I+ R + T + A Q ++ + E
Sbjct: 360 VSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERD----EEYGYE 415
Query: 414 GSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRL 473
DG++ S +FC DC W+ GR+
Sbjct: 416 CLDGKDCAS---------------------------------FFCCFEDCRTGAWRHGRI 442
Query: 474 CIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLNL 506
I + ++D+Y+R+ FP F FN++YW+ L L
Sbjct: 443 HIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 402 bits (1032), Expect = e-112
Identities = 195/437 (44%), Positives = 283/437 (64%), Gaps = 34/437 (7%)
Query: 70 EASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDE 129
+ ++ILN++L YD+KLRP IG +PTV+ ++ VNS+GP+ ++MEYTIDIIF+QTW+D
Sbjct: 63 DITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDS 122
Query: 130 RLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRM 189
RL +N T + L+LN N+V ++WIPDTFFRNS+++ H IT PN+++RI+ DG+VLYT+R+
Sbjct: 123 RLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRL 182
Query: 190 TIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTG 249
TI+A C L + FPMD HSCPL FSS+ YP+NE+ YKW+ +E+ + W+L+QF F G
Sbjct: 183 TINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVG 242
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ N TEI T GD+++MTIFF++SRR GY Q Y+P +T +LSWVSFWI ++ PAR
Sbjct: 243 LRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPAR 302
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQT 369
TSLGIT+VLTMTTL T +RK+ P+VSY+TA+D ++++CF+F F AL+E+ L++ NQ
Sbjct: 303 TSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQ- 361
Query: 370 KAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPP 429
K + K R ++ ++A GS + S Q
Sbjct: 362 KGKTATKDR--KLKNKASMTPGLH-------------------PGSTLIPMNNISVPQED 400
Query: 430 SPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFP 489
G C E K +FC DC +W++GR+ I + ++D+YSR+ FP
Sbjct: 401 DYG-----------YQCLEG-KDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFP 448
Query: 490 VTFFFFNVLYWLVCLNL 506
F FN++YW+ L L
Sbjct: 449 TAFALFNLVYWVGYLYL 465
>gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3
precursor [Homo sapiens]
Length = 515
Score = 388 bits (997), Expect = e-108
Identities = 197/493 (39%), Positives = 288/493 (58%), Gaps = 90/493 (18%)
Query: 67 KLPEA--SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQ 124
K+PE + ILN +L YD+KLRP IG KPT++ ++ VNS+GP++ ++MEYTIDI F+Q
Sbjct: 60 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ 119
Query: 125 TWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVL 184
TWYD RL +N T + L LN N+V ++WIPDTFFRNSK+ H IT PN+M+RI+ DG+VL
Sbjct: 120 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 179
Query: 185 YTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFS--------------------------- 217
YT+R+TIDA C L + FPMD HSCPL FSS+S
Sbjct: 180 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDP 239
Query: 218 -------------YPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKTEIITTPVGDF 264
YP E++Y+W+ +E+ + SW+L+QF F G+ N TE++ T GD+
Sbjct: 240 PTLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDY 299
Query: 265 MVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLG 324
+VM+++F++SRR GY Q Y+P ++ +LSWVSFWI ++ PARTSLGIT+VLTMTTL
Sbjct: 300 VVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLS 359
Query: 325 TFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYN------QTKAHASPKLR 378
T +RK+ P+VSY+TA+D ++++CF+F F AL+E+ L++ + N + K +P LR
Sbjct: 360 TIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLR 419
Query: 379 -----HPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPGS 433
P I+ R + T + A Q ++ + E DG++ S
Sbjct: 420 MFSFKAPTIDIRPRSATIQMNNATHLQERD----EEYGYECLDGKDCAS----------- 464
Query: 434 PEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFF 493
+FC DC W+ GR+ I + ++D+Y+R+ FP F
Sbjct: 465 ----------------------FFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFC 502
Query: 494 FFNVLYWLVCLNL 506
FN++YW+ L L
Sbjct: 503 LFNLVYWVSYLYL 515
>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
[Homo sapiens]
Length = 453
Score = 318 bits (814), Expect = 9e-87
Identities = 170/440 (38%), Positives = 255/440 (57%), Gaps = 36/440 (8%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
SRIL+ +L YD++LRPG G T V +I V S GP+S ++MEYT+D+ F QTW DERL
Sbjct: 33 SRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERL 92
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ E L LN +VS++W PDTFFRN K++ H +T PN++ RI ++G +LYT+R+TI
Sbjct: 93 KFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTI 152
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWEN---FKLEINEKNSWKLFQFDFT 248
+A C + ++ FPMD H+CPL F S++YP++E+IY W+ + +E+ E++S L Q+D
Sbjct: 153 NADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESS-SLLQYDLI 211
Query: 249 GVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPA 308
G + +E I + G++++MT++F++ R+ GY Q Y P +T +LS VSFWI ES PA
Sbjct: 212 GQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPA 271
Query: 309 RTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQ 368
RT GIT+VLTMTTL +R + P+VSY TA+D++IA+CF F F AL+EFA +N+ Q
Sbjct: 272 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQ 331
Query: 369 TKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQP 428
T+ ++ A+ A + E +IV S + ++
Sbjct: 332 TQ------------KAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSL 379
Query: 429 PSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCI---HVYRLDNYSR 485
P S E K P + + L ++D YSR
Sbjct: 380 PIVSSSEA-----------------NKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSR 422
Query: 486 VVFPVTFFFFNVLYWLVCLN 505
++FPV F FN++YW+V L+
Sbjct: 423 ILFPVAFAGFNLVYWVVYLS 442
>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
[Homo sapiens]
Length = 492
Score = 304 bits (779), Expect = 1e-82
Identities = 163/437 (37%), Positives = 252/437 (57%), Gaps = 27/437 (6%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+G+ T V +I V S GP+S DMEYTID+ F QTW+DERL
Sbjct: 68 TRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERL 127
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
++ + L LN + S++W PDTFF N K++ H +T PN+++R+ +G +LYT+R+TI
Sbjct: 128 KFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTI 187
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW---ENFKLEINEKNSWKLFQFDFT 248
A C +H+ FPMD H+CPL F S++Y E++Y W +N +E+ + S +L Q+D
Sbjct: 188 HAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGS-RLNQYDLL 246
Query: 249 GVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPA 308
G TEII + G+++VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PA
Sbjct: 247 GHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 306
Query: 309 RTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQ 368
RT G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+ +
Sbjct: 307 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT-KR 365
Query: 369 TKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQP 428
+ A K+ A + A A++ F T + ++ + +
Sbjct: 366 SWAWEGKKV------PEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKG 419
Query: 429 PSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVF 488
+P + P + S K + E T+ V ++D SR++F
Sbjct: 420 AAPSASSTPTIIASP----------KATYVQDSPTETKTYNS------VSKVDKISRIIF 463
Query: 489 PVTFFFFNVLYWLVCLN 505
PV F FN++YW +N
Sbjct: 464 PVLFAIFNLVYWATYVN 480
>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
precursor [Homo sapiens]
Length = 462
Score = 304 bits (779), Expect = 1e-82
Identities = 167/462 (36%), Positives = 255/462 (55%), Gaps = 56/462 (12%)
Query: 54 TKSTETETGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILD 113
T S + ET + +RIL+ +L YD++LRPG+GE+ T V +I V S GP+S +
Sbjct: 35 TSSVKDETNDNITIF---TRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTE 91
Query: 114 MEYTIDIIFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQ 173
MEYTID+ F Q+W DERL + + L LN + S++W PDTFF N K++ H +T PN+
Sbjct: 92 MEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNK 151
Query: 174 MVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWEN--FK 231
++R+ DG +LYT+R+TI A C + + FPMD+H+CPL F S++YP +E++Y W N K
Sbjct: 152 LLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTK 211
Query: 232 LEINEKNSWKLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVT 291
+ ++ +L Q+ G + TE I+T G++ +MT F++ R+ GY Q Y+P +T
Sbjct: 212 SVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMT 271
Query: 292 TMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFC 351
+LS VSFW+ ES PART G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F
Sbjct: 272 VILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFV 331
Query: 352 FCALLEFAVLNFL-----IYNQTKAHASPKLRHPR---INSRAHARTRARSRACARQHQE 403
F AL+EFA +N+ ++ KA + K++ R +N +A T +
Sbjct: 332 FSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKM--------- 382
Query: 404 AFVCQIVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDC 463
P+ +Q P+ S S V
Sbjct: 383 --------------SHPPNIPKEQTPAGTSNTTSVS--------------------VKPS 408
Query: 464 EGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLN 505
E T + + + ++D SR+VFPV F FN++YW LN
Sbjct: 409 EEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLN 450
>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
[Homo sapiens]
Length = 554
Score = 304 bits (778), Expect = 1e-82
Identities = 161/380 (42%), Positives = 234/380 (61%), Gaps = 20/380 (5%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+++L YD++LRPG G T V +I V S GP+S ++MEYT+D+ F QTW D+RL
Sbjct: 49 TRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRL 108
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
Y+ E L LN +V+++W PDTFFRN K++ H +T PN++ RI ++G +LYT+R+TI
Sbjct: 109 KYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTI 168
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINE--KNSWKLFQFDFTG 249
A C + ++ FPMD H+CPL F S++YP++EMIY W + E K S L Q+D G
Sbjct: 169 SAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIG 228
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ +E I + G+++VMT++F++ R+ GY Q Y+P +T +LS VSFWI ES PAR
Sbjct: 229 QTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPAR 288
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQ- 368
T GIT+VLTMTTL +R + P+VSY TA+D++IA+CF F F AL+EFA +N+ Q
Sbjct: 289 TVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQM 348
Query: 369 -----------TKAHASP--KLRHPRIN-SRAHARTRARSRACARQHQEAFVCQIVTTEG 414
+ A+P + +HP +A R R A H E+ V TE
Sbjct: 349 EKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGN--RTEV 406
Query: 415 SDGEERPSCSAQQPPSPGSP 434
+ + S Q+ S G+P
Sbjct: 407 GNHSSKSSTVVQE-SSKGTP 425
Score = 39.3 bits (90), Expect = 0.009
Identities = 14/27 (51%), Positives = 23/27 (85%)
Query: 479 RLDNYSRVVFPVTFFFFNVLYWLVCLN 505
++D Y+R++FPVTF FN++YW+V L+
Sbjct: 517 KIDKYARILFPVTFGAFNMVYWVVYLS 543
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 298 bits (762), Expect = 1e-80
Identities = 164/446 (36%), Positives = 246/446 (55%), Gaps = 56/446 (12%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+GE+ T V +I V S GP+S DMEYTID+ F Q+W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI +DG +LYT+R+T+
Sbjct: 103 KFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW--ENFKLEINEKNSWKLFQFDFTG 249
A C +H+ FPMD+H+CPL F S++Y E++Y+W E + + ++ +L Q+D G
Sbjct: 163 RAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLG 222
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ + I+ + G+++VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PAR
Sbjct: 223 QTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIY--- 366
T G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGY 342
Query: 367 ----NQTKAHASPKLRHPRI---NSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE 419
K++ P I N+ A T A + + T E E
Sbjct: 343 AWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPK--EV 400
Query: 420 RPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYR 479
+P +PP P KK F V +
Sbjct: 401 KPE---TKPPEP----------------------KKTFNSVS-----------------K 418
Query: 480 LDNYSRVVFPVTFFFFNVLYWLVCLN 505
+D SR+ FP+ F FN++YW LN
Sbjct: 419 IDRLSRIAFPLLFGIFNLVYWATYLN 444
>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 298 bits (762), Expect = 1e-80
Identities = 164/446 (36%), Positives = 246/446 (55%), Gaps = 56/446 (12%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+GE+ T V +I V S GP+S DMEYTID+ F Q+W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI +DG +LYT+R+T+
Sbjct: 103 KFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW--ENFKLEINEKNSWKLFQFDFTG 249
A C +H+ FPMD+H+CPL F S++Y E++Y+W E + + ++ +L Q+D G
Sbjct: 163 RAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLG 222
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ + I+ + G+++VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PAR
Sbjct: 223 QTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIY--- 366
T G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGY 342
Query: 367 ----NQTKAHASPKLRHPRI---NSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE 419
K++ P I N+ A T A + + T E E
Sbjct: 343 AWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPK--EV 400
Query: 420 RPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYR 479
+P +PP P KK F V +
Sbjct: 401 KPE---TKPPEP----------------------KKTFNSVS-----------------K 418
Query: 480 LDNYSRVVFPVTFFFFNVLYWLVCLN 505
+D SR+ FP+ F FN++YW LN
Sbjct: 419 IDRLSRIAFPLLFGIFNLVYWATYLN 444
>gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 298 bits (762), Expect = 1e-80
Identities = 164/446 (36%), Positives = 246/446 (55%), Gaps = 56/446 (12%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+GE+ T V +I V S GP+S DMEYTID+ F Q+W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI +DG +LYT+R+T+
Sbjct: 103 KFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW--ENFKLEINEKNSWKLFQFDFTG 249
A C +H+ FPMD+H+CPL F S++Y E++Y+W E + + ++ +L Q+D G
Sbjct: 163 RAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLG 222
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ + I+ + G+++VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PAR
Sbjct: 223 QTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIY--- 366
T G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGY 342
Query: 367 ----NQTKAHASPKLRHPRI---NSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE 419
K++ P I N+ A T A + + T E E
Sbjct: 343 AWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPK--EV 400
Query: 420 RPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYR 479
+P +PP P KK F V +
Sbjct: 401 KPE---TKPPEP----------------------KKTFNSVS-----------------K 418
Query: 480 LDNYSRVVFPVTFFFFNVLYWLVCLN 505
+D SR+ FP+ F FN++YW LN
Sbjct: 419 IDRLSRIAFPLLFGIFNLVYWATYLN 444
>gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 298 bits (762), Expect = 1e-80
Identities = 164/446 (36%), Positives = 246/446 (55%), Gaps = 56/446 (12%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+GE+ T V +I V S GP+S DMEYTID+ F Q+W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI +DG +LYT+R+T+
Sbjct: 103 KFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW--ENFKLEINEKNSWKLFQFDFTG 249
A C +H+ FPMD+H+CPL F S++Y E++Y+W E + + ++ +L Q+D G
Sbjct: 163 RAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLG 222
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ + I+ + G+++VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PAR
Sbjct: 223 QTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIY--- 366
T G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGY 342
Query: 367 ----NQTKAHASPKLRHPRI---NSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE 419
K++ P I N+ A T A + + T E E
Sbjct: 343 AWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPK--EV 400
Query: 420 RPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYR 479
+P +PP P KK F V +
Sbjct: 401 KPE---TKPPEP----------------------KKTFNSVS-----------------K 418
Query: 480 LDNYSRVVFPVTFFFFNVLYWLVCLN 505
+D SR+ FP+ F FN++YW LN
Sbjct: 419 IDRLSRIAFPLLFGIFNLVYWATYLN 444
>gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 298 bits (762), Expect = 1e-80
Identities = 164/446 (36%), Positives = 246/446 (55%), Gaps = 56/446 (12%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+GE+ T V +I V S GP+S DMEYTID+ F Q+W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI +DG +LYT+R+T+
Sbjct: 103 KFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW--ENFKLEINEKNSWKLFQFDFTG 249
A C +H+ FPMD+H+CPL F S++Y E++Y+W E + + ++ +L Q+D G
Sbjct: 163 RAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLG 222
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ + I+ + G+++VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PAR
Sbjct: 223 QTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIY--- 366
T G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGY 342
Query: 367 ----NQTKAHASPKLRHPRI---NSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE 419
K++ P I N+ A T A + + T E E
Sbjct: 343 AWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPK--EV 400
Query: 420 RPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYR 479
+P +PP P KK F V +
Sbjct: 401 KPE---TKPPEP----------------------KKTFNSVS-----------------K 418
Query: 480 LDNYSRVVFPVTFFFFNVLYWLVCLN 505
+D SR+ FP+ F FN++YW LN
Sbjct: 419 IDRLSRIAFPLLFGIFNLVYWATYLN 444
>gi|189083724 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 298 bits (762), Expect = 1e-80
Identities = 164/446 (36%), Positives = 246/446 (55%), Gaps = 56/446 (12%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+GE+ T V +I V S GP+S DMEYTID+ F Q+W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI +DG +LYT+R+T+
Sbjct: 103 KFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW--ENFKLEINEKNSWKLFQFDFTG 249
A C +H+ FPMD+H+CPL F S++Y E++Y+W E + + ++ +L Q+D G
Sbjct: 163 RAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLG 222
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ + I+ + G+++VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PAR
Sbjct: 223 QTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIY--- 366
T G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGY 342
Query: 367 ----NQTKAHASPKLRHPRI---NSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE 419
K++ P I N+ A T A + + T E E
Sbjct: 343 AWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPK--EV 400
Query: 420 RPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYR 479
+P +PP P KK F V +
Sbjct: 401 KPE---TKPPEP----------------------KKTFNSVS-----------------K 418
Query: 480 LDNYSRVVFPVTFFFFNVLYWLVCLN 505
+D SR+ FP+ F FN++YW LN
Sbjct: 419 IDRLSRIAFPLLFGIFNLVYWATYLN 444
>gi|38327554 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 298 bits (762), Expect = 1e-80
Identities = 164/446 (36%), Positives = 246/446 (55%), Gaps = 56/446 (12%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+GE+ T V +I V S GP+S DMEYTID+ F Q+W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI +DG +LYT+R+T+
Sbjct: 103 KFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW--ENFKLEINEKNSWKLFQFDFTG 249
A C +H+ FPMD+H+CPL F S++Y E++Y+W E + + ++ +L Q+D G
Sbjct: 163 RAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLG 222
Query: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
+ + I+ + G+++VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PAR
Sbjct: 223 QTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282
Query: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIY--- 366
T G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGY 342
Query: 367 ----NQTKAHASPKLRHPRI---NSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE 419
K++ P I N+ A T A + + T E E
Sbjct: 343 AWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPK--EV 400
Query: 420 RPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYR 479
+P +PP P KK F V +
Sbjct: 401 KPE---TKPPEP----------------------KKTFNSVS-----------------K 418
Query: 480 LDNYSRVVFPVTFFFFNVLYWLVCLN 505
+D SR+ FP+ F FN++YW LN
Sbjct: 419 IDRLSRIAFPLLFGIFNLVYWATYLN 444
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 293 bits (750), Expect = 3e-79
Identities = 165/441 (37%), Positives = 242/441 (54%), Gaps = 48/441 (10%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+G+ T V I V S GP+S DMEYTID+ F Q W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI DG +LYT+R+T+
Sbjct: 103 KFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW---ENFKLEINEKNSWKLFQFDFT 248
A C +H+ FPMD+HSCPL F S++Y +E+ Y W + +++ S +L Q+D
Sbjct: 163 QAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGS-RLNQYDLL 221
Query: 249 GVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPA 308
G S E I + G++ VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PA
Sbjct: 222 GQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 281
Query: 309 RTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQ 368
RT G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 282 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF---- 337
Query: 369 TKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE----RPSCS 424
TK R + ++ + + +A A+ + + ++ S S
Sbjct: 338 TK-------RGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKS 390
Query: 425 AQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYS 484
A P PE + E K F V ++D S
Sbjct: 391 ATTPEPNKKPENKPA--------EAKKTFNS---------------------VSKIDRMS 421
Query: 485 RVVFPVTFFFFNVLYWLVCLN 505
R+VFPV F FN++YW LN
Sbjct: 422 RIVFPVLFGTFNLVYWATYLN 442
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 293 bits (750), Expect = 3e-79
Identities = 165/441 (37%), Positives = 242/441 (54%), Gaps = 48/441 (10%)
Query: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
+RIL+ +L YD++LRPG+G+ T V I V S GP+S DMEYTID+ F Q W DERL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102
Query: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
+ L LN + S++W PDTFF N K++ H +TMPN+++RI DG +LYT+R+T+
Sbjct: 103 KFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTV 162
Query: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW---ENFKLEINEKNSWKLFQFDFT 248
A C +H+ FPMD+HSCPL F S++Y +E+ Y W + +++ S +L Q+D
Sbjct: 163 QAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGS-RLNQYDLL 221
Query: 249 GVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPA 308
G S E I + G++ VMT F++ R+ GY Q Y+P +T +LS VSFW+ ES PA
Sbjct: 222 GQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 281
Query: 309 RTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQ 368
RT G+T+VLTMTTL +R + P+V+Y TA+D++IA+C+ F F AL+EFA +N+
Sbjct: 282 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF---- 337
Query: 369 TKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEE----RPSCS 424
TK R + ++ + + +A A+ + + ++ S S
Sbjct: 338 TK-------RGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKS 390
Query: 425 AQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYS 484
A P PE + E K F V ++D S
Sbjct: 391 ATTPEPNKKPENKPA--------EAKKTFNS---------------------VSKIDRMS 421
Query: 485 RVVFPVTFFFFNVLYWLVCLN 505
R+VFPV F FN++YW LN
Sbjct: 422 RIVFPVLFGTFNLVYWATYLN 442
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 253 bits (647), Expect = 2e-67
Identities = 148/475 (31%), Positives = 237/475 (49%), Gaps = 44/475 (9%)
Query: 54 TKSTETETGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILD 113
T+ +E + + G + ++ +L YD +LRP G P V + I + S+ +S ++
Sbjct: 20 TRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVN 79
Query: 114 MEYTIDIIFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQ 173
M+YT+ + F Q W D+RL Y+ +L L+ V QLW+PDT+F N K++ H +T+ N+
Sbjct: 80 MDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNR 139
Query: 174 MVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLE 233
M+R++ DG VLY +R+T A C + + R+P+D +C L S+ Y +++ + W
Sbjct: 140 MIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKA 199
Query: 234 INEKNSWKLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTM 293
+ +L QF + + G + +++ F + R GY Q Y+PS + T+
Sbjct: 200 VTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITI 259
Query: 294 LSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFC 353
LSWVSFWI +++ AR +LGIT+VLTMTT+ T R+ P++ Y+ A+D Y+ CFVF F
Sbjct: 260 LSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFL 319
Query: 354 ALLEFAVLNFLIY------NQTKAHASPKLRHPRINSR-----AHARTRARSRACARQHQ 402
ALLE+A +N++ + + A + K ++ R S AH S +
Sbjct: 320 ALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMN 379
Query: 403 EAFVCQIVTTEGSDGEERPSCSA----------QQPPSPGSPE--GPRSLCSKLACCEWC 450
E G G+ R S + Q P G G RSL K
Sbjct: 380 E--------VSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLR-- 429
Query: 451 KRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLN 505
+R + +PD V +D +SR+VFP TF FN++YWL +N
Sbjct: 430 RRSSQLKIKIPD-----------LTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 253 bits (647), Expect = 2e-67
Identities = 144/444 (32%), Positives = 231/444 (52%), Gaps = 31/444 (6%)
Query: 75 LNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLCYN 134
++ +L YD +LRP G P V + I V S+ +S ++M+YT+ + F Q+W D+RL Y+
Sbjct: 41 VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
Query: 135 DTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTIDAG 194
+L L+ V QLW+PDT+F N K++ H +T+ N+M+R++ DG VLY +R+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 195 CSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQF---DFTGVS 251
C + + R+P+D +C L S+ Y +++ + W + + N +L QF D+ VS
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVS 220
Query: 252 NKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTS 311
K E T G + +++ F + R GY Q Y+PS++ T+LSWVSFWI +++ AR +
Sbjct: 221 KKVEFTT---GAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVA 277
Query: 312 LGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQ--- 368
LGIT+VLTMTT+ T R+ P++ Y+ A+D Y+ CFVF F ALLE+A +N++ + +
Sbjct: 278 LGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ 337
Query: 369 --------TKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER 420
A+ KL ++ AH + + + V V+ +
Sbjct: 338 KKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSY 397
Query: 421 PSCSAQQPPSPGSPEGPRSLCSKLAC---CEWCKRFKKYFCMVPDCEGSTWQQGRLCIHV 477
S S Q S E + +R + +PD V
Sbjct: 398 DSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPD-----------LTDV 446
Query: 478 YRLDNYSRVVFPVTFFFFNVLYWL 501
+D +SR+ FP+TF FNV+YWL
Sbjct: 447 NSIDKWSRMFFPITFSLFNVVYWL 470
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 251 bits (641), Expect = 1e-66
Identities = 143/452 (31%), Positives = 235/452 (51%), Gaps = 38/452 (8%)
Query: 75 LNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLCYN 134
++ +L YD +LRP G P V + I + S+ +S ++M+YT+ + F Q W D+RL YN
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 135 DTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTIDAG 194
+L L+ V QLW+PDT+F N K++ H +T+ N+M+R++ DG VLY +R+T A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
Query: 195 CSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKT 254
C + + R+P+D +C L S+ Y +++ + W + +L QF T
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219
Query: 255 EIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGI 314
+ + G + +++ F + R GY Q Y+PS + T+LSWVSFWI +++ AR +LGI
Sbjct: 220 KKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 279
Query: 315 TSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAHAS 374
T+VLTMTT+ T R+ P++ Y+ A+D Y+ CFVF F ALLE+A++N++ + +
Sbjct: 280 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGR-----G 334
Query: 375 PKLRHPRINSRAHARTRARSRACARQ---HQEAFVC------QIVTTEGSDGEERP---- 421
P+ R + +A + + R + H+ + ++ T+E G P
Sbjct: 335 PQ-RQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTM 393
Query: 422 ---SCSAQQPPSPGSPE---GPRSLCSKLA--CCEWCKRFKKYFCMVPDCEGSTWQQGRL 473
S+ Q G P G +L +A +R + +PD
Sbjct: 394 LAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD----------- 442
Query: 474 CIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLN 505
V +D +SR+ FPV F FFN++YWL +N
Sbjct: 443 LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 251 bits (640), Expect = 1e-66
Identities = 146/463 (31%), Positives = 231/463 (49%), Gaps = 44/463 (9%)
Query: 66 GKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQT 125
G + ++ +L YD +LRP G P V + I + S+ +S ++M+YT+ + F Q
Sbjct: 32 GNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQY 91
Query: 126 WYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLY 185
W D+RL Y+ +L L+ V QLW+PDT+F N K++ H +T+ N+M+R++ DG VLY
Sbjct: 92 WRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 151
Query: 186 TIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQF 245
+R+T A C + + R+P+D +C L S+ Y +++ + W + +L QF
Sbjct: 152 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQF 211
Query: 246 DFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTES 305
+ + G + +++ F + R GY Q Y+PS + T+LSWVSFWI ++
Sbjct: 212 SIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDA 271
Query: 306 APARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLI 365
+ AR +LGIT+VLTMTT+ T R+ P++ Y+ A+D Y+ CFVF F ALLE+A +N++
Sbjct: 272 SAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIF 331
Query: 366 Y------NQTKAHASPKLRHPRINSR-----AHARTRARSRACARQHQEAFVCQIVTTEG 414
+ + A + K ++ R S AH S + E G
Sbjct: 332 FGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNE--------VSG 383
Query: 415 SDGEERPSCSA----------QQPPSPGSPE--GPRSLCSKLACCEWCKRFKKYFCMVPD 462
G+ R S + Q P G G RSL K +R + +PD
Sbjct: 384 GIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLR--RRSSQLKIKIPD 441
Query: 463 CEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLN 505
V +D +SR+VFP TF FN++YWL +N
Sbjct: 442 -----------LTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473
>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
Length = 452
Score = 244 bits (624), Expect = 1e-64
Identities = 153/458 (33%), Positives = 230/458 (50%), Gaps = 30/458 (6%)
Query: 49 LLSEETKSTET--ETGSRVGKLPEASRI--LNTILSNYDHKLRPGIGEKPTVVTVEISVN 104
L +++ + T + G VG E S + L+ +++ Y RPGIG P V + + V
Sbjct: 14 LCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALALEVA 73
Query: 105 SLGPLSILDMEYTIDIIFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTH 164
S+ +S +MEYT+ + Q+W D RL YN T E+L L+ V +LW+PDTF N+K
Sbjct: 74 SIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAW 133
Query: 165 EHEITMPNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMI 224
H++T+ N+++R+ DG +LY+IR+T C + + ++PMD C L S+ Y +++
Sbjct: 134 FHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIV 193
Query: 225 YKWENFKLEINEKNSWKLFQFDFTGVSNKTEIIT-TPVGDFMVMTIFFNVSRRFGYVAFQ 283
Y W + I+ + +L QF T TE++ G F +++ F++ R G Q
Sbjct: 194 YYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQ 253
Query: 284 NYVPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFY 343
+Y+PS + +SWVSFWI + PAR SLGIT+VLTMTTL +R + PR S I ALD Y
Sbjct: 254 SYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVY 313
Query: 344 IAICFVFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQE 403
IC+VF F AL+E+A +F + K A K+ PR S + A QE
Sbjct: 314 FWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQE 373
Query: 404 AFVCQIVTTEGSDGEERPSCSAQQPPSPGSPEGP-RSLCSKLACCEWCKRFKKYFCMVPD 462
+ S +Q PG+ G RS+ + KK
Sbjct: 374 LAI-----------------SRRQRRVPGNLMGSYRSVGVETG------ETKKEGAARSG 410
Query: 463 CEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYW 500
+G + R I +D Y+R VFP F NV+YW
Sbjct: 411 GQGGIRARLR-PIDADTIDIYARAVFPAAFAAVNVIYW 447
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 239 bits (611), Expect = 3e-63
Identities = 109/294 (37%), Positives = 178/294 (60%)
Query: 75 LNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLCYN 134
++ +L YD +LRP G P V + I + S+ +S ++M+YT+ + F Q W D+RL YN
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 135 DTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTIDAG 194
+L L+ V QLW+PDT+F N K++ H +T+ N+M+R++ DG VLY +R+T A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
Query: 195 CSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKT 254
C + + R+P+D +C L S+ Y +++ + W + +L QF T
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219
Query: 255 EIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGI 314
+ + G + +++ F + R GY Q Y+PS + T+LSWVSFWI +++ AR +LGI
Sbjct: 220 KKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 279
Query: 315 TSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQ 368
T+VLTMTT+ T R+ P++ Y+ A+D Y+ CFVF F ALLE+A++N++ + +
Sbjct: 280 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGR 333
Score = 39.7 bits (91), Expect = 0.007
Identities = 15/29 (51%), Positives = 21/29 (72%)
Query: 477 VYRLDNYSRVVFPVTFFFFNVLYWLVCLN 505
V +D +SR+ FPV F FFN++YWL +N
Sbjct: 484 VNAIDRWSRIFFPVVFSFFNIVYWLYYVN 512
>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 449
Score = 236 bits (602), Expect = 4e-62
Identities = 150/459 (32%), Positives = 230/459 (50%), Gaps = 56/459 (12%)
Query: 56 STETETGSRVGKLPEASRILNTIL---SNYDHKLRPGIGEKPTVVTVEISVNSLGPLSIL 112
S E E K S L+ ++ S YD ++RP P V+ I +NS G ++
Sbjct: 23 SKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAET 82
Query: 113 DMEYTIDIIFSQTWYDERLCYND-TFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMP 171
M+Y ++I Q W D RL YN+ +SL L+ +++ +W PD FF N K H HEIT
Sbjct: 83 TMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTD 142
Query: 172 NQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFK 231
N+++RI ++G VLY+IR+T+ C + + FPMD +C + SF Y N++I++W+ +
Sbjct: 143 NKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE-Q 201
Query: 232 LEINEKNSWKLFQF---DFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPS 288
+ + L QF + + T+ T G F + F++ R+ GY Q Y+PS
Sbjct: 202 GAVQVADGLTLPQFILKEEKDLRYCTKHYNT--GKFTCIEARFHLERQMGYYLIQMYIPS 259
Query: 289 SVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICF 348
+ +LSW+SFWI ++APAR LGIT+VLTMTT + SR + P+VSY+ A+D ++A+C
Sbjct: 260 LLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 319
Query: 349 VFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQ 408
+F F ALLE+A +NF+ + +L R R H A R + A+
Sbjct: 320 LFVFSALLEYAAVNFV------SRQHKELLRFRRKRRHHKEDEAGE---GRFNFSAYGMG 370
Query: 409 IVTTEGSDG----EERPSCSAQQPPSPG-SPEGPRSLCSKLACCEWCKRFKKYFCMVPDC 463
+ DG S + PP+P SPE R L + +R KK
Sbjct: 371 PACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKL--------FIQRAKK-------- 414
Query: 464 EGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLV 502
+D SR+ FP+ F FN+ YW++
Sbjct: 415 ----------------IDKISRIGFPMAFLIFNMFYWII 437
>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
Length = 452
Score = 236 bits (602), Expect = 4e-62
Identities = 142/453 (31%), Positives = 227/453 (50%), Gaps = 47/453 (10%)
Query: 55 KSTETETGSRVGKLPEASRILNTIL---SNYDHKLRPGIGEKPTVVTVEISVNSLGPLSI 111
K ++ +G + + S L+ ++ S YD ++RP P VT I +NS G ++
Sbjct: 28 KDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAE 87
Query: 112 LDMEYTIDIIFSQTWYDERLCYND-TFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITM 170
M+Y ++I Q W D RL Y++ +SL L+ +++ +W PD FF N K + H++T
Sbjct: 88 TTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTT 147
Query: 171 PNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW-EN 229
N+++RI K+GKVLY+IR+T+ C + + FPMD +C + SF Y N++I++W +
Sbjct: 148 DNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSD 207
Query: 230 FKLEINEKNSWKLFQF-DFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPS 288
+++ E + F + + T+ T G F + + F++ R+ GY Q Y+PS
Sbjct: 208 GPVQVAEGLTLPQFILKEEKELGYCTKHYNT--GKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 289 SVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICF 348
+ +LSWVSFWI ++APAR +LGIT+VLTMTT + SR + P+VSY+ A+D ++A+C
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 349 VFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQ 408
+F F ALLE+A +NF + Q K + R R N +R
Sbjct: 326 LFVFAALLEYAAVNF-VSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHC---- 380
Query: 409 IVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTW 468
+ +G+ + P+ QPP G KK F
Sbjct: 381 LQVKDGTAVKATPANPLPQPPKDGD------------------AIKKKF----------- 411
Query: 469 QQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWL 501
R+D SR FP+ F FN+ YW+
Sbjct: 412 -----VDRAKRIDTISRAAFPLAFLIFNIFYWI 439
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 236 bits (601), Expect = 5e-62
Identities = 142/453 (31%), Positives = 227/453 (50%), Gaps = 47/453 (10%)
Query: 55 KSTETETGSRVGKLPEASRILNTIL---SNYDHKLRPGIGEKPTVVTVEISVNSLGPLSI 111
K ++ +G + + S L+ ++ S YD ++RP P VT I +NS G ++
Sbjct: 28 KDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTE 87
Query: 112 LDMEYTIDIIFSQTWYDERLCYND-TFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITM 170
M+Y ++I Q W D RL Y++ +SL L+ +++ +W PD FF N K + H++T
Sbjct: 88 TTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTT 147
Query: 171 PNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW-EN 229
N+++RI K+GKVLY+IR+T+ C + + FPMD +C + SF Y N++I++W +
Sbjct: 148 DNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSD 207
Query: 230 FKLEINEKNSWKLFQF-DFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPS 288
+++ E + F + + T+ T G F + + F++ R+ GY Q Y+PS
Sbjct: 208 GPVQVAEGLTLPQFILKEEKELGYCTKHYNT--GKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 289 SVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICF 348
+ +LSWVSFWI ++APAR +LGIT+VLTMTT + SR + P+VSY+ A+D ++A+C
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 349 VFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQ 408
+F F ALLE+A +NF + Q K + R R N +R
Sbjct: 326 LFVFAALLEYAAVNF-VSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHC---- 380
Query: 409 IVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTW 468
+ +G+ + P+ QPP G KK F
Sbjct: 381 LQVKDGTAVKATPANPLPQPPKDGD------------------AIKKKF----------- 411
Query: 469 QQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWL 501
R+D SR FP+ F FN+ YW+
Sbjct: 412 -----VDRAKRIDTISRAAFPLAFLIFNIFYWI 439
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 236 bits (601), Expect = 5e-62
Identities = 142/453 (31%), Positives = 227/453 (50%), Gaps = 47/453 (10%)
Query: 55 KSTETETGSRVGKLPEASRILNTIL---SNYDHKLRPGIGEKPTVVTVEISVNSLGPLSI 111
K ++ +G + + S L+ ++ S YD ++RP P VT I +NS G ++
Sbjct: 28 KDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTE 87
Query: 112 LDMEYTIDIIFSQTWYDERLCYND-TFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITM 170
M+Y ++I Q W D RL Y++ +SL L+ +++ +W PD FF N K + H++T
Sbjct: 88 TTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTT 147
Query: 171 PNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKW-EN 229
N+++RI K+GKVLY+IR+T+ C + + FPMD +C + SF Y N++I++W +
Sbjct: 148 DNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSD 207
Query: 230 FKLEINEKNSWKLFQF-DFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPS 288
+++ E + F + + T+ T G F + + F++ R+ GY Q Y+PS
Sbjct: 208 GPVQVAEGLTLPQFILKEEKELGYCTKHYNT--GKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 289 SVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICF 348
+ +LSWVSFWI ++APAR +LGIT+VLTMTT + SR + P+VSY+ A+D ++A+C
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 349 VFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQ 408
+F F ALLE+A +NF + Q K + R R N +R
Sbjct: 326 LFVFAALLEYAAVNF-VSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHC---- 380
Query: 409 IVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTW 468
+ +G+ + P+ QPP G KK F
Sbjct: 381 LQVKDGTAVKATPANPLPQPPKDGD------------------AIKKKF----------- 411
Query: 469 QQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWL 501
R+D SR FP+ F FN+ YW+
Sbjct: 412 -----VDRAKRIDTISRAAFPLAFLIFNIFYWI 439
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 235 bits (599), Expect = 8e-62
Identities = 149/468 (31%), Positives = 234/468 (50%), Gaps = 66/468 (14%)
Query: 56 STETETGSRVGKLPEASRILNTIL---SNYDHKLRPGIGEKPTVVTVEISVNSLGPLSIL 112
S E E K S L+ ++ S YD ++RP P V+ I +NS G ++
Sbjct: 23 SKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAET 82
Query: 113 DMEYTIDIIFSQTWYDERLCYND-TFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMP 171
M+Y ++I Q W D RL YN+ +SL L+ +++ +W PD FF N K H HEIT
Sbjct: 83 TMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTD 142
Query: 172 NQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFK 231
N+++RI ++G VLY+IR+T+ C + + FPMD +C + SF Y N++I++W+ +
Sbjct: 143 NKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE-Q 201
Query: 232 LEINEKNSWKLFQF---DFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPS 288
+ + L QF + + T+ T G F + F++ R+ GY Q Y+PS
Sbjct: 202 GAVQVADGLTLPQFILKEEKDLRYCTKHYNT--GKFTCIEARFHLERQMGYYLIQMYIPS 259
Query: 289 SVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICF 348
+ +LSW+SFWI ++APAR LGIT+VLTMTT + SR + P+VSY+ A+D ++A+C
Sbjct: 260 LLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 319
Query: 349 VFCFCALLEFAVLNFL---------IYNQTKAHASPKLRHPRINSRAHAR----TRARSR 395
+F F ALLE+A +NF+ + + H SP L + + R
Sbjct: 320 LFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGP 379
Query: 396 ACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPG-SPEGPRSLCSKLACCEWCKRFK 454
AC + ++ +G++ S + PP+P SPE R L + +R K
Sbjct: 380 ACLQAKDG------ISVKGANN----SNTTNPPPAPSKSPEEMRKL--------FIQRAK 421
Query: 455 KYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLV 502
K +D SR+ FP+ F FN+ YW++
Sbjct: 422 K------------------------IDKISRIGFPMAFLIFNMFYWII 445
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,931,716
Number of Sequences: 37866
Number of extensions: 911575
Number of successful extensions: 3764
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 3611
Number of HSP's gapped (non-prelim): 134
length of query: 506
length of database: 18,247,518
effective HSP length: 107
effective length of query: 399
effective length of database: 14,195,856
effective search space: 5664146544
effective search space used: 5664146544
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.