Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 5031633
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1
isoform 1 [Homo sapiens]
(1045 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 2108 0.0
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 1121 0.0
gi|34916000 FERM domain containing 7 [Homo sapiens] 431 e-120
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 268 3e-71
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 267 4e-71
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 267 4e-71
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 267 4e-71
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 262 1e-69
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 261 2e-69
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 261 2e-69
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 256 8e-68
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 256 8e-68
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 229 1e-59
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 223 1e-57
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 216 9e-56
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 211 3e-54
gi|117500790 FERM domain containing 3 [Homo sapiens] 209 1e-53
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 208 2e-53
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 192 1e-48
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 192 1e-48
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 189 1e-47
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 165 2e-40
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens] 157 5e-38
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 142 2e-33
gi|4505257 moesin [Homo sapiens] 139 2e-32
gi|4506467 radixin [Homo sapiens] 136 9e-32
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 134 3e-31
gi|161702986 ezrin [Homo sapiens] 132 2e-30
gi|21614499 ezrin [Homo sapiens] 132 2e-30
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens] 127 5e-29
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 2108 bits (5463), Expect = 0.0
Identities = 1045/1045 (100%), Positives = 1045/1045 (100%)
Query: 1 MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRA 60
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRA
Sbjct: 1 MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRA 60
Query: 61 PGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFF 120
PGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFF
Sbjct: 61 PGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFF 120
Query: 121 PPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHL 180
PPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHL
Sbjct: 121 PPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHL 180
Query: 181 AKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKI 240
AKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKI
Sbjct: 181 AKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKI 240
Query: 241 NLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRD 300
NLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRD
Sbjct: 241 NLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRD 300
Query: 301 FCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQ 360
FCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQ
Sbjct: 301 FCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQ 360
Query: 361 FERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAG 420
FERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAG
Sbjct: 361 FERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAG 420
Query: 421 EPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHL 480
EPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHL
Sbjct: 421 EPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHL 480
Query: 481 SELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDK 540
SELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDK
Sbjct: 481 SELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDK 540
Query: 541 AYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLK 600
AYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLK
Sbjct: 541 AYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLK 600
Query: 601 EIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRR 660
EIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRR
Sbjct: 601 EIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRR 660
Query: 661 LENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEI 720
LENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEI
Sbjct: 661 LENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEI 720
Query: 721 TEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFF 780
TEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFF
Sbjct: 721 TEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFF 780
Query: 781 LFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASS 840
LFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASS
Sbjct: 781 LFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASS 840
Query: 841 RSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSL 900
RSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSL
Sbjct: 841 RSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSL 900
Query: 901 ERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFC 960
ERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFC
Sbjct: 901 ERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFC 960
Query: 961 LFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERW 1020
LFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERW
Sbjct: 961 LFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERW 1020
Query: 1021 MEVIRSATSSASRPHVLSHKESLVY 1045
MEVIRSATSSASRPHVLSHKESLVY
Sbjct: 1021 MEVIRSATSSASRPHVLSHKESLVY 1045
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 1121 bits (2900), Expect = 0.0
Identities = 577/1056 (54%), Positives = 737/1056 (69%), Gaps = 49/1056 (4%)
Query: 1 MGEIEQR----PTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEV 56
MGEIE T G RLGA G+STLE GQ P K + +++++LD+T E F++
Sbjct: 1 MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI 60
Query: 57 PQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFV 116
+ G+VLL V LNLVE DYFG+EF + + +WL+ +KPI++QIRRPK+VV++
Sbjct: 61 EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA 120
Query: 117 VKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALD 176
VKFFPPD QLQEE TRYLFALQ+K+DL + RLTC DT+AALL SH++QSEIGD+DE LD
Sbjct: 121 VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD 180
Query: 177 REHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDRE 236
REHL N+Y+P Q +KI+EFH H+GQTPAESDFQ+LEIAR+LEMYGIR H A DRE
Sbjct: 181 REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE 240
Query: 237 GTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLM 296
GTKI LAV++ G+LVFQG TKIN FNW+KVRKLSFKRKRFLIKL P+ + YQDTLEFL+
Sbjct: 241 GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL 300
Query: 297 ASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGH 356
SRD CK+FWKICVE+H FFRL ++PKPK K V FSRGSSFR+SGRTQKQ++DY K+ G
Sbjct: 301 GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM 360
Query: 357 KKVQFERKHSKIH-SIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRR---- 411
K++ +ER+HSK H S+R+L + S++F EG +P S
Sbjct: 361 KRIPYERRHSKTHTSVRALTA------------DLPKQSISFPEGLRTPASPSSANAFYS 408
Query: 412 -GKEPKVSAGEPG--------SHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQS 462
V +G P + P + +SPA +++ A P Q
Sbjct: 409 LSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPS-------AQPL 461
Query: 463 KPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQAC 522
P QP G T SP S S S ++PA L P + +SPL+SP+L+D
Sbjct: 462 GPPALQPGPGLSTKSPQPSPSSRKSPLSLSPA---FQVPLGPAEQGSSPLLSPVLSDAGG 518
Query: 523 PRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKS 582
D E E R KR P D+AYFI KE+ TERTYLKDLEVIT WF+S V KEDAMP L +
Sbjct: 519 AGMDCE-EPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMT 577
Query: 583 LIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIR-DYQRIGDVMLKNIQGMKHLAAHL 641
L+F N +P+++FH FL+E+EQRLALWEG S A + +QRIGD++L+N++ +K ++
Sbjct: 578 LLFSNIDPIYEFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYF 637
Query: 642 WKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCK 701
+H E L LE K ++LE ++FELQKVCYLPLNTFLL+P+ RL+HY+ +L RLC
Sbjct: 638 QRHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCG 697
Query: 702 HHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFI 761
H+ P H D+ DC AL ITE+ L +I++EN QKL EL++DL+GI+NL+ PGREFI
Sbjct: 698 HYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFI 757
Query: 762 RLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGV 821
R G L KL+ KGLQQRMFFLF+D+LLYTS+G+ ++ F++ G LPL GM +EES++EW V
Sbjct: 758 REGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSV 817
Query: 822 PHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEF----LASSPPDNK 877
PHC T+ +++I+VAAS+R E EKW+ D+ AI A+ AP + + PP +
Sbjct: 818 PHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPP--R 875
Query: 878 SPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSG 937
SP+E + +QESEDD R+SLE HR NT +HVCW+RNTSVS D S AVENQLSG
Sbjct: 876 SPNE-VSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSG 934
Query: 938 NLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYV 997
LLRKFKNS+GWQKLWVVFTNFCLFFYK+HQD++PLASLPLLGYS++IP E++ I KDYV
Sbjct: 935 YLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYV 994
Query: 998 FKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASR 1033
FKL FKSHVY+FRAES+YTFERWMEVI+ A+SSA R
Sbjct: 995 FKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGR 1030
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 431 bits (1107), Expect = e-120
Identities = 231/443 (52%), Positives = 299/443 (67%), Gaps = 22/443 (4%)
Query: 39 LVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLL 98
++ +K+Q LDD+Q+ F V Q++ GK L + C+HLNL E +YFGLEF H VWL+LL
Sbjct: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60
Query: 99 KPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAAL 158
KPI KQ++ PK +V KF+VKFFP D L+EELTRYLF LQ+K+DLA GRL C+D AL
Sbjct: 61 KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120
Query: 159 LISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEI 218
++SHI+QSE+GDF E DR+HLA+ +Y+P QD LE KI+ FH HIG++PAESD LL+I
Sbjct: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180
Query: 219 ARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLI 278
AR+L+MYGIR HPA D EG +I+LAVA+ G+LV +G TKIN FNWAK+RKLSFKRK FLI
Sbjct: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
Query: 279 KLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFR 338
KL + +DTLEF MASRD CK+FWK CVE+HAFFRL EEPK KPK +L S+GSSFR
Sbjct: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
Query: 339 FSGRTQKQVLDYVKEGGHKKVQFERKH--SKIHSIRSLASQPTELNSEVLEQSQQSTSLT 396
+SGRTQ+Q+L+Y ++G K + FERKH S+ H R S P +L S+V +Q + L
Sbjct: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHE-RQCRSSP-DLLSDVSKQ-VEDLRLA 357
Query: 397 FGEG---------AESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAP 447
+G G A P +S RR +V+ H P P Q+ ++S P
Sbjct: 358 YGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSK--PEADPTLLHQSQSSSSFP 415
Query: 448 TEEEEEVVKDRTQQSKPQP-PQP 469
+ D ++P P P P
Sbjct: 416 F-----IYMDPVFNTEPNPNPDP 433
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 268 bits (684), Expect = 3e-71
Identities = 161/423 (38%), Positives = 237/423 (56%), Gaps = 14/423 (3%)
Query: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
K + K+ +LD ++ +V +R+ G+VL D VC HLNL+E DYFGL + D + WLD
Sbjct: 108 KSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDP 167
Query: 98 LKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAA 157
K I KQ+R F VKF+PPD QL E++TRY LQ++ D+ GRL C+ + A
Sbjct: 168 AKEIKKQVRSGAWHF-SFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLA 226
Query: 158 LLISHIVQSEIGDFD-EALDREHLAKNKYIPQQDA-LEDKIVEFHHNHIGQTPAESDFQL 215
LL S+ VQSE+GD+D + +++++ ++ P LEDK++E H +H G TPAE++
Sbjct: 227 LLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHF 286
Query: 216 LEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKR 275
LE A++L MYG+ LH AKD EG +I L V +G+L+++ +IN F W KV K+S+KR
Sbjct: 287 LENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNN 346
Query: 276 FLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGS 335
F IK+RP ++ T+ F + + K WK+CVEHH FFRL P+ PK L + GS
Sbjct: 347 FYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLL-LPEAPPKKFL-TLGS 404
Query: 336 SFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSI-RSLASQ---PTELNSEVLEQSQQ 391
FR+SGRTQ Q FER SK +++ RSL + ++ + Q+
Sbjct: 405 KFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNL 464
Query: 392 STSLTFGEGAESPGGQ---SCRRGKE--PKVSAGEPGSHPSPAPRRSPAGNKQADGAASA 446
T++T + AE + R+G+E P + G P P A ++
Sbjct: 465 ITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTS 524
Query: 447 PTE 449
PTE
Sbjct: 525 PTE 527
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 267 bits (682), Expect = 4e-71
Identities = 149/350 (42%), Positives = 207/350 (59%), Gaps = 11/350 (3%)
Query: 34 TPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITV 93
T K V K+ +LD T+ + ++ + A G+VL D VC HLNL+E DYFGL F + +
Sbjct: 212 TKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271
Query: 94 WLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCND 153
WLD K I +Q+R + F VKF+PPD +QL E++TRY LQ++QD+A GRL C+
Sbjct: 272 WLDPAKEIKRQLRNLPWLFT-FNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSF 330
Query: 154 TSAALLISHIVQSEIGDFDEALDREH----LAKNKYIPQQDA-LEDKIVEFHHNHIGQTP 208
+ ALL S+ +Q+E+GD+D EH L++ ++ P Q LE+K+ E H H G +P
Sbjct: 331 VTHALLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSP 387
Query: 209 AESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRK 268
A++D Q LE A+RL MYG+ LH AKD EG I L V G+L+++ +IN F W K+ K
Sbjct: 388 AQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILK 447
Query: 269 LSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKP 328
+S+KR F IK+RP ++ T+ F + + K WK+CVEHH F+RL P+ PK
Sbjct: 448 ISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKA 506
Query: 329 VLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQP 378
+ GS FR+SGRTQ Q FER SK S RSL P
Sbjct: 507 KFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS-RSLDGAP 555
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 267 bits (682), Expect = 4e-71
Identities = 149/350 (42%), Positives = 207/350 (59%), Gaps = 11/350 (3%)
Query: 34 TPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITV 93
T K V K+ +LD T+ + ++ + A G+VL D VC HLNL+E DYFGL F + +
Sbjct: 212 TKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271
Query: 94 WLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCND 153
WLD K I +Q+R + F VKF+PPD +QL E++TRY LQ++QD+A GRL C+
Sbjct: 272 WLDPAKEIKRQLRNLPWLFT-FNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSF 330
Query: 154 TSAALLISHIVQSEIGDFDEALDREH----LAKNKYIPQQDA-LEDKIVEFHHNHIGQTP 208
+ ALL S+ +Q+E+GD+D EH L++ ++ P Q LE+K+ E H H G +P
Sbjct: 331 VTHALLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSP 387
Query: 209 AESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRK 268
A++D Q LE A+RL MYG+ LH AKD EG I L V G+L+++ +IN F W K+ K
Sbjct: 388 AQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILK 447
Query: 269 LSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKP 328
+S+KR F IK+RP ++ T+ F + + K WK+CVEHH F+RL P+ PK
Sbjct: 448 ISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKA 506
Query: 329 VLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQP 378
+ GS FR+SGRTQ Q FER SK S RSL P
Sbjct: 507 KFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS-RSLDGAP 555
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 267 bits (682), Expect = 4e-71
Identities = 149/350 (42%), Positives = 207/350 (59%), Gaps = 11/350 (3%)
Query: 34 TPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITV 93
T K V K+ +LD T+ + ++ + A G+VL D VC HLNL+E DYFGL F + +
Sbjct: 212 TKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271
Query: 94 WLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCND 153
WLD K I +Q+R + F VKF+PPD +QL E++TRY LQ++QD+A GRL C+
Sbjct: 272 WLDPAKEIKRQLRNLPWLFT-FNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSF 330
Query: 154 TSAALLISHIVQSEIGDFDEALDREH----LAKNKYIPQQDA-LEDKIVEFHHNHIGQTP 208
+ ALL S+ +Q+E+GD+D EH L++ ++ P Q LE+K+ E H H G +P
Sbjct: 331 VTHALLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSP 387
Query: 209 AESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRK 268
A++D Q LE A+RL MYG+ LH AKD EG I L V G+L+++ +IN F W K+ K
Sbjct: 388 AQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILK 447
Query: 269 LSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKP 328
+S+KR F IK+RP ++ T+ F + + K WK+CVEHH F+RL P+ PK
Sbjct: 448 ISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKA 506
Query: 329 VLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQP 378
+ GS FR+SGRTQ Q FER SK S RSL P
Sbjct: 507 KFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS-RSLDGAP 555
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 262 bits (669), Expect = 1e-69
Identities = 145/334 (43%), Positives = 202/334 (60%), Gaps = 7/334 (2%)
Query: 40 VSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITV-WLDLL 98
V I +LD+T +AF+V + G+VLLD V HL+L E DYFGL+ D WLD
Sbjct: 29 VVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPN 88
Query: 99 KPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAAL 158
KPI KQ++R + F VKFF D +LQEE TRY + LQ+KQD+ GRL C +AAL
Sbjct: 89 KPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAAL 148
Query: 159 LISHIVQSEIGDFDEALDRE-HLAKNKYIPQQDA-LEDKIVEFHHNHIGQTPAESDFQLL 216
L S VQSE+GD+D++ + +L+ +IP Q E +I + H HIG +PAE++F L
Sbjct: 149 LASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYL 208
Query: 217 EIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF 276
AR LE+YG+ H A+D+ +I + V + GIL+++ ++N F W K+ K+SFK K+F
Sbjct: 209 NTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQF 268
Query: 277 LIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVL---FSR 333
I+LR + + + + L F M + CK+ WK CVEHH FFRL + P P K F+
Sbjct: 269 FIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTL 327
Query: 334 GSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSK 367
GS FR+ GRT+ Q + Y KE +K F R SK
Sbjct: 328 GSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK 361
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 261 bits (667), Expect = 2e-69
Identities = 150/362 (41%), Positives = 208/362 (57%), Gaps = 5/362 (1%)
Query: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102
K+ +LDDT V + A G+ LL VC HLNL+E DYFGL D+ WLD K I
Sbjct: 4 KVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIK 63
Query: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162
KQ+R F VKF+PPD QL E++TRY LQ++QD+ GRL C+ + ALL S+
Sbjct: 64 KQVRGVPWNFT-FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
Query: 163 IVQSEIGDFDEALDR-EHLAKNKYIPQQDA-LEDKIVEFHHNHIGQTPAESDFQLLEIAR 220
+QSE+GD+D L ++++ K P Q LE+K++E H ++ TPA++D + LE A+
Sbjct: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
Query: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKL 280
+L MYG+ LH AKD EG I L V ++G+LV++ +IN F W KV K+S+KR F IK+
Sbjct: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
Query: 281 RPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFS 340
RP Y+ T+ F + S K WK+CVEHH FFRL PK + GS FR+S
Sbjct: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL-TSTDTIPKSKFLALGSKFRYS 301
Query: 341 GRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEG 400
GRTQ Q FER SK + RSL +++ + + ++T G+
Sbjct: 302 GRTQAQTRQASALIDRPAPHFERTASK-RASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 401 AE 402
AE
Sbjct: 361 AE 362
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 261 bits (667), Expect = 2e-69
Identities = 150/362 (41%), Positives = 208/362 (57%), Gaps = 5/362 (1%)
Query: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102
K+ +LDDT V + A G+ LL VC HLNL+E DYFGL D+ WLD K I
Sbjct: 4 KVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIK 63
Query: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162
KQ+R F VKF+PPD QL E++TRY LQ++QD+ GRL C+ + ALL S+
Sbjct: 64 KQVRGVPWNFT-FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
Query: 163 IVQSEIGDFDEALDR-EHLAKNKYIPQQDA-LEDKIVEFHHNHIGQTPAESDFQLLEIAR 220
+QSE+GD+D L ++++ K P Q LE+K++E H ++ TPA++D + LE A+
Sbjct: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
Query: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKL 280
+L MYG+ LH AKD EG I L V ++G+LV++ +IN F W KV K+S+KR F IK+
Sbjct: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
Query: 281 RPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFS 340
RP Y+ T+ F + S K WK+CVEHH FFRL PK + GS FR+S
Sbjct: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL-TSTDTIPKSKFLALGSKFRYS 301
Query: 341 GRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEG 400
GRTQ Q FER SK + RSL +++ + + ++T G+
Sbjct: 302 GRTQAQTRQASALIDRPAPHFERTASK-RASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 401 AE 402
AE
Sbjct: 361 AE 362
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 256 bits (654), Expect = 8e-68
Identities = 148/357 (41%), Positives = 207/357 (57%), Gaps = 8/357 (2%)
Query: 23 STLERGQKPPPTPSGKLVSI--KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDY 80
+T + QK P + K S ++ +LD ++ EV + G+VL D VC HLNL+E DY
Sbjct: 16 TTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDY 75
Query: 81 FGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQV 140
FGL F D WLD K I KQIR F VKF+PPD QL E++TRY LQ+
Sbjct: 76 FGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFA-FTVKFYPPDPAQLTEDITRYYLCLQL 134
Query: 141 KQDLAQGRLTCNDTSAALLISHIVQSEIGDFD-EALDREHLAKNKYIPQQDA-LEDKIVE 198
+ D+ GRL C+ + ALL S+ VQ+E+GD+D E ++++ ++ P Q LE++I+E
Sbjct: 135 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 194
Query: 199 FHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKI 258
H + G TP E++ LE A++L MYG+ LH AKD EG I L V G+L+++ +I
Sbjct: 195 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 254
Query: 259 NAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRL 318
N F W K+ K+S+KR F IK+RP ++ T+ F + + K WK+C+EHH FFRL
Sbjct: 255 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 314
Query: 319 FEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSI-RSL 374
P+P PK L GS FR+SGRTQ Q FER SK +++ RSL
Sbjct: 315 V-SPEPPPKGFLV-MGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 369
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 256 bits (654), Expect = 8e-68
Identities = 148/357 (41%), Positives = 207/357 (57%), Gaps = 8/357 (2%)
Query: 23 STLERGQKPPPTPSGKLVSI--KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDY 80
+T + QK P + K S ++ +LD ++ EV + G+VL D VC HLNL+E DY
Sbjct: 78 TTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDY 137
Query: 81 FGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQV 140
FGL F D WLD K I KQIR F VKF+PPD QL E++TRY LQ+
Sbjct: 138 FGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFA-FTVKFYPPDPAQLTEDITRYYLCLQL 196
Query: 141 KQDLAQGRLTCNDTSAALLISHIVQSEIGDFD-EALDREHLAKNKYIPQQDA-LEDKIVE 198
+ D+ GRL C+ + ALL S+ VQ+E+GD+D E ++++ ++ P Q LE++I+E
Sbjct: 197 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 256
Query: 199 FHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKI 258
H + G TP E++ LE A++L MYG+ LH AKD EG I L V G+L+++ +I
Sbjct: 257 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 316
Query: 259 NAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRL 318
N F W K+ K+S+KR F IK+RP ++ T+ F + + K WK+C+EHH FFRL
Sbjct: 317 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 376
Query: 319 FEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSI-RSL 374
P+P PK L GS FR+SGRTQ Q FER SK +++ RSL
Sbjct: 377 V-SPEPPPKGFLV-MGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 431
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 229 bits (584), Expect = 1e-59
Identities = 139/394 (35%), Positives = 211/394 (53%), Gaps = 9/394 (2%)
Query: 31 PPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKK 90
P S +++ ++ +LD T + ++P++A G+ L D + HL+L+E DYFGL F D +
Sbjct: 34 PAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQ 93
Query: 91 ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLT 150
+ WLD K I KQ++ + VKF+ + L+EELTRYLF LQ+KQD+ G+L
Sbjct: 94 VAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLD 153
Query: 151 CNDTSAALLISHIVQSEIGDFDEALDREHLAKN-KYIP-QQDALEDKIVEFHHNHIGQTP 208
C +A L ++ +Q+E+GD+D A L +++P Q + +E I E + GQTP
Sbjct: 154 CPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTP 213
Query: 209 AESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRK 268
A+++ L A+ LEMYG+ +H K R+G +L + TG+LVF+G TKI F W K+ +
Sbjct: 214 AQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITR 273
Query: 269 LSFKRKRF-LIKLRPDANSAYQD-TLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKP 326
L FK+ + L+ + D Q+ T F + CK WK VEHHAFFRL +
Sbjct: 274 LDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSS 333
Query: 327 KPVLFSR-GSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEV 385
F R GS FR+SG+T+ Q K + FER+ SK +S R+L + E
Sbjct: 334 HRSGFIRLGSRFRYSGKTEYQTTKTNK--ARRSTSFERRPSKRYSRRTLQMKACATKPE- 390
Query: 386 LEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSA 419
E S + T G++ G P +S+
Sbjct: 391 -ELSVHNNVSTQSNGSQQAWGMRSALPVSPSISS 423
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 223 bits (567), Expect = 1e-57
Identities = 138/375 (36%), Positives = 201/375 (53%), Gaps = 11/375 (2%)
Query: 91 ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLT 150
+ WLD K I KQ+R F VKF+PPD QL E++TRY LQ++QD+ GRL
Sbjct: 226 VETWLDSAKEIKKQVRGVPWNFT-FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284
Query: 151 CNDTSAALLISHIVQSEIGDFDEALDR-EHLAKNKYIPQQDA-LEDKIVEFHHNHIGQTP 208
C+ + ALL S+ +QSE+GD+D L ++++ K P Q LE+K++E H ++ TP
Sbjct: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344
Query: 209 AESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRK 268
A++D + LE A++L MYG+ LH AKD EG I L V ++G+LV++ +IN F W KV K
Sbjct: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404
Query: 269 LSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKP 328
+S+KR F IK+RP Y+ T+ F + S K WK+CVEHH FFRL PK
Sbjct: 405 ISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL-TSTDTIPKS 463
Query: 329 VLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQ 388
+ GS FR+SGRTQ Q FER SK + RSL +++ +
Sbjct: 464 KFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASK-RASRSLDGAAAVDSADRSPR 522
Query: 389 SQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPT 448
+ ++T G+ AE GG K+ V P + ++ + A PT
Sbjct: 523 PTSAPAITQGQVAE--GGVLDASAKKTVV----PKAQKETVKAEVKKEDEPPEQAEPEPT 576
Query: 449 EEEEEVVKDRTQQSK 463
E +++ K + + K
Sbjct: 577 EAWKDLDKSQEEIKK 591
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 216 bits (550), Expect = 9e-56
Identities = 131/374 (35%), Positives = 205/374 (54%), Gaps = 20/374 (5%)
Query: 41 SIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKP 100
S +++LDD++ + + A G+ L D +C+HLNL+E DYFG+ F D K WL+ K
Sbjct: 18 SCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKS 77
Query: 101 IVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLI 160
+VKQ+R + F VKF+P D L+EE+TRYL LQ+K+DL GRL C + AALL
Sbjct: 78 VVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLA 137
Query: 161 SHIVQSEIGDFDEALDRE-HLAKNKYIPQ-QDALEDKIVEFHHNHI-GQTPAESDFQLLE 217
++I+Q+EIGD+D E + +K ++ P+ + LE KI E H + GQTPA S+ L
Sbjct: 138 AYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLR 197
Query: 218 IARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFL 277
A+ LE YG+ HP KD G LA G +V QG +++ W +V KL F+ K F
Sbjct: 198 KAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFY 257
Query: 278 IKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPK--PKPVLFSRGS 335
+ + + L + + + CK WK +E+ AF++L + + + LF +GS
Sbjct: 258 LYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGS 315
Query: 336 SFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQ--PTELN----SEVLEQS 389
FR+SGR K+V++ + +R+ +IH + S+ P+ + S V
Sbjct: 316 RFRYSGRVAKEVME-------SSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTR 368
Query: 390 QQSTSLTFGEGAES 403
+++ ++ EG ES
Sbjct: 369 RRAVHISIMEGLES 382
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 211 bits (537), Expect = 3e-54
Identities = 140/426 (32%), Positives = 225/426 (52%), Gaps = 18/426 (4%)
Query: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102
++ +LD T+ + ++P+ A G+ L D + HL+LVE DYFGL+F D ++ WLD KPI
Sbjct: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
Query: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162
KQ++ + F VK++ + L+EE TRYLF LQ++ D+ G+L C +A L +
Sbjct: 148 KQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAAL 207
Query: 163 IVQSEIGDFD-EALDREHLAKNKYIPQQ-DALEDKIVEFHHNHIGQTPAESDFQLLEIAR 220
+Q+E+G+ + E +++ ++IP Q +A+E I + G++PA+++ L A+
Sbjct: 208 CLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAK 267
Query: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF-LIK 279
LEMYG+ +H + R+G + +L + TGIL+F+G KI F W K+ K+ FK+ + L+
Sbjct: 268 WLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVV 327
Query: 280 LRPDANSAYQD-TLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSR-GSSF 337
+ D Q+ T F + S CK WK VEHHAFFRL K F R GS F
Sbjct: 328 VEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRF 387
Query: 338 RFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTF 397
RFSGRT+ Q + + FERK SK + R ++ N + Q T
Sbjct: 388 RFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRRHSTFKAS-NPVIAAQLCSKT---- 440
Query: 398 GEGAESPGGQSCRRGKEPKVSAGEPGSHP-SPAPRRSPAGNKQADGAASAPTEEEEEVVK 456
+P + + P + +P HP SP R S ++ A+++ + + V
Sbjct: 441 -----NPEVHNYQPQYHPNIHPSQPRWHPHSPNVRPSFQDDRSHWKASASGDDSHFDYVH 495
Query: 457 DRTQQS 462
D+ Q++
Sbjct: 496 DQNQKN 501
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 209 bits (532), Expect = 1e-53
Identities = 143/425 (33%), Positives = 221/425 (52%), Gaps = 34/425 (8%)
Query: 44 IQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVK 103
I++LDD++ + + + G+ L+D +CN+ +L+E DYFG+ + D +K WL+ K I K
Sbjct: 36 IRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFK 95
Query: 104 QIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHI 163
Q++ + F VKF+P + +++EELTRYL LQ+K+D+ GRL C+ + AA L + I
Sbjct: 96 QMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACI 155
Query: 164 VQSEIGDFD-EALDREHLAKNKYIPQQ-DALEDKIVEFHHNHI-GQTPAESDFQLLEIAR 220
VQ+E+GD+D + ++++ + P+Q LE KIVE H N + GQ+P ++F LL A
Sbjct: 156 VQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAH 215
Query: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKL 280
LE YG+ HP KD GT L G +VFQG +I+ W V KL F+ K F +
Sbjct: 216 TLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIG 275
Query: 281 RPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPK--PKPVLFSRGSSFR 338
A L F ++ CK WK VE+ AF++ + + K +F +GS FR
Sbjct: 276 TQKEKKA---MLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFR 332
Query: 339 FSGRTQKQVLDYVKEGGHKKVQFERKH-SKIHSIRSLASQPTELNSEVLE-----QSQQS 392
+SG+ K+V++ + + + R + ++ S SL Q +N E L+ S+Q
Sbjct: 333 YSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQ-LIINMEPLQPLLPSPSEQE 391
Query: 393 TSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEE 452
L GEG P KE +SA S P A R P EEE
Sbjct: 392 EELPLGEGVPLP--------KEENISAPLISSSPVKAARE-----------YEDPPSEEE 432
Query: 453 EVVKD 457
+ +K+
Sbjct: 433 DKIKE 437
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 208 bits (530), Expect = 2e-53
Identities = 124/335 (37%), Positives = 191/335 (57%), Gaps = 7/335 (2%)
Query: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102
++ +LD T+ + ++P+ A G+ L D + HL+LVE DYFGL+F D ++ WLD KPI
Sbjct: 88 RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIK 147
Query: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162
KQ++ + F VK++ + L+EE TRYLF LQ++ D+ G+L C +A L +
Sbjct: 148 KQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAAL 207
Query: 163 IVQSEIGDFD-EALDREHLAKNKYIPQQ-DALEDKIVEFHHNHIGQTPAESDFQLLEIAR 220
+Q+E+G+ + E +++ ++IP Q +A+E I + G++PA+++ L A+
Sbjct: 208 CLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAK 267
Query: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF-LIK 279
LEMYG+ +H + R+G + +L + TGIL+F+G KI F W K+ K+ FK+ + L+
Sbjct: 268 WLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVV 327
Query: 280 LRPDANSAYQD-TLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSR-GSSF 337
+ D Q+ T F + S CK WK VEHHAFFRL K F R GS F
Sbjct: 328 VEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRF 387
Query: 338 RFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIR 372
RFSGRT+ Q + + FERK SK + R
Sbjct: 388 RFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSR 420
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 192 bits (488), Expect = 1e-48
Identities = 109/309 (35%), Positives = 172/309 (55%), Gaps = 8/309 (2%)
Query: 27 RGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFP 86
R + P + V I LD + F+V ++ G+VLLD V NHL + E +YFGL+
Sbjct: 16 RTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHD 75
Query: 87 DHKKITV-WLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLA 145
D + WL+ K I KQ++ + F V+FF PD LQ+E TR+L+ LQ+K D+
Sbjct: 76 DDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDIC 135
Query: 146 QGRLTCNDTSAALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQDALED---KIVEFHH 201
+GRLTC SA +L S+ VQS GD++ ++ +L+ + +IP Q+ ED K+ H
Sbjct: 136 EGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN--EDFLTKVESLHE 193
Query: 202 NHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAF 261
H G +E++ + IAR L+ YG+ LH +D + + +A+ G+ V++ + + +
Sbjct: 194 QHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFY 253
Query: 262 NWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEE 321
W + K+SFKRK+F I R + + + F M + CK+ WK CVEHH FF+ ++
Sbjct: 254 PWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQA-KK 312
Query: 322 PKPKPKPVL 330
P+ K VL
Sbjct: 313 LLPQEKNVL 321
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 192 bits (488), Expect = 1e-48
Identities = 109/309 (35%), Positives = 172/309 (55%), Gaps = 8/309 (2%)
Query: 27 RGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFP 86
R + P + V I LD + F+V ++ G+VLLD V NHL + E +YFGL+
Sbjct: 16 RTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHD 75
Query: 87 DHKKITV-WLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLA 145
D + WL+ K I KQ++ + F V+FF PD LQ+E TR+L+ LQ+K D+
Sbjct: 76 DDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDIC 135
Query: 146 QGRLTCNDTSAALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQDALED---KIVEFHH 201
+GRLTC SA +L S+ VQS GD++ ++ +L+ + +IP Q+ ED K+ H
Sbjct: 136 EGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN--EDFLTKVESLHE 193
Query: 202 NHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAF 261
H G +E++ + IAR L+ YG+ LH +D + + +A+ G+ V++ + + +
Sbjct: 194 QHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFY 253
Query: 262 NWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEE 321
W + K+SFKRK+F I R + + + F M + CK+ WK CVEHH FF+ ++
Sbjct: 254 PWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQA-KK 312
Query: 322 PKPKPKPVL 330
P+ K VL
Sbjct: 313 LLPQEKNVL 321
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 189 bits (480), Expect = 1e-47
Identities = 119/355 (33%), Positives = 185/355 (52%), Gaps = 16/355 (4%)
Query: 43 KIQMLDDTQEAFEVPQRA-----PGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
++ +LD+++ Q+ G V+LD V +H+NLVE DYFGL + D T WLD
Sbjct: 14 EVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDP 73
Query: 98 LKPIVKQ---IRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDT 154
K + + I + F +KF+ D +L+EE+TRY F LQVKQD+ QGRL C
Sbjct: 74 AKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVN 133
Query: 155 SAALLISHIVQSEIGDFDEALDRE-HLAKNKYIP-QQDALEDKIVEFHHNHIGQTPAESD 212
+AA L ++ +QSE+GD+D ++++ +++P Q++ LE+ I H +GQ P+E++
Sbjct: 134 TAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEAE 193
Query: 213 FQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFK 272
L A+ LEMYG+ LHP ++ L + G++V++ ++ + W ++ K+ FK
Sbjct: 194 LNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFK 253
Query: 273 RKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFS 332
+F +LR + + F S+ CK WK VEHH FFR+ E L
Sbjct: 254 ETQF--ELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSK 311
Query: 333 RGS---SFRFSGRTQKQV-LDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNS 383
GS R+SGRT Q+ D + R SK + R +QP E NS
Sbjct: 312 FGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQPAESNS 366
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 165 bits (418), Expect = 2e-40
Identities = 152/638 (23%), Positives = 278/638 (43%), Gaps = 80/638 (12%)
Query: 451 EEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQAS 510
+ +V ++ P P+T S G+ S G V P ++
Sbjct: 124 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEER-GAETETKVQERE 182
Query: 511 PLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTV 570
SPL +Q + K K + IA E+ TER Y+ L+++ F +
Sbjct: 183 NGESPLELEQL------DQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKL 236
Query: 571 SKE---DAMPEALKSLIFPNFEPLHKFHTNFL-KEIEQRLALWEGRSNAQIRDYQRIGDV 626
+E + P + + IF N ++ FH+ FL E+E+R+ WE RIGD+
Sbjct: 237 LEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTP--------RIGDI 288
Query: 627 MLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVC-YLPLNTFLLRP 685
+ K +K ++ A+E ++N + + ++ + + QK+C L L +L P
Sbjct: 289 LQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEP 348
Query: 686 LHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKK 745
+ R+ Y+ +L+ + PP D+ D + +L I+ + + + KMEN +KL E+ +
Sbjct: 349 VQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYE 408
Query: 746 DLIGIDNLVVPGREFIRLGSLSKLSGK--GLQQRMFFLFNDVLLY-TSRGLTASNQFKVH 802
L +++V P E I+ G + KL+ + Q+R FLFN++LLY + ++F V
Sbjct: 409 MLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVR 468
Query: 803 GQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSS 862
++ + GM I E+++E PH + G+ +++ + ASS + E+W++ +Q ID +
Sbjct: 469 TRVGIDGMKIVETQNE-EYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRH 527
Query: 863 SPAPEFLASSPPDNKSPDEATAAD---------QESEDDL----SASRTSLERQAPHRGN 909
+A DN E + A+ +++E + +L R+ H
Sbjct: 528 ETFRNAIAK---DNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRA 584
Query: 910 TMVHVCWHRNTSVSMVDFS-----------------------------IAVEN-QLSGN- 938
VCW + + +++ + +E+ ++SGN
Sbjct: 585 CGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNS 644
Query: 939 ----LLRKFKNSNGWQKLWVVFTN---FCLFFYKSHQDNHPLASLPLLGYSLTIPSESEN 991
L+ + S WQK W V L+ Y + QD A++PLLGY + S +
Sbjct: 645 VVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSAD 704
Query: 992 IQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATS 1029
+ + FKL V+ F A+SE ++W++VI A +
Sbjct: 705 L--PHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVT 740
>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
Length = 1430
Score = 157 bits (397), Expect = 5e-38
Identities = 115/397 (28%), Positives = 202/397 (50%), Gaps = 36/397 (9%)
Query: 527 DEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSK------EDAMPEAL 580
DED G + K + IAKE+ ++E+ ++ L+++ F+ V+ + + + +
Sbjct: 863 DEDNGMKS-----KVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRI 917
Query: 581 KSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAH 640
+ I L++ + + LKE+E+R+ W + QRI D+ +K +K + +
Sbjct: 918 LNQILYYLPQLYELNRDLLKELEERMLHW--------TEQQRIADIFVKKGPYLKMYSTY 969
Query: 641 LWKHSEALEALENGIKSSRRLENFCRDFELQKVC-YLPLNTFLLRPLHRLMHYKQVLERL 699
+ + + + L+ K + R+FE+ C L L +LL+P+ R+ Y+ +L
Sbjct: 970 IKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDY 1029
Query: 700 CKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGRE 759
K+ D+RD + ALA + E+ + TM + +NFQKL +++ L G +V PGR
Sbjct: 1030 LKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRV 1089
Query: 760 FIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEW 819
F++ G L KLS K +Q RMFFLFND LLYT+ S +K++ L L GM + + E
Sbjct: 1090 FLKEGILMKLSRKVMQPRMFFLFNDALLYTTP--VQSGMYKLNNMLSLAGMKVRKPTQE- 1146
Query: 820 GVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAI-DLAEKSSSPAPEFLASSPPDNKS 878
+ L + +S I++ASS +E ++W+E I AI + A+K + P ++S
Sbjct: 1147 AYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCP---------SRS 1197
Query: 879 PDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVC 915
DE AD E+++++S + P TM +C
Sbjct: 1198 LDE---ADSENKEEVSPLGSKAPIWIPDTRATMCMIC 1231
Score = 57.4 bits (137), Expect = 7e-08
Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 1/97 (1%)
Query: 932 ENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESEN 991
++ +SG L R N W+ W V N L+ Y + +D L S PLLG+++ I + EN
Sbjct: 1333 DSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTV-IQVKDEN 1391
Query: 992 IQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSAT 1028
+ LH Y F+AE ++ ++W+E + T
Sbjct: 1392 SESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGT 1428
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 142 bits (358), Expect = 2e-33
Identities = 162/701 (23%), Positives = 274/701 (39%), Gaps = 101/701 (14%)
Query: 415 PKVSAGEPGSHPSPAPRRSPAGNKQADGAAS------APTEEEEEVVKDRTQQ----SKP 464
P S G P P P P + +G AS AP + E V +R S P
Sbjct: 232 PGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSP 291
Query: 465 QPPQ----------PSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLIS 514
+ PS G P L+ + V +A + S + D ++
Sbjct: 292 SNSEETCFVSDDGPPSHSLCPGPPALASVPV----ALADPHRPGSQEVDSDLEEEDDEEE 347
Query: 515 PLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKE- 573
D+ P E + + K + IA E+ TE+ Y+ L ++ F + + +E
Sbjct: 348 EEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEA 407
Query: 574 ---DAMPEALKSLIFPNFEPLHKFHTNFL-KEIEQRLALWEGRSNAQIRDYQRIGDVMLK 629
+ P + IF N ++ FH FL E+E+R+ W+ Y RIGD++ K
Sbjct: 408 RNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDR--------YPRIGDILQK 459
Query: 630 NIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVC-YLPLNTFLLRPLHR 688
+K ++ A+E + + S + + + + ++ C L L +L P+ R
Sbjct: 460 LAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQR 519
Query: 689 LMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLI 748
+ Y+ +L+ P D +D + +L I + + KME KL ++ + L
Sbjct: 520 IPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLG 579
Query: 749 GIDNLVVPGREFIRLGSLSKLSGKG--LQQRMFFLFNDVLLYTSRGLTASNQ-FKVHGQL 805
G +++V P +E I+ G + KLS K Q R LFND LLY L Q F V ++
Sbjct: 580 GEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARI 639
Query: 806 PLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPA 865
+ GM ++ES + +P + G+++S+ + A + E + WV+ I + E++
Sbjct: 640 DVDGMELKESSN-LNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETF 698
Query: 866 PEFLASSPPDNKSPDEATAAD--------------------QESEDDLS----------- 894
+++ D +P + D QE + ++
Sbjct: 699 KLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGH 758
Query: 895 ---------ASRTSLERQAPHRGNTMVHVCWH---------------RNTSVSMVDFSIA 930
+R + +R T +V H R S+ S+A
Sbjct: 759 VVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVA 818
Query: 931 VENQLSGNLLRKF-KNSNGWQKLWVVFTN---FCLFFYKSHQDNHPLASLPLLGYSLTIP 986
EN + + L K GW K W V L+ Y + QD SLPL+G+ + P
Sbjct: 819 AENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPP 878
Query: 987 SESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSA 1027
E + +VFK+ +YF E+E RWM V+ A
Sbjct: 879 EAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRA 919
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 139 bits (349), Expect = 2e-32
Identities = 99/378 (26%), Positives = 190/378 (50%), Gaps = 25/378 (6%)
Query: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
K +S+++ +D E F + GK L D V + L E +FGL++ D K + WL L
Sbjct: 3 KTISVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
Query: 98 LKPIVKQ-IRRPKHVVVKFVVKFFPPDHTQ-LQEELTRYLFALQVKQDLAQGRLTCNDTS 155
K + Q +R+ ++ KF KF+P D ++ L +++T+ LF LQVK+ + + C +
Sbjct: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
Query: 156 AALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQ---------DALEDKIVEFHHNHIG 205
A LL S+ VQS+ GDF++ + + +LA +K +PQ+ D E++I +H H G
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
Query: 206 QTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKIN---AFN 262
++ + L+IA+ LEMYG+ K+++G+++ L V G+ +++ ++ F
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
Query: 263 WAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEP 322
W+++R +SF K+F+IK P A F K +C+ +H + +P
Sbjct: 242 WSEIRNISFNDKKFVIK--PIDKKA--PDFVFYAPRLRINKRILALCMGNHELYMRRRKP 297
Query: 323 KPKPKPVLFSRGSSFRFSGRTQKQVLDYVKE----GGHKKVQFER-KHSKIHSIRSLASQ 377
+ ++ + + ++ +L+ K+ +K + ER K + ++ + Q
Sbjct: 298 DTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQ 357
Query: 378 PTELNSEVLEQSQQSTSL 395
+ E+ EQ++++ L
Sbjct: 358 TKKAQQELEEQTRRALEL 375
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 136 bits (343), Expect = 9e-32
Identities = 98/378 (25%), Positives = 189/378 (50%), Gaps = 25/378 (6%)
Query: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
K +++++ +D E F + GK L D V + L E +FGL++ D K + WL L
Sbjct: 3 KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
Query: 98 LKPIVKQ-IRRPKHVVVKFVVKFFPPDHTQ-LQEELTRYLFALQVKQDLAQGRLTCNDTS 155
K + +Q +++ + KF KFFP D ++ L +E+T+ LF LQVK+ + + C +
Sbjct: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
Query: 156 AALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQ---------DALEDKIVEFHHNHIG 205
A LL S+ VQ++ GD+++ + + +LA ++ +PQ+ + E++I +H H G
Sbjct: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
Query: 206 QTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKIN---AFN 262
+S + L+IA+ LEMYG+ K+++GT++ L V G+ +++ K+ F
Sbjct: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
Query: 263 WAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEP 322
W+++R +SF K+F+IK P A F K +C+ +H + +P
Sbjct: 242 WSEIRNISFNDKKFVIK--PIDKKA--PDFVFYAPRLRINKRILALCMGNHELYMRRRKP 297
Query: 323 KPKPKPVLFSRGSSFRFSGRTQKQVLDYVKE----GGHKKVQFER-KHSKIHSIRSLASQ 377
+ ++ + + ++ L+ K+ +K + ER K + ++ + Q
Sbjct: 298 DTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQ 357
Query: 378 PTELNSEVLEQSQQSTSL 395
+ E+ EQ++++ L
Sbjct: 358 TIKAQKELEEQTRKALEL 375
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 134 bits (338), Expect = 3e-31
Identities = 84/286 (29%), Positives = 145/286 (50%), Gaps = 15/286 (5%)
Query: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102
+IQ+L++ F + + G+ L+AV L L E YF L + + + W+DL KP+
Sbjct: 26 RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLK 85
Query: 103 KQIRR-PKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLIS 161
KQ+ + V F V F+ P +QLQ+E+TRY + LQ+K+D+ +G + C A L
Sbjct: 86 KQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAG 145
Query: 162 HIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVE--------FHHNHIGQTPAESDF 213
VQ++ GDFD+ ++ L K P ++K++E H + G T +++
Sbjct: 146 LAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEM 205
Query: 214 QLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILV-FQGFTKINAFNWAKVRKLSFK 272
++ R++ YG +PAKD +G+ I++ GI V + F W + +S
Sbjct: 206 LYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHN 265
Query: 273 RKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRL 318
+ F ++L AN ++T++F + K W++CV H F+RL
Sbjct: 266 KSFFALEL---ANK--EETIQFQTEDMETAKYIWRLCVARHKFYRL 306
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 132 bits (331), Expect = 2e-30
Identities = 98/378 (25%), Positives = 181/378 (47%), Gaps = 25/378 (6%)
Query: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
K +++++ +D E F + GK L D V + L E YFGL + D+K WL L
Sbjct: 3 KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
Query: 98 LKPI-VKQIRRPKHVVVKFVVKFFPPDHTQ-LQEELTRYLFALQVKQDLAQGRLTCNDTS 155
K + +++R+ + KF KF+P D + L +++T+ LF LQVK+ + + C +
Sbjct: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
Query: 156 AALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQ---------DALEDKIVEFHHNHIG 205
A LL S+ VQ++ GD+++ + + +L+ + IPQ+ D ED+I +H H G
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
Query: 206 QTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKIN---AFN 262
+ + L+IA+ LEMYGI K+++GT + L V G+ +++ K+ F
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
Query: 263 WAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEP 322
W+++R +SF K+F+IK P A F K ++C+ +H + +P
Sbjct: 242 WSEIRNISFNDKKFVIK--PIDKKA--PDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297
Query: 323 KPKPKPVLFSRGSSFRFSGRTQKQVLDYVKE-----GGHKKVQFERKHSKIHSIRSLASQ 377
+ ++ + + ++Q L+ K+ K+ K + ++ +
Sbjct: 298 DTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEK 357
Query: 378 PTELNSEVLEQSQQSTSL 395
+ E+ EQ Q++ L
Sbjct: 358 TKKAERELSEQIQRALQL 375
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 132 bits (331), Expect = 2e-30
Identities = 98/378 (25%), Positives = 181/378 (47%), Gaps = 25/378 (6%)
Query: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
K +++++ +D E F + GK L D V + L E YFGL + D+K WL L
Sbjct: 3 KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
Query: 98 LKPI-VKQIRRPKHVVVKFVVKFFPPDHTQ-LQEELTRYLFALQVKQDLAQGRLTCNDTS 155
K + +++R+ + KF KF+P D + L +++T+ LF LQVK+ + + C +
Sbjct: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
Query: 156 AALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQ---------DALEDKIVEFHHNHIG 205
A LL S+ VQ++ GD+++ + + +L+ + IPQ+ D ED+I +H H G
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
Query: 206 QTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKIN---AFN 262
+ + L+IA+ LEMYGI K+++GT + L V G+ +++ K+ F
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
Query: 263 WAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEP 322
W+++R +SF K+F+IK P A F K ++C+ +H + +P
Sbjct: 242 WSEIRNISFNDKKFVIK--PIDKKA--PDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297
Query: 323 KPKPKPVLFSRGSSFRFSGRTQKQVLDYVKE-----GGHKKVQFERKHSKIHSIRSLASQ 377
+ ++ + + ++Q L+ K+ K+ K + ++ +
Sbjct: 298 DTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEK 357
Query: 378 PTELNSEVLEQSQQSTSL 395
+ E+ EQ Q++ L
Sbjct: 358 TKKAERELSEQIQRALQL 375
>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
Length = 1462
Score = 127 bits (319), Expect = 5e-29
Identities = 148/611 (24%), Positives = 250/611 (40%), Gaps = 71/611 (11%)
Query: 265 KVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKP 324
K +K SFKR L + N + D + +SR +S +H R+ E +
Sbjct: 647 KKKKSSFKRFLALTFKKKTENKLHVDVN--VSSSRSSSES------SYHGPSRILEVDRR 698
Query: 325 K--PKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELN 382
P L SR R S + + ++G K V F R S++ S + P
Sbjct: 699 SLSNSPQLKSRTGKLRASESPSSLI--FYRDGKRKGVPFSRTVSRVESFEDRSRPPF--- 753
Query: 383 SEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAG-EPGSHPSPAPRRSPAGNKQ-A 440
LT P + P +++ E P P R+ A K
Sbjct: 754 --------LPLPLTKPRSISFPSADTSDYENIPAMNSDYENIQIPPRRPARAGAFTKLFE 805
Query: 441 DGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSP 500
D + + T E + D + + + Q S S + V AP
Sbjct: 806 DQSRALSTANENDGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPISSAAPKE----- 860
Query: 501 NLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDK------AYFIAKEVSTTERT 554
+L+ D +Q S +++ED R T K A IA+E+ ++E+
Sbjct: 861 DLTSDEEQRS--------------SEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKA 906
Query: 555 YLKDLEVITSWFQSTVSK--EDAMPEALKSLI-------FPNFEPLHKFHTNFLKEIEQR 605
Y++ L+ + F V + +D E +L +H H L+E+E+R
Sbjct: 907 YVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEER 966
Query: 606 LALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFC 665
L+ WE + Q++ DV L QG H A H+ + L L S RL
Sbjct: 967 LSNWESQ--------QKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAV 1018
Query: 666 RDFELQ-KVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMV 724
R+FE + LLR + RL Y+ +L + P A++ + + AL+ I+++
Sbjct: 1019 REFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVT 1078
Query: 725 AQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFND 784
+ + +M + EN QKL ++ + G +L+ PGREF++ G+L K++GK + R FL ND
Sbjct: 1079 DRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMND 1138
Query: 785 VLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEM 844
VLLYT ++++ L + M + E VP+ L + ++++ASS +E
Sbjct: 1139 VLLYTYP--QKDGKYRLKNTLAVANMKVSRPVME-KVPYALKIETSESCLMLSASSCAER 1195
Query: 845 EKWVEDIQMAI 855
++W + A+
Sbjct: 1196 DEWYGCLSRAL 1206
Score = 60.1 bits (144), Expect = 1e-08
Identities = 30/95 (31%), Positives = 52/95 (54%), Gaps = 1/95 (1%)
Query: 935 LSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQK 994
+SG L R + W+KLW V L+ Y + +D L S+PLLG+++ E + +
Sbjct: 1366 ISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEV 1425
Query: 995 DYVFKLHFKSHVYY-FRAESEYTFERWMEVIRSAT 1028
+F L+ K ++Y F+AE + +RW+E + A+
Sbjct: 1426 GPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,919,419
Number of Sequences: 37866
Number of extensions: 2138814
Number of successful extensions: 12444
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 439
Number of HSP's that attempted gapping in prelim test: 11035
Number of HSP's gapped (non-prelim): 1596
length of query: 1045
length of database: 18,247,518
effective HSP length: 113
effective length of query: 932
effective length of database: 13,968,660
effective search space: 13018791120
effective search space used: 13018791120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.