Search of human proteins with 47458820

Search of human proteins with 47458820

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47458820 signal transducer and activator of transcription 3
isoform 3 [Homo sapiens]
         (722 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47458820 signal transducer and activator of transcription 3 i...  1459   0.0  
gi|21618340 signal transducer and activator of transcription 3 i...  1443   0.0  
gi|21618338 signal transducer and activator of transcription 3 i...  1437   0.0  
gi|6274552 signal transducer and activator of transcription 1 is...   775   0.0  
gi|21536301 signal transducer and activator of transcription 1 i...   775   0.0  
gi|4507255 signal transducer and activator of transcription 4 [H...   692   0.0  
gi|4885615 signal transducer and activator of transcription 2 [H...   493   e-139
gi|21618344 signal transducer and activator of transcription 5B ...   316   5e-86
gi|21618342 signal transducer and activator of transcription 5A ...   313   5e-85
gi|23397678 signal transducer and activator of transcription 6 [...   191   2e-48
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         45   2e-04
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    45   3e-04
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    43   0.001
gi|71061468 centromere protein E [Homo sapiens]                        42   0.002
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     42   0.002
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             40   0.010
gi|29294627 PTPRF interacting protein binding protein 1 isoform ...    40   0.010
gi|33188443 microfilament and actin filament cross-linker protei...    39   0.013
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           39   0.013
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                39   0.013
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi...    39   0.017
gi|221219020 NYD-SP11 protein [Homo sapiens]                           39   0.022
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         39   0.022
gi|112734867 retinitis pigmentosa GTPase regulator interacting p...    39   0.022
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    39   0.022
gi|157266264 pleckstrin homology-like domain, family B, member 3...    39   0.022
gi|124249396 coiled-coil domain containing 30 [Homo sapiens]           38   0.029
gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens]              38   0.029
gi|33188445 microfilament and actin filament cross-linker protei...    38   0.029
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    38   0.029

>gi|47458820 signal transducer and activator of transcription 3
           isoform 3 [Homo sapiens]
          Length = 722

 Score = 1459 bits (3776), Expect = 0.0
 Identities = 722/722 (100%), Positives = 722/722 (100%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
           MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60

Query: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
           LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
Sbjct: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120

Query: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
           TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180

Query: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
           SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240

Query: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
           ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300

Query: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
           HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360

Query: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
           QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420

Query: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
           GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480

Query: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
           NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540

Query: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
           GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600

Query: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660
           KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660

Query: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPFIDAV 720
           DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPFIDAV
Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPFIDAV 720

Query: 721 WK 722
           WK
Sbjct: 721 WK 722


>gi|21618340 signal transducer and activator of transcription 3
           isoform 1 [Homo sapiens]
          Length = 770

 Score = 1443 bits (3736), Expect = 0.0
 Identities = 715/715 (100%), Positives = 715/715 (100%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
           MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60

Query: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
           LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
Sbjct: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120

Query: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
           TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180

Query: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
           SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240

Query: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
           ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300

Query: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
           HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360

Query: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
           QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420

Query: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
           GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480

Query: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
           NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540

Query: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
           GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600

Query: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660
           KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660

Query: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTP 715
           DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTP
Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTP 715


>gi|21618338 signal transducer and activator of transcription 3
           isoform 2 [Homo sapiens]
          Length = 769

 Score = 1437 bits (3720), Expect = 0.0
 Identities = 714/715 (99%), Positives = 714/715 (99%), Gaps = 1/715 (0%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
           MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60

Query: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
           LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
Sbjct: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120

Query: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
           TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180

Query: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
           SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240

Query: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
           ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300

Query: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
           HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360

Query: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
           QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420

Query: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
           GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480

Query: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
           NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540

Query: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
           GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600

Query: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660
           KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660

Query: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTP 715
           DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPG AAPYLKTKFICVTP
Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPG-AAPYLKTKFICVTP 714


>gi|6274552 signal transducer and activator of transcription 1
           isoform alpha [Homo sapiens]
          Length = 750

 Score =  775 bits (2001), Expect = 0.0
 Identities = 384/717 (53%), Positives = 526/717 (73%), Gaps = 10/717 (1%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
           M+QW +LQQLD+++LEQ+HQLY DSFPME+RQ+LA W+E QDW +AA+  S AT+ FH+L
Sbjct: 1   MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60

Query: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
           L ++D QYSRF  E+N L QHN+R+ K+ LQ  + E P++++ I+  CL EE ++L+ A 
Sbjct: 61  LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120

Query: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
              Q   Q+ +  + V+ +KQ+ L+  +++V+ +V  +E ++K +E+LQD++DF  KTL+
Sbjct: 121 RFNQ--AQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQ 178

Query: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
           ++    + NG  +S  +Q+   L++M   LD  R+ +V ++  LL+  E  Q  L ++EL
Sbjct: 179 NRE--HETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDEL 236

Query: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
            +WKRRQQ ACIGGPPN CLD+L+NW T +AES  Q RQQ+KKLEEL+QK +Y+ DPI +
Sbjct: 237 VEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITK 296

Query: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
           ++ +L +R   LF+ L++S+FVVERQPCMP HP RPLV+KTGVQFT K+RLLVK  ELNY
Sbjct: 297 NKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNY 356

Query: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
            LK+KV  DKD  +   ++G RKFNILGT+TKVMNMEES NGSL+AEF+HL L+EQ+  N
Sbjct: 357 NLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQK--N 414

Query: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
            G    +  LIVTEELH ++FET++   GL IDLET SLPVVVISN+ Q+P+ WASILWY
Sbjct: 415 AGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWY 474

Query: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
           NML   P+N++FF  PP   W Q++EVLSWQFSS TKRGL+++QL  L EKLLGP  +  
Sbjct: 475 NMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPD 534

Query: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
           G  I W +FCKEN+  K F FW+W+++I++L+KK++L LWN+G IMGFISKERERA+L  
Sbjct: 535 GL-IPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKD 593

Query: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDIS-GKTQIQSVEPYTKQQLNNMSFAEIIMGYKI 659
           + PGTFLLRFSESS+EG +TFTWVE+  + G+    +VEPYTK++L+ ++F +II  YK+
Sbjct: 594 QQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKV 653

Query: 660 MDATNILVSPLVYLYPDIPKEEAFGK-YCRP-ESQEHPEADPGSAAPYLKTKFICVT 714
           M A NI  +PL YLYP+I K+ AFGK Y RP E+ E  E D      Y+KT+ I V+
Sbjct: 654 MAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVS 710


>gi|21536301 signal transducer and activator of transcription 1
           isoform beta [Homo sapiens]
          Length = 712

 Score =  775 bits (2001), Expect = 0.0
 Identities = 384/717 (53%), Positives = 526/717 (73%), Gaps = 10/717 (1%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
           M+QW +LQQLD+++LEQ+HQLY DSFPME+RQ+LA W+E QDW +AA+  S AT+ FH+L
Sbjct: 1   MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60

Query: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
           L ++D QYSRF  E+N L QHN+R+ K+ LQ  + E P++++ I+  CL EE ++L+ A 
Sbjct: 61  LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120

Query: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
              Q   Q+ +  + V+ +KQ+ L+  +++V+ +V  +E ++K +E+LQD++DF  KTL+
Sbjct: 121 RFNQ--AQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQ 178

Query: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
           ++    + NG  +S  +Q+   L++M   LD  R+ +V ++  LL+  E  Q  L ++EL
Sbjct: 179 NRE--HETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDEL 236

Query: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
            +WKRRQQ ACIGGPPN CLD+L+NW T +AES  Q RQQ+KKLEEL+QK +Y+ DPI +
Sbjct: 237 VEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITK 296

Query: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
           ++ +L +R   LF+ L++S+FVVERQPCMP HP RPLV+KTGVQFT K+RLLVK  ELNY
Sbjct: 297 NKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNY 356

Query: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
            LK+KV  DKD  +   ++G RKFNILGT+TKVMNMEES NGSL+AEF+HL L+EQ+  N
Sbjct: 357 NLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQK--N 414

Query: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
            G    +  LIVTEELH ++FET++   GL IDLET SLPVVVISN+ Q+P+ WASILWY
Sbjct: 415 AGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWY 474

Query: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
           NML   P+N++FF  PP   W Q++EVLSWQFSS TKRGL+++QL  L EKLLGP  +  
Sbjct: 475 NMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPD 534

Query: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
           G  I W +FCKEN+  K F FW+W+++I++L+KK++L LWN+G IMGFISKERERA+L  
Sbjct: 535 GL-IPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKD 593

Query: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDIS-GKTQIQSVEPYTKQQLNNMSFAEIIMGYKI 659
           + PGTFLLRFSESS+EG +TFTWVE+  + G+    +VEPYTK++L+ ++F +II  YK+
Sbjct: 594 QQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKV 653

Query: 660 MDATNILVSPLVYLYPDIPKEEAFGK-YCRP-ESQEHPEADPGSAAPYLKTKFICVT 714
           M A NI  +PL YLYP+I K+ AFGK Y RP E+ E  E D      Y+KT+ I V+
Sbjct: 654 MAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVS 710


>gi|4507255 signal transducer and activator of transcription 4 [Homo
           sapiens]
          Length = 748

 Score =  692 bits (1787), Expect = 0.0
 Identities = 350/714 (49%), Positives = 494/714 (69%), Gaps = 12/714 (1%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
           M+QWNQ+QQL+ ++LEQ+ Q Y D+FPME+R  LA WIE+QDW  A++ E+ AT++  NL
Sbjct: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60

Query: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
           L ++D+Q  R  +E N+L  HNL+RI++ LQ ++   PM +A +++ CL EE R+L  AA
Sbjct: 61  LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL-AAA 119

Query: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
               QG       ++ V+E+Q+ +E  +  ++  VQ  EQ  K +E+LQD+FD+ YKT++
Sbjct: 120 NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQ 179

Query: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
           +     D +  N ++  Q++  L++ML +LD  R+  +S++  ++   + +  T+  EEL
Sbjct: 180 TM----DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235

Query: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
            DWKRRQQIACIGGP +  LD+L+N  T LAES  Q R+Q++KLEE   K++Y+GDPI  
Sbjct: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295

Query: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
            R  + ER+  L  NL K++FVVERQPCMP HP RPLV+KT +QFT K+RLL+K PELNY
Sbjct: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355

Query: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
           Q+K+K  IDK+   ++    +R+F + GTN K M++EES+NGSLS EF+HL  +E +   
Sbjct: 356 QVKVKASIDKNVSTLS----NRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSA 411

Query: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
           GG+ N +   +VTEELH ITFET++   GL IDLET SLPVV+ISN+ Q+PNAWASI+WY
Sbjct: 412 GGKGN-EGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWY 470

Query: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
           N+ TN+ +N+ FF  PP  T  Q+ EV+SWQFSS   RGL+ +QL  LAEKL     +YS
Sbjct: 471 NVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQS-SYS 529

Query: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
              +TWAKFCKE++ GK F+FW WL+ I+DL+KK+IL LW +GY+MGF+SKE+ER +L  
Sbjct: 530 DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKD 589

Query: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660
           K PGTFLLRFSES   GG+TFTWV+   SG+ +  SVEPY K +L+ + FA+I+  YK++
Sbjct: 590 KMPGTFLLRFSESHL-GGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVI 648

Query: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVT 714
            A NI  +PL YLYPDIPK++AFGK+   +  E           Y+ + FI ++
Sbjct: 649 MAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPIS 702


>gi|4885615 signal transducer and activator of transcription 2 [Homo
           sapiens]
          Length = 851

 Score =  493 bits (1270), Expect = e-139
 Identities = 279/690 (40%), Positives = 418/690 (60%), Gaps = 17/690 (2%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSF-PMELRQFLAPWIESQDWAYAA--SKESHATLVF 57
           MAQW  LQ LD+ + +QLHQLYS S  P+++RQ+LA WIE Q+W  AA  S +S AT++F
Sbjct: 1   MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLF 60

Query: 58  HNLLGEIDQQYSRFLQE-SNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLL 116
            + L +++ +  R  Q+  ++L QHNLR+  + +Q  + + P ++A ++   L EE R+L
Sbjct: 61  FHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQP-FSQDPTQLAEMIFNLLLEEKRIL 119

Query: 117 QTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176
             A  A  + G+    T   V  +Q  +E  + D+R  ++ L + +  +++ QD F F Y
Sbjct: 120 IQAQRAQLEQGEPVLETP--VESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRY 177

Query: 177 KTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLT 236
           K ++++G    L+ +      QK+  L++ L  LD+ R+ ++     LL  +  + + L 
Sbjct: 178 K-IQAKGKTPSLDPHQTK--EQKI--LQETLNELDKRRKEVLDASKALLGRLTTLIELLL 232

Query: 237 DEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGD 296
            + L +WK +QQ ACI  P +  L++LE W T+ A+     RQ +K+L+ L   VSY+ D
Sbjct: 233 PK-LEEWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDD 291

Query: 297 PIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFP 356
           P+ +   +   ++ EL + L+  AFVVE QPCMP  P RPL++KTG +FT + RLLV+  
Sbjct: 292 PLTKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQ 351

Query: 357 ELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQ 416
           E N  L ++V ID++      L+G RKFNIL +N K +  E+  +  L  +F +LTL EQ
Sbjct: 352 EGNESLTVEVSIDRNPPQ---LQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQ 408

Query: 417 RCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWAS 476
           R G  G+ +    L VTEELH+I+F  +  +QGLK +L+T +LPVV+ISN+ Q+  AWAS
Sbjct: 409 RSGGSGKGSNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWAS 468

Query: 477 ILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPG 536
           +LW+N+L+ N +N  FF+ PP   W  +   LSWQFSS   RGL+ +QL+ L  KL G  
Sbjct: 469 VLWFNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQN 528

Query: 537 VNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERA 596
                  ++WA F K         FW WLD I++LV  ++  LWN+G IMGF+S+ +ER 
Sbjct: 529 CRTEDPLLSWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERR 588

Query: 597 ILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMG 656
           +L     GTFLLRFSESS EGG+T +WVE     K  I SV+PYTK+ L ++   EII  
Sbjct: 589 LLKKTMSGTFLLRFSESS-EGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRH 647

Query: 657 YKIMDATNILVSPLVYLYPDIPKEEAFGKY 686
           Y+++   NI  +PL +LYP IP++EAFG Y
Sbjct: 648 YQLLTEENIPENPLRFLYPRIPRDEAFGCY 677


>gi|21618344 signal transducer and activator of transcription 5B
           [Homo sapiens]
          Length = 787

 Score =  316 bits (809), Expect = 5e-86
 Identities = 234/751 (31%), Positives = 380/751 (50%), Gaps = 69/751 (9%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYA----ASKESHATLV 56
           MA W Q QQL    L Q+  LY   FP+E+R +L+ WIESQ W         +   AT +
Sbjct: 1   MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL 60

Query: 57  FHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLL 116
              L+ E+ ++    + E   L +  L      LQ+ Y   PME+ R +   L+ E RL+
Sbjct: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120

Query: 117 QTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176
           + A   +   G      A  +++K   + Q  +++R   QD E ++K ++  Q+ F   Y
Sbjct: 121 REANNGSSPAGSL----ADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQY 176

Query: 177 K-TLKSQ---GDMQDLNG----NNQSVTRQKMQQLEQMLT----ALDQMRRSIVSELAGL 224
           + +L+ Q   G +  L+     + ++  +QK   LE  L      L Q R  +  +    
Sbjct: 177 QESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKT 236

Query: 225 LSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL 284
           L  +   Q  + D+EL  WKRRQQ+A  GGPP   LD L++W   LAE   Q RQQI++ 
Sbjct: 237 LQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRA 296

Query: 285 EELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ 344
           E L Q++   G P+ +    +   I ++   L+ S F++E+QP        P V+KT  +
Sbjct: 297 EHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTK 347

Query: 345 FTTKVRLLVKFPELNYQL---KIKVCIDKDSGDVAALRGSRKFNILG----TNTKVMNME 397
           F   VRLLV   +LN  +   ++K  I  +    + L+     N        N  VM   
Sbjct: 348 FAATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYH 406

Query: 398 ESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQG--LKIDLE 455
           ++  G+LSA F++++L+  +     R++   +  VTEE   I FE++    G  L   ++
Sbjct: 407 QAT-GTLSAHFRNMSLKRIK-----RSDRRGAESVTEEKFTILFESQFSVGGNELVFQVK 460

Query: 456 THSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST 515
           T SLPVVVI +  Q  NA A++LW N     P  V F     +  W Q+ E L+ +F + 
Sbjct: 461 TLSLPVVVIVHGSQDNNATATVLWDNAFAE-PGRVPFAVPDKV-LWPQLCEALNMKFKAE 518

Query: 516 TK--RGLSIEQLTTLAEKLLGPGVN----YSGCQITWAKFCKENMAGKGFSFWVWLDNII 569
            +  RGL+ E L  LA+KL     +    YSG  ++W++F +EN+ G+ ++FW W D ++
Sbjct: 519 VQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVM 578

Query: 570 DLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDIS 629
           +++KK++   WN+G I+GF++K++   +L  KP GTFLLRFS+ S+ GG+T  W  K  S
Sbjct: 579 EVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAW--KFDS 635

Query: 630 GKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRP 689
            +    ++ P+T +  +  S A+     ++ D     ++ L+Y++PD PK+E + KY  P
Sbjct: 636 QERMFWNLMPFTTRDFSIRSLAD-----RLGD-----LNYLIYVFPDRPKDEVYSKYYTP 685

Query: 690 ESQEHPEADPGSAAPYLKTKFICVTP-FIDA 719
              E   A   +   Y+K +   V P F++A
Sbjct: 686 VPCE--SATAKAVDGYVKPQIKQVVPEFVNA 714


>gi|21618342 signal transducer and activator of transcription 5A
           [Homo sapiens]
          Length = 794

 Score =  313 bits (801), Expect = 5e-85
 Identities = 226/720 (31%), Positives = 362/720 (50%), Gaps = 66/720 (9%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYA----ASKESHATLV 56
           MA W Q QQL    L Q+  LY   FP+E+R +LA WIESQ W           + AT +
Sbjct: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60

Query: 57  FHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLL 116
              L+ E+ ++    + E   L +  L      LQ  Y   P+E+ R +   L+ E RL+
Sbjct: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120

Query: 117 QTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176
           + A   +   G         +++K   + Q  +++R   QD E ++K ++  Q+ F   Y
Sbjct: 121 REANNCSSPAGIL----VDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQY 176

Query: 177 K-TLKSQGDMQDLNG-------NNQSVTRQKMQQLEQMLT----ALDQMRRSIVSELAGL 224
           + +L+ Q     L         + ++  +QK   LE  L      L Q R  +  +    
Sbjct: 177 QESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKT 236

Query: 225 LSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL 284
           L  +   Q  + D+EL  WKRRQQ+A  GGPP   LD L++W   LAE   Q RQQI++ 
Sbjct: 237 LQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRA 296

Query: 285 EELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ 344
           E L Q++   G P+ +    +   I ++   L+ S F++E+QP        P V+KT  +
Sbjct: 297 EHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTK 347

Query: 345 FTTKVRLLVKFPELNYQL---KIKVCIDKDSGDVAALRGSRKFNILG----TNTKVMNME 397
           F   VRLLV   +LN  +   ++K  I  +    + L+     N        N  VM   
Sbjct: 348 FAATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYH 406

Query: 398 ESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETE--VYHQGLKIDLE 455
           ++  G+LSA F++++L+  +     RA+   +  VTEE   + FE++  V    L   ++
Sbjct: 407 QAT-GTLSAHFRNMSLKRIK-----RADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK 460

Query: 456 THSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST 515
           T SLPVVVI +  Q  NA A++LW N     P  V F     +  W Q+ E L+ +F + 
Sbjct: 461 TLSLPVVVIVHGSQDHNATATVLWDNAFAE-PGRVPFAVPDKV-LWPQLCEALNMKFKAE 518

Query: 516 TK--RGLSIEQLTTLAEKLLGPGVN----YSGCQITWAKFCKENMAGKGFSFWVWLDNII 569
            +  RGL+ E L  LA+KL     +    YSG  ++W++F +EN+ G  ++FW W D ++
Sbjct: 519 VQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVM 578

Query: 570 DLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDIS 629
           +++KK+    WN+G I+GF++K++   +L  KP GTFLLRFS+ S+ GG+T  W  K  S
Sbjct: 579 EVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAW--KFDS 635

Query: 630 GKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRP 689
            +  + +++P+T +  +  S A+     ++ D     +S L+Y++PD PK+E F KY  P
Sbjct: 636 PERNLWNLKPFTTRDFSIRSLAD-----RLGD-----LSYLIYVFPDRPKDEVFSKYYTP 685


>gi|23397678 signal transducer and activator of transcription 6
           [Homo sapiens]
          Length = 847

 Score =  191 bits (486), Expect = 2e-48
 Identities = 196/715 (27%), Positives = 327/715 (45%), Gaps = 108/715 (15%)

Query: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
           M+ W  + ++     E++ +LY D FP  LR  L  W+ESQ W +    ++    +   L
Sbjct: 1   MSLWGLVSKMPP---EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56

Query: 61  LGEIDQQYSRFLQES---NVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQ 117
           L +  Q     + E    + + QH        L+S Y   P+++     + L  E + + 
Sbjct: 57  LSDTVQHLQASVGEQGEGSTILQHI-----STLESIYQRDPLKLVATFRQILQGEKKAVM 111

Query: 118 TAATAAQQGGQANH-PTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176
                     Q  H P      +++   +  L+ ++ RV ++     + E LQ   +   
Sbjct: 112 E---------QFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHL---LREALQKGAEAGQ 159

Query: 177 KTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLT 236
            +L S  +    NG   S                 +    ++ E  G L A     K L 
Sbjct: 160 VSLHSLIETP-ANGTGPS-----------------EALAMLLQETTGELEAA----KALV 197

Query: 237 DEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGD 296
            + +  WKR+QQ+A  G P          +  SLA  Q +    +    +LQQ+V   G 
Sbjct: 198 LKRIQIWKRQQQLAGNGAP----------FEESLAPLQERCESLVDIYSQLQQEVGAAGG 247

Query: 297 PIV-QHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKF 355
            +  + R  L  R+ E+ R L+ S F+VE+QP        P V+KT  +F   VR L+  
Sbjct: 248 ELEPKTRASLTGRLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGL 299

Query: 356 PELNYQLK-----IKVCIDKDSGDVAALRG----SRKFNILGTNTKVMNMEESNNGSL-S 405
             L    K       +  +K + +++  +G    +     +  NT  + +E S  G+  S
Sbjct: 300 RFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNT--VPLENSIPGNCCS 357

Query: 406 AEFKHLTLRE-QRCGNGGRANCDASLIVTEELHLITFETEVYHQG---LKIDLETHSLPV 461
           A FK+L L++ +RC   G  +      VTEE   + F    +  G   L I L+  SLP+
Sbjct: 358 ALFKNLLLKKIKRCERKGTES------VTEEKCAVLFSAS-FTLGPGKLPIQLQALSLPL 410

Query: 462 VVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST--TKRG 519
           VVI +  Q  NA A+ILW N  +   + V F     +  W+++ E L+ +F +   T RG
Sbjct: 411 VVIVHGNQDNNAKATILWDNAFSEMDR-VPFVVAERV-PWEKMCETLNLKFMAEVGTNRG 468

Query: 520 LSIEQLTTLAEKLLGPGV----NYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKY 575
           L  E    LA+K+          +    ++W++F KE + G+GF+FW W D ++DL K+ 
Sbjct: 469 LLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRC 528

Query: 576 ILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQ 635
           + + W++  I+GFISK+   ++L  +P GTFLLRFS+ S+ GG+T   V +   G  QI+
Sbjct: 529 LRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSD-SEIGGITIAHVIRGQDGSPQIE 587

Query: 636 SVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPE 690
           +++P++ + L+  S     +G +I D     ++ L  LYP  PK+EAF  + +PE
Sbjct: 588 NIQPFSAKDLSIRS-----LGDRIRD-----LAQLKNLYPKKPKDEAFRSHYKPE 632


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 70/282 (24%), Positives = 118/282 (41%), Gaps = 21/282 (7%)

Query: 9   QLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKE-SHATLVFHNLLGEIDQQ 67
           Q+D R + QL +   D    +LR+F +   + QD     ++E S AT  +     +++++
Sbjct: 308 QMD-RKINQLSEENGD-LSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365

Query: 68  YSRFLQ------ESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAAT 121
            S  LQ      E N + Q  L ++++ L       P E   ++   L  E+ L Q AAT
Sbjct: 366 LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLET-LKQEAAT 424

Query: 122 AAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKS 181
            A    Q       + TE+ Q   + L +     ++ +Q   ++ +LQ     N    K 
Sbjct: 425 LAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS-NLSQAKE 483

Query: 182 QGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQ----KTLTD 237
           + + Q    +   +T Q +  L   LT L+   +    ELAGL    +  Q    +TL  
Sbjct: 484 ELE-QASQAHGARLTAQ-VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541

Query: 238 EELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQ 279
           +E A    R Q+  +       L + E  +  +AE Q  TRQ
Sbjct: 542 QEQASQGLRHQVEQLSS----SLKQKEQQLKEVAEKQEATRQ 579



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 65/295 (22%), Positives = 123/295 (41%), Gaps = 29/295 (9%)

Query: 5   NQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHN--LLG 62
           N++ Q     LE+      D+ P E  + L   ++ +       K+  ATL  +N  L  
Sbjct: 380 NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE-----TLKQEAATLAANNTQLQA 434

Query: 63  EIDQ-QYSRFLQESNVLYQH-NLRRIKQFLQSRYLEKPMEIARIV-ARCLWEESRLLQTA 119
            ++  +  R  QE+ +L +  +    KQ L S   +    I+ +  A+   E++     A
Sbjct: 435 RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA 494

Query: 120 ATAAQQGGQANHPTAAVVTEKQQ------MLEQHLQDVRKRVQDLEQKMKVVENLQDDFD 173
              AQ     +  T    T +QQ      + +Q  +   +  Q L+Q+ +  + L+   +
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554

Query: 174 FNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQK 233
               +LK +          Q  TRQ   Q  Q+ TA ++ R + + E    L  +E ++K
Sbjct: 555 QLSSSLKQKEQQLKEVAEKQEATRQDHAQ--QLATAAEE-REASLRERDAALKQLEALEK 611

Query: 234 TLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQ 288
                +L   +++ Q+A      N   D  +   TS+ ++Q +  +  +K+EELQ
Sbjct: 612 EKA-AKLEILQQQLQVA------NEARDSAQ---TSVTQAQREKAELSRKVEELQ 656


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 57/271 (21%), Positives = 117/271 (43%), Gaps = 41/271 (15%)

Query: 66   QQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQ 125
            ++Y + L E  V    + +RI+Q  +        EI R+ A      + L          
Sbjct: 1352 EEYRKLLSEKEV----HTKRIQQLTE--------EIGRLKAEIARSNASLTNNQNLIQSL 1399

Query: 126  GGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQD---DFDFNYKTLKSQ 182
                N     V TEK+ + +    D+  ++ D+++K+K +  ++     +   Y+ LK+Q
Sbjct: 1400 KEDLNK----VRTEKETIQK----DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451

Query: 183  GDM-----QDLNGNNQS--VTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTL 235
             D         +G++Q   V+ Q+MQ+L++ L   +   +S+ S+       +E +QKTL
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQ-------VENLQKTL 1504

Query: 236  TDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKG 295
            +++E      ++Q   +       L RL   +      + Q RQQI + EE  +K     
Sbjct: 1505 SEKETEARNLQEQTVQLQSE----LSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560

Query: 296  DPIVQHRPMLEERIVELFRNLMKSAFVVERQ 326
               + H   +++++ +    L +    +++Q
Sbjct: 1561 KSKIAHLAGVKDQLTKENEELKQRNGALDQQ 1591



 Score = 37.0 bits (84), Expect = 0.064
 Identities = 42/183 (22%), Positives = 78/183 (42%), Gaps = 15/183 (8%)

Query: 134 AAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQ 193
           A ++  +++  E+  + V      LEQ MK ++ LQ+D D   K  K    ++  N   +
Sbjct: 434 APILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD---KANKQSSVLERDNRRME 490

Query: 194 SVTRQKMQQLEQMLTALDQMR-----RSIVSELAGLLSAMEYVQKTLTD----EELADWK 244
              +   QQ+  +L  L++ R     R      A + S+ E + + L      EEL    
Sbjct: 491 IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550

Query: 245 RRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYK---GDPIVQH 301
           +R  +A          +  E   + + E QL+    + +LE+L++   ++    D IV+ 
Sbjct: 551 QRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQ 610

Query: 302 RPM 304
           R M
Sbjct: 611 RDM 613



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 34/162 (20%), Positives = 70/162 (43%), Gaps = 24/162 (14%)

Query: 96   EKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRV 155
            E+ +EI R + R    E  + +T    AQ         +    ++ ++LE+ LQ+++  +
Sbjct: 1194 EQILEILRFIRR----EKEIAETRFEVAQV-------ESLRYRQRVELLERELQELQDSL 1242

Query: 156  QDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRR 215
                +K++V        +   K  ++   + + N   +    +  Q L+QM   + ++  
Sbjct: 1243 NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL 1302

Query: 216  SI---------VSELAGLLSAMEYVQKTLTDEELADWKRRQQ 248
             I         +SE +G+L A    +K L +E++  WK R Q
Sbjct: 1303 DILPLQEANAELSEKSGMLQA----EKKLLEEDVKRWKARNQ 1340


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 46/252 (18%), Positives = 114/252 (45%), Gaps = 18/252 (7%)

Query: 100  EIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLE 159
            E+ R   + L E++ L +      +   +A    A +  +KQ+ LE+ L D+  RV++ E
Sbjct: 877  EMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQE-LEEILHDLESRVEEEE 935

Query: 160  QKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSV------TRQKMQQLEQMLTALDQM 213
            ++ ++++N +     + + L+ Q D ++  G  Q +         K++++E+ +  L+  
Sbjct: 936  ERNQILQNEKKKMQAHIQDLEEQLDEEE--GARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993

Query: 214  RRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAES 273
                + E   +   +      L +EE    ++ + +A I     + +  LE  +    + 
Sbjct: 994  NSKFIKEKKLMEDRIAECSSQLAEEE----EKAKNLAKIRNKQEVMISDLEERL----KK 1045

Query: 274  QLQTRQQIKKLE-ELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMH 332
            + +TRQ+++K + +L  + +   D I + +  ++E  ++L +   +    + R     +H
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105

Query: 333  PDRPLVIKTGVQ 344
             +  L +   +Q
Sbjct: 1106 KNNALKVVRELQ 1117



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 35/159 (22%), Positives = 77/159 (48%), Gaps = 7/159 (4%)

Query: 139  EKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQ--GDMQDLNGNNQSVT 196
            + ++ LEQ ++++R ++++LE +++  E+ +   + N + +K+Q   D+Q  +  N+   
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591

Query: 197  RQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRR----QQIACI 252
            R  ++Q+ ++   L+  R+     +A     ME   K L  +  A  K R    +Q+  +
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVAS-KKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650

Query: 253  GGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKV 291
                      LE    S  E   Q+++  KKL+ L+ ++
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 56/256 (21%), Positives = 114/256 (44%), Gaps = 45/256 (17%)

Query: 82   NLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQ 141
            NL+ IK+ L+ ++ +    I   +A+    +S+  Q+         + ++ T  +V+E +
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK-----EKDNETTKIVSEME 1407

Query: 142  QM---------LEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNN 192
            Q          +E  +  + KR+Q+   +MK V   +DD     + L+S+ D   L  N 
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESD--QLKENI 1465

Query: 193  QSVTRQKMQQLEQMLTA--LDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIA 250
            + +  + ++  E++  A    + +   ++EL   LS  E    T+          ++Q+ 
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI----------QKQLE 1515

Query: 251  CIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHR-------P 303
             I        D+L+N I  + E + Q    IK++ E+Q+KV+ +     +HR        
Sbjct: 1516 AIN-------DKLQNKIQEIYEKEEQF--NIKQISEVQEKVN-ELKQFKEHRKAKDSALQ 1565

Query: 304  MLEERIVELFRNLMKS 319
             +E +++EL   L +S
Sbjct: 1566 SIESKMLELTNRLQES 1581



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 62/291 (21%), Positives = 124/291 (42%), Gaps = 38/291 (13%)

Query: 11   DTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSR 70
            + + +++  Q+  D      ++ +A   ESQ+  Y   K + A       + EI+    +
Sbjct: 1594 EMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMT-AVNETQEKMCEIEHLKEQ 1652

Query: 71   FLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQAN 130
            F  E+  L   N+   +    ++ L + +E  R V +   E   L     T   +  Q  
Sbjct: 1653 F--ETQKLNLENIET-ENIRLTQILHENLEEMRSVTK---ERDDLRSVEETLKVERDQLK 1706

Query: 131  HPTAAVVT---EKQQMLE---QHLQDVRKRVQDLE----QKMKVVENLQDDFDFNYKTLK 180
                  +T   EKQ+ L+    HL++ ++ +  L     +K   + N+Q D + +   LK
Sbjct: 1707 ENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALK 1766

Query: 181  SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
            +    QDL    Q   R     L++    +D++ R IVSE    LS M   QK L +   
Sbjct: 1767 A----QDL--KIQEELRIAHMHLKEQQETIDKL-RGIVSEKTDKLSNM---QKDLENSNA 1816

Query: 241  ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKV 291
               ++ Q+           L   E+ + +L +   +T++++ ++E+L++++
Sbjct: 1817 KLQEKIQE-----------LKANEHQLITLKKDVNETQKKVSEMEQLKKQI 1856



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 31/135 (22%), Positives = 66/135 (48%), Gaps = 9/135 (6%)

Query: 109 LWEESRLLQTAATAAQQGGQANHPTAAVVTE---KQQMLEQHLQDVRKRVQDLEQKMKVV 165
           L E  R+ Q     +++  + +    A+ TE   K Q L++  ++V++R+ ++EQ  + +
Sbjct: 837 LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL 896

Query: 166 ENLQDDFDF--NYKTLKSQGDMQDLNGNNQSVTRQK--MQQLEQML-TALDQMRRSIVSE 220
           EN           KTL ++   Q L    +++T++K  ++QL++ L    DQ++  I   
Sbjct: 897 ENRDSTLQTVEREKTLITEKLQQTLE-EVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955

Query: 221 LAGLLSAMEYVQKTL 235
           +   +   E ++  L
Sbjct: 956 VNMNIDTQEQLRNAL 970


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/217 (18%), Positives = 105/217 (48%), Gaps = 17/217 (7%)

Query: 84   RRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQM 143
            +  K    +R LE+ ME    + R   +    ++   ++    G++ H     + + ++ 
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE----LEKSKRA 1529

Query: 144  LEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQ--GDMQDLNGNNQSVTRQKMQ 201
            LEQ +++++ ++++LE +++  E+ +   + N + +K+Q   D+Q  +  ++   +Q ++
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589

Query: 202  QLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL----ADWKRRQ---QIACIGG 254
            Q+ +M   L+  R+    + +  ++A + ++  L D E     A+  R +   Q+  +  
Sbjct: 1590 QVREMEAELEDERK----QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA 1645

Query: 255  PPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKV 291
                C+  L++   S  E   Q ++  KKL+ ++ ++
Sbjct: 1646 QMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM 1682



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 53/274 (19%), Positives = 111/274 (40%), Gaps = 12/274 (4%)

Query: 48   SKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRI-KQFLQSRYLEKPMEIARIVA 106
            SK      +    L E  + +   +QE    +   +  + +Q  Q++ ++  +E A+   
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222

Query: 107  RCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVE 166
                E   L        Q  G + H    V  + Q++  +  +  R R +  ++    V 
Sbjct: 1223 EN--ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK----VT 1276

Query: 167  NLQDDFDFNYKTLKSQGDMQDLNGNNQ-SVTRQKMQQLEQMLTALDQMRRSIVSELAGLL 225
             LQ + D N   L SQ D +        S    ++Q  +++L   ++ + S+ ++L  + 
Sbjct: 1277 KLQVELD-NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335

Query: 226  SAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLE 285
                  ++ L +EE A     +QIA +         ++E+ +  L  ++   R+  K LE
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395

Query: 286  ELQQKVSYK---GDPIVQHRPMLEERIVELFRNL 316
             L Q+   K    D + + +  L++ + +L  +L
Sbjct: 1396 GLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 43/190 (22%), Positives = 81/190 (42%), Gaps = 22/190 (11%)

Query: 132  PTAAVVTEKQQML--EQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLN 189
            P   V  ++++M+  E+ L  VR++    E ++  +E LQ         L+ Q     L 
Sbjct: 836  PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ-----LQ 890

Query: 190  GNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQI 249
               +     + ++L   LTA  Q    I  +L   +   E   + L  E+    +  Q++
Sbjct: 891  AETELCA--EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQEL 948

Query: 250  ACIGGPPNICLDRLENWITSLAESQLQ---TRQQIKKLEELQQKVSYKGDPIVQHRPMLE 306
                       ++LE   ++  + QL+   T  ++KKLEE Q  +  +   + + + +LE
Sbjct: 949  E----------EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998

Query: 307  ERIVELFRNL 316
            +RI E   NL
Sbjct: 999  DRIAEFTTNL 1008


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 53/248 (21%), Positives = 112/248 (45%), Gaps = 25/248 (10%)

Query: 135 AVVTEKQQ---MLEQHLQDVRKRVQDLEQKMKVVE----NLQDDFDFNYKTLKSQGDMQD 187
           A + +KQ+    LE HL++ +++   LEQK + +E     L+ D     K  K Q  +QD
Sbjct: 695 AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD-SLEVKASKEQA-LQD 752

Query: 188 LNGNNQSVTRQKMQQLEQMLTALDQMRRSIVS----ELAGLLSAMEYVQKTLTDEELADW 243
           L    Q  T  +++  E  L+   +M + IVS    +L     A+E +++ LT +E    
Sbjct: 753 LQQQRQLNTDLELRATE--LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810

Query: 244 KRRQQIACIGGPPNI----CLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIV 299
             +Q    +     I      +R++  +T L + +++    + +L  ++ K+S   D + 
Sbjct: 811 ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870

Query: 300 QHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKV-RLLVKFPEL 358
             +   E+          K+A +   + C  +     + ++  ++   ++ + L K  E 
Sbjct: 871 NSKSEFEKE-----NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925

Query: 359 NYQLKIKV 366
           ++QLK+++
Sbjct: 926 SHQLKLEL 933


>gi|29294627 PTPRF interacting protein binding protein 1 isoform 1
           [Homo sapiens]
          Length = 1005

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 46/212 (21%), Positives = 93/212 (43%), Gaps = 19/212 (8%)

Query: 78  LYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVV 137
           +YQ  L R++   +S  L+  +   ++ A+   E+ R L+      ++   A        
Sbjct: 101 VYQERLARLENDKESLVLQVSVLTDQVEAQ--GEKIRDLEFCLEEHREKVNATEEMLQQE 158

Query: 138 TEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTR 197
              +  LE    D+   + +L+ K+  VE  +D  D+  K   ++G +Q++N       R
Sbjct: 159 LLSRTSLETQKLDLMAEISNLKLKLTAVE--KDRLDYEDKFRDTEGLIQEIND-----LR 211

Query: 198 QKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQ--IACIGGP 255
            K+ +++      ++  +S   ELA L   +E        E+ ++ KR Q+  +  + G 
Sbjct: 212 LKVSEMDSERLQYEKKLKSTKDELASLKEQLE--------EKESEVKRLQEKLVCKMKGE 263

Query: 256 PNICLDRLENWITSLAESQLQTRQQIKKLEEL 287
               +DR EN+   L E  ++ ++  K +E L
Sbjct: 264 GVEIVDRDENFKKKLKEKNIEVQKMKKAVESL 295


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 45/243 (18%), Positives = 97/243 (39%), Gaps = 36/243 (14%)

Query: 60   LLGEIDQQYSRFLQESNV---LYQHNLRRIKQFLQSRYLEKPMEIA--RIVARCLWEESR 114
            LL E+ + +   L+++       Q +L++++Q    + L+K       ++   C W    
Sbjct: 2009 LLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSW---- 2064

Query: 115  LLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDF 174
            + Q     A   G+      + + + Q  L+    D++ R       +K +E   ++   
Sbjct: 2065 VGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEE--- 2121

Query: 175  NYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSA--MEYVQ 232
                     +   L+    +  R+K+ Q ++   AL +  R    EL   +++   +  +
Sbjct: 2122 ---------NQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETE 2172

Query: 233  KTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVS 292
            K+   +ELA+ K++             +D L +W+TS+  S  Q    +  +E+L     
Sbjct: 2173 KSKAAKELAENKKK-------------IDALLDWVTSVGSSGGQLLTNLPGMEQLSGASL 2219

Query: 293  YKG 295
             KG
Sbjct: 2220 EKG 2222


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 28/107 (26%), Positives = 50/107 (46%), Gaps = 10/107 (9%)

Query: 111  EESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQD 170
            E   +++   TA  Q  +A H     V ++ + LEQ  +D+ ++   LEQK K +E    
Sbjct: 1375 EHKEVVEPKDTAIYQKDEALHVKNEAVKQQDKALEQKGRDLEQKDTALEQKDKALEPKDK 1434

Query: 171  DFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSI 217
            D +   K L+ +            +  +K + LEQ  TAL+Q  +++
Sbjct: 1435 DLEEKDKALEQK----------DKIPEEKDKALEQKDTALEQKDKAL 1471



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 30/122 (24%), Positives = 54/122 (44%), Gaps = 9/122 (7%)

Query: 111  EESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENL-- 168
            E+ + L+   TA +Q  +A  P    + +K ++LEQ  +   ++ + L+QK++ VE+   
Sbjct: 1452 EKDKALEQKDTALEQKDKALEPKDKDLEQKDRVLEQKEKIPEEKDKALDQKVRSVEHKAP 1511

Query: 169  ------QDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELA 222
                    D D   +T K+             V+ +K Q LEQ   AL Q   ++   + 
Sbjct: 1512 EDTVAEMKDRDLE-QTDKAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKDEALEQNIQ 1570

Query: 223  GL 224
             L
Sbjct: 1571 AL 1572



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 51/208 (24%), Positives = 82/208 (39%), Gaps = 14/208 (6%)

Query: 107  RCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVE 166
            + L ++ R L+   TA +Q  +A  P    + EK + LEQ  +   ++ + LEQK   +E
Sbjct: 1406 KALEQKGRDLEQKDTALEQKDKALEPKDKDLEEKDKALEQKDKIPEEKDKALEQKDTALE 1465

Query: 167  NLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLS 226
                  +   K L+ +            V  QK +  E+   ALDQ  RS V   A   +
Sbjct: 1466 QKDKALEPKDKDLEQK----------DRVLEQKEKIPEEKDKALDQKVRS-VEHKAPEDT 1514

Query: 227  AMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEE 286
              E   + L   + A  ++ Q               LE    +L +      Q I+ LEE
Sbjct: 1515 VAEMKDRDLEQTDKAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKDEALEQNIQALEE 1574

Query: 287  ---LQQKVSYKGDPIVQHRPMLEERIVE 311
                Q++ S   +   +   MLEE+  E
Sbjct: 1575 NHQTQEQESLVQEDKTRKPKMLEEKSPE 1602


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 45/181 (24%), Positives = 81/181 (44%), Gaps = 23/181 (12%)

Query: 72  LQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANH 131
           L+      Q +L ++    +S   +K +++ R+VA+ L EE   LQ     A+Q      
Sbjct: 727 LRAEEASLQDSLSKLSALNESLAQDK-LDLNRLVAQ-LEEEKSALQGRQRQAEQ------ 778

Query: 132 PTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDM------ 185
             A V  E+Q+ LE+   +     Q LE  ++V E  Q+  +    TL+ +         
Sbjct: 779 -EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837

Query: 186 ---QDLNGNNQSV--TRQKMQQLEQMLTALDQMRRSIVSELAGL---LSAMEYVQKTLTD 237
              + L+G  Q +   R++ Q+  + L    + + ++  E AGL   L A E   +TL++
Sbjct: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSE 897

Query: 238 E 238
           E
Sbjct: 898 E 898


>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
           sapiens]
          Length = 1002

 Score = 38.9 bits (89), Expect = 0.017
 Identities = 37/132 (28%), Positives = 56/132 (42%), Gaps = 10/132 (7%)

Query: 109 LWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENL 168
           L  E   LQTA    Q   +           + + L   LQ  R+RV +LE+ +  V   
Sbjct: 226 LVSEKAELQTALAHTQHAARQKEG-------ESEDLASRLQYSRRRVGELERALSAVSTQ 278

Query: 169 QDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAM 228
           Q   D   K L  + D   L     +   Q  + L+Q  + L++  R +V+E AG+   +
Sbjct: 279 QKKADRYNKELTKERDALRLELYKNT---QSNEDLKQEKSELEEKLRVLVTEKAGMQLNL 335

Query: 229 EYVQKTLTDEEL 240
           E +QK L   EL
Sbjct: 336 EELQKKLEMTEL 347



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 56/257 (21%), Positives = 111/257 (43%), Gaps = 48/257 (18%)

Query: 50  ESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCL 109
           E  A L  H  LG++ +   R LQ     Y  NL+      + R  +   ++  +     
Sbjct: 370 EERAQLEAH--LGQVMESV-RQLQMERDKYAENLKGESAMWRQRMQQMSEQVHTLREEKE 426

Query: 110 WEESRLLQTAATAAQQGGQANHPTA----AVVTEKQQMLEQHLQDVRKRVQDLEQKMKVV 165
              SR+ +   + A+   Q   P      A  +E +Q L+   + +RK ++ L  ++   
Sbjct: 427 CSMSRVQELETSLAELRNQMAEPPPPEPPAGPSEVEQQLQAEAEHLRKELEGLAGQL--- 483

Query: 166 ENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAG-- 223
                           Q  +QD    N+ ++R   +Q E++L    ++ R+  +EL G  
Sbjct: 484 ----------------QAQVQD----NEGLSRLNREQEERLL----ELERA--AELWGEQ 517

Query: 224 ------LLSAMEYVQKTLTDEELADWKRRQQIACI-GGPPNICLDRLENWITSLAESQLQ 276
                 +L  M+  + T++     + + ++Q+A +  G   +  + +E  ITS  +S+  
Sbjct: 518 AEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENME--ITSALQSEQH 575

Query: 277 TRQQI-KKLEELQQKVS 292
            ++++ KKL ELQ+K+S
Sbjct: 576 VKRELGKKLGELQEKLS 592


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 45/219 (20%), Positives = 95/219 (43%), Gaps = 24/219 (10%)

Query: 91   QSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQD 150
            + + +E+  ++A       W+  +L +     AQ+          +   K++M E+  + 
Sbjct: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798

Query: 151  VRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTAL 210
             RKR Q +E+KMK+ +          K  +    M++L  N   + ++K   L Q    L
Sbjct: 1799 GRKREQLIEKKMKLAQ----------KRERWINSMEELTKNKMILYQKK--NLAQEKKNL 1846

Query: 211  DQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSL 270
             Q +  +      LL    Y ++ LT  +    K+  Q+    G  N  L ++E  +T  
Sbjct: 1847 AQEKEKLAQRKENLL----YNKERLTHSK----KQLVQVKNKLGMFNKILAQVEEKLTQE 1898

Query: 271  AESQLQTRQQI----KKLEELQQKVSYKGDPIVQHRPML 305
             E+ ++ ++++    KKL +++  ++ K + + Q +  L
Sbjct: 1899 KETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKL 1937


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 55/253 (21%), Positives = 108/253 (42%), Gaps = 45/253 (17%)

Query: 62   GEIDQQYSRFLQESNVLYQHNLR------RIKQFLQSRYLEKPMEIARIVARCLWEESRL 115
            G ++QQ    LQE+  L +  L       +++  LQ +     +++   V+R +     L
Sbjct: 1988 GPVEQQ---LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI----EL 2040

Query: 116  LQTAATAAQQGGQANHPTAAVVTEKQQMLEQ------HLQDV-RKRVQDLEQKMKVVENL 168
             Q   T      Q N      + + ++ L++      H +DV ++ +Q LEQ++KVV   
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100

Query: 169  QDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAM 228
            Q   +   + ++   +            ++K  +  ++L + +Q++R I  E    +  +
Sbjct: 2101 QPISEHQTREVEQLANH----------LKEKTDKCSELLLSKEQLQRDI-QERNEEIEKL 2149

Query: 229  EYVQKTLTDEELADWKRRQQIACIGGPPNICL-----------DRLENWITSLAESQLQT 277
            E+  + L    L +   R+    +   P + L           DR E  IT+L E   Q 
Sbjct: 2150 EFRVRELEQALLVE--DRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2207

Query: 278  RQQIK-KLEELQQ 289
            R++++ K EE+QQ
Sbjct: 2208 REELENKNEEVQQ 2220



 Score = 33.9 bits (76), Expect = 0.54
 Identities = 47/217 (21%), Positives = 90/217 (41%), Gaps = 24/217 (11%)

Query: 109 LWEESRLLQTAATAAQQG----GQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKV 164
           L E+S+ LQ      Q         +  TAA + + +Q +  H Q + ++   LE   K 
Sbjct: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKK 290

Query: 165 VENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGL 224
            E+      F  + +K     QD     + V     +++++  T ++++   I+ E    
Sbjct: 291 KEDFTMQISFLQEKIKVYEMEQD-----KKVENSNKEEIQEKETIIEELNTKIIEEEK-- 343

Query: 225 LSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL 284
              +E   K  T ++L    + Q +       N  +  ++  +T+  + + Q+ ++IK+L
Sbjct: 344 -KTLELKDKLTTADKLLGELQEQIV-----QKNQEIKNMKLELTNSKQKERQSSEEIKQL 397

Query: 285 ----EELQQ---KVSYKGDPIVQHRPMLEERIVELFR 314
               EELQ+   K S     IVQ      +R +E  R
Sbjct: 398 MGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLR 434



 Score = 30.4 bits (67), Expect = 6.0
 Identities = 35/153 (22%), Positives = 62/153 (40%), Gaps = 25/153 (16%)

Query: 152  RKRVQDLEQKMKVVENLQDDF-------DFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLE 204
            R R +++EQ  +V+E LQ +          N  +L  + D   L      V  +K+   +
Sbjct: 2335 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD--SLKHQLDVVIAEKLALEQ 2392

Query: 205  QMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPP----NICL 260
            Q+ TA ++M     + +  +L    +    LT E  +  + R+ +  I   P    N+ +
Sbjct: 2393 QVETANEEM-----TFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAI 2447

Query: 261  D-------RLENWITSLAESQLQTRQQIKKLEE 286
            D        LE  +T  A   L+ +   K  EE
Sbjct: 2448 DHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480


>gi|112734867 retinitis pigmentosa GTPase regulator interacting
           protein 1 [Homo sapiens]
          Length = 1286

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 34/129 (26%), Positives = 67/129 (51%), Gaps = 16/129 (12%)

Query: 139 EKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNG----NNQS 194
           E   +L+  L++ ++RV+DLE++ K+   L D++D   K L+S  D  D +     +N+ 
Sbjct: 348 EDVSILQMTLKEFQERVEDLEKERKL---LNDNYD---KLLESMLDSSDSSSQPHWSNEL 401

Query: 195 VTRQKMQQLEQMLTALD---QMRRSIVSELAGLLSAMEYVQKTLTD---EELADWKRRQQ 248
           +  Q  QQ+ Q+   LD   + +R ++ EL+   +  E ++  +T+   +   + +  Q 
Sbjct: 402 IAEQLQQQVSQLQDQLDAELEDKRKVLLELSREKAQNEDLKLEVTNILQKHKQEVELLQN 461

Query: 249 IACIGGPPN 257
            A I  PP+
Sbjct: 462 AATISQPPD 470


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 64/311 (20%), Positives = 131/311 (42%), Gaps = 49/311 (15%)

Query: 35   APWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHN------------ 82
            A W E ++   A+SK+SH        + ++  +   +  E+N L +              
Sbjct: 1019 AIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078

Query: 83   --LRRIKQFLQSRYLEKPMEIARIV--ARCLWEESRLLQTAATAAQQGGQANHPTAAVVT 138
              ++++K+ LQ + +   ++I  +V   R L E ++ + T   A  +  +    T  V  
Sbjct: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGV-TCYKAKIKELETILETQKVEC 1137

Query: 139  EKQQMLEQHLQDVRKRVQDLEQKMK-VVENLQDDF----DFNYKTLKSQGDMQDLNGNNQ 193
                 LEQ + +    +  LE+ +K   E+LQD      D N K LK + ++  L  N Q
Sbjct: 1138 SHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQ 1197

Query: 194  SV-------------TRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
             +              RQ+ ++L++ L+A     +++ ++L         +++ LTD + 
Sbjct: 1198 DMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK- 1256

Query: 241  ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
               K+ +Q+        + + R E+ +  +  ++L+     KK  +  Q++  K   I Q
Sbjct: 1257 ---KQIKQV-----QKEVSVMRDEDKLLRIKINELE-----KKKNQCSQELDMKQRTIQQ 1303

Query: 301  HRPMLEERIVE 311
             +  L  + VE
Sbjct: 1304 LKEQLNNQKVE 1314


>gi|157266264 pleckstrin homology-like domain, family B, member 3
           [Homo sapiens]
          Length = 640

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 47/230 (20%), Positives = 92/230 (40%), Gaps = 39/230 (16%)

Query: 85  RIKQFLQSRYLEKPMEIARIVARCLWEESR-LLQTAATAAQQGGQANHPTAAVVTEKQQM 143
           RI+  ++   L   +   R+ AR   E+ R LL+  A + Q+G Q        +++++  
Sbjct: 130 RIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDR 189

Query: 144 LEQHLQDVRKR------------------VQDLEQKMKVVENLQDDFDFNYKTLKSQGDM 185
           LE   Q +RK                   VQ++ +++ V +   +D +F     +S+ + 
Sbjct: 190 LEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEE 249

Query: 186 QDLNGNNQSVTRQKMQQ------------LEQMLTALDQMRRSIVSELA----GLLSAME 229
           +D +     V   K+Q+            L+  +  L++  +S+  ++A    GL    E
Sbjct: 250 EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKE 309

Query: 230 YVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQ 279
              + L+ E      R  ++ C+ G P          +T L  +Q   RQ
Sbjct: 310 EALQALSQER----SRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQ 355


>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
          Length = 783

 Score = 38.1 bits (87), Expect = 0.029
 Identities = 43/214 (20%), Positives = 100/214 (46%), Gaps = 46/214 (21%)

Query: 133 TAAVVTEKQQMLE------QHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQ 186
           T   ++EKQQ+ E      Q+   V+++ Q+ +QK K++    D+     +TL+ + ++ 
Sbjct: 372 TDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLL 431

Query: 187 DLNGNNQSVTRQKMQQLEQMLTALDQMRRSI------VSELAGLLSAMEYVQKTLTDEEL 240
           ++  + Q   + ++QQ E +L  L+  +R          EL+  LS ++  ++ L +E L
Sbjct: 432 EMTCSQQ---QSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYL 488

Query: 241 A------------DWKRRQQIACIGGPPNICLDRLENWITSLAE------SQLQ-----T 277
                        + K  QQ         + L +++  +T+  E      +Q +      
Sbjct: 489 RLLKLLNVHVRNYNEKHHQQ--------KVKLQKVKYRLTNEVELRDKRINQFEDEIGIL 540

Query: 278 RQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVE 311
           + +I+K + +Q +++ + D ++  +  L+E+++E
Sbjct: 541 QHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIE 574


>gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens]
          Length = 636

 Score = 38.1 bits (87), Expect = 0.029
 Identities = 29/95 (30%), Positives = 47/95 (49%), Gaps = 7/95 (7%)

Query: 139 EKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVT-- 196
           +K   L Q L D++K+V DLE +    E  Q DFD      KS+ +M++ +    +    
Sbjct: 333 QKITELRQKLADLQKQVTDLEAER---EQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAK 389

Query: 197 --RQKMQQLEQMLTALDQMRRSIVSELAGLLSAME 229
             RQK++ L+  L+ L + R     E+  L  A+E
Sbjct: 390 ELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALE 424


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 38.1 bits (87), Expect = 0.029
 Identities = 37/173 (21%), Positives = 74/173 (42%), Gaps = 20/173 (11%)

Query: 127  GQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKS--QGD 184
            GQA     A+   + +  +Q L  ++K   DL+     ++N    F    K ++   + +
Sbjct: 1564 GQAER---ALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620

Query: 185  MQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSA--MEYVQKTLTDEELAD 242
               L+    +  R+K+ Q ++   AL +  R    EL   +++   +  +K+   +ELA+
Sbjct: 1621 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAE 1680

Query: 243  WKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKG 295
             K++             +D L +W+TS+  S  Q    +  +E+L      KG
Sbjct: 1681 NKKK-------------IDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 1720


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 38.1 bits (87), Expect = 0.029
 Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 38/236 (16%)

Query: 107  RCLWEESRLLQTA------ATAAQQGGQANHPTAAVVTEK-------------QQMLEQH 147
            R L EE   L+T       +TA QQ  +A       V +K             Q+M ++H
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 148  LQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQ-----GDMQDLNGNNQSVTRQK--- 199
             Q V +  + LEQ  +   NL    D N +TL+ +     G+++ L    Q V  +K   
Sbjct: 1202 AQAVEELTEQLEQFKRAKANL----DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257

Query: 200  ---MQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPP 256
               +Q+L+   +  ++ R  +  ++  L + +E V   L + E    K  + +A +    
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ- 1316

Query: 257  NICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVEL 312
               L   +  +      +L    ++++LEE +  +  + D  ++ +  LE  I  L
Sbjct: 1317 ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 35/181 (19%), Positives = 77/181 (42%), Gaps = 20/181 (11%)

Query: 139  EKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQ 198
            E+ Q  E  LQ  ++R Q  E ++K +E                          +++ ++
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLT-----------------EEKNLLQE 894

Query: 199  KMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNI 258
            ++Q   ++    ++MR  + ++   L   +  ++  L +EE    + + +   +      
Sbjct: 895  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 259  CLDRLENWITSLAESQLQ---TRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRN 315
              ++LE    +  + QL+      +IKKLE+    +  + + + + R +LEERI +L  N
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 316  L 316
            L
Sbjct: 1015 L 1015



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 75/457 (16%), Positives = 185/457 (40%), Gaps = 54/457 (11%)

Query: 8    QQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATL---------VFH 58
            QQ     L++L Q +S     E +  L   ++++   YA ++E    L         + H
Sbjct: 868  QQKAENELKELEQKHSQL--TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925

Query: 59   NLLGEIDQQYSRFLQ---ESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRL 115
             +   ++++  R  Q   E   + Q  L   +Q  +     + +++ ++ A     E+++
Sbjct: 926  EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA-----EAKI 980

Query: 116  LQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFN 175
             +          Q N      +++++++LE+ + D+   + + E+K K +  L++  +  
Sbjct: 981  KKLEDEILVMDDQNNK-----LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035

Query: 176  YKTL--------KSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSA 227
               L        KS+ +++ L    +       +Q+  +   + +++  +  +   L +A
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095

Query: 228  MEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEEL 287
            +  +   +  +  A  K R+    + G  +   + L++   +  +++ Q R   ++LE L
Sbjct: 1096 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151

Query: 288  QQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTT 347
            + ++    D     + +  +R  E+   ++K A   E +       +        V+  T
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209

Query: 348  KVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAE 407
            +     K  + N   K K  ++K++ D+A      +  +LG   +     E     L A+
Sbjct: 1210 EQLEQFKRAKANLD-KNKQTLEKENADLAG-----ELRVLG---QAKQEVEHKKKKLEAQ 1260

Query: 408  FKHLTLREQRCGNGGRANCDASLIVTEELHLITFETE 444
             + L   + +C +G RA  +    + +++H +  E E
Sbjct: 1261 VQEL---QSKCSDGERARAE----LNDKVHKLQNEVE 1290


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,855,552
Number of Sequences: 37866
Number of extensions: 1140472
Number of successful extensions: 4644
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 250
Number of HSP's that attempted gapping in prelim test: 4093
Number of HSP's gapped (non-prelim): 759
length of query: 722
length of database: 18,247,518
effective HSP length: 110
effective length of query: 612
effective length of database: 14,082,258
effective search space: 8618341896
effective search space used: 8618341896
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.