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Search of human proteins with 108860679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
(323 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 655 0.0
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 216 3e-56
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 214 1e-55
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 214 1e-55
gi|13259541 uncoupling protein 2 [Homo sapiens] 181 8e-46
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 181 1e-45
gi|11225256 uncoupling protein 1 [Homo sapiens] 171 6e-43
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 155 6e-38
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 149 3e-36
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 137 1e-32
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 128 8e-30
gi|41462412 solute carrier family 25, member 35 [Homo sapiens] 100 1e-21
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 95 7e-20
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 94 1e-19
gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 92 5e-19
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade... 90 3e-18
gi|21687151 mitochondrial solute carrier protein [Homo sapiens] 86 4e-17
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 85 1e-16
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 85 1e-16
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 85 1e-16
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 84 1e-16
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 82 8e-16
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 80 2e-15
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 80 2e-15
gi|60460887 solute carrier family 25, member 42 [Homo sapiens] 79 5e-15
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 77 2e-14
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 77 2e-14
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 77 2e-14
gi|46094065 mitochondrial carrier family protein [Homo sapiens] 77 2e-14
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 77 2e-14
>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
Length = 323
Score = 655 bits (1690), Expect = 0.0
Identities = 323/323 (100%), Positives = 323/323 (100%)
Query: 1 MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGD 60
MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGD
Sbjct: 1 MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGD 60
Query: 61 GARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS 120
GARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS
Sbjct: 61 GARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS 120
Query: 121 EDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKI 180
EDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKI
Sbjct: 121 EDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKI 180
Query: 181 LAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGL 240
LAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGL
Sbjct: 181 LAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGL 240
Query: 241 VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRM 300
VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRM
Sbjct: 241 VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRM 300
Query: 301 TPWSMVFWLTYEKIREMSGVSPF 323
TPWSMVFWLTYEKIREMSGVSPF
Sbjct: 301 TPWSMVFWLTYEKIREMSGVSPF 323
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 216 bits (549), Expect = 3e-56
Identities = 115/295 (38%), Positives = 177/295 (60%), Gaps = 14/295 (4%)
Query: 23 FLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEE 82
F+ G A+ AE TFP+DLTKTRLQ+QG+ D + YRGM+ + I EE
Sbjct: 9 FVYGGLASITAECGTFPIDLTKTRLQIQGQT-----NDAKFKEIRYRGMLHALVRIGREE 63
Query: 83 GFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQ 142
G L+ G+ PA+ R Y ++ TY+ L+ + + EDE P+ +VI G+++GVI
Sbjct: 64 GLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPI--NVICGILSGVISS 121
Query: 143 FLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAAL 202
+ANPTD++K++MQ + ++G G+ F I + G RGLW G QRAA+
Sbjct: 122 TIANPTDVLKIRMQAQSNT-IQG------GMIGNFMNIYQQEGTRGLWKGVSLTAQRAAI 174
Query: 203 VNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRD 262
V +L YD K +L+L+ + D + TH LSS GL ++ P DV+++R+MNQ
Sbjct: 175 VVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVL 234
Query: 263 KQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREM 317
+ GR Y + DCL+Q + EGF +LYKGF P+WLR+ PW+++F++TYE+++++
Sbjct: 235 RDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKL 289
Score = 75.5 bits (184), Expect = 6e-14
Identities = 47/166 (28%), Positives = 86/166 (51%), Gaps = 8/166 (4%)
Query: 128 WKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGK-RKLEGKPLRFRGVHHAFAKILAEGGI 186
WK + G +A + + P DL K ++Q++G+ + K +R+RG+ HA +I E G+
Sbjct: 6 WKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGL 65
Query: 187 RGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILG 246
+ L++G P + R A + TY ++K L + P ++ + + + + SG+++S +
Sbjct: 66 KALYSGIAPAMLRQASYGTIKIGTYQSLKR-LFIERPEDETLPINVICGILSGVISSTIA 124
Query: 247 TPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKG 292
P DV+K R+ Q QG G++ + Q EG L+KG
Sbjct: 125 NPTDVLKIRMQAQSNTIQG-GMIGN-----FMNIYQQEGTRGLWKG 164
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 214 bits (544), Expect = 1e-55
Identities = 118/296 (39%), Positives = 181/296 (61%), Gaps = 17/296 (5%)
Query: 23 FLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEE 82
F+ G A+ VAE TFP+DLTKTRLQ+QG++ AR + YRGM I +EE
Sbjct: 44 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARF-----KEIKYRGMFHALFRICKEE 98
Query: 83 GFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQ 142
G L L+ G+ PA+ R Y ++ Y+ L+ + + EDE L ++I G+++GVI
Sbjct: 99 GVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDE--TLLINMICGVVSGVISS 156
Query: 143 FLANPTDLVKVQMQMEGKRKLEGKPLRFRG-VHHAFAKILAEGGIRGLWAGWVPNIQRAA 201
+ANPTD++K++MQ +G F+G + +F I + G RGLW G VP QRAA
Sbjct: 157 TIANPTDVLKIRMQAQGSL--------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 208
Query: 202 LVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPR 261
+V +L YD K +L+L+ + D I+TH +SS GL ++ P DV+++R+MNQ R
Sbjct: 209 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQ-R 267
Query: 262 DKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREM 317
G LYK + D +++ + EGF +LYKGF P+WLR+ PW+++F++TYE+++ +
Sbjct: 268 AIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 323
Score = 77.4 bits (189), Expect = 2e-14
Identities = 46/171 (26%), Positives = 88/171 (51%), Gaps = 10/171 (5%)
Query: 128 WKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKR-KLEGKPLRFRGVHHAFAKILAEGGI 186
WK + G +A ++ +F P DL K ++Q++G+ K +++RG+ HA +I E G+
Sbjct: 41 WKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGV 100
Query: 187 RGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILG 246
L++G P + R A + Y ++K V ++ ++ + + + SG+++S +
Sbjct: 101 LALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLE-DETLLINMICGVVSGVISSTIA 159
Query: 247 TPADVIKSRIMNQPRDKQGRGLLYKSS-TDCLIQAVQGEGFMSLYKGFLPS 296
P DV+K R+ Q +G L++ S I Q EG L++G +P+
Sbjct: 160 NPTDVLKIRM-------QAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPT 203
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 214 bits (544), Expect = 1e-55
Identities = 118/296 (39%), Positives = 181/296 (61%), Gaps = 17/296 (5%)
Query: 23 FLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEE 82
F+ G A+ VAE TFP+DLTKTRLQ+QG++ AR + YRGM I +EE
Sbjct: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARF-----KEIKYRGMFHALFRICKEE 95
Query: 83 GFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQ 142
G L L+ G+ PA+ R Y ++ Y+ L+ + + EDE L ++I G+++GVI
Sbjct: 96 GVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDE--TLLINMICGVVSGVISS 153
Query: 143 FLANPTDLVKVQMQMEGKRKLEGKPLRFRG-VHHAFAKILAEGGIRGLWAGWVPNIQRAA 201
+ANPTD++K++MQ +G F+G + +F I + G RGLW G VP QRAA
Sbjct: 154 TIANPTDVLKIRMQAQGSL--------FQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAA 205
Query: 202 LVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPR 261
+V +L YD K +L+L+ + D I+TH +SS GL ++ P DV+++R+MNQ R
Sbjct: 206 IVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQ-R 264
Query: 262 DKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREM 317
G LYK + D +++ + EGF +LYKGF P+WLR+ PW+++F++TYE+++ +
Sbjct: 265 AIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRL 320
Score = 77.4 bits (189), Expect = 2e-14
Identities = 46/171 (26%), Positives = 88/171 (51%), Gaps = 10/171 (5%)
Query: 128 WKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKR-KLEGKPLRFRGVHHAFAKILAEGGI 186
WK + G +A ++ +F P DL K ++Q++G+ K +++RG+ HA +I E G+
Sbjct: 38 WKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGV 97
Query: 187 RGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILG 246
L++G P + R A + Y ++K V ++ ++ + + + SG+++S +
Sbjct: 98 LALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLE-DETLLINMICGVVSGVISSTIA 156
Query: 247 TPADVIKSRIMNQPRDKQGRGLLYKSS-TDCLIQAVQGEGFMSLYKGFLPS 296
P DV+K R+ Q +G L++ S I Q EG L++G +P+
Sbjct: 157 NPTDVLKIRM-------QAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPT 200
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 181 bits (459), Expect = 8e-46
Identities = 101/294 (34%), Positives = 166/294 (56%), Gaps = 14/294 (4%)
Query: 22 KFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEE 81
KFL +G AA +A+L TFPLD K RLQ+QGE+ + A SA YRG++ T L ++
Sbjct: 16 KFLGAGTAACIADLITFPLDTAKVRLQIQGES---QGPVRATASAQYRGVMGTILTMVRT 72
Query: 82 EGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIG 141
EG L+ G+ + R + ++ R+ Y+ +++ F EH + ++ G G +
Sbjct: 73 EGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQ--FYTKGSEHASIGSRLLAGSTTGALA 130
Query: 142 QFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAA 201
+A PTD+VKV+ Q + + G R++ +A+ I E G RGLW G PN+ R A
Sbjct: 131 VAVAQPTDVVKVRFQAQARA---GGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNA 187
Query: 202 LVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPR 261
+VN +L TYD +K L+ + D++ H S+ +G +++ +P DV+K+R MN
Sbjct: 188 IVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL 247
Query: 262 DKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIR 315
+ Y S+ C + +Q EG + YKGF+PS+LR+ W++V ++TYE+++
Sbjct: 248 GQ------YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295
Score = 63.5 bits (153), Expect = 2e-10
Identities = 51/191 (26%), Positives = 87/191 (45%), Gaps = 12/191 (6%)
Query: 132 IGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLR------FRGVHHAFAKILAEGG 185
+G A I + P D KV++Q++G+ + P+R +RGV ++ G
Sbjct: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQ---GPVRATASAQYRGVMGTILTMVRTEG 74
Query: 186 IRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASIL 245
R L+ G V +QR + YD+VK + + +I + L+ +G +A +
Sbjct: 75 PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSE-HASIGSRLLAGSTTGALAVAV 133
Query: 246 GTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSM 305
P DV+K R Q R G G Y+S+ + + EGF L+KG P+ R +
Sbjct: 134 AQPTDVVKVRFQAQAR--AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNC 191
Query: 306 VFWLTYEKIRE 316
+TY+ I++
Sbjct: 192 AELVTYDLIKD 202
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 181 bits (458), Expect = 1e-45
Identities = 108/310 (34%), Positives = 165/310 (53%), Gaps = 17/310 (5%)
Query: 20 ASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGII 79
A KFL +G AA A+L TFPLD K RLQ+QGE + YRG++ T L ++
Sbjct: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTA----RLVQYRGVLGTILTMV 69
Query: 80 EEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGV 139
EG + G+ + R + ++ R+ Y+ +++V K D L ++ G G
Sbjct: 70 RTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNS-SLTTRILAGCTTGA 128
Query: 140 IGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQR 199
+ A PTD+VKV+ Q ++ G A+ I E G+RGLW G +PNI R
Sbjct: 129 MAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMR 188
Query: 200 AALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQ 259
A+VN ++ TYD +K L+ L DN H +S+ +G A+++ +P DV+K+R MN
Sbjct: 189 NAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNS 248
Query: 260 PRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIR---- 315
P + Y S DC+I+ V EG + YKGF PS+LR+ W++V ++TYE+++
Sbjct: 249 PPGQ------YFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALM 302
Query: 316 --EMSGVSPF 323
+M SPF
Sbjct: 303 KVQMLRESPF 312
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 171 bits (434), Expect = 6e-43
Identities = 92/294 (31%), Positives = 166/294 (56%), Gaps = 17/294 (5%)
Query: 26 SGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFL 85
+G AA +A++ TFPLD K RLQ+QGE + + Y+G++ T +++ EG +
Sbjct: 20 AGIAACLADVITFPLDTAKVRLQVQGECPTSSV-------IRYKGVLGTITAVVKTEGRM 72
Query: 86 KLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLA 145
KL+ G+ + R + + R+ Y+ ++E + E L ++ G+ G + F+
Sbjct: 73 KLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAP-SLGSKILAGLTTGGVAVFIG 131
Query: 146 NPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNM 205
PT++VKV++Q + L G R+ G ++A+ I G+ GLW G PN+ R+ ++N
Sbjct: 132 QPTEVVKVRLQAQSH--LHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINC 189
Query: 206 GDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQG 265
+L TYD +K V N L D++ H +S+L +G A+ + +P DV+K+R +N P +
Sbjct: 190 TELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQ-- 247
Query: 266 RGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKI-REMS 318
YKS +C ++ EG + +KG +PS+LR+ W+++ ++ +E++ RE+S
Sbjct: 248 ----YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELS 297
Score = 60.5 bits (145), Expect = 2e-09
Identities = 46/197 (23%), Positives = 86/197 (43%), Gaps = 2/197 (1%)
Query: 120 SEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAK 179
+ D H L + +A + + P D KV++Q++G+ +R++GV
Sbjct: 6 ASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECP-TSSVIRYKGVLGTITA 64
Query: 180 ILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSG 239
++ G L++G +QR + YDTV+ +L ++ + L+ L +G
Sbjct: 65 VVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTG 124
Query: 240 LVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLR 299
VA +G P +V+K R+ Q G Y + + EG L+KG P+ +R
Sbjct: 125 GVAVFIGQPTEVVKVRLQAQSH-LHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMR 183
Query: 300 MTPWSMVFWLTYEKIRE 316
+ +TY+ ++E
Sbjct: 184 SVIINCTELVTYDLMKE 200
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 155 bits (391), Expect = 6e-38
Identities = 94/273 (34%), Positives = 141/273 (51%), Gaps = 11/273 (4%)
Query: 20 ASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGII 79
A KFL +G AA A+L TFPLD K RLQ+QGE + YRG++ T L ++
Sbjct: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTA----RLVQYRGVLGTILTMV 69
Query: 80 EEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGV 139
EG + G+ + R + ++ R+ Y+ +++V K D L ++ G G
Sbjct: 70 RTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNS-SLTTRILAGCTTGA 128
Query: 140 IGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQR 199
+ A PTD+VKV+ Q ++ G A+ I E G+RGLW G +PNI R
Sbjct: 129 MAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMR 188
Query: 200 AALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQ 259
A+VN ++ TYD +K L+ L DN H +S+ +G A+++ +P DV+K+R MN
Sbjct: 189 NAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNS 248
Query: 260 PRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKG 292
P + Y S DC+I+ V EG + YKG
Sbjct: 249 PPGQ------YFSPLDCMIKMVAQEGPTAFYKG 275
Score = 51.2 bits (121), Expect = 1e-06
Identities = 43/188 (22%), Positives = 77/188 (40%), Gaps = 3/188 (1%)
Query: 132 IGGMMAGVIGQFLANPTDLVKVQMQMEGKRKL--EGKPLRFRGVHHAFAKILAEGGIRGL 189
+G A + P D KV++Q++G+ + + +++RGV ++ G
Sbjct: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
Query: 190 WAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPA 249
+ G V +QR + YD+VK ++ T L+ +G +A P
Sbjct: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPT 137
Query: 250 DVIKSRIMNQPRDKQGRG-LLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFW 308
DV+K R R Y + D + EG L+KG LP+ +R +
Sbjct: 138 DVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEV 197
Query: 309 LTYEKIRE 316
+TY+ ++E
Sbjct: 198 VTYDILKE 205
>gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
Length = 314
Score = 149 bits (376), Expect = 3e-36
Identities = 94/299 (31%), Positives = 153/299 (51%), Gaps = 13/299 (4%)
Query: 18 PRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALG 77
P++ KFL G A A + PLDL K R+Q+ GE A R Y+
Sbjct: 20 PKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTR---------EYKTSFHALTS 70
Query: 78 IIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMA 137
I++ EG ++ G++ + R Y+ R+ Y L E + G L K+VIG M A
Sbjct: 71 ILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIG-MTA 129
Query: 138 GVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNI 197
G G F+ P ++ ++M +G+ + + ++ V +A +I E G+ LW G +P +
Sbjct: 130 GATGAFVGTPAEVALIRMTADGRLPADQRR-GYKNVFNALIRITREEGVLTLWRGCIPTM 188
Query: 198 QRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIM 257
RA +VN L +Y K +L+ + DNI+ H +S+ SGLV + P D+ K+RI
Sbjct: 189 ARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQ 248
Query: 258 NQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIRE 316
N R G+ YK+ D L + V+ EGF SL+KGF P + R+ P +++ ++ E++ +
Sbjct: 249 NM-RMIDGKP-EYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
>gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
Length = 287
Score = 137 bits (345), Expect = 1e-32
Identities = 91/302 (30%), Positives = 151/302 (50%), Gaps = 24/302 (7%)
Query: 19 RASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGI 78
R S++ G A+ A T PLDL K LQ Q E L G AL +
Sbjct: 6 RVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTG--------------MALRV 51
Query: 79 IEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAG 138
+ +G L L+ G++ ++ R + YS R YE +R+ V K P + V+ G ++G
Sbjct: 52 VRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDRV-AKGSQGPLPFHEKVLLGSVSG 110
Query: 139 VIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQ 198
+ G F+ P DLV V+MQ + K +G+ + ++ E G+R L++G
Sbjct: 111 LAGGFVGTPADLVNVRMQNDVKLP-QGQRRNYAHALDGLYRVAREEGLRRLFSGATMASS 169
Query: 199 RAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMN 258
R ALV +G L+ YD K ++ L DNI TH ++S +G A+ L P DV+K+R+MN
Sbjct: 170 RGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMN 229
Query: 259 QPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREMS 318
+ QG C ++ + G ++ YKG +P+ +R+ P +++ ++ E++R+
Sbjct: 230 SKGEYQG-------VFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNF 281
Query: 319 GV 320
G+
Sbjct: 282 GI 283
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 128 bits (321), Expect = 8e-30
Identities = 86/304 (28%), Positives = 151/304 (49%), Gaps = 13/304 (4%)
Query: 18 PRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALG 77
P A +L A +A + T PL++ KTRLQ+QGE L G R PY G + +
Sbjct: 5 PPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGE--LQARGTYPR---PYHGFIASVAA 59
Query: 78 IIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMA 137
+ +G L +G+ + + +G R Y + + +V+ G +A
Sbjct: 60 VARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGG------TVVAGAVA 113
Query: 138 GVIGQFLANPTDLVKVQMQMEGKRKLE-GKPLRFRGVHHAFAKILAEGGIRGLWAGWVPN 196
G +G F+ +P L+K Q+Q + + G + V A I + G+ GLW G
Sbjct: 114 GALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGA 173
Query: 197 IQRAALVNMGDLTTYDTVKHYLVLNTPL-EDNIMTHGLSSLCSGLVASILGTPADVIKSR 255
+ R + + L T+ + K ++ L ED+ + + S + ++ TP DV+ +R
Sbjct: 174 VPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTR 233
Query: 256 IMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIR 315
+ NQP D GRG LY TDC+++ + EG ++LYKG P++LR+ P +++ L ++++R
Sbjct: 234 LYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR 293
Query: 316 EMSG 319
+++G
Sbjct: 294 KLAG 297
>gi|41462412 solute carrier family 25, member 35 [Homo sapiens]
Length = 295
Score = 100 bits (250), Expect = 1e-21
Identities = 81/265 (30%), Positives = 132/265 (49%), Gaps = 16/265 (6%)
Query: 23 FLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEE 82
FL+SG AA A + T PL++ KTR+Q+QGE L G R YR + + I + +
Sbjct: 3 FLMSGLAACGACVFTNPLEVVKTRMQLQGE--LQAPGTYQRH---YRNVFHAFITIGKVD 57
Query: 83 GFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREV--VFGKSEDEHYPLWKSVIGGMMAGVI 140
G L +G+ PA+ + +G R+ TY L E +E H P +S G MAGV+
Sbjct: 58 GLAALQKGLAPALLYQFLMNGIRLGTY-GLAEAGGYLHTAEGTHSPA-RSAAAGAMAGVM 115
Query: 141 GQFLANPTDLVKVQMQMEGKRKLE-GKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQR 199
G +L +P +VK +Q + ++ G + +G+ A +I + G+ GLW G + + R
Sbjct: 116 GAYLGSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPR 175
Query: 200 AALVNMGDLTTYDTVKHYL---VLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRI 256
+ + L T+ + K L + P + ++++ SG+ + P DV +R+
Sbjct: 176 VIVGSSTQLCTFSSTKDLLSQWEIFPPQSWKLAL--VAAMMSGIAVVLAMAPFDVACTRL 233
Query: 257 MNQPRDKQGRGLLYK-SSTDCLIQA 280
NQP D QG+ + K S+T C A
Sbjct: 234 YNQPTDAQGKNRVPKFSATSCSASA 258
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 95.1 bits (235), Expect = 7e-20
Identities = 79/298 (26%), Positives = 139/298 (46%), Gaps = 21/298 (7%)
Query: 24 LLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEG 83
L G AA V++ A P++ K LQ+Q A+ ++ AR Y+GMV + I E+G
Sbjct: 25 LAGGVAAAVSKTAVAPIERVKLLLQVQ--ASSKQISPEAR----YKGMVDCLVRIPREQG 78
Query: 84 FLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVF-GKSEDEHYPLW--KSVIGGMMAGVI 140
F W+G + R+ + +++ G ++++ + W ++ G AG
Sbjct: 79 FFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGAT 138
Query: 141 GQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRA 200
+ P D + ++ ++ + E + +F+G+ KI GI GL+ G+ ++Q
Sbjct: 139 SLCVVYPLDFARTRLGVDIGKGPEER--QFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGI 196
Query: 201 ALVNMGDLTTYDTVKHYL--VLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMN 258
+ YDTVK L TP + + + CSG IL P D ++ R+M
Sbjct: 197 IVYRASYFGAYDTVKGLLPKPKKTPFLVSFFIAQVVTTCSG----ILSYPFDTVRRRMMM 252
Query: 259 QPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIRE 316
Q + + + YK + DC ++ Q EG S ++G + LR T ++V L Y+KI+E
Sbjct: 253 QSGEAKRQ---YKGTLDCFVKIYQHEGISSFFRGAFSNVLRGTGGALVLVL-YDKIKE 306
Score = 52.8 bits (125), Expect = 4e-07
Identities = 40/173 (23%), Positives = 71/173 (41%), Gaps = 13/173 (7%)
Query: 129 KSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRG 188
K ++ G +A + + P + VK+ +Q++ K R++G+ +I E G
Sbjct: 22 KDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFS 81
Query: 189 LWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGT- 247
W G + N+ R + D K + E L++L SG A
Sbjct: 82 FWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLC 141
Query: 248 ---PADVIKSR----IMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGF 293
P D ++R I P ++Q +GL DC+++ + +G LY+GF
Sbjct: 142 VVYPLDFARTRLGVDIGKGPEERQFKGL-----GDCIMKIAKSDGIAGLYQGF 189
Score = 37.4 bits (85), Expect = 0.018
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 232 GLSSLCSGLVASILGT---PADVIKSRIMNQPRDKQ-GRGLLYKSSTDCLIQAVQGEGFM 287
G L G+ A++ T P + +K + Q KQ YK DCL++ + +GF
Sbjct: 21 GKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFF 80
Query: 288 SLYKGFLPSWLRMTPWSMVFWLTYEKIRE--MSGVS 321
S ++G L + +R P + + +K ++ MSGV+
Sbjct: 81 SFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVN 116
Score = 34.7 bits (78), Expect = 0.12
Identities = 25/107 (23%), Positives = 49/107 (45%), Gaps = 15/107 (14%)
Query: 10 LLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYR 69
LLP ++ P F ++ T + + ++P D + R+ MQ G+ R+ Y+
Sbjct: 213 LLPKPKKTPFLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQS-------GEAKRQ---YK 262
Query: 70 GMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGR--MVTYEHLRE 114
G + + I + EG ++G + R +GG +V Y+ ++E
Sbjct: 263 GTLDCFVKIYQHEGISSFFRGAFSNVLRG---TGGALVLVLYDKIKE 306
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 94.4 bits (233), Expect = 1e-19
Identities = 84/296 (28%), Positives = 137/296 (46%), Gaps = 22/296 (7%)
Query: 20 ASKFLLSGCAATVAELATF-PLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGI 78
AS+ +++G +A + E+ PLD+ KTR Q+Q A + Y+ +V + I
Sbjct: 13 ASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCAT---------DPNSYKSLVDSFRMI 63
Query: 79 IEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAG 138
+ EG ++G+ P I + T+E ++++ S P I G+ +G
Sbjct: 64 FQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLS---PALTFAIAGLGSG 120
Query: 139 VIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEG-GIRGLWAGWVPNI 197
+ + NP ++VKV +Q E V +A I EG G++GL G +
Sbjct: 121 LTEAIVVNPFEVVKVGLQANRNTFAEQPST----VGYARQIIKKEGWGLQGLNKGLTATL 176
Query: 198 QRAALVNMGDLTTYDTVKHYLVLNT-PLEDNIMTHGLSSLCSGLVASILGTPADVIKSRI 256
R + NM Y VK+ + +N P+ + G+ L SG +AS++ P DV KSRI
Sbjct: 177 GRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIG-LLSGTIASVINIPFDVAKSRI 235
Query: 257 MNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYE 312
P+ G + Y++ + Q EG ++LYKG LP +R+ P V L YE
Sbjct: 236 QG-PQPVPGE-IKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
Score = 44.3 bits (103), Expect = 1e-04
Identities = 29/82 (35%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
Query: 238 SGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSW 297
+GLV L P DV+K+R Q YKS D Q EG YKG LP
Sbjct: 23 AGLVEICLMHPLDVVKTRFQIQRCATDPNS--YKSLVDSFRMIFQMEGLFGFYKGILPPI 80
Query: 298 LRMTPWSMVFWLTYEKIREMSG 319
L TP V + T+E+ +++ G
Sbjct: 81 LAETPKRAVKFFTFEQYKKLLG 102
Score = 42.4 bits (98), Expect = 6e-04
Identities = 45/197 (22%), Positives = 85/197 (43%), Gaps = 15/197 (7%)
Query: 129 KSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRG 188
+ ++ G AG++ L +P D+VK + Q++ + P ++ + +F I G+ G
Sbjct: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQ---RCATDPNSYKSLVDSFRMIFQMEGLFG 71
Query: 189 LWAGWVPNIQRAALVNMGDLTTYDTVKHYL--VLNTPLEDNIMTHGLSSLCSGLVASILG 246
+ G +P I T++ K L V +P +T ++ L SGL +I+
Sbjct: 72 FYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPA----LTFAIAGLGSGLTEAIVV 127
Query: 247 TPADVIKSRIMNQPRD--KQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWS 304
P +V+K + +Q + Y I +G G L KG + R ++
Sbjct: 128 NPFEVVKVGLQANRNTFAEQPSTVGYARQ----IIKKEGWGLQGLNKGLTATLGRHGVFN 183
Query: 305 MVFWLTYEKIREMSGVS 321
MV++ Y ++ M V+
Sbjct: 184 MVYFGFYYNVKNMIPVN 200
Score = 39.7 bits (91), Expect = 0.004
Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 20/104 (19%)
Query: 12 PLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQ----MQGEAALARLGDGARESAP 67
P+ + W + LLSG T+A + P D+ K+R+Q + GE
Sbjct: 203 PILEFWRKFGIGLLSG---TIASVINIPFDVAKSRIQGPQPVPGEIK------------- 246
Query: 68 YRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEH 111
YR +T + +EEG L L++G+ P I R ++ YE+
Sbjct: 247 YRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEY 290
>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
Length = 298
Score = 92.4 bits (228), Expect = 5e-19
Identities = 74/303 (24%), Positives = 131/303 (43%), Gaps = 19/303 (6%)
Query: 20 ASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGII 79
A FL G AA +++ A P++ K LQ+Q Y+G+V + I
Sbjct: 9 AKDFLAGGIAAAISKTAVAPIERVKLLLQVQ------HASKQIAADKQYKGIVDCIVRIP 62
Query: 80 EEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIG----GM 135
+E+G L W+G + R+ + +++ G D+H W+ G G
Sbjct: 63 KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG-GVDKHTQFWRYFAGNLASGG 121
Query: 136 MAGVIGQFLANPTDLVKVQMQME-GKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWV 194
AG P D + ++ + GK G FRG+ KI GIRGL+ G+
Sbjct: 122 AAGATSLCFVYPLDFARTRLAADVGK---SGTEREFRGLGDCLVKITKSDGIRGLYQGFS 178
Query: 195 PNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKS 254
++Q + YDT K +L P +I+ + + VA ++ P D ++
Sbjct: 179 VSVQGIIIYRAAYFGVYDTAKG--MLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRR 236
Query: 255 RIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKI 314
R+M Q ++G ++Y + DC + + EG + +KG + LR + V L Y+++
Sbjct: 237 RMMMQ-SGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVL-YDEL 294
Query: 315 REM 317
+++
Sbjct: 295 KKV 297
>gi|55749577 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 4 [Homo
sapiens]
Length = 298
Score = 89.7 bits (221), Expect = 3e-18
Identities = 73/305 (23%), Positives = 129/305 (42%), Gaps = 19/305 (6%)
Query: 17 WPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTAL 76
W FL G AA V++ A P++ K LQ+Q Y+G++ +
Sbjct: 6 WSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQ------HASKQISAEKQYKGIIDCVV 59
Query: 77 GIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIG--- 133
I +E+GFL W+G + R+ + +++ G D H W+ G
Sbjct: 60 RIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLG-GVDRHKQFWRYFAGNLA 118
Query: 134 -GMMAGVIGQFLANPTDLVKVQMQME-GKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWA 191
G AG P D + ++ + GK + + F G+ KI G+RGL+
Sbjct: 119 SGGAAGATSLCFVYPLDFARTRLAADVGKGAAQRE---FHGLGDCIIKIFKSDGLRGLYQ 175
Query: 192 GWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADV 251
G+ ++Q + YDT K +L P +I + + VA ++ P D
Sbjct: 176 GFNVSVQGIIIYRAAYFGVYDTAKG--MLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDT 233
Query: 252 IKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTY 311
++ R+M Q ++G ++Y + DC + + EG + +KG + LR + V L Y
Sbjct: 234 VRRRMMMQ-SGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVL-Y 291
Query: 312 EKIRE 316
++I++
Sbjct: 292 DEIKK 296
Score = 43.9 bits (102), Expect = 2e-04
Identities = 39/203 (19%), Positives = 76/203 (37%), Gaps = 11/203 (5%)
Query: 122 DEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKIL 181
D + K + G +A + + P + VK+ +Q++ K +++G+ +I
Sbjct: 3 DHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIP 62
Query: 182 AEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLV 241
E G W G + N+ R + D K + + +L SG
Sbjct: 63 KEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGA 122
Query: 242 ASILGT----PADVIKSRIMNQPRDKQGRGLL---YKSSTDCLIQAVQGEGFMSLYKGFL 294
A P D ++R+ G+G + DC+I+ + +G LY+GF
Sbjct: 123 AGATSLCFVYPLDFARTRLAAD----VGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFN 178
Query: 295 PSWLRMTPWSMVFWLTYEKIREM 317
S + + ++ Y+ + M
Sbjct: 179 VSVQGIIIYRAAYFGVYDTAKGM 201
>gi|21687151 mitochondrial solute carrier protein [Homo sapiens]
Length = 341
Score = 85.9 bits (211), Expect = 4e-17
Identities = 70/295 (23%), Positives = 128/295 (43%), Gaps = 25/295 (8%)
Query: 22 KFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEE 81
+ L +G A T++ T PL+L LA++G + RG T +
Sbjct: 15 RLLCAGLAGTLSLSLTAPLELA---------TVLAQVGVVRGHA---RGPWATGHRVWRA 62
Query: 82 EGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIG 141
EG LW+G A R S ++ Y VV + H W S++ G +AG++
Sbjct: 63 EGLRALWKGNAVACLRLFPCSAVQLAAYRKF--VVLFTDDLGHISQWSSIMAGSLAGMVS 120
Query: 142 QFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAA 201
+ PTDL+K ++ M+ + +RG+ HAF+ I + G L+ G + A
Sbjct: 121 TIVTYPTDLIKTRLIMQNILEPS-----YRGLLHAFSTIYQQEGFLALYRGVSLTVVGAL 175
Query: 202 LVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLC-SGLVASILGTPADVIKSRIMNQP 260
+ G L Y ++ + N P + + +++C + V L P + +K ++ Q
Sbjct: 176 PFSAGSLLVYMNLEK--IWNGPRDQFSLPQNFANVCLAAAVTQTLSFPFETVKRKMQAQS 233
Query: 261 ---RDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYE 312
G + + + DC Q V+ +G + L+ G + L++ P+ + + T+E
Sbjct: 234 PYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFE 288
Score = 70.9 bits (172), Expect = 1e-12
Identities = 49/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%)
Query: 21 SKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIE 80
S + A V+ + T+P DL KTRL MQ YRG++ I +
Sbjct: 108 SSIMAGSLAGMVSTIVTYPTDLIKTRLIMQNIL-----------EPSYRGLLHAFSTIYQ 156
Query: 81 EEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVI 140
+EGFL L++GV+ + + +S G ++ Y +L ++ G + + L ++ +A +
Sbjct: 157 QEGFLALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPR--DQFSLPQNFANVCLAAAV 214
Query: 141 GQFLANPTDLVKVQMQMEGK--RKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNI 197
Q L+ P + VK +MQ + G + F G F +I+ G+ GLW G N+
Sbjct: 215 TQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANL 273
Score = 45.4 bits (106), Expect = 7e-05
Identities = 50/185 (27%), Positives = 83/185 (44%), Gaps = 20/185 (10%)
Query: 136 MAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVP 195
+AG + L P +L V Q+ R RG ++ G+R LW G
Sbjct: 21 LAGTLSLSLTAPLELATVLAQVGVVRG------HARGPWATGHRVWRAEGLRALWKGNAV 74
Query: 196 NIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHG--LSSLCSGLVASILGTPADVIK 253
R + L Y + ++VL T +I ++ +G+V++I+ P D+IK
Sbjct: 75 ACLRLFPCSAVQLAAY---RKFVVLFTDDLGHISQWSSIMAGSLAGMVSTIVTYPTDLIK 131
Query: 254 SR-IMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPW---SMVFWL 309
+R IM + RGLL+ ST Q EGF++LY+G + + P+ S++ ++
Sbjct: 132 TRLIMQNILEPSYRGLLHAFST-----IYQQEGFLALYRGVSLTVVGALPFSAGSLLVYM 186
Query: 310 TYEKI 314
EKI
Sbjct: 187 NLEKI 191
Score = 37.4 bits (85), Expect = 0.018
Identities = 23/87 (26%), Positives = 38/87 (43%), Gaps = 4/87 (4%)
Query: 29 AATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLW 88
AA V + +FP + K ++Q Q L + G V I++ +G L LW
Sbjct: 211 AAAVTQTLSFPFETVKRKMQAQSPY----LPHSGGVDVHFSGAVDCFRQIVKAQGVLGLW 266
Query: 89 QGVTPAIYRHVVYSGGRMVTYEHLREV 115
G+T + + V Y G T+E + +
Sbjct: 267 NGLTANLLKIVPYFGIMFSTFEFCKRI 293
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/281 (24%), Positives = 122/281 (43%), Gaps = 18/281 (6%)
Query: 39 PLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRH 98
P D+ K R Q+Q E L+R + SA Y G+++ + I++EEG W+G PA
Sbjct: 35 PFDVIKIRFQLQHER-LSR----SDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILS 89
Query: 99 VVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQME 158
+ Y + +++E L E+V S + + G +A + +P D+++ + +
Sbjct: 90 IGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ 149
Query: 159 GKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYL 218
G+ K+ + + HA + G + + G P + + Y ++KH
Sbjct: 150 GEPKV------YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLY 203
Query: 219 VLNTPLEDNIMTHGLSSLC---SGLVASILGTPADVIKSRI----MNQPRDKQGRGLLYK 271
P E + + LC +G+++ L P D+ K R+ R G+ YK
Sbjct: 204 KWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYK 263
Query: 272 SSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYE 312
DC Q +Q EG + +KG PS L+ + + +YE
Sbjct: 264 GLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 60.1 bits (144), Expect = 3e-09
Identities = 49/186 (26%), Positives = 87/186 (46%), Gaps = 19/186 (10%)
Query: 23 FLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALG-IIEE 81
F+ G AA +A L P+D+ +TR QGE + +R A+G +
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKV-------------YNTLRHAVGTMYRS 168
Query: 82 EGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFG--KSEDEHYPLWKSVIGGMMAGV 139
EG ++G+ P + Y+G + Y L+ + +E + ++++ G AGV
Sbjct: 169 EGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGV 228
Query: 140 IGQFLANPTDLVKVQMQMEG---KRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPN 196
I + L P DL K ++Q+ G R G+ R++G+ ++L + G G + G P+
Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288
Query: 197 IQRAAL 202
+ +AAL
Sbjct: 289 LLKAAL 294
Score = 55.1 bits (131), Expect = 8e-08
Identities = 44/207 (21%), Positives = 97/207 (46%), Gaps = 19/207 (9%)
Query: 119 KSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKP-LRFRGVHHAF 177
K + + ++ + G ++G++ + L +P D++K++ Q++ +R P ++ G+ A
Sbjct: 7 KPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQAS 66
Query: 178 AKILAEGGIRGLWAGWVPNIQRAALVNMG----DLTTYDTVKHYLVLNTPLEDNIMTHGL 233
+IL E G W G VP A ++++G +++ + LV + D +
Sbjct: 67 RQILQEEGPTAFWKGHVP----AQILSIGYGAVQFLSFEMLTE-LVHRGSVYD-AREFSV 120
Query: 234 SSLCSGL---VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLY 290
+C GL +A++ P DV+++R QG +Y + + + EG Y
Sbjct: 121 HFVCGGLAACMATLTVHPVDVLRTRFA-----AQGEPKVYNTLRHAVGTMYRSEGPQVFY 175
Query: 291 KGFLPSWLRMTPWSMVFWLTYEKIREM 317
KG P+ + + P++ + + Y ++ +
Sbjct: 176 KGLAPTLIAIFPYAGLQFSCYSSLKHL 202
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/281 (24%), Positives = 122/281 (43%), Gaps = 18/281 (6%)
Query: 39 PLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRH 98
P D+ K R Q+Q E L+R + SA Y G+++ + I++EEG W+G PA
Sbjct: 35 PFDVIKIRFQLQHER-LSR----SDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILS 89
Query: 99 VVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQME 158
+ Y + +++E L E+V S + + G +A + +P D+++ + +
Sbjct: 90 IGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ 149
Query: 159 GKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYL 218
G+ K+ + + HA + G + + G P + + Y ++KH
Sbjct: 150 GEPKV------YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLY 203
Query: 219 VLNTPLEDNIMTHGLSSLC---SGLVASILGTPADVIKSRI----MNQPRDKQGRGLLYK 271
P E + + LC +G+++ L P D+ K R+ R G+ YK
Sbjct: 204 KWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYK 263
Query: 272 SSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYE 312
DC Q +Q EG + +KG PS L+ + + +YE
Sbjct: 264 GLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 60.1 bits (144), Expect = 3e-09
Identities = 49/186 (26%), Positives = 87/186 (46%), Gaps = 19/186 (10%)
Query: 23 FLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALG-IIEE 81
F+ G AA +A L P+D+ +TR QGE + +R A+G +
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKV-------------YNTLRHAVGTMYRS 168
Query: 82 EGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFG--KSEDEHYPLWKSVIGGMMAGV 139
EG ++G+ P + Y+G + Y L+ + +E + ++++ G AGV
Sbjct: 169 EGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGV 228
Query: 140 IGQFLANPTDLVKVQMQMEG---KRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPN 196
I + L P DL K ++Q+ G R G+ R++G+ ++L + G G + G P+
Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288
Query: 197 IQRAAL 202
+ +AAL
Sbjct: 289 LLKAAL 294
Score = 55.1 bits (131), Expect = 8e-08
Identities = 44/207 (21%), Positives = 97/207 (46%), Gaps = 19/207 (9%)
Query: 119 KSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKP-LRFRGVHHAF 177
K + + ++ + G ++G++ + L +P D++K++ Q++ +R P ++ G+ A
Sbjct: 7 KPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQAS 66
Query: 178 AKILAEGGIRGLWAGWVPNIQRAALVNMG----DLTTYDTVKHYLVLNTPLEDNIMTHGL 233
+IL E G W G VP A ++++G +++ + LV + D +
Sbjct: 67 RQILQEEGPTAFWKGHVP----AQILSIGYGAVQFLSFEMLTE-LVHRGSVYD-AREFSV 120
Query: 234 SSLCSGL---VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLY 290
+C GL +A++ P DV+++R QG +Y + + + EG Y
Sbjct: 121 HFVCGGLAACMATLTVHPVDVLRTRFA-----AQGEPKVYNTLRHAVGTMYRSEGPQVFY 175
Query: 291 KGFLPSWLRMTPWSMVFWLTYEKIREM 317
KG P+ + + P++ + + Y ++ +
Sbjct: 176 KGLAPTLIAIFPYAGLQFSCYSSLKHL 202
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/281 (24%), Positives = 122/281 (43%), Gaps = 18/281 (6%)
Query: 39 PLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRH 98
P D+ K R Q+Q E L+R + SA Y G+++ + I++EEG W+G PA
Sbjct: 35 PFDVIKIRFQLQHER-LSR----SDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILS 89
Query: 99 VVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQME 158
+ Y + +++E L E+V S + + G +A + +P D+++ + +
Sbjct: 90 IGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ 149
Query: 159 GKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYL 218
G+ K+ + + HA + G + + G P + + Y ++KH
Sbjct: 150 GEPKV------YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLY 203
Query: 219 VLNTPLEDNIMTHGLSSLC---SGLVASILGTPADVIKSRI----MNQPRDKQGRGLLYK 271
P E + + LC +G+++ L P D+ K R+ R G+ YK
Sbjct: 204 KWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYK 263
Query: 272 SSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYE 312
DC Q +Q EG + +KG PS L+ + + +YE
Sbjct: 264 GLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 60.1 bits (144), Expect = 3e-09
Identities = 49/186 (26%), Positives = 87/186 (46%), Gaps = 19/186 (10%)
Query: 23 FLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALG-IIEE 81
F+ G AA +A L P+D+ +TR QGE + +R A+G +
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKV-------------YNTLRHAVGTMYRS 168
Query: 82 EGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFG--KSEDEHYPLWKSVIGGMMAGV 139
EG ++G+ P + Y+G + Y L+ + +E + ++++ G AGV
Sbjct: 169 EGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGV 228
Query: 140 IGQFLANPTDLVKVQMQMEG---KRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPN 196
I + L P DL K ++Q+ G R G+ R++G+ ++L + G G + G P+
Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288
Query: 197 IQRAAL 202
+ +AAL
Sbjct: 289 LLKAAL 294
Score = 55.1 bits (131), Expect = 8e-08
Identities = 44/207 (21%), Positives = 97/207 (46%), Gaps = 19/207 (9%)
Query: 119 KSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKP-LRFRGVHHAF 177
K + + ++ + G ++G++ + L +P D++K++ Q++ +R P ++ G+ A
Sbjct: 7 KPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQAS 66
Query: 178 AKILAEGGIRGLWAGWVPNIQRAALVNMG----DLTTYDTVKHYLVLNTPLEDNIMTHGL 233
+IL E G W G VP A ++++G +++ + LV + D +
Sbjct: 67 RQILQEEGPTAFWKGHVP----AQILSIGYGAVQFLSFEMLTE-LVHRGSVYD-AREFSV 120
Query: 234 SSLCSGL---VASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLY 290
+C GL +A++ P DV+++R QG +Y + + + EG Y
Sbjct: 121 HFVCGGLAACMATLTVHPVDVLRTRFA-----AQGEPKVYNTLRHAVGTMYRSEGPQVFY 175
Query: 291 KGFLPSWLRMTPWSMVFWLTYEKIREM 317
KG P+ + + P++ + + Y ++ +
Sbjct: 176 KGLAPTLIAIFPYAGLQFSCYSSLKHL 202
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 84.3 bits (207), Expect = 1e-16
Identities = 72/302 (23%), Positives = 127/302 (42%), Gaps = 19/302 (6%)
Query: 20 ASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGII 79
A FL G AA +++ A P++ K LQ+Q Y+G++ + I
Sbjct: 9 AKDFLAGGVAAAISKTAVAPIERVKLLLQVQ------HASKQITADKQYKGIIDCVVRIP 62
Query: 80 EEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIG----GM 135
+E+G L W+G + R+ + +++ G D+ W G G
Sbjct: 63 KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG-GVDKRTQFWLYFAGNLASGG 121
Query: 136 MAGVIGQFLANPTDLVKVQMQME-GKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWV 194
AG P D + ++ + GK G FRG+ KI GI+GL+ G+
Sbjct: 122 AAGATSLCFVYPLDFARTRLAADVGKA---GAEREFRGLGDCLVKIYKSDGIKGLYQGFN 178
Query: 195 PNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKS 254
++Q + YDT K +L P +I+ + + VA + P D ++
Sbjct: 179 VSVQGIIIYRAAYFGIYDTAKG--MLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRR 236
Query: 255 RIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKI 314
R+M Q ++G ++Y + DC + + EG + +KG + LR + V L Y++I
Sbjct: 237 RMMMQ-SGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVL-YDEI 294
Query: 315 RE 316
++
Sbjct: 295 KK 296
Score = 30.4 bits (67), Expect = 2.2
Identities = 22/98 (22%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 224 LEDNIMTHGLSSLCSGLVASILGT---PADVIKSRIMNQPRDKQ-GRGLLYKSSTDCLIQ 279
+ D ++ L G+ A+I T P + +K + Q KQ YK DC+++
Sbjct: 1 MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVR 60
Query: 280 AVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREM 317
+ +G +S ++G L + +R P + + +K +++
Sbjct: 61 IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQI 98
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 81.6 bits (200), Expect = 8e-16
Identities = 74/327 (22%), Positives = 143/327 (43%), Gaps = 35/327 (10%)
Query: 1 MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAA--LARL 58
++VP+E + LT W + + + A V+ T PLD K +Q+ L L
Sbjct: 169 LTVPDEFSKQEKLTGMWWK--QLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNIL 226
Query: 59 GDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFG 118
G G R ++ E G LW+G + + S + + YE ++ + G
Sbjct: 227 G-GLRS-------------MVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILG 272
Query: 119 KSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFA 178
+ E H + + + G +AG Q + P +++K ++ + + +++G+
Sbjct: 273 QQETLH--VQERFVAGSLAGATAQTIIYPMEVLKTRLTLR-------RTGQYKGLLDCAR 323
Query: 179 KILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCS 238
+IL G R + G++PN+ DL Y+T+K++ L D+ L L
Sbjct: 324 RILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWW-LQQYSHDSADPGILVLLAC 382
Query: 239 GLVASILGT----PADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFL 294
G ++S G P ++++R+ Q + G L S L + EG LY+G
Sbjct: 383 GTISSTCGQIASYPLALVRTRMQAQASIEGGPQL---SMLGLLRHILSQEGMRGLYRGIA 439
Query: 295 PSWLRMTPWSMVFWLTYEKIREMSGVS 321
P+++++ P + ++ YE +++ GV+
Sbjct: 440 PNFMKVIPAVSISYVVYENMKQALGVT 466
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 80.5 bits (197), Expect = 2e-15
Identities = 72/325 (22%), Positives = 143/325 (44%), Gaps = 31/325 (9%)
Query: 1 MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGD 60
+++P+E + +W R + L G A V+ +T PLD K +Q+ G + D
Sbjct: 178 LTIPDEFTEDEKKSGQWWR--QLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKS-----D 230
Query: 61 GARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS 120
+R MV+ E G LW+G + + + + YE ++++
Sbjct: 231 KMNIFGGFRQMVK-------EGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLL--TE 281
Query: 121 EDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKI 180
E + ++ I G MAG Q P +++K ++ + GK ++ G++ KI
Sbjct: 282 EGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV-------GKTGQYSGIYDCAKKI 334
Query: 181 LAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGL 240
L G+ + G+VPN+ DL Y+ +K Y + N +D++ + L G
Sbjct: 335 LKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFA-KDSVNPGVMVLLGCGA 393
Query: 241 VASILGT----PADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPS 296
++S G P ++++R+ Q + L + + + EG LY+G P+
Sbjct: 394 LSSTCGQLASYPLALVRTRMQAQAMLEGSPQL---NMVGLFRRIISKEGIPGLYRGITPN 450
Query: 297 WLRMTPWSMVFWLTYEKIREMSGVS 321
++++ P + ++ YE +++ GV+
Sbjct: 451 FMKVLPAVGISYVVYENMKQTLGVT 475
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 80.5 bits (197), Expect = 2e-15
Identities = 72/325 (22%), Positives = 143/325 (44%), Gaps = 31/325 (9%)
Query: 1 MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGD 60
+++P+E + +W R + L G A V+ +T PLD K +Q+ G + D
Sbjct: 159 LTIPDEFTEDEKKSGQWWR--QLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKS-----D 211
Query: 61 GARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS 120
+R MV+ E G LW+G + + + + YE ++++
Sbjct: 212 KMNIFGGFRQMVK-------EGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLL--TE 262
Query: 121 EDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKI 180
E + ++ I G MAG Q P +++K ++ + GK ++ G++ KI
Sbjct: 263 EGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV-------GKTGQYSGIYDCAKKI 315
Query: 181 LAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGL 240
L G+ + G+VPN+ DL Y+ +K Y + N +D++ + L G
Sbjct: 316 LKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFA-KDSVNPGVMVLLGCGA 374
Query: 241 VASILGT----PADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPS 296
++S G P ++++R+ Q + L + + + EG LY+G P+
Sbjct: 375 LSSTCGQLASYPLALVRTRMQAQAMLEGSPQL---NMVGLFRRIISKEGIPGLYRGITPN 431
Query: 297 WLRMTPWSMVFWLTYEKIREMSGVS 321
++++ P + ++ YE +++ GV+
Sbjct: 432 FMKVLPAVGISYVVYENMKQTLGVT 456
>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
Length = 318
Score = 79.0 bits (193), Expect = 5e-15
Identities = 72/286 (25%), Positives = 118/286 (41%), Gaps = 33/286 (11%)
Query: 21 SKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIE 80
S L A +A+ A PLD TK Q+ + A+ +R + T L
Sbjct: 35 SSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAK--------EAFRVLYYTYLN--- 83
Query: 81 EEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVV--FGKSEDEHYPLWKSVIGGMMAG 138
EGFL LW+G + + R V Y+ + +E + ++ + E P W + G +AG
Sbjct: 84 -EGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAG 142
Query: 139 VIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQ 198
L P DLV+ +M + K + + H F +I E G++ L+ G++P +
Sbjct: 143 TTAASLTYPLDLVRARMAVTPKE-------MYSNIFHVFIRISREEGLKTLYHGFMPTVL 195
Query: 199 RAALVNMGDLTTYDTVK----HYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKS 254
TY+T+K Y P M G C+GL+ P DV++
Sbjct: 196 GVIPYAGLSFFTYETLKSLHREYSGRRQPYPFERMIFG---ACAGLIGQSASYPLDVVRR 252
Query: 255 RIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFM-SLYKGFLPSWLR 299
R+ R + ++ L V+ EG + LYKG +W++
Sbjct: 253 RMQTAGVTGYPRASIART----LRTIVREEGAVRGLYKGLSMNWVK 294
Score = 62.8 bits (151), Expect = 4e-10
Identities = 56/200 (28%), Positives = 88/200 (44%), Gaps = 22/200 (11%)
Query: 17 WPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTAL 76
WPR L+G T A T+PLDL + R+ + + Y + +
Sbjct: 132 WPRLFAGALAG---TTAASLTYPLDLVRARMAVTPKEM-------------YSNIFHVFI 175
Query: 77 GIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKS-EDEHYPLWKSVIGGM 135
I EEG L+ G P + + Y+G TYE L+ + S + YP ++ +I G
Sbjct: 176 RISREEGLKTLYHGFMPTVLGVIPYAGLSFFTYETLKSLHREYSGRRQPYP-FERMIFGA 234
Query: 136 MAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVP 195
AG+IGQ + P D+V+ +MQ G + G P R + EG +RGL+ G
Sbjct: 235 CAGLIGQSASYPLDVVRRRMQTAG---VTGYP-RASIARTLRTIVREEGAVRGLYKGLSM 290
Query: 196 NIQRAALVNMGDLTTYDTVK 215
N + + TT+D ++
Sbjct: 291 NWVKGPIAVGISFTTFDLMQ 310
Score = 53.1 bits (126), Expect = 3e-07
Identities = 42/201 (20%), Positives = 87/201 (43%), Gaps = 15/201 (7%)
Query: 120 SEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAK 179
S+ +H + S++ G +AG + + P D K+ Q+ KR + FR +++ +
Sbjct: 26 SKRDHRQVLSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEA--FRVLYYTYLN 83
Query: 180 ILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHG---LSSL 236
G LW G + R + ++ K L + +
Sbjct: 84 ----EGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGA 139
Query: 237 CSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPS 296
+G A+ L P D++++R+ P++ +Y + I+ + EG +LY GF+P+
Sbjct: 140 LAGTTAASLTYPLDLVRARMAVTPKE------MYSNIFHVFIRISREEGLKTLYHGFMPT 193
Query: 297 WLRMTPWSMVFWLTYEKIREM 317
L + P++ + + TYE ++ +
Sbjct: 194 VLGVIPYAGLSFFTYETLKSL 214
Score = 31.6 bits (70), Expect = 1.00
Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 233 LSSLCSGLVASILGTPA--DVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLY 290
LSSL G +A L A + +++I+ Q K+ K + L EGF+SL+
Sbjct: 34 LSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSA---KEAFRVLYYTYLNEGFLSLW 90
Query: 291 KGFLPSWLRMTPWSMVFWLTYEKIREMSG 319
+G + +R+ P++ + + +E+ + + G
Sbjct: 91 RGNSATMVRVVPYAAIQFSAHEEYKRILG 119
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 77.0 bits (188), Expect = 2e-14
Identities = 77/300 (25%), Positives = 123/300 (41%), Gaps = 28/300 (9%)
Query: 20 ASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGII 79
A +F L A V A +P+DL KTR+Q Q R Y+ ++
Sbjct: 327 AYRFTLGSVAGAVGATAVYPIDLVKTRMQNQ------RGSGSVVGELMYKNSFDCFKKVL 380
Query: 80 EEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGV 139
EGF L++G+ P + ++ + +R+ D PL V+ G AG
Sbjct: 381 RYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKF--TRRDGSVPLPAEVLAGGCAGG 438
Query: 140 IGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQR 199
NP ++VK+++Q+ G+ G + +L + GI GL+ G R
Sbjct: 439 SQVIFTNPLEIVKIRLQVAGEIT--------TGPRVSALNVLRDLGIFGLYKGAKACFLR 490
Query: 200 AALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASI----LGTPADVIKSR 255
+ Y K L ++N GL+ L +G +A + L TPADVIK+R
Sbjct: 491 DIPFSAIYFPVYAHCKLLLA-----DENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTR 545
Query: 256 IMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIR 315
+ R Q Y DC + ++ EG + +KG R +P V +TYE ++
Sbjct: 546 LQVAARAGQ---TTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQ 602
Score = 67.8 bits (164), Expect = 1e-11
Identities = 52/204 (25%), Positives = 87/204 (42%), Gaps = 20/204 (9%)
Query: 18 PRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALG 77
P ++ L GCA + T PL++ K RLQ+ GE + G R S AL
Sbjct: 425 PLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGE-----ITTGPRVS---------ALN 470
Query: 78 IIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMA 137
++ + G L++G R + +S Y H + ++ E+ H + G MA
Sbjct: 471 VLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLL--ADENGHVGGLNLLAAGAMA 528
Query: 138 GVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNI 197
GV L P D++K ++Q+ + + GV F KIL E G W G +
Sbjct: 529 GVPAASLVTPADVIKTRLQVAAR----AGQTTYSGVIDCFRKILREEGPSAFWKGTAARV 584
Query: 198 QRAALVNMGDLTTYDTVKHYLVLN 221
R++ L TY+ ++ + ++
Sbjct: 585 FRSSPQFGVTLVTYELLQRWFYID 608
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 77.0 bits (188), Expect = 2e-14
Identities = 79/329 (24%), Positives = 143/329 (43%), Gaps = 41/329 (12%)
Query: 1 MSVPEE---EERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALAR 57
++VP+E EER T W R + G A V+ T PLD K +Q+ +
Sbjct: 170 LTVPDEFTVEERQ---TGMWWR--HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRS--- 221
Query: 58 LGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVF 117
G+V +I E G LW+G + + S + + YE ++ +V
Sbjct: 222 ---------NNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV- 271
Query: 118 GKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAF 177
S+ E + + ++ G +AG I Q P +++K +M + K ++ G+
Sbjct: 272 -GSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR-------KTGQYSGMLDCA 323
Query: 178 AKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVK-----HYLVLNT-PLEDNIMTH 231
+ILA G+ + G+VPN+ DL Y+T+K HY V + P ++
Sbjct: 324 RRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLAC 383
Query: 232 GLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYK 291
G S G +AS P ++++R+ Q + + S +++ EG LY+
Sbjct: 384 GTMSSTCGQLASY---PLALVRTRMQAQASIEGAPEVTMSSLFKHILRT---EGAFGLYR 437
Query: 292 GFLPSWLRMTPWSMVFWLTYEKIREMSGV 320
G P+++++ P + ++ YE ++ GV
Sbjct: 438 GLAPNFMKVIPAVSISYVVYENLKITLGV 466
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 77.0 bits (188), Expect = 2e-14
Identities = 79/329 (24%), Positives = 143/329 (43%), Gaps = 41/329 (12%)
Query: 1 MSVPEE---EERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALAR 57
++VP+E EER T W R + G A V+ T PLD K +Q+ +
Sbjct: 204 LTVPDEFTVEERQ---TGMWWR--HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRS--- 255
Query: 58 LGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVF 117
G+V +I E G LW+G + + S + + YE ++ +V
Sbjct: 256 ---------NNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV- 305
Query: 118 GKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAF 177
S+ E + + ++ G +AG I Q P +++K +M + K ++ G+
Sbjct: 306 -GSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR-------KTGQYSGMLDCA 357
Query: 178 AKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVK-----HYLVLNT-PLEDNIMTH 231
+ILA G+ + G+VPN+ DL Y+T+K HY V + P ++
Sbjct: 358 RRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLAC 417
Query: 232 GLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYK 291
G S G +AS P ++++R+ Q + + S +++ EG LY+
Sbjct: 418 GTMSSTCGQLASY---PLALVRTRMQAQASIEGAPEVTMSSLFKHILRT---EGAFGLYR 471
Query: 292 GFLPSWLRMTPWSMVFWLTYEKIREMSGV 320
G P+++++ P + ++ YE ++ GV
Sbjct: 472 GLAPNFMKVIPAVSISYVVYENLKITLGV 500
>gi|46094065 mitochondrial carrier family protein [Homo sapiens]
Length = 338
Score = 77.0 bits (188), Expect = 2e-14
Identities = 70/314 (22%), Positives = 127/314 (40%), Gaps = 35/314 (11%)
Query: 24 LLSGCA-ATVAELATFPLDLTKTRLQMQGEAA---------------LARLGDGA----- 62
+L+ C A + + PLD+ K RLQ Q L +G
Sbjct: 19 MLASCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNGLMDHLCVCEEGGNKLWY 78
Query: 63 RESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSED 122
++ ++G + II EG LW G+ P + V + Y+ L ++ K +
Sbjct: 79 KKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALLRSKLGE 138
Query: 123 EHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILA 182
+ ++ G++A + +P +L++ +MQ K + +H +K ++
Sbjct: 139 NETCI--PIVAGIVARFGAVTVISPLELIRTKMQ--------SKKFSYVELHRFVSKKVS 188
Query: 183 EGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPL-EDNIMTHGLSSLCSGLV 241
E G LW GW P + R + Y+ +K +L + L E M + S SG
Sbjct: 189 EDGWISLWRGWAPTVLRDVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSF 248
Query: 242 ASILGTPADVIKSRIMNQPRDKQGRGL---LYKSSTDCLIQAVQGEGFMSLYKGFLPSWL 298
A++ P DV+K++ Q + + L+ S+ + V GF L+ G +P +
Sbjct: 249 AAVATLPFDVVKTQKQTQLWTYESHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLI 308
Query: 299 RMTPWSMVFWLTYE 312
++ P + TYE
Sbjct: 309 KIAPACAIMISTYE 322
Score = 62.0 bits (149), Expect = 7e-10
Identities = 51/222 (22%), Positives = 96/222 (43%), Gaps = 50/222 (22%)
Query: 129 KSVIGGMMAGVIGQFLANPTDLVKVQMQM-------------------------EGKRKL 163
+ ++ ++ + P D+VK+++Q EG KL
Sbjct: 17 QQMLASCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNGLMDHLCVCEEGGNKL 76
Query: 164 -EGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNT 222
KP F+G AF KI+ GI+ LW+G P + A + T YD + +L +
Sbjct: 77 WYKKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLS--ALLRS 134
Query: 223 PLEDNIMTHGLSSLCSGLVASILG--------TPADVIKSRIMNQPRDKQGRGLLYKSST 274
L +N C +VA I+ +P ++I++++ Q + Y
Sbjct: 135 KLGEN-------ETCIPIVAGIVARFGAVTVISPLELIRTKM-------QSKKFSYVELH 180
Query: 275 DCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIRE 316
+ + V +G++SL++G+ P+ LR P+S ++W YE +++
Sbjct: 181 RFVSKKVSEDGWISLWRGWAPTVLRDVPFSAMYWYNYEILKK 222
Score = 47.4 bits (111), Expect = 2e-05
Identities = 43/183 (23%), Positives = 76/183 (41%), Gaps = 20/183 (10%)
Query: 39 PLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRH 98
PL+L +T++Q + Y + R + E+G++ LW+G P + R
Sbjct: 161 PLELIRTKMQSK--------------KFSYVELHRFVSKKVSEDGWISLWRGWAPTVLRD 206
Query: 99 VVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQME 158
V +S YE L++ + KS + G ++G P D+VK Q Q +
Sbjct: 207 VPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQ 266
Query: 159 ----GKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTV 214
K+ PL I+A+ G GL++G +P + + A ++TY+
Sbjct: 267 LWTYESHKI-SMPLHM-STWIIMKNIVAKNGFSGLFSGLIPRLIKIAPACAIMISTYEFG 324
Query: 215 KHY 217
K +
Sbjct: 325 KAF 327
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 77.0 bits (188), Expect = 2e-14
Identities = 79/329 (24%), Positives = 143/329 (43%), Gaps = 41/329 (12%)
Query: 1 MSVPEE---EERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALAR 57
++VP+E EER T W R + G A V+ T PLD K +Q+ +
Sbjct: 190 LTVPDEFTVEERQ---TGMWWR--HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRS--- 241
Query: 58 LGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVF 117
G+V +I E G LW+G + + S + + YE ++ +V
Sbjct: 242 ---------NNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLV- 291
Query: 118 GKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAF 177
S+ E + + ++ G +AG I Q P +++K +M + K ++ G+
Sbjct: 292 -GSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR-------KTGQYSGMLDCA 343
Query: 178 AKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVK-----HYLVLNT-PLEDNIMTH 231
+ILA G+ + G+VPN+ DL Y+T+K HY V + P ++
Sbjct: 344 RRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLAC 403
Query: 232 GLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYK 291
G S G +AS P ++++R+ Q + + S +++ EG LY+
Sbjct: 404 GTMSSTCGQLASY---PLALVRTRMQAQASIEGAPEVTMSSLFKHILRT---EGAFGLYR 457
Query: 292 GFLPSWLRMTPWSMVFWLTYEKIREMSGV 320
G P+++++ P + ++ YE ++ GV
Sbjct: 458 GLAPNFMKVIPAVSISYVVYENLKITLGV 486
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,975,710
Number of Sequences: 37866
Number of extensions: 499027
Number of successful extensions: 1500
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 883
Number of HSP's gapped (non-prelim): 205
length of query: 323
length of database: 18,247,518
effective HSP length: 102
effective length of query: 221
effective length of database: 14,385,186
effective search space: 3179126106
effective search space used: 3179126106
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.