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Search of human proteins with 4506401
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1
[Homo sapiens]
(648 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 1319 0.0
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 724 0.0
gi|33188459 B-Raf [Homo sapiens] 694 0.0
gi|75677325 kinase suppressor of ras [Homo sapiens] 181 1e-45
gi|167621456 kinase suppressor of ras 2 [Homo sapiens] 179 7e-45
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 152 9e-37
gi|4503787 fyn-related kinase [Homo sapiens] 150 4e-36
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 150 5e-36
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 150 5e-36
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 149 8e-36
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 147 3e-35
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 144 3e-34
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 142 1e-33
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 142 1e-33
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi... 141 2e-33
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 139 8e-33
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 139 8e-33
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 139 8e-33
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 139 1e-32
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 139 1e-32
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 139 1e-32
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 138 2e-32
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 137 2e-32
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 137 2e-32
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 136 5e-32
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 136 5e-32
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 136 5e-32
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 136 7e-32
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 135 1e-31
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 134 3e-31
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 1319 bits (3413), Expect = 0.0
Identities = 648/648 (100%), Positives = 648/648 (100%)
Query: 1 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV 60
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
Sbjct: 1 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV 60
Query: 61 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS 120
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
Sbjct: 61 FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS 120
Query: 121 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV 180
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
Sbjct: 121 LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV 180
Query: 181 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF 240
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
Sbjct: 181 PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF 240
Query: 241 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL 300
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
Sbjct: 241 NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL 300
Query: 301 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF 360
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
Sbjct: 301 SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF 360
Query: 361 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV 420
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
Sbjct: 361 GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV 420
Query: 421 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL 480
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
Sbjct: 421 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL 480
Query: 481 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE 540
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
Sbjct: 481 TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE 540
Query: 541 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP 600
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
Sbjct: 541 LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP 600
Query: 601 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF 648
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Sbjct: 601 QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF 648
>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
sapiens]
Length = 606
Score = 724 bits (1869), Expect = 0.0
Identities = 376/607 (61%), Positives = 452/607 (74%), Gaps = 23/607 (3%)
Query: 50 DPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKK 109
+PS+ T++V+LPNKQRTVV VR+GMS++D L KALKVRGL +CC V+RL+ KG+K
Sbjct: 13 EPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLI---KGRK 69
Query: 110 ARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCG 169
W+T A L GEEL V+ L+ VPLT HNF RKTF LAFCD C KFL +GFRCQTCG
Sbjct: 70 TVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCG 129
Query: 170 YKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTI-GDSGVPALPSLTMRRMRESVSRMPVSS 228
YKFH+HCS+KVPT+CVD S RQ + G S PS R + E ++ S
Sbjct: 130 YKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPS--NRPLNELLTPQGPSP 187
Query: 229 QHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIE--------DA 280
+ ++ P F F P+ + QR RSTSTPNVHMVSTT P+DS +I+ DA
Sbjct: 188 RTQHCDPEHFPF----PAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDA 243
Query: 281 IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPA-QRERAPVSGTQEKNKIRPRGQRDSS 339
S S S SP ++S +G P + PA QRER ++ +K K++ G RDS
Sbjct: 244 AGSRGGSDGTPRGSPSPASVS-SGRKSPHSKSPAEQRERKSLA--DDKKKVKNLGYRDSG 300
Query: 340 YYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRK 399
YYWE+ SEV L RIG+GSFGTV++G+WHGDVAVK+LKV PT EQ QAF+NE+ VLRK
Sbjct: 301 YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK 360
Query: 400 TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
TRHVNILLFMG+MT+ AI+TQWCEGSSLY HLHV +T+F M QLID+ARQTAQGMDYL
Sbjct: 361 TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL 420
Query: 460 HAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRM 519
HAKNIIHRD+KSNNIFLHEGLTVKIGDFGLATVK+RWSG+Q +EQP+GSVLWMA EVIRM
Sbjct: 421 HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM 480
Query: 520 QDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 579
QD NP+SFQSDVY+YG+VLYELMTG LPYSHI RDQIIFMVGRGY SPDLSK+ NCPK
Sbjct: 481 QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 540
Query: 580 AMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTL 639
AM+RL++DC+K +EERPLFPQIL++IELLQ SLPKI RSASEPSLHR +++ AC L
Sbjct: 541 AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHR-TQADELPACLL 599
Query: 640 TTSPRLP 646
+ + +P
Sbjct: 600 SAARLVP 606
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 694 bits (1791), Expect = 0.0
Identities = 379/668 (56%), Positives = 459/668 (68%), Gaps = 42/668 (6%)
Query: 9 KTISNGFGFK-------DAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVF 61
+++ NG F D V SS + + +D + S +RVF
Sbjct: 101 ESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVF 160
Query: 62 LPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASL 121
LPNKQRTVV R G+++ D L KAL +RGL PECCAV+R+ G+K + W+TD + L
Sbjct: 161 LPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRI---QDGEKKPIGWDTDISWL 217
Query: 122 IGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVP 181
GEEL V+ L++VPLTTHNF RKTF LAFCD C+K L GFRCQTCGYKFH+ CST+VP
Sbjct: 218 TGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVP 277
Query: 182 TMCVDWSNIRQLLLFPNSTIGDSGVP---------ALPSLTMRRMRESVSRMP---VSSQ 229
MCV++ + LLF + +P AL S + S S P S
Sbjct: 278 LMCVNYDQLD--LLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPS 335
Query: 230 HRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHS---E 286
S P F + QR RS+S PNVH ++T PV+ I+D IR +
Sbjct: 336 PSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVH-INTIEPVN---IDDLIRDQGFRGD 391
Query: 287 SASPSALSSSPNNLSPTGWSQ----PKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYW 342
S + LS++P P + K+P P QRER S ++++N+++ G+RDSS W
Sbjct: 392 GGSTTGLSATPPASLPGSLTNVKALQKSPGP-QRERKSSSSSEDRNRMKTLGRRDSSDDW 450
Query: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRH 402
EI ++ + RIGSGSFGTVYKGKWHGDVAVK+L V PTP+Q QAF+NEV VLRKTRH
Sbjct: 451 EIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRH 510
Query: 403 VNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 462
VNILLFMGY TK LAIVTQWCEGSSLY HLH+ ETKF+M +LIDIARQTAQGMDYLHAK
Sbjct: 511 VNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 570
Query: 463 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDN 522
+IIHRD+KSNNIFLHE LTVKIGDFGLATVKSRWSGS Q EQ +GS+LWMAPEVIRMQD
Sbjct: 571 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 630
Query: 523 NPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMK 582
NP+SFQSDVY++GIVLYELMTG+LPYS+INNRDQIIFMVGRGY SPDLSK+ NCPKAMK
Sbjct: 631 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 690
Query: 583 RLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAA-HTEDIN--ACTL 639
RL+A+C+KK ++ERPLFPQIL+SIELL SLPKI+RSASEPSL+RA TED + AC
Sbjct: 691 RLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYAC-- 748
Query: 640 TTSPRLPV 647
SP+ P+
Sbjct: 749 -ASPKTPI 755
>gi|75677325 kinase suppressor of ras [Homo sapiens]
Length = 762
Score = 181 bits (460), Expect = 1e-45
Identities = 145/551 (26%), Positives = 248/551 (45%), Gaps = 72/551 (13%)
Query: 138 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDW---SNIRQLL 194
TH F+ K++L C +CQK ++ G +C+ C K H C+ + P + + + +R+
Sbjct: 210 THRFSTKSWLSQV-CHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTE 268
Query: 195 LFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSL--- 251
P+ A P + P + H S+ + + +S+PSS
Sbjct: 269 SVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTS 328
Query: 252 SQRQRSTSTPNV------------------HMVSTTLPVDSR-------MIEDAIRSHSE 286
S +T+ PN H PV S +I ++++ ++
Sbjct: 329 SNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAF 388
Query: 287 SASPSALSSS-PNNLSPTGWS-QPKTPVPAQRE---RAPVSGTQE--------------- 326
+ S A ++ P T QPK V E P +G E
Sbjct: 389 NISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSR 448
Query: 327 ---KNKIRPRGQRDSSYY--WEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVD 381
+ I + + S Y W+I +V L IG G +G V++G+WHG+VA+++L++
Sbjct: 449 RPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDG 508
Query: 382 PTPEQFQAFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIVTQWCEGSSLYKHLHVQETKF 440
+ + F+ EV R+TRH N++LFMG M +LAI+T +C+G +L+ + +T
Sbjct: 509 HNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSL 568
Query: 441 QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTV--KIGDFGLATVKSRWSG 498
+ + IA++ +GM YLHAK I+H+D+KS N+F G V G FG++ V
Sbjct: 569 DINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRR 628
Query: 499 SQQVEQPTGSVLWMAPEVIRM------QDNNPFSFQSDVYSYGIVLYELMTGELPYSHIN 552
Q++ + ++APE++R +D PFS +DVY++G V YEL + P +
Sbjct: 629 ENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKN-Q 687
Query: 553 NRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS 612
+ I+ +G G + + K + +++ C +ERP F ++ +E
Sbjct: 688 AAEASIWQIGSGEGMKRVLTSV-SLGKEVSEILSACWAFDLQERPSFSLLMDMLE----K 742
Query: 613 LPKINRSASEP 623
LPK+NR S P
Sbjct: 743 LPKLNRRLSHP 753
>gi|167621456 kinase suppressor of ras 2 [Homo sapiens]
Length = 921
Score = 179 bits (454), Expect = 7e-45
Identities = 159/572 (27%), Positives = 244/572 (42%), Gaps = 130/572 (22%)
Query: 139 HNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPN 198
H F+ K ++ C +C K +L G +C+ C K H C+ + P LL+
Sbjct: 384 HRFSTKYWMSQT-CTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPC--------HLLIIHR 434
Query: 199 STIGDSGVPALPSLTMRRMRESVS---RMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQ 255
GD P+ +R ESV P+ RYS H +SQ
Sbjct: 435 ---GD------PARLVRT--ESVPCDINNPLRKPPRYSDLH--------------ISQTL 469
Query: 256 RSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESAS-----PSALSSSPNNLSPTGWSQPKT 310
T+ N + DS + S + S+ PSA SP + SP Q K
Sbjct: 470 PKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKN 529
Query: 311 ---------------------PVPAQRERAP----------------------VSGTQEK 327
PVP RAP V T E
Sbjct: 530 FNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSEN 589
Query: 328 NKIR-----------------------PRGQRDSSYY---WEIEASEVMLSTRIGSGSFG 361
++ PR +S + W+I ++ + IG G FG
Sbjct: 590 EEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFG 649
Query: 362 TVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIV 420
VY G+WHG+VA++++ + +Q +AF+ EV R+TRH N++LFMG M+ +LAI+
Sbjct: 650 QVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAII 709
Query: 421 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL 480
T C+G +LY + + + + IA++ +GM YLHAK I+H+D+KS N+F G
Sbjct: 710 TSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGK 769
Query: 481 TVKIGDFGLATVKSRWSGSQQVEQ---PTGSVLWMAPEVIRM------QDNNPFSFQSDV 531
V I DFGL ++ ++ ++ G + +APE+IR +D PFS SDV
Sbjct: 770 VV-ITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDV 828
Query: 532 YSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKK 591
++ G + YEL E P+ + II+ +G G P+LS++ K + ++ C
Sbjct: 829 FALGTIWYELHAREWPFK-TQPAEAIIWQMGTG-MKPNLSQI--GMGKEISDILLFCWAF 884
Query: 592 VKEERPLFPQILSSIELLQHSLPKINRSASEP 623
+EERP F +++ +E LPK NR S P
Sbjct: 885 EQEERPTFTKLMDMLE----KLPKRNRRLSHP 912
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 152 bits (384), Expect = 9e-37
Identities = 97/272 (35%), Positives = 152/272 (55%), Gaps = 20/272 (7%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WEI + L R+G+G FG V+ G W+G+ VA+K LK +PE +F E +++K
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---SFLEEAQIMKK 320
Query: 400 TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDIARQTAQGMDY 458
+H ++ ++++ + IVT++ SL L E + ++ L+D+A Q A GM Y
Sbjct: 321 LKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 380
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWMAPEV 516
+ N IHRD++S NI + GL KI DFGLA + + ++ Q + P + W APE
Sbjct: 381 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFP---IKWTAPEA 437
Query: 517 IRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYK 575
F+ +SDV+S+GI+L EL+T G +PY +NNR +++ V RGY P +
Sbjct: 438 ALY---GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR-EVLEQVERGYRMP----CPQ 489
Query: 576 NCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
+CP ++ L+ C KK EERP F + S +E
Sbjct: 490 DCPISLHELMIHCWKKDPEERPTFEYLQSFLE 521
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 150 bits (379), Expect = 4e-36
Identities = 100/293 (34%), Positives = 155/293 (52%), Gaps = 28/293 (9%)
Query: 329 KIRPRGQRDSSY----YWEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDP 382
KI+ D SY WEI+ + + L R+GSG FG V++G W+ VAVK LK
Sbjct: 210 KIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSM 269
Query: 383 TPEQFQAFRNEVAVLRKTRHVNILLFMGYMT-KDNLAIVTQWCEGSSLYKHLHVQE-TKF 440
P F E +++ RH ++ T +D + I+T+ SL ++L +K
Sbjct: 270 DPNDFL---REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKI 326
Query: 441 QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV-----KSR 495
+ Q +D+A Q A GM YL ++N IHRD+ + N+ + E K+ DFGLA V +
Sbjct: 327 HLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDI 386
Query: 496 WSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNR 554
+ +++ P V W APE IR +N FS +SDV+S+GI+LYE++T G++PYS +
Sbjct: 387 YESRHEIKLP---VKWTAPEAIR---SNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGA 440
Query: 555 DQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
Q+I M+ + Y P S NCP+ ++ +C +ERP F + +E
Sbjct: 441 -QVIQMLAQNYRLPQPS----NCPQQFYNIMLECWNAEPKERPTFETLRWKLE 488
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 150 bits (378), Expect = 5e-36
Identities = 96/283 (33%), Positives = 154/283 (54%), Gaps = 20/283 (7%)
Query: 331 RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQ 388
+P+ Q + WEI + L ++G G FG V+ G W+G VA+K LK +PE
Sbjct: 252 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE--- 308
Query: 389 AFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKF-QMFQLID 447
AF E V++K RH ++ ++++ + IVT++ SL L + K+ ++ QL+D
Sbjct: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368
Query: 448 IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQP 505
+A Q A GM Y+ N +HRD+++ NI + E L K+ DFGLA + + ++ Q + P
Sbjct: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428
Query: 506 TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRG 564
+ W APE F+ +SDV+S+GI+L EL T G +PY + NR +++ V RG
Sbjct: 429 ---IKWTAPEAALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERG 481
Query: 565 YASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
Y P CP+++ L+ C +K EERP F + + +E
Sbjct: 482 YRMP----CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 150 bits (378), Expect = 5e-36
Identities = 96/283 (33%), Positives = 154/283 (54%), Gaps = 20/283 (7%)
Query: 331 RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQ 388
+P+ Q + WEI + L ++G G FG V+ G W+G VA+K LK +PE
Sbjct: 252 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE--- 308
Query: 389 AFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKF-QMFQLID 447
AF E V++K RH ++ ++++ + IVT++ SL L + K+ ++ QL+D
Sbjct: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368
Query: 448 IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQP 505
+A Q A GM Y+ N +HRD+++ NI + E L K+ DFGLA + + ++ Q + P
Sbjct: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428
Query: 506 TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRG 564
+ W APE F+ +SDV+S+GI+L EL T G +PY + NR +++ V RG
Sbjct: 429 ---IKWTAPEAALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERG 481
Query: 565 YASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
Y P CP+++ L+ C +K EERP F + + +E
Sbjct: 482 YRMP----CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 149 bits (376), Expect = 8e-36
Identities = 98/284 (34%), Positives = 155/284 (54%), Gaps = 20/284 (7%)
Query: 330 IRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQF 387
++P+ Q + WEI + L ++G G FG V+ G W+G VA+K LK PE
Sbjct: 258 VKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPE-- 315
Query: 388 QAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKF-QMFQLI 446
AF E +++K RH ++ ++++ + IVT++ SL L + K+ ++ QL+
Sbjct: 316 -AFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLV 374
Query: 447 DIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQ 504
D+A Q A GM Y+ N IHRD+++ NI + E L KI DFGLA + + ++ Q +
Sbjct: 375 DMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKF 434
Query: 505 PTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGR 563
P + W APE F+ +SDV+S+GI+ EL+T G +PY + NR +++ V R
Sbjct: 435 P---IKWTAPEAALY---GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNR-EVLEQVER 487
Query: 564 GYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
GY P + CP+++ L+ C KK +ERP F I S +E
Sbjct: 488 GYRMP----CPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 527
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 147 bits (371), Expect = 3e-35
Identities = 94/272 (34%), Positives = 150/272 (55%), Gaps = 20/272 (7%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WE+ + L ++G G F V+ G W+G+ VA+K LK +PE +F E +++K
Sbjct: 261 WEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPE---SFLEEAQIMKK 317
Query: 400 TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDIARQTAQGMDY 458
+H ++ ++++ + IVT++ SL L E + ++ L+D+A Q A GM Y
Sbjct: 318 LKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 377
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWMAPEV 516
+ N IHRD++S NI + GL KI DFGLA + + ++ Q + P + W APE
Sbjct: 378 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFP---IKWTAPEA 434
Query: 517 IRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYK 575
F+ +SDV+S+GI+L EL+T G +PY +NNR +++ V RGY P +
Sbjct: 435 ALY---GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR-EVLEQVERGYRMP----CPQ 486
Query: 576 NCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
+CP ++ L+ C KK EERP F + S +E
Sbjct: 487 DCPISLHELMIHCWKKDPEERPTFEYLQSFLE 518
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 144 bits (362), Expect = 3e-34
Identities = 100/294 (34%), Positives = 156/294 (53%), Gaps = 21/294 (7%)
Query: 343 EIEASEVMLSTRIGSGSFGTVYKG------KWHGDVAVKILKVVDPTPEQFQAFRNEVAV 396
E++A+ + + +G+G FG V G K VA+K LKV T +Q + F E ++
Sbjct: 615 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKV-GYTEKQRRDFLGEASI 673
Query: 397 LRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 455
+ + H NI+ G +TK + IVT++ E SL L + +F + QL+ + R A G
Sbjct: 674 MGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASG 733
Query: 456 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV-KSRWSGSQQVEQPTGSVLWMAP 514
M YL +HRD+ + NI ++ L K+ DFGL+ V + + + W +P
Sbjct: 734 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSP 793
Query: 515 EVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKL 573
E I + F+ SDV+SYGIVL+E+M+ GE PY ++N+D +I V GY P
Sbjct: 794 EAIAYR---KFTSASDVWSYGIVLWEVMSYGERPYWEMSNQD-VIKAVDEGYRLPP---- 845
Query: 574 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL---QHSLPKINRSASEPS 624
+CP A+ +L+ DC +K + RP F QI+S ++ L SL I +A+ PS
Sbjct: 846 PMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPS 899
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 142 bits (357), Expect = 1e-33
Identities = 93/288 (32%), Positives = 154/288 (53%), Gaps = 18/288 (6%)
Query: 326 EKNKIRPRGQRD-SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP 384
EK I P+ Q+ WEI + L R+G+G FG V+ G ++ V + K + P
Sbjct: 202 EKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAV-KTLKPGT 260
Query: 385 EQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQET-KFQM 442
QAF E +++ +H ++ +T++ + I+T++ SL L E K +
Sbjct: 261 MSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLL 320
Query: 443 FQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQ 500
+LID + Q A+GM Y+ KN IHRD+++ N+ + E L KI DFGLA V + ++ +
Sbjct: 321 PKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTARE 380
Query: 501 QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIF 559
+ P + W APE I F+ +SDV+S+GI+LYE++T G++PY N D ++
Sbjct: 381 GAKFP---IKWTAPEAINF---GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD-VMT 433
Query: 560 MVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
+ +GY P + +NCP + ++ C K+ EERP F + S ++
Sbjct: 434 ALSQGYRMPRV----ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 477
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 142 bits (357), Expect = 1e-33
Identities = 93/288 (32%), Positives = 154/288 (53%), Gaps = 18/288 (6%)
Query: 326 EKNKIRPRGQRD-SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP 384
EK I P+ Q+ WEI + L R+G+G FG V+ G ++ V + K + P
Sbjct: 223 EKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAV-KTLKPGT 281
Query: 385 EQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQET-KFQM 442
QAF E +++ +H ++ +T++ + I+T++ SL L E K +
Sbjct: 282 MSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLL 341
Query: 443 FQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQ 500
+LID + Q A+GM Y+ KN IHRD+++ N+ + E L KI DFGLA V + ++ +
Sbjct: 342 PKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTARE 401
Query: 501 QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIF 559
+ P + W APE I F+ +SDV+S+GI+LYE++T G++PY N D ++
Sbjct: 402 GAKFP---IKWTAPEAINF---GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD-VMT 454
Query: 560 MVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
+ +GY P + +NCP + ++ C K+ EERP F + S ++
Sbjct: 455 ALSQGYRMPRV----ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 498
>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo
sapiens]
Length = 1005
Score = 141 bits (356), Expect = 2e-33
Identities = 100/299 (33%), Positives = 152/299 (50%), Gaps = 22/299 (7%)
Query: 334 GQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD------VAVKILKVVDPTPEQF 387
G+ S+ EIEAS + + IGSG G V G+ VA+K LK T Q
Sbjct: 620 GRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKA-GYTERQR 678
Query: 388 QAFRNEVAVLRKTRHVNILLFMGYMTKDNLA-IVTQWCEGSSLYKHLHVQETKFQMFQLI 446
+ F +E +++ + H NI+ G +T+ LA IVT++ E SL L + +F + QL+
Sbjct: 679 RDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLV 738
Query: 447 DIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPT 506
+ R GM YL +HRD+ + N+ + L K+ DFGL+ V T
Sbjct: 739 GMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLE--DDPDAAYTTT 796
Query: 507 GS---VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVG 562
G + W APE I + FS SDV+S+G+V++E++ GE PY ++ NRD +I V
Sbjct: 797 GGKIPIRWTAPEAIAFR---TFSSASDVWSFGVVMWEVLAYGERPYWNMTNRD-VISSVE 852
Query: 563 RGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSAS 621
GY P CP A+ +L+ DC K + +RP F QI+S ++ L S + +A+
Sbjct: 853 EGYRLP----APMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATAT 907
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 139 bits (350), Expect = 8e-33
Identities = 94/272 (34%), Positives = 147/272 (54%), Gaps = 20/272 (7%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WEI S + L R+G+G FG V+ G W+G VAVK LK +P+ AF E V++
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPK---AFLEEAQVMKL 312
Query: 400 TRHVNILLFMGYMTKDNLAIVTQW-CEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458
RH ++ ++++ + IVT++ C GS L + + ++ QL+D+A Q A+GM Y
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWMAPEV 516
+ N IHRD+++ NI + E L KI DFGLA + ++ Q + P + W APE
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFP---IKWTAPEA 429
Query: 517 IRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYK 575
F+ +SDV+S+GI+L EL+T G +PY +N R +++ V +GY P
Sbjct: 430 ALF---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQGYHMP----CPP 481
Query: 576 NCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
CP ++ + + EERP F + S +E
Sbjct: 482 GCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 139 bits (350), Expect = 8e-33
Identities = 94/272 (34%), Positives = 147/272 (54%), Gaps = 20/272 (7%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WEI S + L R+G+G FG V+ G W+G VAVK LK +P+ AF E V++
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPK---AFLEEAQVMKL 312
Query: 400 TRHVNILLFMGYMTKDNLAIVTQW-CEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458
RH ++ ++++ + IVT++ C GS L + + ++ QL+D+A Q A+GM Y
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWMAPEV 516
+ N IHRD+++ NI + E L KI DFGLA + ++ Q + P + W APE
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFP---IKWTAPEA 429
Query: 517 IRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYK 575
F+ +SDV+S+GI+L EL+T G +PY +N R +++ V +GY P
Sbjct: 430 ALF---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQGYHMP----CPP 481
Query: 576 NCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
CP ++ + + EERP F + S +E
Sbjct: 482 GCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 139 bits (350), Expect = 8e-33
Identities = 94/272 (34%), Positives = 147/272 (54%), Gaps = 20/272 (7%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WEI S + L R+G+G FG V+ G W+G VAVK LK +P+ AF E V++
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPK---AFLEEAQVMKL 312
Query: 400 TRHVNILLFMGYMTKDNLAIVTQW-CEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458
RH ++ ++++ + IVT++ C GS L + + ++ QL+D+A Q A+GM Y
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWMAPEV 516
+ N IHRD+++ NI + E L KI DFGLA + ++ Q + P + W APE
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFP---IKWTAPEA 429
Query: 517 IRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYK 575
F+ +SDV+S+GI+L EL+T G +PY +N R +++ V +GY P
Sbjct: 430 ALF---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQGYHMP----CPP 481
Query: 576 NCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
CP ++ + + EERP F + S +E
Sbjct: 482 GCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 139 bits (349), Expect = 1e-32
Identities = 90/274 (32%), Positives = 155/274 (56%), Gaps = 24/274 (8%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WE+ + L R+G+G FG V+ G ++G VAVK LK +P+ F A E ++++
Sbjct: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLA---EANLMKQ 294
Query: 400 TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE-TKFQMFQLIDIARQTAQGMDY 458
+H ++ +T++ + I+T++ E SL L K + +L+D+A Q A+GM +
Sbjct: 295 LQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAF 354
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWMAPEV 516
+ +N IHRD+++ NI + + L+ KI DFGLA + + ++ + + P + W APE
Sbjct: 355 IEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP---IKWTAPEA 411
Query: 517 IRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGY--ASPDLSKL 573
I + F+ +SDV+S+GI+L E++T G +PY + N ++I + RGY PD
Sbjct: 412 I---NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTN-PEVIQNLERGYRMVRPD---- 463
Query: 574 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
NCP+ + +L+ C K+ E+RP F + S +E
Sbjct: 464 --NCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 139 bits (349), Expect = 1e-32
Identities = 90/274 (32%), Positives = 155/274 (56%), Gaps = 24/274 (8%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WE+ + L R+G+G FG V+ G ++G VAVK LK +P+ F A E ++++
Sbjct: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLA---EANLMKQ 294
Query: 400 TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE-TKFQMFQLIDIARQTAQGMDY 458
+H ++ +T++ + I+T++ E SL L K + +L+D+A Q A+GM +
Sbjct: 295 LQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAF 354
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWMAPEV 516
+ +N IHRD+++ NI + + L+ KI DFGLA + + ++ + + P + W APE
Sbjct: 355 IEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP---IKWTAPEA 411
Query: 517 IRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGY--ASPDLSKL 573
I + F+ +SDV+S+GI+L E++T G +PY + N ++I + RGY PD
Sbjct: 412 I---NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTN-PEVIQNLERGYRMVRPD---- 463
Query: 574 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
NCP+ + +L+ C K+ E+RP F + S +E
Sbjct: 464 --NCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 139 bits (349), Expect = 1e-32
Identities = 94/269 (34%), Positives = 141/269 (52%), Gaps = 22/269 (8%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKT 400
WE+ E++ +GSG+ G V+ G++HG+ VAVK ++ + T ++ LRK
Sbjct: 118 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKL 168
Query: 401 RHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
+H NI+ F G T+ I+ ++C LY+ L L+D + A GM+YL
Sbjct: 169 KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL-LVDWSMGIAGGMNYL 227
Query: 460 HAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRM 519
H IIHRD+KS N+ + VKI DFG + S S G+V WMAPEVIR
Sbjct: 228 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSF---AGTVAWMAPEVIR- 283
Query: 520 QDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 579
N P S + D++S+G+VL+EL+TGE+PY +++ II+ VG + +CP
Sbjct: 284 --NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLHLPVP---SSCPD 337
Query: 580 AMKRLVADCVKKVKEERPLFPQILSSIEL 608
K L+ C RP F QIL +++
Sbjct: 338 GFKILLRQCWNSKPRNRPSFRQILLHLDI 366
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 138 bits (347), Expect = 2e-32
Identities = 92/276 (33%), Positives = 149/276 (53%), Gaps = 20/276 (7%)
Query: 343 EIEASEVMLSTRIGSGSFGTVYKG------KWHGDVAVKILKVVDPTPEQFQAFRNEVAV 396
EI+ S V + IG+G FG VYKG K VA+K LK + +Q + F +E ++
Sbjct: 613 EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKA-GYSEKQRRDFLSEASI 671
Query: 397 LRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 455
+ + H NI+ G +TK + I+T++ E +L L + +F + QL+ + R A G
Sbjct: 672 MGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAG 731
Query: 456 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS---VLWM 512
M YL N +HRD+ + NI ++ L K+ DFGL+ + G V W
Sbjct: 732 MKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWT 791
Query: 513 APEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLS 571
APE I + F+ SDV+SYGIV++E+M+ GE PY ++N+D +I + + Y P
Sbjct: 792 APEAIAYR---KFTSASDVWSYGIVMWEVMSFGERPYWDMSNQD-VINAIEQDYRLPP-- 845
Query: 572 KLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
+CP A+ +L+ DC +K + RP F +I+++++
Sbjct: 846 --PMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLD 879
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 137 bits (346), Expect = 2e-32
Identities = 91/272 (33%), Positives = 149/272 (54%), Gaps = 20/272 (7%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WEI + L ++GSG FG V+ G + + VA+K LK +PE AF E V++
Sbjct: 234 WEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPE---AFLGEANVMKA 290
Query: 400 TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE-TKFQMFQLIDIARQTAQGMDY 458
+H ++ +TK+ + IVT++ L L E ++ + +LID++ Q A+GM Y
Sbjct: 291 LQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAY 350
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA-TVKSRWSGSQQVEQPTGSVLWMAPEVI 517
+ N IHRD+++ NI + E L KI DFGLA + S ++ + + P + W APE I
Sbjct: 351 IERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFP---IKWTAPEAI 407
Query: 518 RMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYKN 576
F+ ++DV+S+G++L E++T G +PY ++N ++I + RGY P
Sbjct: 408 HF---GVFTIKADVWSFGVLLMEVVTYGRVPYPGMSN-PEVIRNLERGYRMPRPD----T 459
Query: 577 CPKAMKR-LVADCVKKVKEERPLFPQILSSIE 607
CP + R ++A+C + EERP F + S +E
Sbjct: 460 CPPELYRGVIAECWRSRPEERPTFEFLQSVLE 491
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 137 bits (346), Expect = 2e-32
Identities = 90/272 (33%), Positives = 147/272 (54%), Gaps = 20/272 (7%)
Query: 342 WEIEASEVMLSTRIGSGSFGTVYKGKW--HGDVAVKILKVVDPTPEQFQAFRNEVAVLRK 399
WEI + L ++G+G FG V+ + H VAVK +K P +AF E V++
Sbjct: 255 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMK---PGSMSVEAFLAEANVMKT 311
Query: 400 TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE-TKFQMFQLIDIARQTAQGMDY 458
+H ++ +TK+ + I+T++ SL L E +K + +LID + Q A+GM +
Sbjct: 312 LQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 371
Query: 459 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWMAPEV 516
+ +N IHRD+++ NI + L KI DFGLA V + ++ + + P + W APE
Sbjct: 372 IEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP---IKWTAPEA 428
Query: 517 IRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYK 575
I F+ +SDV+S+GI+L E++T G +PY ++N ++I + RGY P +
Sbjct: 429 INF---GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSN-PEVIRALERGYRMP----RPE 480
Query: 576 NCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
NCP+ + ++ C K EERP F I S ++
Sbjct: 481 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 136 bits (343), Expect = 5e-32
Identities = 94/276 (34%), Positives = 147/276 (53%), Gaps = 18/276 (6%)
Query: 343 EIEASEVMLSTRIGSGSFGTVYKG------KWHGDVAVKILKVVDPTPEQFQAFRNEVAV 396
EIEAS + + IG+G FG V G K VA+K LKV T +Q + F E ++
Sbjct: 647 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKV-GYTEKQRRDFLGEASI 705
Query: 397 LRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 455
+ + H NI+ G +TK + IVT++ E SL L + +F + QL+ + R + G
Sbjct: 706 MGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAG 765
Query: 456 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV-KSRWSGSQQVEQPTGSVLWMAP 514
M YL +HRD+ + NI ++ L K+ DFGL+ V + + + W AP
Sbjct: 766 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 825
Query: 515 EVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKL 573
E I + F+ SDV+SYGIV++E+++ GE PY + N+D +I V GY P
Sbjct: 826 EAIAFR---KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD-VIKAVEEGYRLPS---- 877
Query: 574 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL 609
+CP A+ +L+ DC +K + RP F +I++ ++ L
Sbjct: 878 PMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKL 913
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 136 bits (343), Expect = 5e-32
Identities = 94/276 (34%), Positives = 147/276 (53%), Gaps = 18/276 (6%)
Query: 343 EIEASEVMLSTRIGSGSFGTVYKG------KWHGDVAVKILKVVDPTPEQFQAFRNEVAV 396
EIEAS + + IG+G FG V G K VA+K LKV T +Q + F E ++
Sbjct: 669 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKV-GYTEKQRRDFLGEASI 727
Query: 397 LRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 455
+ + H NI+ G +TK + IVT++ E SL L + +F + QL+ + R + G
Sbjct: 728 MGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAG 787
Query: 456 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV-KSRWSGSQQVEQPTGSVLWMAP 514
M YL +HRD+ + NI ++ L K+ DFGL+ V + + + W AP
Sbjct: 788 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 847
Query: 515 EVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKL 573
E I + F+ SDV+SYGIV++E+++ GE PY + N+D +I V GY P
Sbjct: 848 EAIAFR---KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD-VIKAVEEGYRLPS---- 899
Query: 574 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL 609
+CP A+ +L+ DC +K + RP F +I++ ++ L
Sbjct: 900 PMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKL 935
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 136 bits (343), Expect = 5e-32
Identities = 94/300 (31%), Positives = 156/300 (52%), Gaps = 26/300 (8%)
Query: 343 EIEASEVMLSTRIGSGSFGTVYKG------KWHGDVAVKILKVVDPTPEQFQAFRNEVAV 396
EI+ S V + IG+G FG V +G K VA+K LK T Q + F +E ++
Sbjct: 609 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKG-GYTERQRREFLSEASI 667
Query: 397 LRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 455
+ + H NI+ G +T + I+T++ E +L L + + +F + QL+ + R A G
Sbjct: 668 MGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASG 727
Query: 456 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS---VLWM 512
M YL + +HRD+ + NI ++ L K+ DFGL+ S G + W
Sbjct: 728 MRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWT 787
Query: 513 APEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLS 571
APE I + F+ SD +SYGIV++E+M+ GE PY ++N+D +I + + Y P
Sbjct: 788 APEAIAFR---KFTSASDAWSYGIVMWEVMSFGERPYWDMSNQD-VINAIEQDYRLPP-- 841
Query: 572 KLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS------LPKINRSASEPSL 625
+CP ++ +L+ DC +K + RP FPQ++S+++ + + + + N AS P L
Sbjct: 842 --PPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLL 899
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 136 bits (342), Expect = 7e-32
Identities = 93/291 (31%), Positives = 155/291 (53%), Gaps = 18/291 (6%)
Query: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHGD------VAVKILKVVDPTPEQFQAFRNEVAV 396
EI+AS + + IG G FG V G+ VA+K LK T +Q + F +E ++
Sbjct: 615 EIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKA-GYTDKQRRDFLSEASI 673
Query: 397 LRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 455
+ + H NI+ G +TK + I+T++ E SL L + +F + QL+ + R G
Sbjct: 674 MGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSG 733
Query: 456 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV-KSRWSGSQQVEQPTGSVLWMAP 514
M YL + +HRD+ + NI ++ L K+ DFG++ V + + + W AP
Sbjct: 734 MKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAP 793
Query: 515 EVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKL 573
E I + F+ SDV+SYGIV++E+M+ GE PY ++N+D +I + GY P
Sbjct: 794 EAIAYR---KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQD-VIKAIEEGYRLPP---- 845
Query: 574 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS 624
+CP A+ +L+ DC +K + +RP F QI++ ++ L + + R+ +E S
Sbjct: 846 PMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESS 896
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 135 bits (340), Expect = 1e-31
Identities = 95/293 (32%), Positives = 153/293 (52%), Gaps = 20/293 (6%)
Query: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHGD------VAVKILKVVDPTPEQFQAFRNEVAV 396
EI+ S V + IG+G FG V +G+ VA+K LKV T Q + F +E ++
Sbjct: 627 EIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKV-GYTERQRRDFLSEASI 685
Query: 397 LRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 455
+ + H NI+ G +TK + I+T++ E +L L + + +F + QL+ + R A G
Sbjct: 686 MGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAG 745
Query: 456 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS---VLWM 512
M YL N +HRD+ + NI ++ L K+ DFGL+ G + W
Sbjct: 746 MKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWT 805
Query: 513 APEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLS 571
APE I + F+ SDV+SYGIV++E+M+ GE PY ++N+D +I V + Y P
Sbjct: 806 APEAIAYR---KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQD-VINAVEQDYRLPP-- 859
Query: 572 KLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS 624
+CP A+ +L+ DC + + RP F QI+++++ L + + AS S
Sbjct: 860 --PMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQS 910
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 134 bits (336), Expect = 3e-31
Identities = 91/276 (32%), Positives = 147/276 (53%), Gaps = 20/276 (7%)
Query: 343 EIEASEVMLSTRIGSGSFGTVYKG------KWHGDVAVKILKVVDPTPEQFQAFRNEVAV 396
EI+ S V + IG+G FG V G K VA+K LK T +Q + F +E ++
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKS-GYTEKQRRDFLSEASI 673
Query: 397 LRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 455
+ + H N++ G +TK + I+T++ E SL L + +F + QL+ + R A G
Sbjct: 674 MGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAG 733
Query: 456 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS---VLWM 512
M YL N +HRD+ + NI ++ L K+ DFGL+ + G + W
Sbjct: 734 MKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWT 793
Query: 513 APEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLS 571
APE I+ + F+ SDV+SYGIV++E+M+ GE PY + N+D +I + + Y P
Sbjct: 794 APEAIQYR---KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQD-VINAIEQDYRLPP-- 847
Query: 572 KLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 607
+CP A+ +L+ DC +K + RP F QI+++++
Sbjct: 848 --PMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.132 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,151,756
Number of Sequences: 37866
Number of extensions: 1173437
Number of successful extensions: 6838
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 685
Number of HSP's successfully gapped in prelim test: 242
Number of HSP's that attempted gapping in prelim test: 4434
Number of HSP's gapped (non-prelim): 1318
length of query: 648
length of database: 18,247,518
effective HSP length: 109
effective length of query: 539
effective length of database: 14,120,124
effective search space: 7610746836
effective search space used: 7610746836
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.