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Search of human proteins with 42518070
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42518070 tight junction protein 2 (zona occludens 2) isoform
1 [Homo sapiens]
(1190 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 2392 0.0
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 1925 0.0
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 762 0.0
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 749 0.0
gi|10092691 tight junction protein 3 [Homo sapiens] 565 e-161
gi|95089461 discs large homolog 5 [Homo sapiens] 140 5e-33
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 137 6e-32
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 137 6e-32
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 135 3e-31
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 133 1e-30
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 128 3e-29
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 127 8e-29
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 125 2e-28
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 125 2e-28
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 112 3e-24
gi|169160873 PREDICTED: similar to hCG2040319 [Homo sapiens] 92 4e-18
gi|239747400 PREDICTED: similar to hCG2040319 [Homo sapiens] 92 4e-18
gi|239741226 PREDICTED: similar to hCG2040319 [Homo sapiens] 92 4e-18
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 91 5e-18
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 79 2e-14
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 76 2e-13
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 75 4e-13
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 75 4e-13
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 75 4e-13
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 75 4e-13
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 74 8e-13
gi|13129124 caspase recruitment domain protein 14 isoform 1 [Hom... 73 1e-12
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 71 7e-12
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 69 3e-11
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 68 5e-11
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 2392 bits (6200), Expect = 0.0
Identities = 1190/1190 (100%), Positives = 1190/1190 (100%)
Query: 1 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG 60
MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
Sbjct: 1 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG 60
Query: 61 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR 120
ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
Sbjct: 61 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR 120
Query: 121 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP 180
KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
Sbjct: 121 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP 180
Query: 181 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS 240
HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
Sbjct: 181 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS 240
Query: 241 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR 300
RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
Sbjct: 241 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR 300
Query: 301 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN 360
GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
Sbjct: 301 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN 360
Query: 361 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR 420
MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
Sbjct: 361 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR 420
Query: 421 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ 480
HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
Sbjct: 421 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ 480
Query: 481 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE 540
EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
Sbjct: 481 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE 540
Query: 541 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA 600
GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
Sbjct: 541 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA 600
Query: 601 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP 660
CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
Sbjct: 601 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP 660
Query: 661 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE 720
NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
Sbjct: 661 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE 720
Query: 721 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR 780
RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
Sbjct: 721 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR 780
Query: 781 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF 840
QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
Sbjct: 781 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF 840
Query: 841 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR 900
DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
Sbjct: 841 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR 900
Query: 901 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE 960
MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
Sbjct: 901 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE 960
Query: 961 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS 1020
SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
Sbjct: 961 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS 1020
Query: 1021 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG 1080
AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
Sbjct: 1021 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG 1080
Query: 1081 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP 1140
KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
Sbjct: 1081 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP 1140
Query: 1141 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL 1190
EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
Sbjct: 1141 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL 1190
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 1925 bits (4987), Expect = 0.0
Identities = 970/1011 (95%), Positives = 980/1011 (96%), Gaps = 10/1011 (0%)
Query: 1 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG 60
MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
Sbjct: 1 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG 60
Query: 61 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR 120
ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
Sbjct: 61 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR 120
Query: 121 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP 180
KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
Sbjct: 121 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP 180
Query: 181 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS 240
HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
Sbjct: 181 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS 240
Query: 241 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR 300
RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
Sbjct: 241 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR 300
Query: 301 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN 360
GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
Sbjct: 301 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN 360
Query: 361 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR 420
MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
Sbjct: 361 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR 420
Query: 421 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ 480
HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
Sbjct: 421 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ 480
Query: 481 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE 540
EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
Sbjct: 481 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE 540
Query: 541 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA 600
GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
Sbjct: 541 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA 600
Query: 601 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP 660
CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
Sbjct: 601 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP 660
Query: 661 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE 720
NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
Sbjct: 661 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE 720
Query: 721 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR 780
RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
Sbjct: 721 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR 780
Query: 781 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF 840
QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
Sbjct: 781 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF 840
Query: 841 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR 900
DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
Sbjct: 841 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR 900
Query: 901 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE 960
MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
Sbjct: 901 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE 960
Query: 961 -SIRKPSPE----PRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEES 1006
I + P+ P + + Q + P PEP KA ++ +++
Sbjct: 961 IEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRP-----PEPQKAPSRPYQDT 1006
Score = 180 bits (457), Expect = 6e-45
Identities = 84/90 (93%), Positives = 86/90 (95%)
Query: 1101 QEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSD 1160
+ Q+ IEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSD
Sbjct: 954 EPVQHEEIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSD 1013
Query: 1161 AEEEEYRQQLSEHSKRGYYGQSARYRDTEL 1190
AEEEEYRQQLSEHSKRGYYGQSARYRDTEL
Sbjct: 1014 AEEEEYRQQLSEHSKRGYYGQSARYRDTEL 1043
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 762 bits (1967), Expect = 0.0
Identities = 465/1002 (46%), Positives = 607/1002 (60%), Gaps = 129/1002 (12%)
Query: 262 ERAYSPEYRRGARHDARSRG--PRSRSREHPHSRSPSPEPRG----RPG-PIGVLLMKSR 314
E + P R + RS PR RS S SP + R +P P V L+KSR
Sbjct: 134 EEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSR 193
Query: 315 ANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSR 374
NEEYGLRL S IFVKE+++ LA +DGN+ EGD++LKINGTVTENMSLTDA+ LIE+S+
Sbjct: 194 KNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSK 253
Query: 375 GKLQLVVLRDSQQTLINIPSLNDS-----DSEIEDISEIES----------------NRS 413
GKL++VV RD + TL+N+P L+DS SE +DISEI+S +RS
Sbjct: 254 GKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRS 313
Query: 414 FSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPET 473
SP++R SD+ HS + SR++ R+S+ GA TP K D V E
Sbjct: 314 RSPDQRSEP-SDHSRHSPQQPSNGSLRSRDE--ERISKPGAVSTPVKHADDHTPKTVEEV 370
Query: 474 NKEPRYQEDPPAPQPKAA------PRTFLRPSPED---------EAIYGPNTKMVRFKKG 518
E ++ P P+PK P L SP D + I P+ K+V+F+KG
Sbjct: 371 TVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKG 430
Query: 519 DSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEI 578
DSVGLRLAGGNDVGIFVAG+ E + A +EGL+EGDQIL+VN DF ++RE+AVL+LL++
Sbjct: 431 DSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDL 490
Query: 579 PKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLY 638
PKGE VTILAQ + DVYR I+ GDSF+IR+HFE EKE+P L+F +GEVFRVVDTLY
Sbjct: 491 PKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLY 550
Query: 639 DGKLGNWLAVRIG---NELEKGLIPNKSRAEQMASVQ-NAQRDNAGDRADFWRMRGQRSG 694
+GKLG+WLA+RIG E+E+G+IPNK+RAEQ+ASVQ + GDRADFWR RG RS
Sbjct: 551 NGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSS 610
Query: 695 VKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDW 754
K+NLRKSREDL+A V TKFPAYERV+LREAGF RPV +FGPIAD+A EKLA E PD
Sbjct: 611 -KRNLRKSREDLSA-QPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDI 668
Query: 755 FQTAKTEPKDAGS-EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFF 813
+Q AK+EP+DAG+ ++S+G++RL+T++QII+QDKHALLDVTP AVD LNY QW+PIV+F
Sbjct: 669 YQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFL 728
Query: 814 NPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKD 873
NPDS+QGVKTMR RL P S KS+RKL+++++KL+K HLFT TINLNS ND W+G+LK+
Sbjct: 729 NPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKE 788
Query: 874 TIQHQQGEAVWVSEGKMEGMDDDP----EDRMSYLTAMGADY--LSCDSRLISDFEDTDG 927
IQ QQ + VWVSEGK +G D +DR+SYL+A G++Y S DSR SD+EDTD
Sbjct: 789 AIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDT 848
Query: 928 EGGAYTDNELDEPAEE----PLVSSITRSSEPVQ------HEESIRKPSPEPRAQMR--- 974
EGGAYTD ELDE + P S+ITRSSEPV+ H E+ P P+AQ +
Sbjct: 849 EGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIH 908
Query: 975 -------RAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNET 1027
+ AS + +SP P PE A + + + + N + V E
Sbjct: 909 RIDSPGFKPASQQKAEASSPVPYLSPETNPASS---------TSAVNHNVNLTNVRLEEP 959
Query: 1028 PGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEK 1087
A + Y P S+ PST E +Q+ + S + K++ K
Sbjct: 960 TPAPSTSYSPQ-------ADSLRTPST-------EAAHIMLRDQEPSLSSHVDPTKVYRK 1005
Query: 1088 MDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPS 1147
+ + R + + + A HP H+PD + P P
Sbjct: 1006 DPYPEEMMRQNHVLK------QPAVSHPG--------HRPD---------KEPNLTYEPQ 1042
Query: 1148 RPYQDTRGSYGSDAEEEEYRQQLSEHSKR--GYYGQSARYRD 1187
PY + + S D E+ YR + S ++ + Y RY D
Sbjct: 1043 LPYVEKQAS--RDLEQPTYRYESSSYTDQFSRNYEHRLRYED 1082
Score = 157 bits (398), Expect = 4e-38
Identities = 95/184 (51%), Positives = 117/184 (63%), Gaps = 18/184 (9%)
Query: 20 RAPGMEEL-IWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGL 78
++ MEE IWEQ+TVTL + GFGIA+SGGRDNPHF++GETSIVISDVL GGPA+G
Sbjct: 9 KSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQ 68
Query: 79 LQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDR 138
LQENDRV MVNG M++V H+FAVQQLRKSGK A I ++R +KVQ+ + P D+
Sbjct: 69 LQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNE 128
Query: 139 AFEVMDEF-DGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSR 197
+E D RS RSG R E+ P +R+ SRER LS RS
Sbjct: 129 EDSYDEEIHDPRSGRSGVVNR---------------RSEKIWPRDRSASRERSLS-PRSD 172
Query: 198 GRSL 201
RS+
Sbjct: 173 RRSV 176
Score = 63.2 bits (152), Expect = 1e-09
Identities = 73/285 (25%), Positives = 118/285 (41%), Gaps = 40/285 (14%)
Query: 928 EGGAYTDNELDEPAEEPLVSSITRSSEPVQHEES---------IRKPSP---EPRAQMRR 975
E +Y D++ P+ P + ++ + QH E +P+P + R + +
Sbjct: 1089 EQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQ 1148
Query: 976 AASSDQLRDNSPP-----------PAFKPEPPKAKTQNKEESY--DFSKSYEY--KSNPS 1020
A + LR P P +P P + + Y +S+SYE +
Sbjct: 1149 APRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFT 1208
Query: 1021 AVAGNETPGASTKGYPPPVAA---KPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKS 1077
+ AG+ P PP + + KP S KP P P Q EE E+ P+S
Sbjct: 1209 SRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEE-----EDPAMKPQS 1263
Query: 1078 VLGKVKIFEKMDHKARLQRMQELQEAQNARI-EIAQKHPDIYAV-PIKTHKPDPGTPQHT 1135
VL +VK+FE A L+ +++ + + + E+A K + P T + T
Sbjct: 1264 VLTRVKMFENK-RSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKT 1322
Query: 1136 SSRPPEPQKAPSRPYQDTRGS--YGSDAEEEEYRQQLSEHSKRGY 1178
R PEPQK +P +D S Y + +EE YR+QLS +R +
Sbjct: 1323 LYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSF 1367
Score = 45.8 bits (107), Expect = 2e-04
Identities = 64/271 (23%), Positives = 104/271 (38%), Gaps = 70/271 (25%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
+ I + ++ + G A +G L E D + +NG +N+ A + + KS GK + +R
Sbjct: 52 TSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKS-GKNAKITIRR 108
Query: 385 SQQTLINIP-------SLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKE 437
++ I + S N+ DS E+I + S RS R + D +S E+
Sbjct: 109 KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRER--- 165
Query: 438 RPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLR 497
S R D S S A PT
Sbjct: 166 SLSPRSDRRSVASSQPAKPT---------------------------------------- 185
Query: 498 PSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEG-LQEGDQIL 556
+V+ +K + GLRLA IFV I + + A ++G +QEGD +L
Sbjct: 186 -----------KVTLVKSRKNEEYGLRLAS----HIFVKEISQDSLAARDGNIQEGDVVL 230
Query: 557 KVNTQDFRGLVREDAVLYLLEIPKGEMVTIL 587
K+N + DA L+E KG++ ++
Sbjct: 231 KINGTVTENMSLTDAKT-LIERSKGKLKMVV 260
Score = 44.7 bits (104), Expect = 5e-04
Identities = 74/304 (24%), Positives = 112/304 (36%), Gaps = 53/304 (17%)
Query: 76 DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQ 135
DG +QE D V+ +NGT E++ + A + +S +VV+R + A L P L
Sbjct: 220 DGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER---ATLLNVPDLSD 276
Query: 136 DDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERD-LSRD 194
+ + D +S S+ H GRS RP R+RSR D S
Sbjct: 277 SIHSANASERDDISEIQSLASD------HSGRSHD--------RPPRRSRSRSPDQRSEP 322
Query: 195 RSRGRSLERGLDQDHARTRDRSR-------GRSLERGLDHDFGPSRDRDRDRSRGRSID- 246
R + R+RD R ++ DH + +R+ ++
Sbjct: 323 SDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSL 382
Query: 247 QDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPI 306
+ + Y + PD + SP S G S PS
Sbjct: 383 PEPKPVYAQVGQPDVDLPVSP-----------SDGVLPNSTHEDGILRPS---------- 421
Query: 307 GVLLMKSRANEEYGLRLGS----QIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMS 362
+ L+K R + GLRL IFV + A K+G L EGD IL++N N+
Sbjct: 422 -MKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 363 LTDA 366
+A
Sbjct: 480 REEA 483
Score = 33.1 bits (74), Expect = 1.6
Identities = 25/102 (24%), Positives = 45/102 (44%), Gaps = 9/102 (8%)
Query: 501 EDEAIYGPNTKMVRFKKGDSVGLRLAGGND--------VGIFVAGIQEGTSAEQEGLQEG 552
E+ AI+ +T + G G+ ++GG D I ++ + +G AE + LQE
Sbjct: 14 EETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQ-LQEN 72
Query: 553 DQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADV 594
D++ VN + AV L + K +TI + + +
Sbjct: 73 DRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQI 114
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 749 bits (1935), Expect = 0.0
Identities = 426/796 (53%), Positives = 538/796 (67%), Gaps = 76/796 (9%)
Query: 262 ERAYSPEYRRGARHDARSRG--PRSRSREHPHSRSPSPEPRG----RPG-PIGVLLMKSR 314
E + P R + RS PR RS S SP + R +P P V L+KSR
Sbjct: 134 EEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSR 193
Query: 315 ANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSR 374
NEEYGLRL S IFVKE+++ LA +DGN+ EGD++LKINGTVTENMSLTDA+ LIE+S+
Sbjct: 194 KNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSK 253
Query: 375 GKLQLVVLRDSQQTLINIPSLNDS-----DSEIEDISEIES----------------NRS 413
GKL++VV RD + TL+N+P L+DS SE +DISEI+S +RS
Sbjct: 254 GKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRS 313
Query: 414 FSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPET 473
SP++R SD+ HS + SR++ R+S+ GA TP K D V E
Sbjct: 314 RSPDQRSEP-SDHSRHSPQQPSNGSLRSRDE--ERISKPGAVSTPVKHADDHTPKTVEEV 370
Query: 474 NKEPRYQEDPPAPQPKAA------PRTFLRPSPED---------EAIYGPNTKMVRFKKG 518
E ++ P P+PK P L SP D + I P+ K+V+F+KG
Sbjct: 371 TVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKG 430
Query: 519 DSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEI 578
DSVGLRLAGGNDVGIFVAG+ E + A +EGL+EGDQIL+VN DF ++RE+AVL+LL++
Sbjct: 431 DSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDL 490
Query: 579 PKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLY 638
PKGE VTILAQ + DVYR I+ GDSF+IR+HFE EKE+P L+F +GEVFRVVDTLY
Sbjct: 491 PKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLY 550
Query: 639 DGKLGNWLAVRIG---NELEKGLIPNKSRAEQMASVQ-NAQRDNAGDRADFWRMRGQRSG 694
+GKLG+WLA+RIG E+E+G+IPNK+RAEQ+ASVQ + GDRADFWR RG RS
Sbjct: 551 NGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSS 610
Query: 695 VKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDW 754
K+NLRKSREDL+A V TKFPAYERV+LREAGF RPV +FGPIAD+A EKLA E PD
Sbjct: 611 -KRNLRKSREDLSA-QPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDI 668
Query: 755 FQTAKTEPKDAGS-EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFF 813
+Q AK+EP+DAG+ ++S+G++RL+T++QII+QDKHALLDVTP AVD LNY QW+PIV+F
Sbjct: 669 YQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFL 728
Query: 814 NPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKD 873
NPDS+QGVKTMR RL P S KS+RKL+++++KL+K HLFT TINLNS ND W+G+LK+
Sbjct: 729 NPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKE 788
Query: 874 TIQHQQGEAVWVSEGKMEGMDDDP----EDRMSYLTAMGADY--LSCDSRLISDFEDTDG 927
IQ QQ + VWVSEGK +G D +DR+SYL+A G++Y S DSR SD+EDTD
Sbjct: 789 AIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDT 848
Query: 928 EGGAYTDNELDEPAEE----PLVSSITRSSEPVQ------HEESIRKPSPEPRAQMRRAA 977
EGGAYTD ELDE + P S+ITRSSEPV+ H E+ P P+AQ +
Sbjct: 849 EGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIH 908
Query: 978 SSDQLRDNSPPPAFKP 993
D P FKP
Sbjct: 909 RIDS-------PGFKP 917
Score = 157 bits (398), Expect = 4e-38
Identities = 95/184 (51%), Positives = 117/184 (63%), Gaps = 18/184 (9%)
Query: 20 RAPGMEEL-IWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGL 78
++ MEE IWEQ+TVTL + GFGIA+SGGRDNPHF++GETSIVISDVL GGPA+G
Sbjct: 9 KSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQ 68
Query: 79 LQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDR 138
LQENDRV MVNG M++V H+FAVQQLRKSGK A I ++R +KVQ+ + P D+
Sbjct: 69 LQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNE 128
Query: 139 AFEVMDEF-DGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSR 197
+E D RS RSG R E+ P +R+ SRER LS RS
Sbjct: 129 EDSYDEEIHDPRSGRSGVVNR---------------RSEKIWPRDRSASRERSLS-PRSD 172
Query: 198 GRSL 201
RS+
Sbjct: 173 RRSV 176
Score = 63.2 bits (152), Expect = 1e-09
Identities = 73/285 (25%), Positives = 118/285 (41%), Gaps = 40/285 (14%)
Query: 928 EGGAYTDNELDEPAEEPLVSSITRSSEPVQHEES---------IRKPSP---EPRAQMRR 975
E +Y D++ P+ P + ++ + QH E +P+P + R + +
Sbjct: 1009 EQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQ 1068
Query: 976 AASSDQLRDNSPP-----------PAFKPEPPKAKTQNKEESY--DFSKSYEY--KSNPS 1020
A + LR P P +P P + + Y +S+SYE +
Sbjct: 1069 APRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFT 1128
Query: 1021 AVAGNETPGASTKGYPPPVAA---KPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKS 1077
+ AG+ P PP + + KP S KP P P Q EE E+ P+S
Sbjct: 1129 SRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEE-----EDPAMKPQS 1183
Query: 1078 VLGKVKIFEKMDHKARLQRMQELQEAQNARI-EIAQKHPDIYAV-PIKTHKPDPGTPQHT 1135
VL +VK+FE A L+ +++ + + + E+A K + P T + T
Sbjct: 1184 VLTRVKMFENK-RSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKT 1242
Query: 1136 SSRPPEPQKAPSRPYQDTRGS--YGSDAEEEEYRQQLSEHSKRGY 1178
R PEPQK +P +D S Y + +EE YR+QLS +R +
Sbjct: 1243 LYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSF 1287
Score = 45.8 bits (107), Expect = 2e-04
Identities = 64/271 (23%), Positives = 104/271 (38%), Gaps = 70/271 (25%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
+ I + ++ + G A +G L E D + +NG +N+ A + + KS GK + +R
Sbjct: 52 TSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKS-GKNAKITIRR 108
Query: 385 SQQTLINIP-------SLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKE 437
++ I + S N+ DS E+I + S RS R + D +S E+
Sbjct: 109 KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRER--- 165
Query: 438 RPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLR 497
S R D S S A PT
Sbjct: 166 SLSPRSDRRSVASSQPAKPT---------------------------------------- 185
Query: 498 PSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEG-LQEGDQIL 556
+V+ +K + GLRLA IFV I + + A ++G +QEGD +L
Sbjct: 186 -----------KVTLVKSRKNEEYGLRLAS----HIFVKEISQDSLAARDGNIQEGDVVL 230
Query: 557 KVNTQDFRGLVREDAVLYLLEIPKGEMVTIL 587
K+N + DA L+E KG++ ++
Sbjct: 231 KINGTVTENMSLTDAKT-LIERSKGKLKMVV 260
Score = 44.7 bits (104), Expect = 5e-04
Identities = 74/304 (24%), Positives = 112/304 (36%), Gaps = 53/304 (17%)
Query: 76 DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQ 135
DG +QE D V+ +NGT E++ + A + +S +VV+R + A L P L
Sbjct: 220 DGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER---ATLLNVPDLSD 276
Query: 136 DDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERD-LSRD 194
+ + D +S S+ H GRS RP R+RSR D S
Sbjct: 277 SIHSANASERDDISEIQSLASD------HSGRSHD--------RPPRRSRSRSPDQRSEP 322
Query: 195 RSRGRSLERGLDQDHARTRDRSR-------GRSLERGLDHDFGPSRDRDRDRSRGRSID- 246
R + R+RD R ++ DH + +R+ ++
Sbjct: 323 SDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSL 382
Query: 247 QDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPI 306
+ + Y + PD + SP S G S PS
Sbjct: 383 PEPKPVYAQVGQPDVDLPVSP-----------SDGVLPNSTHEDGILRPS---------- 421
Query: 307 GVLLMKSRANEEYGLRLGS----QIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMS 362
+ L+K R + GLRL IFV + A K+G L EGD IL++N N+
Sbjct: 422 -MKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 363 LTDA 366
+A
Sbjct: 480 REEA 483
Score = 33.1 bits (74), Expect = 1.6
Identities = 25/102 (24%), Positives = 45/102 (44%), Gaps = 9/102 (8%)
Query: 501 EDEAIYGPNTKMVRFKKGDSVGLRLAGGND--------VGIFVAGIQEGTSAEQEGLQEG 552
E+ AI+ +T + G G+ ++GG D I ++ + +G AE + LQE
Sbjct: 14 EETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQ-LQEN 72
Query: 553 DQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADV 594
D++ VN + AV L + K +TI + + +
Sbjct: 73 DRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQI 114
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 565 bits (1456), Expect = e-161
Identities = 341/793 (43%), Positives = 481/793 (60%), Gaps = 57/793 (7%)
Query: 226 DHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSR 285
D D GP R + D+ RG D D R++D R R H RS G S
Sbjct: 132 DEDDGPQRVEEVDQGRG--YDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSE 189
Query: 286 SR----EHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKD 341
+ R P + + + P+ +L+K R +EE+G++LGSQIF+K +T +GLA +
Sbjct: 190 ANGLALVSGFKRLPRQDVQMK--PVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARH 247
Query: 342 GNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINI-PSLNDSDS 400
L EGD+IL+ING ++N+SL D R+LIEKS GKL L+VLRD Q L+NI P+++DSDS
Sbjct: 248 RGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDS 307
Query: 401 EIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSR----MGATP 456
+ ++ SP D + +L + P S P R ++ T
Sbjct: 308 SPLEEGVTMADEMSSPPA--------DISDLASELSQAPPSHIPPPPRHAQRSPEASQTD 359
Query: 457 TPFKSTG-DIAGTVVPETNKEPRYQ-EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVR 514
+P +S +V T EP Q + P R S ED Y P+T++VR
Sbjct: 360 SPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRG-YSPDTRVVR 418
Query: 515 FKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLY 574
F KG S+GLRLAGGNDVGIFV+G+Q G+ A+ +G+QEGDQIL+VN F+ L RE+AV +
Sbjct: 419 FLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQF 478
Query: 575 LLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVV 634
LL +P GE + ++ Q + D++ ++ GDSF+IR+HFE E P L FTRG+VF V+
Sbjct: 479 LLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVL 538
Query: 635 DTLYDG------KLGNWLAVRIGNEL---EKGLIPNKSRAEQMASVQNAQR-------DN 678
DTL+ G + G+WLAVR+G +L E+G+IPN+SRAEQ+AS++ AQR +
Sbjct: 539 DTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSS 598
Query: 679 AGD--RADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLF 736
AG RA+FWR+RG R G KK ++SREDL+A+ ++P YERV+LREA FKRPVV+
Sbjct: 599 AGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTR-QGRYPPYERVVLREASFKRPVVIL 657
Query: 737 GPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPK 796
GP+ADIAM+KL E+PD F+ A+T + ++ + +++L+TVR I E+DKHALLDVTP
Sbjct: 658 GPVADIAMQKLTAEMPDQFEIAETVSR---TDSPSKIIKLDTVRVIAEKDKHALLDVTPS 714
Query: 797 AVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTA 856
A++ LNY Q++PIV+FF P+SR +K +RQ L P S +S+R+L+ QA KL+K +HLFTA
Sbjct: 715 AIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTA 774
Query: 857 TINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDS 916
TI LN +D+W+ LK I+ QQ +W +E +++G +D D + A + LSCDS
Sbjct: 775 TIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDS 834
Query: 917 RLISDFEDTDGEGGAYTDNE---------LDEPAEEPLVSSITRSSEPVQHEESIRKPSP 967
R+ SD+E TDGEGGAYTD E + +EP ++ RSSEPVQ +ES + P
Sbjct: 835 RVNSDYE-TDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADES-QSPRD 892
Query: 968 EPRAQMRRAASSD 980
R + A D
Sbjct: 893 RGRISAHQGAQVD 905
Score = 136 bits (342), Expect = 1e-31
Identities = 78/170 (45%), Positives = 102/170 (60%), Gaps = 20/170 (11%)
Query: 24 MEEL-IWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQEN 82
MEEL IWEQ+T TL KD +RGFGIA+SGGRD P S+V+SDV+PGGPA+G LQ
Sbjct: 20 MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPG-----GSMVVSDVVPGGPAEGRLQTG 74
Query: 83 DRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASP------PLDQD 136
D +VMVNG ME+ +FA+Q L+ K+A I VKRPR++ + A +ASP D+D
Sbjct: 75 DHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDED 134
Query: 137 DRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARS 186
D V + GR + +S G RSW++ R RP R R+
Sbjct: 135 DGPQRVEEVDQGRGYDG--------DSSSGSGRSWDERSRRPRPGRRGRA 176
Score = 45.8 bits (107), Expect = 2e-04
Identities = 62/273 (22%), Positives = 107/273 (39%), Gaps = 35/273 (12%)
Query: 322 RLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVV 381
R G + V ++ G A +G L GD I+ +NG EN + A ++++ + V
Sbjct: 51 RPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITV 108
Query: 382 LRDSQQTLINIPSLNDSDSE--IEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERP 439
R + I++P+ S S +D E + + ++ Y S ER
Sbjct: 109 KRPRR---IHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDER- 164
Query: 440 SSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPS 499
SR P R R G+ G A + A F R
Sbjct: 165 -SRRPRPGRRGRAGSHGRRSPGGGSEANGL--------------------ALVSGFKRLP 203
Query: 500 PEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE-GTSAEQEGLQEGDQILKV 558
+D + + +V+ + + G++L IF+ I + G +A GLQEGD IL++
Sbjct: 204 RQDVQMKPVKSVLVKRRDSEEFGVKLGS----QIFIKHITDSGLAARHRGLQEGDLILQI 259
Query: 559 NTQDFRGLVREDAVLYLLEIPKGEMVTILAQSR 591
N + L D L+E +G++ ++ + R
Sbjct: 260 NGVSSQNLSLND-TRRLIEKSEGKLSLLVLRDR 291
Score = 38.5 bits (88), Expect = 0.038
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 9/65 (13%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGL-LQENDRVVMVNGTPMEDVLHSF 100
+ G+ ++GG D I +S V G PADG +QE D+++ VN P +++
Sbjct: 423 KSIGLRLAGGND--------VGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREE 474
Query: 101 AVQQL 105
AVQ L
Sbjct: 475 AVQFL 479
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 140 bits (354), Expect = 5e-33
Identities = 122/477 (25%), Positives = 221/477 (46%), Gaps = 55/477 (11%)
Query: 456 PTPFKSTGDIAGTVVPETNK--EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMV 513
P ST +GT PE +P ++D P A + ++ P +
Sbjct: 1446 PAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFI 1505
Query: 514 RFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAE-QEGLQEGDQILKVNTQDFRGLVREDAV 572
+ K +G+ L GGN G+FVA +++ + A+ +GL GD IL+ + D R E+
Sbjct: 1506 K-KSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVY 1564
Query: 573 LYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFR 632
+ +L+ G V + Q R + + GDSF+IR+ ++ + Q L+F + ++
Sbjct: 1565 VEMLKPRDG--VRLKVQYRPEEFTKAKGLP-GDSFYIRALYDRLADVEQELSFKKDDILY 1621
Query: 633 VVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQ----MASVQNAQRDN------- 678
V DTL G G+W+A ++ ++++G IP+K +Q S+ + DN
Sbjct: 1622 VDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLS 1681
Query: 679 AGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVST-KFP--------AYERVLLREAGF 729
A R F+R + + K++ K +DL A+ + S+ P AY+RV +
Sbjct: 1682 AAARRSFFRRKHKH---KRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTA 1738
Query: 730 KRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSE---------------KSTG-- 772
RPV++ GP+ D+ E L NE P F E A + + +G
Sbjct: 1739 LRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHF 1798
Query: 773 -VVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRL--- 828
V + ++++I E+++H LLD+ P A++ L++ +PIVIF + S + +K R +
Sbjct: 1799 DVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLR 1858
Query: 829 NPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
+ + + S++ F+ A KL++ + FT I A S + + +Q + +W+
Sbjct: 1859 DKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQ-GGALSSICTQILAMVNQEQNKVLWI 1914
Score = 46.2 bits (108), Expect = 2e-04
Identities = 28/92 (30%), Positives = 51/92 (55%), Gaps = 3/92 (3%)
Query: 506 YGPNTKMVRFKKG-DSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFR 564
Y + V+ +KG + +G+ + G GI+V+ + G+ A Q GL+ GDQ+L+ N + R
Sbjct: 1344 YVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLR 1403
Query: 565 GLVREDAVLYLLEIPKGEMVTILAQSRADVYR 596
+ A L + + + + +TILAQ V++
Sbjct: 1404 SATEQQARLIIGQ--QCDTITILAQYNPHVHQ 1433
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 317 EEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGK 376
++ G+ L + ++ + A K+G+L GD I+ ING +N SL + L+ +
Sbjct: 728 KDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDS 787
Query: 377 LQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSS 432
L L +L+ Q+ + S + I+D ++ S R+ PE + H + H++S
Sbjct: 788 LTLSLLKVFPQS--SSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNS 841
Score = 31.2 bits (69), Expect = 6.1
Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 6/53 (11%)
Query: 46 IAVSGGRDNP-HFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMED 95
I +SG +D+ ENG + + VLPG PA +G L DR+V +NG +++
Sbjct: 722 INLSGQKDSGISLENG---VYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDN 771
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 137 bits (345), Expect = 6e-32
Identities = 166/677 (24%), Positives = 275/677 (40%), Gaps = 148/677 (21%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
+ I+V ++ G A KDG L GD +L +N E ++ +A +++ + ++V L+
Sbjct: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 381
Query: 385 SQQTLINI------PSLNDSDSEIEDISEIESNRS---------------FSPEERRHQY 423
+ T I + P + S S + + N +SP + H
Sbjct: 382 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK-HML 440
Query: 424 SDYDY-------HSSSEKLKERPSS-REDTPSRLSRMGATPTPFKSTGDIAGTVVPETNK 475
D DY +S+ KL ++P+S R +P + P+ ++P++
Sbjct: 441 VDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSH---YHLGLLPDSEM 497
Query: 476 EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIF 534
Q QP + + ++ G K+V K +G + GG D GIF
Sbjct: 498 TSHSQHSTATRQPSMTLQRAV-------SLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF 550
Query: 535 VAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRAD 593
V+ I G A+ G LQ GDQIL VN D RG E A L G+ VTI+AQ + +
Sbjct: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPE 608
Query: 594 VYRDI---------------LACGRGD-------SFFIRSHFECEKETP-----QSLAFT 626
Y ++ G G S ++R+ F+ +K Q L+F
Sbjct: 609 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFK 668
Query: 627 RGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQR- 676
G++ V++ D W A R+ G+ E G+IP+K R E+ + NA+
Sbjct: 669 YGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPG 725
Query: 677 --DNAGDRAD-------------FWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYER 721
D+ G D F++ + Q + + +EDL +YE
Sbjct: 726 VIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---------SYEP 776
Query: 722 VLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---------------- 762
V +E + RPV++ GP+ D + L +E PD F + T P
Sbjct: 777 VTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVIS 836
Query: 763 -----KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFP 808
KD K + N +VR + E+ KH +LDV+ A+ L Q +P
Sbjct: 837 REQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYP 896
Query: 809 IVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWF 868
I IF P S + + M +RL + + ++K +D+A KL++ FTA + ++ D +
Sbjct: 897 IAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDI-Y 952
Query: 869 GSLKDTIQHQQGEAVWV 885
K I+ Q G +W+
Sbjct: 953 NQCKLVIEEQSGPFIWI 969
Score = 66.6 bits (161), Expect = 1e-10
Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 26 ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83
E+ +E +TL++ + G G +++GG DNPH + I I+ ++PGG A DG L+ ND
Sbjct: 196 EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 253
Query: 84 RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
++ VN + +V HS AV+ L+++G + + V+R R +
Sbjct: 254 CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 292
Score = 57.4 bits (137), Expect = 8e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
+G G +++GG N H G+ SI ++ ++ GG A DG LQ DR++MVN +E+V H
Sbjct: 306 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 364
Query: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
AV L+ + +V + V +P + + P +
Sbjct: 365 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 398
Score = 45.4 bits (106), Expect = 3e-04
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)
Query: 30 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87
E V L K S G G + GG D GE I +S +L GGPAD G LQ D+++
Sbjct: 523 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 574
Query: 88 VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
VNG + H A L+ +G+ I+ +
Sbjct: 575 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 604
Score = 33.9 bits (76), Expect = 0.95
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
+ ++G+S +G +AGG +D GIF+ I G +A ++G L+ D IL+VN D
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
+ AV L E G +V + + R + ++
Sbjct: 264 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 297
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 137 bits (345), Expect = 6e-32
Identities = 166/677 (24%), Positives = 275/677 (40%), Gaps = 148/677 (21%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
+ I+V ++ G A KDG L GD +L +N E ++ +A +++ + ++V L+
Sbjct: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 276
Query: 385 SQQTLINI------PSLNDSDSEIEDISEIESNRS---------------FSPEERRHQY 423
+ T I + P + S S + + N +SP + H
Sbjct: 277 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK-HML 335
Query: 424 SDYDY-------HSSSEKLKERPSS-REDTPSRLSRMGATPTPFKSTGDIAGTVVPETNK 475
D DY +S+ KL ++P+S R +P + P+ ++P++
Sbjct: 336 VDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSH---YHLGLLPDSEM 392
Query: 476 EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIF 534
Q QP + + ++ G K+V K +G + GG D GIF
Sbjct: 393 TSHSQHSTATRQPSMTLQRAV-------SLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF 445
Query: 535 VAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRAD 593
V+ I G A+ G LQ GDQIL VN D RG E A L G+ VTI+AQ + +
Sbjct: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPE 503
Query: 594 VYRDI---------------LACGRGD-------SFFIRSHFECEKETP-----QSLAFT 626
Y ++ G G S ++R+ F+ +K Q L+F
Sbjct: 504 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFK 563
Query: 627 RGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQR- 676
G++ V++ D W A R+ G+ E G+IP+K R E+ + NA+
Sbjct: 564 YGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPG 620
Query: 677 --DNAGDRAD-------------FWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYER 721
D+ G D F++ + Q + + +EDL +YE
Sbjct: 621 VIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---------SYEP 671
Query: 722 VLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---------------- 762
V +E + RPV++ GP+ D + L +E PD F + T P
Sbjct: 672 VTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVIS 731
Query: 763 -----KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFP 808
KD K + N +VR + E+ KH +LDV+ A+ L Q +P
Sbjct: 732 REQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYP 791
Query: 809 IVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWF 868
I IF P S + + M +RL + + ++K +D+A KL++ FTA + ++ D +
Sbjct: 792 IAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDI-Y 847
Query: 869 GSLKDTIQHQQGEAVWV 885
K I+ Q G +W+
Sbjct: 848 NQCKLVIEEQSGPFIWI 864
Score = 66.6 bits (161), Expect = 1e-10
Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 26 ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83
E+ +E +TL++ + G G +++GG DNPH + I I+ ++PGG A DG L+ ND
Sbjct: 91 EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 148
Query: 84 RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
++ VN + +V HS AV+ L+++G + + V+R R +
Sbjct: 149 CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 187
Score = 57.4 bits (137), Expect = 8e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
+G G +++GG N H G+ SI ++ ++ GG A DG LQ DR++MVN +E+V H
Sbjct: 201 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 259
Query: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
AV L+ + +V + V +P + + P +
Sbjct: 260 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 293
Score = 45.4 bits (106), Expect = 3e-04
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)
Query: 30 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87
E V L K S G G + GG D GE I +S +L GGPAD G LQ D+++
Sbjct: 418 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 469
Query: 88 VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
VNG + H A L+ +G+ I+ +
Sbjct: 470 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 499
Score = 33.9 bits (76), Expect = 0.95
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
+ ++G+S +G +AGG +D GIF+ I G +A ++G L+ D IL+VN D
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
+ AV L E G +V + + R + ++
Sbjct: 159 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 192
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 135 bits (339), Expect = 3e-31
Identities = 156/632 (24%), Positives = 257/632 (40%), Gaps = 128/632 (20%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
+ I+V ++ G A KDG L GD +L +N E ++ +A +++ + ++V L+
Sbjct: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 225
Query: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
+ T I + + + S+SP H S ++ L+ + S
Sbjct: 226 GKPTTIYMT---------DPYGPPDITHSYSPPMENHLLS-----GNNGTLEYKTSLPPI 271
Query: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEA 504
+P R S I ++ + + Q QP + + +
Sbjct: 272 SPGRYS-------------PIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAV-------S 311
Query: 505 IYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQD 562
+ G K+V K +G + GG D GIFV+ I G A+ G LQ GDQIL VN D
Sbjct: 312 LEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 563 FRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDI---------------LACGRGD-- 605
RG E A L G+ VTI+AQ + + Y ++ G G
Sbjct: 372 LRGASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR 429
Query: 606 -----SFFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRI---GN 652
S ++R+ F+ +K Q L+F G++ V++ D W A R+ G+
Sbjct: 430 TNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGD 486
Query: 653 ELEKGLIPNKSRAEQMASVQ------NAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDL 706
E G+IP+K R E+ + NA+ + D + G K + +EDL
Sbjct: 487 SEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKT--LRGQEDL 544
Query: 707 TAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP- 762
+YE V +E + RPV++ GP+ D + L +E PD F + T P
Sbjct: 545 IL---------SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK 595
Query: 763 --------------------KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDV 793
KD K + N +VR + E+ KH +LDV
Sbjct: 596 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 655
Query: 794 TPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHL 853
+ A+ L Q +PI IF P S + + M +RL + + ++K +D+A KL++
Sbjct: 656 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEY 712
Query: 854 FTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
FTA + ++ D + K I+ Q G +W+
Sbjct: 713 FTAIVQGDTLEDI-YNQCKLVIEEQSGPFIWI 743
Score = 66.6 bits (161), Expect = 1e-10
Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 26 ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83
E+ +E +TL++ + G G +++GG DNPH + I I+ ++PGG A DG L+ ND
Sbjct: 40 EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 97
Query: 84 RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
++ VN + +V HS AV+ L+++G + + V+R R +
Sbjct: 98 CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 136
Score = 57.4 bits (137), Expect = 8e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
+G G +++GG N H G+ SI ++ ++ GG A DG LQ DR++MVN +E+V H
Sbjct: 150 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 208
Query: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
AV L+ + +V + V +P + + P +
Sbjct: 209 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 242
Score = 45.4 bits (106), Expect = 3e-04
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)
Query: 30 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87
E V L K S G G + GG D GE I +S +L GGPAD G LQ D+++
Sbjct: 315 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 366
Query: 88 VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
VNG + H A L+ +G+ I+ +
Sbjct: 367 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
Score = 37.4 bits (85), Expect = 0.086
Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 8/69 (11%)
Query: 515 FKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGL 566
FK +G +AGG D I+V I +G +A+++G LQ GD++L VN +
Sbjct: 146 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 205
Query: 567 VREDAVLYL 575
E+AV L
Sbjct: 206 THEEAVAIL 214
Score = 33.9 bits (76), Expect = 0.95
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
+ ++G+S +G +AGG +D GIF+ I G +A ++G L+ D IL+VN D
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
+ AV L E G +V + + R + ++
Sbjct: 108 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 141
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 133 bits (334), Expect = 1e-30
Identities = 155/664 (23%), Positives = 276/664 (41%), Gaps = 119/664 (17%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
S IF+ ++ G A +DG L D IL++N +++ + A + ++++ ++L V R
Sbjct: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
Query: 385 S--QQTLINIPSLND------------------SDSEIEDISEIESNRSFSPEERRHQYS 424
+ ++ I + D+ I IE + ++ + Q
Sbjct: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH--KDGKLQIG 368
Query: 425 DYDYHSSSEKLKE-----RPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRY 479
D ++ L+E ++ ++T + A PT A + ++ +P
Sbjct: 369 DKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
Query: 480 QEDPPAPQPKAAPRTFLRPSPEDEAIYGPNT------KMVRFKKGDSVGLRLAGGND-VG 532
P+ P + R SP +A+ G + K+V + +G + GG D G
Sbjct: 429 NHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG 488
Query: 533 IFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSR 591
IF++ I G A+ G L++GD+I+ VN+ D R E A L G+ VTI+AQ R
Sbjct: 489 IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYR 546
Query: 592 ADVY---------------RDILACGRGD-------SFFIRSHFECEKETP-----QSLA 624
+ Y ++ G G S ++R+ F+ +K Q L
Sbjct: 547 PEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLN 606
Query: 625 FTRGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQ 675
F G++ V++ D W A ++ G E G+IP+K R E+ + N++
Sbjct: 607 FKFGDILHVINASDDEW---WQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSK 663
Query: 676 RDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFP-AYERVLLREAGFKRPVV 734
+ G+ D +G K++ + D + ++ +YE V +E + RPV+
Sbjct: 664 TRDKGEIPDDMGSKGL-----KHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVI 718
Query: 735 LFGPIADIAMEKLANELPDWFQTA---KTEP---------------------KDAGSEKS 770
+ GP+ D + L +E PD F + T P KD K
Sbjct: 719 ILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKF 778
Query: 771 TGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGV 821
+ N +VR++ E+ KH +LDV+ A+ L Q +PI IF P S + +
Sbjct: 779 IEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI 838
Query: 822 KTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGE 881
M +RL + + +RK F++A KL++ FTA + ++ D + +K I+ Q G
Sbjct: 839 MEMNKRL---TEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDI-YNQVKQIIEEQSGS 894
Query: 882 AVWV 885
+WV
Sbjct: 895 YIWV 898
Score = 67.4 bits (163), Expect = 8e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 4/96 (4%)
Query: 29 WEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVV 86
+E +TL++ + G G +++GG DNPH + ++SI I+ ++ GG A DG L+ ND ++
Sbjct: 220 YEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DSSIFITKIITGGAAAQDGRLRVNDCIL 277
Query: 87 MVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
VN + DV HS AV+ L+++G + + VKR + V
Sbjct: 278 RVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Score = 52.0 bits (123), Expect = 3e-06
Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 3/94 (3%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +E+V H
Sbjct: 327 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHE 385
Query: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
AV L+ + + V +P + + A P +
Sbjct: 386 EAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
Score = 48.1 bits (113), Expect = 5e-05
Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 11/102 (10%)
Query: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
G +E+ E V L + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 456 GDDEITREPRKVVLHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 507
Query: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK-RPRK 121
+ DR++ VN + H A L+ +G+ IV + RP +
Sbjct: 508 KGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEE 549
Score = 37.0 bits (84), Expect = 0.11
Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
+ ++G+S +G +AGG +D IF+ I G +A Q+G L+ D IL+VN D
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
R + AV L E G +V + + R V I+
Sbjct: 285 RDVTHSKAVEALKE--AGSIVRLYVKRRKPVSEKIM 318
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 128 bits (322), Expect = 3e-29
Identities = 157/629 (24%), Positives = 250/629 (39%), Gaps = 138/629 (21%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
+ I++ ++ G A KDG L GD +L +N T +++ +A ++ + + L V +
Sbjct: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKP 312
Query: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
LND Y+ DY S+ L + S
Sbjct: 313 GSL------HLND------------------------MYAPPDYASTFTALADNHISHN- 341
Query: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEA 504
S L +GA + A VP T RY P P+ A F R
Sbjct: 342 --SSLGYLGAVESKVSYP---APPQVPPT----RYS---PIPRHMLAEEDFTREP----- 384
Query: 505 IYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQD 562
K++ K +G + GG D GIFV+ I G A+ G L+ GD+IL VN +
Sbjct: 385 -----RKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
Query: 563 FRGLVREDAVLYLLEIPKGEMVTILAQSRADVY---------------RDILACGRGD-- 605
R E A L G+ VTI+AQ R + Y ++ G G
Sbjct: 440 LRNATHEQAAAALKRA--GQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR 497
Query: 606 -----SFFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELE 655
S ++R+ F+ ++ Q L+F+ G++ V++ D L G +
Sbjct: 498 TSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQ 557
Query: 656 KGLIPNKSRAEQMASVQ------NAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAV 709
G+IP+K R E+ + +A+ DF + G K NL K +ED A+
Sbjct: 558 IGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAK-NL-KGQED--AI 613
Query: 710 VSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---- 762
+S YE V +E + RPV++ GP+ D + L +E P F + T P
Sbjct: 614 LS-------YEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDN 666
Query: 763 -----------------KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPK 796
KD K + N +VR + E+ KH +LDV+
Sbjct: 667 EVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGN 726
Query: 797 AVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTA 856
A+ L Q +PI IF P S + + M +R + + + K++D+A KL++ FTA
Sbjct: 727 AIKRLQQAQLYPIAIFIKPKSIEALMEMNRR---QTYEQANKIYDKAMKLEQEFGEYFTA 783
Query: 857 TINLNSANDSWFGSLKDTIQHQQGEAVWV 885
+ +S + + +K I+ Q G +WV
Sbjct: 784 IVQGDSLEEI-YNKIKQIIEDQSGHYIWV 811
Score = 63.2 bits (152), Expect = 1e-09
Identities = 34/90 (37%), Positives = 55/90 (61%), Gaps = 3/90 (3%)
Query: 31 QYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMV 88
+Y + + G G +++GG DNPH + + I I+ ++PGG A DG L ND V+ V
Sbjct: 128 KYEEIVLERGNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
Query: 89 NGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
N + +V+HS AV+ L+++G V +VV+R
Sbjct: 187 NEVDVSEVVHSRAVEALKEAGPVVRLVVRR 216
Score = 58.9 bits (141), Expect = 3e-08
Identities = 32/92 (34%), Positives = 52/92 (56%), Gaps = 3/92 (3%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
+G G +++GG N H G+ SI I+ ++ GG A DG LQ DR++ VN T ++DV H
Sbjct: 234 KGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHE 292
Query: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASP 131
AV L+ + + + V +P + + + A P
Sbjct: 293 EAVASLKNTSDMVYLKVAKPGSLHLNDMYAPP 324
Score = 48.5 bits (114), Expect = 4e-05
Identities = 35/100 (35%), Positives = 51/100 (51%), Gaps = 11/100 (11%)
Query: 25 EELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQEN 82
E+ E + L K S G G + GG D GE I +S +L GGPAD G L+
Sbjct: 378 EDFTREPRKIILHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELRRG 429
Query: 83 DRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK-RPRK 121
DR++ VNG + + H A L+++G+ IV + RP +
Sbjct: 430 DRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEE 469
Score = 36.6 bits (83), Expect = 0.15
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 12/87 (13%)
Query: 497 RPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG- 548
R P E I N +++ KG +G +AGG D I++ I EG +A+++G
Sbjct: 216 RRQPPPETIMEVN--LLKGPKG--LGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGR 271
Query: 549 LQEGDQILKVNTQDFRGLVREDAVLYL 575
LQ GD++L VN + + + E+AV L
Sbjct: 272 LQIGDRLLAVNNTNLQDVRHEEAVASL 298
Score = 32.3 bits (72), Expect = 2.8
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 4/108 (3%)
Query: 324 GSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
G IFV + G A G L GD IL +NG N + A ++++ + +V
Sbjct: 406 GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQY 465
Query: 384 DSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQY----SDYD 427
++ ++D ++ + S + S E+R Y DYD
Sbjct: 466 RPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYD 513
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 127 bits (318), Expect = 8e-29
Identities = 158/681 (23%), Positives = 280/681 (41%), Gaps = 131/681 (19%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
S IF+ ++ G A +DG L D IL++N +++ + A + ++++ ++L V R
Sbjct: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
Query: 385 S--QQTLINIPSLND------------------SDSEIEDISEIESNRSFSPEERRHQYS 424
+ ++ I + D+ I IE + ++ + Q
Sbjct: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH--KDGKLQIG 368
Query: 425 DYDYHSSSEKLKE-----RPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRY 479
D ++ L+E ++ ++T + A PT A + ++ +P
Sbjct: 369 DKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
Query: 480 QEDPPAPQPKAAPRTFLRPSPEDEAIYGPNT------KMVRFKKGDSVGLRLAGGND-VG 532
P+ P + R SP +A+ G + K+V + +G + GG D G
Sbjct: 429 NHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG 488
Query: 533 IFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSR 591
IF++ I G A+ G L++GD+I+ VN+ D R E A L G+ VTI+AQ R
Sbjct: 489 IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYR 546
Query: 592 ADVY---------------RDILACGRGD-------SFFIRSHFECEKETP-----QSLA 624
+ Y ++ G G S ++R+ F+ +K Q L
Sbjct: 547 PEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLN 606
Query: 625 FTRGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQ 675
F G++ V++ D W A ++ G E G+IP+K R E+ + N++
Sbjct: 607 FKFGDILHVINASDDEW---WQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSK 663
Query: 676 RDNAGDRADFWRMRG---QRSGVKKNLRKSRED-------LTAVVSVSTK--------FP 717
+ G + R + ++ KN +S ++ +T+ S S
Sbjct: 664 TRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVL 723
Query: 718 AYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEPK----------- 763
+YE V +E + RPV++ GP+ D + L +E PD F + T PK
Sbjct: 724 SYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYH 783
Query: 764 ----------DAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYT 804
D K + N +VR++ E+ KH +LDV+ A+ L
Sbjct: 784 FVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIA 843
Query: 805 QWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSAN 864
Q +PI IF P S + + M +RL + + +RK F++A KL++ FTA + ++
Sbjct: 844 QLYPISIFIKPKSMENIMEMNKRL---TEEQARKTFERAMKLEQEFTEHFTAIVQGDTLE 900
Query: 865 DSWFGSLKDTIQHQQGEAVWV 885
D + +K I+ Q G +WV
Sbjct: 901 DI-YNQVKQIIEEQSGSYIWV 920
Score = 67.4 bits (163), Expect = 8e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 4/96 (4%)
Query: 29 WEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVV 86
+E +TL++ + G G +++GG DNPH + ++SI I+ ++ GG A DG L+ ND ++
Sbjct: 220 YEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DSSIFITKIITGGAAAQDGRLRVNDCIL 277
Query: 87 MVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
VN + DV HS AV+ L+++G + + VKR + V
Sbjct: 278 RVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Score = 52.0 bits (123), Expect = 3e-06
Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 3/94 (3%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +E+V H
Sbjct: 327 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHE 385
Query: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
AV L+ + + V +P + + A P +
Sbjct: 386 EAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
Score = 48.1 bits (113), Expect = 5e-05
Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 11/102 (10%)
Query: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
G +E+ E V L + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 456 GDDEITREPRKVVLHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 507
Query: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK-RPRK 121
+ DR++ VN + H A L+ +G+ IV + RP +
Sbjct: 508 KGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEE 549
Score = 37.0 bits (84), Expect = 0.11
Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
+ ++G+S +G +AGG +D IF+ I G +A Q+G L+ D IL+VN D
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
R + AV L E G +V + + R V I+
Sbjct: 285 RDVTHSKAVEALKE--AGSIVRLYVKRRKPVSEKIM 318
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 125 bits (314), Expect = 2e-28
Identities = 158/628 (25%), Positives = 253/628 (40%), Gaps = 163/628 (25%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
+ I+V ++ G A KDG L GD IL +N E++ DA ++ + + L V +
Sbjct: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 289
Query: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
S L + S++P + YS + ++ D
Sbjct: 290 SNAYLSD---------------------SYAPPDITTSYSQH----LDNEISHSSYLGTD 324
Query: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETN--KEPRYQEDPPAPQPKAAPRTFLRPSPED 502
P+ + TPT + +A ++ E + +EPR
Sbjct: 325 YPTAM-----TPTSPRRYSPVAKDLLGEEDIPREPR------------------------ 355
Query: 503 EAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNT 560
++V + +G + GG D GIF++ I G A+ G L++GDQIL VN
Sbjct: 356 --------RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 407
Query: 561 QDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA-------------CGRGDS- 606
D R E A + L G+ VTI+AQ + + Y A G G +
Sbjct: 408 VDLRNASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTAS 465
Query: 607 --------FFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNE 653
F+IR+ F+ +K Q+L+F G+V V+D + W A R+ ++
Sbjct: 466 LRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSD 522
Query: 654 LEK---GLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVV 710
E G IP+K R E+ R+ + +A W G SG + RED +V+
Sbjct: 523 SETDDIGFIPSKRRVER--------REWSRLKAKDW---GSSSG-----SQGRED--SVL 564
Query: 711 SVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEPK---- 763
S YE V E + RP+++ GP D A + L +E PD F + T PK
Sbjct: 565 S-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYE 617
Query: 764 -------------------------DAGSEKS-TGVVRLNTVRQIIEQDKHALLDVTPKA 797
+AG S + +VR++ EQ KH +LDV+ A
Sbjct: 618 IDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANA 677
Query: 798 VDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTAT 857
V L PI IF P S + V + +R+ + + +RK FD+A KL++ F+A
Sbjct: 678 VRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATKLEQEFTECFSAI 734
Query: 858 INLNSANDSWFGSLKDTIQHQQGEAVWV 885
+ +S + + +K I+ G +WV
Sbjct: 735 VEGDSFEEI-YHKVKRVIEDLSGPYIWV 761
Score = 67.8 bits (164), Expect = 6e-11
Identities = 41/117 (35%), Positives = 66/117 (56%), Gaps = 10/117 (8%)
Query: 10 PPRRELSGWLRAPGMEELI------WEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETS 63
PP + L APG E + E +TL++ + G G +++GG DNPH + + S
Sbjct: 79 PPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DPS 136
Query: 64 IVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
I I+ ++PGG A DG L+ ND ++ VN + +V HS AV+ L+++G + + V R
Sbjct: 137 IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMR 193
Score = 58.2 bits (139), Expect = 5e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +EDV+H
Sbjct: 211 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHE 269
Query: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
AV L+ + V + V +P ++ A P +
Sbjct: 270 DAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDI 303
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
G E++ E + + + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 346 GEEDIPREPRRIVIHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 397
Query: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
+ D+++ VNG + + H A L+ +G+ I+ +
Sbjct: 398 KGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Score = 40.0 bits (92), Expect = 0.013
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 12/88 (13%)
Query: 496 LRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG 548
+R P E + K+++ KG +G +AGG D I+V I EG +A ++G
Sbjct: 192 MRRKPPAEKVM--EIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 247
Query: 549 -LQEGDQILKVNTQDFRGLVREDAVLYL 575
LQ GD+IL VN+ ++ EDAV L
Sbjct: 248 RLQIGDKILAVNSVGLEDVMHEDAVAAL 275
Score = 33.1 bits (74), Expect = 1.6
Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 11/88 (12%)
Query: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
+ ++G+S +G +AGG +D IF+ I G +A Q+G L+ D IL VN D
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Query: 564 RGLVREDAVLYLLEIPKGEMVTILAQSR 591
R + AV L E G +V + R
Sbjct: 169 REVTHSAAVEALKE--AGSIVRLYVMRR 194
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 125 bits (314), Expect = 2e-28
Identities = 158/628 (25%), Positives = 253/628 (40%), Gaps = 163/628 (25%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
+ I+V ++ G A KDG L GD IL +N E++ DA ++ + + L V +
Sbjct: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 243
Query: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
S L + S++P + YS + ++ D
Sbjct: 244 SNAYLSD---------------------SYAPPDITTSYSQH----LDNEISHSSYLGTD 278
Query: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETN--KEPRYQEDPPAPQPKAAPRTFLRPSPED 502
P+ + TPT + +A ++ E + +EPR
Sbjct: 279 YPTAM-----TPTSPRRYSPVAKDLLGEEDIPREPR------------------------ 309
Query: 503 EAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNT 560
++V + +G + GG D GIF++ I G A+ G L++GDQIL VN
Sbjct: 310 --------RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 361
Query: 561 QDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA-------------CGRGDS- 606
D R E A + L G+ VTI+AQ + + Y A G G +
Sbjct: 362 VDLRNASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTAS 419
Query: 607 --------FFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNE 653
F+IR+ F+ +K Q+L+F G+V V+D + W A R+ ++
Sbjct: 420 LRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSD 476
Query: 654 LEK---GLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVV 710
E G IP+K R E+ R+ + +A W G SG + RED +V+
Sbjct: 477 SETDDIGFIPSKRRVER--------REWSRLKAKDW---GSSSG-----SQGRED--SVL 518
Query: 711 SVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEPK---- 763
S YE V E + RP+++ GP D A + L +E PD F + T PK
Sbjct: 519 S-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYE 571
Query: 764 -------------------------DAGSEKS-TGVVRLNTVRQIIEQDKHALLDVTPKA 797
+AG S + +VR++ EQ KH +LDV+ A
Sbjct: 572 IDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANA 631
Query: 798 VDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTAT 857
V L PI IF P S + V + +R+ + + +RK FD+A KL++ F+A
Sbjct: 632 VRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATKLEQEFTECFSAI 688
Query: 858 INLNSANDSWFGSLKDTIQHQQGEAVWV 885
+ +S + + +K I+ G +WV
Sbjct: 689 VEGDSFEEI-YHKVKRVIEDLSGPYIWV 715
Score = 66.6 bits (161), Expect = 1e-10
Identities = 41/114 (35%), Positives = 65/114 (57%), Gaps = 7/114 (6%)
Query: 10 PPRRELSGWLRAPGM---EELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVI 66
PP + L APG E E +TL++ + G G +++GG DNPH + + SI I
Sbjct: 36 PPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DPSIFI 93
Query: 67 SDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
+ ++PGG A DG L+ ND ++ VN + +V HS AV+ L+++G + + V R
Sbjct: 94 TKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMR 147
Score = 58.2 bits (139), Expect = 5e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +EDV+H
Sbjct: 165 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHE 223
Query: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
AV L+ + V + V +P ++ A P +
Sbjct: 224 DAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDI 257
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
G E++ E + + + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 300 GEEDIPREPRRIVIHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 351
Query: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
+ D+++ VNG + + H A L+ +G+ I+ +
Sbjct: 352 KGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
Score = 40.0 bits (92), Expect = 0.013
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 12/88 (13%)
Query: 496 LRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG 548
+R P E + K+++ KG +G +AGG D I+V I EG +A ++G
Sbjct: 146 MRRKPPAEKVM--EIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 201
Query: 549 -LQEGDQILKVNTQDFRGLVREDAVLYL 575
LQ GD+IL VN+ ++ EDAV L
Sbjct: 202 RLQIGDKILAVNSVGLEDVMHEDAVAAL 229
Score = 33.5 bits (75), Expect = 1.2
Identities = 40/143 (27%), Positives = 61/143 (42%), Gaps = 26/143 (18%)
Query: 473 TNKEPRYQED--PPA-------PQPKAAPRTFLRPSPEDEAIYGPNTK------MVRFKK 517
T K+ RYQ++ PP P +P + + Y T+ + ++
Sbjct: 8 TTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLER 67
Query: 518 GDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVR 568
G+S +G +AGG +D IF+ I G +A Q+G L+ D IL VN D R +
Sbjct: 68 GNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127
Query: 569 EDAVLYLLEIPKGEMVTILAQSR 591
AV L E G +V + R
Sbjct: 128 SAAVEALKE--AGSIVRLYVMRR 148
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 112 bits (279), Expect = 3e-24
Identities = 121/490 (24%), Positives = 196/490 (40%), Gaps = 99/490 (20%)
Query: 485 APQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTS 543
A Q A P LRP + K++ K +G + GG D GIFV+ I G
Sbjct: 27 ASQRWAWPLRSLRPGGDARE----PRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGP 82
Query: 544 AEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVY------- 595
A+ G L+ GD+IL VN + R E A L G+ VTI+AQ R + Y
Sbjct: 83 ADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA--GQSVTIVAQYRPEEYSRFESKI 140
Query: 596 --------RDILACGRGD-------SFFIRSHFECEKETP-----QSLAFTRGEVFRVVD 635
++ G G S ++R+ F+ ++ Q L+F+ G++ V++
Sbjct: 141 HDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN 200
Query: 636 TLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGV 695
D L G + G+IP+K R E+ + R ++
Sbjct: 201 ASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKR 260
Query: 696 KKNLR--------KSREDLTAVVSVSTK-------------------FPAYERVLLREAG 728
KK+ R KS+E++ S+ + +YE V +E
Sbjct: 261 KKSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIH 320
Query: 729 FKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---------------------KD 764
+ RPV++ GP+ D + L +E P F + T P KD
Sbjct: 321 YARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKD 380
Query: 765 AGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNP 815
K + N +VR + E+ KH +LDV+ A+ L Q +PI IF P
Sbjct: 381 IQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKP 440
Query: 816 DSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTI 875
S + + M +R + + + K++D+A KL++ FTA + +S + + +K I
Sbjct: 441 KSIEALMEMNRR---QTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEI-YNKIKQII 496
Query: 876 QHQQGEAVWV 885
+ Q G +WV
Sbjct: 497 EDQSGHYIWV 506
Score = 47.4 bits (111), Expect = 8e-05
Identities = 34/95 (35%), Positives = 49/95 (51%), Gaps = 11/95 (11%)
Query: 30 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87
E + L K S G G + GG D GE I +S +L GGPAD G L+ DR++
Sbjct: 46 EPRKIILHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELRRGDRILS 97
Query: 88 VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK-RPRK 121
VNG + + H A L+++G+ IV + RP +
Sbjct: 98 VNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEE 132
Score = 32.3 bits (72), Expect = 2.8
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 4/108 (3%)
Query: 324 GSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
G IFV + G A G L GD IL +NG N + A ++++ + +V
Sbjct: 69 GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQY 128
Query: 384 DSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQY----SDYD 427
++ ++D ++ + S + S E+R Y DYD
Sbjct: 129 RPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYD 176
>gi|169160873 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 91.7 bits (226), Expect = 4e-18
Identities = 62/177 (35%), Positives = 92/177 (51%), Gaps = 30/177 (16%)
Query: 828 LNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSE 887
L P S +S+R+L+ QA KL+K +HLFTATI LN +D+W+ K I+ QQ +W +E
Sbjct: 21 LAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTAE 80
Query: 888 GKMEG-MDDDPEDRMSYLTAMGADYLSCDSRLISDF---------------EDTDGEGGA 931
K++G ++D+P ++ +A LSCDSR+ SD+ GG
Sbjct: 81 DKLDGSLEDNPHRGLADSSA----DLSCDSRVNSDYWRRRKARAARTLMASATQTASGGP 136
Query: 932 YTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPP 988
YTD + + PA ++ RSSEPVQ +E PR + R +A D+ P
Sbjct: 137 YTDADDELPA-----PALDRSSEPVQADE-----PQSPRVRGRISAHQGPQVDSPHP 183
>gi|239747400 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 91.7 bits (226), Expect = 4e-18
Identities = 62/177 (35%), Positives = 92/177 (51%), Gaps = 30/177 (16%)
Query: 828 LNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSE 887
L P S +S+R+L+ QA KL+K +HLFTATI LN +D+W+ K I+ QQ +W +E
Sbjct: 21 LAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTAE 80
Query: 888 GKMEG-MDDDPEDRMSYLTAMGADYLSCDSRLISDF---------------EDTDGEGGA 931
K++G ++D+P ++ +A LSCDSR+ SD+ GG
Sbjct: 81 DKLDGSLEDNPHRGLADSSA----DLSCDSRVNSDYWRRRKARAARTLMASATQTASGGP 136
Query: 932 YTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPP 988
YTD + + PA ++ RSSEPVQ +E PR + R +A D+ P
Sbjct: 137 YTDADDELPA-----PALDRSSEPVQADE-----PQSPRVRGRISAHQGPQVDSPHP 183
>gi|239741226 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 91.7 bits (226), Expect = 4e-18
Identities = 62/177 (35%), Positives = 92/177 (51%), Gaps = 30/177 (16%)
Query: 828 LNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSE 887
L P S +S+R+L+ QA KL+K +HLFTATI LN +D+W+ K I+ QQ +W +E
Sbjct: 21 LAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTAE 80
Query: 888 GKMEG-MDDDPEDRMSYLTAMGADYLSCDSRLISDF---------------EDTDGEGGA 931
K++G ++D+P ++ +A LSCDSR+ SD+ GG
Sbjct: 81 DKLDGSLEDNPHRGLADSSA----DLSCDSRVNSDYWRRRKARAARTLMASATQTASGGP 136
Query: 932 YTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPP 988
YTD + + PA ++ RSSEPVQ +E PR + R +A D+ P
Sbjct: 137 YTDADDELPA-----PALDRSSEPVQADE-----PQSPRVRGRISAHQGPQVDSPHP 183
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 91.3 bits (225), Expect = 5e-18
Identities = 84/327 (25%), Positives = 140/327 (42%), Gaps = 65/327 (19%)
Query: 606 SFFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRI---GNELEKG 657
S ++R+ F+ +K Q L+F G++ V++ D W A R+ G+ E G
Sbjct: 20 SLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEEMG 76
Query: 658 LIPNKSRAEQMASVQ------NAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVS 711
+IP+K R E+ + NA+ + D + G K + +EDL
Sbjct: 77 VIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKT--LRGQEDLIL--- 131
Query: 712 VSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEPK----- 763
+YE V +E + RPV++ GP+ D + L +E PD F + T PK
Sbjct: 132 ------SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEV 185
Query: 764 ----------------DAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAV 798
D K + N +VR + E+ KH +LDV+ A+
Sbjct: 186 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 245
Query: 799 DLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATI 858
L Q +PI IF P S + + M +RL + + ++K +D+A KL++ FTA +
Sbjct: 246 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIV 302
Query: 859 NLNSANDSWFGSLKDTIQHQQGEAVWV 885
++ D + K I+ Q G +W+
Sbjct: 303 QGDTLEDI-YNQCKLVIEEQSGPFIWI 328
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 79.3 bits (194), Expect = 2e-14
Identities = 62/170 (36%), Positives = 82/170 (48%), Gaps = 23/170 (13%)
Query: 152 RSGYSERSRLNSHGGRS---RSWEDSPERGRPHERARS----RERDLSR------DRSRG 198
RS ER S R RS SP + R H R+RS R+R SR DRSR
Sbjct: 369 RSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRS 428
Query: 199 RSLERGLDQDHART----RDRSRGRSLERGLDHDFG--PSRDRDRDRSRGRSIDQDYERA 252
RS + D +R+ RDRSR RS + DH P++ RDR RSR S ++D+ +
Sbjct: 429 RSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQL 488
Query: 253 YHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGR 302
+ + D+ R+ SP R R S S+ R+H SRSPS E + R
Sbjct: 489 GSPSKERDHRRSRSPSKERQCRQSRSS----SKERDHRRSRSPSKERQRR 534
Score = 76.3 bits (186), Expect = 2e-13
Identities = 69/212 (32%), Positives = 97/212 (45%), Gaps = 32/212 (15%)
Query: 117 KRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHG-----GRSRSW 171
+ P K + + S ++D R + GRS +SG + R +S R RS
Sbjct: 357 RNPSKERSHSHSRSSSKERDHRGSSSPRKESGRS-QSGSPNKQRDHSRSRSPNKARDRSR 415
Query: 172 EDSPERGRPHERARS--RERDLSR--------DRSRGRSLERGLDQDHART----RDRSR 217
SP + R R+RS + RD SR DRSR RS + D +R+ RDRSR
Sbjct: 416 SRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSR 475
Query: 218 GRSLERGLDHDF--GPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARH 275
RS + DH PS++RD RSR S ++ ++ + + D+ R+ SP R R
Sbjct: 476 SRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQ 535
Query: 276 D---------ARSRGPRSRSREHPHSRSPSPE 298
++SR P S REH SRSPS E
Sbjct: 536 SRSPNKERDRSQSRSP-SEEREHRQSRSPSKE 566
Score = 67.4 bits (163), Expect = 8e-11
Identities = 62/217 (28%), Positives = 88/217 (40%), Gaps = 38/217 (17%)
Query: 119 PRKVQVAALQASPPLDQDDRAFEVMDEFDGRS-FRSGYSERSRLNSHG------------ 165
PRK + SP +D ++ RS RS Y R R S
Sbjct: 383 PRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRS 442
Query: 166 ---GRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLER--------GLDQDHARTRD 214
R RS SP + R H R+RS + R RSR S ER ++DH R+R
Sbjct: 443 PYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRS 502
Query: 215 --------RSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYS 266
+SR S ER PS++R R +SR + ++D ++ + + ++ ++ S
Sbjct: 503 PSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRS 562
Query: 267 PEYRRGARH------DARSRGPRSRSREHPHSRSPSP 297
P R R + R RS S E HSRS SP
Sbjct: 563 PSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSP 599
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 8/135 (5%)
Query: 169 RSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDH- 227
RS S ER R+ S+ERD R RS + +R + + RDRS+ RS +H
Sbjct: 499 RSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHR 558
Query: 228 -DFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRS 286
PS++RDR R R S +++ ++ + + D+ R+ SP + G PR+ S
Sbjct: 559 QSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSR------PRASS 612
Query: 287 REHPHSRSPSPEPRG 301
+E HSRS +P G
Sbjct: 613 KEKAHSRSRTPSKEG 627
Score = 60.5 bits (145), Expect = 9e-09
Identities = 95/387 (24%), Positives = 147/387 (37%), Gaps = 61/387 (15%)
Query: 153 SGYSERSRLNSHG-GRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHAR 211
S S+ SH G+S++ +P RGR H +R+ ++ S SR S ER DH
Sbjct: 324 SQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKER----DH-- 377
Query: 212 TRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRR 271
R S R E G P++ RD RSR + +D R+ D R+ SP R
Sbjct: 378 -RGSSSPRK-ESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKAR 435
Query: 272 G---------ARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLR 322
AR +RSR P +++R+H SRSP+ + R R +S + E +
Sbjct: 436 DCSRSRSPYKARDRSRSRSP-NKARDHSRSRSPN-KARDRS------RSRSPSKERDHSQ 487
Query: 323 LGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVL 382
LGS ++ R+ +K+ + K + ++ +S K
Sbjct: 488 LGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNK-----E 542
Query: 383 RDSQQTLINIPSLNDSDSEIEDISEIESNRSF--------------SPEERRHQYS---- 424
RD Q+ PS + S+ R + S EER H S
Sbjct: 543 RDRSQS--RSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPN 600
Query: 425 -DYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDP 483
Y KE+ SR TPS+ + T K + D + + VP + P ++ P
Sbjct: 601 KQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKES-DPSQSTVP---RSPDWKRSP 656
Query: 484 PAPQPKAAPRTFLRPSPEDEAIYGPNT 510
+ RT P + + P+T
Sbjct: 657 TRTSSLSQNRT-----PSKTSSHSPST 678
Score = 55.5 bits (132), Expect = 3e-07
Identities = 48/163 (29%), Positives = 73/163 (44%), Gaps = 10/163 (6%)
Query: 145 EFDGRSFRSGYSERSRLNSHGG---RSRSWEDSPERGRPHERARS--RERDLSRDRSRGR 199
E D R RS ER R S R RS SP R H ++RS +ERD R RS +
Sbjct: 518 ERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSK 577
Query: 200 SLERGLDQDHARTRDRSRGRS--LERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAY 257
ER + + RD SR RS + G S+++ RSR S + ++ ++ +
Sbjct: 578 ERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSK 637
Query: 258 DPDYERA---YSPEYRRGARHDARSRGPRSRSREHPHSRSPSP 297
+ D ++ SP+++R + R+ S+ HS S P
Sbjct: 638 ESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFP 680
Score = 51.6 bits (122), Expect = 4e-06
Identities = 42/152 (27%), Positives = 71/152 (46%), Gaps = 17/152 (11%)
Query: 156 SERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLER----------GL 205
S RSR SH +SRS S + +R R R+ SR RS R
Sbjct: 273 STRSRPQSHS-QSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQ 331
Query: 206 DQDHARTRDRSRGRSLERGLDHDF--GPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYER 263
+ H++ + +++ R+ RG H++ PS++R SR S ++D+ + + +
Sbjct: 332 SRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQ 391
Query: 264 AYSPEYRRGARHDARSRGPRSRSREHPHSRSP 295
+ SP + R +RSR P +++R+ SRSP
Sbjct: 392 SGSPNKQ---RDHSRSRSP-NKARDRSRSRSP 419
Score = 47.4 bits (111), Expect = 8e-05
Identities = 75/345 (21%), Positives = 130/345 (37%), Gaps = 37/345 (10%)
Query: 167 RSRSWEDSPERGRPHERARS----RERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLE 222
R +S+ + R RP ++S R R S+ R+ R ++H+R R R+R L
Sbjct: 265 RVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILS 324
Query: 223 RGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGP 282
+ H SR + +S+ +S R+++ + +P ER++S + R + + RG
Sbjct: 325 QMGRH--SQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHS--HSRSSSKERDHRGS 380
Query: 283 RSRSREHPHSRSPSPEPR---GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLAT 339
S +E S+S SP + R +SR+ Y R S+ R +
Sbjct: 381 SSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRS 440
Query: 340 KDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSD 399
+ + ++ K ++SR + PS
Sbjct: 441 RSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSR---------------SPSKERDH 485
Query: 400 SEIEDIS-EIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTP 458
S++ S E + RS SP + R S KER R +PS+ + + +P
Sbjct: 486 SQLGSPSKERDHRRSRSPSKER------QCRQSRSSSKERDHRRSRSPSKERQRRQSRSP 539
Query: 459 FKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDE 503
K D + + P +E R P + + R + PS E E
Sbjct: 540 NKER-DRSQSRSPSEEREHRQSRSPSKERDR---RRWRSPSKERE 580
Score = 42.7 bits (99), Expect = 0.002
Identities = 31/132 (23%), Positives = 51/132 (38%)
Query: 174 SPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSR 233
S E+ SR + ++ +R R + R+R S+ R+ R H + +
Sbjct: 252 SREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNH 311
Query: 234 DRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSR 293
R R R+R + Q + R++ + S RRG H+ + RS H S
Sbjct: 312 SRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSS 371
Query: 294 SPSPEPRGRPGP 305
S + RG P
Sbjct: 372 SKERDHRGSSSP 383
Score = 36.6 bits (83), Expect = 0.15
Identities = 72/320 (22%), Positives = 113/320 (35%), Gaps = 51/320 (15%)
Query: 156 SERSRLNSHGGRS--RSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTR 213
S R+ +HG R S +P + R +S R + +R R S R L + R
Sbjct: 140 STPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPP 199
Query: 214 DRSR-GRSLERGLDHDFG--------PSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERA 264
S GRS E + PS+++ + S S ++Y + P E++
Sbjct: 200 GGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKV---KSYGQMIIPSREKS 256
Query: 265 YSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLG 324
YSP RSR + H SRSP R R G + + R+
Sbjct: 257 YSPTEMSSRVKSYNQASTRSRPQSHSQSRSPR---RSRSG----------SQKRTHSRVR 303
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQ---LVV 381
S + + +R T+ G IL G +++ S S+GK Q
Sbjct: 304 SHSWKRNHSRARSRTRKG-------ILSQMGRHSQSRS---------HSKGKSQNQSRTP 347
Query: 382 LRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSS 441
R PS S S S+ +R S + S S K+R S
Sbjct: 348 RRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRS-----QSGSPNKQRDHS 402
Query: 442 REDTPSRLSRMGATPTPFKS 461
R +P++ + +P+K+
Sbjct: 403 RSRSPNKARDRSRSRSPYKA 422
Score = 34.3 bits (77), Expect = 0.72
Identities = 40/233 (17%), Positives = 88/233 (37%), Gaps = 13/233 (5%)
Query: 952 SSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSK 1011
SS P + + SP + R+ S ++ RD S P KA+ +++ S + ++
Sbjct: 380 SSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSR----SRSPYKARDRSRSRSPNKAR 435
Query: 1012 SYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQ 1071
+P + K + P R + +P ++ ++G S+E+
Sbjct: 436 DCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKER 495
Query: 1072 DNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGT 1131
D+ K + + ++ + + + R + P+ ++ P
Sbjct: 496 DHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSE-E 554
Query: 1132 PQHTSSRPPEPQ------KAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGY 1178
+H SR P + ++PS+ + R S +EE ++ + S + + GY
Sbjct: 555 REHRQSRSPSKERDRRRWRSPSK--ERERRQSRSSSEERDHSRSRSPNKQSGY 605
Score = 30.8 bits (68), Expect = 8.0
Identities = 43/213 (20%), Positives = 83/213 (38%), Gaps = 37/213 (17%)
Query: 940 PAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAK 999
P++E S + S+ H S R PS E + + R++S ++ S P+ + + +++
Sbjct: 479 PSKERDHSQLGSPSKERDHRRS-RSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSR 537
Query: 1000 TQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQ 1059
+ NKE S+S PS + + P+ R + +P +
Sbjct: 538 SPNKERDRSQSRS------PSEEREHRQ------------SRSPSKERDRRRWRSPSKER 579
Query: 1060 EGEEVGESSEEQDN----APKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHP 1115
E + SSEE+D+ +P G + KA + +E +++ + K
Sbjct: 580 ERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKES 639
Query: 1116 DIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSR 1148
D Q T R P+ +++P+R
Sbjct: 640 D--------------PSQSTVPRSPDWKRSPTR 658
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 75.9 bits (185), Expect = 2e-13
Identities = 78/329 (23%), Positives = 128/329 (38%), Gaps = 14/329 (4%)
Query: 157 ERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRS 216
ER R R E ER R E+ + RER+ RDR R R+ ER D+D R RDR
Sbjct: 311 ERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRD 370
Query: 217 RGRSLERGLDHDFG--PSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGAR 274
R RS +R D SRDR+R+R R R +++ ER R + + ER E + +
Sbjct: 371 RERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKK 430
Query: 275 HDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQ-----IFV 329
D + R + E + + + + EY +
Sbjct: 431 RDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMA 490
Query: 330 KEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTL 389
KE R +D + D + + + + ++ K + L + +Q L
Sbjct: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRL 550
Query: 390 INIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEK--LKERPSSREDTPS 447
+ D D+E++ + E E+ R P+ ++ S+ + EK +E P E+ P
Sbjct: 551 L-AEGHPDPDAELQRM-EQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPE 608
Query: 448 RLSRMGATPTPFKSTGDI---AGTVVPET 473
+ + T P S + +G P T
Sbjct: 609 QKPCLKPTLRPISSAPSVSSASGNATPNT 637
Score = 72.8 bits (177), Expect = 2e-12
Identities = 58/183 (31%), Positives = 80/183 (43%), Gaps = 14/183 (7%)
Query: 120 RKVQVAALQASPPLDQDDRAFEVMDEFDGRS--------FRSGYSERSRLNSHGGRSRSW 171
R+ VA L P + ++D M+E D R FR + + + R
Sbjct: 246 RRFPVAPLIPYPLITKEDINAIEMEE-DKRDLISREISKFRDTHKKLEEEKGKKEKERQE 304
Query: 172 EDSPERGRPHERARSRER-DLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFG 230
+ R R ER R RER + R+R R R E+ +++ R RDR R R+ ER D D
Sbjct: 305 IEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRD-- 362
Query: 231 PSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHP 290
R+RDRDR R RS D++ +R+ R D ER E R + R R RE
Sbjct: 363 --RERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERE 420
Query: 291 HSR 293
R
Sbjct: 421 RER 423
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 75.1 bits (183), Expect = 4e-13
Identities = 87/388 (22%), Positives = 154/388 (39%), Gaps = 53/388 (13%)
Query: 34 VTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVMVNGT 91
V L+KD+K G G + GG + G I IS V PGGPAD G L+ DR++ VN
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLG---IFISSVAPGGPADLDGCLKPGDRLISVNSV 1150
Query: 92 PMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSF 151
+E V H A++ L+ + + +V+ +P K +++ + ++P + +E
Sbjct: 1151 SLEGVSHHAAIEILQNAPEDVTLVISQP-KEKISKVPSTP--------VHLTNEMKNYMK 1201
Query: 152 RSGYSERSRLNSHGGRSRSWEDSPER----------GRPHERARSRERDLSRDRSRGRSL 201
+S Y + S ++S + W R G E + S + + S +S
Sbjct: 1202 KSSYMQDSAIDS-SSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQ 1260
Query: 202 ERGLDQDHA--RTRDRSRGRS-----LERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYH 254
G H +T S+ S + + + + ++ + + G S DY
Sbjct: 1261 VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1320
Query: 255 RAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGP--------- 305
D E YS S + ++ + + S SP +PG
Sbjct: 1321 SDMD---EATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPP---KPGDIFEVELAKN 1374
Query: 306 -----IGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN 360
I V ++ + +R G I+VK + G A DG +H+GD +L +NG E
Sbjct: 1375 DNSLGISVTVLFDKGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1433
Query: 361 MSLTDARKLIEKSRGKLQLVVLRDSQQT 388
+ A + + + + L++ + T
Sbjct: 1434 ATHKQAVETLRNTGQVVHLLLEKGQSPT 1461
Score = 42.4 bits (98), Expect = 0.003
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 12/118 (10%)
Query: 2 PVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGE 61
P R + P + +L L +E + +TL K K G V+ G N
Sbjct: 1766 PTRQENWTPLKNDLENHLEDFELEV----ELLITLIKSEKGSLGFTVTKG-------NQR 1814
Query: 62 TSIVISDVLPG-GPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
+ DV+ +DG L+ DR++ VN T + ++ H+ AV LR + K +V+ R
Sbjct: 1815 IGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1872
Score = 39.7 bits (91), Expect = 0.017
Identities = 52/228 (22%), Positives = 92/228 (40%), Gaps = 54/228 (23%)
Query: 375 GKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEK 434
GK + R ++L + LN+S S ++ + SPE R+H
Sbjct: 1001 GKPSHQMSRSDAESLAGVTKLNNSKSV--------ASLNRSPERRKH------------- 1039
Query: 435 LKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRT 494
E SS + P + +G T S+G+ + V P R
Sbjct: 1040 --ESDSSSIEDPGQAYVLGMT---MHSSGNSSSQV-------------PLKENDVLHKRW 1081
Query: 495 FLRPSPEDEAIYGPNTKMVRFKKGDSVGL--RLAGGN-----DVGIFVAGIQEGTSAEQE 547
+ SPE E +V KK GL ++ GG D+GIF++ + G A+ +
Sbjct: 1082 SIVSSPEREIT------LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLD 1135
Query: 548 G-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADV 594
G L+ GD+++ VN+ G+ A+ L P+ ++ +++Q + +
Sbjct: 1136 GCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPE-DVTLVISQPKEKI 1182
Score = 37.4 bits (85), Expect = 0.086
Identities = 63/325 (19%), Positives = 117/325 (36%), Gaps = 79/325 (24%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
S + VK++ A + G + GD+ILK+NG + +S + + + ++ L++ R
Sbjct: 1534 SIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRP 1593
Query: 385 SQQTLINIPS-------------------------LNDSDSEIEDISEIESNRSFSPEER 419
L I + + S S E+ +S + R
Sbjct: 1594 PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1653
Query: 420 RHQYSDYDYHSSSEKLKERPSS----------REDTPSRLSRMGATPTPFKSTGDIAGTV 469
R YSD S + L P++ + + +S+ + KS D T+
Sbjct: 1654 RDSYSDSS-GSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM 1712
Query: 470 VPETNK---EPRYQEDPPAP-QPKAAPRTFLRPSPEDEA-----------IYGPNTK--- 511
K +P +++ P+P P AP +P E + I P +
Sbjct: 1713 FYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENW 1772
Query: 512 -----------------------MVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQE 547
+++ +KG S+G + GN +G +V + + +
Sbjct: 1773 TPLKNDLENHLEDFELEVELLITLIKSEKG-SLGFTVTKGNQRIGCYVHDVIQDPAKSDG 1831
Query: 548 GLQEGDQILKVNTQDFRGLVREDAV 572
L+ GD+++KVN D + DAV
Sbjct: 1832 RLKPGDRLIKVNDTDVTNMTHTDAV 1856
Score = 35.8 bits (81), Expect = 0.25
Identities = 18/46 (39%), Positives = 27/46 (58%)
Query: 338 ATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
A DG L GD ++K+N T NM+ TDA L+ + ++LV+ R
Sbjct: 1827 AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1872
Score = 35.0 bits (79), Expect = 0.42
Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQ 386
+++ ++ +A +GNL D+I +NG T+ M+L + + ++ S L +VL+ ++
Sbjct: 1913 VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS---LPSLVLKATR 1969
Query: 387 QTLINIPSLNDSDSEIEDISEIESNRSFS 415
L +PS S + + N S+S
Sbjct: 1970 NDLPVVPS--SKRSAVSAPKSTKGNGSYS 1996
Score = 32.0 bits (71), Expect = 3.6
Identities = 23/98 (23%), Positives = 46/98 (46%), Gaps = 12/98 (12%)
Query: 308 VLLMKSRANEEYGL-----------RLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGT 356
+ L+ + + +YGL RL IF+ + G A DG L GD ++ +N
Sbjct: 1091 ITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 1150
Query: 357 VTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPS 394
E +S A ++++ + + LV+ + ++ + +PS
Sbjct: 1151 SLEGVSHHAAIEILQNAPEDVTLVISQPKEK-ISKVPS 1187
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 75.1 bits (183), Expect = 4e-13
Identities = 87/383 (22%), Positives = 153/383 (39%), Gaps = 48/383 (12%)
Query: 34 VTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVMVNGT 91
V L+KD+K G G + GG + G I IS V PGGPAD G L+ DR++ VN
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLG---IFISSVAPGGPADLDGCLKPGDRLISVNSV 959
Query: 92 PMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSF 151
+E V H A++ L+ + + +V+ +P K +++ + ++P + +E
Sbjct: 960 SLEGVSHHAAIEILQNAPEDVTLVISQP-KEKISKVPSTP--------VHLTNEMKNYMK 1010
Query: 152 RSGYSERSRLNSHGGRSRSWEDSPER----------GRPHERARSRERDLSRDRSRGRSL 201
+S Y + S ++S + W R G E + S + + S +S
Sbjct: 1011 KSSYMQDSAIDS-SSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQ 1069
Query: 202 ERGLDQDHA--RTRDRSRGRS-----LERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYH 254
G H +T S+ S + + + + ++ + + G S DY
Sbjct: 1070 VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1129
Query: 255 RAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSR 314
D E YS S + ++ + + S SP +PG I + +
Sbjct: 1130 SDMD---EATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPP---KPGDIFEVELAKN 1183
Query: 315 ANE---------EYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTD 365
N +R G I+VK + G A DG +H+GD +L +NG E +
Sbjct: 1184 DNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQ 1242
Query: 366 ARKLIEKSRGKLQLVVLRDSQQT 388
A + + + + L++ + T
Sbjct: 1243 AVETLRNTGQVVHLLLEKGQSPT 1265
Score = 47.8 bits (112), Expect = 6e-05
Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 6/89 (6%)
Query: 32 YTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVN 89
+ V L K+ GI+V+GG + G I + V+P G A DG + + DRV+ VN
Sbjct: 1176 FEVELAKNDN-SLGISVTGGVNTSVRHGG---IYVKAVIPQGAAESDGRIHKGDRVLAVN 1231
Query: 90 GTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
G +E H AV+ LR +G+V +++++
Sbjct: 1232 GVSLEGATHKQAVETLRNTGQVVHLLLEK 1260
Score = 42.4 bits (98), Expect = 0.003
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 12/118 (10%)
Query: 2 PVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGE 61
P R + P + +L L +E + +TL K K G V+ G N
Sbjct: 1570 PTRQENWTPLKNDLENHLEDFELEV----ELLITLIKSEKGSLGFTVTKG-------NQR 1618
Query: 62 TSIVISDVLPG-GPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
+ DV+ +DG L+ DR++ VN T + ++ H+ AV LR + K +V+ R
Sbjct: 1619 IGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1676
Score = 37.7 bits (86), Expect = 0.066
Identities = 24/91 (26%), Positives = 48/91 (52%), Gaps = 9/91 (9%)
Query: 512 MVRFKKGDSVGL--RLAGGN-----DVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
+V KK GL ++ GG D+GIF++ + G A+ +G L+ GD+++ VN+
Sbjct: 902 LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 961
Query: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADV 594
G+ A+ L P+ ++ +++Q + +
Sbjct: 962 EGVSHHAAIEILQNAPE-DVTLVISQPKEKI 991
Score = 37.4 bits (85), Expect = 0.086
Identities = 63/325 (19%), Positives = 117/325 (36%), Gaps = 79/325 (24%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
S + VK++ A + G + GD+ILK+NG + +S + + + ++ L++ R
Sbjct: 1338 SIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRP 1397
Query: 385 SQQTLINIPS-------------------------LNDSDSEIEDISEIESNRSFSPEER 419
L I + + S S E+ +S + R
Sbjct: 1398 PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1457
Query: 420 RHQYSDYDYHSSSEKLKERPSS----------REDTPSRLSRMGATPTPFKSTGDIAGTV 469
R YSD S + L P++ + + +S+ + KS D T+
Sbjct: 1458 RDSYSDSS-GSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM 1516
Query: 470 VPETNK---EPRYQEDPPAP-QPKAAPRTFLRPSPEDEA-----------IYGPNTK--- 511
K +P +++ P+P P AP +P E + I P +
Sbjct: 1517 FYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENW 1576
Query: 512 -----------------------MVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQE 547
+++ +KG S+G + GN +G +V + + +
Sbjct: 1577 TPLKNDLENHLEDFELEVELLITLIKSEKG-SLGFTVTKGNQRIGCYVHDVIQDPAKSDG 1635
Query: 548 GLQEGDQILKVNTQDFRGLVREDAV 572
L+ GD+++KVN D + DAV
Sbjct: 1636 RLKPGDRLIKVNDTDVTNMTHTDAV 1660
Score = 36.6 bits (83), Expect = 0.15
Identities = 75/363 (20%), Positives = 133/363 (36%), Gaps = 84/363 (23%)
Query: 308 VLLMKSRANEEYGL-----------RLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGT 356
+ L+ + + +YGL RL IF+ + G A DG L GD ++ +N
Sbjct: 900 ITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 959
Query: 357 VTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPS-----LND-----------SDS 400
E +S A ++++ + + LV+ + ++ + +PS N+ DS
Sbjct: 960 SLEGVSHHAAIEILQNAPEDVTLVISQPKEK-ISKVPSTPVHLTNEMKNYMKKSSYMQDS 1018
Query: 401 EIEDISEIE----------SNRSFSPEE--RRHQYSDYDYHSSSEKLKER---------- 438
I+ S+ S SF P R S D + S L +
Sbjct: 1019 AIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHL 1078
Query: 439 -----PSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKA--- 490
S+ +PS AT + + + T P + Y + + +A
Sbjct: 1079 GDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYS 1138
Query: 491 APRTFLRPSPEDEAIYGPNTKM-----------------VRFKKGD-SVGLRLAGGNDV- 531
+ + P E + + KM V K D S+G+ + GG +
Sbjct: 1139 SSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTS 1198
Query: 532 ----GIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTI 586
GI+V + +AE +G + +GD++L VN G + AV L G++V +
Sbjct: 1199 VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHL 1256
Query: 587 LAQ 589
L +
Sbjct: 1257 LLE 1259
Score = 35.8 bits (81), Expect = 0.25
Identities = 18/46 (39%), Positives = 27/46 (58%)
Query: 338 ATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
A DG L GD ++K+N T NM+ TDA L+ + ++LV+ R
Sbjct: 1631 AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1676
Score = 35.0 bits (79), Expect = 0.42
Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQ 386
+++ ++ +A +GNL D+I +NG T+ M+L + + ++ S L +VL+ ++
Sbjct: 1717 VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS---LPSLVLKATR 1773
Query: 387 QTLINIPSLNDSDSEIEDISEIESNRSFS 415
L +PS S + + N S+S
Sbjct: 1774 NDLPVVPS--SKRSAVSAPKSTKGNGSYS 1800
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 75.1 bits (183), Expect = 4e-13
Identities = 87/383 (22%), Positives = 153/383 (39%), Gaps = 48/383 (12%)
Query: 34 VTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVMVNGT 91
V L+KD+K G G + GG + G I IS V PGGPAD G L+ DR++ VN
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLG---IFISSVAPGGPADLDGCLKPGDRLISVNSV 1150
Query: 92 PMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSF 151
+E V H A++ L+ + + +V+ +P K +++ + ++P + +E
Sbjct: 1151 SLEGVSHHAAIEILQNAPEDVTLVISQP-KEKISKVPSTP--------VHLTNEMKNYMK 1201
Query: 152 RSGYSERSRLNSHGGRSRSWEDSPER----------GRPHERARSRERDLSRDRSRGRSL 201
+S Y + S ++S + W R G E + S + + S +S
Sbjct: 1202 KSSYMQDSAIDS-SSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQ 1260
Query: 202 ERGLDQDHA--RTRDRSRGRS-----LERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYH 254
G H +T S+ S + + + + ++ + + G S DY
Sbjct: 1261 VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1320
Query: 255 RAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSR 314
D E YS S + ++ + + S SP +PG I + +
Sbjct: 1321 SDMD---EATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPP---KPGDIFEVELAKN 1374
Query: 315 ANE---------EYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTD 365
N +R G I+VK + G A DG +H+GD +L +NG E +
Sbjct: 1375 DNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQ 1433
Query: 366 ARKLIEKSRGKLQLVVLRDSQQT 388
A + + + + L++ + T
Sbjct: 1434 AVETLRNTGQVVHLLLEKGQSPT 1456
Score = 47.8 bits (112), Expect = 6e-05
Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 6/89 (6%)
Query: 32 YTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVN 89
+ V L K+ GI+V+GG + G I + V+P G A DG + + DRV+ VN
Sbjct: 1367 FEVELAKNDN-SLGISVTGGVNTSVRHGG---IYVKAVIPQGAAESDGRIHKGDRVLAVN 1422
Query: 90 GTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
G +E H AV+ LR +G+V +++++
Sbjct: 1423 GVSLEGATHKQAVETLRNTGQVVHLLLEK 1451
Score = 42.4 bits (98), Expect = 0.003
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 12/118 (10%)
Query: 2 PVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGE 61
P R + P + +L L +E + +TL K K G V+ G N
Sbjct: 1761 PTRQENWTPLKNDLENHLEDFELEV----ELLITLIKSEKGSLGFTVTKG-------NQR 1809
Query: 62 TSIVISDVLPG-GPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
+ DV+ +DG L+ DR++ VN T + ++ H+ AV LR + K +V+ R
Sbjct: 1810 IGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1867
Score = 39.7 bits (91), Expect = 0.017
Identities = 52/228 (22%), Positives = 92/228 (40%), Gaps = 54/228 (23%)
Query: 375 GKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEK 434
GK + R ++L + LN+S S ++ + SPE R+H
Sbjct: 1001 GKPSHQMSRSDAESLAGVTKLNNSKSV--------ASLNRSPERRKH------------- 1039
Query: 435 LKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRT 494
E SS + P + +G T S+G+ + V P R
Sbjct: 1040 --ESDSSSIEDPGQAYVLGMT---MHSSGNSSSQV-------------PLKENDVLHKRW 1081
Query: 495 FLRPSPEDEAIYGPNTKMVRFKKGDSVGL--RLAGGN-----DVGIFVAGIQEGTSAEQE 547
+ SPE E +V KK GL ++ GG D+GIF++ + G A+ +
Sbjct: 1082 SIVSSPEREIT------LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLD 1135
Query: 548 G-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADV 594
G L+ GD+++ VN+ G+ A+ L P+ ++ +++Q + +
Sbjct: 1136 GCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPE-DVTLVISQPKEKI 1182
Score = 37.4 bits (85), Expect = 0.086
Identities = 63/325 (19%), Positives = 117/325 (36%), Gaps = 79/325 (24%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
S + VK++ A + G + GD+ILK+NG + +S + + + ++ L++ R
Sbjct: 1529 SIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRP 1588
Query: 385 SQQTLINIPS-------------------------LNDSDSEIEDISEIESNRSFSPEER 419
L I + + S S E+ +S + R
Sbjct: 1589 PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1648
Query: 420 RHQYSDYDYHSSSEKLKERPSS----------REDTPSRLSRMGATPTPFKSTGDIAGTV 469
R YSD S + L P++ + + +S+ + KS D T+
Sbjct: 1649 RDSYSDSS-GSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM 1707
Query: 470 VPETNK---EPRYQEDPPAP-QPKAAPRTFLRPSPEDEA-----------IYGPNTK--- 511
K +P +++ P+P P AP +P E + I P +
Sbjct: 1708 FYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENW 1767
Query: 512 -----------------------MVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQE 547
+++ +KG S+G + GN +G +V + + +
Sbjct: 1768 TPLKNDLENHLEDFELEVELLITLIKSEKG-SLGFTVTKGNQRIGCYVHDVIQDPAKSDG 1826
Query: 548 GLQEGDQILKVNTQDFRGLVREDAV 572
L+ GD+++KVN D + DAV
Sbjct: 1827 RLKPGDRLIKVNDTDVTNMTHTDAV 1851
Score = 36.6 bits (83), Expect = 0.15
Identities = 75/363 (20%), Positives = 133/363 (36%), Gaps = 84/363 (23%)
Query: 308 VLLMKSRANEEYGL-----------RLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGT 356
+ L+ + + +YGL RL IF+ + G A DG L GD ++ +N
Sbjct: 1091 ITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 1150
Query: 357 VTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPS-----LND-----------SDS 400
E +S A ++++ + + LV+ + ++ + +PS N+ DS
Sbjct: 1151 SLEGVSHHAAIEILQNAPEDVTLVISQPKEK-ISKVPSTPVHLTNEMKNYMKKSSYMQDS 1209
Query: 401 EIEDISEIE----------SNRSFSPEE--RRHQYSDYDYHSSSEKLKER---------- 438
I+ S+ S SF P R S D + S L +
Sbjct: 1210 AIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHL 1269
Query: 439 -----PSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKA--- 490
S+ +PS AT + + + T P + Y + + +A
Sbjct: 1270 GDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYS 1329
Query: 491 APRTFLRPSPEDEAIYGPNTKM-----------------VRFKKGD-SVGLRLAGGNDV- 531
+ + P E + + KM V K D S+G+ + GG +
Sbjct: 1330 SSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTS 1389
Query: 532 ----GIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTI 586
GI+V + +AE +G + +GD++L VN G + AV L G++V +
Sbjct: 1390 VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHL 1447
Query: 587 LAQ 589
L +
Sbjct: 1448 LLE 1450
Score = 35.8 bits (81), Expect = 0.25
Identities = 18/46 (39%), Positives = 27/46 (58%)
Query: 338 ATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
A DG L GD ++K+N T NM+ TDA L+ + ++LV+ R
Sbjct: 1822 AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1867
Score = 35.0 bits (79), Expect = 0.42
Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQ 386
+++ ++ +A +GNL D+I +NG T+ M+L + + ++ S L +VL+ ++
Sbjct: 1908 VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS---LPSLVLKATR 1964
Query: 387 QTLINIPSLNDSDSEIEDISEIESNRSFS 415
L +PS S + + N S+S
Sbjct: 1965 NDLPVVPS--SKRSAVSAPKSTKGNGSYS 1991
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 75.1 bits (183), Expect = 4e-13
Identities = 87/383 (22%), Positives = 153/383 (39%), Gaps = 48/383 (12%)
Query: 34 VTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVMVNGT 91
V L+KD+K G G + GG + G I IS V PGGPAD G L+ DR++ VN
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLG---IFISSVAPGGPADLDGCLKPGDRLISVNSV 1131
Query: 92 PMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSF 151
+E V H A++ L+ + + +V+ +P K +++ + ++P + +E
Sbjct: 1132 SLEGVSHHAAIEILQNAPEDVTLVISQP-KEKISKVPSTP--------VHLTNEMKNYMK 1182
Query: 152 RSGYSERSRLNSHGGRSRSWEDSPER----------GRPHERARSRERDLSRDRSRGRSL 201
+S Y + S ++S + W R G E + S + + S +S
Sbjct: 1183 KSSYMQDSAIDS-SSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQ 1241
Query: 202 ERGLDQDHA--RTRDRSRGRS-----LERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYH 254
G H +T S+ S + + + + ++ + + G S DY
Sbjct: 1242 VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1301
Query: 255 RAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSR 314
D E YS S + ++ + + S SP +PG I + +
Sbjct: 1302 SDMD---EATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPP---KPGDIFEVELAKN 1355
Query: 315 ANE---------EYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTD 365
N +R G I+VK + G A DG +H+GD +L +NG E +
Sbjct: 1356 DNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQ 1414
Query: 366 ARKLIEKSRGKLQLVVLRDSQQT 388
A + + + + L++ + T
Sbjct: 1415 AVETLRNTGQVVHLLLEKGQSPT 1437
Score = 47.8 bits (112), Expect = 6e-05
Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 6/89 (6%)
Query: 32 YTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVN 89
+ V L K+ GI+V+GG + G I + V+P G A DG + + DRV+ VN
Sbjct: 1348 FEVELAKNDN-SLGISVTGGVNTSVRHGG---IYVKAVIPQGAAESDGRIHKGDRVLAVN 1403
Query: 90 GTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
G +E H AV+ LR +G+V +++++
Sbjct: 1404 GVSLEGATHKQAVETLRNTGQVVHLLLEK 1432
Score = 42.4 bits (98), Expect = 0.003
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 12/118 (10%)
Query: 2 PVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGE 61
P R + P + +L L +E + +TL K K G V+ G N
Sbjct: 1742 PTRQENWTPLKNDLENHLEDFELEV----ELLITLIKSEKGSLGFTVTKG-------NQR 1790
Query: 62 TSIVISDVLPG-GPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
+ DV+ +DG L+ DR++ VN T + ++ H+ AV LR + K +V+ R
Sbjct: 1791 IGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1848
Score = 38.1 bits (87), Expect = 0.050
Identities = 51/229 (22%), Positives = 90/229 (39%), Gaps = 40/229 (17%)
Query: 395 LNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGA 454
L +S E D + E P E Y D S K + E P ++ +
Sbjct: 946 LQNSSKEKNDKASWEEK----PREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVG 1001
Query: 455 TPTPFKSTGD---IAGTV-------VPETNKEP---RYQEDPPAPQPKAAP--------R 493
P+ S D +AG V N+ P +++ D + + R
Sbjct: 1002 KPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKR 1061
Query: 494 TFLRPSPEDEAIYGPNTKMVRFKKGDSVGL--RLAGGN-----DVGIFVAGIQEGTSAEQ 546
+ SPE E +V KK GL ++ GG D+GIF++ + G A+
Sbjct: 1062 WSIVSSPEREIT------LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADL 1115
Query: 547 EG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADV 594
+G L+ GD+++ VN+ G+ A+ L P+ ++ +++Q + +
Sbjct: 1116 DGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPE-DVTLVISQPKEKI 1163
Score = 37.4 bits (85), Expect = 0.086
Identities = 63/325 (19%), Positives = 117/325 (36%), Gaps = 79/325 (24%)
Query: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
S + VK++ A + G + GD+ILK+NG + +S + + + ++ L++ R
Sbjct: 1510 SIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRP 1569
Query: 385 SQQTLINIPS-------------------------LNDSDSEIEDISEIESNRSFSPEER 419
L I + + S S E+ +S + R
Sbjct: 1570 PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1629
Query: 420 RHQYSDYDYHSSSEKLKERPSS----------REDTPSRLSRMGATPTPFKSTGDIAGTV 469
R YSD S + L P++ + + +S+ + KS D T+
Sbjct: 1630 RDSYSDSS-GSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM 1688
Query: 470 VPETNK---EPRYQEDPPAP-QPKAAPRTFLRPSPEDEA-----------IYGPNTK--- 511
K +P +++ P+P P AP +P E + I P +
Sbjct: 1689 FYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENW 1748
Query: 512 -----------------------MVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQE 547
+++ +KG S+G + GN +G +V + + +
Sbjct: 1749 TPLKNDLENHLEDFELEVELLITLIKSEKG-SLGFTVTKGNQRIGCYVHDVIQDPAKSDG 1807
Query: 548 GLQEGDQILKVNTQDFRGLVREDAV 572
L+ GD+++KVN D + DAV
Sbjct: 1808 RLKPGDRLIKVNDTDVTNMTHTDAV 1832
Score = 36.6 bits (83), Expect = 0.15
Identities = 75/363 (20%), Positives = 133/363 (36%), Gaps = 84/363 (23%)
Query: 308 VLLMKSRANEEYGL-----------RLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGT 356
+ L+ + + +YGL RL IF+ + G A DG L GD ++ +N
Sbjct: 1072 ITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 1131
Query: 357 VTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPS-----LND-----------SDS 400
E +S A ++++ + + LV+ + ++ + +PS N+ DS
Sbjct: 1132 SLEGVSHHAAIEILQNAPEDVTLVISQPKEK-ISKVPSTPVHLTNEMKNYMKKSSYMQDS 1190
Query: 401 EIEDISEIE----------SNRSFSPEE--RRHQYSDYDYHSSSEKLKER---------- 438
I+ S+ S SF P R S D + S L +
Sbjct: 1191 AIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHL 1250
Query: 439 -----PSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKA--- 490
S+ +PS AT + + + T P + Y + + +A
Sbjct: 1251 GDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYS 1310
Query: 491 APRTFLRPSPEDEAIYGPNTKM-----------------VRFKKGD-SVGLRLAGGNDV- 531
+ + P E + + KM V K D S+G+ + GG +
Sbjct: 1311 SSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTS 1370
Query: 532 ----GIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTI 586
GI+V + +AE +G + +GD++L VN G + AV L G++V +
Sbjct: 1371 VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHL 1428
Query: 587 LAQ 589
L +
Sbjct: 1429 LLE 1431
Score = 35.8 bits (81), Expect = 0.25
Identities = 18/46 (39%), Positives = 27/46 (58%)
Query: 338 ATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
A DG L GD ++K+N T NM+ TDA L+ + ++LV+ R
Sbjct: 1803 AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1848
Score = 35.0 bits (79), Expect = 0.42
Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQ 386
+++ ++ +A +GNL D+I +NG T+ M+L + + ++ S L +VL+ ++
Sbjct: 1889 VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS---LPSLVLKATR 1945
Query: 387 QTLINIPSLNDSDSEIEDISEIESNRSFS 415
L +PS S + + N S+S
Sbjct: 1946 NDLPVVPS--SKRSAVSAPKSTKGNGSYS 1972
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 73.9 bits (180), Expect = 8e-13
Identities = 68/210 (32%), Positives = 98/210 (46%), Gaps = 34/210 (16%)
Query: 118 RPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYS-----ERSRLNSH---GGRSR 169
RPRK++ + + +D+ ++ RS R S RSR SH G S
Sbjct: 236 RPRKIKKDGKEGAEEIDRH------VERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
Query: 170 SWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDF 229
S++ ER + +R ++ ++R R RS++RGL++ +R+R+R R RS R
Sbjct: 290 SFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRK--- 346
Query: 230 GPSRDRDRDR----SRGRSIDQDY--ERAYHRAYDPDYERAYSPEYR-RGA--------- 273
G RDRDR+R RGR D+DY ER R + + R S E R RG
Sbjct: 347 GDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKED 406
Query: 274 RHDARSR-GPRSRSREHPHSRSPSPEPRGR 302
+ D R R R +E HSRS S E + R
Sbjct: 407 KDDRRHRDDKRDSKKEKKHSRSRSRERKHR 436
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/179 (30%), Positives = 77/179 (43%), Gaps = 29/179 (16%)
Query: 157 ERSRLNSHGG---RSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTR 213
ER RL + R S +RG R+RSRER SR RSR R +R D+D R +
Sbjct: 300 ERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRR-DRDREREK 358
Query: 214 DRSRGRSLERGLDHDFG----PSRDRDRDRSRGRSIDQDYERAYHRAYDPD--------- 260
+ RGR +R D + G R+R R+RS+ + + E H+ D
Sbjct: 359 ENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRD 418
Query: 261 ------YERAYSPEYRRGARHDARSRGPRSRSR------EHPHSRSPSPEPRGRPGPIG 307
+ R+ S E + +R +R+ G RSRSR +H + R R G G
Sbjct: 419 SKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQG 477
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/131 (28%), Positives = 63/131 (48%), Gaps = 7/131 (5%)
Query: 135 QDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHE---RARSRERDL 191
+DD+ ++ RS RSR S RS S E+ H+ + +S +R
Sbjct: 413 RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSR 472
Query: 192 SRDRSRGRSLERGLDQDHARTRDRSR--GRSLERGLDHDFGPSRDRD--RDRSRGRSIDQ 247
S + R S+E+ ++H+ ++++SR RS ER D S+D+ DR R +SI+Q
Sbjct: 473 SGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQ 532
Query: 248 DYERAYHRAYD 258
+ + H+ D
Sbjct: 533 ESQEKQHKNKD 543
Score = 46.2 bits (108), Expect = 2e-04
Identities = 39/157 (24%), Positives = 72/157 (45%), Gaps = 21/157 (13%)
Query: 134 DQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSR 193
D+DDR D+ D + + RSR H RSRS A R R S+
Sbjct: 406 DKDDRRHRD-DKRDSKKEKKHSRSRSRERKHRSRSRS-----------RNAGKRSRSRSK 453
Query: 194 DRSRGRSLERGLDQDHARTRDRSRGR--SLERGLDHDFGPSRDRDRDRSRGRSIDQDYER 251
++S E ++ + R+R S+GR S+E+ + PS+++ R RSR + ER
Sbjct: 454 EKSSKHKNE-SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSK------ER 506
Query: 252 AYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSRE 288
++ R + +++ + RR + S+ + ++++
Sbjct: 507 SHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
Score = 30.8 bits (68), Expect = 8.0
Identities = 21/78 (26%), Positives = 37/78 (47%), Gaps = 17/78 (21%)
Query: 156 SERSRLNSHGG-----RSRSWEDSPERGRPHERARSRERDLSRDRS------------RG 198
++RSR S G +S+ E SP + + +R+RS+ER RD S R
Sbjct: 468 NKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRS 527
Query: 199 RSLERGLDQDHARTRDRS 216
+S+E+ + + +D +
Sbjct: 528 QSIEQESQEKQHKNKDET 545
>gi|13129124 caspase recruitment domain protein 14 isoform 1 [Homo
sapiens]
Length = 1004
Score = 73.2 bits (178), Expect = 1e-12
Identities = 104/422 (24%), Positives = 168/422 (39%), Gaps = 60/422 (14%)
Query: 523 LRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGL---VREDAVLY----L 575
+ + GGN GIF+ + G++A+Q L+ G QI+ V+ + L V ED L L
Sbjct: 583 ISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGL 642
Query: 576 LEIPKGEMVTILAQSRADVYRDIL------ACGRGDSFFIRSHFECEKETPQSLAFTRGE 629
L G + + D Y+ +L GDSF+IR + E L E
Sbjct: 643 LRRVDG-FCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNE 701
Query: 630 VFRVVDTLYDGKLGNWLAVRIGNELEK-----GLIPNKSRAEQ--MASVQN-------AQ 675
V V DT++ G G W A R+ + K G IPN SRA+Q +A +Q+ +
Sbjct: 702 VLHVTDTMFQG-CGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTR 760
Query: 676 RDNAGDRADFWRM----RGQRSGVKKNLRKSREDLTAVVSVSTKFPA--------YERVL 723
+ ++G R+ + + S ++ + + + D + + ST F A Y V
Sbjct: 761 KPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLVW 820
Query: 724 LREAGFKRPVVLF-GPIADIAMEKLA---------------NELPDWFQTAKTEPKDAGS 767
RPV+L + I EKL E W Q + S
Sbjct: 821 PHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVS 880
Query: 768 EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMR-- 825
V R + V ++E++ HALLDV +V L+ FPIVI + + + K +
Sbjct: 881 GGRCWVTR-HAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGL 939
Query: 826 QRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
QRL + + + L + + + S D ++ I +Q + VW
Sbjct: 940 QRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWT 999
Query: 886 SE 887
+
Sbjct: 1000 EQ 1001
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 70.9 bits (172), Expect = 7e-12
Identities = 43/131 (32%), Positives = 63/131 (48%), Gaps = 7/131 (5%)
Query: 172 EDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGP 231
E + ER R ER R RER+ R+R R R ER L+++ AR R+R R + +R D D
Sbjct: 674 ERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDH 733
Query: 232 SRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPH 291
R+R+R+R R R +++ ER + ER E R + R R +E
Sbjct: 734 DRERERERERDREKERERER-------EERERERERERERERERERERERARERDKERER 786
Query: 292 SRSPSPEPRGR 302
R + +GR
Sbjct: 787 QRDWEDKDKGR 797
Score = 69.3 bits (168), Expect = 2e-11
Identities = 56/176 (31%), Positives = 74/176 (42%), Gaps = 28/176 (15%)
Query: 144 DEFDGRSFRSGYSERSRLNS------------HGGRSRSWEDSPER---------GRPHE 182
D+ SF + ER R ++ H GR+ E R R E
Sbjct: 615 DQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDE 674
Query: 183 RARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSRG 242
RAR R+R+ RDR R R ER D++ + R+ R R+ ER + R+++RDR R
Sbjct: 675 RARERDRERERDRERERERERERDREREKERELERERARERERE------REKERDRERD 728
Query: 243 RSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPE 298
R D D ER R D + ER E R R R R R R RE +R E
Sbjct: 729 RDRDHDRERERERERDREKEREREREERERERERERER-ERERERERERARERDKE 783
Score = 59.7 bits (143), Expect = 2e-08
Identities = 53/169 (31%), Positives = 72/169 (42%), Gaps = 15/169 (8%)
Query: 147 DGRSFRSGYSERSRLNSHGGRSRSWEDSPERGR-PHERARSRERDL---SRDRSRGRS-- 200
D RS Y ER R R ++ + S ER +R +RERD S R +GR+
Sbjct: 594 DSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDE 653
Query: 201 -------LERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAY 253
ER +D+ R +R+R R ER D + R+R+RDR R + + + ERA
Sbjct: 654 LERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAR 713
Query: 254 HRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGR 302
R + + ER E R HD R R RE R R R
Sbjct: 714 EREREREKER--DRERDRDRDHDRERERERERDREKEREREREERERER 760
Score = 57.4 bits (137), Expect = 8e-08
Identities = 56/194 (28%), Positives = 85/194 (43%), Gaps = 18/194 (9%)
Query: 96 VLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGY 155
VLHS + R K ++ + RK ++ L+ P + + D S RS
Sbjct: 1227 VLHSGS----RDREKTKSLEITGERKSRIDQLKRGEP--SRSTSSDRQDSRSHSSRRSSP 1280
Query: 156 SERSRLNSHGGRSRSWEDSPERGR-PHERARSRERDLSRDRSRGRSLERGLDQDHARTRD 214
+++S G S + ER R H+R R RER RD +R R +R D+D R RD
Sbjct: 1281 ESDRQVHSRSGSFDSRDRLQERDRYEHDRERERER---RD-TRQREWDRDADKDWPRNRD 1336
Query: 215 RSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGAR 274
R R R ER + D DR+R+R S+++D +R R ++ S + R
Sbjct: 1337 RDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFE-------SSQIESVKR 1389
Query: 275 HDARSRGPRSRSRE 288
+A+ G R E
Sbjct: 1390 CEAKLEGEHERDLE 1403
Score = 53.9 bits (128), Expect = 9e-07
Identities = 55/194 (28%), Positives = 73/194 (37%), Gaps = 51/194 (26%)
Query: 156 SERSRLNSHGGRSR---SWE---DSPERGR--------------------PHERARSRER 189
S S+++SH S SWE PER R +R +RER
Sbjct: 578 SRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRER 637
Query: 190 D---------------LSRDRSR---------GRSLERGLDQDHARTRDRSRGRSLERGL 225
D L RD R R ER ++D R RDR R R ER
Sbjct: 638 DQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERER 697
Query: 226 DHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHD-ARSRGPRS 284
D + R+ +R+R+R R +++ ER R D D++R E R + R R R
Sbjct: 698 DREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERE 757
Query: 285 RSREHPHSRSPSPE 298
R RE R E
Sbjct: 758 RERERERERERERE 771
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/137 (31%), Positives = 55/137 (40%), Gaps = 15/137 (10%)
Query: 157 ERSRLNSHGGRSRSWEDSPERGRPHERARS-RERDLSRDRSRGRSLERGLDQDHARTRDR 215
ER R H R R E +R + ER R RER+ R+R R R ER ++ R ++R
Sbjct: 726 ERDRDRDHD-RERERERERDREKEREREREERERERERERERERERERERERARERDKER 784
Query: 216 SRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARH 275
R R E D D G RD R + I +D D ER YR
Sbjct: 785 ERQRDWE---DKDKG----RDDRREKREEIRED-----RNPRDGHDERKSKKRYRNEGSP 832
Query: 276 DARSRGPRSRSREHPHS 292
R + P+ R P S
Sbjct: 833 SPR-QSPKRRREHSPDS 848
Score = 42.7 bits (99), Expect = 0.002
Identities = 61/220 (27%), Positives = 83/220 (37%), Gaps = 24/220 (10%)
Query: 93 MEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRS-- 150
+ED H + Q R S ++ R + + SP +D A D+ GR
Sbjct: 1175 IEDAQHRKPMDQKRSS----SLGSNRSNRSHTSGRLRSP---SNDSAHRSGDDQSGRKRV 1227
Query: 151 FRSGYSERSRLNSHG--GRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQD 208
SG +R + S G +S D +RG P R+ S +R SR S RS Q
Sbjct: 1228 LHSGSRDREKTKSLEITGERKSRIDQLKRGEP-SRSTSSDRQDSRSHSSRRSSPESDRQV 1286
Query: 209 HARTRD-RSRGRSLERG-LDHDFGPSR----------DRDRDRSRGRSIDQDYERAYHRA 256
H+R+ SR R ER +HD R DRD D+ R+ D+D R R
Sbjct: 1287 HSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERE 1346
Query: 257 YDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPS 296
+ D R E R R R R S+ S
Sbjct: 1347 RERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIES 1386
Score = 42.0 bits (97), Expect = 0.003
Identities = 46/154 (29%), Positives = 63/154 (40%), Gaps = 10/154 (6%)
Query: 152 RSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRG-RSLERGLDQDHA 210
R ER R R R E ER R ER R+RERD R+R R ++G D
Sbjct: 743 RDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE 802
Query: 211 RTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYR 270
+ + R+ G HD S+ R R+ S Q +R R + PD + AY+
Sbjct: 803 KREEIREDRNPRDG--HDERKSKKRYRNEG-SPSPRQSPKR--RREHSPDSD-AYNSGDD 856
Query: 271 RGARHDARSRGPRSRSREHPHSRSPSPEPRGRPG 304
+ +H S+ R + S SPS R G
Sbjct: 857 KNEKHRLLSQVVRP---QESRSLSPSHLTEDRQG 887
Score = 38.5 bits (88), Expect = 0.038
Identities = 62/272 (22%), Positives = 99/272 (36%), Gaps = 24/272 (8%)
Query: 182 ERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSR 241
+R +S R S R +GR Q H R +R +R + D R+ ++D+S
Sbjct: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSS 442
Query: 242 GRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRG 301
R D E R D A RR R D+R R++ S +PR
Sbjct: 443 SRDHRDDREPRDGR----DRRDARDTRDRRELR-DSRDMRDSREMRDYSRDTKESRDPRD 497
Query: 302 RPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENM 361
+R +Y R G KE T + G H + + + T N
Sbjct: 498 S--------RSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE---ESSRTEIRNE 546
Query: 362 SLTDARKLIE-----KSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSP 416
S ++R I +SRG++ + + S+ + + + S+S D E RS P
Sbjct: 547 SRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWE---TRSSYP 603
Query: 417 EERRHQYSDYDYHSSSEKLKERPSSREDTPSR 448
E R+ D + + R R+ +R
Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNR 635
Score = 38.1 bits (87), Expect = 0.050
Identities = 40/132 (30%), Positives = 50/132 (37%), Gaps = 5/132 (3%)
Query: 163 SHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLE 222
SH S + SP R R R + R +S R ER +D RDR + E
Sbjct: 376 SHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHER--REDTRGKRDREKDSREE 433
Query: 223 RGLDHDFGPSRDR--DRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSR 280
R + D SRD DR+ GR + R + S E R +R SR
Sbjct: 434 REYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESR 493
Query: 281 GPR-SRSREHPH 291
PR SRS H
Sbjct: 494 DPRDSRSTRDAH 505
Score = 35.8 bits (81), Expect = 0.25
Identities = 43/177 (24%), Positives = 63/177 (35%), Gaps = 18/177 (10%)
Query: 160 RLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLD-QDHARTRDRSRG 218
R ++ G R R + ER +++ SR+ R+ GR D +D RD
Sbjct: 417 REDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDM 476
Query: 219 RSLERGLDHDFGPSRDRDRDRSRGRSIDQDYE----RAYHRAYD--PDYERAYS------ 266
R D+ RD SR DY R HR D P+ R+Y
Sbjct: 477 RDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE 536
Query: 267 ----PEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEY 319
E R +R+++RS R+ R P +G G G + +N Y
Sbjct: 537 ESSRTEIRNESRNESRSE-IRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNY 592
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 68.9 bits (167), Expect = 3e-11
Identities = 82/336 (24%), Positives = 136/336 (40%), Gaps = 61/336 (18%)
Query: 11 PRRELSGWLRAPGMEELIWEQ--YTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISD 68
P++E +AP + EQ YTV L++ +K GFG ++ GGR+ + +
Sbjct: 1102 PKQESQFEFKAPQATQ---EQDFYTVELERGAK-GFGFSLRGGREY------NMDLYVLR 1151
Query: 69 VLPGGPAD--GLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR-------- 118
+ GPA+ G ++ D ++ +NG +++ HS A++ ++ G+ + +KR
Sbjct: 1152 LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1211
Query: 119 ----------------------PRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYS 156
P + Q +L++S P D + R +
Sbjct: 1212 DPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSRE 1271
Query: 157 ERSRLNSH---GGRSRSWEDSPERG--RPHERARSRERDLSRDRSRGRSLERGLDQDHAR 211
+ N H G SR P+ G RP +RA RD +R+ + + + R
Sbjct: 1272 YSRQPNEHHTWNGTSR----KPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRR 1327
Query: 212 TRDRSRGRSLERGLDH----DFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSP 267
RS +LER H D P R R+R +R R R R+ + E+ SP
Sbjct: 1328 EGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRR---RSLERLLEQRRSP 1384
Query: 268 EYRRGARHDARSRG-PRSRSREHPHSRSPSPEPRGR 302
E RRG + R++ R R+R R S + R R
Sbjct: 1385 ERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNR 1420
Score = 42.4 bits (98), Expect = 0.003
Identities = 40/139 (28%), Positives = 63/139 (45%), Gaps = 10/139 (7%)
Query: 314 RANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKS 373
R EY + L +V + G A + G + GD IL+ING T+NM + A +LI+
Sbjct: 1138 RGGREYNMDL----YVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNG 1193
Query: 374 RGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQ--YSDY--DYH 429
+++L + R PS +D + R+ P+ R+H S Y D H
Sbjct: 1194 GRRVRLFLKRGDGSVPEYDPS-SDRHGPATGPQGVPEVRA-GPDRRQHPSLESSYPPDLH 1251
Query: 430 SSSEKLKERPSSREDTPSR 448
SS ++R +R+ SR
Sbjct: 1252 KSSPHGEKRAHARDPKGSR 1270
Score = 41.2 bits (95), Expect = 0.006
Identities = 29/85 (34%), Positives = 43/85 (50%), Gaps = 8/85 (9%)
Query: 43 GFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVMVNGTPMEDVLHSF 100
GFG + GG E GE I I ++P G AD G L+ D ++ V+GTP+ H
Sbjct: 822 GFGFRILGGN-----EPGEP-IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 875
Query: 101 AVQQLRKSGKVAAIVVKRPRKVQVA 125
VQ ++++ K + + RKV A
Sbjct: 876 VVQLMQQAAKQGHVNLTVRRKVVFA 900
Score = 40.8 bits (94), Expect = 0.008
Identities = 62/328 (18%), Positives = 114/328 (34%), Gaps = 50/328 (15%)
Query: 16 SGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPH----FENGETSIV--ISDV 69
SG G+ + + Y V +++ GFG + P F N ++ I +
Sbjct: 953 SGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRI 1012
Query: 70 LPGGPAD--GLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVA------------AIV 115
+ G PAD G L+ DR++ VNG + + HS V ++++G A +
Sbjct: 1013 IEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATL 1072
Query: 116 VKRPRKVQVAALQASP-------------PLDQDDRAFEVMDEFDGRSFRSGYSERSR-- 160
+ K+ +P P + F+ + F + ER
Sbjct: 1073 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG 1132
Query: 161 --LNSHGGRS--------RSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHA 210
+ GGR R ED P R +++ + ++ R ++
Sbjct: 1133 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIEL--I 1190
Query: 211 RTRDRSRGRSLERGLDH--DFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPE 268
+ R L+RG ++ PS DR + + + + R P E +Y P+
Sbjct: 1191 KNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGV-PEVRAGPDRRQHPSLESSYPPD 1249
Query: 269 YRRGARHDARSRGPRSRSREHPHSRSPS 296
+ + H + R +SR P+
Sbjct: 1250 LHKSSPHGEKRAHARDPKGSREYSRQPN 1277
Score = 39.7 bits (91), Expect = 0.017
Identities = 19/42 (45%), Positives = 27/42 (64%)
Query: 548 GLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQ 589
GL+EGD I++VN ++ + L V L+E PKG VT+L Q
Sbjct: 679 GLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Score = 32.3 bits (72), Expect = 2.8
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 8/71 (11%)
Query: 35 TLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTP 92
T + S RGFG V GG + F + I ++ GPA DG ++ D +V VN T
Sbjct: 473 TKLRKSSRGFGFTVVGGDEPDEF------LQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
Query: 93 MEDVLHSFAVQ 103
+ H+ V+
Sbjct: 527 VLGHTHAQVVK 537
Score = 30.8 bits (68), Expect = 8.0
Identities = 35/171 (20%), Positives = 65/171 (38%), Gaps = 6/171 (3%)
Query: 419 RRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPR 478
R+ QY + + +K E+ ++ + + + T D + V P P
Sbjct: 383 RKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPP 442
Query: 479 YQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFV--- 535
+P P F R E + + +TK+ + +G G + GG++ F+
Sbjct: 443 SNPEPAREVPLQGKPFFTRNPSELKGKF-IHTKLRKSSRG--FGFTVVGGDEPDEFLQIK 499
Query: 536 AGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTI 586
+ + +G +A ++ GD I+ VN G V IP G V +
Sbjct: 500 SLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDL 550
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 68.2 bits (165), Expect = 5e-11
Identities = 47/153 (30%), Positives = 65/153 (42%), Gaps = 2/153 (1%)
Query: 135 QDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRD 194
+ DR E E D + R +ER N H R R E + R ER R +ERD R
Sbjct: 10 ETDRGKETERERDRQRERENQTERE--NRHRQRDRHRERDRQTDREKERERQKERDRQRQ 67
Query: 195 RSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYH 254
R R E ++ R R+R R ER D D R+ DR+R R R ++ ++
Sbjct: 68 RERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTE 127
Query: 255 RAYDPDYERAYSPEYRRGARHDARSRGPRSRSR 287
R D + ER E R + + + R R R
Sbjct: 128 RERDRERERQRQRERERQRQRERKRETDRERQR 160
Score = 62.8 bits (151), Expect = 2e-09
Identities = 48/156 (30%), Positives = 68/156 (43%), Gaps = 11/156 (7%)
Query: 135 QDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRD 194
Q DR E + D R ER R R R E ER R +R R R+R R+
Sbjct: 39 QRDRHRERDRQTDREKERERQKERDRQRQ---RERETERETERQRERQRQRERKRQTDRE 95
Query: 195 RSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYH 254
R + R ER + D R R+R GR + D R+RDR+R R R +++ +R
Sbjct: 96 RDKDRDRERKRETDRNRERNRKGGR------ERDKQTERERDRERERQRQRERERQRQRE 149
Query: 255 RAYDPDYERA--YSPEYRRGARHDARSRGPRSRSRE 288
R + D ER E R+ R R + + + +E
Sbjct: 150 RKRETDRERQRWAEREERKKERKKERKKERKEKKKE 185
Score = 56.2 bits (134), Expect = 2e-07
Identities = 36/138 (26%), Positives = 59/138 (42%), Gaps = 11/138 (7%)
Query: 167 RSRSWEDSPERGRPHERARSRERD-----------LSRDRSRGRSLERGLDQDHARTRDR 215
R R + +RG+ ER R R+R+ RDR R R + +++ R ++R
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62
Query: 216 SRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARH 275
R R ER + + R+R R R R R D++ ++ R + +R + G
Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRER 122
Query: 276 DARSRGPRSRSREHPHSR 293
D ++ R R RE R
Sbjct: 123 DKQTERERDRERERQRQR 140
Score = 31.6 bits (70), Expect = 4.7
Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 5/85 (5%)
Query: 167 RSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLD 226
R+R R R + R R+R+ R+R R R ER ++ R DR R R ER
Sbjct: 110 RNRERNRKGGRERDKQTERERDRE--RERQRQRERERQRQRERKRETDRERQRWAER--- 164
Query: 227 HDFGPSRDRDRDRSRGRSIDQDYER 251
+ R ++R + R ++ R
Sbjct: 165 EERKKERKKERKKERKEKKKEEKRR 189
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,204,587
Number of Sequences: 37866
Number of extensions: 2755079
Number of successful extensions: 18661
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 237
Number of HSP's successfully gapped in prelim test: 480
Number of HSP's that attempted gapping in prelim test: 12289
Number of HSP's gapped (non-prelim): 3692
length of query: 1190
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1076
effective length of database: 13,930,794
effective search space: 14989534344
effective search space used: 14989534344
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.