Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 116875767
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
(1748 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 3545 0.0
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 3170 0.0
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 762 0.0
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 747 0.0
gi|10092691 tight junction protein 3 [Homo sapiens] 659 0.0
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 150 1e-35
gi|95089461 discs large homolog 5 [Homo sapiens] 150 1e-35
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 141 5e-33
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 140 1e-32
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 138 4e-32
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 138 4e-32
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 138 5e-32
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 138 5e-32
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 133 2e-30
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 128 4e-29
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 98 6e-20
gi|169160873 PREDICTED: similar to hCG2040319 [Homo sapiens] 87 2e-16
gi|239747400 PREDICTED: similar to hCG2040319 [Homo sapiens] 87 2e-16
gi|239741226 PREDICTED: similar to hCG2040319 [Homo sapiens] 87 2e-16
gi|112382257 InaD-like [Homo sapiens] 84 2e-15
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 82 5e-15
gi|16933525 unc5C [Homo sapiens] 79 5e-14
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 79 5e-14
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 79 5e-14
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 79 5e-14
gi|45827729 scribble isoform b [Homo sapiens] 77 1e-13
gi|45827731 scribble isoform a [Homo sapiens] 77 1e-13
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 75 7e-13
gi|32261318 unc-5 homolog B [Homo sapiens] 72 6e-12
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 71 1e-11
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 3545 bits (9193), Expect = 0.0
Identities = 1748/1748 (100%), Positives = 1748/1748 (100%)
Query: 1 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL 60
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
Sbjct: 1 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL 60
Query: 61 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD 120
KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
Sbjct: 61 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD 120
Query: 121 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ 180
PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
Sbjct: 121 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ 180
Query: 181 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM 240
PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
Sbjct: 181 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM 240
Query: 241 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS 300
SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
Sbjct: 241 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS 300
Query: 301 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD 360
GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
Sbjct: 301 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD 360
Query: 361 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP 420
DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
Sbjct: 361 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP 420
Query: 421 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR 480
SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
Sbjct: 421 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR 480
Query: 481 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG 540
EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
Sbjct: 481 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG 540
Query: 541 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD 600
EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
Sbjct: 541 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD 600
Query: 601 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK 660
FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
Sbjct: 601 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK 660
Query: 661 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ 720
LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
Sbjct: 661 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ 720
Query: 721 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND 780
WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
Sbjct: 721 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND 780
Query: 781 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT 840
GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
Sbjct: 781 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT 840
Query: 841 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP 900
SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
Sbjct: 841 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP 900
Query: 901 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT 960
QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
Sbjct: 901 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT 960
Query: 961 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK 1020
PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
Sbjct: 961 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK 1020
Query: 1021 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY 1080
QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
Sbjct: 1021 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY 1080
Query: 1081 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY 1140
EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
Sbjct: 1081 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY 1140
Query: 1141 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE 1200
DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
Sbjct: 1141 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE 1200
Query: 1201 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK 1260
QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
Sbjct: 1201 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK 1260
Query: 1261 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD 1320
PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
Sbjct: 1261 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD 1320
Query: 1321 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL 1380
KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
Sbjct: 1321 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL 1380
Query: 1381 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ 1440
SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
Sbjct: 1381 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ 1440
Query: 1441 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP 1500
PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
Sbjct: 1441 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP 1500
Query: 1501 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK 1560
QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
Sbjct: 1501 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK 1560
Query: 1561 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA 1620
PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
Sbjct: 1561 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA 1620
Query: 1621 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS 1680
VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
Sbjct: 1621 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS 1680
Query: 1681 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC 1740
ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC
Sbjct: 1681 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC 1740
Query: 1741 VSVLIDHF 1748
VSVLIDHF
Sbjct: 1741 VSVLIDHF 1748
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 3170 bits (8218), Expect = 0.0
Identities = 1600/1748 (91%), Positives = 1615/1748 (92%), Gaps = 80/1748 (4%)
Query: 1 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL 60
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
Sbjct: 1 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL 60
Query: 61 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD 120
KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
Sbjct: 61 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD 120
Query: 121 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ 180
PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
Sbjct: 121 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ 180
Query: 181 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM 240
PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
Sbjct: 181 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM 240
Query: 241 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS 300
SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
Sbjct: 241 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS 300
Query: 301 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD 360
GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
Sbjct: 301 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD 360
Query: 361 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP 420
DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
Sbjct: 361 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP 420
Query: 421 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR 480
SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
Sbjct: 421 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR 480
Query: 481 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG 540
EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
Sbjct: 481 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG 540
Query: 541 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD 600
EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
Sbjct: 541 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD 600
Query: 601 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK 660
FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
Sbjct: 601 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK 660
Query: 661 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ 720
LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
Sbjct: 661 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ 720
Query: 721 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND 780
WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
Sbjct: 721 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND 780
Query: 781 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT 840
GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
Sbjct: 781 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT 840
Query: 841 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP 900
SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
Sbjct: 841 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP 900
Query: 901 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT 960
QAQPQPIHRIDSPGFKPASQQ P P N AV+H + P
Sbjct: 901 QAQPQPIHRIDSPGFKPASQQ-VYRKDPYPEEMMRQNHVLKQPAVSHPGH-------RPD 952
Query: 961 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK 1020
P+ +Y PQ + ++ RD E PT Y Y ++ R
Sbjct: 953 KEPNLTYEPQLPYVEKQAS-------RDLE-------QPTYRYESSSYTDQFSR------ 992
Query: 1021 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY 1080
+ E L YE ++P E+Q S Y
Sbjct: 993 -----------NYEHRLRYEDRVPMYEEQWS---------------------------YY 1014
Query: 1081 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY 1140
+D+ P YPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
Sbjct: 1015 DDKQP--------------YPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY 1060
Query: 1141 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE 1200
DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
Sbjct: 1061 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE 1120
Query: 1201 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK 1260
QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
Sbjct: 1121 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK 1180
Query: 1261 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD 1320
PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
Sbjct: 1181 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD 1240
Query: 1321 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL 1380
KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
Sbjct: 1241 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL 1300
Query: 1381 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ 1440
SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
Sbjct: 1301 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ 1360
Query: 1441 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP 1500
PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
Sbjct: 1361 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP 1420
Query: 1501 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK 1560
QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
Sbjct: 1421 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK 1480
Query: 1561 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA 1620
PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
Sbjct: 1481 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA 1540
Query: 1621 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS 1680
VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
Sbjct: 1541 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS 1600
Query: 1681 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC 1740
ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC
Sbjct: 1601 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC 1660
Query: 1741 VSVLIDHF 1748
VSVLIDHF
Sbjct: 1661 VSVLIDHF 1668
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 762 bits (1967), Expect = 0.0
Identities = 465/1002 (46%), Positives = 607/1002 (60%), Gaps = 129/1002 (12%)
Query: 134 EEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSR 193
E + P R + RS PR RS S SP + R +P P V L+KSR
Sbjct: 262 ERAYSPEYRRGARHDARSRG--PRSRSREHPHSRSPSPEPRG----RPG-PIGVLLMKSR 314
Query: 194 KNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSK 253
NEEYGLRL S IFVKE+++ LA +DGN+ EGD++LKINGTVTENMSLTDA+ LIE+S+
Sbjct: 315 ANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSR 374
Query: 254 GKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRS 313
GKL++VV RD + TL+N+P L+DS SE +DISEI+S +RS
Sbjct: 375 GKLQLVVLRDSQQTLINIPSLNDS-----DSEIEDISEIES----------------NRS 413
Query: 314 RSPDQRSEP-SDHSRHSPQQPSNGSLRSRDE--ERISKPGAVSTPVKHADDHTPKTVEEV 370
SP++R SD+ HS + SR++ R+S+ GA TP K D V E
Sbjct: 414 FSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPET 473
Query: 371 TVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKG 430
E ++ P P+PK P L SP D + I P+ K+V+F+KG
Sbjct: 474 NKEPRYQEDPPAPQPKAA------PRTFLRPSPED---------EAIYGPNTKMVRFKKG 518
Query: 431 DSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDL 490
DSVGLRLAGGNDVGIFVAG+ E + A +EGL+EGDQIL+VN DF ++RE+AVL+LL++
Sbjct: 519 DSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEI 578
Query: 491 PKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLY 550
PKGE VTILAQ + DVYR I+ GDSF+IR+HFE EKE+P L+F +GEVFRVVDTLY
Sbjct: 579 PKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLY 638
Query: 551 NGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSS 610
+GKLG+WLA+RIG E+E+G+IPNK+RAEQ+ASVQ + GDRADFWR RG RS
Sbjct: 639 DGKLGNWLAVRIG---NELEKGLIPNKSRAEQMASVQ-NAQRDNAGDRADFWRMRGQRSG 694
Query: 611 -KRNLRKSREDLSA-QPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDI 668
K+NLRKSREDL+A V TKFPAYERV+LREAGF RPV +FGPIAD+A EKLA E PD
Sbjct: 695 VKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDW 754
Query: 669 YQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFL 728
+Q AK+EP+DAG+ ++S+G++RL+T++QII+QDKHALLDVTP AVD LNY QW+PIV+F
Sbjct: 755 FQTAKTEPKDAGS-EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFF 813
Query: 729 NPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKE 788
NPDS+QGVKTMR RL P S KS+RKL+++++KL+K HLFT TINLNS ND W+G+LK+
Sbjct: 814 NPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKD 873
Query: 789 AIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDT 848
IQ QQ + VWVSEGK +G D +DR+SYL+A G++Y S DSR SD+EDTD
Sbjct: 874 TIQHQQGEAVWVSEGKMEGMDDDP----EDRMSYLTAMGADY--LSCDSRLISDFEDTDG 927
Query: 849 EGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIH 908
EGGAYTD ELDE + P S+ITRSSEPV+ H E+ P P+AQ +
Sbjct: 928 EGGAYTDNELDEPAEE----PLVSSITRSSEPVQ------HEESIRKPSPEPRAQMR--- 974
Query: 909 RIDSPGFKPASQQKAEASSPVPYLSPETNPASS---------TSAVNHNVNLTNVRLEEP 959
+ AS + +SP P PE A + + + + N + V E
Sbjct: 975 -------RAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNET 1027
Query: 960 TPAPSTSYSPQ-------ADSLRTPST-------EAAHIMLRDQEPSLSSHVDPTKVYRK 1005
A + Y P S+ PST E +Q+ + S + K++ K
Sbjct: 1028 PGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEK 1087
Query: 1006 DPYPEEMMRQNHVLK------QPAVSHPG--------HRPD---------KEPNLTYEPQ 1042
+ + R + + + A HP H+PD + P P
Sbjct: 1088 MDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPS 1147
Query: 1043 LPYVEKQAS--RDLEQPTYRYESSSYTDQFSRNYEHRLRYED 1082
PY + + S D E+ YR + S ++ + Y RY D
Sbjct: 1148 RPYQDTRGSYGSDAEEEEYRQQLSEHSKR--GYYGQSARYRD 1187
Score = 157 bits (398), Expect = 7e-38
Identities = 95/184 (51%), Positives = 117/184 (63%), Gaps = 18/184 (9%)
Query: 9 KSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQ 68
++ MEE IWEQ+TVTL + GFGIA+SGGRDNPHF++GETSIVISDVL GGPA+G
Sbjct: 20 RAPGMEEL-IWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGL 78
Query: 69 LQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNE 128
LQENDRV MVNG M++V H+FAVQQLRKSGK A I ++R +KVQ+ + P D+
Sbjct: 79 LQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDR 138
Query: 129 EDSYDEEIHDPRSGRSGVVNR---------------RSEKIWPRDRSASRERSLS-PRSD 172
+E D RS RSG R E+ P +R+ SRER LS RS
Sbjct: 139 AFEVMDEF-DGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSR 197
Query: 173 RRSV 176
RS+
Sbjct: 198 GRSL 201
Score = 63.2 bits (152), Expect = 2e-09
Identities = 73/285 (25%), Positives = 118/285 (41%), Gaps = 40/285 (14%)
Query: 1089 EQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQ 1148
E +Y D++ P+ P + ++ + QH E +P+P + R + +
Sbjct: 928 EGGAYTDNELDEPAEEPLVSSITRSSEPVQHEES---------IRKPSP---EPRAQMRR 975
Query: 1149 APRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFT 1208
A + LR P P +P P + + Y +S+SYE +
Sbjct: 976 AASSDQLRDNSPP-----------PAFKPEPPKAKTQNKEESY--DFSKSYEY--KSNPS 1020
Query: 1209 SRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEE-----EDPAMKPQS 1263
+ AG+ P PP + + KP S KP P P Q EE E+ P+S
Sbjct: 1021 AVAGNETPGASTKGYPPPVAA---KPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKS 1077
Query: 1264 VLTRVKMFENK-RSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKT 1322
VL +VK+FE A L+ +++ + + + E+A K + P T + T
Sbjct: 1078 VLGKVKIFEKMDHKARLQRMQELQEAQNARI-EIAQKHPDIYAV-PIKTHKPDPGTPQHT 1135
Query: 1323 LYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSF 1367
R PEPQK +P +D S Y + +EE YR+QLS +R +
Sbjct: 1136 SSRPPEPQKAPSRPYQDTRGS--YGSDAEEEEYRQQLSEHSKRGY 1178
Score = 45.8 bits (107), Expect = 4e-04
Identities = 64/271 (23%), Positives = 104/271 (38%), Gaps = 70/271 (25%)
Query: 52 TSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKS-GKNAKITIRR 108
+ I + ++ + G A +G L E D + +NG +N+ A + + KS GK + +R
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 109 KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRER--- 165
++ I + S N+ DS E+I + S RS R + D +S E+
Sbjct: 385 SQQTLINIP-------SLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKE 437
Query: 166 SLSPRSDRRSVASSQPAKPT---------------------------------------- 185
S R D S S A PT
Sbjct: 438 RPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLR 497
Query: 186 -----------KVTLVKSRKNEEYGLRLAS----HIFVKEISQDSLAARDGNIQEGDVVL 230
+V+ +K + GLRLA IFV I + + A ++G +QEGD +L
Sbjct: 498 PSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEG-LQEGDQIL 556
Query: 231 KINGTVTENMSLTDAKT-LIERSKGKLKMVV 260
K+N + DA L+E KG++ ++
Sbjct: 557 KVNTQDFRGLVREDAVLYLLEIPKGEMVTIL 587
Score = 44.7 bits (104), Expect = 8e-04
Identities = 74/304 (24%), Positives = 112/304 (36%), Gaps = 53/304 (17%)
Query: 220 DGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER---ATLLNVPDLSD 276
DG +QE D V+ +NGT E++ + A + +S +VV+R + A L P L
Sbjct: 76 DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQ 135
Query: 277 SIHSANASERDDISEIQSLASD------HSGRSHD--------RPPRRSRSRSPDQRSEP 322
+ + D +S S+ H GRS RP R+RSR D S
Sbjct: 136 DDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERD-LSRD 194
Query: 323 SDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSL 382
R + R+RD R ++ DH + +R+ ++
Sbjct: 195 RSRGRSLERGLDQDHARTRDRSR-------GRSLERGLDHDFGPSRDRDRDRSRGRSID- 246
Query: 383 PEPKPVYAQVGQPDVDLPVSP-----------SDGVLPNSTHEDGILRPS---------- 421
+ + Y + PD + SP S G S PS
Sbjct: 247 QDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPI 306
Query: 422 -MKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
+ L+K R + GLRL IFV + A K+G L EGD IL++N N+
Sbjct: 307 GVLLMKSRANEEYGLRLGS----QIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMS 362
Query: 480 REEA 483
+A
Sbjct: 363 LTDA 366
Score = 33.1 bits (74), Expect = 2.4
Identities = 25/102 (24%), Positives = 45/102 (44%), Gaps = 9/102 (8%)
Query: 14 EETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQ-LQEN 72
E+ AI+ +T + G G+ ++GG D I ++ + +G AE + LQE
Sbjct: 501 EDEAIYGPNTKMVRFKKGDSVGLRLAGGND--------VGIFVAGIQEGTSAEQEGLQEG 552
Query: 73 DRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQI 114
D++ VN + AV L + K +TI + + +
Sbjct: 553 DQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADV 594
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 747 bits (1929), Expect = 0.0
Identities = 427/808 (52%), Positives = 540/808 (66%), Gaps = 77/808 (9%)
Query: 134 EEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSR 193
E + P R + RS PR RS S SP + R +P P V L+KSR
Sbjct: 262 ERAYSPEYRRGARHDARSRG--PRSRSREHPHSRSPSPEPRG----RPG-PIGVLLMKSR 314
Query: 194 KNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSK 253
NEEYGLRL S IFVKE+++ LA +DGN+ EGD++LKINGTVTENMSLTDA+ LIE+S+
Sbjct: 315 ANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSR 374
Query: 254 GKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRS 313
GKL++VV RD + TL+N+P L+DS SE +DISEI+S +RS
Sbjct: 375 GKLQLVVLRDSQQTLINIPSLNDS-----DSEIEDISEIES----------------NRS 413
Query: 314 RSPDQRSEP-SDHSRHSPQQPSNGSLRSRDE--ERISKPGAVSTPVKHADDHTPKTVEEV 370
SP++R SD+ HS + SR++ R+S+ GA TP K D V E
Sbjct: 414 FSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPET 473
Query: 371 TVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKG 430
E ++ P P+PK P L SP D + I P+ K+V+F+KG
Sbjct: 474 NKEPRYQEDPPAPQPKAA------PRTFLRPSPED---------EAIYGPNTKMVRFKKG 518
Query: 431 DSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDL 490
DSVGLRLAGGNDVGIFVAG+ E + A +EGL+EGDQIL+VN DF ++RE+AVL+LL++
Sbjct: 519 DSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEI 578
Query: 491 PKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLY 550
PKGE VTILAQ + DVYR I+ GDSF+IR+HFE EKE+P L+F +GEVFRVVDTLY
Sbjct: 579 PKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLY 638
Query: 551 NGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSS 610
+GKLG+WLA+RIG E+E+G+IPNK+RAEQ+ASVQ + GDRADFWR RG RS
Sbjct: 639 DGKLGNWLAVRIG---NELEKGLIPNKSRAEQMASVQ-NAQRDNAGDRADFWRMRGQRSG 694
Query: 611 -KRNLRKSREDLSA-QPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDI 668
K+NLRKSREDL+A V TKFPAYERV+LREAGF RPV +FGPIAD+A EKLA E PD
Sbjct: 695 VKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDW 754
Query: 669 YQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFL 728
+Q AK+EP+DAG+ ++S+G++RL+T++QII+QDKHALLDVTP AVD LNY QW+PIV+F
Sbjct: 755 FQTAKTEPKDAGS-EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFF 813
Query: 729 NPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKE 788
NPDS+QGVKTMR RL P S KS+RKL+++++KL+K HLFT TINLNS ND W+G+LK+
Sbjct: 814 NPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKD 873
Query: 789 AIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDT 848
IQ QQ + VWVSEGK +G D +DR+SYL+A G++Y S DSR SD+EDTD
Sbjct: 874 TIQHQQGEAVWVSEGKMEGMDDDP----EDRMSYLTAMGADY--LSCDSRLISDFEDTDG 927
Query: 849 EGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPI- 907
EGGAYTD ELDE + P S+ITRSSEPV+ HE P PI
Sbjct: 928 EGGAYTDNELDEPAEE----PLVSSITRSSEPVQ-------HEEIEIAQKHPDIYAVPIK 976
Query: 908 -HRIDSPGFKPASQQKAEASSPVPYLSP 934
H+ D P + Q + P P +P
Sbjct: 977 THKPD-----PGTPQHTSSRPPEPQKAP 999
Score = 157 bits (398), Expect = 7e-38
Identities = 95/184 (51%), Positives = 117/184 (63%), Gaps = 18/184 (9%)
Query: 9 KSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQ 68
++ MEE IWEQ+TVTL + GFGIA+SGGRDNPHF++GETSIVISDVL GGPA+G
Sbjct: 20 RAPGMEEL-IWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGL 78
Query: 69 LQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNE 128
LQENDRV MVNG M++V H+FAVQQLRKSGK A I ++R +KVQ+ + P D+
Sbjct: 79 LQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDR 138
Query: 129 EDSYDEEIHDPRSGRSGVVNR---------------RSEKIWPRDRSASRERSLS-PRSD 172
+E D RS RSG R E+ P +R+ SRER LS RS
Sbjct: 139 AFEVMDEF-DGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSR 197
Query: 173 RRSV 176
RS+
Sbjct: 198 GRSL 201
Score = 45.8 bits (107), Expect = 4e-04
Identities = 64/271 (23%), Positives = 104/271 (38%), Gaps = 70/271 (25%)
Query: 52 TSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKS-GKNAKITIRR 108
+ I + ++ + G A +G L E D + +NG +N+ A + + KS GK + +R
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 109 KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRER--- 165
++ I + S N+ DS E+I + S RS R + D +S E+
Sbjct: 385 SQQTLINIP-------SLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKE 437
Query: 166 SLSPRSDRRSVASSQPAKPT---------------------------------------- 185
S R D S S A PT
Sbjct: 438 RPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLR 497
Query: 186 -----------KVTLVKSRKNEEYGLRLAS----HIFVKEISQDSLAARDGNIQEGDVVL 230
+V+ +K + GLRLA IFV I + + A ++G +QEGD +L
Sbjct: 498 PSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEG-LQEGDQIL 556
Query: 231 KINGTVTENMSLTDAKT-LIERSKGKLKMVV 260
K+N + DA L+E KG++ ++
Sbjct: 557 KVNTQDFRGLVREDAVLYLLEIPKGEMVTIL 587
Score = 44.7 bits (104), Expect = 8e-04
Identities = 74/304 (24%), Positives = 112/304 (36%), Gaps = 53/304 (17%)
Query: 220 DGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER---ATLLNVPDLSD 276
DG +QE D V+ +NGT E++ + A + +S +VV+R + A L P L
Sbjct: 76 DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQ 135
Query: 277 SIHSANASERDDISEIQSLASD------HSGRSHD--------RPPRRSRSRSPDQRSEP 322
+ + D +S S+ H GRS RP R+RSR D S
Sbjct: 136 DDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERD-LSRD 194
Query: 323 SDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSL 382
R + R+RD R ++ DH + +R+ ++
Sbjct: 195 RSRGRSLERGLDQDHARTRDRSR-------GRSLERGLDHDFGPSRDRDRDRSRGRSID- 246
Query: 383 PEPKPVYAQVGQPDVDLPVSP-----------SDGVLPNSTHEDGILRPS---------- 421
+ + Y + PD + SP S G S PS
Sbjct: 247 QDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPI 306
Query: 422 -MKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
+ L+K R + GLRL IFV + A K+G L EGD IL++N N+
Sbjct: 307 GVLLMKSRANEEYGLRLGS----QIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMS 362
Query: 480 REEA 483
+A
Sbjct: 363 LTDA 366
Score = 33.9 bits (76), Expect = 1.4
Identities = 19/46 (41%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 1322 TLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSF 1367
T R PEPQK +P +D S Y + +EE YR+QLS +R +
Sbjct: 988 TSSRPPEPQKAPSRPYQDTRGS--YGSDAEEEEYRQQLSEHSKRGY 1031
Score = 33.1 bits (74), Expect = 2.4
Identities = 25/102 (24%), Positives = 45/102 (44%), Gaps = 9/102 (8%)
Query: 14 EETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQ-LQEN 72
E+ AI+ +T + G G+ ++GG D I ++ + +G AE + LQE
Sbjct: 501 EDEAIYGPNTKMVRFKKGDSVGLRLAGGND--------VGIFVAGIQEGTSAEQEGLQEG 552
Query: 73 DRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQI 114
D++ VN + AV L + K +TI + + +
Sbjct: 553 DQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADV 594
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 659 bits (1699), Expect = 0.0
Identities = 406/936 (43%), Positives = 550/936 (58%), Gaps = 130/936 (13%)
Query: 13 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQEN 72
MEE IWEQHT TL + P GFGIAISGGRD P S+V+SDV+ GGPAEG+LQ
Sbjct: 20 MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPG-----GSMVVSDVVPGGPAEGRLQTG 74
Query: 73 DRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS--DNEED 130
D + MVNGVSM+N AFA+Q L+ K A IT++R +++ +P ++ P D++ED
Sbjct: 75 DHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDED 134
Query: 131 SYDEEIHDPRSGRS--GVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ-------- 180
+ + + GR G + S + W ERS PR RR A S
Sbjct: 135 DGPQRVEEVDQGRGYDGDSSSGSGRSWD-------ERSRRPRPGRRGRAGSHGRRSPGGG 187
Query: 181 --------------------PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARD 220
KP K LVK R +EE+G++L S IF+K I+ LAAR
Sbjct: 188 SEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARH 247
Query: 221 GNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPD-LSDSIH 279
+QEGD++L+ING ++N+SL D + LIE+S+GKL ++V RD L+N+P +SDS
Sbjct: 248 RGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDS 307
Query: 280 SA---NASERDDIS----EIQSLASDHSGR--SHDRPPRRSRSRSPDQRSEPSDHSRHSP 330
S + D++S +I LAS+ S SH PP R RSP+ + +D SP
Sbjct: 308 SPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPE--ASQTDSPVESP 365
Query: 331 QQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYA 390
+ S+ SR T+ ++Q LP
Sbjct: 366 RLRRESSVDSR-----------------------------TISEPDEQRSELPR------ 390
Query: 391 QVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV 450
+ D+ PS + + ED P ++V+F KG S+GLRLAGGNDVGIFV+GV
Sbjct: 391 ---ESSYDIYRVPS-----SQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGV 442
Query: 451 LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRI 510
SPA +G++EGDQIL+VN+V F N+ REEAV FLL LP GEE+ ++ Q+K+D++ ++
Sbjct: 443 QAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKM 502
Query: 511 VESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNG------KLGSWLAIRIGK 564
V+S VGDSFYIRTHFE E P GL F +G+VF V+DTL+ G + G WLA+R+G+
Sbjct: 503 VQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGR 562
Query: 565 NHKEVERGIIPNKNRAEQLASVQYTL------PKTAGGD--RADFWRFRGL-RSSKRNLR 615
+ +E ERGIIPN++RAEQLAS++ P ++ G RA+FWR RGL R +K+ +
Sbjct: 563 DLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQ 622
Query: 616 KSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSE 675
+SREDLSA Q ++P YERVVLREA F RPV I GP+AD+A +KL E PD ++IA++
Sbjct: 623 RSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETV 682
Query: 676 PRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQG 735
R TD S II+L T++ I ++DKHALLDVTP+A++RLNY Q+YPIVVF P+S+
Sbjct: 683 SR---TDSPSK-IIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPA 738
Query: 736 VKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQN 795
+K +R L P SR+S R+LY ++ KLRK++ HLFT TI LN +D WY LK I++QQ
Sbjct: 739 LKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQT 798
Query: 796 QLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTD 855
+ +W +E + DG+ D+LDL L+ SA S DSR SDYE TD EGGAYTD
Sbjct: 799 RPIWTAEDQLDGSLEDNLDLPHHGLADSSAD------LSCDSRVNSDYE-TDGEGGAYTD 851
Query: 856 QE-----LDETLNDEVGTPPESAITRSSEPVREDSS 886
E D PP A+ RSSEPV+ D S
Sbjct: 852 GEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADES 887
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 150 bits (379), Expect = 1e-35
Identities = 164/686 (23%), Positives = 274/686 (39%), Gaps = 127/686 (18%)
Query: 204 SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRD 263
S IF+ +I AA+DG ++ D +L++N +++ + A ++ + +++ V+R
Sbjct: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
Query: 264 ERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPS 323
+ + + I EI+ L G P S
Sbjct: 311 KPVS-------------------EKIMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYV 350
Query: 324 DHSRHSPQQPSNGSLRSRDE---------ERISKPGAVSTPVKHADDHTPKTVEEVTVER 374
+G L+ D+ E ++ AV+ +D K + ++
Sbjct: 351 TKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYM 410
Query: 375 NEKQTPSLPEPKPVYAQVGQPDVDLPVSPSD--GVLPNSTH-----------EDGILRPS 421
N+ P P VD VSPS G P S +D I R
Sbjct: 411 NDGYAP------PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREP 464
Query: 422 MKLVKFRKGDSVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
K+V R +G + GG D GIF++ +L PA G L +GD+I+ VN+VD
Sbjct: 465 RKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD---------------------- 517
E+A L + G+ VTI+AQ + + Y R E+ + D
Sbjct: 525 HEQAAAALKNA--GQAVTIVAQYRPEEYSRF-EAKIHDLREQMMNSSISSGSGSLRTSQK 581
Query: 518 -SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVER 571
S Y+R F+Y+K GL+F G++ V++ + W A ++ + + E
Sbjct: 582 RSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEW---WQARQVTPDGESDEV 638
Query: 572 GIIPNKNRAEQ-----LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPV 626
G+IP+K R E+ L +V++ G+ D +GL+ N S Q
Sbjct: 639 GVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQ-- 696
Query: 627 QTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIAKSEPRDAGTD 682
+ +YE V +E + RPV I GP+ D + L E PD + RD D
Sbjct: 697 EEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVD 756
Query: 683 QRSSGII----------------------------RLHTIKQIIDQDKHALLDVTPNAVD 714
R + + +++++ ++ KH +LDV+ NA+
Sbjct: 757 GRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIK 816
Query: 715 RLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTIN 774
RL AQ YPI +F+ P S + + M RL E ARK +ER+ KL + FT +
Sbjct: 817 RLQIAQLYPISIFIKPKSMENIMEMNKRLTEE---QARKTFERAMKLEQEFTEHFTAIVQ 873
Query: 775 LNSMNDGWYGALKEAIQQQQNQLVWV 800
+++ D Y +K+ I++Q +WV
Sbjct: 874 GDTLED-IYNQVKQIIEEQSGSYIWV 898
Score = 65.1 bits (157), Expect = 6e-10
Identities = 36/98 (36%), Positives = 61/98 (62%), Gaps = 4/98 (4%)
Query: 17 AIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDR 74
A +E +TL R G G +I+GG DNPH ++SI I+ ++ GG A +G+L+ ND
Sbjct: 218 ADYEYEEITLERGNS-GLGFSIAGGTDNPHI-GDDSSIFITKIITGGAAAQDGRLRVNDC 275
Query: 75 VAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
+ VN V + +V H+ AV+ L+++G ++ ++R+K V
Sbjct: 276 ILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Score = 48.9 bits (115), Expect = 4e-05
Identities = 52/234 (22%), Positives = 93/234 (39%), Gaps = 22/234 (9%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V ++ V H
Sbjct: 328 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
Query: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
AV L+ + + + + + + P+ + + + V N
Sbjct: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQP---------------VDNHV 431
Query: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
S + AS R SP S +P KV L + + G IF
Sbjct: 432 SPSSFLGQTPASPAR-YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIF 490
Query: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
+ I A G +++GD ++ +N S A ++ + + +V Q
Sbjct: 491 ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
Score = 47.0 bits (110), Expect = 2e-04
Identities = 42/135 (31%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
+K+ ++ E V LHR G G I GG D GE I IS +L GGPA+
Sbjct: 451 SKAVLGDDEITREPRKVVLHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 502
Query: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
G+L++ DR+ VN V + H A L+ +G+ I V++ PE
Sbjct: 503 SGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI-----------VAQYRPE--- 548
Query: 126 DNEEDSYDEEIHDPR 140
E ++ +IHD R
Sbjct: 549 --EYSRFEAKIHDLR 561
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 150 bits (379), Expect = 1e-35
Identities = 122/424 (28%), Positives = 206/424 (48%), Gaps = 48/424 (11%)
Query: 418 LRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPA-AKEGLEEGDQILRVNNVDFT 476
L P + +K + +G+ L GGN G+FVA V +DSPA +GL GD IL ++D
Sbjct: 1498 LEPRVVFIK-KSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVR 1556
Query: 477 NIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLS 536
N EE + +L G V + Q + + + + + GDSFYIR ++ + LS
Sbjct: 1557 NKTVEEVYVEMLKPRDG--VRLKVQYRPEEFTK-AKGLPGDSFYIRALYDRLADVEQELS 1613
Query: 537 FNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKT--- 593
F K ++ V DTL G GSW+A ++ +N ++++RG IP+K +Q S + ++ +
Sbjct: 1614 FKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDD 1673
Query: 594 -------AGGDRADFWRFRGLRSSKRNLRKSREDLSAQPV--QTKFP--------AYERV 636
+ R F FR KR+ K +DL A P AY+RV
Sbjct: 1674 NSATKTLSAAARRSF--FRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRV 1731
Query: 637 VLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD-------------- 682
+ LRPV I GP+ DV +E L E P + E A
Sbjct: 1732 QKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDY 1791
Query: 683 QRSSG---IIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTM 739
+R SG + + +IK+I ++++H LLD+ P+A++RL++ YPIV+F++ S + +K
Sbjct: 1792 KRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQ 1851
Query: 740 RMRLC---PESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQ 796
R + +++ +++ +E + KL + FT I +++ L + Q+QN+
Sbjct: 1852 RDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQIL-AMVNQEQNK 1910
Query: 797 LVWV 800
++W+
Sbjct: 1911 VLWI 1914
Score = 50.4 bits (119), Expect = 1e-05
Identities = 60/218 (27%), Positives = 93/218 (42%), Gaps = 19/218 (8%)
Query: 299 HSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKH 358
H GR R+ S + R+ +S S + + S ERI P STP
Sbjct: 1227 HQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIP---STP--- 1280
Query: 359 ADDHTPKTV---EEVTVERNEKQTP-SLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHE 414
P++V E +V +E TP P + Q P V P S E
Sbjct: 1281 ---RYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGE 1337
Query: 415 DGILRPSM---KLVKFRKG-DSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRV 470
RP + + VK +KG + +G+ + G GI+V+ V S A + GLE GDQ+L
Sbjct: 1338 RRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEF 1397
Query: 471 NNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR 508
N ++ + ++A L + + + +TILAQ V++
Sbjct: 1398 NGINLRSATEQQARLIIGQ--QCDTITILAQYNPHVHQ 1433
Score = 39.3 bits (90), Expect = 0.034
Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 9/122 (7%)
Query: 2 SARAAAAKSTAMEETAIWEQHTVTLHRAPGF----GFGIAISGGRDNPHFQSGETSIVIS 57
S+ +A + +ME WE V R G ++ G + P F G+ I ++
Sbjct: 603 SSHDSAIDTDSME----WETEVVEFERETEDIDLKALGFDMAEGVNEPCFP-GDCGIFVT 657
Query: 58 DVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVS 117
V KG A+G+L+ ND + +N V + N + A++ L + +RR+K + V
Sbjct: 658 KVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVV 717
Query: 118 RP 119
P
Sbjct: 718 TP 719
Score = 34.7 bits (78), Expect = 0.84
Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 1/35 (2%)
Query: 444 GIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTN 477
G++ A VL SPAAKEG L GD+I+ +N + N
Sbjct: 737 GVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDN 771
Score = 34.3 bits (77), Expect = 1.1
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 4/52 (7%)
Query: 36 IAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDN 85
I +SG +D+ S E + + VL G PA EG L DR+ +NG+++DN
Sbjct: 722 INLSGQKDSGI--SLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDN 771
Score = 33.1 bits (74), Expect = 2.4
Identities = 33/123 (26%), Positives = 64/123 (52%), Gaps = 22/123 (17%)
Query: 407 VLPNSTHEDGILRPSMK----LVKF-RKGDSVGLRLAGGN------------DVGIFVAG 449
++ +S+H+ I SM+ +V+F R+ + + L+ G + D GIFV
Sbjct: 599 LMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTK 658
Query: 450 VLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGE-EVTILAQKKKDVYR 508
V + S A L D +LR+N+VD N +++A+ LL+ GE + ++ +++K +
Sbjct: 659 VDKGS-IADGRLRVNDWLLRINDVDLINKDKKQAIKALLN---GEGAINMVVRRRKSLGG 714
Query: 509 RIV 511
++V
Sbjct: 715 KVV 717
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 141 bits (356), Expect = 5e-33
Identities = 166/706 (23%), Positives = 280/706 (39%), Gaps = 145/706 (20%)
Query: 204 SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRD 263
S IF+ +I AA+DG ++ D +L++N +++ + A ++ + +++ V+R
Sbjct: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
Query: 264 ERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPS 323
+ + + I EI+ L G P S
Sbjct: 311 KPVS-------------------EKIMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYV 350
Query: 324 DHSRHSPQQPSNGSLRSRDE---------ERISKPGAVSTPVKHADDHTPKTVEEVTVER 374
+G L+ D+ E ++ AV+ +D K + ++
Sbjct: 351 TKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYM 410
Query: 375 NEKQTPSLPEPKPVYAQVGQPDVDLPVSPSD--GVLPNSTH-----------EDGILRPS 421
N+ P P VD VSPS G P S +D I R
Sbjct: 411 NDGYAP------PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREP 464
Query: 422 MKLVKFRKGDSVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
K+V R +G + GG D GIF++ +L PA G L +GD+I+ VN+VD
Sbjct: 465 RKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD---------------------- 517
E+A L + G+ VTI+AQ + + Y R E+ + D
Sbjct: 525 HEQAAAALKNA--GQAVTIVAQYRPEEYSRF-EAKIHDLREQMMNSSISSGSGSLRTSQK 581
Query: 518 -SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVER 571
S Y+R F+Y+K GL+F G++ V++ + W A ++ + + E
Sbjct: 582 RSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEW---WQARQVTPDGESDEV 638
Query: 572 GIIPNKNRAEQ-----LASVQYTLPKTAGGDRADFWRFRGLRSSK----RNLRKSREDLS 622
G+IP+K R E+ L +V++ G + R + L S K +N +S ++ S
Sbjct: 639 GVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETS 698
Query: 623 ---------AQPVQTKFPAYERVVL-------REAGFLRPVTIFGPIADVAREKLAREEP 666
A ++ + E VL +E + RPV I GP+ D + L E P
Sbjct: 699 DADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFP 758
Query: 667 DIY----QIAKSEPRDAGTDQRSSGII----------------------------RLHTI 694
D + RD D R + + ++
Sbjct: 759 DKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSV 818
Query: 695 KQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKL 754
+++ ++ KH +LDV+ NA+ RL AQ YPI +F+ P S + + M RL E ARK
Sbjct: 819 REVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEE---QARKT 875
Query: 755 YERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
+ER+ KL + FT + +++ D Y +K+ I++Q +WV
Sbjct: 876 FERAMKLEQEFTEHFTAIVQGDTLED-IYNQVKQIIEEQSGSYIWV 920
Score = 65.1 bits (157), Expect = 6e-10
Identities = 36/98 (36%), Positives = 61/98 (62%), Gaps = 4/98 (4%)
Query: 17 AIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDR 74
A +E +TL R G G +I+GG DNPH ++SI I+ ++ GG A +G+L+ ND
Sbjct: 218 ADYEYEEITLERGNS-GLGFSIAGGTDNPHI-GDDSSIFITKIITGGAAAQDGRLRVNDC 275
Query: 75 VAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
+ VN V + +V H+ AV+ L+++G ++ ++R+K V
Sbjct: 276 ILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Score = 48.9 bits (115), Expect = 4e-05
Identities = 52/234 (22%), Positives = 93/234 (39%), Gaps = 22/234 (9%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V ++ V H
Sbjct: 328 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
Query: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
AV L+ + + + + + + P+ + + + V N
Sbjct: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQP---------------VDNHV 431
Query: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
S + AS R SP S +P KV L + + G IF
Sbjct: 432 SPSSFLGQTPASPAR-YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIF 490
Query: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
+ I A G +++GD ++ +N S A ++ + + +V Q
Sbjct: 491 ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
Score = 47.0 bits (110), Expect = 2e-04
Identities = 42/135 (31%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
+K+ ++ E V LHR G G I GG D GE I IS +L GGPA+
Sbjct: 451 SKAVLGDDEITREPRKVVLHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 502
Query: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
G+L++ DR+ VN V + H A L+ +G+ I V++ PE
Sbjct: 503 SGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI-----------VAQYRPE--- 548
Query: 126 DNEEDSYDEEIHDPR 140
E ++ +IHD R
Sbjct: 549 --EYSRFEAKIHDLR 561
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 140 bits (353), Expect = 1e-32
Identities = 160/676 (23%), Positives = 271/676 (40%), Gaps = 105/676 (15%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDE- 264
IF+ +I AA DG + D VL++N + + A ++ + +++VV+R +
Sbjct: 160 IFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQP 219
Query: 265 ------RATLLNVPD-LSDSIHSANASER---DDISEIQSLASDHSGRSHDRPPRRSRSR 314
LL P L SI ++ D+ I + + + R R
Sbjct: 220 PPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLL 279
Query: 315 SPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVER 374
+ + + RH S + +++KPG++ +A T + +
Sbjct: 280 AVNNTN--LQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALA-DN 336
Query: 375 NEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTH---EDGILRPSMKLVKFRKGD 431
+ SL V ++V P P P P H E+ R K++ +
Sbjct: 337 HISHNSSLGYLGAVESKVSYPAP--PQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGST 394
Query: 432 SVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLD 489
+G + GG D GIFV+ +L PA G L GD+IL VN V+ N E+A L
Sbjct: 395 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKR 454
Query: 490 LPKGEEVTILAQKKKDVYRRIVESDVGD-----------------------SFYIRTHFE 526
G+ VTI+AQ + + Y R ES + D S Y+R F+
Sbjct: 455 A--GQSVTIVAQYRPEEYSRF-ESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFD 511
Query: 527 YEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVER-GIIPNKNRA 580
Y++ GLSF+ G++ V+ N W R+ H E E+ G+IP+K R
Sbjct: 512 YDRTRDSCLPSQGLSFSYGDILHVI----NASDDEWWQARLVTPHGESEQIGVIPSKKRV 567
Query: 581 EQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDL----SAQPVQTKFPAYERV 636
E+ + K F G+ S R+ +D + + + +YE V
Sbjct: 568 EKKERARLKTVK--------FHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPV 619
Query: 637 VLREAGFLRPVTIFGPIADVAREKLAREEP----------------------DIYQIAKS 674
+E + RPV I GP+ D + L E P D + +
Sbjct: 620 TRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSR 679
Query: 675 EPR----------DAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPI 724
E +AG + + +++ + ++ KH +LDV+ NA+ RL AQ YPI
Sbjct: 680 EQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPI 739
Query: 725 VVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYG 784
+F+ P S + + M R ++ + A K+Y+++ KL + FT + +S+ + Y
Sbjct: 740 AIFIKPKSIEALMEMNRR---QTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEE-IYN 795
Query: 785 ALKEAIQQQQNQLVWV 800
+K+ I+ Q +WV
Sbjct: 796 KIKQIIEDQSGHYIWV 811
Score = 63.9 bits (154), Expect = 1e-09
Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 9/234 (3%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG N H G+ SI I+ +++GG A+ G+LQ DR+ VN ++ +V H
Sbjct: 235 GLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEE 293
Query: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
AV L+ + + + + + + P+ S + + H+ G G V +
Sbjct: 294 AVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK 353
Query: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGL---RLASHIF 207
P +R SP +P K+ L K + + IF
Sbjct: 354 VSYPAPPQVPPTR---YSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIF 410
Query: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
V I A G ++ GD +L +NG N + A ++R+ + +V Q
Sbjct: 411 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQ 464
Score = 57.0 bits (136), Expect = 2e-07
Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 11/96 (11%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG DNPH + I I+ ++ GG A +G+L ND V VN V + V H+
Sbjct: 140 GLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSR 198
Query: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSD 126
AV+ L+++G ++ +RR+ +P PE + +
Sbjct: 199 AVEALKEAGPVVRLVVRRR--------QPPPETIME 226
Score = 52.8 bits (125), Expect = 3e-06
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 26/129 (20%)
Query: 14 EETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQE 71
EE E + LH+ G G I GG D GE I +S +L GGPA+ G+L+
Sbjct: 377 EEDFTREPRKIILHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELRR 428
Query: 72 NDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDS 131
DR+ VNGV++ N H A L+++G++ I V++ PE E
Sbjct: 429 GDRILSVNGVNLRNATHEQAAAALKRAGQSVTI-----------VAQYRPE-----EYSR 472
Query: 132 YDEEIHDPR 140
++ +IHD R
Sbjct: 473 FESKIHDLR 481
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 138 bits (348), Expect = 4e-32
Identities = 128/475 (26%), Positives = 196/475 (41%), Gaps = 96/475 (20%)
Query: 389 YAQVGQPDVDLPVSPS--DGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGND-VGI 445
Y P P SP V + E+ I R ++V R +G + GG D GI
Sbjct: 320 YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGI 379
Query: 446 FVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKK 504
F++ +L PA G L +GDQIL VN VD N E+A + L + G+ VTI+AQ K
Sbjct: 380 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTIIAQYKP 437
Query: 505 DVYRR-----------IVESDVGDS-----------FYIRTHFEYEKESPYG-----LSF 537
+ Y R ++ S +G FYIR F+Y+K G LSF
Sbjct: 438 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 497
Query: 538 NKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGD 597
G+V V+D W A R+ + + + G IP+K R E
Sbjct: 498 RFGDVLHVIDA---SDEEWWQARRVHSDSETDDIGFIPSKRRVE---------------- 538
Query: 598 RADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVA 657
R ++ R + + + RED +YE V E + RP+ I GP D A
Sbjct: 539 RREWSRLKAKDWGSSSGSQGRED--------SVLSYETVTQMEVHYARPIIILGPTKDRA 590
Query: 658 REKLAREEPD--------------IYQIAKSEPRDAGTDQRSSGIIRLH----------- 692
+ L E PD Y+I + + ++ I+ H
Sbjct: 591 NDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH 650
Query: 693 -------TIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCP 745
+++++ +Q KH +LDV+ NAV RL A +PI +F+ P S + V + R+
Sbjct: 651 LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITE 710
Query: 746 ESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
E ARK ++R+ KL + F+ + +S + Y +K I+ +WV
Sbjct: 711 E---QARKAFDRATKLEQEFTECFSAIVEGDSFEE-IYHKVKRVIEDLSGPYIWV 761
Score = 63.5 bits (153), Expect = 2e-09
Identities = 51/234 (21%), Positives = 98/234 (41%), Gaps = 16/234 (6%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V +++V H
Sbjct: 212 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED 270
Query: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
AV L+ + + + + + S P+ + + +E H G
Sbjct: 271 AVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD------ 324
Query: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
+P + + R SP + P +P ++ + + + G IF
Sbjct: 325 ----YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIF 380
Query: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
+ I A G +++GD +L +NG N S A ++ + + ++ Q
Sbjct: 381 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Score = 62.0 bits (149), Expect = 5e-09
Identities = 34/93 (36%), Positives = 55/93 (59%), Gaps = 4/93 (4%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAM 77
E +TL R G G +I+GG DNPH + SI I+ ++ GG A +G+L+ ND +
Sbjct: 105 EYEEITLERGNS-GLGFSIAGGTDNPHI-GDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
Query: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKK 110
VN V + V H+ AV+ L+++G ++ + R+K
Sbjct: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK 195
Score = 52.0 bits (123), Expect = 5e-06
Identities = 44/135 (32%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
AK EE E + +HR G G I GG D GE I IS +L GGPA+
Sbjct: 341 AKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 392
Query: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
G+L++ D++ VNGV + N H A L+ +G+ I + K PE
Sbjct: 393 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYK-----------PE--- 438
Query: 126 DNEEDSYDEEIHDPR 140
E ++ +IHD R
Sbjct: 439 --EYSRFEAKIHDLR 451
Score = 42.0 bits (97), Expect = 0.005
Identities = 28/74 (37%), Positives = 43/74 (58%), Gaps = 10/74 (13%)
Query: 422 MKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNV 473
+KL+K KG +G +AGG D I+V ++E A K+G L+ GD+IL VN+V
Sbjct: 204 IKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 261
Query: 474 DFTNIIREEAVLFL 487
+++ E+AV L
Sbjct: 262 GLEDVMHEDAVAAL 275
Score = 36.6 bits (83), Expect = 0.22
Identities = 26/105 (24%), Positives = 47/105 (44%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
I+V +I + A +DG +Q GD +L +N E++ DA ++ + + + V +
Sbjct: 232 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
Query: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRR 310
A L + D S + ++IS L +D+ PRR
Sbjct: 292 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 336
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 138 bits (348), Expect = 4e-32
Identities = 128/475 (26%), Positives = 196/475 (41%), Gaps = 96/475 (20%)
Query: 389 YAQVGQPDVDLPVSPS--DGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGND-VGI 445
Y P P SP V + E+ I R ++V R +G + GG D GI
Sbjct: 274 YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGI 333
Query: 446 FVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKK 504
F++ +L PA G L +GDQIL VN VD N E+A + L + G+ VTI+AQ K
Sbjct: 334 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTIIAQYKP 391
Query: 505 DVYRR-----------IVESDVGDS-----------FYIRTHFEYEKESPYG-----LSF 537
+ Y R ++ S +G FYIR F+Y+K G LSF
Sbjct: 392 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 451
Query: 538 NKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGD 597
G+V V+D W A R+ + + + G IP+K R E
Sbjct: 452 RFGDVLHVIDA---SDEEWWQARRVHSDSETDDIGFIPSKRRVE---------------- 492
Query: 598 RADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVA 657
R ++ R + + + RED +YE V E + RP+ I GP D A
Sbjct: 493 RREWSRLKAKDWGSSSGSQGRED--------SVLSYETVTQMEVHYARPIIILGPTKDRA 544
Query: 658 REKLAREEPD--------------IYQIAKSEPRDAGTDQRSSGIIRLH----------- 692
+ L E PD Y+I + + ++ I+ H
Sbjct: 545 NDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH 604
Query: 693 -------TIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCP 745
+++++ +Q KH +LDV+ NAV RL A +PI +F+ P S + V + R+
Sbjct: 605 LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITE 664
Query: 746 ESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
E ARK ++R+ KL + F+ + +S + Y +K I+ +WV
Sbjct: 665 E---QARKAFDRATKLEQEFTECFSAIVEGDSFEE-IYHKVKRVIEDLSGPYIWV 715
Score = 63.5 bits (153), Expect = 2e-09
Identities = 51/234 (21%), Positives = 98/234 (41%), Gaps = 16/234 (6%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V +++V H
Sbjct: 166 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED 224
Query: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
AV L+ + + + + + S P+ + + +E H G
Sbjct: 225 AVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD------ 278
Query: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
+P + + R SP + P +P ++ + + + G IF
Sbjct: 279 ----YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIF 334
Query: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
+ I A G +++GD +L +NG N S A ++ + + ++ Q
Sbjct: 335 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
Score = 62.0 bits (149), Expect = 5e-09
Identities = 34/93 (36%), Positives = 55/93 (59%), Gaps = 4/93 (4%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAM 77
E +TL R G G +I+GG DNPH + SI I+ ++ GG A +G+L+ ND +
Sbjct: 59 EYEEITLERGNS-GLGFSIAGGTDNPHI-GDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116
Query: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKK 110
VN V + V H+ AV+ L+++G ++ + R+K
Sbjct: 117 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK 149
Score = 52.0 bits (123), Expect = 5e-06
Identities = 44/135 (32%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
AK EE E + +HR G G I GG D GE I IS +L GGPA+
Sbjct: 295 AKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 346
Query: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
G+L++ D++ VNGV + N H A L+ +G+ I + K PE
Sbjct: 347 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYK-----------PE--- 392
Query: 126 DNEEDSYDEEIHDPR 140
E ++ +IHD R
Sbjct: 393 --EYSRFEAKIHDLR 405
Score = 42.0 bits (97), Expect = 0.005
Identities = 28/74 (37%), Positives = 43/74 (58%), Gaps = 10/74 (13%)
Query: 422 MKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNV 473
+KL+K KG +G +AGG D I+V ++E A K+G L+ GD+IL VN+V
Sbjct: 158 IKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 215
Query: 474 DFTNIIREEAVLFL 487
+++ E+AV L
Sbjct: 216 GLEDVMHEDAVAAL 229
Score = 36.6 bits (83), Expect = 0.22
Identities = 26/105 (24%), Positives = 47/105 (44%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
I+V +I + A +DG +Q GD +L +N E++ DA ++ + + + V +
Sbjct: 186 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 245
Query: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRR 310
A L + D S + ++IS L +D+ PRR
Sbjct: 246 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 290
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 138 bits (347), Expect = 5e-32
Identities = 165/696 (23%), Positives = 267/696 (38%), Gaps = 154/696 (22%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
I+V +I A +DG +Q GD +L +N E ++ +A +++ + + + V +
Sbjct: 327 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 386
Query: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDH 325
+ + D HS + PP + S +
Sbjct: 387 IYMTDPYGPPDITHSYS------------------------PPMENHLLSGN-------- 414
Query: 326 SRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHA---DDHT--PKTVEEVTVERNEKQTP 380
NG+L + PG S KH DD+T P+ V + +K P
Sbjct: 415 ---------NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDK--P 463
Query: 381 SLPE-------PKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKL--------- 424
+ P K L + P + +S H +PSM L
Sbjct: 464 ASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 523
Query: 425 ---VKFRKGDS-VGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNI 478
V KG + +G + GG D GIFV+ +L PA G L+ GDQIL VN +D
Sbjct: 524 PRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 583
Query: 479 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD--------------------- 517
E+A L G+ VTI+AQ + + Y R E+ + D
Sbjct: 584 SHEQAAAALKGA--GQTVTIIAQYQPEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQ 640
Query: 518 --SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVE 570
S Y+R F+Y+K GLSF G++ V++ + W A R+ E
Sbjct: 641 KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEE 697
Query: 571 RGIIPNKNRAEQ-----LASVQYTLPKTAGGDRADF-------WRFRGLRSSKRNLRKSR 618
G+IP+K R E+ L +V++ + F + F +N +S
Sbjct: 698 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSE 757
Query: 619 EDLS--AQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIA 672
++ S + + +YE V +E + RPV I GP+ D + L E PD +
Sbjct: 758 QETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHT 817
Query: 673 KSEPRDAGTDQRSSGII----------------------------RLHTIKQIIDQDKHA 704
RD D R + + +++ + ++ KH
Sbjct: 818 TRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHC 877
Query: 705 LLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKN 764
+LDV+ NA+ RL AQ YPI +F+ P S + + M RL E A+K Y+R+ KL +
Sbjct: 878 ILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE---QAKKTYDRAIKLEQE 934
Query: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
FT + +++ D Y K I++Q +W+
Sbjct: 935 FGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 969
Score = 62.0 bits (149), Expect = 5e-09
Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)
Query: 19 WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76
+E +TL R G G +I+GG DNPH + I I+ ++ GG A +G+L+ ND +
Sbjct: 199 YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 256
Query: 77 MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
VN V + V H+ AV+ L+++G ++ +RR++ +
Sbjct: 257 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 292
Score = 51.2 bits (121), Expect = 9e-06
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 5/92 (5%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG N H G+ SI ++ ++ GG A+ G+LQ DR+ MVN S++ V H
Sbjct: 307 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 365
Query: 91 AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD 120
AV L+ + + + + + + + P PD
Sbjct: 366 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 397
Score = 46.6 bits (109), Expect = 2e-04
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAM 77
E V LH+ G G I GG D GE I +S +L GGPA+ G+LQ D++
Sbjct: 523 EPRKVVLHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 574
Query: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKI 104
VNG+ + H A L+ +G+ I
Sbjct: 575 VNGIDLRGASHEQAAAALKGAGQTVTI 601
Score = 42.0 bits (97), Expect = 0.005
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)
Query: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
R +G +AGG +D GIF+ ++ AA++G L D ILRVN VD + +
Sbjct: 208 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 267
Query: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
+AV L + G V + ++++ + +VE
Sbjct: 268 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 298
Score = 40.8 bits (94), Expect = 0.012
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)
Query: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468
IL +++ F+ +G +AGG D I+V +++ A K+G L+ GD++L
Sbjct: 292 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 351
Query: 469 RVNNVDFTNIIREEAVLFL 487
VNN + EEAV L
Sbjct: 352 MVNNYSLEEVTHEEAVAIL 370
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 138 bits (347), Expect = 5e-32
Identities = 165/696 (23%), Positives = 267/696 (38%), Gaps = 154/696 (22%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
I+V +I A +DG +Q GD +L +N E ++ +A +++ + + + V +
Sbjct: 222 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 281
Query: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDH 325
+ + D HS + PP + S +
Sbjct: 282 IYMTDPYGPPDITHSYS------------------------PPMENHLLSGN-------- 309
Query: 326 SRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHA---DDHT--PKTVEEVTVERNEKQTP 380
NG+L + PG S KH DD+T P+ V + +K P
Sbjct: 310 ---------NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDK--P 358
Query: 381 SLPE-------PKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKL--------- 424
+ P K L + P + +S H +PSM L
Sbjct: 359 ASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 418
Query: 425 ---VKFRKGDS-VGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNI 478
V KG + +G + GG D GIFV+ +L PA G L+ GDQIL VN +D
Sbjct: 419 PRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 478
Query: 479 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD--------------------- 517
E+A L G+ VTI+AQ + + Y R E+ + D
Sbjct: 479 SHEQAAAALKGA--GQTVTIIAQYQPEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQ 535
Query: 518 --SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVE 570
S Y+R F+Y+K GLSF G++ V++ + W A R+ E
Sbjct: 536 KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEE 592
Query: 571 RGIIPNKNRAEQ-----LASVQYTLPKTAGGDRADF-------WRFRGLRSSKRNLRKSR 618
G+IP+K R E+ L +V++ + F + F +N +S
Sbjct: 593 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSE 652
Query: 619 EDLS--AQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIA 672
++ S + + +YE V +E + RPV I GP+ D + L E PD +
Sbjct: 653 QETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHT 712
Query: 673 KSEPRDAGTDQRSSGII----------------------------RLHTIKQIIDQDKHA 704
RD D R + + +++ + ++ KH
Sbjct: 713 TRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHC 772
Query: 705 LLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKN 764
+LDV+ NA+ RL AQ YPI +F+ P S + + M RL E A+K Y+R+ KL +
Sbjct: 773 ILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE---QAKKTYDRAIKLEQE 829
Query: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
FT + +++ D Y K I++Q +W+
Sbjct: 830 FGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 864
Score = 62.0 bits (149), Expect = 5e-09
Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)
Query: 19 WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76
+E +TL R G G +I+GG DNPH + I I+ ++ GG A +G+L+ ND +
Sbjct: 94 YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 151
Query: 77 MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
VN V + V H+ AV+ L+++G ++ +RR++ +
Sbjct: 152 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 187
Score = 51.2 bits (121), Expect = 9e-06
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 5/92 (5%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG N H G+ SI ++ ++ GG A+ G+LQ DR+ MVN S++ V H
Sbjct: 202 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 260
Query: 91 AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD 120
AV L+ + + + + + + + P PD
Sbjct: 261 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 292
Score = 46.6 bits (109), Expect = 2e-04
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAM 77
E V LH+ G G I GG D GE I +S +L GGPA+ G+LQ D++
Sbjct: 418 EPRKVVLHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 469
Query: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKI 104
VNG+ + H A L+ +G+ I
Sbjct: 470 VNGIDLRGASHEQAAAALKGAGQTVTI 496
Score = 42.0 bits (97), Expect = 0.005
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)
Query: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
R +G +AGG +D GIF+ ++ AA++G L D ILRVN VD + +
Sbjct: 103 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 162
Query: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
+AV L + G V + ++++ + +VE
Sbjct: 163 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 193
Score = 40.8 bits (94), Expect = 0.012
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)
Query: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468
IL +++ F+ +G +AGG D I+V +++ A K+G L+ GD++L
Sbjct: 187 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 246
Query: 469 RVNNVDFTNIIREEAVLFL 487
VNN + EEAV L
Sbjct: 247 MVNNYSLEEVTHEEAVAIL 265
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 133 bits (334), Expect = 2e-30
Identities = 128/476 (26%), Positives = 195/476 (40%), Gaps = 99/476 (20%)
Query: 405 DGVLPNSTHEDGILRPSMKL------------VKFRKGDS-VGLRLAGGND-VGIFVAGV 450
D +S H +PSM L V KG + +G + GG D GIFV+ +
Sbjct: 287 DDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFI 346
Query: 451 LEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRR 509
L PA G L+ GDQIL VN +D E+A L G+ VTI+AQ + + Y R
Sbjct: 347 LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPEDYAR 404
Query: 510 IVESDVGD-----------------------SFYIRTHFEYEKESP-----YGLSFNKGE 541
E+ + D S Y+R F+Y+K GLSF G+
Sbjct: 405 F-EAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 463
Query: 542 VFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ-----LASVQYTLPKTAGG 596
+ V++ + W A R+ E G+IP+K R E+ L +V++
Sbjct: 464 ILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVID 520
Query: 597 DRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADV 656
+ D + LR +EDL +YE V +E + RPV I GP+ D
Sbjct: 521 SKGDIPGLGDDGYGTKTLR-GQEDLIL--------SYEPVTRQEINYTRPVIILGPMKDR 571
Query: 657 AREKLAREEPDIY----QIAKSEPRDAGTDQRSSGII----------------------- 689
+ L E PD + RD D R +
Sbjct: 572 INDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYND 631
Query: 690 -----RLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLC 744
+ +++ + ++ KH +LDV+ NA+ RL AQ YPI +F+ P S + + M RL
Sbjct: 632 NLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLT 691
Query: 745 PESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
E A+K Y+R+ KL + FT + +++ D Y K I++Q +W+
Sbjct: 692 EE---QAKKTYDRAIKLEQEFGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 743
Score = 62.0 bits (149), Expect = 5e-09
Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)
Query: 19 WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76
+E +TL R G G +I+GG DNPH + I I+ ++ GG A +G+L+ ND +
Sbjct: 43 YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 100
Query: 77 MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
VN V + V H+ AV+ L+++G ++ +RR++ +
Sbjct: 101 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 136
Score = 59.7 bits (143), Expect = 2e-08
Identities = 61/249 (24%), Positives = 104/249 (41%), Gaps = 23/249 (9%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
G G +I+GG N H G+ SI ++ ++ GG A+ G+LQ DR+ MVN S++ V H
Sbjct: 151 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 209
Query: 91 AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD-----PEPV------SDNEEDSYDEEIH 137
AV L+ + + + + + + + P PD P+ +N Y +
Sbjct: 210 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLP 269
Query: 138 DPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSV--ASSQPAKPTKVTLVKSRKN 195
GR + + + D ++ + S + R ++ A S +P KV L K
Sbjct: 270 PISPGRYSPIPK--HMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG 327
Query: 196 EEY---GLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERS 252
+ G IFV I A G +Q GD +L +NG S A ++ +
Sbjct: 328 LGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387
Query: 253 KGKLKMVVQ 261
+ ++ Q
Sbjct: 388 GQTVTIIAQ 396
Score = 42.0 bits (97), Expect = 0.005
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)
Query: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
R +G +AGG +D GIF+ ++ AA++G L D ILRVN VD + +
Sbjct: 52 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 111
Query: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
+AV L + G V + ++++ + +VE
Sbjct: 112 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 142
Score = 40.8 bits (94), Expect = 0.012
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)
Query: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468
IL +++ F+ +G +AGG D I+V +++ A K+G L+ GD++L
Sbjct: 136 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195
Query: 469 RVNNVDFTNIIREEAVLFL 487
VNN + EEAV L
Sbjct: 196 MVNNYSLEEVTHEEAVAIL 214
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 128 bits (322), Expect = 4e-29
Identities = 122/489 (24%), Positives = 200/489 (40%), Gaps = 118/489 (24%)
Query: 411 STHEDGILRPSMKLVKFRKGDSVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQIL 468
S G R K++ + +G + GG D GIFV+ +L PA G L GD+IL
Sbjct: 37 SLRPGGDAREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRIL 96
Query: 469 RVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD----------- 517
VN V+ N E+A L G+ VTI+AQ + + Y R ES + D
Sbjct: 97 SVNGVNLRNATHEQAAAAL--KRAGQSVTIVAQYRPEEYSRF-ESKIHDLREQMMNSSMS 153
Query: 518 ------------SFYIRTHFEYEKE-----SPYGLSFNKGEVFRVVDTLYNGKLGSWLAI 560
S Y+R F+Y++ GLSF+ G++ V+ N W
Sbjct: 154 SGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVI----NASDDEWWQA 209
Query: 561 RIGKNHKEVER-GIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLR---- 615
R+ H E E+ G+IP+K R E+ + K F G+ S R+++
Sbjct: 210 RLVTPHGESEQIGVIPSKKRVEKKERARLKTVK--------FHARTGMIESNRSIKTKRK 261
Query: 616 ------------KSREDL--------------------SAQPVQTKFPAYERVVLREAGF 643
KS+E++ S++ + +YE V +E +
Sbjct: 262 KSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHY 321
Query: 644 LRPVTIFGPIADVAREKLAREEP----------------------DIYQIAKSEPR---- 677
RPV I GP+ D + L E P D + + E
Sbjct: 322 ARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDI 381
Query: 678 ------DAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPD 731
+AG + + +++ + ++ KH +LDV+ NA+ RL AQ YPI +F+ P
Sbjct: 382 QDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPK 441
Query: 732 SKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQ 791
S + + M R ++ + A K+Y+++ KL + FT + +S+ + Y +K+ I+
Sbjct: 442 SIEALMEMNRR---QTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEE-IYNKIKQIIE 497
Query: 792 QQQNQLVWV 800
Q +WV
Sbjct: 498 DQSGHYIWV 506
Score = 51.6 bits (122), Expect = 7e-06
Identities = 40/123 (32%), Positives = 60/123 (48%), Gaps = 26/123 (21%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAM 77
E + LH+ G G I GG D GE I +S +L GGPA+ G+L+ DR+
Sbjct: 46 EPRKIILHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELRRGDRILS 97
Query: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIH 137
VNGV++ N H A L+++G++ I V++ PE E ++ +IH
Sbjct: 98 VNGVNLRNATHEQAAAALKRAGQSVTI-----------VAQYRPE-----EYSRFESKIH 141
Query: 138 DPR 140
D R
Sbjct: 142 DLR 144
Score = 32.3 bits (72), Expect = 4.2
Identities = 33/126 (26%), Positives = 49/126 (38%), Gaps = 13/126 (10%)
Query: 141 SGRSGVVNRRSEKIWPR--DRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY 198
SG + + S W R R A RSL P D R +P K+ L K +
Sbjct: 10 SGLAMGLGSASASAWRRASQRWAWPLRSLRPGGDAR--------EPRKIILHKGSTGLGF 61
Query: 199 GL---RLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGK 255
+ IFV I A G ++ GD +L +NG N + A ++R+
Sbjct: 62 NIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS 121
Query: 256 LKMVVQ 261
+ +V Q
Sbjct: 122 VTIVAQ 127
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 98.2 bits (243), Expect = 6e-20
Identities = 84/325 (25%), Positives = 135/325 (41%), Gaps = 58/325 (17%)
Query: 518 SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERG 572
S Y+R F+Y+K GLSF G++ V++ + W A R+ E G
Sbjct: 20 SLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEEMG 76
Query: 573 IIPNKNRAEQ-----LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQ 627
+IP+K R E+ L +V++ + D + LR +EDL
Sbjct: 77 VIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLR-GQEDLIL---- 131
Query: 628 TKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEP----RDAGTDQ 683
+YE V +E + RPV I GP+ D + L E PD + RD D
Sbjct: 132 ----SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDG 187
Query: 684 RSSGII----------------------------RLHTIKQIIDQDKHALLDVTPNAVDR 715
R + + +++ + ++ KH +LDV+ NA+ R
Sbjct: 188 RDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKR 247
Query: 716 LNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINL 775
L AQ YPI +F+ P S + + M RL E A+K Y+R+ KL + FT +
Sbjct: 248 LQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE---QAKKTYDRAIKLEQEFGEYFTAIVQG 304
Query: 776 NSMNDGWYGALKEAIQQQQNQLVWV 800
+++ D Y K I++Q +W+
Sbjct: 305 DTLED-IYNQCKLVIEEQSGPFIWI 328
>gi|169160873 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 86.7 bits (213), Expect = 2e-16
Identities = 79/259 (30%), Positives = 114/259 (44%), Gaps = 51/259 (19%)
Query: 743 LCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSE 802
L P S +S R+LY ++ KLRK + HLFT TI LN +D WY K I++QQ + +W +E
Sbjct: 21 LAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTAE 80
Query: 803 GKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDY--------------EDTDT 848
K DG+ L D+ L+ ++ S DSR SDY T T
Sbjct: 81 DKLDGS------LEDNPHRGLADSSAD---LSCDSRVNSDYWRRRKARAARTLMASATQT 131
Query: 849 -EGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSS---------GMHHENQTYPPY 898
GG YTD + DE+ P A+ RSSEPV+ D H Q P+
Sbjct: 132 ASGGPYTDAD------DEL---PAPALDRSSEPVQADEPQSPRVRGRISAHQGPQVDSPH 182
Query: 899 SPQAQPQPIHRIDSP-GFKPASQQKAEASSPVPYLSPETNPASS--TSAVNHNVNL---- 951
+ Q R P K + +A SP+ + P + + A + +V L
Sbjct: 183 PQGQRRQDSMRTCEPEALKKKFTRVRDAESPMKMATTGVRPLTCDLSQAASWSVLLLPSW 242
Query: 952 --TNVRLEEPTPAPSTSYS 968
+V EPT +P +++S
Sbjct: 243 GWDSVSCTEPTTSPPSAWS 261
>gi|239747400 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 86.7 bits (213), Expect = 2e-16
Identities = 79/259 (30%), Positives = 114/259 (44%), Gaps = 51/259 (19%)
Query: 743 LCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSE 802
L P S +S R+LY ++ KLRK + HLFT TI LN +D WY K I++QQ + +W +E
Sbjct: 21 LAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTAE 80
Query: 803 GKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDY--------------EDTDT 848
K DG+ L D+ L+ ++ S DSR SDY T T
Sbjct: 81 DKLDGS------LEDNPHRGLADSSAD---LSCDSRVNSDYWRRRKARAARTLMASATQT 131
Query: 849 -EGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSS---------GMHHENQTYPPY 898
GG YTD + DE+ P A+ RSSEPV+ D H Q P+
Sbjct: 132 ASGGPYTDAD------DEL---PAPALDRSSEPVQADEPQSPRVRGRISAHQGPQVDSPH 182
Query: 899 SPQAQPQPIHRIDSP-GFKPASQQKAEASSPVPYLSPETNPASS--TSAVNHNVNL---- 951
+ Q R P K + +A SP+ + P + + A + +V L
Sbjct: 183 PQGQRRQDSMRTCEPEALKKKFTRVRDAESPMKMATTGVRPLTCDLSQAASWSVLLLPSW 242
Query: 952 --TNVRLEEPTPAPSTSYS 968
+V EPT +P +++S
Sbjct: 243 GWDSVSCTEPTTSPPSAWS 261
>gi|239741226 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 86.7 bits (213), Expect = 2e-16
Identities = 79/259 (30%), Positives = 114/259 (44%), Gaps = 51/259 (19%)
Query: 743 LCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSE 802
L P S +S R+LY ++ KLRK + HLFT TI LN +D WY K I++QQ + +W +E
Sbjct: 21 LAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTAE 80
Query: 803 GKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDY--------------EDTDT 848
K DG+ L D+ L+ ++ S DSR SDY T T
Sbjct: 81 DKLDGS------LEDNPHRGLADSSAD---LSCDSRVNSDYWRRRKARAARTLMASATQT 131
Query: 849 -EGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSS---------GMHHENQTYPPY 898
GG YTD + DE+ P A+ RSSEPV+ D H Q P+
Sbjct: 132 ASGGPYTDAD------DEL---PAPALDRSSEPVQADEPQSPRVRGRISAHQGPQVDSPH 182
Query: 899 SPQAQPQPIHRIDSP-GFKPASQQKAEASSPVPYLSPETNPASS--TSAVNHNVNL---- 951
+ Q R P K + +A SP+ + P + + A + +V L
Sbjct: 183 PQGQRRQDSMRTCEPEALKKKFTRVRDAESPMKMATTGVRPLTCDLSQAASWSVLLLPSW 242
Query: 952 --TNVRLEEPTPAPSTSYS 968
+V EPT +P +++S
Sbjct: 243 GWDSVSCTEPTTSPPSAWS 261
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 83.6 bits (205), Expect = 2e-15
Identities = 115/506 (22%), Positives = 209/506 (41%), Gaps = 71/506 (14%)
Query: 24 VTLHRAPGFGFGIAISGGRDN-PHFQSGET--SIVISDVLKGGPA--EGQLQENDRVAMV 78
V + R P GI+I GG+ ++GE I I VL+ PA L+ D++ V
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
Query: 79 NGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHD 138
+GV + N H+ AV+ ++ +G ++ P P+ ++ + +++ +
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSST--PRVIPNVHNKANKITGNQNQDTQE 1186
Query: 139 PRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDR---RSVASSQPAKPTKVTLVKSRKN 195
+ R G K+ P ++ + + + D + + P ++ +++ K+
Sbjct: 1187 KKEKRQGTAPPPM-KLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKD 1245
Query: 196 EE-YGLRLASH-------IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKT 247
+ GL LA + IFV I+ + AA DG ++ GD +L+IN + S +A
Sbjct: 1246 KNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
Query: 248 LIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRP 307
+I+ + K+K+V R+E A + + + S++ S +D S + ++S+ G
Sbjct: 1306 IIKTAPSKVKLVFIRNEDA-VNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDG-----S 1359
Query: 308 PRRSRSRSPDQRSEPSDHSRHSPQQ-PSNGSLRSRDEERISKPGAVSTPVKHADDHTPKT 366
+ P+ S S+ Q+ P+ S S++ P+ A +
Sbjct: 1360 VEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQE-----------IPLAPASSYHSTD 1408
Query: 367 VEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVK 426
+ G P+S P ++ I+ S K
Sbjct: 1409 AD----------------------FTGYGGFQAPLSVDPATCPIVPGQEMIIEIS----K 1442
Query: 427 FRKGDSVGLRLAGGNDV---GIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREE 482
R G +GL + GG D I + V E+ AA++G L GDQIL VN VD N EE
Sbjct: 1443 GRSG--LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEE 1500
Query: 483 AVLFLLDLPKGEEVTILAQKKKDVYR 508
A+ L P ++V ++ + + YR
Sbjct: 1501 AITALRQTP--QKVRLVVYRDEAHYR 1524
Score = 63.9 bits (154), Expect = 1e-09
Identities = 64/292 (21%), Positives = 123/292 (42%), Gaps = 54/292 (18%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAM 77
E H + L + G G++++G +D SI + + GPA +G+++ D +
Sbjct: 1236 ELHIIELEKDKN-GLGLSLAGNKDRSRM-----SIFVVGINPEGPAAADGRMRIGDELLE 1289
Query: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV---------QIPVSRPDP------- 121
+N + H A ++ + K+ R + +P S P
Sbjct: 1290 INNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGT 1349
Query: 122 EPVSDNEEDSYD---EEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSV-- 176
EP+S E+ S + +++ + S + V + +K + +S+E L+P S S
Sbjct: 1350 EPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDA 1409
Query: 177 ---------------ASSQPAKPTKVTLVKSRKNEEYGLRLA---------SHIFVKEIS 212
++ P P + +++ K GL L+ + I + E+
Sbjct: 1410 DFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRS-GLGLSIVGGKDTPLNAIVIHEVY 1468
Query: 213 QDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDE 264
++ AARDG + GD +L++NG N S +A T + ++ K+++VV RDE
Sbjct: 1469 EEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDE 1520
Score = 57.0 bits (136), Expect = 2e-07
Identities = 59/258 (22%), Positives = 103/258 (39%), Gaps = 73/258 (28%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
G G++I GG+D P +IVI +V + G A +G+L D++ VNGV + N H
Sbjct: 1446 GLGLSIVGGKDTPL-----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEE 1500
Query: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
A+ LR++ + ++ + R +E Y +E
Sbjct: 1501 AITALRQTPQKVRLVVYR-------------------DEAHYRDE--------------E 1527
Query: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKE 210
+ +I+P D R L +++V G R S +F+ +
Sbjct: 1528 NLEIFPVDLQKKAGRGLG------------------LSIV--------GKRNGSGVFISD 1561
Query: 211 ISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQR-------D 263
I + A DG + +GD +L +NG N S T+++ ++G +++ + R
Sbjct: 1562 IVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTS 1621
Query: 264 ERATLLNVPDLSDSIHSA 281
R T N S HS+
Sbjct: 1622 ARTTSQNSQGSQQSAHSS 1639
Score = 54.7 bits (130), Expect = 8e-07
Identities = 54/260 (20%), Positives = 106/260 (40%), Gaps = 18/260 (6%)
Query: 24 VTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGV 81
V L + G G G++I G R+ + + ISD++KGG A +G+L + D++ VNG
Sbjct: 1534 VDLQKKAGRGLGLSIVGKRNG-------SGVFISDIVKGGAADLDGRLIQGDQILSVNGE 1586
Query: 82 SMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRS 141
M N L+ + ++ I R + +R S N + S
Sbjct: 1587 DMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSAR----TTSQNSQGSQQSAHSSCHP 1642
Query: 142 GRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLR 201
+ V+ + + S +++ + R+V ++ + + G
Sbjct: 1643 SFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLG-- 1700
Query: 202 LASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGK--LKMV 259
+F+ I +AAR ++ GD ++ ING + +S D L++ + G+ L++V
Sbjct: 1701 -DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
Query: 260 VQRDERATLLNVPDLSDSIH 279
+ A + ++S H
Sbjct: 1760 ADTNISAIAAQLENMSTGYH 1779
Score = 50.4 bits (119), Expect = 1e-05
Identities = 69/316 (21%), Positives = 128/316 (40%), Gaps = 43/316 (13%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGT-VTENMSLTDAKTLIERSKGKLKMVVQRD- 263
IFVK++ S+A RD ++E D +L IN T + +N+S A L++++ G L+++V R+
Sbjct: 162 IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREP 221
Query: 264 -----ERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRS----RSR 314
++ LN L +++ + E + I++ L G R+
Sbjct: 222 VHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLA 281
Query: 315 SPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVER 374
D R + DH G + + + G + V R
Sbjct: 282 DRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG---------------NSVRMLVAR 326
Query: 375 NEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVG 434
+ S+ P P V P V SD L + +++LV+ + G S+G
Sbjct: 327 DPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETY--------NVELVR-KDGQSLG 377
Query: 435 LRLAG-------GNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLF 486
+R+ G G GI+V ++ S A G ++ D+I+ V+ V+ + V
Sbjct: 378 IRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEV 437
Query: 487 LLDLPKGEEVTILAQK 502
L + + +T++ +K
Sbjct: 438 LRNAGQVVHLTLVRRK 453
Score = 47.4 bits (111), Expect = 1e-04
Identities = 35/115 (30%), Positives = 58/115 (50%), Gaps = 8/115 (6%)
Query: 15 ETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETS-IVISDVLKGGPA--EGQLQE 71
+++++E + V L R G GI I G H +GE S I + ++ G A G +Q
Sbjct: 357 DSSLFETYNVELVRKDGQSLGIRIVGYVGTSH--TGEASGIYVKSIIPGSAAYHNGHIQV 414
Query: 72 NDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSD 126
ND++ V+GV++ + V+ LR +G+ +T+ R+K S EP SD
Sbjct: 415 NDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSS---STSPLEPPSD 466
Score = 42.4 bits (98), Expect = 0.004
Identities = 22/69 (31%), Positives = 34/69 (49%)
Query: 204 SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRD 263
S + V+ I LA RDG +Q GD +LKI GT + M+ ++ ++M+V RD
Sbjct: 268 SGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Query: 264 ERATLLNVP 272
+ P
Sbjct: 328 PAGDISVTP 336
Score = 41.2 bits (95), Expect = 0.009
Identities = 25/81 (30%), Positives = 42/81 (51%), Gaps = 5/81 (6%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEG--QLQENDRVAM 77
E TV ++R GI+I+GGR +P G+ + I+ + G A +L+ DR+
Sbjct: 1673 EPRTVEINRELSDALGISIAGGRGSP---LGDIPVFIAMIQASGVAARTQKLKVGDRIVS 1729
Query: 78 VNGVSMDNVEHAFAVQQLRKS 98
+NG +D + HA V L+ +
Sbjct: 1730 INGQPLDGLSHADVVNLLKNA 1750
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 82.0 bits (201), Expect = 5e-15
Identities = 105/516 (20%), Positives = 211/516 (40%), Gaps = 81/516 (15%)
Query: 338 LRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDV 397
L S ++ + V PV H K +E+T N TP + + +V + ++
Sbjct: 182 LISNAQDLAQEVQTVLKPVHH------KEGQELTALLN---TPHIQALLLAHDKVAEQEM 232
Query: 398 DLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDV-GIFVAGVLEDSPA 456
L + V + G ++K+V+ K + L N++ + ++ +++ A
Sbjct: 233 QLEPITDERVYESIGQYGG---ETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAA 289
Query: 457 AKEGL-EEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDV 515
K GL EGD++L +N ++ E L D+ G +L ++ E+ +
Sbjct: 290 EKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDM-HGTLTFVLIPSQQIKPPPAKETVI 348
Query: 516 GDSFYIRTHFEYE-KESPY------GLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKE 568
+++ HF+Y+ + PY GLSF KG++ V+ W A R G +
Sbjct: 349 ----HVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVIS---QEDPNWWQAYREGDEDNQ 401
Query: 569 VERGIIPNKNRAEQLASVQYTLPKTAGGDRA-DFWRFRGLRSSKRNL---RKSREDLSAQ 624
G++P K+ +Q +++ T+ + +++ W + + ++ + +D +
Sbjct: 402 PLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNE 461
Query: 625 PVQTKFPAYERVVL--REAGFLRPVTIFGPI---ADVAREKLAREEPDIYQIAKSEPRDA 679
+ T YE + L + A RP+ + GP + R++L +E D + A +
Sbjct: 462 EILT----YEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRS 517
Query: 680 GTDQRSSGI-------------------------------IRLHTIKQIIDQDKHALLDV 708
DQ +G + +++Q+I+ K LL +
Sbjct: 518 RRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSL 577
Query: 709 TPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESR----KSARKLYERSHKLRKN 764
++ L + P ++F+ P S++ +R L E + + R++ E++ ++ +N
Sbjct: 578 RTQSLKTLRNSDLKPYIIFIAPPSQE---RLRALLAKEGKNPKPEELREIIEKTREMEQN 634
Query: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
N H F T I +NS D Y L I + + WV
Sbjct: 635 NGHYFDTAI-VNSDLDKAYQELLRLINKLDTEPQWV 669
Score = 36.6 bits (83), Expect = 0.22
Identities = 27/108 (25%), Positives = 43/108 (39%), Gaps = 5/108 (4%)
Query: 158 DRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLA-----SHIFVKEIS 212
D+ A +E L P +D R S V +V+ K + L + + I
Sbjct: 225 DKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIV 284
Query: 213 QDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVV 260
+ A + G + EGD VL+ING + + L+ G L V+
Sbjct: 285 KGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVL 332
Score = 32.0 bits (71), Expect = 5.4
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Query: 53 SIVISDVLKGGPAE--GQLQENDRVAMVNGVSM 83
S++IS ++KGG AE G L E D V +NG+ +
Sbjct: 277 SVIISRIVKGGAAEKSGLLHEGDEVLEINGIEI 309
>gi|16933525 unc5C [Homo sapiens]
Length = 931
Score = 78.6 bits (192), Expect = 5e-14
Identities = 45/95 (47%), Positives = 58/95 (61%), Gaps = 3/95 (3%)
Query: 1635 TARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLL 1694
TA G FNS GG L +GVS++IP GAIP+G E+Y V R ++ PP+D +TLL
Sbjct: 531 TAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMD--DSQTLL 588
Query: 1695 SPLVMCGPHGLKFLKPVELRLPHC-DPKTWQNKCL 1728
+P+V CGP G +PV L + HC DP T K L
Sbjct: 589 TPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKIL 623
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 78.6 bits (192), Expect = 5e-14
Identities = 121/519 (23%), Positives = 215/519 (41%), Gaps = 109/519 (21%)
Query: 35 GIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAFAV 92
GI+++GG + G I + V+ G AE G++ + DRV VNGVS++ H AV
Sbjct: 1188 GISVTGGVNTSVRHGG---IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAV 1244
Query: 93 QQLRKSGKNAKITIRR----KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGR--SGV 146
+ LR +G+ + + + K +PV+ P N + E++ + S V
Sbjct: 1245 ETLRNTGQVVHLLLEKGQSPTSKEHVPVT-PQCTLSDQNAQGQGPEKVKKTTQVKDYSFV 1303
Query: 147 VNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHI 206
+ ++ S+ S S R D L+ + N AS +
Sbjct: 1304 TEENTFEVKLFKNSSGLGFSFS-RED---------------NLIPEQIN-------ASIV 1340
Query: 207 FVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERA 266
VK++ AA G I GDV+LK+NG + +S + + + + ++ +++ R
Sbjct: 1341 RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG 1400
Query: 267 TLLNVPDLSDSIHSANASERDDISEIQSLAS--DHSGRSHDRPPRRSRSRSPDQRSEPSD 324
L P++ ++ ++ +QS A +S + +P +S S D+ +E SD
Sbjct: 1401 VL---PEIDTAL----------LTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDE-NEMSD 1446
Query: 325 HSRHSPQQPS-----NGSLRSRDEERISKPGAVSTP-------------VKHADDH--TP 364
S+ + PS + S S +++ ++ P +S V A H P
Sbjct: 1447 KSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAP 1506
Query: 365 KTVEEV--TVERNEKQTPSLPE-----PKPVYAQVGQPDVDLPVSPS-DGVLPNSTHEDG 416
K+ E+ T+ ++ P+ PE P P+ + P S S + H
Sbjct: 1507 KSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHH 1566
Query: 417 ILRPS--------------------------MKLVKFRKGDSVGLRLAGGND-VGIFVAG 449
I P+ + L+K KG S+G + GN +G +V
Sbjct: 1567 ISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKG-SLGFTVTKGNQRIGCYVHD 1625
Query: 450 VLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFL 487
V++D PA +G L+ GD++++VN+ D TN+ +AV L
Sbjct: 1626 VIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLL 1663
Score = 56.2 bits (134), Expect = 3e-07
Identities = 85/361 (23%), Positives = 140/361 (38%), Gaps = 58/361 (16%)
Query: 24 VTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGV 81
V L + +G G I GG G I IS V GGPA+ G L+ DR+ VN V
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLG---IFISSVAPGGPADLDGCLKPGDRLISVNSV 959
Query: 82 SMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS-DNEEDSYDEEIHDPR 140
S++ V H A++ L+ + ++ + I + K+ +S+ PV NE +Y ++ +
Sbjct: 960 SLEGVSHHAAIEILQNAPEDVTLVISQPKE---KISKVPSTPVHLTNEMKNYMKKSSYMQ 1016
Query: 141 SGRSGVVNRRSEKIWPRDRSAS-RERSLSPRSD-RRSVASSQPAKPTKVTLVKSRKNEEY 198
S + + + W R E S P R SSQ ++ +L +S+ N +
Sbjct: 1017 D--SAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFF 1074
Query: 199 GLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKM 258
L + Q+S Q G + TE + TD+ +SK K
Sbjct: 1075 ASHLGDQTW-----QES--------QHGSPSPSVISKATEKETFTDS----NQSKTK--- 1114
Query: 259 VVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQ 318
+ + +V D SD S+ D+ A+ S + H P + S S
Sbjct: 1115 ------KPGISDVTDYSD----RGDSDMDE-------ATYSSSQDHQTP--KQESSSSVN 1155
Query: 319 RSEPSDHSRHSPQQPSNGSL------RSRDEERISKPGAVSTPVKHADDHTPKTVEEVTV 372
S + S P G + ++ + IS G V+T V+H + + +
Sbjct: 1156 TSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAA 1215
Query: 373 E 373
E
Sbjct: 1216 E 1216
Score = 42.7 bits (99), Expect = 0.003
Identities = 29/100 (29%), Positives = 52/100 (52%), Gaps = 10/100 (10%)
Query: 424 LVKFRKGDSVGL--RLAGGN-----DVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDF 475
LV +K GL ++ GG D+GIF++ V PA +G L+ GD+++ VN+V
Sbjct: 902 LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 961
Query: 476 TNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDV 515
+ A+ L + P E+VT++ + K+ ++ + V
Sbjct: 962 EGVSHHAAIEILQNAP--EDVTLVISQPKEKISKVPSTPV 999
Score = 40.0 bits (92), Expect = 0.020
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 7/81 (8%)
Query: 187 VTLVKSRKNEEYGLRLASH-----IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS 241
+TL+KS K G + +V ++ QD A DG ++ GD ++K+N T NM+
Sbjct: 1598 ITLIKSEKGS-LGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMT 1655
Query: 242 LTDAKTLIERSKGKLKMVVQR 262
TDA L+ + +++V+ R
Sbjct: 1656 HTDAVNLLRAASKTVRLVIGR 1676
Score = 38.5 bits (88), Expect = 0.058
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
+++ +I+ S+AA +GN+Q DV+ +NG T+ M+L + ++ S L +V + R
Sbjct: 1717 VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS---LPSLVLKATR 1773
Query: 266 ATLLNVPDLSDSIHSANASER 286
L VP S SA S +
Sbjct: 1774 NDLPVVPSSKRSAVSAPKSTK 1794
Score = 35.4 bits (80), Expect = 0.49
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 10/100 (10%)
Query: 178 SSQPAKPTKVTLVKSRKNEE-YGLRLASH---------IFVKEISQDSLAARDGNIQEGD 227
SS P KP + V+ KN+ G+ + I+VK + A DG I +GD
Sbjct: 1166 SSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGD 1225
Query: 228 VVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERAT 267
VL +NG E + A + + + +++++ + T
Sbjct: 1226 RVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPT 1265
Score = 34.7 bits (78), Expect = 0.84
Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 7/79 (8%)
Query: 55 VISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV-- 112
VI D K ++G+L+ DR+ VN + N+ H AV LR + K ++ I R ++
Sbjct: 1626 VIQDPAK---SDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPR 1682
Query: 113 --QIPVSRPDPEPVSDNEE 129
+P PD + EE
Sbjct: 1683 IPMLPHLLPDITLTCNKEE 1701
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 78.6 bits (192), Expect = 5e-14
Identities = 121/519 (23%), Positives = 215/519 (41%), Gaps = 109/519 (21%)
Query: 35 GIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAFAV 92
GI+++GG + G I + V+ G AE G++ + DRV VNGVS++ H AV
Sbjct: 1379 GISVTGGVNTSVRHGG---IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAV 1435
Query: 93 QQLRKSGKNAKITIRR----KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGR--SGV 146
+ LR +G+ + + + K +PV+ P N + E++ + S V
Sbjct: 1436 ETLRNTGQVVHLLLEKGQSPTSKEHVPVT-PQCTLSDQNAQGQGPEKVKKTTQVKDYSFV 1494
Query: 147 VNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHI 206
+ ++ S+ S S R D L+ + N AS +
Sbjct: 1495 TEENTFEVKLFKNSSGLGFSFS-RED---------------NLIPEQIN-------ASIV 1531
Query: 207 FVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERA 266
VK++ AA G I GDV+LK+NG + +S + + + + ++ +++ R
Sbjct: 1532 RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG 1591
Query: 267 TLLNVPDLSDSIHSANASERDDISEIQSLAS--DHSGRSHDRPPRRSRSRSPDQRSEPSD 324
L P++ ++ ++ +QS A +S + +P +S S D+ +E SD
Sbjct: 1592 VL---PEIDTAL----------LTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDE-NEMSD 1637
Query: 325 HSRHSPQQPS-----NGSLRSRDEERISKPGAVSTP-------------VKHADDH--TP 364
S+ + PS + S S +++ ++ P +S V A H P
Sbjct: 1638 KSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAP 1697
Query: 365 KTVEEV--TVERNEKQTPSLPE-----PKPVYAQVGQPDVDLPVSPS-DGVLPNSTHEDG 416
K+ E+ T+ ++ P+ PE P P+ + P S S + H
Sbjct: 1698 KSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHH 1757
Query: 417 ILRPS--------------------------MKLVKFRKGDSVGLRLAGGND-VGIFVAG 449
I P+ + L+K KG S+G + GN +G +V
Sbjct: 1758 ISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKG-SLGFTVTKGNQRIGCYVHD 1816
Query: 450 VLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFL 487
V++D PA +G L+ GD++++VN+ D TN+ +AV L
Sbjct: 1817 VIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLL 1854
Score = 56.2 bits (134), Expect = 3e-07
Identities = 85/361 (23%), Positives = 140/361 (38%), Gaps = 58/361 (16%)
Query: 24 VTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGV 81
V L + +G G I GG G I IS V GGPA+ G L+ DR+ VN V
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLG---IFISSVAPGGPADLDGCLKPGDRLISVNSV 1150
Query: 82 SMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS-DNEEDSYDEEIHDPR 140
S++ V H A++ L+ + ++ + I + K+ +S+ PV NE +Y ++ +
Sbjct: 1151 SLEGVSHHAAIEILQNAPEDVTLVISQPKE---KISKVPSTPVHLTNEMKNYMKKSSYMQ 1207
Query: 141 SGRSGVVNRRSEKIWPRDRSAS-RERSLSPRSD-RRSVASSQPAKPTKVTLVKSRKNEEY 198
S + + + W R E S P R SSQ ++ +L +S+ N +
Sbjct: 1208 D--SAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFF 1265
Query: 199 GLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKM 258
L + Q+S Q G + TE + TD+ +SK K
Sbjct: 1266 ASHLGDQTW-----QES--------QHGSPSPSVISKATEKETFTDS----NQSKTK--- 1305
Query: 259 VVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQ 318
+ + +V D SD S+ D+ A+ S + H P + S S
Sbjct: 1306 ------KPGISDVTDYSD----RGDSDMDE-------ATYSSSQDHQTP--KQESSSSVN 1346
Query: 319 RSEPSDHSRHSPQQPSNGSL------RSRDEERISKPGAVSTPVKHADDHTPKTVEEVTV 372
S + S P G + ++ + IS G V+T V+H + + +
Sbjct: 1347 TSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAA 1406
Query: 373 E 373
E
Sbjct: 1407 E 1407
Score = 43.5 bits (101), Expect = 0.002
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 17/156 (10%)
Query: 374 RNEKQTPSLPEPKPVYA------QVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKF 427
++E + S+ +P Y G +P+ +D VL + LV
Sbjct: 1038 KHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKEND-VLHKRWSIVSSPEREITLVNL 1096
Query: 428 RKGDSVGL--RLAGGN-----DVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
+K GL ++ GG D+GIF++ V PA +G L+ GD+++ VN+V +
Sbjct: 1097 KKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVS 1156
Query: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDV 515
A+ L + P E+VT++ + K+ ++ + V
Sbjct: 1157 HHAAIEILQNAP--EDVTLVISQPKEKISKVPSTPV 1190
Score = 40.0 bits (92), Expect = 0.020
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 7/81 (8%)
Query: 187 VTLVKSRKNEEYGLRLASH-----IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS 241
+TL+KS K G + +V ++ QD A DG ++ GD ++K+N T NM+
Sbjct: 1789 ITLIKSEKGS-LGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMT 1846
Query: 242 LTDAKTLIERSKGKLKMVVQR 262
TDA L+ + +++V+ R
Sbjct: 1847 HTDAVNLLRAASKTVRLVIGR 1867
Score = 38.5 bits (88), Expect = 0.058
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
+++ +I+ S+AA +GN+Q DV+ +NG T+ M+L + ++ S L +V + R
Sbjct: 1908 VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS---LPSLVLKATR 1964
Query: 266 ATLLNVPDLSDSIHSANASER 286
L VP S SA S +
Sbjct: 1965 NDLPVVPSSKRSAVSAPKSTK 1985
Score = 35.4 bits (80), Expect = 0.49
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 10/100 (10%)
Query: 178 SSQPAKPTKVTLVKSRKNEE-YGLRLASH---------IFVKEISQDSLAARDGNIQEGD 227
SS P KP + V+ KN+ G+ + I+VK + A DG I +GD
Sbjct: 1357 SSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGD 1416
Query: 228 VVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERAT 267
VL +NG E + A + + + +++++ + T
Sbjct: 1417 RVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPT 1456
Score = 34.7 bits (78), Expect = 0.84
Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 7/79 (8%)
Query: 55 VISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV-- 112
VI D K ++G+L+ DR+ VN + N+ H AV LR + K ++ I R ++
Sbjct: 1817 VIQDPAK---SDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPR 1873
Query: 113 --QIPVSRPDPEPVSDNEE 129
+P PD + EE
Sbjct: 1874 IPMLPHLLPDITLTCNKEE 1892
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 78.6 bits (192), Expect = 5e-14
Identities = 121/519 (23%), Positives = 215/519 (41%), Gaps = 109/519 (21%)
Query: 35 GIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAFAV 92
GI+++GG + G I + V+ G AE G++ + DRV VNGVS++ H AV
Sbjct: 1360 GISVTGGVNTSVRHGG---IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAV 1416
Query: 93 QQLRKSGKNAKITIRR----KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGR--SGV 146
+ LR +G+ + + + K +PV+ P N + E++ + S V
Sbjct: 1417 ETLRNTGQVVHLLLEKGQSPTSKEHVPVT-PQCTLSDQNAQGQGPEKVKKTTQVKDYSFV 1475
Query: 147 VNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHI 206
+ ++ S+ S S R D L+ + N AS +
Sbjct: 1476 TEENTFEVKLFKNSSGLGFSFS-RED---------------NLIPEQIN-------ASIV 1512
Query: 207 FVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERA 266
VK++ AA G I GDV+LK+NG + +S + + + + ++ +++ R
Sbjct: 1513 RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG 1572
Query: 267 TLLNVPDLSDSIHSANASERDDISEIQSLAS--DHSGRSHDRPPRRSRSRSPDQRSEPSD 324
L P++ ++ ++ +QS A +S + +P +S S D+ +E SD
Sbjct: 1573 VL---PEIDTAL----------LTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDE-NEMSD 1618
Query: 325 HSRHSPQQPS-----NGSLRSRDEERISKPGAVSTP-------------VKHADDH--TP 364
S+ + PS + S S +++ ++ P +S V A H P
Sbjct: 1619 KSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAP 1678
Query: 365 KTVEEV--TVERNEKQTPSLPE-----PKPVYAQVGQPDVDLPVSPS-DGVLPNSTHEDG 416
K+ E+ T+ ++ P+ PE P P+ + P S S + H
Sbjct: 1679 KSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHH 1738
Query: 417 ILRPS--------------------------MKLVKFRKGDSVGLRLAGGND-VGIFVAG 449
I P+ + L+K KG S+G + GN +G +V
Sbjct: 1739 ISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKG-SLGFTVTKGNQRIGCYVHD 1797
Query: 450 VLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFL 487
V++D PA +G L+ GD++++VN+ D TN+ +AV L
Sbjct: 1798 VIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLL 1835
Score = 56.2 bits (134), Expect = 3e-07
Identities = 85/361 (23%), Positives = 140/361 (38%), Gaps = 58/361 (16%)
Query: 24 VTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGV 81
V L + +G G I GG G I IS V GGPA+ G L+ DR+ VN V
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLG---IFISSVAPGGPADLDGCLKPGDRLISVNSV 1131
Query: 82 SMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS-DNEEDSYDEEIHDPR 140
S++ V H A++ L+ + ++ + I + K+ +S+ PV NE +Y ++ +
Sbjct: 1132 SLEGVSHHAAIEILQNAPEDVTLVISQPKE---KISKVPSTPVHLTNEMKNYMKKSSYMQ 1188
Query: 141 SGRSGVVNRRSEKIWPRDRSAS-RERSLSPRSD-RRSVASSQPAKPTKVTLVKSRKNEEY 198
S + + + W R E S P R SSQ ++ +L +S+ N +
Sbjct: 1189 D--SAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFF 1246
Query: 199 GLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKM 258
L + Q+S Q G + TE + TD+ +SK K
Sbjct: 1247 ASHLGDQTW-----QES--------QHGSPSPSVISKATEKETFTDS----NQSKTK--- 1286
Query: 259 VVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQ 318
+ + +V D SD S+ D+ A+ S + H P + S S
Sbjct: 1287 ------KPGISDVTDYSD----RGDSDMDE-------ATYSSSQDHQTP--KQESSSSVN 1327
Query: 319 RSEPSDHSRHSPQQPSNGSL------RSRDEERISKPGAVSTPVKHADDHTPKTVEEVTV 372
S + S P G + ++ + IS G V+T V+H + + +
Sbjct: 1328 TSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAA 1387
Query: 373 E 373
E
Sbjct: 1388 E 1388
Score = 42.7 bits (99), Expect = 0.003
Identities = 29/100 (29%), Positives = 52/100 (52%), Gaps = 10/100 (10%)
Query: 424 LVKFRKGDSVGL--RLAGGN-----DVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDF 475
LV +K GL ++ GG D+GIF++ V PA +G L+ GD+++ VN+V
Sbjct: 1074 LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1133
Query: 476 TNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDV 515
+ A+ L + P E+VT++ + K+ ++ + V
Sbjct: 1134 EGVSHHAAIEILQNAP--EDVTLVISQPKEKISKVPSTPV 1171
Score = 40.0 bits (92), Expect = 0.020
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 7/81 (8%)
Query: 187 VTLVKSRKNEEYGLRLASH-----IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS 241
+TL+KS K G + +V ++ QD A DG ++ GD ++K+N T NM+
Sbjct: 1770 ITLIKSEKGS-LGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMT 1827
Query: 242 LTDAKTLIERSKGKLKMVVQR 262
TDA L+ + +++V+ R
Sbjct: 1828 HTDAVNLLRAASKTVRLVIGR 1848
Score = 38.5 bits (88), Expect = 0.058
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
+++ +I+ S+AA +GN+Q DV+ +NG T+ M+L + ++ S L +V + R
Sbjct: 1889 VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS---LPSLVLKATR 1945
Query: 266 ATLLNVPDLSDSIHSANASER 286
L VP S SA S +
Sbjct: 1946 NDLPVVPSSKRSAVSAPKSTK 1966
Score = 35.4 bits (80), Expect = 0.49
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 10/100 (10%)
Query: 178 SSQPAKPTKVTLVKSRKNEE-YGLRLASH---------IFVKEISQDSLAARDGNIQEGD 227
SS P KP + V+ KN+ G+ + I+VK + A DG I +GD
Sbjct: 1338 SSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGD 1397
Query: 228 VVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERAT 267
VL +NG E + A + + + +++++ + T
Sbjct: 1398 RVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPT 1437
Score = 34.7 bits (78), Expect = 0.84
Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 7/79 (8%)
Query: 55 VISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV-- 112
VI D K ++G+L+ DR+ VN + N+ H AV LR + K ++ I R ++
Sbjct: 1798 VIQDPAK---SDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPR 1854
Query: 113 --QIPVSRPDPEPVSDNEE 129
+P PD + EE
Sbjct: 1855 IPMLPHLLPDITLTCNKEE 1873
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 77.0 bits (188), Expect = 1e-13
Identities = 121/525 (23%), Positives = 210/525 (40%), Gaps = 107/525 (20%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA-EGQLQENDRVAMV 78
E+ T+T+ R G G GI+I+GG+ + ++ + I IS V + GPA ++ D++ V
Sbjct: 725 EELTLTILRQTG-GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEV 783
Query: 79 NGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHD 138
NGV++ EH AV+ LR +G ++ + R++ V+ P + P+ ED Y
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVE-PENAVTITPL--RPEDDY-----S 835
Query: 139 PRSGRSGVVNRRSEKIWPRDRSASRERSLS--PRSDRR---SVASSQPAKPTKVTLVKSR 193
PR R G R + P R+R ++ RS+R S+A + + P +
Sbjct: 836 PRERRGG--GLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAG----- 888
Query: 194 KNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSK 253
+ IFV I++ A R G +Q GD VL ING A +L+ +
Sbjct: 889 ---------DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAAS 939
Query: 254 GKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRS 313
+ ++++R+ L P H PP + +
Sbjct: 940 PTIALLLEREAGGPLPPSP-----------------------------LPHSSPPTAAVA 970
Query: 314 RSPDQRSEPSDHSRHS--PQQPSNGSLRSRDEERISKP---GAVSTPVKHADDHT--PKT 366
+ + P S P + E I P G + + DH+ P
Sbjct: 971 TTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFG 1030
Query: 367 VEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGI---LRPSMK 423
V+E V S P+ + A+ G D ++ + + ++TH++ + LRP ++
Sbjct: 1031 VQEPGV------FISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLE 1084
Query: 424 L-----------------VKFRKGDSVGLRLAGG-----------NDVGIFVAGVLEDSP 455
L ++ G+ +G+ + GG D GIF++ V
Sbjct: 1085 LSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGA 1144
Query: 456 AAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTIL 499
A ++G L G ++L VN + EAV L + G+ +T+L
Sbjct: 1145 AGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVL 1187
Score = 50.4 bits (119), Expect = 1e-05
Identities = 41/165 (24%), Positives = 70/165 (42%), Gaps = 25/165 (15%)
Query: 328 HSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKP 387
H+P P R++ EE + G+ + ++ EE + E +K+ + P
Sbjct: 650 HAPWAP-----RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSV 704
Query: 388 VYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGG------- 440
Q + +L + P+ I + L R+ +G+ +AGG
Sbjct: 705 KGVSFDQAN-NLLIEPAR-----------IEEEELTLTILRQTGGLGISIAGGKGSTPYK 752
Query: 441 -NDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAV 484
+D GIF++ V E+ PAA+ G+ GD++L VN V EAV
Sbjct: 753 GDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAV 797
Score = 40.8 bits (94), Expect = 0.012
Identities = 82/389 (21%), Positives = 135/389 (34%), Gaps = 81/389 (20%)
Query: 24 VTLHRAPGFGFGIAISGGRDNPHFQSG--ETSIVISDVL-KGGPAEGQLQENDRVAMVNG 80
+ L RA G G++I GG D+ G E + IS VL +G A L+ DR+ VNG
Sbjct: 1005 IRLPRAGG-PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNG 1063
Query: 81 VSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPR 140
+ + H AV L + + +RR DP P P
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRR-----------DPAP---------------PG 1097
Query: 141 SGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGL 200
+ E++ R +R + +PR PT
Sbjct: 1098 LRELCIQKAPGERLGISIRGGARGHAGNPRD------------PTD-------------- 1131
Query: 201 RLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVV 260
IF+ ++S A RDG ++ G +L++N ++ +A L+ L ++V
Sbjct: 1132 ---EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Query: 261 ----QRDERATLLNVPDLSDSIHSANASERDDISEIQS----LASDHSGRSHDRPPR--- 309
+ A L P + + +A R+ + I S L+ + G+ + P +
Sbjct: 1189 CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLH 1248
Query: 310 --------RSRSRSP---DQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKH 358
R P D R+ + S S Q+ +G+ + E P P
Sbjct: 1249 WGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPP 1308
Query: 359 ADDHTPKTVEEVTVERNEKQTPSLPEPKP 387
+ D P V++ T PE P
Sbjct: 1309 SPDELPANVKQAYRAFAAVPTSHPPEDAP 1337
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 77.0 bits (188), Expect = 1e-13
Identities = 121/525 (23%), Positives = 210/525 (40%), Gaps = 107/525 (20%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA-EGQLQENDRVAMV 78
E+ T+T+ R G G GI+I+GG+ + ++ + I IS V + GPA ++ D++ V
Sbjct: 725 EELTLTILRQTG-GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEV 783
Query: 79 NGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHD 138
NGV++ EH AV+ LR +G ++ + R++ V+ P + P+ ED Y
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVE-PENAVTITPL--RPEDDY-----S 835
Query: 139 PRSGRSGVVNRRSEKIWPRDRSASRERSLS--PRSDRR---SVASSQPAKPTKVTLVKSR 193
PR R G R + P R+R ++ RS+R S+A + + P +
Sbjct: 836 PRERRGG--GLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAG----- 888
Query: 194 KNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSK 253
+ IFV I++ A R G +Q GD VL ING A +L+ +
Sbjct: 889 ---------DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAAS 939
Query: 254 GKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRS 313
+ ++++R+ L P H PP + +
Sbjct: 940 PTIALLLEREAGGPLPPSP-----------------------------LPHSSPPTAAVA 970
Query: 314 RSPDQRSEPSDHSRHS--PQQPSNGSLRSRDEERISKP---GAVSTPVKHADDHT--PKT 366
+ + P S P + E I P G + + DH+ P
Sbjct: 971 TTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFG 1030
Query: 367 VEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGI---LRPSMK 423
V+E V S P+ + A+ G D ++ + + ++TH++ + LRP ++
Sbjct: 1031 VQEPGV------FISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLE 1084
Query: 424 L-----------------VKFRKGDSVGLRLAGG-----------NDVGIFVAGVLEDSP 455
L ++ G+ +G+ + GG D GIF++ V
Sbjct: 1085 LSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGA 1144
Query: 456 AAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTIL 499
A ++G L G ++L VN + EAV L + G+ +T+L
Sbjct: 1145 AGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVL 1187
Score = 50.4 bits (119), Expect = 1e-05
Identities = 41/165 (24%), Positives = 70/165 (42%), Gaps = 25/165 (15%)
Query: 328 HSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKP 387
H+P P R++ EE + G+ + ++ EE + E +K+ + P
Sbjct: 650 HAPWAP-----RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSV 704
Query: 388 VYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGG------- 440
Q + +L + P+ I + L R+ +G+ +AGG
Sbjct: 705 KGVSFDQAN-NLLIEPAR-----------IEEEELTLTILRQTGGLGISIAGGKGSTPYK 752
Query: 441 -NDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAV 484
+D GIF++ V E+ PAA+ G+ GD++L VN V EAV
Sbjct: 753 GDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAV 797
Score = 40.8 bits (94), Expect = 0.012
Identities = 82/389 (21%), Positives = 135/389 (34%), Gaps = 81/389 (20%)
Query: 24 VTLHRAPGFGFGIAISGGRDNPHFQSG--ETSIVISDVL-KGGPAEGQLQENDRVAMVNG 80
+ L RA G G++I GG D+ G E + IS VL +G A L+ DR+ VNG
Sbjct: 1005 IRLPRAGG-PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNG 1063
Query: 81 VSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPR 140
+ + H AV L + + +RR DP P P
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRR-----------DPAP---------------PG 1097
Query: 141 SGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGL 200
+ E++ R +R + +PR PT
Sbjct: 1098 LRELCIQKAPGERLGISIRGGARGHAGNPRD------------PTD-------------- 1131
Query: 201 RLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVV 260
IF+ ++S A RDG ++ G +L++N ++ +A L+ L ++V
Sbjct: 1132 ---EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Query: 261 ----QRDERATLLNVPDLSDSIHSANASERDDISEIQS----LASDHSGRSHDRPPR--- 309
+ A L P + + +A R+ + I S L+ + G+ + P +
Sbjct: 1189 CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLH 1248
Query: 310 --------RSRSRSP---DQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKH 358
R P D R+ + S S Q+ +G+ + E P P
Sbjct: 1249 WGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPP 1308
Query: 359 ADDHTPKTVEEVTVERNEKQTPSLPEPKP 387
+ D P V++ T PE P
Sbjct: 1309 SPDELPANVKQAYRAFAAVPTSHPPEDAP 1337
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 74.7 bits (182), Expect = 7e-13
Identities = 116/500 (23%), Positives = 207/500 (41%), Gaps = 106/500 (21%)
Query: 54 IVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKK- 110
I + V+ G AE G++ + DRV VNGVS++ H AV+ LR +G+ + + + +
Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQS 1459
Query: 111 ---KVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGR--SGVVNRRSEKIWPRDRSASRER 165
K +PV+ P N + E++ + S V + ++ S+
Sbjct: 1460 PTSKEHVPVT-PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGF 1518
Query: 166 SLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQE 225
S S R D L+ + N AS + VK++ AA G I
Sbjct: 1519 SFS-REDN---------------LIPEQIN-------ASIVRVKKLFPGQPAAESGKIDV 1555
Query: 226 GDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASE 285
GDV+LK+NG + +S + + + + ++ +++ R L P++ ++
Sbjct: 1556 GDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVL---PEIDTAL------- 1605
Query: 286 RDDISEIQSLAS--DHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPS-----NGSL 338
++ +QS A +S + +P +S S D+ +E SD S+ + PS + S
Sbjct: 1606 ---LTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDE-NEMSDKSKKQCKSPSRRDSYSDSS 1661
Query: 339 RSRDEERISKPGAVSTP-------------VKHADDH--TPKTVEEV--TVERNEKQTPS 381
S +++ ++ P +S V A H PK+ E+ T+ ++ P+
Sbjct: 1662 GSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPN 1721
Query: 382 LPE-----PKPVYAQVGQPDVDLPVSPS-DGVLPNSTHEDGILRPSMK------------ 423
PE P P+ + P S S + H I P+ +
Sbjct: 1722 KPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLEN 1781
Query: 424 --------------LVKFRKGDSVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQI 467
L+K KG S+G + GN +G +V V++D PA +G L+ GD++
Sbjct: 1782 HLEDFELEVELLITLIKSEKG-SLGFTVTKGNQRIGCYVHDVIQD-PAKSDGRLKPGDRL 1839
Query: 468 LRVNNVDFTNIIREEAVLFL 487
++VN+ D TN+ +AV L
Sbjct: 1840 IKVNDTDVTNMTHTDAVNLL 1859
Score = 52.8 bits (125), Expect = 3e-06
Identities = 97/491 (19%), Positives = 182/491 (37%), Gaps = 38/491 (7%)
Query: 24 VTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGV 81
V L + +G G I GG G I IS V GGPA+ G L+ DR+ VN V
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLG---IFISSVAPGGPADLDGCLKPGDRLISVNSV 1150
Query: 82 SMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS-DNEEDSYDEEIHDPR 140
S++ V H A++ L+ + ++ + I + K+ +S+ PV NE +Y ++ +
Sbjct: 1151 SLEGVSHHAAIEILQNAPEDVTLVISQPKE---KISKVPSTPVHLTNEMKNYMKKSSYMQ 1207
Query: 141 SGRSGVVNRRSEKIWPRDRSAS-RERSLSPRSD-RRSVASSQPAKPTKVTLVKSRKNEEY 198
S + + + W R E S P R SSQ ++ +L +S+ N +
Sbjct: 1208 D--SAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFF 1265
Query: 199 GLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKM 258
L + + + E + N + T+ ++D +R +
Sbjct: 1266 ASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDE 1325
Query: 259 VVQRDERATLLNVPDLSDSIHSAN----------ASERDDISEIQSLASDHSGRSHDRPP 308
+ + S S++++N + DI E++ +D+S
Sbjct: 1326 ATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVL 1385
Query: 309 RRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVS---TPVKHADDHTPK 365
+ R PQ + R +R+ VS K A +
Sbjct: 1386 FDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN 1445
Query: 366 TVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGIL---RPSM 422
T + V + + Q+P+ E PV Q D + + V + +D +
Sbjct: 1446 TGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTF 1505
Query: 423 KLVKFRKGDSVGLRLAGGNDV--------GIFVAGVLEDSPAAKEG-LEEGDQILRVNNV 473
++ F+ +G + +++ + V + PAA+ G ++ GD IL+VN
Sbjct: 1506 EVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGA 1565
Query: 474 DFTNIIREEAV 484
+ ++E +
Sbjct: 1566 SLKGLSQQEVI 1576
Score = 43.5 bits (101), Expect = 0.002
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 17/156 (10%)
Query: 374 RNEKQTPSLPEPKPVYA------QVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKF 427
++E + S+ +P Y G +P+ +D VL + LV
Sbjct: 1038 KHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKEND-VLHKRWSIVSSPEREITLVNL 1096
Query: 428 RKGDSVGL--RLAGGN-----DVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
+K GL ++ GG D+GIF++ V PA +G L+ GD+++ VN+V +
Sbjct: 1097 KKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVS 1156
Query: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDV 515
A+ L + P E+VT++ + K+ ++ + V
Sbjct: 1157 HHAAIEILQNAP--EDVTLVISQPKEKISKVPSTPV 1190
Score = 40.0 bits (92), Expect = 0.020
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 7/81 (8%)
Query: 187 VTLVKSRKNEEYGLRLASH-----IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS 241
+TL+KS K G + +V ++ QD A DG ++ GD ++K+N T NM+
Sbjct: 1794 ITLIKSEKGS-LGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMT 1851
Query: 242 LTDAKTLIERSKGKLKMVVQR 262
TDA L+ + +++V+ R
Sbjct: 1852 HTDAVNLLRAASKTVRLVIGR 1872
Score = 38.5 bits (88), Expect = 0.058
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
+++ +I+ S+AA +GN+Q DV+ +NG T+ M+L + ++ S L +V + R
Sbjct: 1913 VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS---LPSLVLKATR 1969
Query: 266 ATLLNVPDLSDSIHSANASER 286
L VP S SA S +
Sbjct: 1970 NDLPVVPSSKRSAVSAPKSTK 1990
Score = 34.7 bits (78), Expect = 0.84
Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 7/79 (8%)
Query: 55 VISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV-- 112
VI D K ++G+L+ DR+ VN + N+ H AV LR + K ++ I R ++
Sbjct: 1822 VIQDPAK---SDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPR 1878
Query: 113 --QIPVSRPDPEPVSDNEE 129
+P PD + EE
Sbjct: 1879 IPMLPHLLPDITLTCNKEE 1897
>gi|32261318 unc-5 homolog B [Homo sapiens]
Length = 945
Score = 71.6 bits (174), Expect = 6e-12
Identities = 38/85 (44%), Positives = 51/85 (60%), Gaps = 2/85 (2%)
Query: 1634 ATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETL 1693
++ G F GG LS TGVS+++P GAIP+G E+Y + + S LP E +T+
Sbjct: 543 SSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPL--SEGTQTV 600
Query: 1694 LSPLVMCGPHGLKFLKPVELRLPHC 1718
LSP V CGP GL +PV L +PHC
Sbjct: 601 LSPSVTCGPTGLLLCRPVILTMPHC 625
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 70.9 bits (172), Expect = 1e-11
Identities = 133/635 (20%), Positives = 244/635 (38%), Gaps = 136/635 (21%)
Query: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAM 77
E + V L R GFG I ++ P G I V++G PA+ G+L+ D ++
Sbjct: 848 EPYDVVLQRKENEGFGFVILTSKNKP--PPGVIPHKIGRVIEGSPADRCGKLKVGDHISA 905
Query: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDP---EPVSDNEEDSYDE 134
VNG S+ + H VQ ++ +G +T+ +++ P S + P + +
Sbjct: 906 VNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQ 965
Query: 135 EIHDP--RSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKS 192
H P RS G + + D S S S S D + +A A +++V S
Sbjct: 966 ANHIPGDRSALEGEIGK--------DVSTSYRHSWS---DHKHLAQPDTAV---ISVVGS 1011
Query: 193 RKNEEYG----------------LRLASH----IFVKEISQDSLAARDGNIQEGDVVLKI 232
R N+ G LR +F+ +++D A +DG I GD +++I
Sbjct: 1012 RHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071
Query: 233 NGTVTENMSLTDAKTLIERSKGKLKMVVQ-----------------------RDERATL- 268
NG T+ ++ T A LI+ K+ ++++ DE++ L
Sbjct: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLP 1131
Query: 269 -----------LNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRS---R 314
+VP + +S+ + +++ +I + S + ++P + +S +
Sbjct: 1132 PSSHFASIFEESHVPVIEESLRVQICEKAEELKDI--VPEKKSTLNENQPEIKHQSLLQK 1189
Query: 315 SPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTV-- 372
+ +R PS H SN + E +++ G +P K A H+ + ++++
Sbjct: 1190 NVSKRDPPSSHGH------SNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPL 1243
Query: 373 -------ERNEKQTPSLPEPK--PVYAQVGQPDVDLPVSPSDGVLPNSTHE-DGILRPSM 422
R++ +PS E K V + G S P + +G PS
Sbjct: 1244 KNNPKRRPRDQSLSPSKGENKSCQVSTRAGSGQDQCRKSRGRSASPKKQQKIEGSKAPSN 1303
Query: 423 KLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREE 482
K +G S R+AG + E P KE +++IR++
Sbjct: 1304 AEAKLLEGKS--RRIAG------YTGSNAEQIPDGKEK---------------SDVIRKD 1340
Query: 483 AVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEV 542
A L+ + T +KK +R+VE + +T + E+ G GE
Sbjct: 1341 AKQNQLEKSR----TRSPEKK---IKRMVEKSLPSKMTNKTTSKEVSENEKGKKVTTGET 1393
Query: 543 FRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNK 577
+ N K+G + + + +E E ++ NK
Sbjct: 1394 -----SSSNDKIGENVQLSEKRLKQEPEEKVVSNK 1423
Score = 45.4 bits (106), Expect = 5e-04
Identities = 48/219 (21%), Positives = 93/219 (42%), Gaps = 16/219 (7%)
Query: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
GFG I GG D P + + + +VLK GPA +G++ D + +NG + HA
Sbjct: 419 GFGFTIIGG-DRP-----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDP-------EPVSDNEEDSYDEEIHDPRSGR 143
VQ + N + + + +P DP PV + + + E +P+ +
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFK 532
Query: 144 SGVVNRRSEKIWPRDRSASRERSLSPRSDRR-SVASSQPAKPTKVTLVKSRKNEEYGLRL 202
G + + S S++R S+ASS ++P VT+ + + +G +
Sbjct: 533 PGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAI 592
Query: 203 ASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS 241
A +++ + +Q+GD++ +I +N++
Sbjct: 593 ADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLT 631
Score = 35.8 bits (81), Expect = 0.38
Identities = 38/131 (29%), Positives = 60/131 (45%), Gaps = 18/131 (13%)
Query: 121 PEPVSDNEEDSYDEEIHDPRSGRSGV--VNRRSEKIWPRDRSASRERSL------SPRSD 172
PE D E E+I DP+ G V +N++++ P + A R++ L S + D
Sbjct: 333 PEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEE-AKRKKQLGQVEIGSSKPD 391
Query: 173 -RRSVASSQPAKPTKVTLVKSRKNEEYGL--------RLASHIFVKEISQDSLAARDGNI 223
+S + P++ V + S K G R + VK + +D AA+DG I
Sbjct: 392 MEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKI 451
Query: 224 QEGDVVLKING 234
GDV++ ING
Sbjct: 452 APGDVIVDING 462
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.129 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,349,746
Number of Sequences: 37866
Number of extensions: 4637049
Number of successful extensions: 25304
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 201
Number of HSP's successfully gapped in prelim test: 820
Number of HSP's that attempted gapping in prelim test: 18619
Number of HSP's gapped (non-prelim): 6511
length of query: 1748
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1632
effective length of database: 13,855,062
effective search space: 22611461184
effective search space used: 22611461184
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.