Search of human proteins with 226054295

Search of human proteins with 226054295

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226054295 TOX high mobility group box family member 3
isoform 1 [Homo sapiens]
         (576 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226054295 TOX high mobility group box family member 3 isoform...  1135   0.0  
gi|226246533 TOX high mobility group box family member 3 isoform...  1071   0.0  
gi|7662322 thymus high mobility group box protein TOX [Homo sapi...   380   e-105
gi|7662274 epidermal Langerhans cell protein LCP1 [Homo sapiens]      339   4e-93
gi|149408144 TOX high mobility group box family member 2 isoform...   296   3e-80
gi|149408141 TOX high mobility group box family member 2 isoform...   277   2e-74
gi|14249636 TOX high mobility group box family member 2 isoform ...   277   2e-74
gi|149408146 TOX high mobility group box family member 2 isoform...   234   2e-61
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]       99   8e-21
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]       99   8e-21
gi|33286444 mastermind-like 2 [Homo sapiens]                           97   3e-20
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    97   5e-20
gi|110347429 mediator complex subunit 12 [Homo sapiens]                96   7e-20
gi|17017963 forkhead box P2 isoform I [Homo sapiens]                   95   2e-19
gi|149999352 forkhead box P2 isoform II [Homo sapiens]                 94   3e-19
gi|93141033 PAX interacting protein 1 [Homo sapiens]                   94   3e-19
gi|22538413 forkhead box P2 isoform III [Homo sapiens]                 93   8e-19
gi|221139761 zinc finger protein 853 [Homo sapiens]                    92   1e-18
gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]            82   1e-15
gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]            82   1e-15
gi|169202818 PREDICTED: similar to hCG1991922 [Homo sapiens]           80   4e-15
gi|239749996 PREDICTED: similar to hCG1991922 [Homo sapiens]           80   4e-15
gi|239744307 PREDICTED: similar to hCG1991922 [Homo sapiens]           80   4e-15
gi|4504425 high-mobility group box 1 [Homo sapiens]                    79   1e-14
gi|4507241 structure specific recognition protein 1 [Homo sapiens]     79   1e-14
gi|56549696 E1A binding protein p400 [Homo sapiens]                    77   3e-14
gi|19923236 nuclear antigen Sp100 isoform 2 [Homo sapiens]             77   4e-14
gi|194688135 high-mobility group box 2 [Homo sapiens]                  77   6e-14
gi|194688133 high-mobility group box 2 [Homo sapiens]                  77   6e-14
gi|11321591 high-mobility group box 2 [Homo sapiens]                   77   6e-14

>gi|226054295 TOX high mobility group box family member 3 isoform 1
           [Homo sapiens]
          Length = 576

 Score = 1135 bits (2937), Expect = 0.0
 Identities = 576/576 (100%), Positives = 576/576 (100%)

Query: 1   MDVRFYPAAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANNAFFAASEQTFHTPSLG 60
           MDVRFYPAAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANNAFFAASEQTFHTPSLG
Sbjct: 1   MDVRFYPAAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANNAFFAASEQTFHTPSLG 60

Query: 61  DEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITISR 120
           DEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITISR
Sbjct: 61  DEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITISR 120

Query: 121 NLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQS 180
           NLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQS
Sbjct: 121 NLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQS 180

Query: 181 QLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRAAPDSGKK 240
           QLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRAAPDSGKK
Sbjct: 181 QLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRAAPDSGKK 240

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ
Sbjct: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300

Query: 301 KQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNT 360
           KQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNT
Sbjct: 301 KQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNT 360

Query: 361 PLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMG 420
           PLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMG
Sbjct: 361 PLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMG 420

Query: 421 TTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQ 480
           TTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQ
Sbjct: 421 TTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQ 480

Query: 481 HFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQI 540
           HFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQI
Sbjct: 481 HFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQI 540

Query: 541 TSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQVSIF 576
           TSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQVSIF
Sbjct: 541 TSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQVSIF 576


>gi|226246533 TOX high mobility group box family member 3 isoform 2
           [Homo sapiens]
          Length = 571

 Score = 1072 bits (2771), Expect = 0.0
 Identities = 548/550 (99%), Positives = 548/550 (99%), Gaps = 1/550 (0%)

Query: 27  YSKFGNNNNYMNMAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPALGMPDVLL 86
           Y KFGNNNNYMNMAEANNAFFAASE TFHTPSLGDEEFEIPPITPPPESDPALGMPDVLL
Sbjct: 23  YLKFGNNNNYMNMAEANNAFFAASE-TFHTPSLGDEEFEIPPITPPPESDPALGMPDVLL 81

Query: 87  PFQALSDPLPSQGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQY 146
           PFQALSDPLPSQGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQY
Sbjct: 82  PFQALSDPLPSQGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQY 141

Query: 147 RQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASK 206
           RQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASK
Sbjct: 142 RQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASK 201

Query: 207 SATPSPSSSINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFF 266
           SATPSPSSSINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFF
Sbjct: 202 SATPSPSSSINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFF 261

Query: 267 RDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASL 326
           RDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASL
Sbjct: 262 RDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASL 321

Query: 327 VSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPK 386
           VSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPK
Sbjct: 322 VSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPK 381

Query: 387 PLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQ 446
           PLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQ
Sbjct: 382 PLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQ 441

Query: 447 QQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQL 506
           QQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQL
Sbjct: 442 QQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQL 501

Query: 507 QQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQ 566
           QQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQ
Sbjct: 502 QQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQ 561

Query: 567 TQVLSQVSIF 576
           TQVLSQVSIF
Sbjct: 562 TQVLSQVSIF 571


>gi|7662322 thymus high mobility group box protein TOX [Homo
           sapiens]
          Length = 526

 Score =  380 bits (976), Expect = e-105
 Identities = 242/494 (48%), Positives = 305/494 (61%), Gaps = 48/494 (9%)

Query: 1   MDVRFYP-----AAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANNAFFAASEQTFH 55
           MDVRFYP     AAA D   L  + CL  Y  +KF   N YM+M E +  +  AS Q++ 
Sbjct: 1   MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPAS-QSYP 59

Query: 56  TPSLGDEEFEIPPITPPPESDPAL-GMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLP 114
            PSL  E+F IPPITPP   D +L  + +V   + +L  P+   G      F PQ++DLP
Sbjct: 60  GPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNG---LLPFHPQNMDLP 116

Query: 115 SITISRNLVEQDGVLHSSGLHM--DQSHTQVSQYRQDPSLI-MRSIVHMTDAARS-GVMP 170
            IT+S N++ QDG L S+ + +  D  + + +QY   P +  MR      D  +  G+MP
Sbjct: 117 EITVS-NMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMP 175

Query: 171 PAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIG- 229
             QLTTINQSQLSAQLGLN+GG+++PH SPSPP SKSATPSPSSS++E++ D+ ++  G 
Sbjct: 176 HGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGG 235

Query: 230 EKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIV 289
           EKR A D GKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIV
Sbjct: 236 EKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIV 295

Query: 290 ASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLAS 349
           ASMWD LGEEQKQVYK+KTEAAKKEYLK LAAYRASLVSK+ +E  + +T +  Q   + 
Sbjct: 296 ASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSK 355

Query: 350 TNL-------TSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVT 402
            ++        S+L L++   Q   ++     +  SLPR+IAPK      P NQ+  +V+
Sbjct: 356 PSVFHGPSQAHSALYLSSHYHQQPGMNPHLTAMHPSLPRNIAPK------PNNQMPVTVS 409

Query: 403 IAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQ 462
           I ANM                V   P  Q+SP +   QH + +QQ Q    QQ    Q  
Sbjct: 410 I-ANM---------------AVSPPPPLQISPPL--HQH-LNMQQHQPLTMQQPLGNQLP 450

Query: 463 QLQQHQMHQQIQQQ 476
              Q  +H    QQ
Sbjct: 451 MQVQSALHSPTMQQ 464


>gi|7662274 epidermal Langerhans cell protein LCP1 [Homo sapiens]
          Length = 621

 Score =  339 bits (870), Expect = 4e-93
 Identities = 224/541 (41%), Positives = 309/541 (57%), Gaps = 37/541 (6%)

Query: 31  GNNNNYMNMAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPALGMPDVLLPFQA 90
           G N+NY+ +   ++ F + +E TFHTPSLGDEEFEIPPI+   +SDP+L + DV+  F  
Sbjct: 5   GGNDNYLTITGPSHPFLSGAE-TFHTPSLGDEEFEIPPISL--DSDPSLAVSDVVGHFDD 61

Query: 91  LSDPLPSQGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQYRQDP 150
           L+DP  SQ   F+ Q+  Q+LD+P + ++  L+EQ G L S GL MD  H+  +QY  +P
Sbjct: 62  LADPSSSQDGSFSAQYGVQTLDMP-VGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANP 120

Query: 151 SLIMRSIVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATP 210
            + +   V MTD   SG+M  +QLTTI+QS+LS+QLGL+LGG ++   + SP    S TP
Sbjct: 121 PVTID--VPMTDMT-SGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTP 177

Query: 211 SPSSSINEEDADEANRAI-GEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDT 269
           SP+SS++E+  ++  R +  +K    ++GKK K PKK+KKKDPNEPQKPVSAYALFFRDT
Sbjct: 178 SPTSSLHEDGVEDFRRQLPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDT 237

Query: 270 QAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSK 329
           QAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAY+ +   +
Sbjct: 238 QAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQ 297

Query: 330 AAAESAEAQ--------------TIRSVQQTLASTN---LTSSLLLNTPLSQHGTVSAS- 371
           A  E+ E                T+       AS     L+ S+++N+ LS +    AS 
Sbjct: 298 ATVETVELDPAPPSQTPSPPPMATVDPASPAPASIEPPALSPSIVVNSTLSSYVANQASS 357

Query: 372 -----PQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGS 426
                P   +  + + + P  +T    M+Q      I A + ++ G  L  +   T+  S
Sbjct: 358 GAGGQPNITKLIITKQMLPSSIT----MSQGGMVTVIPATVVTSRGLQLGQTSTATIQPS 413

Query: 427 APSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHM 486
             +  V+ SV             Q    ++Q    QQ+ Q    QQ+    Q    Q   
Sbjct: 414 QQAQIVTRSVLQAAAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQ 473

Query: 487 QQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQ--LQHMQHQSQPSPRQHSPVASQITSPI 544
           Q   Q+ + +LQQQ    Q++      L++Q   +      S   P  +SP A  + +P 
Sbjct: 474 QPPPQKVRINLQQQPPPLQIKSVPLPTLKMQTTLVPPTVESSPERPMNNSPEAHTVEAPS 533

Query: 545 P 545
           P
Sbjct: 534 P 534


>gi|149408144 TOX high mobility group box family member 2 isoform a
           [Homo sapiens]
          Length = 506

 Score =  296 bits (759), Expect = 3e-80
 Identities = 205/474 (43%), Positives = 271/474 (57%), Gaps = 59/474 (12%)

Query: 1   MDVRFYPAA-------AGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANNAFFAASEQT 53
           MDVR YP+A         +PA L     L YY   KF  ++ Y+ M++ N    + S QT
Sbjct: 1   MDVRLYPSAPAVGARPGAEPAGLAH---LDYYHGGKFDGDSAYVGMSDGNPELLSTS-QT 56

Query: 54  FHTPSLGDEEFEIPPITPPPESDPAL-GMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLD 112
           ++  S  +E++EIPPITPP   +P+L  + D    + +L   L   G    P +  Q++D
Sbjct: 57  YNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNG--LLPAYSYQAMD 114

Query: 113 LPSITISRNLVEQDGVLHSSGLHMDQS--HTQVSQYRQDPSLIMRSIVHMTDAARSG--- 167
           LP+I +S N++ QD  L S  L   Q   H++V+ Y               D+ R G   
Sbjct: 115 LPAIMVS-NMLAQDSHLLSGQLPTIQEMVHSEVAAY---------------DSGRPGPLL 158

Query: 168 ---VMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEA 224
               M  + ++ ++QSQL +Q+G+    +S+ H+SPSPP SKSATPSPSSS  EE+++  
Sbjct: 159 GRPAMLASHMSALSQSQLISQMGIR---SSIAHSSPSPPGSKSATPSPSSSTQEEESEVH 215

Query: 225 NRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGE 284
            +  GEKR + D GKK K PKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNP+ATFG+
Sbjct: 216 FKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGD 275

Query: 285 VSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAE-------- 336
           VSKIVASMWDSLGEEQKQ YKRKTEAAKKEYLKALAAYRASLVSK++ +  E        
Sbjct: 276 VSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSSPDQGETKSTQANP 335

Query: 337 -AQTIRSVQQTLASTNLTSSLLLNTPLS-QHGTVSASPQTLQQSL-PRSIAPKPLTMRLP 393
            A+ +   Q   A   L S L   TP   Q     ASP +L ++L  +S+ P       P
Sbjct: 336 PAKMLPPKQPMYAMPGLASFL---TPSDLQAFRSGASPASLARTLGSKSLLPGLSASPPP 392

Query: 394 MNQIVTSVTI--AANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQL 445
                 S T+    ++P +    L+S      +  AP   V P+    Q Q+ +
Sbjct: 393 PPSFPLSPTLHQQLSLPPHAQGALLSP--PVSMSPAPQPPVLPTPMALQVQLAM 444


>gi|149408141 TOX high mobility group box family member 2 isoform c
           [Homo sapiens]
          Length = 464

 Score =  277 bits (708), Expect = 2e-74
 Identities = 189/429 (44%), Positives = 250/429 (58%), Gaps = 49/429 (11%)

Query: 39  MAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPAL-GMPDVLLPFQALSDPLPS 97
           M++ N    + S QT++  S  +E++EIPPITPP   +P+L  + D    + +L   L  
Sbjct: 1   MSDGNPELLSTS-QTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTP 59

Query: 98  QGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQS--HTQVSQYRQDPSLIMR 155
            G    P +  Q++DLP+I +S N++ QD  L S  L   Q   H++V+ Y         
Sbjct: 60  NG--LLPAYSYQAMDLPAIMVS-NMLAQDSHLLSGQLPTIQEMVHSEVAAY--------- 107

Query: 156 SIVHMTDAARSG------VMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSAT 209
                 D+ R G       M  + ++ ++QSQL +Q+G+    +S+ H+SPSPP SKSAT
Sbjct: 108 ------DSGRPGPLLGRPAMLASHMSALSQSQLISQMGIR---SSIAHSSPSPPGSKSAT 158

Query: 210 PSPSSSINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDT 269
           PSPSSS  EE+++   +  GEKR + D GKK K PKKKKKKDPNEPQKPVSAYALFFRDT
Sbjct: 159 PSPSSSTQEEESEVHFKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDT 218

Query: 270 QAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSK 329
           QAAIKGQNP+ATFG+VSKIVASMWDSLGEEQKQ YKRKTEAAKKEYLKALAAYRASLVSK
Sbjct: 219 QAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSK 278

Query: 330 AAAESAE---------AQTIRSVQQTLASTNLTSSLLLNTPLS-QHGTVSASPQTLQQSL 379
           ++ +  E         A+ +   Q   A   L S L   TP   Q     ASP +L ++L
Sbjct: 279 SSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFL---TPSDLQAFRSGASPASLARTL 335

Query: 380 -PRSIAPKPLTMRLPMNQIVTSVTI--AANMPSNIGAPLISSMGTTMVGSAPSTQVSPSV 436
             +S+ P       P      S T+    ++P +    L+S      +  AP   V P+ 
Sbjct: 336 GSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSP--PVSMSPAPQPPVLPTP 393

Query: 437 QTQQHQMQL 445
              Q Q+ +
Sbjct: 394 MALQVQLAM 402


>gi|14249636 TOX high mobility group box family member 2 isoform c
           [Homo sapiens]
          Length = 464

 Score =  277 bits (708), Expect = 2e-74
 Identities = 189/429 (44%), Positives = 250/429 (58%), Gaps = 49/429 (11%)

Query: 39  MAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPAL-GMPDVLLPFQALSDPLPS 97
           M++ N    + S QT++  S  +E++EIPPITPP   +P+L  + D    + +L   L  
Sbjct: 1   MSDGNPELLSTS-QTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTP 59

Query: 98  QGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQS--HTQVSQYRQDPSLIMR 155
            G    P +  Q++DLP+I +S N++ QD  L S  L   Q   H++V+ Y         
Sbjct: 60  NG--LLPAYSYQAMDLPAIMVS-NMLAQDSHLLSGQLPTIQEMVHSEVAAY--------- 107

Query: 156 SIVHMTDAARSG------VMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSAT 209
                 D+ R G       M  + ++ ++QSQL +Q+G+    +S+ H+SPSPP SKSAT
Sbjct: 108 ------DSGRPGPLLGRPAMLASHMSALSQSQLISQMGIR---SSIAHSSPSPPGSKSAT 158

Query: 210 PSPSSSINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDT 269
           PSPSSS  EE+++   +  GEKR + D GKK K PKKKKKKDPNEPQKPVSAYALFFRDT
Sbjct: 159 PSPSSSTQEEESEVHFKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDT 218

Query: 270 QAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSK 329
           QAAIKGQNP+ATFG+VSKIVASMWDSLGEEQKQ YKRKTEAAKKEYLKALAAYRASLVSK
Sbjct: 219 QAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSK 278

Query: 330 AAAESAE---------AQTIRSVQQTLASTNLTSSLLLNTPLS-QHGTVSASPQTLQQSL 379
           ++ +  E         A+ +   Q   A   L S L   TP   Q     ASP +L ++L
Sbjct: 279 SSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFL---TPSDLQAFRSGASPASLARTL 335

Query: 380 -PRSIAPKPLTMRLPMNQIVTSVTI--AANMPSNIGAPLISSMGTTMVGSAPSTQVSPSV 436
             +S+ P       P      S T+    ++P +    L+S      +  AP   V P+ 
Sbjct: 336 GSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSP--PVSMSPAPQPPVLPTP 393

Query: 437 QTQQHQMQL 445
              Q Q+ +
Sbjct: 394 MALQVQLAM 402


>gi|149408146 TOX high mobility group box family member 2 isoform b
           [Homo sapiens]
          Length = 488

 Score =  234 bits (597), Expect = 2e-61
 Identities = 168/462 (36%), Positives = 239/462 (51%), Gaps = 74/462 (16%)

Query: 18  FAQCLGYYGY------------------SKFGNNNNYMNMAEANNAFFAASEQTFHTPSL 59
           F++CLG+ G                    KF  ++ Y+ M++ N    + S QT++  S 
Sbjct: 13  FSRCLGFCGMRLGLLLLARHWCIAGVFPQKFDGDSAYVGMSDGNPELLSTS-QTYNGQSE 71

Query: 60  GDEEFEIPPITPPPESDPAL-GMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITI 118
            +E++EIPPITPP   +P+L  + D    + +L   L   G    P +  Q++DLP+I +
Sbjct: 72  NNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNG--LLPAYSYQAMDLPAIMV 129

Query: 119 SRNLVEQDGVLHSSGLHMDQS--HTQVSQYRQDPSLIMRSIVHMTDAARSG------VMP 170
           S N++ QD  L S  L   Q   H++V+ Y               D+ R G       M 
Sbjct: 130 S-NMLAQDSHLLSGQLPTIQEMVHSEVAAY---------------DSGRPGPLLGRPAML 173

Query: 171 PAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGE 230
            + ++ ++QSQL +Q+G+    +S+ H+SPSPP SKSATPSPSSS  EE+++   +  GE
Sbjct: 174 ASHMSALSQSQLISQMGIR---SSIAHSSPSPPGSKSATPSPSSSTQEEESEVHFKISGE 230

Query: 231 KRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVA 290
           KR + D GKK K PKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNP+ATFG+VSKIVA
Sbjct: 231 KRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVA 290

Query: 291 SMWDSLGEEQKQVYKRKTEAAK------------KEYLKALAAYRASLVSKAAAESAEAQ 338
           SMWDSLGEEQKQ    + E               K+ + A+    + L            
Sbjct: 291 SMWDSLGEEQKQSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGA 350

Query: 339 TIRSVQQTLASTNLTSSLLLNTP--------LSQHGTVSASPQT----LQQSLPRSIAPK 386
           +  S+ +TL S +L   L  + P         + H  +S  P      L   +  S AP+
Sbjct: 351 SPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSPPVSMSPAPQ 410

Query: 387 PLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAP 428
           P  +  PM  +   + ++ + P     P IS   ++    +P
Sbjct: 411 PPVLPTPM-ALQVQLAMSPSPPGPQDFPHISEFPSSSGSCSP 451


>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
          Length = 788

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 72/155 (46%), Positives = 83/155 (53%), Gaps = 24/155 (15%)

Query: 426 SAPSTQVS---PSVQTQQHQMQLQQQQQ---QQQQQMQQMQQQQLQQHQMHQQI------ 473
           + P TQ+     ++Q QQ Q Q QQQQQ   QQQQQ QQ QQ Q QQ  M QQ       
Sbjct: 147 ATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQ 206

Query: 474 -----QQQMQQQH---FQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQ 525
                QQQ QQQH     H  QQ +QQQQQ L Q+I Q QLQQQ QQ+ Q QQ Q    Q
Sbjct: 207 QQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQL-QRIAQLQLQQQQQQQQQQQQQQQQALQ 265

Query: 526 SQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQ 560
           +QP P Q  P+  Q   P P+   PQ   Q H +Q
Sbjct: 266 AQP-PIQQPPM--QQPQPPPSQALPQQLQQMHHTQ 297



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 73/163 (44%), Positives = 81/163 (49%), Gaps = 19/163 (11%)

Query: 425 GSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQH 484
           G AP +    S  T Q Q+QLQQ   QQQQQ QQ QQQQ    Q  QQ QQQ Q Q  Q 
Sbjct: 135 GMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQS 194

Query: 485 HMQQHLQ---QQQQHLQQQ------------INQQQLQQQLQQRLQLQQLQ-HMQHQSQP 528
            MQQ  Q   QQQQ LQQQ             NQQQ+QQQ QQ  ++ QLQ   Q Q Q 
Sbjct: 195 AMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQ 254

Query: 529 SPRQHSPVASQITSPI--PAIGSPQ-PASQQHQSQIQSQTQTQ 568
             +Q    A Q   PI  P +  PQ P SQ    Q+Q    TQ
Sbjct: 255 QQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQ 297



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 63/154 (40%), Positives = 70/154 (45%), Gaps = 17/154 (11%)

Query: 431 QVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHL 490
           Q   S   QQ Q  +QQQQQ QQQQ QQ    +L  HQ  QQIQQQ QQ      +Q   
Sbjct: 190 QAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKL-HHQNQQQIQQQQQQLQRIAQLQLQQ 248

Query: 491 QQQQQHLQQQINQQQLQQQ--LQQ--------------RLQLQQLQHMQHQSQPSPRQHS 534
           QQQQQ  QQQ  QQ LQ Q  +QQ                QLQQ+ H QH   P   Q  
Sbjct: 249 QQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQP 308

Query: 535 PVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQ 568
           PVA    S +P     QP   Q Q+       TQ
Sbjct: 309 PVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQ 342



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 55/151 (36%), Positives = 67/151 (44%), Gaps = 16/151 (10%)

Query: 437 QTQQHQMQLQ-------QQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQH 489
           Q QQ Q QLQ       QQQQQQQQQ QQ QQQ LQ     QQ   Q  Q      + Q 
Sbjct: 230 QIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQ 289

Query: 490 LQQQQ--QHLQQQINQQQ---LQQQLQQRLQLQQLQHMQHQSQPSPRQ---HSPVASQIT 541
           LQQ    QH Q     QQ    Q Q  Q     Q Q +  Q+Q  P Q     P    + 
Sbjct: 290 LQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVR 349

Query: 542 SPIPAIGSP-QPASQQHQSQIQSQTQTQVLS 571
           +P+     P QP  QQ Q+ +Q+    Q+++
Sbjct: 350 APMVVQQPPVQPQVQQQQTAVQTAQAAQMVA 380



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 57/221 (25%), Positives = 72/221 (32%), Gaps = 91/221 (41%)

Query: 431 QVSPSVQTQQHQMQ----LQQQQQQQQQQMQQMQQQQ-------LQQHQMHQQ------- 472
           Q    +Q QQ Q+Q    LQ QQQQQQQQ QQ QQQQ       +QQ  M Q        
Sbjct: 226 QNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQA 285

Query: 473 IQQQMQQQHFQHHMQQHLQQQQQHLQQ--------------------------------- 499
           + QQ+QQ H   H Q   Q QQ  + Q                                 
Sbjct: 286 LPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPL 345

Query: 500 ----------------QINQQQLQQQLQQRLQL-------------QQLQHMQHQSQPS- 529
                           Q+ QQQ   Q  Q  Q+             Q   H++ +  P+ 
Sbjct: 346 KFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTT 405

Query: 530 ----------PRQHSPVASQITSPIPAIGSPQPASQQHQSQ 560
                     P    P+A    S +P + SP P  Q    Q
Sbjct: 406 AVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQ 446



 Score = 34.3 bits (77), Expect = 0.32
 Identities = 45/202 (22%), Positives = 78/202 (38%), Gaps = 24/202 (11%)

Query: 67  PPITPPP----ESDPALGMPDVLLPFQALSDPLPSQGSEFTP-------QFPPQSLDLPS 115
           PPI  PP    +  P+  +P  L          P    +  P       Q PPQS   P 
Sbjct: 268 PPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPL 327

Query: 116 ITISRNLVEQDGVLHSSG-LHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQL 174
           ++ ++ L  Q  +L++   L   ++   V Q    P +  +     T  A   V P  Q+
Sbjct: 328 VSQAQALPGQ--MLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQM 385

Query: 175 TTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRAA 234
            T    +  AQ G+++     P T+ S      A PS S  +  +   + +++     ++
Sbjct: 386 IT----EALAQGGMHIRARFPPTTAVS------AIPSSSIPLGRQPMAQVSQSSLPMLSS 435

Query: 235 PDSGKKPKTPKKKKKKDPNEPQ 256
           P  G++ +TP+         PQ
Sbjct: 436 PSPGQQVQTPQSMPPPPQPSPQ 457


>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
          Length = 748

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 72/155 (46%), Positives = 83/155 (53%), Gaps = 24/155 (15%)

Query: 426 SAPSTQVS---PSVQTQQHQMQLQQQQQ---QQQQQMQQMQQQQLQQHQMHQQI------ 473
           + P TQ+     ++Q QQ Q Q QQQQQ   QQQQQ QQ QQ Q QQ  M QQ       
Sbjct: 147 ATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQ 206

Query: 474 -----QQQMQQQH---FQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQ 525
                QQQ QQQH     H  QQ +QQQQQ L Q+I Q QLQQQ QQ+ Q QQ Q    Q
Sbjct: 207 QQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQL-QRIAQLQLQQQQQQQQQQQQQQQQALQ 265

Query: 526 SQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQ 560
           +QP P Q  P+  Q   P P+   PQ   Q H +Q
Sbjct: 266 AQP-PIQQPPM--QQPQPPPSQALPQQLQQMHHTQ 297



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 73/163 (44%), Positives = 81/163 (49%), Gaps = 19/163 (11%)

Query: 425 GSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQH 484
           G AP +    S  T Q Q+QLQQ   QQQQQ QQ QQQQ    Q  QQ QQQ Q Q  Q 
Sbjct: 135 GMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQS 194

Query: 485 HMQQHLQ---QQQQHLQQQ------------INQQQLQQQLQQRLQLQQLQ-HMQHQSQP 528
            MQQ  Q   QQQQ LQQQ             NQQQ+QQQ QQ  ++ QLQ   Q Q Q 
Sbjct: 195 AMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQ 254

Query: 529 SPRQHSPVASQITSPI--PAIGSPQ-PASQQHQSQIQSQTQTQ 568
             +Q    A Q   PI  P +  PQ P SQ    Q+Q    TQ
Sbjct: 255 QQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQ 297



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 63/154 (40%), Positives = 70/154 (45%), Gaps = 17/154 (11%)

Query: 431 QVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHL 490
           Q   S   QQ Q  +QQQQQ QQQQ QQ    +L  HQ  QQIQQQ QQ      +Q   
Sbjct: 190 QAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKL-HHQNQQQIQQQQQQLQRIAQLQLQQ 248

Query: 491 QQQQQHLQQQINQQQLQQQ--LQQ--------------RLQLQQLQHMQHQSQPSPRQHS 534
           QQQQQ  QQQ  QQ LQ Q  +QQ                QLQQ+ H QH   P   Q  
Sbjct: 249 QQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQP 308

Query: 535 PVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQ 568
           PVA    S +P     QP   Q Q+       TQ
Sbjct: 309 PVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQ 342



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 55/151 (36%), Positives = 67/151 (44%), Gaps = 16/151 (10%)

Query: 437 QTQQHQMQLQ-------QQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQH 489
           Q QQ Q QLQ       QQQQQQQQQ QQ QQQ LQ     QQ   Q  Q      + Q 
Sbjct: 230 QIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQ 289

Query: 490 LQQQQ--QHLQQQINQQQ---LQQQLQQRLQLQQLQHMQHQSQPSPRQ---HSPVASQIT 541
           LQQ    QH Q     QQ    Q Q  Q     Q Q +  Q+Q  P Q     P    + 
Sbjct: 290 LQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVR 349

Query: 542 SPIPAIGSP-QPASQQHQSQIQSQTQTQVLS 571
           +P+     P QP  QQ Q+ +Q+    Q+++
Sbjct: 350 APMVVQQPPVQPQVQQQQTAVQTAQAAQMVA 380



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 59/203 (29%), Positives = 74/203 (36%), Gaps = 74/203 (36%)

Query: 431 QVSPSVQTQQHQMQ----LQQQQQQQQQQMQQMQQQQ-------LQQHQMHQQ------- 472
           Q    +Q QQ Q+Q    LQ QQQQQQQQ QQ QQQQ       +QQ  M Q        
Sbjct: 226 QNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQA 285

Query: 473 IQQQMQQQHF-QHHMQQHLQQQQQHLQQQINQQQLQQQLQQRL-QLQQLQHMQHQSQPSP 530
           + QQ+QQ H  QHH      QQ    Q Q +Q   Q Q Q  + Q Q L      +QP  
Sbjct: 286 LPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPL 345

Query: 531 R--------QHSPVASQIT-----------------------SPIPAIGSP--------- 550
           +        Q  PV  Q+                        S +P + SP         
Sbjct: 346 KFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTP 405

Query: 551 --------------QPASQQHQS 559
                         QP+SQ + +
Sbjct: 406 QSMPPPPQPSPQPGQPSSQPNSN 428


>gi|33286444 mastermind-like 2 [Homo sapiens]
          Length = 1156

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 68/158 (43%), Positives = 77/158 (48%), Gaps = 11/158 (6%)

Query: 426 SAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHH 485
           S  + Q  PSV   Q++  L    QQQQQQ QQ QQQQ QQ Q  QQ QQQ QQQ  Q  
Sbjct: 564 SDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSS 623

Query: 486 MQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPS--PRQHSPVASQITSP 543
           +    QQQQQ       QQQ QQQ QQ+ Q QQ Q  Q Q QPS  P Q  P    + SP
Sbjct: 624 ISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSP 683

Query: 544 IPAIGSPQPASQQHQ---------SQIQSQTQTQVLSQ 572
           +P          Q+Q         SQ Q Q Q  V+ Q
Sbjct: 684 LPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQ 721



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 67/153 (43%), Positives = 76/153 (49%), Gaps = 10/153 (6%)

Query: 417 SSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQ-- 474
           S      + S   +Q  PS+     Q Q QQQQQQQQQQ QQ QQQQ QQ Q  QQ Q  
Sbjct: 564 SDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSS 623

Query: 475 ---QQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQ---SQP 528
              QQ QQQ      QQ  QQQQQ  QQQ  QQQ QQQ QQ+   Q  Q +  Q     P
Sbjct: 624 ISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSP 683

Query: 529 SPRQHSPVASQI-TSPIPAIGSPQPASQQHQSQ 560
            P Q   +  Q+   PI  +G  Q + QQ Q Q
Sbjct: 684 LPLQQKLLLQQMQNQPIAGMGY-QVSQQQRQDQ 715



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 78/243 (32%), Positives = 96/243 (39%), Gaps = 41/243 (16%)

Query: 361 PLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLI--SS 418
           P +Q G +    Q   Q L RS    P     P       +    +  +N   P +  S 
Sbjct: 519 PSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQ 578

Query: 419 MGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQ----------------- 461
              +++      Q     Q QQ Q Q QQQQQQQQQQ QQ QQ                 
Sbjct: 579 NKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISA 638

Query: 462 --QQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQ---LQQRLQL 516
             QQ QQ Q  QQ QQQ QQQ      QQ  QQ      Q +  Q L +    LQQ+L L
Sbjct: 639 QQQQQQQQQQQQQQQQQQQQQ------QQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLL 692

Query: 517 QQLQHM-------QHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQV 569
           QQ+Q+        Q   Q    QHS V  Q T P P   SP P S  +       +Q  +
Sbjct: 693 QQMQNQPIAGMGYQVSQQQRQDQHS-VVGQNTGPSP---SPNPCSNPNTGSGYMNSQQSL 748

Query: 570 LSQ 572
           L+Q
Sbjct: 749 LNQ 751



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 54/167 (32%), Positives = 66/167 (39%), Gaps = 67/167 (40%)

Query: 431 QVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQ--------------------LQQHQMH 470
           Q S S Q QQ Q Q QQQQQQQQQQ QQ QQQQ                    LQQ  + 
Sbjct: 633 QSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLL 692

Query: 471 QQIQ-------------QQMQQQHF----------------------------QHHMQQH 489
           QQ+Q             QQ Q QH                             Q  + Q 
Sbjct: 693 QQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQ 752

Query: 490 LQQQQQHLQQQINQQQLQQQLQQRLQLQ------QLQHMQHQSQPSP 530
           L  ++Q LQ+QI +Q+ Q  LQQ++         Q Q  +H S+P P
Sbjct: 753 LMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPP 799



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 40/146 (27%), Positives = 54/146 (36%), Gaps = 4/146 (2%)

Query: 431 QVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHL 490
           +  PS Q     + +QQ+ Q   +         ++  Q + +             M   L
Sbjct: 516 KAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVL 575

Query: 491 QQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQH----SPVASQITSPIPA 546
             Q +       QQQ QQQ QQ+ Q QQ Q  Q Q Q   +Q     S  A Q      +
Sbjct: 576 PSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSS 635

Query: 547 IGSPQPASQQHQSQIQSQTQTQVLSQ 572
           I + Q   QQ Q Q Q Q Q Q   Q
Sbjct: 636 ISAQQQQQQQQQQQQQQQQQQQQQQQ 661



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 35/200 (17%), Positives = 73/200 (36%), Gaps = 15/200 (7%)

Query: 298 EEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLL 357
           ++Q+Q  +++ +  +++   +++A +      + +   + Q  +  QQ            
Sbjct: 603 QQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQ 662

Query: 358 LNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLIS 417
              P SQ      S   L+  LP     + L ++   NQ +  +    +         + 
Sbjct: 663 QQQPSSQPAQSLPSQPLLRSPLPLQ---QKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVV 719

Query: 418 SMGTTMVGSAPSTQVSPSVQTQQHQMQLQQ---------QQQQQQQQMQQMQQQQLQQHQ 468
              T   G +PS     +  T    M  QQ         ++Q  Q+Q+ + +QQ L Q Q
Sbjct: 720 GQNT---GPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQ 776

Query: 469 MHQQIQQQMQQQHFQHHMQQ 488
           M    ++   Q     H+ +
Sbjct: 777 MLADAEKIAPQDQINRHLSR 796


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 64/120 (53%), Positives = 74/120 (61%), Gaps = 8/120 (6%)

Query: 429  STQVSPSVQTQQHQMQLQQQQQ-QQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQ 487
            S Q   S+Q  Q Q QLQQQQQ QQQQQ Q  QQQQLQQ    QQ+QQQ QQQ  Q   Q
Sbjct: 3890 SAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQ----QQLQQQQQQQQLQQQQQ 3945

Query: 488  QHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHM-QHQSQPSPRQHSPVASQITSPIPA 546
            Q LQQQQQ LQQQ  QQQ QQQ QQ+ Q QQ+  + Q ++  SP+Q       +   +PA
Sbjct: 3946 QQLQQQQQQLQQQ--QQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPA 4003



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 64/141 (45%), Positives = 75/141 (53%), Gaps = 8/141 (5%)

Query: 409  SNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQ--QQMQQMQQQQLQQ 466
            S++   L+S  G   + + P   +    Q QQ Q Q Q QQQQQQ  QQ QQ+QQQQLQQ
Sbjct: 3874 SHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQ 3933

Query: 467  HQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQL----QQRLQLQQLQHM 522
             Q  QQ+QQQ QQQ  Q   QQ LQQQQQ  QQQ  QQQ QQQ+    Q R  L   Q  
Sbjct: 3934 QQQQQQLQQQQQQQLQQ--QQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQ 3991

Query: 523  QHQSQPSPRQHSPVASQITSP 543
            Q Q    P   +      +SP
Sbjct: 3992 QQQVALGPGMPAKPLQHFSSP 4012



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 63/162 (38%), Positives = 75/162 (46%), Gaps = 32/162 (19%)

Query: 429  STQVSPSVQTQQHQMQLQQQQQQQQQQMQQ---------MQQQ----------------Q 463
            S Q++   Q       +  QQQQQQQQ QQ         +QQ                  
Sbjct: 3837 SPQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGS 3896

Query: 464  LQQHQMHQQIQQQMQ-QQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQ---L 519
            LQQ Q  QQ+QQQ Q QQ  Q  +QQ  Q QQQ LQQQ  QQQLQQQ QQ+LQ QQ    
Sbjct: 3897 LQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQ 3956

Query: 520  QHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQI 561
            Q  Q Q Q   +Q       + +    + SPQ   QQ Q Q+
Sbjct: 3957 QQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQ---QQQQQQV 3995



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 58/176 (32%), Positives = 69/176 (39%), Gaps = 41/176 (23%)

Query: 435  SVQTQQHQMQLQQQQQQQQQQMQQMQ-------QQQLQQHQMHQQIQQQMQQQHFQHHMQ 487
            +V  QQH   L  Q   +Q  M Q +        QQ Q    H+ +  Q QQQ  Q H Q
Sbjct: 3808 AVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQ-QQHQQ 3866

Query: 488  -------------------------------QHLQQQQQHLQQQINQQQLQQQLQQRLQL 516
                                           Q LQQQQQ  QQQ  QQQ QQQLQQ+ QL
Sbjct: 3867 QGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQL 3926

Query: 517  QQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQ 572
            QQ Q  Q Q Q   +Q      Q+      +   Q   QQ   Q Q Q Q  +L+Q
Sbjct: 3927 QQQQLQQQQQQQQLQQQQ--QQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQ 3980



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 81/303 (26%), Positives = 117/303 (38%), Gaps = 38/303 (12%)

Query: 298  EEQKQVYKRKTEAAK--KEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSS 355
            E+Q ++ K+  +  K  KE+   +A YR     +   +  + Q   +V     S + +  
Sbjct: 3569 EQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAV--LALSPSQSPR 3626

Query: 356  LLLNTP---LSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQ----IVTSVTIAANMP 408
            LL   P   L  HG     PQ         +   P  M LP       + T++       
Sbjct: 3627 LLTKLPGQLLPGHGL--QPPQGPPGGQAGGLRLTPGGMALPGQPGGPFLNTALAQQQQQQ 3684

Query: 409  SNIGA-PLISSMGTTMVGSAPSTQVSPSVQT-QQHQMQLQQQQQQQQQQMQQMQQ-QQLQ 465
             + GA  L    G    G+     + P  +  Q+ Q+QLQQQ+ Q  Q++QQ QQ QQ Q
Sbjct: 3685 HSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQ 3744

Query: 466  QHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQ-QLQQQL--------QQRLQL 516
            QH + Q   QQ QQQ       Q L  + Q L    + Q  L QQL        Q  L  
Sbjct: 3745 QHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQLSPQPPQGPQGMLGP 3804

Query: 517  QQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPA-------------SQQHQSQIQS 563
             Q+  +Q Q   +     P    + +    + SPQ A             +QQ Q Q Q 
Sbjct: 3805 AQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQH 3864

Query: 564  QTQ 566
            Q Q
Sbjct: 3865 QQQ 3867



 Score = 33.5 bits (75), Expect = 0.55
 Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 13/136 (9%)

Query: 428  PSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQ 487
            P   + P+V   + Q+Q    +  Q + +   QQQQLQ   M +Q+QQ   Q   Q    
Sbjct: 4186 PGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQ--SQAVRQTPPY 4243

Query: 488  QHLQQQQQHLQQQINQQQLQQQL-----QQRLQLQQLQHMQHQSQPSPRQHSPVASQITS 542
            Q    Q   LQ  +     Q QL      Q   LQ+L        P PR  +P  +  T 
Sbjct: 4244 QEPGTQTSPLQGLLG---CQPQLGGFPGPQTGPLQELGAGPRPQGP-PRLPAPPGALSTG 4299

Query: 543  PI--PAIGSPQPASQQ 556
            P+  P   +P P+S Q
Sbjct: 4300 PVLGPVHPTPPPSSPQ 4315



 Score = 33.1 bits (74), Expect = 0.71
 Identities = 49/170 (28%), Positives = 66/170 (38%), Gaps = 28/170 (16%)

Query: 416  ISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQ--I 473
            +  M +++V S     +   ++ ++ ++Q +QQ   Q Q  QQ QQQQ QQH +      
Sbjct: 3233 LDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQQ-QQHSLLSAPGP 3291

Query: 474  QQQMQQQHFQHHMQQHLQQQQQHL-----------QQQINQQQLQQQLQQRL-----QLQ 517
             Q M   H          QQQ  L           Q  +  Q     LQQRL      + 
Sbjct: 3292 AQAMSLPHEGSSPSLAGSQQQLSLGLAGARQPGLPQPLMPTQPPAHALQQRLAPSMAMVS 3351

Query: 518  QLQHM---QHQSQPS--PRQHS-PVASQI---TSPIPAIGSPQPASQQHQ 558
               HM   QH  Q    P+Q S PV SQ    T P      PQ  + Q Q
Sbjct: 3352 NQGHMLSGQHGGQAGLVPQQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQ 3401



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 6/63 (9%)

Query: 434  PSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQ 493
            P    ++ ++  +QQ + Q+Q  Q  +QQ+   + M +   +Q QQQ  Q       QQQ
Sbjct: 3557 PEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQ------QQQ 3610

Query: 494  QQH 496
            QQH
Sbjct: 3611 QQH 3613



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 21/59 (35%), Positives = 26/59 (44%), Gaps = 9/59 (15%)

Query: 65  EIPPITPPPESDP-------ALGMPDVLLPFQALSDPL--PSQGSEFTPQFPPQSLDLP 114
           E  P++PPPES P        L  P+   P  AL  PL  P + S  +P F    L  P
Sbjct: 499 EESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPP 557



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 49/218 (22%), Positives = 76/218 (34%), Gaps = 40/218 (18%)

Query: 65  EIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITISRN--- 121
           E  P++PPPE  P    P+         D   S   E +P  PP    L S+ +  +   
Sbjct: 667 EESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLL 726

Query: 122 -LVEQDGVL-HSSGLHMD--QSHTQVSQYRQDPSLIMRS-IVHMTDAARSGVMPPAQLTT 176
            L E+  +   S G H+        +S   ++P L  ++   H++         P     
Sbjct: 727 PLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEE----PCLCAV 782

Query: 177 INQSQLSAQLGLNLGGASMPHTSPSP-----------------PASKSATPSPSSSINEE 219
             +  LS Q       A  PH SP P                 P     +P P  S    
Sbjct: 783 PEEPHLSPQ-------AEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSP 835

Query: 220 DADE--ANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEP 255
            ++E   +    E   +P+  K P +P  + +K P EP
Sbjct: 836 QSEEPCLSPRPEESHLSPELEKPPLSP--RPEKPPEEP 871



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 18/52 (34%), Positives = 26/52 (50%), Gaps = 6/52 (11%)

Query: 430  TQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQH 481
            T+    +Q Q  Q++ QQ++        + +QQQ QQ       QQQ QQQH
Sbjct: 3568 TEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQ------QQQQQQQH 3613


>gi|110347429 mediator complex subunit 12 [Homo sapiens]
          Length = 2177

 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 58/143 (40%), Positives = 72/143 (50%), Gaps = 4/143 (2%)

Query: 414  PLISSM----GTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQM 469
            P+IS+M       +     ST + P  Q QQ Q Q QQQQQQQQQQ QQ QQ  ++Q Q 
Sbjct: 2025 PMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQ 2084

Query: 470  HQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPS 529
             Q ++QQ QQQ  Q   QQ  QQQQQ  QQQ  QQQ QQ    + Q Q     Q Q    
Sbjct: 2085 QQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQ 2144

Query: 530  PRQHSPVASQITSPIPAIGSPQP 552
             +Q    A+ +      + + QP
Sbjct: 2145 TQQQQQTAALVRQLQQQLSNTQP 2167



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 55/139 (39%), Positives = 63/139 (45%), Gaps = 1/139 (0%)

Query: 389  TMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQ 448
            T R     +  +  I+   P +          T ++      Q     Q QQ Q Q QQQ
Sbjct: 2013 TQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQ 2072

Query: 449  QQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQ 508
            QQQQ    QQ QQQ L+Q Q  QQ QQQ QQQ  Q   QQ  QQ QQ  QQQ    Q Q 
Sbjct: 2073 QQQQYHIRQQQQQQILRQQQQQQQ-QQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQP 2131

Query: 509  QLQQRLQLQQLQHMQHQSQ 527
            Q Q + Q Q LQ  Q Q Q
Sbjct: 2132 QSQPQFQRQGLQQTQQQQQ 2150



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 44/172 (25%), Positives = 59/172 (34%), Gaps = 15/172 (8%)

Query: 414  PLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQI 473
            P +S +G         T V PS  +Q +Q              + +QQ+      +HQQ 
Sbjct: 1946 PYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRP--SGYVHQQA 2003

Query: 474  QQQ----MQQQHFQHHMQQHLQQ-------QQQHLQQQINQQQL--QQQLQQRLQLQQLQ 520
                      Q F H   Q             Q +Q  +    +  +QQ QQ+ Q QQ Q
Sbjct: 2004 PTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQ 2063

Query: 521  HMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQ 572
              Q Q Q   +Q   +  Q    I      Q   QQ Q Q Q Q Q Q   Q
Sbjct: 2064 QQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQ 2115



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 64/243 (26%), Positives = 88/243 (36%), Gaps = 60/243 (24%)

Query: 373  QTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQV 432
            Q L    PR    +P+  RLPM ++ T  T    +P+ +         T ++G  PS+  
Sbjct: 1846 QPLPAGGPRVDPYRPV--RLPMQKLPTRPTYPGVLPTTM---------TGVMGLEPSSYK 1894

Query: 433  SPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQ-------------- 478
            + SV  QQ     Q Q+ +QQ Q  Q    Q   HQM       +Q              
Sbjct: 1895 T-SVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGL 1953

Query: 479  QQH-------------FQHHMQQH------LQQQQQHLQQQINQQQLQQQLQQRLQLQQL 519
            QQH              Q +   H      L    +HLQQ+ +    QQ       L   
Sbjct: 1954 QQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTST 2013

Query: 520  QHMQHQSQPSPRQHSPVASQITSPIPAIG----------SPQPASQQHQSQIQSQTQTQV 569
            Q   HQ+     Q +P+ S +T P+ A G           P+   QQ Q Q Q Q Q Q 
Sbjct: 2014 QRFSHQT----LQQTPMISTMT-PMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQ 2068

Query: 570  LSQ 572
              Q
Sbjct: 2069 QQQ 2071


>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
          Length = 715

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 67/174 (38%), Positives = 89/174 (51%), Gaps = 18/174 (10%)

Query: 362 LSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAP-----LI 416
           L Q  +   SP++  +  P  +   P+++ +   Q++T   +   +   + +P     L+
Sbjct: 66  LQQQTSGLKSPKSSDKQRPLQV---PVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALL 122

Query: 417 SSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQ 476
                 M+      Q+    + QQ Q+ LQ  QQQQQQQ QQ QQQQ QQ Q  QQ QQQ
Sbjct: 123 QQQQAVML---QQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 179

Query: 477 MQQQHFQHHMQQH------LQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQH 524
            QQQ  Q   QQH       QQQQQ  QQQ+  QQL  Q QQ LQ+QQLQ  QH
Sbjct: 180 QQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQ-QQLLQMQQLQQQQH 232



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 57/146 (39%), Positives = 72/146 (49%), Gaps = 13/146 (8%)

Query: 432 VSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQ----LQQHQMHQQIQQQMQQQHFQ--HH 485
           ++P V T Q   Q+ QQQ    QQ+Q + QQQ    LQQ Q+ +  ++Q +Q H Q    
Sbjct: 94  MTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQ 153

Query: 486 MQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQH-------QSQPSPRQHSPVAS 538
            QQ  QQQQQ  QQQ  QQQ QQQ QQ+ Q QQ Q  QH       Q Q   +Q    A 
Sbjct: 154 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQ 213

Query: 539 QITSPIPAIGSPQPASQQHQSQIQSQ 564
           Q+      +   Q   QQH   +Q Q
Sbjct: 214 QLVFQQQLLQMQQLQQQQHLLSLQRQ 239



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 50/102 (49%), Positives = 56/102 (54%), Gaps = 3/102 (2%)

Query: 437 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 496
           Q QQ Q Q QQQQQQQQQQ QQ QQQQ QQ Q  Q   +Q ++Q  Q   QQ L  QQ  
Sbjct: 157 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLV 216

Query: 497 LQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVAS 538
            QQQ+ Q    QQLQQ+  L  LQ     S P  +   PV S
Sbjct: 217 FQQQLLQ---MQQLQQQQHLLSLQRQGLISIPPGQAALPVQS 255



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 51/145 (35%), Positives = 65/145 (44%), Gaps = 16/145 (11%)

Query: 432 VSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQ 491
           VS ++ T Q     Q QQ  QQQ +   Q Q L Q Q    +QQQ  Q+ ++       Q
Sbjct: 89  VSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKK------Q 142

Query: 492 QQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQ 551
           Q+Q HLQ    QQQ QQQ QQ+ Q QQ Q  Q Q Q   +Q      Q            
Sbjct: 143 QEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ----------QH 192

Query: 552 PASQQHQSQIQSQTQTQVLSQVSIF 576
           P  Q  + Q Q Q Q Q+ +Q  +F
Sbjct: 193 PGKQAKEQQQQQQQQQQLAAQQLVF 217



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 56/188 (29%), Positives = 73/188 (38%), Gaps = 12/188 (6%)

Query: 394 MNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQ 453
           M +  T     ++M  N  + L S +         S   S  V T +  + LQQQQ  Q 
Sbjct: 2   MQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVE-LLHLQQQQALQA 60

Query: 454 QQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHL----QQQQQHLQQQI-NQQQLQQ 508
            +   +QQQ           +Q+  Q      M        QQ QQ LQQQ+ + QQLQ 
Sbjct: 61  ARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQA 120

Query: 509 QLQQR----LQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQ 564
            LQQ+    LQ QQLQ    + Q   + H  +  Q           Q   QQ Q Q Q Q
Sbjct: 121 LLQQQQAVMLQQQQLQEFYKKQQ--EQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQ 178

Query: 565 TQTQVLSQ 572
            Q Q   Q
Sbjct: 179 QQQQQQQQ 186



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 23/47 (48%), Positives = 25/47 (53%)

Query: 428 PSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQ 474
           P  Q     Q QQ Q QL  QQ   QQQ+ QMQQ Q QQH +  Q Q
Sbjct: 193 PGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQ 239


>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
          Length = 740

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 81/219 (36%), Positives = 105/219 (47%), Gaps = 28/219 (12%)

Query: 317 KALAAYRASLVSKAAA-----ESAEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSAS 371
           +AL A R  L+ +  +     +S++ Q  R +Q+ L  T L      +     H T  A 
Sbjct: 56  QALQAARQLLLQQQTSGLKSPKSSDKQ--RPLQELLPETKLCICGHSSGDGHPHNTF-AV 112

Query: 372 PQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQ 431
           P ++    P+ I P+       M QI+    ++   P  + A L       +       Q
Sbjct: 113 PVSVAMMTPQVITPQQ------MQQILQQQVLS---PQQLQALLQQQQAVML----QQQQ 159

Query: 432 VSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQH-- 489
           +    + QQ Q+ LQ  QQQQQQQ QQ QQQQ QQ Q  QQ QQQ QQQ  Q   QQH  
Sbjct: 160 LQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPG 219

Query: 490 ----LQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQH 524
                QQQQQ  QQQ+  QQL  Q QQ LQ+QQLQ  QH
Sbjct: 220 KQAKEQQQQQQQQQQLAAQQLVFQ-QQLLQMQQLQQQQH 257



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 73/220 (33%), Positives = 96/220 (43%), Gaps = 24/220 (10%)

Query: 362 LSQHGTVSASPQTLQQSLPRSI-APKPLTMRLPMNQIVTSVTIA-ANMPSNIGAPLISSM 419
           L Q   + A+ Q L Q     + +PK    + P+ +++    +      S  G P     
Sbjct: 52  LQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQELLPETKLCICGHSSGDGHP----- 106

Query: 420 GTTMVGSAPSTQVSPSVQTQQHQMQLQQQQ----QQ-----QQQQMQQMQQQQLQ----- 465
             T         ++P V T Q   Q+ QQQ    QQ     QQQQ   +QQQQLQ     
Sbjct: 107 HNTFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKK 166

Query: 466 -QHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQH 524
            Q Q+H Q+ QQ QQQ  Q   QQ  QQQQQ  QQQ  QQQ QQQ QQ+ Q    +  + 
Sbjct: 167 QQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQ--QQQQQQQQQQQQQQHPGKQAKE 224

Query: 525 QSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQ 564
           Q Q   +Q    A Q+      +   Q   QQH   +Q Q
Sbjct: 225 QQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQ 264



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 50/102 (49%), Positives = 56/102 (54%), Gaps = 3/102 (2%)

Query: 437 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 496
           Q QQ Q Q QQQQQQQQQQ QQ QQQQ QQ Q  Q   +Q ++Q  Q   QQ L  QQ  
Sbjct: 182 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLV 241

Query: 497 LQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVAS 538
            QQQ+ Q    QQLQQ+  L  LQ     S P  +   PV S
Sbjct: 242 FQQQLLQ---MQQLQQQQHLLSLQRQGLISIPPGQAALPVQS 280


>gi|93141033 PAX interacting protein 1 [Homo sapiens]
          Length = 1069

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 112/393 (28%), Positives = 154/393 (39%), Gaps = 67/393 (17%)

Query: 215 SINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIK 274
           S NE   DE +     +  +P SG +  +PK   +K   E     S+      D+    +
Sbjct: 208 SQNEGSTDEKSSPASSQEGSP-SGDQQFSPKSNTEKSKGELMFDDSS------DSSPEKQ 260

Query: 275 GQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAES 334
            +N N T  EV ++ A+             KR+    K+  L  L A    +        
Sbjct: 261 ERNLNWTPAEVPQLAAA-------------KRRLPQGKEPGLINLCANVPPVPGNILPPE 307

Query: 335 AEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPM 394
                + + Q   +S         +  +     ++ +    Q + P ++A    T+  P 
Sbjct: 308 VRGNLMAAGQNLQSSERSEMIATWSPAVRTLRNITNNADIQQMNRPSNVAHILQTLSAPT 367

Query: 395 NQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQ---------MQL 445
             +   V  +    +N  A L S +  T        Q     Q QQH          MQL
Sbjct: 368 KNLEQQVNHSQQGHTNANAVLFSQVKVTPETHMLQQQQQAQQQQQQHPVLHLQPQQIMQL 427

Query: 446 QQQQQQQ---------------QQQMQQMQ-------QQQLQ--QHQMH--QQI---QQQ 476
           QQQQQQQ               QQQ QQ Q       QQQLQ  Q Q+H  QQ+   QQQ
Sbjct: 428 QQQQQQQISQQPYPQQPPHPFSQQQQQQQQAHPHQFSQQQLQFPQQQLHPPQQLHRPQQQ 487

Query: 477 MQQQHFQHHMQQHLQQQQQH--LQQQINQQQ-----LQQQLQQRLQLQQLQ--HMQHQSQ 527
           +Q    QH +QQ   Q QQH   QQQ+ Q Q     LQQQ QQ++Q QQLQ  H Q Q Q
Sbjct: 488 LQPFQQQHALQQQFHQLQQHQLQQQQLAQLQQQHSLLQQQQQQQIQQQQLQRMHQQQQQQ 547

Query: 528 PSPRQHSPVASQITSPIPAIGSPQPASQQHQSQ 560
               Q +P  SQ +  +     PQ   QQ Q Q
Sbjct: 548 QMQSQTAPHLSQTSQALQHQVPPQQPPQQQQQQ 580



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 57/137 (41%), Positives = 72/137 (52%), Gaps = 18/137 (13%)

Query: 428 PSTQVSPSVQTQQHQMQLQ--QQQQQQQQQMQQMQQQQLQQHQM------HQQIQQQMQQ 479
           P  Q+ P  Q  + Q QLQ  QQQ   QQQ  Q+QQ QLQQ Q+      H  +QQQ QQ
Sbjct: 471 PQQQLHPPQQLHRPQQQLQPFQQQHALQQQFHQLQQHQLQQQQLAQLQQQHSLLQQQQQQ 530

Query: 480 QHFQHHMQQ-HLQQQQQHLQQQI--NQQQLQQQLQQRLQLQQLQHMQHQSQP--SPRQHS 534
           Q  Q  +Q+ H QQQQQ +Q Q   +  Q  Q LQ ++  QQ    Q Q QP  SP+QH 
Sbjct: 531 QIQQQQLQRMHQQQQQQQMQSQTAPHLSQTSQALQHQVPPQQPPQQQQQQQPPPSPQQH- 589

Query: 535 PVASQITSPIPAIGSPQ 551
               Q+    PA+  P+
Sbjct: 590 ----QLFGHDPAVEIPE 602



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 55/132 (41%), Positives = 63/132 (47%), Gaps = 15/132 (11%)

Query: 439 QQHQMQLQQQQQQ---------QQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQH 489
           Q  Q QLQ  QQQ          QQQ+Q  QQQ   Q Q HQ  Q Q+QQQ      QQH
Sbjct: 462 QFSQQQLQFPQQQLHPPQQLHRPQQQLQPFQQQHALQQQFHQLQQHQLQQQQLAQLQQQH 521

Query: 490 ---LQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPA 546
               QQQQQ +QQQ  Q+  QQQ QQ++Q Q   H+   SQ    Q  P   Q       
Sbjct: 522 SLLQQQQQQQIQQQQLQRMHQQQQQQQMQSQTAPHLSQTSQALQHQVPP---QQPPQQQQ 578

Query: 547 IGSPQPASQQHQ 558
              P P+ QQHQ
Sbjct: 579 QQQPPPSPQQHQ 590



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 2/53 (3%)

Query: 426 SAPSTQVSPSVQTQQHQMQLQQQQQQQQQQM--QQMQQQQLQQHQMHQQIQQQ 476
           S  +  +S + Q  QHQ+  QQ  QQQQQQ      QQ QL  H    +I ++
Sbjct: 551 SQTAPHLSQTSQALQHQVPPQQPPQQQQQQQPPPSPQQHQLFGHDPAVEIPEE 603


>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
          Length = 623

 Score = 92.8 bits (229), Expect = 8e-19
 Identities = 56/100 (56%), Positives = 61/100 (61%), Gaps = 7/100 (7%)

Query: 431 QVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQH- 489
           Q+    + QQ Q+ LQ  QQQQQQQ QQ QQQQ QQ Q  QQ QQQ QQQ  Q   QQH 
Sbjct: 42  QLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHP 101

Query: 490 -----LQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQH 524
                 QQQQQ  QQQ+  QQL  Q QQ LQ+QQLQ  QH
Sbjct: 102 GKQAKEQQQQQQQQQQLAAQQLVFQ-QQLLQMQQLQQQQH 140



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 53/100 (53%), Positives = 58/100 (58%), Gaps = 13/100 (13%)

Query: 437 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 496
           Q Q H   LQQQQQQQQQQ QQ QQQQ QQ Q  QQ QQQ QQQ          QQQQQH
Sbjct: 51  QEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ----------QQQQQH 100

Query: 497 LQQQINQQQLQQQLQQRLQLQQL---QHMQHQSQPSPRQH 533
             +Q  +QQ QQQ QQ+L  QQL   Q +    Q   +QH
Sbjct: 101 PGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQH 140



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 57/146 (39%), Positives = 72/146 (49%), Gaps = 13/146 (8%)

Query: 432 VSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQ----LQQHQMHQQIQQQMQQQHFQ--HH 485
           ++P V T Q   Q+ QQQ    QQ+Q + QQQ    LQQ Q+ +  ++Q +Q H Q    
Sbjct: 2   MTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQ 61

Query: 486 MQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQH-------QSQPSPRQHSPVAS 538
            QQ  QQQQQ  QQQ  QQQ QQQ QQ+ Q QQ Q  QH       Q Q   +Q    A 
Sbjct: 62  QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQ 121

Query: 539 QITSPIPAIGSPQPASQQHQSQIQSQ 564
           Q+      +   Q   QQH   +Q Q
Sbjct: 122 QLVFQQQLLQMQQLQQQQHLLSLQRQ 147



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 50/102 (49%), Positives = 56/102 (54%), Gaps = 3/102 (2%)

Query: 437 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 496
           Q QQ Q Q QQQQQQQQQQ QQ QQQQ QQ Q  Q   +Q ++Q  Q   QQ L  QQ  
Sbjct: 65  QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLV 124

Query: 497 LQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVAS 538
            QQQ+ Q    QQLQQ+  L  LQ     S P  +   PV S
Sbjct: 125 FQQQLLQ---MQQLQQQQHLLSLQRQGLISIPPGQAALPVQS 163



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 38/101 (37%), Positives = 45/101 (44%), Gaps = 14/101 (13%)

Query: 471 QQIQQQMQQQHFQHHMQQHLQQQQQHL---QQQINQQQLQQQLQQRLQLQQLQHMQHQSQ 527
           QQ+QQ +QQQ       Q L QQQQ +   QQQ+ +   +QQ Q  LQL Q Q  Q Q Q
Sbjct: 10  QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQ 69

Query: 528 PSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQ 568
              +Q      Q           Q   QQ Q Q Q Q Q Q
Sbjct: 70  QQQQQQQQQQQQ-----------QQQQQQQQQQQQQQQQQQ 99



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 23/47 (48%), Positives = 25/47 (53%)

Query: 428 PSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQ 474
           P  Q     Q QQ Q QL  QQ   QQQ+ QMQQ Q QQH +  Q Q
Sbjct: 101 PGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQ 147


>gi|221139761 zinc finger protein 853 [Homo sapiens]
          Length = 659

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 63/176 (35%), Positives = 84/176 (47%), Gaps = 11/176 (6%)

Query: 408 PSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQH 467
           P   G   +S +      S    ++ P +Q    Q QLQ QQ Q+QQ++QQ Q+Q   Q 
Sbjct: 122 PQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQ 181

Query: 468 QMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQ--------QINQQQLQQQLQQRLQLQQL 519
              QQ+ QQ +Q   Q   QQ LQQQQ+ LQQ        Q+ QQQ QQQ +Q  Q QQL
Sbjct: 182 AQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQL 241

Query: 520 QHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQ---QHQSQIQSQTQTQVLSQ 572
             +Q Q Q   +      +Q+   +      Q   Q   Q Q Q+Q Q Q Q+L Q
Sbjct: 242 LLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQ 297



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 57/146 (39%), Positives = 78/146 (53%), Gaps = 9/146 (6%)

Query: 431 QVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHL 490
           Q    +Q QQ Q+Q QQ Q+QQ  Q Q+  QQQ+Q+ Q+ QQ Q+Q+QQQ      +Q  
Sbjct: 165 QEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQ 224

Query: 491 QQQQQHLQQQINQQQ----LQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPA 546
           QQQ Q  Q+Q+ QQQ    LQQQ Q + QL Q Q  Q Q Q   +Q + +  Q+      
Sbjct: 225 QQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQL-----L 279

Query: 547 IGSPQPASQQHQSQIQSQTQTQVLSQ 572
           +   +   QQ Q Q+  Q Q Q+  Q
Sbjct: 280 LQQQEQLQQQQQQQLLQQQQEQLQQQ 305



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 66/150 (44%), Positives = 77/150 (51%), Gaps = 16/150 (10%)

Query: 431 QVSPSVQTQQHQMQLQQQ---QQQQQQQMQQMQQQQLQQHQMHQ--------QIQQQMQQ 479
           QV      QQ Q QLQQQ   QQQ+Q Q QQ QQQQ Q  Q  Q        Q+QQQ+ Q
Sbjct: 197 QVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQ 256

Query: 480 QHFQHHMQQHLQQQQQHLQQQI---NQQQLQQQLQQR-LQLQQLQHMQHQSQPSPRQHSP 535
           Q      QQ L+QQQ  LQQQ+    Q+QLQQQ QQ+ LQ QQ Q  Q Q QP P +   
Sbjct: 257 QQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316

Query: 536 VASQITSPIPA-IGSPQPASQQHQSQIQSQ 564
                   +P  +GS Q   QQ Q   + Q
Sbjct: 317 EEEVELELMPVDLGSEQELEQQRQELERQQ 346



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 55/163 (33%), Positives = 81/163 (49%), Gaps = 24/163 (14%)

Query: 426 SAP--STQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQ 483
           SAP  +++++   +  Q ++QLQQ +QQ + Q QQ Q +QLQQ Q H ++QQQ QQ   Q
Sbjct: 70  SAPVGASEIAEETRPGQRELQLQQLEQQPEPQ-QQPQHEQLQQPQPHLELQQQPQQDGQQ 128

Query: 484 -------------HHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSP 530
                        HH +   + Q  H QQQ+  QQ+Q+Q + + Q +QLQ  Q Q Q   
Sbjct: 129 QLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVL 188

Query: 531 RQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQV 573
           +Q   +  Q+          Q   QQ Q Q+Q Q   Q   Q+
Sbjct: 189 QQQEQLQQQV--------QEQQLLQQQQEQLQQQQLLQQQEQL 223



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 61/159 (38%), Positives = 81/159 (50%), Gaps = 24/159 (15%)

Query: 428 PSTQVSPS-VQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQM--HQQIQQQMQQQHFQH 484
           P  Q  P   Q QQ Q  L+ QQQ QQ   QQ+ Q Q ++HQ   HQ+++ ++Q  H Q 
Sbjct: 98  PEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQ 157

Query: 485 HMQ-------QHLQQQQQHLQ-QQINQQQL---QQQLQQRLQLQQLQHMQHQSQPSPRQH 533
            +Q       Q LQQQQ+ LQ QQ  +QQ+   Q+QLQQ++Q QQL   Q Q Q   +Q 
Sbjct: 158 QLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLL-QQQQEQLQQQQL 216

Query: 534 SPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQ 572
                Q+          Q   QQ Q Q+Q Q Q  +L Q
Sbjct: 217 LQQQEQL---------QQQQFQQQQEQLQQQQQLLLLQQ 246



 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 45/136 (33%), Positives = 80/136 (58%), Gaps = 5/136 (3%)

Query: 439 QQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHM--QQHLQQQQQH 496
           QQ Q+Q QQQQQ  QQQ +Q+QQQQLQ   +  + +++++ +     +  +Q L+QQ+Q 
Sbjct: 282 QQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQE 341

Query: 497 L--QQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPAS 554
           L  QQ++ +QQ Q+QLQ +LQ ++LQ ++ Q +   +Q      Q+      +G+ Q   
Sbjct: 342 LERQQELERQQEQRQLQLKLQ-EELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEV 400

Query: 555 QQHQSQIQSQTQTQVL 570
           Q   + +Q + Q +++
Sbjct: 401 QLELTPVQPELQLELV 416



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 37/105 (35%), Positives = 61/105 (58%), Gaps = 8/105 (7%)

Query: 431 QVSPSVQTQQHQMQLQQQQQQ-QQQQMQQMQQQQLQQHQMHQQI-------QQQMQQQHF 482
           Q    +Q QQ Q  LQQQQ+Q QQQQ+Q    +  ++ ++  ++       +Q+++QQ  
Sbjct: 281 QQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQ 340

Query: 483 QHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQ 527
           +   QQ L++QQ+  Q Q+  Q+  QQL+Q+L+ QQ Q  Q + Q
Sbjct: 341 ELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQ 385



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 4/89 (4%)

Query: 424 VGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQ 483
           +GS    +       +Q +++ QQ+Q+Q Q ++Q+ + QQL+Q Q+ QQ QQQ++QQ  Q
Sbjct: 329 LGSEQELEQQRQELERQQELERQQEQRQLQLKLQE-ELQQLEQ-QLEQQ-QQQLEQQEVQ 385

Query: 484 HHMQQ-HLQQQQQHLQQQINQQQLQQQLQ 511
             +    L  QQQ +Q ++   Q + QL+
Sbjct: 386 LELTPVELGAQQQEVQLELTPVQPELQLE 414



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 21/98 (21%), Positives = 42/98 (42%), Gaps = 6/98 (6%)

Query: 478 QQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVA 537
           + Q  +   +++   Q+  +   +   ++ ++ +   +  QLQ ++ Q +P   Q  P  
Sbjct: 50  ESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEP---QQQPQH 106

Query: 538 SQITSPIPAI---GSPQPASQQHQSQIQSQTQTQVLSQ 572
            Q+  P P +     PQ   QQ  SQ+Q +    V  Q
Sbjct: 107 EQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQ 144


>gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]
          Length = 1161

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 51/124 (41%), Positives = 59/124 (47%), Gaps = 16/124 (12%)

Query: 439 QQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQ 498
           QQ Q Q QQQQQQQQQQ QQ QQQQ   H  H  + Q    Q +QH  QQ    QQQ L 
Sbjct: 461 QQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLM 520

Query: 499 QQINQ------------QQLQQQLQQRLQLQQLQHMQHQSQP----SPRQHSPVASQITS 542
             + Q             Q QQ   Q+  L Q Q  Q Q+ P    SP++ SP     TS
Sbjct: 521 HSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTS 580

Query: 543 PIPA 546
            +PA
Sbjct: 581 SLPA 584



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 53/135 (39%), Positives = 62/135 (45%), Gaps = 10/135 (7%)

Query: 437 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 496
           Q QQ   +LQQ   Q +   QQ QQQQ QQ Q  QQ QQQ QQQ  QHH   H      H
Sbjct: 440 QLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHH-----HH 494

Query: 497 LQQQINQQQLQQ--QLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPI---PAIGSPQ 551
           L Q    QQ Q   Q QQ LQ Q L H  +Q QPS  Q+  +  Q          +   Q
Sbjct: 495 LLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQ 554

Query: 552 PASQQHQSQIQSQTQ 566
           P+ QQ   +  +  Q
Sbjct: 555 PSQQQASPEYLTSPQ 569


>gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]
          Length = 662

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 51/124 (41%), Positives = 59/124 (47%), Gaps = 16/124 (12%)

Query: 439 QQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQ 498
           QQ Q Q QQQQQQQQQQ QQ QQQQ   H  H  + Q    Q +QH  QQ    QQQ L 
Sbjct: 461 QQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLM 520

Query: 499 QQINQ------------QQLQQQLQQRLQLQQLQHMQHQSQP----SPRQHSPVASQITS 542
             + Q             Q QQ   Q+  L Q Q  Q Q+ P    SP++ SP     TS
Sbjct: 521 HSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTS 580

Query: 543 PIPA 546
            +PA
Sbjct: 581 SLPA 584



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 53/135 (39%), Positives = 62/135 (45%), Gaps = 10/135 (7%)

Query: 437 QTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQH 496
           Q QQ   +LQQ   Q +   QQ QQQQ QQ Q  QQ QQQ QQQ  QHH   H      H
Sbjct: 440 QLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHH-----HH 494

Query: 497 LQQQINQQQLQQ--QLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPI---PAIGSPQ 551
           L Q    QQ Q   Q QQ LQ Q L H  +Q QPS  Q+  +  Q          +   Q
Sbjct: 495 LLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQ 554

Query: 552 PASQQHQSQIQSQTQ 566
           P+ QQ   +  +  Q
Sbjct: 555 PSQQQASPEYLTSPQ 569


>gi|169202818 PREDICTED: similar to hCG1991922 [Homo sapiens]
          Length = 488

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 36/84 (42%), Positives = 56/84 (66%)

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PK   KKK KDPN P++P SA+ L+F +    IKG+ P  +FG+V+K +  MW++   + 
Sbjct: 217 PKGETKKKFKDPNAPKRPPSAFFLYFSEYGPKIKGERPGLSFGDVAKKLGEMWNNTAADD 276

Query: 301 KQVYKRKTEAAKKEYLKALAAYRA 324
           KQ Y++++   K++Y K +AAYRA
Sbjct: 277 KQPYEKRSAKLKEKYEKDIAAYRA 300


>gi|239749996 PREDICTED: similar to hCG1991922 [Homo sapiens]
          Length = 487

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 36/84 (42%), Positives = 56/84 (66%)

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PK   KKK KDPN P++P SA+ L+F +    IKG+ P  +FG+V+K +  MW++   + 
Sbjct: 217 PKGETKKKFKDPNAPKRPPSAFFLYFSEYGPKIKGERPGLSFGDVAKKLGEMWNNTAADD 276

Query: 301 KQVYKRKTEAAKKEYLKALAAYRA 324
           KQ Y++++   K++Y K +AAYRA
Sbjct: 277 KQPYEKRSAKLKEKYEKDIAAYRA 300


>gi|239744307 PREDICTED: similar to hCG1991922 [Homo sapiens]
          Length = 486

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 36/84 (42%), Positives = 56/84 (66%)

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PK   KKK KDPN P++P SA+ L+F +    IKG+ P  +FG+V+K +  MW++   + 
Sbjct: 217 PKGETKKKFKDPNAPKRPPSAFFLYFSEYGPKIKGERPGLSFGDVAKKLGEMWNNTAADD 276

Query: 301 KQVYKRKTEAAKKEYLKALAAYRA 324
           KQ Y++++   K++Y K +AAYRA
Sbjct: 277 KQPYEKRSAKLKEKYEKDIAAYRA 300


>gi|4504425 high-mobility group box 1 [Homo sapiens]
          Length = 215

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 36/84 (42%), Positives = 55/84 (65%)

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PK   KKK KDPN P++P SA+ LF  + +  IKG++P  + G+V+K +  MW++   + 
Sbjct: 81  PKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADD 140

Query: 301 KQVYKRKTEAAKKEYLKALAAYRA 324
           KQ Y++K    K++Y K +AAYRA
Sbjct: 141 KQPYEKKAAKLKEKYEKDIAAYRA 164



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 21/76 (27%), Positives = 41/76 (53%), Gaps = 2/76 (2%)

Query: 249 KKDPNEPQKPVSAYALFFRDTQAAIKGQNPNAT--FGEVSKIVASMWDSLGEEQKQVYKR 306
           K DP +P+  +S+YA F +  +   K ++P+A+  F E SK  +  W ++  ++K  ++ 
Sbjct: 3   KGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFED 62

Query: 307 KTEAAKKEYLKALAAY 322
             +A K  Y + +  Y
Sbjct: 63  MAKADKARYEREMKTY 78


>gi|4507241 structure specific recognition protein 1 [Homo sapiens]
          Length = 709

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 42/145 (28%), Positives = 77/145 (53%), Gaps = 1/145 (0%)

Query: 207 SATPSPSSSINEEDADEANRA-IGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALF 265
           +A+ S SS+  + D DE  R  + + + A D   + K  + KK KDPN P++P+SAY L+
Sbjct: 498 NASASSSSNEGDSDRDEKKRKQLKKAKMAKDRKSRKKPVEVKKGKDPNAPKRPMSAYMLW 557

Query: 266 FRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRAS 325
              ++  IK  +P  +  ++SK    +W  + +E+K+ + RK E A+++Y KA+  Y   
Sbjct: 558 LNASREKIKSDHPGISITDLSKKAGEIWKGMSKEKKEEWDRKAEDARRDYEKAMKEYEGG 617

Query: 326 LVSKAAAESAEAQTIRSVQQTLAST 350
               +  + ++ +    V+    ST
Sbjct: 618 RGESSKRDKSKKKKKVKVKMEKKST 642


>gi|56549696 E1A binding protein p400 [Homo sapiens]
          Length = 3122

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 75/270 (27%), Positives = 113/270 (41%), Gaps = 31/270 (11%)

Query: 337  AQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMN- 395
            A T +S+ + LAS     +L      +    V   P       P +  P  ++M      
Sbjct: 2607 AATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATTQGV 2666

Query: 396  QIVTSVTIAANMPSNIGAPLISSMGTT-MVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQ 454
            + VTSVT +A + +N+      +      V  A   Q+     T  H   L+QQQQQQQQ
Sbjct: 2667 RAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQ 2726

Query: 455  QMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQ--QINQQQLQQQLQQ 512
            Q QQ QQQQ QQ Q  QQ QQ       Q    Q   Q    ++   ++  + L +  +Q
Sbjct: 2727 QQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQ 2786

Query: 513  RLQL--------------QQLQHMQHQSQPSPRQHSPVASQITSPIP-------AIGSPQ 551
            +LQ+              Q    +Q Q+   P+Q SP  + +T+P P        + + Q
Sbjct: 2787 KLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVANLQ 2846

Query: 552  PA------SQQHQSQIQSQTQTQVLSQVSI 575
             A      + Q Q+Q Q QTQ    +QV++
Sbjct: 2847 VARLTRVPTSQLQAQGQMQTQAPQPAQVAL 2876



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 99/430 (23%), Positives = 157/430 (36%), Gaps = 68/430 (15%)

Query: 157  IVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSI 216
            ++ MT   RS  + P  L  +N  Q + +    L  + + +  P PP   ++  +     
Sbjct: 2430 LMKMTAGKRSPPIKP--LLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRA----- 2482

Query: 217  NEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQ 276
             E  A E      +++A   +  +P  P+ +    P +P  P+          Q    G 
Sbjct: 2483 -ERIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLP---------QPQAAGS 2532

Query: 277  NPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAE 336
             P A                G    Q   +     + + ++A A  + ++ +  +A    
Sbjct: 2533 QPPA----------------GPPAVQPQPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLA 2576

Query: 337  AQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQ 396
                 SV  T   T   S  ++   ++  G  +A+ Q++ + L   +AP  LT   P   
Sbjct: 2577 GTIKTSVTGTSMPTGAVSGNVIVNTIA--GVPAATFQSINKRLASPVAPGALTT--PGGS 2632

Query: 397  IVTSVTIAANMPSNIGAPLIS-----SMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQ 451
                V      P  +G+P  +     SM TT  G    T V+ S     +   +Q   + 
Sbjct: 2633 APAQVVHTQPPPRAVGSPATATPDLVSMATTQ-GVRAVTSVTASAVVTTNLTPVQTPARS 2691

Query: 452  QQQQMQQMQQQQLQ-------QHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQ----- 499
               Q+ Q    QL          Q+ +Q QQQ QQQ  Q   QQ  QQQQQ  QQ     
Sbjct: 2692 LVPQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTT 2751

Query: 500  -QINQQQLQQQLQQRLQL--------QQLQHMQHQSQPSPRQHSPVASQITSPIPA---- 546
             Q+   Q+Q Q Q   Q+        + L  MQ Q    P Q  P  +Q   P P     
Sbjct: 2752 SQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQMPPQPPPPQAQSAPPQPTAQVQ 2811

Query: 547  IGSPQPASQQ 556
            + + QP  QQ
Sbjct: 2812 VQTSQPPQQQ 2821



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 53/221 (23%), Positives = 89/221 (40%), Gaps = 9/221 (4%)

Query: 352  LTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNI 411
            LT + + N  +++   V  S Q   Q   ++ AP+P  + L    +V+      + P   
Sbjct: 2837 LTGTTVANLQVARLTRVPTS-QLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVT 2895

Query: 412  GAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQ 471
              P+ +  G ++    P      +V  Q   + +QQ  + +QQ +QQ +  Q Q  Q   
Sbjct: 2896 TLPM-NVAGISVAIGQPQKAAGQTVVAQP--VHMQQLLKLKQQAVQQQKAIQPQAAQGPA 2952

Query: 472  QIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPR 531
             +QQ++  Q       Q  Q+     Q  +  Q L   + Q  +L   Q +Q Q Q +  
Sbjct: 2953 AVQQKITAQQITTPGAQ--QKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVA-- 3008

Query: 532  QHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQ 572
               P   Q  +P+ +I     ASQQ   Q  + TQ     Q
Sbjct: 3009 -KLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAGQ 3048



 Score = 33.5 bits (75), Expect = 0.55
 Identities = 79/397 (19%), Positives = 143/397 (36%), Gaps = 73/397 (18%)

Query: 55   HTPSLGDEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLP 114
            H   +  ++ ++PP  PPP++  A   P   +  Q  S P   Q  + T    P+   L 
Sbjct: 2779 HLIKMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQT-SQPPQQQSPQLTTVTAPRPGALL 2837

Query: 115  SITISRNLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQL 174
            + T   NL  Q   L        Q+  Q+      P+ +  +   +     + V  P   
Sbjct: 2838 TGTTVANL--QVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVT 2895

Query: 175  TTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRA- 233
            T          L +N+ G S+    P   A ++    P     ++      +A+ +++A 
Sbjct: 2896 T----------LPMNVAGISVAIGQPQKAAGQTVVAQPVHM--QQLLKLKQQAVQQQKAI 2943

Query: 234  APDSGKKPKTPKKK----KKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIV 289
             P + + P   ++K    +   P   QK   AYA      Q A+K Q       +  K+ 
Sbjct: 2944 QPQAAQGPAAVQQKITAQQITTPGAQQK--VAYA-----AQPALKTQFLTTPISQAQKLA 2996

Query: 290  ASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLAS 349
             +      + Q Q+   K     ++     +  + +    +A++ A  QT+   Q T A 
Sbjct: 2997 GAQ-----QVQTQIQVAKLPQVVQQQTPVASIQQVA----SASQQASPQTVALTQATAAG 3047

Query: 350  TNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPS 409
                        +     V+A+ Q +QQ             +L   Q+VT+ +     P 
Sbjct: 3048 QQ----------VQMIPAVTATAQVVQQ-------------KLIQQQVVTTASAPLQTP- 3083

Query: 410  NIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQ 446
              GAP             P++  SPS   QQ ++Q++
Sbjct: 3084 --GAP--------NPAQVPASSDSPS---QQPKLQMR 3107


>gi|19923236 nuclear antigen Sp100 isoform 2 [Homo sapiens]
          Length = 879

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 39/102 (38%), Positives = 61/102 (59%), Gaps = 4/102 (3%)

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PK  KKKK KDPN P++P  A+ LF  + +  IKG++P  +  +V K +A MW++     
Sbjct: 755 PKGEKKKKFKDPNAPKRPPLAFFLFCSEYRPKIKGEHPGLSIDDVVKKLAGMWNNTAAAD 814

Query: 301 KQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRS 342
           KQ Y++K    K++Y K +AAYRA    K    SA+ + +++
Sbjct: 815 KQFYEKKAAKLKEKYKKDIAAYRA----KGKPNSAKKRVVKA 852


>gi|194688135 high-mobility group box 2 [Homo sapiens]
          Length = 209

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 37/90 (41%), Positives = 55/90 (61%)

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PK  KK KKKDPN P++P SA+ LF  + +  IK ++P  + G+ +K +  MW     + 
Sbjct: 81  PKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD 140

Query: 301 KQVYKRKTEAAKKEYLKALAAYRASLVSKA 330
           KQ Y++K    K++Y K +AAYRA   S+A
Sbjct: 141 KQPYEQKAAKLKEKYEKDIAAYRAKGKSEA 170



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/76 (26%), Positives = 42/76 (55%), Gaps = 2/76 (2%)

Query: 249 KKDPNEPQKPVSAYALFFRDTQAAIKGQNPNAT--FGEVSKIVASMWDSLGEEQKQVYKR 306
           K DPN+P+  +S+YA F +  +   K ++P+++  F E SK  +  W ++  ++K  ++ 
Sbjct: 3   KGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFED 62

Query: 307 KTEAAKKEYLKALAAY 322
             ++ K  Y + +  Y
Sbjct: 63  MAKSDKARYDREMKNY 78


>gi|194688133 high-mobility group box 2 [Homo sapiens]
          Length = 209

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 37/90 (41%), Positives = 55/90 (61%)

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PK  KK KKKDPN P++P SA+ LF  + +  IK ++P  + G+ +K +  MW     + 
Sbjct: 81  PKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD 140

Query: 301 KQVYKRKTEAAKKEYLKALAAYRASLVSKA 330
           KQ Y++K    K++Y K +AAYRA   S+A
Sbjct: 141 KQPYEQKAAKLKEKYEKDIAAYRAKGKSEA 170



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/76 (26%), Positives = 42/76 (55%), Gaps = 2/76 (2%)

Query: 249 KKDPNEPQKPVSAYALFFRDTQAAIKGQNPNAT--FGEVSKIVASMWDSLGEEQKQVYKR 306
           K DPN+P+  +S+YA F +  +   K ++P+++  F E SK  +  W ++  ++K  ++ 
Sbjct: 3   KGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFED 62

Query: 307 KTEAAKKEYLKALAAY 322
             ++ K  Y + +  Y
Sbjct: 63  MAKSDKARYDREMKNY 78


>gi|11321591 high-mobility group box 2 [Homo sapiens]
          Length = 209

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 37/90 (41%), Positives = 55/90 (61%)

Query: 241 PKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQ 300
           PK  KK KKKDPN P++P SA+ LF  + +  IK ++P  + G+ +K +  MW     + 
Sbjct: 81  PKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD 140

Query: 301 KQVYKRKTEAAKKEYLKALAAYRASLVSKA 330
           KQ Y++K    K++Y K +AAYRA   S+A
Sbjct: 141 KQPYEQKAAKLKEKYEKDIAAYRAKGKSEA 170



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/76 (26%), Positives = 42/76 (55%), Gaps = 2/76 (2%)

Query: 249 KKDPNEPQKPVSAYALFFRDTQAAIKGQNPNAT--FGEVSKIVASMWDSLGEEQKQVYKR 306
           K DPN+P+  +S+YA F +  +   K ++P+++  F E SK  +  W ++  ++K  ++ 
Sbjct: 3   KGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFED 62

Query: 307 KTEAAKKEYLKALAAY 322
             ++ K  Y + +  Y
Sbjct: 63  MAKSDKARYDREMKNY 78


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.122    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,015,551
Number of Sequences: 37866
Number of extensions: 1212906
Number of successful extensions: 34729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 583
Number of HSP's successfully gapped in prelim test: 708
Number of HSP's that attempted gapping in prelim test: 10946
Number of HSP's gapped (non-prelim): 9004
length of query: 576
length of database: 18,247,518
effective HSP length: 108
effective length of query: 468
effective length of database: 14,157,990
effective search space: 6625939320
effective search space used: 6625939320
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.