BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|205360977 LAG1 homolog, ceramide synthase 4 [Homo sapiens] (394 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|205360977 LAG1 homolog, ceramide synthase 4 [Homo sapiens] 816 0.0 gi|32455256 LAG1 longevity assurance 2 [Homo sapiens] 384 e-106 gi|31077094 LAG1 longevity assurance 2 [Homo sapiens] 384 e-106 gi|116235446 LAG1 longevity assurance homolog 3 [Homo sapiens] 345 4e-95 gi|22218345 LAG1 homolog, ceramide synthase 5 [Homo sapiens] 327 1e-89 gi|45007002 longevity assurance homolog 6 [Homo sapiens] 319 2e-87 gi|11641421 LAG1 homolog, ceramide synthase 1 isoform 1 [Homo sa... 110 2e-24 gi|38176296 LAG1 homolog, ceramide synthase 1 isoform 2 [Homo sa... 108 6e-24 gi|6912450 translocation-associated membrane protein 2 [Homo sap... 62 9e-10 gi|7657655 translocation associated membrane protein 1 [Homo sap... 56 5e-08 gi|145580602 translocation associated membrane protein 1-like 1 ... 55 8e-08 gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 35 0.090 gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 35 0.090 gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 35 0.090 gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 35 0.090 gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 35 0.090 gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 35 0.090 gi|224282187 HOP homeobox isoform a [Homo sapiens] 35 0.15 gi|224451023 HOP homeobox isoform b [Homo sapiens] 35 0.15 gi|21264589 HOP homeobox isoform b [Homo sapiens] 35 0.15 gi|21264587 HOP homeobox isoform b [Homo sapiens] 35 0.15 gi|219275578 SIX homeobox 2 [Homo sapiens] 32 0.76 gi|84626580 hypothetical protein LOC80178 [Homo sapiens] 32 0.76 gi|4885597 sine oculis homeobox homolog 3 [Homo sapiens] 32 1.3 gi|4505623 pre-B-cell leukemia homeobox 1 [Homo sapiens] 32 1.3 gi|27436887 pre-B-cell leukemia homeobox 2 [Homo sapiens] 32 1.3 gi|157074214 potassium channel, subfamily U, member 1 [Homo sapi... 32 1.3 gi|5174681 SIX homeobox 1 [Homo sapiens] 31 2.2 gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens] 31 2.2 gi|18860857 menin isoform 1 [Homo sapiens] 30 2.9 >gi|205360977 LAG1 homolog, ceramide synthase 4 [Homo sapiens] Length = 394 Score = 816 bits (2109), Expect = 0.0 Identities = 394/394 (100%), Positives = 394/394 (100%) Query: 1 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 60 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI Sbjct: 1 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 60 Query: 61 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 120 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR Sbjct: 61 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 120 Query: 121 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 180 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY Sbjct: 121 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 180 Query: 181 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 240 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD Sbjct: 181 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 240 Query: 241 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 300 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF Sbjct: 241 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 300 Query: 301 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 360 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL Sbjct: 301 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 360 Query: 361 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 394 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT Sbjct: 361 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 394 >gi|32455256 LAG1 longevity assurance 2 [Homo sapiens] Length = 380 Score = 384 bits (985), Expect = e-106 Identities = 184/374 (49%), Positives = 255/374 (68%), Gaps = 10/374 (2%) Query: 1 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 60 ML + ++FW +R WLP N+TW +LEDRDGRVY DL LPLAL+ L +R FE ++ Sbjct: 1 MLQTLYDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLPLALLFLIVRYFFELYV 60 Query: 61 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 120 PL+ L ++++TR + PNATLE +LT G +PK+ ++ LL+ Q GL+ +Q +RWFRR Sbjct: 61 ATPLAALLNIKEKTRLRAPPNATLEHFYLTSGKQPKQVEVELLSRQSGLSGRQVERWFRR 120 Query: 121 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 180 RRNQDRP L KKF EASWRF FYL +F+ G++V+ + W + W+ YP Q+ PS Y Sbjct: 121 RRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWFYDMKKVWEGYPIQSTIPSQY 180 Query: 181 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 240 W+Y++EL FY SLL + DVKRKDFKEQ+IHH +IL++FS+ AN +R G+L++ LHD Sbjct: 181 WYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYIRAGTLIMALHD 240 Query: 241 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 300 SSDYLLE+ KM NY ++ C+ +F++F+ VF TRLV+ P IL+ T + FF Sbjct: 241 SSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRLVILPFWILHCTLVYPLELYPAFF 300 Query: 301 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 360 GYYFFN ++ +LQLLH+FW+ LILRM + F+ G++ +D RSD EE++SSE AA Sbjct: 301 GYYFFNSMMGVLQLLHIFWAYLILRMAHKFI-TGKLVEDERSDREETESSEGEEAA---- 355 Query: 361 QLKNGAAGGPRPAP 374 A GG + P Sbjct: 356 -----AGGGAKSRP 364 >gi|31077094 LAG1 longevity assurance 2 [Homo sapiens] Length = 380 Score = 384 bits (985), Expect = e-106 Identities = 184/374 (49%), Positives = 255/374 (68%), Gaps = 10/374 (2%) Query: 1 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 60 ML + ++FW +R WLP N+TW +LEDRDGRVY DL LPLAL+ L +R FE ++ Sbjct: 1 MLQTLYDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLPLALLFLIVRYFFELYV 60 Query: 61 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 120 PL+ L ++++TR + PNATLE +LT G +PK+ ++ LL+ Q GL+ +Q +RWFRR Sbjct: 61 ATPLAALLNIKEKTRLRAPPNATLEHFYLTSGKQPKQVEVELLSRQSGLSGRQVERWFRR 120 Query: 121 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 180 RRNQDRP L KKF EASWRF FYL +F+ G++V+ + W + W+ YP Q+ PS Y Sbjct: 121 RRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWFYDMKKVWEGYPIQSTIPSQY 180 Query: 181 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 240 W+Y++EL FY SLL + DVKRKDFKEQ+IHH +IL++FS+ AN +R G+L++ LHD Sbjct: 181 WYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYIRAGTLIMALHD 240 Query: 241 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 300 SSDYLLE+ KM NY ++ C+ +F++F+ VF TRLV+ P IL+ T + FF Sbjct: 241 SSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRLVILPFWILHCTLVYPLELYPAFF 300 Query: 301 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 360 GYYFFN ++ +LQLLH+FW+ LILRM + F+ G++ +D RSD EE++SSE AA Sbjct: 301 GYYFFNSMMGVLQLLHIFWAYLILRMAHKFI-TGKLVEDERSDREETESSEGEEAA---- 355 Query: 361 QLKNGAAGGPRPAP 374 A GG + P Sbjct: 356 -----AGGGAKSRP 364 >gi|116235446 LAG1 longevity assurance homolog 3 [Homo sapiens] Length = 383 Score = 345 bits (885), Expect = 4e-95 Identities = 175/372 (47%), Positives = 235/372 (63%), Gaps = 11/372 (2%) Query: 1 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 60 M +F EWFW +RFWLPP + W++LED DG V+ P L +P A +LL +R FE+F+ Sbjct: 1 MFWTFKEWFWLERFWLPPTIKWSDLEDHDGLVFVKPSHLYVTIPYAFLLLIIRRVFEKFV 60 Query: 61 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 120 PL++ G+++ T R+V PN LE F +P + + LA +C LT +Q +RWFR Sbjct: 61 ASPLAKSFGIKE-TVRKVTPNTVLENFFKHSTRQPLQTDIYGLAKKCNLTERQVERWFRS 119 Query: 121 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 180 RRNQ+RP KKF EA WRF FYL V G++ LY + WL+ W+ YP Q L PS Y Sbjct: 120 RRNQERPSRLKKFQEACWRFAFYLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQY 179 Query: 181 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 240 W+Y+LE+ FY SLL RL FDVKRKDF +IHH A+ LM+FS+ AN +R G+LV+++HD Sbjct: 180 WYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHD 239 Query: 241 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 300 +D LE+ KM +Y + Q C+ LF IFS +FF +RL++FP ILY T + + PFF Sbjct: 240 VADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFF 299 Query: 301 GYYFFNGLLMLLQLLHVFWSCLILRMLYS--FMKKGQMEKDIRSD-----VEESDSSEEA 353 Y F N LM+LQ+LH++W IL+ML FMK Q D+RSD EE + EEA Sbjct: 300 SYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMKSIQ---DVRSDDEDYEEEEEEEEEEA 356 Query: 354 AAAQEPLQLKNG 365 +E LKNG Sbjct: 357 TKGKEMDCLKNG 368 >gi|22218345 LAG1 homolog, ceramide synthase 5 [Homo sapiens] Length = 392 Score = 327 bits (838), Expect = 1e-89 Identities = 159/346 (45%), Positives = 217/346 (62%), Gaps = 1/346 (0%) Query: 8 WFWQDRFWLPPNVTWTELED-RDGRVYPHPQDLLAALPLALVLLAMRLAFERFIGLPLSR 66 W W +RFWLP NV+W +LE DG YP + +L+ PLA + +RL FERFI P + Sbjct: 15 WLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFVRLLFERFIAKPCAL 74 Query: 67 WLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDR 126 +G+ D Q +PNA LEK F++ P + +L L+ Q +++ Q WFR RRNQD+ Sbjct: 75 CIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDK 134 Query: 127 PQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLE 186 P KFCE+ WRF FYL F G+ L+ W W CW YP Q L LY +Y++E Sbjct: 135 PPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIME 194 Query: 187 LGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDSSDYLL 246 L FY SL+ D+KRKDF +HH V + L++FSY N++R+G+L++ LHD SD+LL Sbjct: 195 LAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLL 254 Query: 247 EACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFN 306 EA K+ NY +YQ++CD LF+IFS VF TRL ++P IL TT +ES GP+ ++ N Sbjct: 255 EAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLN 314 Query: 307 GLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEE 352 GLL+ LQLLHV WS LI R+ + +G++ KD RSDVE S E+ Sbjct: 315 GLLLTLQLLHVIWSYLIARIALKALIRGKVSKDDRSDVESSSEEED 360 >gi|45007002 longevity assurance homolog 6 [Homo sapiens] Length = 384 Score = 319 bits (818), Expect = 2e-87 Identities = 154/346 (44%), Positives = 218/346 (63%) Query: 8 WFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFIGLPLSRW 67 WFW +RFWLP NVTW +L++ + +P +DL A PLA + +RL FERF+ P + Sbjct: 7 WFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIA 66 Query: 68 LGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRP 127 L ++ + PNA LEK F P E +L L+ Q ++ QRWFR+RRNQ++P Sbjct: 67 LNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKP 126 Query: 128 QLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLEL 187 +FCE+ WRF FYL F G+ L WLW CW YP Q L L+++Y+LEL Sbjct: 127 STLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILEL 186 Query: 188 GFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDSSDYLLE 247 FY SL+ D+KRKDF +HH V++ L+TFSY N+ R+G+LVL LHDS+D LLE Sbjct: 187 SFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLE 246 Query: 248 ACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNG 307 A KM NY ++Q++CD LF++F+ VF TRL +FP +L TT +ES GP+ ++ FN Sbjct: 247 AAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNL 306 Query: 308 LLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEA 353 LL+L+Q L+ FWS LI+++ + +G++ KD RSD+E S E++ Sbjct: 307 LLLLVQGLNCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDEEDS 352 >gi|11641421 LAG1 homolog, ceramide synthase 1 isoform 1 [Homo sapiens] Length = 350 Score = 110 bits (276), Expect = 2e-24 Identities = 92/299 (30%), Positives = 141/299 (47%), Gaps = 22/299 (7%) Query: 84 LEKHFLTEGHRPKEPQLSLLAAQC----GLTLQQTQRWFR--RRRNQDRPQLTKKFCEAS 137 L + L E P+L LLA L T R FR +R +P+ K E++ Sbjct: 44 LARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESA 103 Query: 138 WRFLFYLSSFVGGLSVLYHESWLW---APVMCWDRYPNQTLKPSLYWWYLLELGFY-LSL 193 W+FLFYL S+ +L+ + + P + +D P + + YLL+ FY S+ Sbjct: 104 WKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSI 163 Query: 194 LIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDSSDYLLEACKMVN 253 L D RKD ++HH V +IL+ SY+ +G LVL LHD SD LE K+ Sbjct: 164 YATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNI 223 Query: 254 YMQ---------YQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYF 304 Y + + D L F F +F+ RL FP ++LY T + S+ Y+F Sbjct: 224 YFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFF 283 Query: 305 FNGLLMLLQLLHVFWSCLILRMLYSFMKKGQME--KDIRSDVEESDSSEEAAAAQEPLQ 361 FN LL+LL L++++W I+ + GQ+ KD+R S + + A++PL+ Sbjct: 284 FNALLLLLTLMNLYWFLYIVAFAAKVL-TGQVHELKDLREYDTAEAQSLKPSKAEKPLR 341 >gi|38176296 LAG1 homolog, ceramide synthase 1 isoform 2 [Homo sapiens] Length = 337 Score = 108 bits (271), Expect = 6e-24 Identities = 92/294 (31%), Positives = 139/294 (47%), Gaps = 23/294 (7%) Query: 84 LEKHFLTEGHRPKEPQLSLLAAQC----GLTLQQTQRWFR--RRRNQDRPQLTKKFCEAS 137 L + L E P+L LLA L T R FR +R +P+ K E++ Sbjct: 44 LARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESA 103 Query: 138 WRFLFYLSSFVGGLSVLYHESWLW---APVMCWDRYPNQTLKPSLYWWYLLELGFY-LSL 193 W+FLFYL S+ +L+ + + P + +D P + + YLL+ FY S+ Sbjct: 104 WKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSI 163 Query: 194 LIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDSSDYLLEACKMVN 253 L D RKD ++HH V +IL+ SY+ +G LVL LHD SD LE K+ Sbjct: 164 YATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNI 223 Query: 254 YMQ---------YQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYF 304 Y + + D L F F +F+ RL FP ++LY T + S+ Y+F Sbjct: 224 YFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFF 283 Query: 305 FNGLLMLLQLLHVFWSCLILRMLYSFMKKGQME--KDIRS-DVEESDSSEEAAA 355 FN LL+LL L++++W I+ + GQ+ KD+R D E+ S + + A Sbjct: 284 FNALLLLLTLMNLYWFLYIVAFAAKVL-TGQVHELKDLREYDTAEAQSLKPSKA 336 >gi|6912450 translocation-associated membrane protein 2 [Homo sapiens] Length = 370 Score = 62.0 bits (149), Expect = 9e-10 Identities = 40/155 (25%), Positives = 80/155 (51%), Gaps = 3/155 (1%) Query: 132 KFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYL 191 KF E+ +F+ +S + V+ E +L P W+ YP+ L + ++YL +L ++L Sbjct: 113 KFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWEDYPHVHLPFQVKFFYLCQLAYWL 172 Query: 192 SLLIRLPFD-VKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDSSDYLLEACK 250 L L F V++++ Q+ + + ++ + +Y NL R+G ++LLL S+++L + Sbjct: 173 HALPELYFQKVRKEEIPRQLQYICLYLVHIAGAYLLNLSRLGLILLLLQYSTEFLFHTAR 232 Query: 251 MVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQIL 285 + + + LF ++ VF TRL + +L Sbjct: 233 LFYFADENN--EKLFSAWAAVFGVTRLFILTLAVL 265 >gi|7657655 translocation associated membrane protein 1 [Homo sapiens] Length = 374 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/157 (23%), Positives = 79/157 (50%), Gaps = 7/157 (4%) Query: 132 KFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYL 191 KF E+ FYL + V G +L E+++ P + W YP+ + + ++Y+ +L ++L Sbjct: 118 KFNESGQLSAFYLFACVWGTFILISENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWL 177 Query: 192 SLLIRLPFD-VKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDSSDYLLEACK 250 L F K++D Q+++ + + + +Y NL +G ++L+LH ++L + Sbjct: 178 HAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISR 237 Query: 251 MVNYM--QYQQVCDALFLIFSFVFFYTRLVLFPTQIL 285 + + +YQ+ F +++ +F RL+ +L Sbjct: 238 LFYFSNEKYQKG----FSLWAVLFVLGRLLTLILSVL 270 >gi|145580602 translocation associated membrane protein 1-like 1 [Homo sapiens] Length = 369 Score = 55.5 bits (132), Expect = 8e-08 Identities = 46/181 (25%), Positives = 85/181 (46%), Gaps = 12/181 (6%) Query: 126 RPQLTK----KFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLYW 181 R Q TK KF E+ +FY S + G +L E+ L P + W P+ + + + Sbjct: 108 RMQFTKAKQNKFNESGQFSVFYFFSCIWGTFILISENCLSDPTLIWKARPHSMMTFQMKF 167 Query: 182 WYLLELGFYLSLLIRLPFD-VKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 240 +Y+ +L ++ L F K++D Q+++ + + +T +Y L +G L+L+LH Sbjct: 168 FYISQLAYWFHAFPELYFQKTKKQDIPRQLVYIGLHLFHITGAYLLYLNHLGLLLLVLHY 227 Query: 241 SSDYLLEACKMVNYM--QYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESIS-NRG 297 + L C + + +YQ+ +++ VF RLV +L ++ + S NR Sbjct: 228 FVELLSHMCGLFYFSDEKYQKGIS----LWAIVFILGRLVTLIVSVLTVGFHLAGSQNRN 283 Query: 298 P 298 P Sbjct: 284 P 284 >gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f [Homo sapiens] Length = 1412 Score = 35.4 bits (80), Expect = 0.090 Identities = 24/54 (44%), Positives = 30/54 (55%), Gaps = 3/54 (5%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEPLQLKN-GAAGGPRPAPT--DGPRSRVAG 384 G+ E+D RS EESDS EA AA Q+K G + +PA T GP + AG Sbjct: 392 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 445 Score = 30.0 bits (66), Expect = 3.8 Identities = 14/26 (53%), Positives = 18/26 (69%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEP 359 G+ E+D +S EESDS EEA A +P Sbjct: 327 GKREEDSQSSSEESDSEEEAPAQAKP 352 Score = 28.9 bits (63), Expect = 8.4 Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 9/63 (14%) Query: 332 KKGQMEKDIRSDVEES-DSSEEAAAAQEPLQLKN-------GAAGGP-RPAPTDGPRSRV 382 K G+ E+D S EES DS EE AA+ LQ K GAA P + +P G Sbjct: 254 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 313 Query: 383 AGR 385 G+ Sbjct: 314 PGK 316 >gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e [Homo sapiens] Length = 1451 Score = 35.4 bits (80), Expect = 0.090 Identities = 24/54 (44%), Positives = 30/54 (55%), Gaps = 3/54 (5%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEPLQLKN-GAAGGPRPAPT--DGPRSRVAG 384 G+ E+D RS EESDS EA AA Q+K G + +PA T GP + AG Sbjct: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522 Score = 30.0 bits (66), Expect = 3.8 Identities = 14/26 (53%), Positives = 18/26 (69%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEP 359 G+ E+D +S EESDS EEA A +P Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKP 429 Score = 28.9 bits (63), Expect = 8.4 Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 9/63 (14%) Query: 332 KKGQMEKDIRSDVEES-DSSEEAAAAQEPLQLKN-------GAAGGP-RPAPTDGPRSRV 382 K G+ E+D S EES DS EE AA+ LQ K GAA P + +P G Sbjct: 331 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 390 Query: 383 AGR 385 G+ Sbjct: 391 PGK 393 >gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d [Homo sapiens] Length = 1488 Score = 35.4 bits (80), Expect = 0.090 Identities = 24/54 (44%), Positives = 30/54 (55%), Gaps = 3/54 (5%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEPLQLKN-GAAGGPRPAPT--DGPRSRVAG 384 G+ E+D RS EESDS EA AA Q+K G + +PA T GP + AG Sbjct: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522 Score = 30.0 bits (66), Expect = 3.8 Identities = 14/26 (53%), Positives = 18/26 (69%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEP 359 G+ E+D +S EESDS EEA A +P Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKP 429 Score = 28.9 bits (63), Expect = 8.4 Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 9/63 (14%) Query: 332 KKGQMEKDIRSDVEES-DSSEEAAAAQEPLQLKN-------GAAGGP-RPAPTDGPRSRV 382 K G+ E+D S EES DS EE AA+ LQ K GAA P + +P G Sbjct: 331 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 390 Query: 383 AGR 385 G+ Sbjct: 391 PGK 393 >gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo sapiens] Length = 1411 Score = 35.4 bits (80), Expect = 0.090 Identities = 24/54 (44%), Positives = 30/54 (55%), Gaps = 3/54 (5%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEPLQLKN-GAAGGPRPAPT--DGPRSRVAG 384 G+ E+D RS EESDS EA AA Q+K G + +PA T GP + AG Sbjct: 392 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 445 Score = 30.0 bits (66), Expect = 3.8 Identities = 14/26 (53%), Positives = 18/26 (69%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEP 359 G+ E+D +S EESDS EEA A +P Sbjct: 327 GKREEDSQSSSEESDSEEEAPAQAKP 352 Score = 28.9 bits (63), Expect = 8.4 Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 9/63 (14%) Query: 332 KKGQMEKDIRSDVEES-DSSEEAAAAQEPLQLKN-------GAAGGP-RPAPTDGPRSRV 382 K G+ E+D S EES DS EE AA+ LQ K GAA P + +P G Sbjct: 254 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 313 Query: 383 AGR 385 G+ Sbjct: 314 PGK 316 >gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo sapiens] Length = 1450 Score = 35.4 bits (80), Expect = 0.090 Identities = 24/54 (44%), Positives = 30/54 (55%), Gaps = 3/54 (5%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEPLQLKN-GAAGGPRPAPT--DGPRSRVAG 384 G+ E+D RS EESDS EA AA Q+K G + +PA T GP + AG Sbjct: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522 Score = 30.0 bits (66), Expect = 3.8 Identities = 14/26 (53%), Positives = 18/26 (69%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEP 359 G+ E+D +S EESDS EEA A +P Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKP 429 Score = 28.9 bits (63), Expect = 8.4 Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 9/63 (14%) Query: 332 KKGQMEKDIRSDVEES-DSSEEAAAAQEPLQLKN-------GAAGGP-RPAPTDGPRSRV 382 K G+ E+D S EES DS EE AA+ LQ K GAA P + +P G Sbjct: 331 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 390 Query: 383 AGR 385 G+ Sbjct: 391 PGK 393 >gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo sapiens] Length = 958 Score = 35.4 bits (80), Expect = 0.090 Identities = 24/54 (44%), Positives = 30/54 (55%), Gaps = 3/54 (5%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEPLQLKN-GAAGGPRPAPT--DGPRSRVAG 384 G+ E+D RS EESDS EA AA Q+K G + +PA T GP + AG Sbjct: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522 Score = 30.0 bits (66), Expect = 3.8 Identities = 14/26 (53%), Positives = 18/26 (69%) Query: 334 GQMEKDIRSDVEESDSSEEAAAAQEP 359 G+ E+D +S EESDS EEA A +P Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKP 429 Score = 28.9 bits (63), Expect = 8.4 Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 9/63 (14%) Query: 332 KKGQMEKDIRSDVEES-DSSEEAAAAQEPLQLKN-------GAAGGP-RPAPTDGPRSRV 382 K G+ E+D S EES DS EE AA+ LQ K GAA P + +P G Sbjct: 331 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 390 Query: 383 AGR 385 G+ Sbjct: 391 PGK 393 >gi|224282187 HOP homeobox isoform a [Homo sapiens] Length = 91 Score = 34.7 bits (78), Expect = 0.15 Identities = 15/38 (39%), Positives = 24/38 (63%) Query: 84 LEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRR 121 LE +F P L L+AA+ GL+ ++TQ+WF++R Sbjct: 35 LEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQR 72 >gi|224451023 HOP homeobox isoform b [Homo sapiens] Length = 73 Score = 34.7 bits (78), Expect = 0.15 Identities = 15/38 (39%), Positives = 24/38 (63%) Query: 84 LEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRR 121 LE +F P L L+AA+ GL+ ++TQ+WF++R Sbjct: 17 LEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQR 54 >gi|21264589 HOP homeobox isoform b [Homo sapiens] Length = 73 Score = 34.7 bits (78), Expect = 0.15 Identities = 15/38 (39%), Positives = 24/38 (63%) Query: 84 LEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRR 121 LE +F P L L+AA+ GL+ ++TQ+WF++R Sbjct: 17 LEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQR 54 >gi|21264587 HOP homeobox isoform b [Homo sapiens] Length = 73 Score = 34.7 bits (78), Expect = 0.15 Identities = 15/38 (39%), Positives = 24/38 (63%) Query: 84 LEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRR 121 LE +F P L L+AA+ GL+ ++TQ+WF++R Sbjct: 17 LEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQR 54 >gi|219275578 SIX homeobox 2 [Homo sapiens] Length = 291 Score = 32.3 bits (72), Expect = 0.76 Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 1/71 (1%) Query: 62 LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRR 121 LP S W G + K + L + + + P + LA GLT Q WF+ R Sbjct: 117 LPRSIWDGEETSYCFKEKSRSVLREWYAHNPY-PSPREKRELAEATGLTTTQVSNWFKNR 175 Query: 122 RNQDRPQLTKK 132 R +DR K+ Sbjct: 176 RQRDRAAEAKE 186 >gi|84626580 hypothetical protein LOC80178 [Homo sapiens] Length = 433 Score = 32.3 bits (72), Expect = 0.76 Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 3/67 (4%) Query: 323 ILRMLYSFMKKGQMEKDI---RSDVEESDSSEEAAAAQEPLQLKNGAAGGPRPAPTDGPR 379 +LR+ +F K + S + SDS++ AAA + LQ A+GGP+P + Sbjct: 204 LLRLPAAFRKAASQNSSLWAQLSSTQTSDSTDAAAAKTQFLQNMQTASGGPQPRLSAVEV 263 Query: 380 SRVAGRL 386 AGRL Sbjct: 264 EAEAGRL 270 >gi|4885597 sine oculis homeobox homolog 3 [Homo sapiens] Length = 332 Score = 31.6 bits (70), Expect = 1.3 Identities = 20/70 (28%), Positives = 32/70 (45%), Gaps = 1/70 (1%) Query: 62 LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRR 121 LP + W G + + + + L + +L + + P + LA GLT Q WF+ R Sbjct: 199 LPRTIWDGEQKTHCFKERTRSLLREWYLQDPY-PNPSKKRELAQATGLTPTQVGNWFKNR 257 Query: 122 RNQDRPQLTK 131 R +DR K Sbjct: 258 RQRDRAAAAK 267 >gi|4505623 pre-B-cell leukemia homeobox 1 [Homo sapiens] Length = 430 Score = 31.6 bits (70), Expect = 1.3 Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 5/71 (7%) Query: 65 SRWLGVRDQTRRQVKPNAT--LEKHFLTE--GHRPKEPQLSLLAAQCGLTLQQTQRWFRR 120 SR+L R + RR AT L ++F + P E LA +CG+T+ Q WF Sbjct: 228 SRFLDAR-RKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN 286 Query: 121 RRNQDRPQLTK 131 +R + + + K Sbjct: 287 KRIRYKKNIGK 297 >gi|27436887 pre-B-cell leukemia homeobox 2 [Homo sapiens] Length = 430 Score = 31.6 bits (70), Expect = 1.3 Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 5/71 (7%) Query: 65 SRWLGVRDQTRRQVKPNAT--LEKHFLTE--GHRPKEPQLSLLAAQCGLTLQQTQRWFRR 120 SR+L R + RR AT L ++F + P E LA +CG+T+ Q WF Sbjct: 239 SRFLDAR-RKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN 297 Query: 121 RRNQDRPQLTK 131 +R + + + K Sbjct: 298 KRIRYKKNIGK 308 >gi|157074214 potassium channel, subfamily U, member 1 [Homo sapiens] Length = 1149 Score = 31.6 bits (70), Expect = 1.3 Identities = 57/221 (25%), Positives = 89/221 (40%), Gaps = 26/221 (11%) Query: 122 RNQDRPQLTKKFCEASWRFLFYLSSFV---GGLSVLYHESWLWAPVMCWDRYPNQTLKPS 178 RN+ L K C + F LSSFV GL +L +W V W Q +K + Sbjct: 7 RNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKW-----QIIKGT 61 Query: 179 LYWWYLLELGFYLSLLIR-LPFDVKRKDFKEQVI--HHFVAVILMTFSYSANLLRIGSLV 235 L G +R L F + +D E ++ FV +L+ + +L IGSL+ Sbjct: 62 GIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVF---VLSIGSLI 118 Query: 236 LLLHDSSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISN 295 + +S+D + +C +Y D +F F +F R + +I + SI + Sbjct: 119 IYFINSAD-PVGSCS--SYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVD 175 Query: 296 ----RGPFFGYYFFNGLLML-----LQLLHVFWSCLILRML 327 F YY + L L L+LL + ILR + Sbjct: 176 IFTIPPTFISYYLKSNWLGLRFLRALRLLELPQILQILRAI 216 >gi|5174681 SIX homeobox 1 [Homo sapiens] Length = 284 Score = 30.8 bits (68), Expect = 2.2 Identities = 20/71 (28%), Positives = 29/71 (40%), Gaps = 1/71 (1%) Query: 62 LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRR 121 LP + W G + K L + + + P + LA GLT Q WF+ R Sbjct: 117 LPRTIWDGEETSYCFKEKSRGVLREWYAHNPY-PSPREKRELAEATGLTTTQVSNWFKNR 175 Query: 122 RNQDRPQLTKK 132 R +DR K+ Sbjct: 176 RQRDRAAEAKE 186 >gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens] Length = 739 Score = 30.8 bits (68), Expect = 2.2 Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 3/66 (4%) Query: 62 LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHR-PKEPQLSLLAAQCGLTLQQTQRWFRR 120 LP + W G + + A L+ + G+R P + LA GL+L Q WF+ Sbjct: 194 LPKTIWDGEETVYCFKERSRAALKACY--RGNRYPTPDEKRRLATLTGLSLTQVSNWFKN 251 Query: 121 RRNQDR 126 RR +DR Sbjct: 252 RRQRDR 257 >gi|18860857 menin isoform 1 [Homo sapiens] Length = 615 Score = 30.4 bits (67), Expect = 2.9 Identities = 19/60 (31%), Positives = 29/60 (48%), Gaps = 8/60 (13%) Query: 314 LLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL--QLKNGAAGGPR 371 +LHV W+ +++ L G+ E +R V EAA A+EP + + G GPR Sbjct: 436 VLHVGWATFLVQSL------GRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPR 489 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.327 0.140 0.454 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,436,226 Number of Sequences: 37866 Number of extensions: 681002 Number of successful extensions: 3231 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 42 Number of HSP's successfully gapped in prelim test: 18 Number of HSP's that attempted gapping in prelim test: 3137 Number of HSP's gapped (non-prelim): 93 length of query: 394 length of database: 18,247,518 effective HSP length: 104 effective length of query: 290 effective length of database: 14,309,454 effective search space: 4149741660 effective search space used: 4149741660 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.