Search of human proteins with 194097327

Search of human proteins with 194097327

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
         (474 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...   958   0.0  
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...   763   0.0  
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...   750   0.0  
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso...   745   0.0  
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is...   721   0.0  
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...   368   e-102
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre...   346   2e-95
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...   325   7e-89
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom...   318   7e-87
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec...   317   1e-86
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom...   306   2e-83
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   296   3e-80
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   296   3e-80
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]       291   1e-78
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]         291   1e-78
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]       290   2e-78
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]       289   4e-78
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo...   288   6e-78
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo...   286   3e-77
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso...   283   2e-76
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]       280   2e-75
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...   280   2e-75
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...   280   2e-75
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]       276   3e-74
gi|4504023 glycine receptor, beta [Homo sapiens]                      275   7e-74
gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform...   275   9e-74
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso...   274   1e-73
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr...   273   2e-73
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ...   271   9e-73
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor...   271   1e-72

>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score =  958 bits (2477), Expect = 0.0
 Identities = 474/474 (100%), Positives = 474/474 (100%)

Query: 1   MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP 60
           MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
Sbjct: 1   MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP 60

Query: 61  VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD 120
           VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
Sbjct: 61  VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD 120

Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180
           TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
Sbjct: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180

Query: 181 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240
           SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
Sbjct: 181 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240

Query: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300
           RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
Sbjct: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300

Query: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ 360
           PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ
Sbjct: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ 360

Query: 361 VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR 420
           VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR
Sbjct: 361 VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR 420

Query: 421 HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
           HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
Sbjct: 421 HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score =  763 bits (1969), Expect = 0.0
 Identities = 376/477 (78%), Positives = 421/477 (88%), Gaps = 6/477 (1%)

Query: 1   MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP 60
           MW V+ R   G+ SFP++I  VC A S N+PSNMS VKETVDRLLKGYDIRLRPDFGGPP
Sbjct: 1   MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP 59

Query: 61  VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD 120
           V VGM ID+ASIDMVSEVNMDYTLTMYFQQ+W+DKRLSY+ IPLNLTLDNRVADQLWVPD
Sbjct: 60  VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD 119

Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180
           TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
Sbjct: 120 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 179

Query: 181 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240
           SYGYTTDDIEFYW G + AVTGV KIELPQFSIVDYK+++KKV F+TG+YPRLSLSF+LK
Sbjct: 180 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK 239

Query: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300
           RNIGYFILQTYMPS LITILSWVSFWINYDASAARVALGITTVLTMTTI+THLRETLPKI
Sbjct: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299

Query: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGP--QKKGASKQDQSANEKNKLEMNK 358
           PYVKAID+YLMGCFVFVF+ALLEYA VNYIFFG+GP  QKK A K   + NEK +L++NK
Sbjct: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359

Query: 359 VQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-A 417
             +D H NILLSTLEI+NE + SE +  + DP++TM +YD++SIQYRK    R ++GR A
Sbjct: 360 --MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNA 417

Query: 418 LDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
           L+RH    K R+RRRASQLK+ IPDLTDVN+ID+WSR+FFP+ FS FN+VYWLYYV+
Sbjct: 418 LERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score =  750 bits (1937), Expect = 0.0
 Identities = 376/513 (73%), Positives = 422/513 (82%), Gaps = 40/513 (7%)

Query: 1   MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP 60
           MW V+ R   G+ SFP++I  VC A S N+PSNMS VKETVDRLLKGYDIRLRPDFGGPP
Sbjct: 1   MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP 59

Query: 61  VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD 120
           V VGM ID+ASIDMVSEVNMDYTLTMYFQQ+W+DKRLSY+ IPLNLTLDNRVADQLWVPD
Sbjct: 60  VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD 119

Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180
           TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
Sbjct: 120 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 179

Query: 181 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240
           SYGYTTDDIEFYW G + AVTGV KIELPQFSIVDYK+++KKV F+TG+YPRLSLSF+LK
Sbjct: 180 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK 239

Query: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300
           RNIGYFILQTYMPS LITILSWVSFWINYDASAARVALGITTVLTMTTI+THLRETLPKI
Sbjct: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299

Query: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGP--QKKGASKQDQSANEKNKLEMNK 358
           PYVKAID+YLMGCFVFVF+ALLEYA VNYIFFG+GP  QKK A K   + NEK +L++NK
Sbjct: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359

Query: 359 V------------------------------------QVDAHGNILLSTLEIRNETSGSE 382
           +                                     +D H NILLSTLEI+NE + SE
Sbjct: 360 IFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSE 419

Query: 383 VLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-ALDRHGVPSKGRIRRRASQLKVKIP 441
            +  + DP++TM +YD++SIQYRK    R ++GR AL+RH    K R+RRRASQLK+ IP
Sbjct: 420 AVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIP 479

Query: 442 DLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
           DLTDVN+ID+WSR+FFP+ FS FN+VYWLYYV+
Sbjct: 480 DLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 512


>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 1 precursor [Homo sapiens]
          Length = 473

 Score =  745 bits (1923), Expect = 0.0
 Identities = 367/477 (76%), Positives = 414/477 (86%), Gaps = 7/477 (1%)

Query: 1   MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP 60
           MW +      G+ S PV++ +VCCA S N+P NMS+VKETVD+LLKGYDIRLRPDFGGPP
Sbjct: 1   MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60

Query: 61  VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD 120
           V VGM ID+ASIDMVSEVNMDYTLTMYFQQ W+DKRL+YSGIPLNLTLDNRVADQLWVPD
Sbjct: 61  VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120

Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180
           TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
Sbjct: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180

Query: 181 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240
           SYGYTTDDIEFYW GG+ AVTGV +IELPQFSIV++++VS+ V F TGAYPRLSLSFRLK
Sbjct: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240

Query: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300
           RNIGYFILQTYMPS LITILSWVSFWINYDASAARVALGITTVLTMTTI+THLRETLPKI
Sbjct: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300

Query: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGP--QKKGASKQDQSANEKNKLEMNK 358
           PYVKAID+YLMGCFVFVFLALLEYAFVNYIFFG+GP  QKK A K  ++ N+++K E N+
Sbjct: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360

Query: 359 VQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRAL 418
             VDAHGNILL++LE+ NE   +EV   + D + +  S+D++ IQYRK    RE +GR L
Sbjct: 361 --VDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFL 416

Query: 419 DRHGVP-SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
               +P  K  +RRR+SQLK+KIPDLTDVN+ID+WSR+ FP TFSLFN+VYWLYYV+
Sbjct: 417 GDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473


>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 2 precursor [Homo sapiens]
          Length = 473

 Score =  721 bits (1860), Expect = 0.0
 Identities = 357/451 (79%), Positives = 399/451 (88%), Gaps = 7/451 (1%)

Query: 27  STNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTM 86
           S N+P NMS+VKETVD+LLKGYDIRLRPDFGGPPV VGM ID+ASIDMVSEVNMDYTLTM
Sbjct: 27  SVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTM 86

Query: 87  YFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPD 146
           YFQQ W+DKRL+YSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPD
Sbjct: 87  YFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPD 146

Query: 147 GTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKI 206
           GTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW GG+ AVTGV +I
Sbjct: 147 GTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERI 206

Query: 207 ELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFW 266
           ELPQFSIV++++VS+ V F TGAYPRLSLSFRLKRNIGYFILQTYMPS LITILSWVSFW
Sbjct: 207 ELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFW 266

Query: 267 INYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAF 326
           INYDASAARVALGITTVLTMTTI+THLRETLPKIPYVKAID+YLMGCFVFVFLALLEYAF
Sbjct: 267 INYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAF 326

Query: 327 VNYIFFGKGP--QKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVL 384
           VNYIFFG+GP  QKK A K  ++ N+++K E N+  VDAHGNILL++LE+ NE   +EV 
Sbjct: 327 VNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR--VDAHGNILLTSLEVHNEM--NEVS 382

Query: 385 TSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVP-SKGRIRRRASQLKVKIPDL 443
             + D + +  S+D++ IQYRK    RE +GR L    +P  K  +RRR+SQLK+KIPDL
Sbjct: 383 GGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDL 442

Query: 444 TDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
           TDVN+ID+WSR+ FP TFSLFN+VYWLYYV+
Sbjct: 443 TDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score =  368 bits (944), Expect = e-102
 Identities = 165/323 (51%), Positives = 241/323 (74%), Gaps = 4/323 (1%)

Query: 17  VMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVS 76
           V++ +  C +  NE    + V++ +DR+L  YD+RLRP+FGG PV V + I V SI+ +S
Sbjct: 43  VVLNLFNCKNCANE----AVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQIS 98

Query: 77  EVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTV 136
           E+NMDYT+TM+F Q+WKD RL+Y    LNLTLD R+ ++LWVPD YFLN K +FVH VTV
Sbjct: 99  EMNMDYTITMFFHQTWKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTV 158

Query: 137 KNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGG 196
           +NR+ +LHPDGTV YG+R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI  +W+  
Sbjct: 159 ENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDN 218

Query: 197 EGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTL 256
             A+    ++ +PQF+ +   + SK+V F TG+Y RL L F+++R +  +++Q Y P+ L
Sbjct: 219 GNAIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVL 278

Query: 257 ITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVF 316
            TI SW+SFW+NYD+SAARV +G+T++L +TTI +HLR+ LP I  +KAIDIY++ C  F
Sbjct: 279 TTITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFF 338

Query: 317 VFLALLEYAFVNYIFFGKGPQKK 339
           VFL+LLEY ++NY+F+ +GP+++
Sbjct: 339 VFLSLLEYVYINYLFYSRGPRRQ 361



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 16/29 (55%), Positives = 23/29 (79%)

Query: 446 VNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
           V  +DKWSR  FP+ F LFN+VYW+Y+++
Sbjct: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632


>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
           precursor [Homo sapiens]
          Length = 452

 Score =  346 bits (888), Expect = 2e-95
 Identities = 182/436 (41%), Positives = 270/436 (61%), Gaps = 33/436 (7%)

Query: 41  VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
           +D L+ GY    RP  GGPPV+V + ++VASID +SE NM+YT+T++  QSW+D RLSY+
Sbjct: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                L LD+R  D+LW+PDT+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T A
Sbjct: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163

Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVS 220
           C MDL +YP+DEQ C L++ESYGY+++DI +YW+  +  + G++K++L QF+I  Y+  +
Sbjct: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223

Query: 221 KKVEF-TTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALG 279
           + + F + G +PRLSL F L+RN G +I+Q+YMPS L+  +SWVSFWI+  A  ARV+LG
Sbjct: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283

Query: 280 ITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKK 339
           ITTVLTMTT+    R +LP+   +KA+D+Y   C+VFVF AL+EYAF ++    +  QK 
Sbjct: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQK- 342

Query: 340 GASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSD---PKATMYS 396
                      K K+   + ++D    I+L +L     T   E+  S      P   M S
Sbjct: 343 ----------AKVKVSRPRAEMDVRNAIVLFSLSAAGVT--QELAISRRQRRVPGNLMGS 390

Query: 397 YDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMF 456
           Y S  ++  +  + +E   R+        +G IR R   +        D ++ID ++R  
Sbjct: 391 YRSVGVETGE--TKKEGAARS------GGQGGIRARLRPI--------DADTIDIYARAV 434

Query: 457 FPITFSLFNVVYWLYY 472
           FP  F+  NV+YW  Y
Sbjct: 435 FPAAFAAVNVIYWAAY 450


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score =  325 bits (832), Expect = 7e-89
 Identities = 179/436 (41%), Positives = 259/436 (59%), Gaps = 41/436 (9%)

Query: 42  DRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSG 101
           + L  GY+  LRP+FGG PV + + +D+ASI  +SE NMDYT T+Y +Q W D+RL + G
Sbjct: 42  ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101

Query: 102 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 161
              + TLD R+ + LWVPDTY +  KKSF+H VTV NR+IRL  +GTVLY LRITTT AC
Sbjct: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160

Query: 162 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSK 221
            MDL +YP+D Q C L++ES+GY  +D+EF W  G  +V G+  + L Q++I  Y  +  
Sbjct: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220

Query: 222 KVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGIT 281
           + +  TG Y RL L F L+RN+ YFIL+TY+PST + +LSWVSFWI+ D+  AR  +G+T
Sbjct: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280

Query: 282 TVLTMTTISTHLRETLPKIP-YVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKG 340
           TVL+MTT+    R +LP    ++KAID+YL  CF FVF ALLEYA  +Y           
Sbjct: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY----------- 329

Query: 341 ASKQDQSANEKNKL-EMNKVQVDAHGNILLSTLEIRNETSGSEVLT-SVSDPKATMYSYD 398
           +S Q  +A ++    E+ +V +    N  +S+ + +   +  E+ + +V     TM + D
Sbjct: 330 SSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSD 389

Query: 399 SASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFP 458
                +      RE  GR +D   + +                     +++D +S++ FP
Sbjct: 390 KFKFVF------REKMGRIVDYFTIQNP--------------------SNVDHYSKLLFP 423

Query: 459 ITFSLFNVVYWLYYVH 474
           + F L NV YW YY++
Sbjct: 424 LIFMLANVFYWAYYMY 439


>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
           sapiens]
          Length = 479

 Score =  318 bits (815), Expect = 7e-87
 Identities = 175/431 (40%), Positives = 252/431 (58%), Gaps = 48/431 (11%)

Query: 48  YDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSY-SGIPLNL 106
           +D  +RP FGGP + VG+ + V S+D +SEV+MD+T+T+Y +  WKD+RLS+ S   L++
Sbjct: 84  HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143

Query: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166
           T D R+  ++WVPD +F++ K+SF+H  T  N M+R+ PDG VLY LR+T TA C MD  
Sbjct: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203

Query: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFT 226
           R+PLD Q C+LEIESY YT DD+  YW  G  ++    +I L QF I ++   +K   ++
Sbjct: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263

Query: 227 -TGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLT 285
            TG Y RL ++F L+R+I +F+LQTY P+TL+ +LSWVSFWI+  A  ARV LGITTVLT
Sbjct: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323

Query: 286 MTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQD 345
           M+TI T +  ++P++ Y+KA+DIYL   FVFVFL++LEYA VNY                
Sbjct: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNY---------------- 367

Query: 346 QSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVS---DPKATM----YSYD 398
                                  L+T++ R E    E L   S    P+  M    YS  
Sbjct: 368 -----------------------LTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDG 404

Query: 399 SASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFP 458
             +        + E   R + +  + S+    +R SQ    +    D ++IDK+SR+ FP
Sbjct: 405 EVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFP 464

Query: 459 ITFSLFNVVYW 469
             + LFN++YW
Sbjct: 465 AAYILFNLIYW 475


>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
           precursor [Homo sapiens]
          Length = 490

 Score =  317 bits (813), Expect = 1e-86
 Identities = 167/426 (39%), Positives = 254/426 (59%), Gaps = 32/426 (7%)

Query: 48  YDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIP-LNL 106
           +D  +RP FGGP + VG+ + V S+D +SEV+MD+T+T+Y +  WKD+RL++S     ++
Sbjct: 89  HDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSM 148

Query: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166
           T D R+  ++WVPD +F++ K+SF H  T  N M+R+ PDG VLY +RIT TA C MD  
Sbjct: 149 TFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFS 208

Query: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFT 226
            +PLD Q C+LE+ESY YT +D+  YW  G+ ++    KI L QF I  +   S+   ++
Sbjct: 209 HFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYS 268

Query: 227 -TGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLT 285
            TG Y RL ++F L+R+I +F+LQTY P+TL+ +LSWVSFWI+  A  ARV+LGITTVLT
Sbjct: 269 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLT 328

Query: 286 MTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQD 345
           MTTI T +  ++P++ YVKA+DIYL   FVFVFL++LEYA VNY+               
Sbjct: 329 MTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYL--------------- 373

Query: 346 QSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYR 405
            +  E+ + ++ +      G +   T+ +    S SE  +    P++ +           
Sbjct: 374 TTVQERKERKLREKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHI----------- 422

Query: 406 KPLSSREAYGRALDRHGVPSKGRIRRRASQLK--VKIPDLTDVNSIDKWSRMFFPITFSL 463
             L+  E   + +   G+  +    R+   LK         + ++IDK+SR+ FP ++  
Sbjct: 423 --LTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIF 480

Query: 464 FNVVYW 469
           FN++YW
Sbjct: 481 FNLIYW 486


>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
           sapiens]
          Length = 467

 Score =  306 bits (785), Expect = 2e-83
 Identities = 172/428 (40%), Positives = 251/428 (58%), Gaps = 34/428 (7%)

Query: 49  DIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSY-SGIPLNLT 107
           D  +RP FGG PV VG+ + V SID +SE NMD+T+T Y +  WKD+RLS+ S    ++T
Sbjct: 71  DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130

Query: 108 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 167
            D+R+  ++WVPD +F++ K+SF+H  T++N M+R+HPDG VL  LRIT +A C MD  R
Sbjct: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190

Query: 168 YPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEF-T 226
           +PLD QNC+LE+ESY Y  DD+  YW  G  ++     + L QF I D+   S    + +
Sbjct: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250

Query: 227 TGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTM 286
           TG Y RL ++F L+R++ +F+LQTY P+ L+ +LSWVSFWI+  A  ARV+LGITTVLTM
Sbjct: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310

Query: 287 TTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQ 346
           +TI T +  ++P++ Y+KA+D+YL    +FVFL+++EYA VNY+           + +++
Sbjct: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL----------TTVEER 360

Query: 347 SANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRK 406
              +K         +DA     +  +        SE+     D   T  S +S     RK
Sbjct: 361 KQFKKTGKISRMYNIDA-----VQAMAFDGCYHDSEI-----DMDQTSLSLNSEDFMRRK 410

Query: 407 PLSSREAYGRALDRHGVPSKGRIRRRAS-QLKVKIPDLTDVNSIDKWSRMFFPITFSLFN 465
            + S                 RI+RR S    V    L + + ID +SR+ FPI + LFN
Sbjct: 411 SICSPST-----------DSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFN 459

Query: 466 VVYWLYYV 473
           + YW  YV
Sbjct: 460 LFYWGVYV 467


>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
           precursor [Homo sapiens]
          Length = 467

 Score =  296 bits (758), Expect = 3e-80
 Identities = 163/434 (37%), Positives = 243/434 (55%), Gaps = 37/434 (8%)

Query: 41  VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
           ++ LL+GYD +LRPD G  P  +   + V SI  V+ +NM+YT+ ++F Q+W D+RL ++
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                L L++ +  ++W+PDT+F N KK+  H +T  NRM+R+  DG VLY LR+T  A 
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVS 220
           C + L  +P+DE +C LE  SYGY  ++I + W      V       L QFS V  +  +
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249

Query: 221 KKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGI 280
           + V+ T+G Y  +S+ F L R +GYF +QTY+P TLI +LSWVSFWIN DA  AR +LGI
Sbjct: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309

Query: 281 TTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKG 340
           TTVLTMTT+ST  R++LPK+ YV A+D+++  CF+FVF AL+EY  ++Y    + P K  
Sbjct: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSK-- 367

Query: 341 ASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSA 400
             K  +  N    +++         N   + L+ R+E  G E L    D  +    ++  
Sbjct: 368 -DKDKKKKNPAPTIDIRPRSATIQMN-NATHLQERDEEYGYECLDG-KDCASFFCCFEDC 424

Query: 401 SIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPIT 460
                              R G    GRI  R +++             D ++R+FFP  
Sbjct: 425 -------------------RTGAWRHGRIHIRIAKM-------------DSYARIFFPTA 452

Query: 461 FSLFNVVYWLYYVH 474
           F LFN+VYW+ Y++
Sbjct: 453 FCLFNLVYWVSYLY 466


>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
           precursor [Homo sapiens]
          Length = 475

 Score =  296 bits (758), Expect = 3e-80
 Identities = 170/449 (37%), Positives = 250/449 (55%), Gaps = 59/449 (13%)

Query: 41  VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
           ++ LL+GYD +LRPD G  P  +   + V SI  V+ +NM+YT+ ++F Q+W D+RL ++
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                L L++ +  ++W+PDT+F N KK+  H +T  NRM+R+  DG VLY LR+T  A 
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVS 220
           C + L  +P+DE +C LE  SYGY  ++I + W      V       L QFS V  +  +
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249

Query: 221 KKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGI 280
           + V+ T+G Y  +S+ F L R +GYF +QTY+P TLI +LSWVSFWIN DA  AR +LGI
Sbjct: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309

Query: 281 TTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKG 340
           TTVLTMTT+ST  R++LPK+ YV A+D+++  CF+FVF AL+EY  ++Y    + P K  
Sbjct: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSK-- 367

Query: 341 ASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSA 400
               D+   +KN L +      A       T++IR  +             AT+   ++ 
Sbjct: 368 ----DKDKKKKNPL-LRMFSFKA------PTIDIRPRS-------------ATIQMNNAT 403

Query: 401 SIQYRKPLSSREAYG-RALD--------------RHGVPSKGRIRRRASQLKVKIPDLTD 445
            +Q R      E YG   LD              R G    GRI  R +++         
Sbjct: 404 HLQERD-----EEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKM--------- 449

Query: 446 VNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
               D ++R+FFP  F LFN+VYW+ Y++
Sbjct: 450 ----DSYARIFFPTAFCLFNLVYWVSYLY 474


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  291 bits (744), Expect = 1e-78
 Identities = 168/453 (37%), Positives = 252/453 (55%), Gaps = 48/453 (10%)

Query: 25  AHSTNEPSNMSYVKETVDRLL---KGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMD 81
           + S  +PS      + +D+L+    GYD R+RP+F GPPV+V   I + S   V+E  MD
Sbjct: 32  SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMD 91

Query: 82  YTLTMYFQQSWKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 140
           Y + ++ +Q W D RL+YS  P + L LD  + D +W PD +F N+K +  H VT  N++
Sbjct: 92  YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151

Query: 141 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAV 200
           +R+  +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W   +G V
Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGPV 210

Query: 201 TGVNKIELPQFSIVDYKMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITI 259
                + LPQF + + K +    + + TG +  + + F L+R +GY+++Q Y+PS LI I
Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVI 270

Query: 260 LSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFL 319
           LSWVSFWIN DA+ ARVALGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF 
Sbjct: 271 LSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFA 330

Query: 320 ALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETS 379
           ALLEYA VN++        +   +Q +   E++    ++     +G  +   L++++ T+
Sbjct: 331 ALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYG--MGHCLQVKDGTA 388

Query: 380 GSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVK 439
                      KAT             PL      G A+ +  V    R           
Sbjct: 389 ----------VKATP----------ANPLPQPPKDGDAIKKKFVDRAKR----------- 417

Query: 440 IPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYY 472
                    ID  SR  FP+ F +FN+ YW+ Y
Sbjct: 418 ---------IDTISRAAFPLAFLIFNIFYWITY 441


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  291 bits (744), Expect = 1e-78
 Identities = 168/453 (37%), Positives = 252/453 (55%), Gaps = 48/453 (10%)

Query: 25  AHSTNEPSNMSYVKETVDRLL---KGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMD 81
           + S  +PS      + +D+L+    GYD R+RP+F GPPV+V   I + S   V+E  MD
Sbjct: 32  SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMD 91

Query: 82  YTLTMYFQQSWKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 140
           Y + ++ +Q W D RL+YS  P + L LD  + D +W PD +F N+K +  H VT  N++
Sbjct: 92  YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151

Query: 141 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAV 200
           +R+  +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W   +G V
Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGPV 210

Query: 201 TGVNKIELPQFSIVDYKMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITI 259
                + LPQF + + K +    + + TG +  + + F L+R +GY+++Q Y+PS LI I
Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVI 270

Query: 260 LSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFL 319
           LSWVSFWIN DA+ ARVALGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF 
Sbjct: 271 LSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFA 330

Query: 320 ALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETS 379
           ALLEYA VN++        +   +Q +   E++    ++     +G  +   L++++ T+
Sbjct: 331 ALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYG--MGHCLQVKDGTA 388

Query: 380 GSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVK 439
                      KAT             PL      G A+ +  V    R           
Sbjct: 389 ----------VKATP----------ANPLPQPPKDGDAIKKKFVDRAKR----------- 417

Query: 440 IPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYY 472
                    ID  SR  FP+ F +FN+ YW+ Y
Sbjct: 418 ---------IDTISRAAFPLAFLIFNIFYWITY 441


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score =  290 bits (743), Expect = 2e-78
 Identities = 167/453 (36%), Positives = 252/453 (55%), Gaps = 48/453 (10%)

Query: 25  AHSTNEPSNMSYVKETVDRLL---KGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMD 81
           + S  +PS      + +D+L+    GYD R+RP+F GPPV+V   I + S   ++E  MD
Sbjct: 32  SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMD 91

Query: 82  YTLTMYFQQSWKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 140
           Y + ++ +Q W D RL+YS  P + L LD  + D +W PD +F N+K +  H VT  N++
Sbjct: 92  YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151

Query: 141 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAV 200
           +R+  +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W   +G V
Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGPV 210

Query: 201 TGVNKIELPQFSIVDYKMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITI 259
                + LPQF + + K +    + + TG +  + + F L+R +GY+++Q Y+PS LI I
Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVI 270

Query: 260 LSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFL 319
           LSWVSFWIN DA+ ARVALGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF 
Sbjct: 271 LSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFA 330

Query: 320 ALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETS 379
           ALLEYA VN++        +   +Q +   E++    ++     +G  +   L++++ T+
Sbjct: 331 ALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYG--MGHCLQVKDGTA 388

Query: 380 GSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVK 439
                      KAT             PL      G A+ +  V    R           
Sbjct: 389 ----------VKATP----------ANPLPQPPKDGDAIKKKFVDRAKR----------- 417

Query: 440 IPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYY 472
                    ID  SR  FP+ F +FN+ YW+ Y
Sbjct: 418 ---------IDTISRAAFPLAFLIFNIFYWITY 441


>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
          Length = 464

 Score =  289 bits (739), Expect = 4e-78
 Identities = 171/459 (37%), Positives = 248/459 (54%), Gaps = 52/459 (11%)

Query: 25  AHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTL 84
           A S + P + S   + +     GYD R+RP+F GPPV+V   I + S   ++E  MDY +
Sbjct: 34  ARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRV 93

Query: 85  TMYFQQSWKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRL 143
            ++ +Q W D RL+YS  P + L LD  + D +W PD +F N+K +  H VT  N+++R+
Sbjct: 94  NIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRI 153

Query: 144 HPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGV 203
             +G VLY +R+T T +C MDL+ +P+D Q C +++ES+GYT +D+ F W   E  V   
Sbjct: 154 FKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQD-EAPVQVA 212

Query: 204 NKIELPQFSIVDYKMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSW 262
             + LPQF + + K +    + + TG +  + + F L+R +GY+++Q Y+PS LI ILSW
Sbjct: 213 EGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSW 272

Query: 263 VSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALL 322
           VSFWIN DA+ ARVALGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF ALL
Sbjct: 273 VSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALL 332

Query: 323 EYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSE 382
           EYA VN++           S+Q +      +   NK +  A        LE         
Sbjct: 333 EYAAVNFV-----------SRQHKELLRFRRKRKNKTEAFA--------LE--------- 364

Query: 383 VLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRA---LDRHGVPSKGRIRRRASQLKVK 439
                       Y +     + R+   S  AYG       + G+  KG       Q+  K
Sbjct: 365 ----------KFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKG--PNHPVQVMPK 412

Query: 440 IPD------LTDVNSIDKWSRMFFPITFSLFNVVYWLYY 472
            PD      +     ID  SR  FP+ F +FN+ YW+ Y
Sbjct: 413 SPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 451


>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 457

 Score =  288 bits (738), Expect = 6e-78
 Identities = 169/451 (37%), Positives = 250/451 (55%), Gaps = 36/451 (7%)

Query: 25  AHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTL 84
           A S  +P + S   + +     GYD R+RP+F GPPV+V   I + S   ++E  MDY +
Sbjct: 29  ARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRV 88

Query: 85  TMYFQQSWKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRL 143
            ++ +Q W D RL+Y+  P + L LD  + D +W PD +F N+K +  H +T  N+++R+
Sbjct: 89  NIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRI 148

Query: 144 HPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGV 203
             +G VLY +RIT T AC MDL+ +P+D Q C +++ES+GYT +D+ F W   +GAV   
Sbjct: 149 SRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVA 207

Query: 204 NKIELPQFSIVDYKMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSW 262
           + + LPQF + + K +    + + TG +  +   F L+R +GY+++Q Y+PS LI ILSW
Sbjct: 208 DGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSW 267

Query: 263 VSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALL 322
           +SFWIN DA+ ARV LGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF ALL
Sbjct: 268 ISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALL 327

Query: 323 EYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSE 382
           EYA VN++      Q K   +  +         +N  Q D  G       E R   S   
Sbjct: 328 EYAAVNFV----SRQHKELLRFRRKRRHHKSPMLNLFQEDEAG-------EGRFNFSA-- 374

Query: 383 VLTSVSDPKATMYSYDSASIQYRKPLSSREA-YGRALDRHGVPSKGRIRRRASQLKVKIP 441
                       Y    A +Q +  +S + A      +    PSK       S  +++  
Sbjct: 375 ------------YGMGPACLQAKDGISVKGANNSNTTNPPPAPSK-------SPEEMRKL 415

Query: 442 DLTDVNSIDKWSRMFFPITFSLFNVVYWLYY 472
            +     IDK SR+ FP+ F +FN+ YW+ Y
Sbjct: 416 FIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 446


>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 449

 Score =  286 bits (732), Expect = 3e-77
 Identities = 164/451 (36%), Positives = 247/451 (54%), Gaps = 44/451 (9%)

Query: 25  AHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTL 84
           A S  +P + S   + +     GYD R+RP+F GPPV+V   I + S   ++E  MDY +
Sbjct: 29  ARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRV 88

Query: 85  TMYFQQSWKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRL 143
            ++ +Q W D RL+Y+  P + L LD  + D +W PD +F N+K +  H +T  N+++R+
Sbjct: 89  NIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRI 148

Query: 144 HPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGV 203
             +G VLY +RIT T AC MDL+ +P+D Q C +++ES+GYT +D+ F W   +GAV   
Sbjct: 149 SRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVA 207

Query: 204 NKIELPQFSIVDYKMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSW 262
           + + LPQF + + K +    + + TG +  +   F L+R +GY+++Q Y+PS LI ILSW
Sbjct: 208 DGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSW 267

Query: 263 VSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALL 322
           +SFWIN DA+ ARV LGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF ALL
Sbjct: 268 ISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALL 327

Query: 323 EYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSE 382
           EYA VN++          + +  +    + K   +K      G    S            
Sbjct: 328 EYAAVNFV----------SRQHKELLRFRRKRRHHKEDEAGEGRFNFSA----------- 366

Query: 383 VLTSVSDPKATMYSYDSASIQYRKPLSSREA-YGRALDRHGVPSKGRIRRRASQLKVKIP 441
                       Y    A +Q +  +S + A      +    PSK       S  +++  
Sbjct: 367 ------------YGMGPACLQAKDGISVKGANNSNTTNPPPAPSK-------SPEEMRKL 407

Query: 442 DLTDVNSIDKWSRMFFPITFSLFNVVYWLYY 472
            +     IDK SR+ FP+ F +FN+ YW+ Y
Sbjct: 408 FIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 438


>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
           [Homo sapiens]
          Length = 465

 Score =  283 bits (724), Expect = 2e-76
 Identities = 158/438 (36%), Positives = 237/438 (54%), Gaps = 37/438 (8%)

Query: 37  VKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKR 96
           + + ++ LL+GYD +LRPD G  P  +   + V SI  V  +NM+YT+ + F Q+W D R
Sbjct: 64  ITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSR 123

Query: 97  LSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156
           L ++     L L++ +  ++W+PDT+F N +KS  H +T  NR++R+  DG VLY LR+T
Sbjct: 124 LKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLT 183

Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDY 216
             A C + L  +P+DE +C LE  SYGY  ++IE+ W      V       L QF+ V  
Sbjct: 184 INAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGL 243

Query: 217 KMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARV 276
           +  ++     +G Y  +++ F L R +GYF +QTY+P  L  +LSWVSFWIN DA  AR 
Sbjct: 244 RNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPART 303

Query: 277 ALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGP 336
           +LGITTVLTMTT+ST  R++LPK+ YV A+D+++  CF+FVF AL+EY  ++Y  F    
Sbjct: 304 SLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHY--FTSNQ 361

Query: 337 QKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYS 396
           + K A+K  +    KNK  M          I ++ + +  E           D  +    
Sbjct: 362 KGKTATKDRKL---KNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCC 418

Query: 397 YDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMF 456
           ++                     R G   +GRI  R             +  ID +SR+F
Sbjct: 419 FEDC-------------------RTGSWREGRIHIR-------------IAKIDSYSRIF 446

Query: 457 FPITFSLFNVVYWLYYVH 474
           FP  F+LFN+VYW+ Y++
Sbjct: 447 FPTAFALFNLVYWVGYLY 464


>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
          Length = 449

 Score =  280 bits (717), Expect = 2e-75
 Identities = 162/450 (36%), Positives = 249/450 (55%), Gaps = 49/450 (10%)

Query: 25  AHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTL 84
           A S + P + S   + +     GYD R+RP+F GPPV+V   I + S   ++E  MDY +
Sbjct: 34  ARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRV 93

Query: 85  TMYFQQSWKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRL 143
            ++ +Q W D RL+YS  P + L LD  + D +W PD +F N+K +  H VT  N+++R+
Sbjct: 94  NIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRI 153

Query: 144 HPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGV 203
             +G VLY +R+T T +C MDL+ +P+D Q C +++ES+GYT +D+ F W   E  V   
Sbjct: 154 FKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQD-EAPVQVA 212

Query: 204 NKIELPQFSIVDYKMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSW 262
             + LPQF + + K +    + + TG +  + + F L+R +GY+++Q Y+PS LI ILSW
Sbjct: 213 EGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSW 272

Query: 263 VSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALL 322
           VSFWIN DA+ ARVALGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF ALL
Sbjct: 273 VSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALL 332

Query: 323 EYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSE 382
           EYA VN++       K+    + +  N+ +++  ++    A+G  +   L+ ++  +   
Sbjct: 333 EYAAVNFV---SRQHKELLRFRRKRKNKDDEVRESRFSFTAYG--MGPCLQAKDGMT--- 384

Query: 383 VLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPD 442
                  PK   +      +  + P   R+ +   +DR                      
Sbjct: 385 -------PKGPNH---PVQVMPKSPDEMRKVF---IDR---------------------- 409

Query: 443 LTDVNSIDKWSRMFFPITFSLFNVVYWLYY 472
                 ID  SR  FP+ F +FN+ YW+ Y
Sbjct: 410 ---AKKIDTISRACFPLAFLIFNIFYWVIY 436


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score =  280 bits (716), Expect = 2e-75
 Identities = 153/446 (34%), Positives = 240/446 (53%), Gaps = 43/446 (9%)

Query: 32  SNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQS 91
           +N++     +DRLL GYD RLRP  G    +V   I V S   VS+ +M+YT+ ++F+Q 
Sbjct: 37  NNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQK 96

Query: 92  WKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVL 150
           WKD+RL + G P+N L L+N +A ++W PDT+F N KKS  H +T+ N+++R+  DGT+L
Sbjct: 97  WKDERLKFKG-PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLL 155

Query: 151 YGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW--NGGEGAVTGVNKIEL 208
           Y +R+T  A C M L  +P+D  +C L+  SY YTT ++ + W  N  +      +   L
Sbjct: 156 YTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRL 215

Query: 209 PQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWIN 268
            Q+ ++   +  + ++ +TG Y  ++  F LKR IGYF++QTY+P  +  ILS VSFW+N
Sbjct: 216 NQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN 275

Query: 269 YDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVN 328
            ++  AR   G+TTVLTMTT+S   R +LPK+ Y  A+D ++  C+ FVF AL+E+A VN
Sbjct: 276 RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN 335

Query: 329 YIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVS 388
           Y        K+G +   +S     K E   V +  +    ++        S   VL+++S
Sbjct: 336 YF------TKRGWAWDGKSVVNDKKKEKASVMIQ-NNAYAVAVANYAPNLSKDPVLSTIS 388

Query: 389 DPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNS 448
               T    +       KP  +++ +                               V+ 
Sbjct: 389 KSATTP---EPNKKPENKPAEAKKTF-----------------------------NSVSK 416

Query: 449 IDKWSRMFFPITFSLFNVVYWLYYVH 474
           ID+ SR+ FP+ F  FN+VYW  Y++
Sbjct: 417 IDRMSRIVFPVLFGTFNLVYWATYLN 442


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score =  280 bits (716), Expect = 2e-75
 Identities = 153/446 (34%), Positives = 240/446 (53%), Gaps = 43/446 (9%)

Query: 32  SNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQS 91
           +N++     +DRLL GYD RLRP  G    +V   I V S   VS+ +M+YT+ ++F+Q 
Sbjct: 37  NNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQK 96

Query: 92  WKDKRLSYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVL 150
           WKD+RL + G P+N L L+N +A ++W PDT+F N KKS  H +T+ N+++R+  DGT+L
Sbjct: 97  WKDERLKFKG-PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLL 155

Query: 151 YGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW--NGGEGAVTGVNKIEL 208
           Y +R+T  A C M L  +P+D  +C L+  SY YTT ++ + W  N  +      +   L
Sbjct: 156 YTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRL 215

Query: 209 PQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWIN 268
            Q+ ++   +  + ++ +TG Y  ++  F LKR IGYF++QTY+P  +  ILS VSFW+N
Sbjct: 216 NQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN 275

Query: 269 YDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVN 328
            ++  AR   G+TTVLTMTT+S   R +LPK+ Y  A+D ++  C+ FVF AL+E+A VN
Sbjct: 276 RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN 335

Query: 329 YIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVS 388
           Y        K+G +   +S     K E   V +  +    ++        S   VL+++S
Sbjct: 336 YF------TKRGWAWDGKSVVNDKKKEKASVMIQ-NNAYAVAVANYAPNLSKDPVLSTIS 388

Query: 389 DPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNS 448
               T    +       KP  +++ +                               V+ 
Sbjct: 389 KSATTP---EPNKKPENKPAEAKKTF-----------------------------NSVSK 416

Query: 449 IDKWSRMFFPITFSLFNVVYWLYYVH 474
           ID+ SR+ FP+ F  FN+VYW  Y++
Sbjct: 417 IDRMSRIVFPVLFGTFNLVYWATYLN 442


>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
          Length = 417

 Score =  276 bits (706), Expect = 3e-74
 Identities = 135/295 (45%), Positives = 196/295 (66%), Gaps = 5/295 (1%)

Query: 41  VDRLL---KGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRL 97
           +D+L+    GYD R+RP+F GPPV+V   I + S   +++  MDY + ++ +Q W D RL
Sbjct: 48  LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRL 107

Query: 98  SYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156
           SY   P + L LD  + D +W PD +F N+K +  H VT  N+++R+  +G VLY +R+T
Sbjct: 108 SYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 167

Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDY 216
              +C+MDL+ +P+D Q CT+++ES+GYT  D+ F W     AV     + LPQF + D 
Sbjct: 168 LILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDE 227

Query: 217 KMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAAR 275
           K +    + + TG +  + + F L+R +GY+++Q Y+PS LI ILSWVSFWIN DA+ AR
Sbjct: 228 KDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 287

Query: 276 VALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYI 330
           V LGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF ALLEYA +N++
Sbjct: 288 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFV 342


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score =  275 bits (703), Expect = 7e-74
 Identities = 162/448 (36%), Positives = 253/448 (56%), Gaps = 25/448 (5%)

Query: 41  VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
           ++RLL  YD R+RP+F G PVDV + I + S   + E  MDY + ++ +Q W D RL   
Sbjct: 60  LNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLK-- 117

Query: 101 GIPLN------LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLR 154
            +P +      LT+D  +   LW PD +F N+K +  H VT +N ++ +  DG VL  +R
Sbjct: 118 -LPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMR 176

Query: 155 ITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSI- 213
           ++ T +C +DL  +P+D Q C +++ES+GYTTDD+ F W  G+     + KI LPQF I 
Sbjct: 177 LSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQ--LEKIALPQFDIK 234

Query: 214 ---VDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYD 270
              ++Y   +K  +  TG Y  + + F L+R +G++++  Y P+ LI +LSW+SFWIN D
Sbjct: 235 KEDIEYGNCTKYYK-GTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPD 293

Query: 271 ASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYI 330
           ASAARV LGI +VL++ +  T L   LPK+ YVKA+D++L+ C +F F +L+EYA V  +
Sbjct: 294 ASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVM 353

Query: 331 FFGKGPQKKGASK----QDQSANEKNKLEMNKVQVDAHGN-ILLSTLEIRNETSGSEVLT 385
                P++  A K    + + A+ K      K  V+  G  + +STL++  ET   +V T
Sbjct: 354 L--NNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQV-GETRCKKVCT 410

Query: 386 SVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTD 445
           S SD ++  +S    S+     LS+ + YG+ ++ +    K + +        K    T 
Sbjct: 411 SKSDLRSNDFSI-VGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTA 469

Query: 446 VNSIDKWSRMFFPITFSLFNVVYWLYYV 473
              ID ++R  FP  F  FNV+YW  Y+
Sbjct: 470 AKRIDLYARALFPFCFLFFNVIYWSIYL 497


>gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3
           precursor [Homo sapiens]
          Length = 515

 Score =  275 bits (702), Expect = 9e-74
 Identities = 169/489 (34%), Positives = 250/489 (51%), Gaps = 99/489 (20%)

Query: 41  VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
           ++ LL+GYD +LRPD G  P  +   + V SI  V+ +NM+YT+ ++F Q+W D+RL ++
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                L L++ +  ++W+PDT+F N KK+  H +T  NRM+R+  DG VLY LR+T  A 
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 161 CMMDLRRYPLDEQNCTLEIESY-------------------------------------- 182
           C + L  +P+DE +C LE  S+                                      
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249

Query: 183 --GYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240
             GY  ++I + W      V       L QFS V  +  ++ V+ T+G Y  +S+ F L 
Sbjct: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 309

Query: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300
           R +GYF +QTY+P TLI +LSWVSFWIN DA  AR +LGITTVLTMTT+ST  R++LPK+
Sbjct: 310 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKV 369

Query: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ 360
            YV A+D+++  CF+FVF AL+EY  ++Y    + P K      D+   +KN L +    
Sbjct: 370 SYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSK------DKDKKKKNPL-LRMFS 422

Query: 361 VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYG-RALD 419
             A       T++IR  +             AT+   ++  +Q R      E YG   LD
Sbjct: 423 FKA------PTIDIRPRS-------------ATIQMNNATHLQERD-----EEYGYECLD 458

Query: 420 --------------RHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFN 465
                         R G    GRI  R +++             D ++R+FFP  F LFN
Sbjct: 459 GKDCASFFCCFEDCRTGAWRHGRIHIRIAKM-------------DSYARIFFPTAFCLFN 505

Query: 466 VVYWLYYVH 474
           +VYW+ Y++
Sbjct: 506 LVYWVSYLY 514


>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
           [Homo sapiens]
          Length = 554

 Score =  274 bits (700), Expect = 1e-73
 Identities = 175/524 (33%), Positives = 264/524 (50%), Gaps = 69/524 (13%)

Query: 18  MITMVCCAHSTNEPSNMSYVKETV---------DRLLKGYDIRLRPDFGGPPVDVGMRID 68
           ++  +C A   NE    +  +E +         D LL GYD RLRP FGGP  +V   I 
Sbjct: 20  LLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIY 79

Query: 69  VASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKK 128
           V S   VS+V M+YT+ ++F+Q+W DKRL Y G    L L+N +  ++W PDT+F N KK
Sbjct: 80  VTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKK 139

Query: 129 SFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDD 188
           S  H +T  N++ R+  +GT+LY +R+T +A C M L  +P+D   C L+  SY Y   +
Sbjct: 140 SVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSE 199

Query: 189 IEFYWNGGEGAVTGVNK--IELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYF 246
           + + W  G      V K    L Q+ ++   + S+ ++  TG Y  +++ F L+R +GYF
Sbjct: 200 MIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYF 259

Query: 247 ILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAI 306
           ++QTY+P  +  ILS VSFWIN ++  AR   GITTVLTMTT+S   R +LPK+ Y  A+
Sbjct: 260 MIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAM 319

Query: 307 DIYLMGCFVFVFLALLEYAFVNYIF----------FGKGPQKKGASKQDQSANEKNKLEM 356
           D ++  CF FVF AL+E+A VNY              K PQ+  A+   +  + +  L+ 
Sbjct: 320 DWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQN 379

Query: 357 NKVQVD--AHGNILL-------STLEIRNETSGSEVLTSVSDPKATMYSYDSAS------ 401
               ++     N L+       +  E+ N +S S  +   S  K T  SY ++S      
Sbjct: 380 TNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESS-KGTPRSYLASSPNPFSR 438

Query: 402 ------------IQYRKPLSSREAY-------GRALDRHGVPSK-GRIRRRASQL----- 436
                       +    P S R  Y       G A  RH   S+  RI+   + +     
Sbjct: 439 ANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGK 498

Query: 437 -------KVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYV 473
                      P  +  + IDK++R+ FP+TF  FN+VYW+ Y+
Sbjct: 499 LSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYL 542


>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
           precursor [Homo sapiens]
          Length = 462

 Score =  273 bits (698), Expect = 2e-73
 Identities = 150/444 (33%), Positives = 232/444 (52%), Gaps = 40/444 (9%)

Query: 33  NMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSW 92
           N++     +D LL GYD RLRP  G     V   I V S   VS+  M+YT+ ++F+QSW
Sbjct: 45  NITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSW 104

Query: 93  KDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152
           KD+RL + G    L L+N +A ++W PDT+F N KKS  H +T  N+++RL  DGT+LY 
Sbjct: 105 KDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYT 164

Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGG--EGAVTGVNKIELPQ 210
           +R+T +A C M L  +P+D   C L+  SY Y   ++ + W  G  +  V   +   L Q
Sbjct: 165 MRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQ 224

Query: 211 FSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYD 270
           + ++   + ++ +  +TG Y  ++  F LKR IGYF++QTY+P  +  ILS VSFW+N +
Sbjct: 225 YHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 284

Query: 271 ASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYI 330
           +  AR   G+TTVLTMTT+S   R +LPK+ Y  A+D ++  C+ FVF AL+E+A VNY 
Sbjct: 285 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF 344

Query: 331 FFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDP 390
                  K+G +   + A E  K++  +  +        +T ++ +  +  +  T     
Sbjct: 345 ------TKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTS 398

Query: 391 KATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSID 450
             T  S   +     K   S++ Y                               ++ ID
Sbjct: 399 NTTSVSVKPSE---EKTSESKKTY-----------------------------NSISKID 426

Query: 451 KWSRMFFPITFSLFNVVYWLYYVH 474
           K SR+ FP+ F  FN+VYW  Y++
Sbjct: 427 KMSRIVFPVLFGTFNLVYWATYLN 450


>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
           [Homo sapiens]
          Length = 467

 Score =  271 bits (693), Expect = 9e-73
 Identities = 150/438 (34%), Positives = 237/438 (54%), Gaps = 26/438 (5%)

Query: 41  VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
           +++LL+ YD +LRPD G  P  + + I V SI  VS +NM+Y + ++F Q+W D RL ++
Sbjct: 51  LNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFN 110

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                LTL++ +   +W+PDT F N K +  H +T  N+++R+  DG +LY LR+T  A 
Sbjct: 111 STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170

Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVS 220
           C + L  +P+DE +C L   SYGY  +++ + W              L QF  +  +  +
Sbjct: 171 CQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTT 230

Query: 221 KKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGI 280
           + V  + G Y  +++ F L R +GYF +QTY+P  L  +LSWVSFWI  DA+ AR ALGI
Sbjct: 231 EIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGI 290

Query: 281 TTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKG 340
           TTVLTMTT+ST  R++LP++ YV A+D+++  CF+FVF AL+EYA +NY       +K  
Sbjct: 291 TTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYY---SSCRKPT 347

Query: 341 ASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSA 400
            +K+  S    +       ++        S L++R   +    L +      ++Y  +  
Sbjct: 348 TTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNN------SVYWQEFE 401

Query: 401 SIQYRKPLSSREAYG----RALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMF 456
                + L  ++           + G   KGRI               D+  +D +SR+F
Sbjct: 402 DTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIH-------------IDILELDSYSRVF 448

Query: 457 FPITFSLFNVVYWLYYVH 474
           FP +F LFN+VYW+ Y++
Sbjct: 449 FPTSFLLFNLVYWVGYLY 466


>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
           [Homo sapiens]
          Length = 492

 Score =  271 bits (692), Expect = 1e-72
 Identities = 160/456 (35%), Positives = 242/456 (53%), Gaps = 52/456 (11%)

Query: 33  NMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSW 92
           N++     +DRLL GYD RLRP  G    +V   I V S   VS+ +M+YT+ ++F+Q+W
Sbjct: 63  NITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTW 122

Query: 93  KDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152
            D+RL + G    L L+N +A ++W PDT+F N KKS  H +T  N+++RL  +GT+LY 
Sbjct: 123 HDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYT 182

Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGV--NKIELPQ 210
           +R+T  A C M L  +P+D   C L+  SY YTT ++ + W  G+     V  +   L Q
Sbjct: 183 MRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQ 242

Query: 211 FSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYD 270
           + ++ + + ++ +  +TG Y  ++  F LKR IGYF++QTY+P  +  ILS VSFW+N +
Sbjct: 243 YDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 302

Query: 271 ASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYI 330
           +  AR   G+TTVLTMTT+S   R +LPK+ Y  A+D ++  C+ FVF AL+E+A VNY 
Sbjct: 303 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF 362

Query: 331 ------FFGKG-PQKKGASKQDQSA-NEKNKLEMNKVQVDAHGNIL----LSTLEIRNET 378
                 + GK  P+     K+  +A  +K     N V      N+      ST+      
Sbjct: 363 TKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAP 422

Query: 379 SGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKV 438
           S S   T ++ PKAT Y  DS +                                     
Sbjct: 423 SASSTPTIIASPKAT-YVQDSPT------------------------------------- 444

Query: 439 KIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
           +      V+ +DK SR+ FP+ F++FN+VYW  YV+
Sbjct: 445 ETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN 480


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,173,925
Number of Sequences: 37866
Number of extensions: 641473
Number of successful extensions: 1610
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1443
Number of HSP's gapped (non-prelim): 101
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.