Search of human proteins with 11321640

Search of human proteins with 11321640

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11321640 basic beta 1 syntrophin [Homo sapiens]
         (538 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11321640 basic beta 1 syntrophin [Homo sapiens]                   1074   0.0  
gi|5803177 basic beta 2 syntrophin [Homo sapiens]                     587   e-167
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]                   496   e-140
gi|9507165 syntrophin, gamma 2 [Homo sapiens]                         156   5e-38
gi|9507163 syntrophin, gamma 1 [Homo sapiens]                         115   1e-25
gi|9966877 golgi associated PDZ and coiled-coil motif containing...    83   6e-16
gi|62868213 golgi associated PDZ and coiled-coil motif containin...    83   6e-16
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           70   6e-12
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           70   6e-12
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    67   3e-11
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    65   2e-10
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    65   2e-10
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...    64   3e-10
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    64   3e-10
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...    64   5e-10
gi|8922944 lin-7 homolog C [Homo sapiens]                              63   8e-10
gi|11545920 lin-7 homolog B [Homo sapiens]                             63   8e-10
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      62   1e-09
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      62   1e-09
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       62   1e-09
gi|4759306 lin-7 homolog A [Homo sapiens]                              61   2e-09
gi|218505835 membrane-associated guanylate kinase-related  3 iso...    61   3e-09
gi|148746189 multiple PDZ domain protein [Homo sapiens]                60   4e-09
gi|45827729 scribble isoform b [Homo sapiens]                          60   4e-09
gi|45827731 scribble isoform a [Homo sapiens]                          60   4e-09
gi|112382257 InaD-like [Homo sapiens]                                  60   5e-09
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    60   5e-09
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]           57   4e-08
gi|13376349 PDZ domain containing 7 [Homo sapiens]                     57   4e-08
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]         56   9e-08

>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
          Length = 538

 Score = 1074 bits (2777), Expect = 0.0
 Identities = 538/538 (100%), Positives = 538/538 (100%)

Query: 1   MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGI 60
           MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGI
Sbjct: 1   MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGI 60

Query: 61  GTATNGSFCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQEL 120
           GTATNGSFCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQEL
Sbjct: 61  GTATNGSFCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQEL 120

Query: 121 GGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQAL 180
           GGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQAL
Sbjct: 121 GGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQAL 180

Query: 181 KRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRD 240
           KRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRD
Sbjct: 181 KRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRD 240

Query: 241 RKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDL 300
           RKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDL
Sbjct: 241 RKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDL 300

Query: 301 LTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMP 360
           LTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMP
Sbjct: 301 LTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMP 360

Query: 361 RRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRD 420
           RRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRD
Sbjct: 361 RRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRD 420

Query: 421 LSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQ 480
           LSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQ
Sbjct: 421 LSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQ 480

Query: 481 SPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA 538
           SPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA
Sbjct: 481 SPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA 538


>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
          Length = 540

 Score =  587 bits (1512), Expect = e-167
 Identities = 310/556 (55%), Positives = 398/556 (71%), Gaps = 38/556 (6%)

Query: 1   MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAA----- 55
           +A A AAA AGPA A   RA ++GL+E+L+R+RW +V+  LS ++L L+ +  AA     
Sbjct: 3   VAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELEPA 62

Query: 56  ------AYNGI------GTATNGSFCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVP 103
                 A+NG+      G +  GS  RG G   P A    PP  PAG   A         
Sbjct: 63  LGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPA----PPRGPAGEAGA--------- 109

Query: 104 ESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSV 163
              S   R V+V+KQE GGLGISIKGG+EN+MPILISKIF GLAADQ++AL +GDAILSV
Sbjct: 110 ---SPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSV 166

Query: 164 NGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLG 223
           NG DLR ATHD+AVQALKRAGKEVLLEVK++RE TPY+KK S VS++ WE   P+SP   
Sbjct: 167 NGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFS 226

Query: 224 GSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDS 283
           GS  D  S +  +  +DRK IPLKMC+  R++++ D ENR +E+HSPD+++T+ILR KD+
Sbjct: 227 GS-EDSGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDT 285

Query: 284 ATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAG-SREIRHLGWLAEKVPGES-KKQW 341
           ATA +WF AIH+N+  LL +V+AE+   LG T  AG S+E++H+ WLAE+   +  ++QW
Sbjct: 286 ATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQW 345

Query: 342 KPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATR 401
           +P L+ +TEKDLL+YD MP  ++AW SP H+YPL+ATRLVHSG G  SP  G DL+FATR
Sbjct: 346 RPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATR 405

Query: 402 TGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYEN 461
           TG+RQGIE HLFR ET RDLS WTR +VQGCH +AELI E+S  C    QE RLTIHYEN
Sbjct: 406 TGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYEN 465

Query: 462 GFSITTEPQEGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVF 521
           GF+I+ E   G     + + P+E+LKMS+DDGIR LYLDFGG +GE+ +DLHSCPKPIVF
Sbjct: 466 GFTISRE--NGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVF 523

Query: 522 IIHSFLSAKITRLGLV 537
           ++H+FLSAK+TR+GL+
Sbjct: 524 VLHTFLSAKVTRMGLL 539


>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
          Length = 505

 Score =  496 bits (1277), Expect = e-140
 Identities = 269/532 (50%), Positives = 355/532 (66%), Gaps = 36/532 (6%)

Query: 15  AGGGRAQRSGLLEVLVR-------DRWHKVLVNLSEDALVLSSEEGAAAYNGIGTATNGS 67
           A G RA R+GLLE+          +RW +VL++L+ED L +S  +G       G      
Sbjct: 2   ASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEP-GAPREQE 60

Query: 68  FCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISI 127
             +  GA  PGAG                  P Q+PE++  Q+R V V K + GGLGISI
Sbjct: 61  PAQLNGAAEPGAG------------------PPQLPEALLLQRRRVTVRKADAGGLGISI 102

Query: 128 KGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEV 187
           KGG+ENKMPILISKIFKGLAADQT+AL+VGDAILSVNG DL  ATHDEAVQ LK+ GKEV
Sbjct: 103 KGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEV 162

Query: 188 LLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLK 247
           +LEVKYM++ +PY K  +  + +GW++ PP SP     +S  P+ ++FS   + K + LK
Sbjct: 163 VLEVKYMKDVSPYFKNSTGGTSVGWDS-PPASPLQRQPSSPGPTPRNFS---EAKHMSLK 218

Query: 248 MCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDLLTRVIAE 307
           M YV++     DPE R LEI S D + T+ LR+KD A+A++W +AI + VN L  RV  E
Sbjct: 219 MAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDE 278

Query: 308 VREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWF 367
           ++  L  T  AGS++I+ +GWL E++P        P L +LTEK+LL+Y S+P  +EA  
Sbjct: 279 LQALLAATSTAGSQDIKQIGWLTEQLPSGGT---APTLALLTEKELLLYLSLPETREALS 335

Query: 368 SPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRS 427
            P  T PL+ATRLVHSGP KGS     +LSFA RTGTR G++THLF  E+ ++L+ WTR 
Sbjct: 336 RPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQ 395

Query: 428 IVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSI-TTEPQEGAFPKTIIQSPYEKL 486
           +V GCH +AE + E+STACT+  + C L++H + GF++   EP  GA    +++ P+EKL
Sbjct: 396 LVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEP--GAARAVLLRQPFEKL 453

Query: 487 KMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA 538
           +MSSDDG  +L+LDFGG +GEIQLDLHSCPK IVFIIHSFLSAK+TRLGL+A
Sbjct: 454 QMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGLLA 505


>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
          Length = 539

 Score =  156 bits (394), Expect = 5e-38
 Identities = 124/457 (27%), Positives = 217/457 (47%), Gaps = 44/457 (9%)

Query: 110 KRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLR 169
           +R V + +Q +GGLG+SIKGG E+ +P++ISKIF+  AADQT  L+VGDA+L VNG  + 
Sbjct: 71  RRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVE 130

Query: 170 DATHDEAVQALKRAGKEVLLEVKYMREATPYVK--KGSP----VSEIGWETPPPES--PR 221
           +ATH+E V  L+ AG EV + V+Y+REA  ++K   GSP        G  +P  +S    
Sbjct: 131 NATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHL 190

Query: 222 LGGSTSDPPSSQSFSFHRDRK---------SIPLKMCYVTRSMALADPEN-RQLEIHSPD 271
            G S++  PSS S    +D +         S+PL M  ++R  A  +       E+ + D
Sbjct: 191 NGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLALD 250

Query: 272 AKHTVILRSKDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSREIRHLGWLAE 331
              + ILR   +     W  A+ +N+ +L  +       ++     + S ++ H+GW+ E
Sbjct: 251 GVSSGILRFYTAQDGTDWLRAVSANIRELTLQ-----NMKMANKCCSPSDQVVHMGWVNE 305

Query: 332 KVPG-ESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATR-------LVHS 383
           K+ G +S + ++P  + L      ++ + P     W     TY L           L   
Sbjct: 306 KLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWLTED 365

Query: 384 GPGKGSPQAGV-DLSFATRTGTRQGI-----ETHLFRAETSRDLSHWTRSIVQGCHNSAE 437
              + +   G+ D  F  +      I     ++H+F  E   +L+ W +S  +      +
Sbjct: 366 CWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFMEVQ 425

Query: 438 LIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDG---I 494
                +  C+++ +    T+ +  GF+      E      + +  + +LK SSDDG   +
Sbjct: 426 RTGSRTYMCSWQGEMLCFTVDFALGFTCF----ESKTKNVLWRFKFSQLKGSSDDGKTRV 481

Query: 495 RMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKI 531
           ++L+ +   K  E++       + ++  IHSF++AK+
Sbjct: 482 KLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKV 518


>gi|9507163 syntrophin, gamma 1 [Homo sapiens]
          Length = 517

 Score =  115 bits (287), Expect = 1e-25
 Identities = 113/459 (24%), Positives = 195/459 (42%), Gaps = 45/459 (9%)

Query: 104 ESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSV 163
           E   + +R V + +Q +GG G+SIKGG E+ +P+++SKI K   A+ +  L++GDAIL +
Sbjct: 49  EPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQI 108

Query: 164 NGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVK-----------------KGSP 206
           NG ++R   H+E VQ L+ AG+EV L V +++ A  ++K                   SP
Sbjct: 109 NGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSP 168

Query: 207 VSEIGWETPPPESPRLGGSTSDPPSSQSFSFHR---DRKSIPLKMCYVTRSMALAD-PEN 262
           + + G       +     S S  P+S    + +   D + IPL     ++ +   D    
Sbjct: 169 LCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQ 228

Query: 263 RQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSRE 322
              ++ + D   T I++   +     W  AI +N+++L    I ++           +++
Sbjct: 229 NAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINR-----NFPVNQQ 283

Query: 323 IRHLGWL-AEKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHT---YPLLAT 378
           I ++GW  A +      + + P  + L    L  + + P     W     T   Y ++  
Sbjct: 284 IVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCK 343

Query: 379 RLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAEL 438
            L  S          +D      T   +  E   F  E   DL+ W R+         E 
Sbjct: 344 ILKDSDL--------LDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVER 395

Query: 439 IAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDG---IR 495
           I   + AC  ++    LTI +  GF       + A    + +  + +LK SSDDG   I+
Sbjct: 396 IQCKTYACVLESHLMGLTIDFSTGFICF----DAATKAVLWRYKFSQLKGSSDDGKSKIK 451

Query: 496 MLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRL 534
            L+ +   K  E +    S    ++  IHSF +AK+  L
Sbjct: 452 FLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACL 490


>gi|9966877 golgi associated PDZ and coiled-coil motif containing
           isoform a [Homo sapiens]
          Length = 462

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 45/84 (53%), Positives = 58/84 (69%)

Query: 111 RGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
           R V +LK++  GLGISI GGKE+ +PILIS+I  G  AD+   L+VGDAIL+VNG +LRD
Sbjct: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346

Query: 171 ATHDEAVQALKRAGKEVLLEVKYM 194
             H EAV  L +   E+  EV Y+
Sbjct: 347 TKHKEAVTILSQQRGEIEFEVVYV 370


>gi|62868213 golgi associated PDZ and coiled-coil motif containing
           isoform b [Homo sapiens]
          Length = 454

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 45/84 (53%), Positives = 58/84 (69%)

Query: 111 RGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
           R V +LK++  GLGISI GGKE+ +PILIS+I  G  AD+   L+VGDAIL+VNG +LRD
Sbjct: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338

Query: 171 ATHDEAVQALKRAGKEVLLEVKYM 194
             H EAV  L +   E+  EV Y+
Sbjct: 339 TKHKEAVTILSQQRGEIEFEVVYV 362


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 53/133 (39%), Positives = 66/133 (49%), Gaps = 17/133 (12%)

Query: 82  AQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENK-----MP 136
           A PP  P  V T   + P  V  + ++ +     L++   GLG SI GG +N        
Sbjct: 195 ANPP--PVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSS 252

Query: 137 ILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMRE 196
           I I+KI  G AA Q   L V D IL VN  D+RD TH +AV+ALK AG  V L       
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRL------- 305

Query: 197 ATPYVKKGSPVSE 209
              YVK+  PVSE
Sbjct: 306 ---YVKRRKPVSE 315



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 46/122 (37%), Positives = 67/122 (54%), Gaps = 8/122 (6%)

Query: 77  PGAGGAQPPDSPAGVRTAFTDLPEQV--PESISNQKRGVKVLKQELGGLGISIKGGKENK 134
           P +   Q P SPA     ++ + + V   + I+ + R V VL +   GLG +I GG++ +
Sbjct: 433 PSSFLGQTPASPA----RYSPVSKAVLGDDEITREPRKV-VLHRGSTGLGFNIVGGEDGE 487

Query: 135 MPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYM 194
             I IS I  G  AD +  L  GD I+SVN  DLR A+H++A  ALK AG+ V +  +Y 
Sbjct: 488 -GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546

Query: 195 RE 196
            E
Sbjct: 547 PE 548



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 35/91 (38%), Positives = 51/91 (56%), Gaps = 6/91 (6%)

Query: 106 ISNQKRGVKVLKQELGGLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAI 160
           +S +   +K++K   G LG SI GG  N+       I ++KI +G AA +   L +GD +
Sbjct: 313 VSEKIMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371

Query: 161 LSVNGADLRDATHDEAVQALKRAGKEVLLEV 191
           L+VN   L + TH+EAV ALK     V L+V
Sbjct: 372 LAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 53/133 (39%), Positives = 66/133 (49%), Gaps = 17/133 (12%)

Query: 82  AQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENK-----MP 136
           A PP  P  V T   + P  V  + ++ +     L++   GLG SI GG +N        
Sbjct: 195 ANPP--PVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSS 252

Query: 137 ILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMRE 196
           I I+KI  G AA Q   L V D IL VN  D+RD TH +AV+ALK AG  V L       
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRL------- 305

Query: 197 ATPYVKKGSPVSE 209
              YVK+  PVSE
Sbjct: 306 ---YVKRRKPVSE 315



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 46/122 (37%), Positives = 67/122 (54%), Gaps = 8/122 (6%)

Query: 77  PGAGGAQPPDSPAGVRTAFTDLPEQV--PESISNQKRGVKVLKQELGGLGISIKGGKENK 134
           P +   Q P SPA     ++ + + V   + I+ + R V VL +   GLG +I GG++ +
Sbjct: 433 PSSFLGQTPASPA----RYSPVSKAVLGDDEITREPRKV-VLHRGSTGLGFNIVGGEDGE 487

Query: 135 MPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYM 194
             I IS I  G  AD +  L  GD I+SVN  DLR A+H++A  ALK AG+ V +  +Y 
Sbjct: 488 -GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546

Query: 195 RE 196
            E
Sbjct: 547 PE 548



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 35/91 (38%), Positives = 51/91 (56%), Gaps = 6/91 (6%)

Query: 106 ISNQKRGVKVLKQELGGLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAI 160
           +S +   +K++K   G LG SI GG  N+       I ++KI +G AA +   L +GD +
Sbjct: 313 VSEKIMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371

Query: 161 LSVNGADLRDATHDEAVQALKRAGKEVLLEV 191
           L+VN   L + TH+EAV ALK     V L+V
Sbjct: 372 LAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 44/115 (38%), Positives = 66/115 (57%), Gaps = 7/115 (6%)

Query: 84  PPDSPAGVRTAFTDLPEQV--PESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISK 141
           PP  P    T ++ +P  +   E  + + R + +L +   GLG +I GG++ +  I +S 
Sbjct: 359 PPQVPP---TRYSPIPRHMLAEEDFTREPRKI-ILHKGSTGLGFNIVGGEDGE-GIFVSF 413

Query: 142 IFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMRE 196
           I  G  AD +  L  GD ILSVNG +LR+ATH++A  ALKRAG+ V +  +Y  E
Sbjct: 414 ILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPE 468



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 48/125 (38%), Positives = 59/125 (47%), Gaps = 6/125 (4%)

Query: 73  GAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKE 132
           G   P   G+ P   P    T   D  EQV  S    K    VL++   GLG SI GG +
Sbjct: 92  GKSTPKLNGSGPSWWPECTCTN-RDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGID 150

Query: 133 N-KMP----ILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEV 187
           N  +P    I I+KI  G AA     L V D +L VN  D+ +  H  AV+ALK AG  V
Sbjct: 151 NPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVV 210

Query: 188 LLEVK 192
            L V+
Sbjct: 211 RLVVR 215



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 32/75 (42%), Positives = 44/75 (58%), Gaps = 5/75 (6%)

Query: 122 GLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEA 176
           GLG SI GG  N+       I I+KI +G AA +   L +GD +L+VN  +L+D  H+EA
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294

Query: 177 VQALKRAGKEVLLEV 191
           V +LK     V L+V
Sbjct: 295 VASLKNTSDMVYLKV 309


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 46/115 (40%), Positives = 63/115 (54%), Gaps = 4/115 (3%)

Query: 82  AQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISK 141
           A  P SP        DL  +  E I  + R + V+ +   GLG +I GG++ +  I IS 
Sbjct: 328 AMTPTSPRRYSPVAKDLLGE--EDIPREPRRI-VIHRGSTGLGFNIVGGEDGE-GIFISF 383

Query: 142 IFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMRE 196
           I  G  AD +  L  GD ILSVNG DLR+A+H++A  ALK AG+ V +  +Y  E
Sbjct: 384 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPE 438



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 42/92 (45%), Positives = 50/92 (54%), Gaps = 7/92 (7%)

Query: 116 LKQELGGLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
           L++   GLG SI GG +N        I I+KI  G AA Q   L V D+IL VN  D+R+
Sbjct: 111 LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 170

Query: 171 ATHDEAVQALKRAGKEVLLEVKYMREATPYVK 202
            TH  AV+ALK AG  V L V  MR   P  K
Sbjct: 171 VTHSAAVEALKEAGSIVRLYV--MRRKPPAEK 200



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 32/75 (42%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 122 GLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEA 176
           GLG SI GG  N+       I ++KI +G AA +   L +GD IL+VN   L D  H++A
Sbjct: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271

Query: 177 VQALKRAGKEVLLEV 191
           V ALK     V L+V
Sbjct: 272 VAALKNTYDVVYLKV 286


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 46/115 (40%), Positives = 63/115 (54%), Gaps = 4/115 (3%)

Query: 82  AQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISK 141
           A  P SP        DL  +  E I  + R + V+ +   GLG +I GG++ +  I IS 
Sbjct: 282 AMTPTSPRRYSPVAKDLLGE--EDIPREPRRI-VIHRGSTGLGFNIVGGEDGE-GIFISF 337

Query: 142 IFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMRE 196
           I  G  AD +  L  GD ILSVNG DLR+A+H++A  ALK AG+ V +  +Y  E
Sbjct: 338 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPE 392



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 48/125 (38%), Positives = 59/125 (47%), Gaps = 7/125 (5%)

Query: 83  QPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKM-----PI 137
           Q    P  V T   + P  V  +    +     L++   GLG SI GG +N        I
Sbjct: 32  QANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSI 91

Query: 138 LISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREA 197
            I+KI  G AA Q   L V D+IL VN  D+R+ TH  AV+ALK AG  V L V  MR  
Sbjct: 92  FITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYV--MRRK 149

Query: 198 TPYVK 202
            P  K
Sbjct: 150 PPAEK 154



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 32/75 (42%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 122 GLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEA 176
           GLG SI GG  N+       I ++KI +G AA +   L +GD IL+VN   L D  H++A
Sbjct: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225

Query: 177 VQALKRAGKEVLLEV 191
           V ALK     V L+V
Sbjct: 226 VAALKNTYDVVYLKV 240


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 37/82 (45%), Positives = 52/82 (63%), Gaps = 1/82 (1%)

Query: 115 VLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHD 174
           +L +   GLG +I GG++ +  I +S I  G  AD +  L  GD ILSVNG +LR+ATH+
Sbjct: 51  ILHKGSTGLGFNIVGGEDGE-GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHE 109

Query: 175 EAVQALKRAGKEVLLEVKYMRE 196
           +A  ALKRAG+ V +  +Y  E
Sbjct: 110 QAAAALKRAGQSVTIVAQYRPE 131


>gi|122937249 glutamate receptor interacting protein 2 [Homo
           sapiens]
          Length = 1141

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 54/164 (32%), Positives = 74/164 (45%), Gaps = 35/164 (21%)

Query: 104 ESISNQKRGVKV---LKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAI 160
           +SI  + RG+ V   +K+E   LG++I GG +      +S +  G  A ++  L +GD I
Sbjct: 134 QSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYI 193

Query: 161 LSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPP--- 217
            SVNG  L    HDE +  LK  G+ V+LEV+Y                   E PPP   
Sbjct: 194 RSVNGIHLTRLRHDEIITLLKNVGERVVLEVEY-------------------ELPPPAPE 234

Query: 218 ESPRLGGSTSDP---PSSQSFSF------HRD-RKSIPLKMCYV 251
            +PR+   T D        SF F      H D  KS PL + YV
Sbjct: 235 NNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYV 278



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 38/109 (34%), Positives = 58/109 (53%)

Query: 116 LKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDE 175
           LK+  G LGI+I G +E   PI+IS + K   A++T A++VGD IL++N   L+     E
Sbjct: 757 LKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSE 816

Query: 176 AVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGG 224
           A+  L+ AG+ V L++K   +     +K   +SE       P     GG
Sbjct: 817 AIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGG 865



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 33/100 (33%), Positives = 52/100 (52%), Gaps = 8/100 (8%)

Query: 99  PEQVPESISNQKRGVKV-LKQELGGLGISIKGGKEN----KMPILISKIFKGLAADQTQA 153
           PE  P  IS   + V V L +E    G  ++GG         P++++ +  G  AD+  +
Sbjct: 233 PENNPRIIS---KTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGS 289

Query: 154 LYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKY 193
           L VGD +LSV+G  L  A+H  A+  L++   E L +V+Y
Sbjct: 290 LKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEY 329



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 28/80 (35%), Positives = 43/80 (53%), Gaps = 6/80 (7%)

Query: 120 LGGLGISIKGG----KENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDE 175
           L G G+ ++GG    +    P L+  I     A++   L VGD +LS+NG    D T +E
Sbjct: 562 LSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621

Query: 176 AVQALKRA--GKEVLLEVKY 193
           A Q L+ A    +V+LEV++
Sbjct: 622 ANQLLRDAALAHKVVLEVEF 641



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 26/81 (32%), Positives = 45/81 (55%), Gaps = 1/81 (1%)

Query: 113 VKVLKQELGGLGISIKGGKENK-MPILISKIFKGLAADQTQALYVGDAILSVNGADLRDA 171
           VK+ K+    LGI+I      +  P++IS I KG  A +T  L  GD +L+++   L + 
Sbjct: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715

Query: 172 THDEAVQALKRAGKEVLLEVK 192
             ++AVQ L++    V L+++
Sbjct: 716 PMEDAVQILRQCEDLVKLKIR 736



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/92 (30%), Positives = 48/92 (52%), Gaps = 3/92 (3%)

Query: 103 PESISNQKRG--VKVLKQELGGLGISIKGGK-ENKMPILISKIFKGLAADQTQALYVGDA 159
           P++++N      V+++K     LGIS+      NK  I I +I      D++ AL+ GD 
Sbjct: 334 PDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDH 393

Query: 160 ILSVNGADLRDATHDEAVQALKRAGKEVLLEV 191
           ILS++G  +   +  EA + L    ++V LE+
Sbjct: 394 ILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425


>gi|223890252 glutamate receptor interacting protein 1 [Homo
           sapiens]
          Length = 1076

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 43/129 (33%), Positives = 66/129 (51%), Gaps = 9/129 (6%)

Query: 79  AGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPIL 138
           A   +PPD    VR       + +PE        V+++K+E   LG+++ GG +      
Sbjct: 27  ASQTKPPDGALAVRR------QSIPEEFKGSTV-VELMKKEGTTLGLTVSGGIDKDGKPR 79

Query: 139 ISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREAT 198
           +S + +G  A ++  L VGD I +VNG +L    HDE +  LK  G+ V+LEV+Y  E  
Sbjct: 80  VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEY--ELP 137

Query: 199 PYVKKGSPV 207
           P   +GS V
Sbjct: 138 PVSVQGSSV 146



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 40/121 (33%), Positives = 66/121 (54%), Gaps = 11/121 (9%)

Query: 116 LKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDE 175
           LK+  G LGI+I G +E   PI+IS + KG  A++T A+++GD IL++N + L+     E
Sbjct: 624 LKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSE 683

Query: 176 AVQALKRAGKEVLLEVKYMREAT--------PYVKKGSPVSEIGWETPPPESPRLGGSTS 227
           A+  L+ AG+ V L++K   +A         P     S + ++  ++ P + P   G  S
Sbjct: 684 AIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKP---GKLS 740

Query: 228 D 228
           D
Sbjct: 741 D 741



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 34/102 (33%), Positives = 53/102 (51%), Gaps = 5/102 (4%)

Query: 97  DLPEQVPESISNQKRGVKV-LKQELGGLGISIKGG----KENKMPILISKIFKGLAADQT 151
           +LP    +  S   R V+V L +E    G  I+GG    +    P++I+ +  G  AD+ 
Sbjct: 135 ELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADRE 194

Query: 152 QALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKY 193
             +  GD +LSV+G  L   TH EA+  LK+ G+E  L ++Y
Sbjct: 195 GTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEY 236



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/171 (28%), Positives = 70/171 (40%), Gaps = 22/171 (12%)

Query: 113 VKVLKQELGGLGISIKGGKE-NKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDA 171
           V+V K     LG+++      NK  I+I KI     AD+  AL+VGD ILS++G  +   
Sbjct: 253 VEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYC 312

Query: 172 THDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPS 231
           T  EA Q L     +V LE+      T    KG            P+   L  S+  P S
Sbjct: 313 TLAEATQFLANTTDQVKLEI-LPHHQTRLALKG------------PDHAALVSSSFSPTS 359

Query: 232 SQSFSFHRDRKSIPLKMCYVTRSMALADPENRQL--EIHSPDAKHTVILRS 280
             ++S         L M  + RS+    P    +   +   D K ++ L S
Sbjct: 360 MSAYSLS------SLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLAS 404



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 2/82 (2%)

Query: 113 VKVLKQELGGLGISIKGGKENKM--PILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
           VK+ K+    LGI+I      K   P++IS I KG  A +T  L +GD +L+++   L +
Sbjct: 522 VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581

Query: 171 ATHDEAVQALKRAGKEVLLEVK 192
            + ++AVQ L++    V L+++
Sbjct: 582 CSMEDAVQILQQCEDLVKLKIR 603



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 6/78 (7%)

Query: 122 GLGISIKGG----KENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAV 177
           G GI ++G     +    P LIS I     A++   L +GD ++++NG    D+T +EA 
Sbjct: 430 GFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEAS 489

Query: 178 QALKRAG--KEVLLEVKY 193
           Q L+ +    +V LE+++
Sbjct: 490 QLLRDSSITSKVTLEIEF 507


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 34/72 (47%), Positives = 44/72 (61%)

Query: 122 GLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALK 181
           GLG +I GGKE   PI IS+I  G  AD+   L  GD +LSVNG  +    H++AV+ LK
Sbjct: 102 GLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLK 161

Query: 182 RAGKEVLLEVKY 193
            A  +V L V+Y
Sbjct: 162 AAQGKVKLVVRY 173


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 33/72 (45%), Positives = 43/72 (59%)

Query: 122 GLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALK 181
           GLG +I GGKE   PI IS++  G  AD+   L  GD +LSVNG  +    H++AV+ LK
Sbjct: 102 GLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLK 161

Query: 182 RAGKEVLLEVKY 193
            A   V L V+Y
Sbjct: 162 AAQGSVKLVVRY 173


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 40/92 (43%), Positives = 55/92 (59%), Gaps = 2/92 (2%)

Query: 105 SISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVN 164
           S+  + R V VL +   GLG +I GG++ +  I +S I  G  AD +  L  GD ILSVN
Sbjct: 311 SLEGEPRKV-VLHKGSTGLGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVN 368

Query: 165 GADLRDATHDEAVQALKRAGKEVLLEVKYMRE 196
           G DLR A+H++A  ALK AG+ V +  +Y  E
Sbjct: 369 GIDLRGASHEQAAAALKGAGQTVTIIAQYQPE 400



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 36/85 (42%), Positives = 47/85 (55%), Gaps = 5/85 (5%)

Query: 116 LKQELGGLGISIKGGKEN-----KMPILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
           L++   GLG SI GG +N        I I+KI  G AA +   L V D IL VN  D+ +
Sbjct: 50  LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 109

Query: 171 ATHDEAVQALKRAGKEVLLEVKYMR 195
            +H +AV+ALK AG  V L V+  R
Sbjct: 110 VSHSKAVEALKEAGSIVRLYVRRRR 134



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 47/128 (36%), Positives = 60/128 (46%), Gaps = 23/128 (17%)

Query: 122 GLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEA 176
           GLG SI GG  N+       I ++KI  G AA +   L VGD +L VN   L + TH+EA
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210

Query: 177 VQALKRAGKEVLLEVK-----YMREATPYVKKGSPVSEIGWETPPPESPRLGGS------ 225
           V  LK   + V L+V      YM +  PY     P       +PP E+  L G+      
Sbjct: 211 VAILKNTSEVVYLKVGKPTTIYMTD--PY----GPPDITHSYSPPMENHLLSGNNGTLEY 264

Query: 226 -TSDPPSS 232
            TS PP S
Sbjct: 265 KTSLPPIS 272


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 40/92 (43%), Positives = 55/92 (59%), Gaps = 2/92 (2%)

Query: 105 SISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVN 164
           S+  + R V VL +   GLG +I GG++ +  I +S I  G  AD +  L  GD ILSVN
Sbjct: 519 SLEGEPRKV-VLHKGSTGLGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVN 576

Query: 165 GADLRDATHDEAVQALKRAGKEVLLEVKYMRE 196
           G DLR A+H++A  ALK AG+ V +  +Y  E
Sbjct: 577 GIDLRGASHEQAAAALKGAGQTVTIIAQYQPE 608



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 36/85 (42%), Positives = 47/85 (55%), Gaps = 5/85 (5%)

Query: 116 LKQELGGLGISIKGGKEN-----KMPILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
           L++   GLG SI GG +N        I I+KI  G AA +   L V D IL VN  D+ +
Sbjct: 206 LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 265

Query: 171 ATHDEAVQALKRAGKEVLLEVKYMR 195
            +H +AV+ALK AG  V L V+  R
Sbjct: 266 VSHSKAVEALKEAGSIVRLYVRRRR 290



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 47/128 (36%), Positives = 60/128 (46%), Gaps = 23/128 (17%)

Query: 122 GLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEA 176
           GLG SI GG  N+       I ++KI  G AA +   L VGD +L VN   L + TH+EA
Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366

Query: 177 VQALKRAGKEVLLEVK-----YMREATPYVKKGSPVSEIGWETPPPESPRLGGS------ 225
           V  LK   + V L+V      YM +  PY     P       +PP E+  L G+      
Sbjct: 367 VAILKNTSEVVYLKVGKPTTIYMTD--PY----GPPDITHSYSPPMENHLLSGNNGTLEY 420

Query: 226 -TSDPPSS 232
            TS PP S
Sbjct: 421 KTSLPPIS 428


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 40/92 (43%), Positives = 55/92 (59%), Gaps = 2/92 (2%)

Query: 105 SISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVN 164
           S+  + R V VL +   GLG +I GG++ +  I +S I  G  AD +  L  GD ILSVN
Sbjct: 414 SLEGEPRKV-VLHKGSTGLGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVN 471

Query: 165 GADLRDATHDEAVQALKRAGKEVLLEVKYMRE 196
           G DLR A+H++A  ALK AG+ V +  +Y  E
Sbjct: 472 GIDLRGASHEQAAAALKGAGQTVTIIAQYQPE 503



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 36/85 (42%), Positives = 47/85 (55%), Gaps = 5/85 (5%)

Query: 116 LKQELGGLGISIKGGKEN-----KMPILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
           L++   GLG SI GG +N        I I+KI  G AA +   L V D IL VN  D+ +
Sbjct: 101 LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 160

Query: 171 ATHDEAVQALKRAGKEVLLEVKYMR 195
            +H +AV+ALK AG  V L V+  R
Sbjct: 161 VSHSKAVEALKEAGSIVRLYVRRRR 185



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 47/128 (36%), Positives = 60/128 (46%), Gaps = 23/128 (17%)

Query: 122 GLGISIKGGKENKM-----PILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEA 176
           GLG SI GG  N+       I ++KI  G AA +   L VGD +L VN   L + TH+EA
Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261

Query: 177 VQALKRAGKEVLLEVK-----YMREATPYVKKGSPVSEIGWETPPPESPRLGGS------ 225
           V  LK   + V L+V      YM +  PY     P       +PP E+  L G+      
Sbjct: 262 VAILKNTSEVVYLKVGKPTTIYMTD--PY----GPPDITHSYSPPMENHLLSGNNGTLEY 315

Query: 226 -TSDPPSS 232
            TS PP S
Sbjct: 316 KTSLPPIS 323


>gi|4759306 lin-7 homolog A [Homo sapiens]
          Length = 233

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 32/72 (44%), Positives = 43/72 (59%)

Query: 122 GLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALK 181
           GLG ++ GGKE   PI IS+I  G  A++   L  GD +LSVNG  +    H++AV+ LK
Sbjct: 117 GLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLK 176

Query: 182 RAGKEVLLEVKY 193
            A   V L V+Y
Sbjct: 177 AAKDSVKLVVRY 188


>gi|218505835 membrane-associated guanylate kinase-related  3 isoform
            1 [Homo sapiens]
          Length = 1481

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 54/205 (26%), Positives = 93/205 (45%), Gaps = 20/205 (9%)

Query: 108  NQKRGVKVLKQELG--GLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNG 165
            NQ  G   ++ E G  G G S++GGKE  M + I ++ +   A +   ++VGD I+ +NG
Sbjct: 1014 NQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEING 1073

Query: 166  ADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRL--G 223
               +  TH  A++ ++  G +VLL    +R  T  +          W+   P S  +   
Sbjct: 1074 EPTQGITHTRAIELIQAGGNKVLL---LLRPGTGLIPDHG-----DWDINNPSSSNVIYD 1125

Query: 224  GSTSDPPSSQSFSFHRD------RKSIPLKMCYVTRSMALADPENRQ-LEIHSPDAKHTV 276
              +  PPSS   S   +       +S+ +++C     +    PE +  L  + P+ KH  
Sbjct: 1126 EQSPLPPSSHFASIFEESHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQS 1185

Query: 277  ILRSKDSATAQAWFSAIHSNVNDLL 301
            +L+ K+ +      S  HSN  +LL
Sbjct: 1186 LLQ-KNVSKRDPPSSHGHSNKKNLL 1209



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 4/83 (4%)

Query: 113 VKVLKQELGGLGISIKGGKENK----MPILISKIFKGLAADQTQALYVGDAILSVNGADL 168
           V + ++E  G G  I   K       +P  I ++ +G  AD+   L VGD I +VNG  +
Sbjct: 852 VVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSI 911

Query: 169 RDATHDEAVQALKRAGKEVLLEV 191
            + +HD  VQ +K AG  V L V
Sbjct: 912 VELSHDNIVQLIKDAGVTVTLTV 934



 Score = 34.3 bits (77), Expect = 0.30
 Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 3/74 (4%)

Query: 108 NQKRGVKV---LKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVN 164
           +Q +GV V   LK+   G G +I GG      + +  + K   A Q   +  GD I+ +N
Sbjct: 402 SQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDIN 461

Query: 165 GADLRDATHDEAVQ 178
           G  +   TH + VQ
Sbjct: 462 GNCVLGHTHADVVQ 475



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 19/79 (24%), Positives = 37/79 (46%), Gaps = 2/79 (2%)

Query: 116 LKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDE 175
           L+++  G G  + GG      I I  I    AA++   L   D ++ ++G  ++  +H +
Sbjct: 729 LRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQ 788

Query: 176 AVQALKRAGK--EVLLEVK 192
            +  +  A +   VLL V+
Sbjct: 789 VLDLMTTAARNGHVLLTVR 807


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 34/80 (42%), Positives = 50/80 (62%), Gaps = 3/80 (3%)

Query: 122  GLGISIKGGKENKM-PILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQAL 180
            GLG+SI GG +  +  I+I ++++  AA +   L+ GD IL VNG DLR ATHDEA+  L
Sbjct: 1638 GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697

Query: 181  KRAGKEVLLEVKYMREATPY 200
            ++  + V L +   R+  PY
Sbjct: 1698 RQTPQRVRLTL--YRDEAPY 1715



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 34/94 (36%), Positives = 53/94 (56%), Gaps = 9/94 (9%)

Query: 108  NQKRGVKVLKQELGGLGISIKGGK---------ENKMPILISKIFKGLAADQTQALYVGD 158
            NQ R V++ ++    LGISI GG+         E    I I  + +   A +   L  GD
Sbjct: 1147 NQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGD 1206

Query: 159  AILSVNGADLRDATHDEAVQALKRAGKEVLLEVK 192
             I+ V+G DLRDA+H++AV+A+++AG  V+  V+
Sbjct: 1207 RIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 31/73 (42%), Positives = 38/73 (52%), Gaps = 3/73 (4%)

Query: 122  GLGISIKGG---KENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQ 178
            GLG SI GG       +PI +  +F   AA +   L  GD I++VNG  L   TH+EAV 
Sbjct: 1967 GLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVA 2026

Query: 179  ALKRAGKEVLLEV 191
             LKR    V L V
Sbjct: 2027 ILKRTKGTVTLMV 2039



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 32/73 (43%), Positives = 43/73 (58%), Gaps = 2/73 (2%)

Query: 113  VKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDAT 172
            +++ K+   GLG+SI G K N   + +S I KG  AD    L  GD IL VNG D+R+AT
Sbjct: 1726 IELQKKPGKGLGLSIVG-KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT 1784

Query: 173  HDEAVQALKRAGK 185
              EAV AL +  +
Sbjct: 1785 -QEAVAALLKVSE 1796



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 45/152 (29%), Positives = 68/152 (44%), Gaps = 9/152 (5%)

Query: 44  DALVLSSEEGAAAYNGIGTATNGSFCRGAGAGH--PGAGGAQPPDSPAGVRTAFTDLPEQ 101
           D   +SSE+ A      G        RGA      P A G     SP        D   Q
Sbjct: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368

Query: 102 VPESISNQKRGVKVLKQELGGLGISIKG--GKENKMP--ILISKIFKGLAADQTQALYVG 157
             E   ++   V++ K  + GLGI+I G  G +   P  I +  I K  A +    + +G
Sbjct: 369 KGEE--SETFDVELTKN-VQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIG 425

Query: 158 DAILSVNGADLRDATHDEAVQALKRAGKEVLL 189
           D I++V+G +L+  T+ +AV+ L+  G+ VLL
Sbjct: 426 DQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLL 457



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/84 (36%), Positives = 44/84 (52%), Gaps = 3/84 (3%)

Query: 111  RGVKVLKQELGGLGISIKGGKENKM---PILISKIFKGLAADQTQALYVGDAILSVNGAD 167
            R V++ K     LGISI GG  + +   PI I+ +     A QTQ L VGD I+++ G  
Sbjct: 1832 RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891

Query: 168  LRDATHDEAVQALKRAGKEVLLEV 191
                TH +AV  LK A   + ++V
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQV 1915



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 31/109 (28%), Positives = 55/109 (50%), Gaps = 6/109 (5%)

Query: 81  GAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELG--GLGISIKGGKENKMP-- 136
           G+   + P    T      E+V   ++  + G++ ++ E G  GLG SI   ++   P  
Sbjct: 666 GSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPAS 725

Query: 137 --ILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRA 183
             I+I  +  G  A++   L  GD ++ VN  +L +++ +EAV+ALK A
Sbjct: 726 TVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774



 Score = 30.0 bits (66), Expect = 5.6
 Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 3/71 (4%)

Query: 119 ELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQ 178
           E  GLGIS++    +     I  +        +  L+ GD +L VNG  L    H + V 
Sbjct: 561 ENSGLGISLEATVGHHF---IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVN 617

Query: 179 ALKRAGKEVLL 189
            LK    EV +
Sbjct: 618 ILKELPIEVTM 628



 Score = 29.6 bits (65), Expect = 7.3
 Identities = 16/60 (26%), Positives = 31/60 (51%), Gaps = 1/60 (1%)

Query: 123  LGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKR 182
            LG+++   K+  + +++  I  G A  +   + +GD ILS+N       T+ +A   L+R
Sbjct: 1018 LGMTVSANKDG-LGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRR 1076


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 52/158 (32%), Positives = 73/158 (46%), Gaps = 15/158 (9%)

Query: 87  SPAGVRTAFTDLPEQVPESISN-QKRGVKVLKQELGGLGISIKGGKENK------MPILI 139
           SP   R     LP   PES    ++R V  L +   GLG SI GGK +         I +
Sbjct: 835 SPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFV 894

Query: 140 SKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREA-- 197
           S+I +G AA +   L VGD +LS+NG D+ +A HD AV  L  A   + L ++  REA  
Sbjct: 895 SRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLE--REAGG 952

Query: 198 ----TPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPS 231
               +P      P + +   +    +P + G  S  PS
Sbjct: 953 PLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 38/81 (46%), Positives = 48/81 (59%), Gaps = 11/81 (13%)

Query: 121  GGLGISIKGGKENKMP--------ILISKIF-KGLAADQTQALYVGDAILSVNGADLRDA 171
            G LG+SI GG ++           + ISK+  +GLAA     L VGD IL+VNG D+RDA
Sbjct: 1012 GPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAA--RSGLRVGDRILAVNGQDVRDA 1069

Query: 172  THDEAVQALKRAGKEVLLEVK 192
            TH EAV AL R   E+ L V+
Sbjct: 1070 THQEAVSALLRPCLELSLLVR 1090



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 39/103 (37%), Positives = 55/103 (53%), Gaps = 8/103 (7%)

Query: 103 PESISNQKRGVKVLKQELGGLGISIKGGKENKM------PILISKIFKGLAADQTQALYV 156
           P  I  ++  + +L+Q  GGLGISI GGK +         I IS++ +   A +   + V
Sbjct: 719 PARIEEEELTLTILRQT-GGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRV 776

Query: 157 GDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATP 199
           GD +L VNG  L+ A H EAV+AL+ AG  V + V   R   P
Sbjct: 777 GDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819



 Score = 37.7 bits (86), Expect = 0.027
 Identities = 28/71 (39%), Positives = 33/71 (46%), Gaps = 9/71 (12%)

Query: 123  LGISIKGGKENKMP---------ILISKIFKGLAADQTQALYVGDAILSVNGADLRDATH 173
            LGISI+GG               I ISK+    AA +   L VG  +L VN   L   TH
Sbjct: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170

Query: 174  DEAVQALKRAG 184
             EAVQ L+  G
Sbjct: 1171 GEAVQLLRSVG 1181


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 52/158 (32%), Positives = 73/158 (46%), Gaps = 15/158 (9%)

Query: 87  SPAGVRTAFTDLPEQVPESISN-QKRGVKVLKQELGGLGISIKGGKENK------MPILI 139
           SP   R     LP   PES    ++R V  L +   GLG SI GGK +         I +
Sbjct: 835 SPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFV 894

Query: 140 SKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREA-- 197
           S+I +G AA +   L VGD +LS+NG D+ +A HD AV  L  A   + L ++  REA  
Sbjct: 895 SRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLE--REAGG 952

Query: 198 ----TPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPS 231
               +P      P + +   +    +P + G  S  PS
Sbjct: 953 PLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 38/81 (46%), Positives = 48/81 (59%), Gaps = 11/81 (13%)

Query: 121  GGLGISIKGGKENKMP--------ILISKIF-KGLAADQTQALYVGDAILSVNGADLRDA 171
            G LG+SI GG ++           + ISK+  +GLAA     L VGD IL+VNG D+RDA
Sbjct: 1012 GPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAA--RSGLRVGDRILAVNGQDVRDA 1069

Query: 172  THDEAVQALKRAGKEVLLEVK 192
            TH EAV AL R   E+ L V+
Sbjct: 1070 THQEAVSALLRPCLELSLLVR 1090



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 39/103 (37%), Positives = 55/103 (53%), Gaps = 8/103 (7%)

Query: 103 PESISNQKRGVKVLKQELGGLGISIKGGKENKM------PILISKIFKGLAADQTQALYV 156
           P  I  ++  + +L+Q  GGLGISI GGK +         I IS++ +   A +   + V
Sbjct: 719 PARIEEEELTLTILRQT-GGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRV 776

Query: 157 GDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATP 199
           GD +L VNG  L+ A H EAV+AL+ AG  V + V   R   P
Sbjct: 777 GDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819



 Score = 37.7 bits (86), Expect = 0.027
 Identities = 28/71 (39%), Positives = 33/71 (46%), Gaps = 9/71 (12%)

Query: 123  LGISIKGGKENKMP---------ILISKIFKGLAADQTQALYVGDAILSVNGADLRDATH 173
            LGISI+GG               I ISK+    AA +   L VG  +L VN   L   TH
Sbjct: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170

Query: 174  DEAVQALKRAG 184
             EAVQ L+  G
Sbjct: 1171 GEAVQLLRSVG 1181


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 34/77 (44%), Positives = 53/77 (68%), Gaps = 2/77 (2%)

Query: 122  GLGISIKGGKENKM-PILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQAL 180
            GLG+SI GGK+  +  I+I ++++  AA +   L+ GD IL VNG DLR+++H+EA+ AL
Sbjct: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505

Query: 181  KRAGKEVLLEVKYMREA 197
            ++  ++V L V Y  EA
Sbjct: 1506 RQTPQKVRL-VVYRDEA 1521



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 38/100 (38%), Positives = 57/100 (57%), Gaps = 10/100 (10%)

Query: 111  RGVKVLKQELGGLGISIKGGK---------ENKMPILISKIFKGLAADQTQALYVGDAIL 161
            R V++ ++    LGISI GG+         E    I I ++ +   A +T AL  GD IL
Sbjct: 1067 RIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKIL 1126

Query: 162  SVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYV 201
             V+G DL++A+H EAV+A+K AG  V+  V+ +  +TP V
Sbjct: 1127 EVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSL-SSTPRV 1165



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 37/83 (44%), Positives = 47/83 (56%), Gaps = 1/83 (1%)

Query: 113  VKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDAT 172
            V + K+   GLG+SI G K N   + IS I KG AAD    L  GD ILSVNG D+R+A+
Sbjct: 1534 VDLQKKAGRGLGLSIVG-KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNAS 1592

Query: 173  HDEAVQALKRAGKEVLLEVKYMR 195
             +     LK A   V LE+  +R
Sbjct: 1593 QETVATILKCAQGLVQLEIGRLR 1615



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/96 (34%), Positives = 51/96 (53%), Gaps = 3/96 (3%)

Query: 99   PEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKM---PILISKIFKGLAADQTQALY 155
            P Q       + R V++ ++    LGISI GG+ + +   P+ I+ I     A +TQ L 
Sbjct: 1663 PSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLK 1722

Query: 156  VGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEV 191
            VGD I+S+NG  L   +H + V  LK A   ++L+V
Sbjct: 1723 VGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 49/200 (24%), Positives = 81/200 (40%), Gaps = 28/200 (14%)

Query: 91   VRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKE-NKMPILISKIFKGLAAD 149
            +R  + DLP ++          +  L+++  GLG+S+ G K+ ++M I +  I     A 
Sbjct: 1226 IRQRYADLPGELH---------IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAA 1276

Query: 150  QTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLL------EVKYMREATPY-VK 202
                + +GD +L +N   L   +H  A   +K A  +V L      +       TP+ V 
Sbjct: 1277 ADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP 1336

Query: 203  KGSPVSEIGWETPPPESPRLGGST----SDPPSSQSFSF---HRDRKSIPLKMCYVTRSM 255
              SP S        P S    GS        P S+SF        ++  P K+ + ++ +
Sbjct: 1337 SSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEI 1396

Query: 256  ALADPENRQLEIHSPDAKHT 275
             LA   +     HS DA  T
Sbjct: 1397 PLAPASS----YHSTDADFT 1412



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 50/213 (23%), Positives = 88/213 (41%), Gaps = 18/213 (8%)

Query: 17  GGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGIGTATNGSFCRGAGAGH 76
           GG A R G L+         +L     +   ++SE+ A      G +      R   A  
Sbjct: 278 GGLADRDGRLQT-----GDHILKIGGTNVQGMTSEQVAQVLRNCGNSV-----RMLVARD 327

Query: 77  PGAGGAQPPDSPAGVRTAFTDLPEQVPESISN--QKRGVKVLKQELGGLGISIKG----- 129
           P    +  P +PA +  A   +  + P S S+  +   V++++++   LGI I G     
Sbjct: 328 PAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTS 387

Query: 130 GKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLL 189
                  I +  I  G AA     + V D I++V+G +++   + + V+ L+ AG+ V L
Sbjct: 388 HTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL 447

Query: 190 EVKYMREATPYVKKGSPVSEIGWETPPPESPRL 222
            +   R+ +       P S+ G    P + P L
Sbjct: 448 TL-VRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 2/70 (2%)

Query: 122 GLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALK 181
           GLG  I GGK +   +++  I  G  AD+   L  GD IL + G +++  T ++  Q L+
Sbjct: 257 GLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314

Query: 182 RAGKEVLLEV 191
             G  V + V
Sbjct: 315 NCGNSVRMLV 324


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 8/110 (7%)

Query: 122  GLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALK 181
            G G SI+GG+E KM + + ++ +   A +   + VGD I+ +NG   RD TH  A++ +K
Sbjct: 1156 GFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215

Query: 182  RAGKEVLLEVKYMREATPYVKKGSPVSEIGWETP---PPESPRLGGSTSD 228
              G+ V L +K      P   + +P     W +P    P  P +G S  D
Sbjct: 1216 SGGRRVRLLLKRGTGQVPEYDEPAP-----WSSPAAAAPGLPEVGVSLDD 1260



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 40/140 (28%), Positives = 64/140 (45%), Gaps = 15/140 (10%)

Query: 105  SISNQKRGVKVLKQELGGLGISI-------KGGKENKMPILISKIFKGLAADQTQALYVG 157
            S S Q   V + ++E  G G  I       + G    +P  I +I  G  AD+   L VG
Sbjct: 913  SHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVG 972

Query: 158  DAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMRE-----ATPYVKKGSPVSEIGW 212
            D IL+VNG  + +  H + V+ +K AG  V L +    E     + P  +K SP+++   
Sbjct: 973  DRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQ--- 1029

Query: 213  ETPPPESPRLGGSTSDPPSS 232
            ++P  +   L   +   P+S
Sbjct: 1030 QSPLAQQSPLAQPSPATPNS 1049



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 33/117 (28%), Positives = 50/117 (42%), Gaps = 12/117 (10%)

Query: 116 LKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDE 175
           L++   G G  I GG E   PILI  +    +AD+   L+ GD ++ V+G  +   TH  
Sbjct: 781 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840

Query: 176 AVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSS 232
            +  +  A +   + +   R+              G E P PE+ R  GS S   SS
Sbjct: 841 VIDLMHHAARNGQVNLTVRRKVL-----------CGGE-PCPENGRSPGSVSTHHSS 885


>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
          Length = 1434

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 28/74 (37%), Positives = 49/74 (66%), Gaps = 1/74 (1%)

Query: 113 VKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDAT 172
           V++ K+++GGLG  +K  + +K P++IS + +G AA+Q+  +  GD IL+VNG  L D +
Sbjct: 18  VRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLS 76

Query: 173 HDEAVQALKRAGKE 186
           +D A++ L+    E
Sbjct: 77  YDSALEVLRGIASE 90


>gi|13376349 PDZ domain containing 7 [Homo sapiens]
          Length = 517

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 47/172 (27%), Positives = 75/172 (43%), Gaps = 31/172 (18%)

Query: 59  GIGTATNGSFCRGAGAGHPGAGGAQ----------------PP-----DSPAGVRTAFTD 97
           G+G  ++GS    +  GH G+                    PP      SP G R    +
Sbjct: 13  GLGDLSSGSLSSLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRASSPMG-RVILIN 71

Query: 98  LPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVG 157
            P +     S+    V+V K   G LG S++GG E+ + I +SK+ +G +A++   L VG
Sbjct: 72  SPIEANSDESDIIHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERA-GLCVG 130

Query: 158 DAILSVNGADLRDATHDEAVQALKRAGKEVLL--------EVKYMREATPYV 201
           D I  VNG  L   T   AV+ L  + +  ++         +K+ +E T +V
Sbjct: 131 DKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWV 182



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 32/90 (35%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 123 LGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKR 182
           LG +I+GGKE  + I +SK+  G  A++   + VGD +L+ NG    D +H +AV+ LK 
Sbjct: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEEN-GIKVGDQVLAANGVRFDDISHSQAVEVLK- 279

Query: 183 AGKEVLLEVKYMREATPYVKKGSPVSEIGW 212
               ++L +K   E   Y      VSE  W
Sbjct: 280 GQTHIMLTIK---ETGRYPAYKEMVSEYCW 306


>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
          Length = 1066

 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 37/103 (35%), Positives = 54/103 (52%), Gaps = 11/103 (10%)

Query: 115 VLKQELGGLGISIKGGK--------ENKMPILISKIFKGLAADQTQALYVGDAILSVNGA 166
           VL ++ G LG +I GG+         +   I +SKI     A +   L + D I+ VNG 
Sbjct: 251 VLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGR 310

Query: 167 DLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSE 209
           DL  ATHD+AV+A K A + ++++V      TP  K  +P SE
Sbjct: 311 DLSRATHDQAVEAFKTAKEPIVVQV---LRRTPRTKMFTPPSE 350


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,070,476
Number of Sequences: 37866
Number of extensions: 1079966
Number of successful extensions: 6031
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 81
Number of HSP's that attempted gapping in prelim test: 5553
Number of HSP's gapped (non-prelim): 476
length of query: 538
length of database: 18,247,518
effective HSP length: 107
effective length of query: 431
effective length of database: 14,195,856
effective search space: 6118413936
effective search space used: 6118413936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.