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Search of human proteins with 163792208
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
(709 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 1404 0.0
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 511 e-145
gi|166197690 neuronal guanine nucleotide exchange factor isoform... 324 2e-88
gi|166197688 neuronal guanine nucleotide exchange factor isoform... 324 2e-88
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens] 293 3e-79
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom... 270 4e-72
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens] 248 1e-65
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 109 1e-23
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 109 1e-23
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 108 1e-23
gi|90652857 hypothetical protein LOC84904 [Homo sapiens] 96 1e-19
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 92 2e-18
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 86 1e-16
gi|38373682 pleckstrin homology domain containing family G membe... 85 3e-16
gi|111154084 pleckstrin homology domain containing family G memb... 85 3e-16
gi|111154088 pleckstrin homology domain containing family G memb... 85 3e-16
gi|111154080 pleckstrin homology domain containing family G memb... 85 3e-16
gi|111154078 pleckstrin homology domain containing family G memb... 85 3e-16
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 84 5e-16
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 76 9e-14
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 75 2e-13
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 75 2e-13
gi|222080070 pleckstrin homology domain-containing family G memb... 74 4e-13
gi|222080068 pleckstrin homology domain-containing family G memb... 74 4e-13
gi|222080066 pleckstrin homology domain-containing family G memb... 74 4e-13
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 74 5e-13
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 74 5e-13
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 74 5e-13
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 74 6e-13
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 73 8e-13
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 1404 bits (3633), Expect = 0.0
Identities = 709/709 (100%), Positives = 709/709 (100%)
Query: 1 MAQRHSDSSLEEKLLGHRFHSELRLDAGGNPASGLPMVRGSPRVRDDAAFQPQVPAPPQP 60
MAQRHSDSSLEEKLLGHRFHSELRLDAGGNPASGLPMVRGSPRVRDDAAFQPQVPAPPQP
Sbjct: 1 MAQRHSDSSLEEKLLGHRFHSELRLDAGGNPASGLPMVRGSPRVRDDAAFQPQVPAPPQP 60
Query: 61 RPPGHEEPWPIVLSTESPAALKLGTQQLIPKSLAVASKAKTPARHQSFGAAVLSREAARR 120
RPPGHEEPWPIVLSTESPAALKLGTQQLIPKSLAVASKAKTPARHQSFGAAVLSREAARR
Sbjct: 61 RPPGHEEPWPIVLSTESPAALKLGTQQLIPKSLAVASKAKTPARHQSFGAAVLSREAARR 120
Query: 121 DPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKGLGKPGGQGDAIQLSPKLQAL 180
DPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKGLGKPGGQGDAIQLSPKLQAL
Sbjct: 121 DPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKGLGKPGGQGDAIQLSPKLQAL 180
Query: 181 AEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQERGLNTSQESDDDILDESSS 240
AEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQERGLNTSQESDDDILDESSS
Sbjct: 181 AEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQERGLNTSQESDDDILDESSS 240
Query: 241 PEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQ 300
PEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQ
Sbjct: 241 PEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQ 300
Query: 301 HSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDIS 360
HSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDIS
Sbjct: 301 HSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDIS 360
Query: 361 DILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFL 420
DILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFL
Sbjct: 361 DILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFL 420
Query: 421 ILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYT 480
ILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYT
Sbjct: 421 ILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYT 480
Query: 481 LHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKK 540
LHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKK
Sbjct: 481 LHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKK 540
Query: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLL 600
KSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLL
Sbjct: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLL 600
Query: 601 SSDSASDRARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQ 660
SSDSASDRARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQ
Sbjct: 601 SSDSASDRARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQ 660
Query: 661 QEDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRMERLRVETDV 709
QEDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRMERLRVETDV
Sbjct: 661 QEDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRMERLRVETDV 709
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 511 bits (1316), Expect = e-145
Identities = 313/676 (46%), Positives = 420/676 (62%), Gaps = 44/676 (6%)
Query: 58 PQPRPPGHE----EPWPIVLSTESPAALKLGTQQLIPKSLAVASK-AKTPARHQSFGAAV 112
P R P E E +VLST SPAALK+G QQ+IPKSLA K +K+ ++ +
Sbjct: 216 PLQRLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRL 275
Query: 113 LSREAARRDPKLLPAP---SFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKG---LGKPGG 166
L R + L P + ++D D D G LRR LR+ SYR A+ P
Sbjct: 276 LK---VRSMVEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTS 332
Query: 167 QGDAIQLS-PKLQALAEEPSQPHTRSPAKNKKTLGRKRGHKGSF--KDDPQLYQEIQERG 223
++S P L+ + E+ + + K K G+ G+F +++ LYQ +E+
Sbjct: 333 SKKKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQ-----GTFDGEENAVLYQNYKEKA 387
Query: 224 LNTSQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEER 283
L+ DE S P+ QK D IV+ ++P + TWSQL V G+ +S EER
Sbjct: 388 LDIDS-------DEESEPK-EQKSDEKIVIH-HKPLRSTWSQLSAVKRKGLSQTVSQEER 438
Query: 284 KRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFF 343
KRQEA+FE+++SE SY SL IL+ F SKEL T+T+ E HHLFSNI DV AS++FF
Sbjct: 439 KRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFF 498
Query: 344 EDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALR 403
+LE RH+ + ++DISDI+E+H F PY+ YC+NEVYQQRTLQKL+++N +F+E L
Sbjct: 499 IELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLS 558
Query: 404 EIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVR 463
IE C LPM+SFLILPMQRVTRLPLLMDT+C KT S +Y+ RALK +SKLVR
Sbjct: 559 RIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVR 618
Query: 464 QCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGEL-FLVEETGLFRKIAS 522
CNEGA +MER E MYT+++QL+F K+K PL+S+SRWL+KRGEL VE+T LF + S
Sbjct: 619 LCNEGARKMERTEMMYTINSQLEF-KIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTS 677
Query: 523 RPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGN-------R 575
+ Y FLFNDVL++TKKKSEESY V DY+ + + VE + EL G N R
Sbjct: 678 KQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSR 737
Query: 576 SSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQWQGLSSKGDLPQVE 635
SS H F +T+L N + ++LL +++ S+RARWI AL HS + + + L QVE
Sbjct: 738 QSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHS--SGKPPADRTSLTQVE 795
Query: 636 ITKAFFAKQADEVTLQQADVVLVLQQ-EDGWLYGERLRDGETGWFPEDFARFITSRVAVE 694
I ++F AKQ DE++LQ ADVVL+ Q+ DGW GERLRDGE GWFP + A+ IT + ++
Sbjct: 796 IVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQATID 855
Query: 695 GNVRRMER-LRVETDV 709
NV RM R L +ET+V
Sbjct: 856 KNVERMGRLLGLETNV 871
>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 618
Score = 324 bits (831), Expect = 2e-88
Identities = 179/487 (36%), Positives = 287/487 (58%), Gaps = 17/487 (3%)
Query: 228 QESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQE 287
+E +++ +E +SP + + ++ + W LPE+ G+L+ L EE K QE
Sbjct: 125 EEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQE 184
Query: 288 AMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLE 347
AMFE++TSE SY SL++LV F++++ +R + E H LFSN+LDVL S+RF +LE
Sbjct: 185 AMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELE 244
Query: 348 QRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIER 407
R + +++ D+ DI+ +A HF YI Y SN+ YQ+RT ++L+ AAFRE + ++E
Sbjct: 245 HRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLEL 304
Query: 408 RPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNE 467
P C GLP SFLILP QR+TRL LL+ + + + SER A A K + +V+ CNE
Sbjct: 305 DPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNE 364
Query: 468 GAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRP--- 524
G +M R EQM ++ +++F K+KS+P+IS SRWLLK+GEL + R + ++
Sbjct: 365 GVRKMSRTEQMISIQKKMEF-KIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFH 423
Query: 525 TCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQ 584
YLFLFND+LV+ ++ + Y V D A ++VE++E ++ ++ + F
Sbjct: 424 EIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELE----------DQGQTLANVFI 473
Query: 585 VTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSER-QWQGLSSK-GDLPQVEITKAFFA 642
+ LL N++ R+ +L + S S+ RW+ +L + R ++ +S+ D PQV+ + A
Sbjct: 474 LRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVA 533
Query: 643 KQADEVTLQQADVVLVLQQ-EDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRME 701
+Q DE+TL+ AD++ +L + +DGW++GERL D E GWFP I + N++
Sbjct: 534 QQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECF 593
Query: 702 RLRVETD 708
R+ D
Sbjct: 594 RVHKMDD 600
>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 710
Score = 324 bits (831), Expect = 2e-88
Identities = 179/487 (36%), Positives = 287/487 (58%), Gaps = 17/487 (3%)
Query: 228 QESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQE 287
+E +++ +E +SP + + ++ + W LPE+ G+L+ L EE K QE
Sbjct: 217 EEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQE 276
Query: 288 AMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLE 347
AMFE++TSE SY SL++LV F++++ +R + E H LFSN+LDVL S+RF +LE
Sbjct: 277 AMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELE 336
Query: 348 QRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIER 407
R + +++ D+ DI+ +A HF YI Y SN+ YQ+RT ++L+ AAFRE + ++E
Sbjct: 337 HRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLEL 396
Query: 408 RPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNE 467
P C GLP SFLILP QR+TRL LL+ + + + SER A A K + +V+ CNE
Sbjct: 397 DPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNE 456
Query: 468 GAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRP--- 524
G +M R EQM ++ +++F K+KS+P+IS SRWLLK+GEL + R + ++
Sbjct: 457 GVRKMSRTEQMISIQKKMEF-KIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFH 515
Query: 525 TCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQ 584
YLFLFND+LV+ ++ + Y V D A ++VE++E ++ ++ + F
Sbjct: 516 EIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELE----------DQGQTLANVFI 565
Query: 585 VTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSER-QWQGLSSK-GDLPQVEITKAFFA 642
+ LL N++ R+ +L + S S+ RW+ +L + R ++ +S+ D PQV+ + A
Sbjct: 566 LRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVA 625
Query: 643 KQADEVTLQQADVVLVLQQ-EDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRME 701
+Q DE+TL+ AD++ +L + +DGW++GERL D E GWFP I + N++
Sbjct: 626 QQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECF 685
Query: 702 RLRVETD 708
R+ D
Sbjct: 686 RVHKMDD 692
>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
Length = 1597
Score = 293 bits (751), Expect = 3e-79
Identities = 196/578 (33%), Positives = 302/578 (52%), Gaps = 41/578 (7%)
Query: 143 GMLRRNLRNQSYRAAMKGLGKPGGQGDAIQLSPKLQALAEEPSQPHTRSPAKNKKTLGRK 202
G R+ LR R ++ G +G A++ P PS K K+ +G
Sbjct: 1034 GWSRQGLR----RPSILPEGSSDSRGPAVEKHPG-------PSDTVVFREKKPKEVMGGF 1082
Query: 203 RGHKGSFKDDPQL-YQEIQERGLNTSQESDDDI--LDESSSPEGTQKVDATIVVK----- 254
+ QL YQE + LN +S + L E+ P ++ +V
Sbjct: 1083 SRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQ 1142
Query: 255 --SYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQ 312
S + W ++P V +L ++ E++K QE FE++ SE SY SL+I V+ F
Sbjct: 1143 RLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQL 1202
Query: 313 SKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFH 372
S LRAT++ EH LFS + DV S F DLE+ + + + D++ HA
Sbjct: 1203 STSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRR 1262
Query: 373 PYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPL 432
Y+ Y +N+ YQ+RT Q L++SN+ FRE L ++E P C L + SFLILP QR+TRL L
Sbjct: 1263 VYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKL 1322
Query: 433 LMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKS 492
L+ + +TQ S A++A A+ +L+R CN M R E++ L +++F + K
Sbjct: 1323 LLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEF-ECKI 1381
Query: 493 LPLISASRWLLKRGELFLVE---ETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQ 549
PLIS SRWL+K GEL +E GL RK+ +RP +L LFND L++++ + ++V
Sbjct: 1382 FPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPV-HLHLFNDCLLLSRPREGSRFLVF 1440
Query: 550 DYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHP--FQVTLLRNSEGRQEQLLLSSDSASD 607
D+A + I+ EK E+ L G PH F++ L +N++G Q + L +++ S+
Sbjct: 1441 DHAPFSSIRGEK---CEMKLHG--------PHKNLFRLFLRQNTQGAQAEFLFRTETQSE 1489
Query: 608 RARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQQ-EDGWL 666
+ RWI AL R+ L + PQV+ +A+ ++ DE+ L++ADVV+V QQ DGWL
Sbjct: 1490 KLRWISALA-MPREELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWL 1548
Query: 667 YGERLRDGETGWFPEDFARFITSRVAVEGNVRRMERLR 704
G RL DGE GWFP FI++ N++ R++
Sbjct: 1549 EGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVK 1586
>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
sapiens]
Length = 802
Score = 270 bits (689), Expect = 4e-72
Identities = 185/545 (33%), Positives = 282/545 (51%), Gaps = 34/545 (6%)
Query: 183 EPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQE----RGLNTSQESDDDILDES 238
EP P ++ +R + F + LYQE + R L Q ++ DE+
Sbjct: 264 EPRLDTQEEPPLGSRSTNERR--QSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEA 321
Query: 239 S-SPEGTQKVDATIVVKSYRPAQVT--------WSQLPEVVELGILDQLSTEERKRQEAM 289
+ EG A + S AQ + W +P+V G+L LS + K QEA
Sbjct: 322 EGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAK 381
Query: 290 FEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQR 349
FE++TSE SY HSLS+ V FL S EL + + LFS + +V S+RF +DLEQR
Sbjct: 382 FELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQR 441
Query: 350 HKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRP 409
+A VL + D++ +H Y+ Y +N+ YQ+RT Q+L+ N F L +E P
Sbjct: 442 LEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESP 501
Query: 410 ACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGA 469
C LP+ SFLILP QR+TRL +L++ + +T SE A++A A+ +LV++CN
Sbjct: 502 VCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASV 561
Query: 470 HRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELF----LVEETGLFRKIASRPT 525
M+R E++ L ++ F + K PLIS +RWL++ GEL L K++S+
Sbjct: 562 QSMKRTEELIHLSKKIHF-EGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSK-A 619
Query: 526 CYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQV 585
YL LFND L+++++K + V +A+M +QV + +PG H F +
Sbjct: 620 VYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPG---------HVFLL 670
Query: 586 TLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQ--WQGLSSKGDLPQVEITKAFFAK 643
LL + + + Q LL + + S++ RWI AL S Q + +S D PQV+ + + A
Sbjct: 671 QLL-HGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQVQCVRTYKAL 729
Query: 644 QADEVTLQQADVVLV-LQQEDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRMER 702
DE+TL++ D++ V DGWL G RL DGE GW P+ + I+S A N+R +R
Sbjct: 730 HPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKR 789
Query: 703 LRVET 707
+ T
Sbjct: 790 VTSAT 794
>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
Length = 841
Score = 248 bits (633), Expect = 1e-65
Identities = 146/384 (38%), Positives = 217/384 (56%), Gaps = 21/384 (5%)
Query: 237 ESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSE 296
E SP DA + P W +LP V G+LD LS +ER+ QE++FE++TSE
Sbjct: 370 EDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSE 429
Query: 297 FSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLV 356
SY SL +L + F+ S+ LR T+T +HH LFSN+ V G S+RF L R ++ +
Sbjct: 430 ASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHI 489
Query: 357 EDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPM 416
D+ D++ HA F Y+ Y N+ YQ+ T +L+ +N F LR ++ P C LP+
Sbjct: 490 SDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPL 549
Query: 417 LSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERME 476
SFL+LP QR+TRL +L+ + +T+ S R + A +AL A+SK++ +C+ RM++ E
Sbjct: 550 PSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTE 609
Query: 477 QMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFR---KIASRP---TCYLFL 530
++ L +L F KVK+LPL+S SR L +GEL E G R ASRP L L
Sbjct: 610 ELIRLTQRLRFHKVKALPLVSWSRRLEFQGEL---TELGCRRGGVLFASRPRFTPLCLLL 666
Query: 531 FNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRN 590
F+D+L++T+ KS + V DYA + +Q +++ P P G P F+++LL N
Sbjct: 667 FSDLLLITQPKSGQRLQVLDYAHRSLVQAQQV-----PDPSG-------PPTFRLSLLSN 714
Query: 591 SEGRQEQLLLSSDSASDRARWIVA 614
+GR LL + S SD RW+ A
Sbjct: 715 HQGRPTHRLLQASSLSDMQRWLGA 738
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 109 bits (272), Expect = 1e-23
Identities = 82/291 (28%), Positives = 137/291 (47%), Gaps = 26/291 (8%)
Query: 271 ELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFS 330
+L LD + ERKRQ + E++ +E Y L ++VE F + +T+ E +F
Sbjct: 1169 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1228
Query: 331 NILDVLGASQRFFEDLEQRHKA---QVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRT 387
N +++ ++ + + L R K ++ V+ I DIL H YI +CS ++
Sbjct: 1229 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELS-HMQAYIRFCSCQLNGAAL 1287
Query: 388 LQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSER 447
LQ+ + F+E L+++ P C G+P+ SFL+ PMQR+TR PLL+ ++ T
Sbjct: 1288 LQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHAD 1347
Query: 448 YKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV------KSLPLISASRW 501
+ + AL+ +L Q NEG E +++ + + + SL R
Sbjct: 1348 HSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRK 1407
Query: 502 LLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYA 552
LL G+L+ K S + FLFND L++T YMV+ +A
Sbjct: 1408 LLHSGKLY---------KTKSNKELHGFLFNDFLLLT-------YMVKQFA 1442
Score = 38.5 bits (88), Expect = 0.022
Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 642 AKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPEDFARFI 687
AK+ + + + D++ VL+Q++ W +GE G GWFP+ + + I
Sbjct: 884 AKKDNHLNFSKHDIITVLEQQENWWFGE--VHGGRGWFPKSYVKII 927
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 109 bits (272), Expect = 1e-23
Identities = 82/291 (28%), Positives = 137/291 (47%), Gaps = 26/291 (8%)
Query: 271 ELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFS 330
+L LD + ERKRQ + E++ +E Y L ++VE F + +T+ E +F
Sbjct: 1196 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1255
Query: 331 NILDVLGASQRFFEDLEQRHKA---QVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRT 387
N +++ ++ + + L R K ++ V+ I DIL H YI +CS ++
Sbjct: 1256 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELS-HMQAYIRFCSCQLNGAAL 1314
Query: 388 LQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSER 447
LQ+ + F+E L+++ P C G+P+ SFL+ PMQR+TR PLL+ ++ T
Sbjct: 1315 LQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHAD 1374
Query: 448 YKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV------KSLPLISASRW 501
+ + AL+ +L Q NEG E +++ + + + SL R
Sbjct: 1375 HSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRK 1434
Query: 502 LLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYA 552
LL G+L+ K S + FLFND L++T YMV+ +A
Sbjct: 1435 LLHSGKLY---------KTKSNKELHGFLFNDFLLLT-------YMVKQFA 1469
Score = 38.5 bits (88), Expect = 0.022
Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 642 AKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPEDFARFI 687
AK+ + + + D++ VL+Q++ W +GE G GWFP+ + + I
Sbjct: 911 AKKDNHLNFSKHDIITVLEQQENWWFGE--VHGGRGWFPKSYVKII 954
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 108 bits (271), Expect = 1e-23
Identities = 76/273 (27%), Positives = 132/273 (48%), Gaps = 9/273 (3%)
Query: 271 ELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFS 330
+L +LD L+ ERKRQ + E++ +E +Y + L ++ E F + +T+ E +F
Sbjct: 1224 DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFV 1283
Query: 331 NILDVLGASQRFFEDLEQRHKA---QVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRT 387
N +++ + + + L R K ++ V+ I DIL H PYI +CS ++
Sbjct: 1284 NWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLP-HMQPYIRFCSRQLNGAAL 1342
Query: 388 LQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSER 447
+Q+ F+E ++ + P C G+P+ SF++ PMQRVTR PL++ + T +
Sbjct: 1343 IQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPD 1402
Query: 448 YKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV-KSLPLISASRWLLKRG 506
+ AL+ +L Q NEG E +++ + + + + L S + L R
Sbjct: 1403 HSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRK 1462
Query: 507 ELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK 539
L +G K S Y FLFND L++T+
Sbjct: 1463 FL----HSGKLYKAKSNKELYGFLFNDFLLLTQ 1491
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/68 (29%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 624 GLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPEDF 683
G K + Q + + AK+ + + + DV+ VL+Q+D W +GE G+ GWFP+ +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGE--VQGQKGWFPKSY 965
Query: 684 ARFITSRV 691
+ I+ +
Sbjct: 966 VKLISGPI 973
Score = 40.8 bits (94), Expect = 0.004
Identities = 22/56 (39%), Positives = 32/56 (57%), Gaps = 10/56 (17%)
Query: 640 FFAKQADEVTLQQADVVLVLQQ--------EDGWLYGERLRDGETGWFPEDFARFI 687
F ++ DE+T+Q D+V+V + E GWL GE G+TGWFP ++A I
Sbjct: 751 FESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGEL--KGKTGWFPANYAEKI 804
>gi|90652857 hypothetical protein LOC84904 [Homo sapiens]
Length = 335
Score = 95.9 bits (237), Expect = 1e-19
Identities = 92/349 (26%), Positives = 149/349 (42%), Gaps = 39/349 (11%)
Query: 274 ILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNIL 333
+ +Q + ERKR E+L +E YQ L ++ FL + + T+ E LF +
Sbjct: 12 VQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWE 71
Query: 334 DVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLIS 393
+ GASQ LE Q L E +H Y + +N Q TLQ+ +
Sbjct: 72 LIYGASQELLPYLEGGCWGQGL---------EGFCRHLELYNQFAANSERSQTTLQEQLK 122
Query: 394 SNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASR 453
N FR +R E RP GGL + L LP+QR+ + L+ L T +S ++ +R
Sbjct: 123 KNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTR 182
Query: 454 ALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEE 513
A + IS+ ++ + + + + + + L + K L ++ RW L++G L +V
Sbjct: 183 AARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGL---TSGRWFLRQGWLLVVPP 239
Query: 514 TGLFRKIASRPTCYLFLFNDVLVVTKKK------SEESYMVQDYAQMNHIQVEKIEPSEL 567
G RP + FLF DVL++ K + ++ + M + ++
Sbjct: 240 HG-----EPRPRMF-FLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVF-GHS 292
Query: 568 PLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALT 616
P GG S S PH E+LLL S + +RW +LT
Sbjct: 293 GGPCGGLLSLSFPH--------------EKLLLMSTDQEELSRWYHSLT 327
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 91.7 bits (226), Expect = 2e-18
Identities = 88/360 (24%), Positives = 163/360 (45%), Gaps = 45/360 (12%)
Query: 270 VELGILDQ----LSTEERKRQEAMFEILTSEFSYQHSLSILVEEF---LQSKELRATVTQ 322
+EL LDQ T E+K + E+L +E +Y + L +L + F L + R +
Sbjct: 188 LELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPA 247
Query: 323 MEHHHLFSNILDVLGASQRFF-EDLEQRHKAQVLVEDISDILEEHAE--KHFHPYIAYCS 379
+ +FSNI + +F +LE+R + I DIL++ A K + Y+
Sbjct: 248 EMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFD 307
Query: 380 NEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCL 439
N + + + + I F+ + EI+++ CG L + ++ P+QR+ R +L+
Sbjct: 308 NAMELVKNMTERIPQ---FKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLR 364
Query: 440 KTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISAS 499
K S + A ++L+ IS N +ME ++++ ++ L + +++ S
Sbjct: 365 KLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG----EEEDIVNPS 420
Query: 500 RWLLKRGELFLVEETGLFRKIASRPTC----YLFLFNDVLVVTKKKSEESYMVQDYAQMN 555
L+K G++ K+A+R T YLFLFN++L+ K S + +
Sbjct: 421 NELIKEGQIL---------KLAARNTSAQERYLFLFNNMLLYCVPKF--SLVGSKFTVRT 469
Query: 556 HIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVAL 615
+ ++ ++ E ++ PH FQV+ G++ L L + SA D+ WI AL
Sbjct: 470 RVGIDGMKIVE-------TQNEEYPHTFQVS------GKERTLELQASSAQDKEEWIKAL 516
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 85.9 bits (211), Expect = 1e-16
Identities = 95/394 (24%), Positives = 166/394 (42%), Gaps = 46/394 (11%)
Query: 227 SQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQ 286
SQE D D+ +E E +K R V + E VEL T ++K
Sbjct: 332 SQEVDSDLEEEDDEEEEEEKD---------REIPVPLMERQESVEL-------TVQQKVF 375
Query: 287 EAMFEILTSEFSYQHSLSILVEEF----LQSKELRATVTQMEHHHLFSNILDVLGASQRF 342
E+L +E +Y L +L + F L+ R++ H +FSNI + Q+F
Sbjct: 376 HIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQF 435
Query: 343 F-EDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREA 401
+LE+R + I DIL++ A Y Y N + + F+
Sbjct: 436 LLPELEKRMEEWDRYPRIGDILQKLAP-FLKMYGEYVKNFDRAVELVNTWTERSTQFKVI 494
Query: 402 LREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKL 461
+ E+++ ACG L + ++ P+QR+ R LL+ LK S K A ++L+ I+
Sbjct: 495 IHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATA 554
Query: 462 VRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIA 521
N +MERM ++ ++ L + ++S ++ L+K G + L K
Sbjct: 555 AEHSNAAIRKMERMHKLLKVYELLGGEE----DIVSPTKELIKEGHIL-----KLSAKNG 605
Query: 522 SRPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPH 581
+ YL LFND L+ + + Q ++ I V+ +E E + + ++P
Sbjct: 606 TTQDRYLILFNDRLLYCVPRLR--LLGQKFSVRARIDVDGMELKE-------SSNLNLPR 656
Query: 582 PFQVTLLRNSEGRQEQLLLSSDSASDRARWIVAL 615
F V+ G+Q L L + + ++ W+ A+
Sbjct: 657 TFLVS------GKQRSLELQARTEEEKKDWVQAI 684
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 84.7 bits (208), Expect = 3e-16
Identities = 82/331 (24%), Positives = 151/331 (45%), Gaps = 48/331 (14%)
Query: 276 DQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFL---QSKELRATVTQMEHHHLFSNI 332
++L+ + +QEA++E+L +E SY L +++ FL + + + ++E LFSNI
Sbjct: 328 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 387
Query: 333 LDVLGASQRFFED-----LEQRHKAQVLVEDISDILE--EHAEKHFHPYIAYCSNEVYQQ 385
++ +R + LE+ + + L++ D L+ + F PYI YC E
Sbjct: 388 PEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCM 446
Query: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
++ L+ N FR + E+ P C L + L P QR+T+ PLL+ ++ KT+
Sbjct: 447 EYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE-EP 505
Query: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV--------------- 490
+A + ++ + + N + + +++ + +++D +V
Sbjct: 506 RAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEF 565
Query: 491 ----KSLPLISAS----RWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK--K 540
+ P+ AS R LL G L + E S+ Y FLF D+L+VTK K
Sbjct: 566 LHLDLTAPIPGASPEETRQLLLEGSLRMKEGKD------SKMDVYCFLFTDLLLVTKAVK 619
Query: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPG 571
K+E + +++ + V+KI EL PG
Sbjct: 620 KAERTRVIRP-----PLLVDKIVCRELRDPG 645
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 84.7 bits (208), Expect = 3e-16
Identities = 82/331 (24%), Positives = 151/331 (45%), Gaps = 48/331 (14%)
Query: 276 DQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFL---QSKELRATVTQMEHHHLFSNI 332
++L+ + +QEA++E+L +E SY L +++ FL + + + ++E LFSNI
Sbjct: 405 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 464
Query: 333 LDVLGASQRFFED-----LEQRHKAQVLVEDISDILE--EHAEKHFHPYIAYCSNEVYQQ 385
++ +R + LE+ + + L++ D L+ + F PYI YC E
Sbjct: 465 PEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCM 523
Query: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
++ L+ N FR + E+ P C L + L P QR+T+ PLL+ ++ KT+
Sbjct: 524 EYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE-EP 582
Query: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV--------------- 490
+A + ++ + + N + + +++ + +++D +V
Sbjct: 583 RAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEF 642
Query: 491 ----KSLPLISAS----RWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK--K 540
+ P+ AS R LL G L + E S+ Y FLF D+L+VTK K
Sbjct: 643 LHLDLTAPIPGASPEETRQLLLEGSLRMKEGKD------SKMDVYCFLFTDLLLVTKAVK 696
Query: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPG 571
K+E + +++ + V+KI EL PG
Sbjct: 697 KAERTRVIRP-----PLLVDKIVCRELRDPG 722
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 84.7 bits (208), Expect = 3e-16
Identities = 82/331 (24%), Positives = 151/331 (45%), Gaps = 48/331 (14%)
Query: 276 DQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFL---QSKELRATVTQMEHHHLFSNI 332
++L+ + +QEA++E+L +E SY L +++ FL + + + ++E LFSNI
Sbjct: 328 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 387
Query: 333 LDVLGASQRFFED-----LEQRHKAQVLVEDISDILE--EHAEKHFHPYIAYCSNEVYQQ 385
++ +R + LE+ + + L++ D L+ + F PYI YC E
Sbjct: 388 PEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCM 446
Query: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
++ L+ N FR + E+ P C L + L P QR+T+ PLL+ ++ KT+
Sbjct: 447 EYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE-EP 505
Query: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV--------------- 490
+A + ++ + + N + + +++ + +++D +V
Sbjct: 506 RAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEF 565
Query: 491 ----KSLPLISAS----RWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK--K 540
+ P+ AS R LL G L + E S+ Y FLF D+L+VTK K
Sbjct: 566 LHLDLTAPIPGASPEETRQLLLEGSLRMKEGKD------SKMDVYCFLFTDLLLVTKAVK 619
Query: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPG 571
K+E + +++ + V+KI EL PG
Sbjct: 620 KAERTRVIRP-----PLLVDKIVCRELRDPG 645
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 84.7 bits (208), Expect = 3e-16
Identities = 82/331 (24%), Positives = 151/331 (45%), Gaps = 48/331 (14%)
Query: 276 DQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFL---QSKELRATVTQMEHHHLFSNI 332
++L+ + +QEA++E+L +E SY L +++ FL + + + ++E LFSNI
Sbjct: 328 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 387
Query: 333 LDVLGASQRFFED-----LEQRHKAQVLVEDISDILE--EHAEKHFHPYIAYCSNEVYQQ 385
++ +R + LE+ + + L++ D L+ + F PYI YC E
Sbjct: 388 PEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCM 446
Query: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
++ L+ N FR + E+ P C L + L P QR+T+ PLL+ ++ KT+
Sbjct: 447 EYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE-EP 505
Query: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV--------------- 490
+A + ++ + + N + + +++ + +++D +V
Sbjct: 506 RAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEF 565
Query: 491 ----KSLPLISAS----RWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK--K 540
+ P+ AS R LL G L + E S+ Y FLF D+L+VTK K
Sbjct: 566 LHLDLTAPIPGASPEETRQLLLEGSLRMKEGKD------SKMDVYCFLFTDLLLVTKAVK 619
Query: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPG 571
K+E + +++ + V+KI EL PG
Sbjct: 620 KAERTRVIRP-----PLLVDKIVCRELRDPG 645
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 84.7 bits (208), Expect = 3e-16
Identities = 82/331 (24%), Positives = 151/331 (45%), Gaps = 48/331 (14%)
Query: 276 DQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFL---QSKELRATVTQMEHHHLFSNI 332
++L+ + +QEA++E+L +E SY L +++ FL + + + ++E LFSNI
Sbjct: 384 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 443
Query: 333 LDVLGASQRFFED-----LEQRHKAQVLVEDISDILE--EHAEKHFHPYIAYCSNEVYQQ 385
++ +R + LE+ + + L++ D L+ + F PYI YC E
Sbjct: 444 PEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFGSLFKPYIRYCMEEEGCM 502
Query: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
++ L+ N FR + E+ P C L + L P QR+T+ PLL+ ++ KT+
Sbjct: 503 EYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTE-EP 561
Query: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV--------------- 490
+A + ++ + + N + + +++ + +++D +V
Sbjct: 562 RAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEF 621
Query: 491 ----KSLPLISAS----RWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTK--K 540
+ P+ AS R LL G L + E S+ Y FLF D+L+VTK K
Sbjct: 622 LHLDLTAPIPGASPEETRQLLLEGSLRMKEGKD------SKMDVYCFLFTDLLLVTKAVK 675
Query: 541 KSEESYMVQDYAQMNHIQVEKIEPSELPLPG 571
K+E + +++ + V+KI EL PG
Sbjct: 676 KAERTRVIRP-----PLLVDKIVCRELRDPG 701
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 84.0 bits (206), Expect = 5e-16
Identities = 99/471 (21%), Positives = 187/471 (39%), Gaps = 35/471 (7%)
Query: 94 AVASKAKTPARHQSFGAAVLSREAARRDPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQS 153
++ + P+RH + R PK L PS + +D + + L N+
Sbjct: 599 SILGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPE---PQDSAKLRQSGLANEG 655
Query: 154 YRAAMKGLGKPGGQGDAIQLSPKLQALAEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDP 213
A S + + S+ + A G R F P
Sbjct: 656 TDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPP 715
Query: 214 QLYQEIQERGLNTSQESDDDILDESSSPEGTQKVDATIVVKSYRPAQV----------TW 263
++QE +E + + + E +P+ +K D+ +S + W
Sbjct: 716 PPLDQVQE------EECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNW 769
Query: 264 SQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQM 323
QL V +L L E KRQE + E+ +E ++ +L +L + F Q ++
Sbjct: 770 QQL---VSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPS 826
Query: 324 EHHHLFSNILDVLGASQRFFEDLE---QRHKAQVLVEDISDILEEHA----EKHFHPYIA 376
E +FSN+ D+L E ++ +R++ V+ + D+L + EK H
Sbjct: 827 ELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAAT 886
Query: 377 YCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDT 436
+CSN+ + ++ ++ F+ +++ E P C L + + MQR+T+ PLL+D
Sbjct: 887 FCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDN 946
Query: 437 LCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFS--KVKSLP 494
+ T+ +ER K +A +++ N+ E +++ +LD S K+ P
Sbjct: 947 IAKYTEWPTEREK-VKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYP 1005
Query: 495 LISASRWLLKRGELFLVEETGLFRKIASRPT--CYLFLFNDVLVVTKKKSE 543
+ R L + ++ E L K+ T Y L D+LV+ +K+ +
Sbjct: 1006 NVEELR-NLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDD 1055
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 76.3 bits (186), Expect = 9e-14
Identities = 109/535 (20%), Positives = 211/535 (39%), Gaps = 78/535 (14%)
Query: 180 LAEEPSQPHTRSPAKNKKTLGRKRGHK--------------GSFKDDPQL------YQEI 219
+ E PS S + + LG +RG G F D+ L Q
Sbjct: 116 IRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQST 175
Query: 220 QERGLNTSQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLS 279
+ S + ++DE+ D + K + A +WS V+ L Q
Sbjct: 176 DSLNMRNRTLSVESLIDEAEVIYSELMSDFEMDEKDF--AADSWSL---AVDSSFLQQHK 230
Query: 280 TEERKRQEAMFEILTSEFSYQHSLSILVEEF----LQSKELRATVTQMEHHHLFSNILDV 335
E K+Q+ ++E++ +E + +L I+ F L+ L V Q LF + ++
Sbjct: 231 KEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQ----GLFPCVDEL 286
Query: 336 LGASQRFFEDLEQRHKAQV--------LVEDISDILEEH-----AEKHFHPYIAYCSNEV 382
RF L +R + + ++ + D+L AE+ Y +CS
Sbjct: 287 SDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHS 346
Query: 383 YQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQ 442
+ ++L + + F++ +R++ R + ++L QR+T+ PLL+ + +
Sbjct: 347 KALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSH 406
Query: 443 GHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLIS----- 497
G E + + AL + +L+ +EG +++E+ ++ ++ ++D +P
Sbjct: 407 GIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGRE 466
Query: 498 --ASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMN 555
R L+ G L TG F+ + + L DVLV ++K ++ Y+ + +
Sbjct: 467 ELLRRKLIHDGCLLWKTATGRFKDV------LVLLMTDVLVFLQEK-DQKYIFPTLDKPS 519
Query: 556 HIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVAL 615
+ ++ + ++ G S P E + + S DR+ WI +
Sbjct: 520 VVSLQNLIVRDIANQEKGMFLISAAPP-------------EMYEVHTASRDDRSTWIRVI 566
Query: 616 THSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLV-LQQEDGWLYGE 669
S R S+ D P +E + ++ ++ LQQ D LV L +E L+ E
Sbjct: 567 QQSVRT---CPSREDFPLIETEDEAYLRRI-KMELQQKDRALVELLREKVGLFAE 617
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 75.1 bits (183), Expect = 2e-13
Identities = 62/276 (22%), Positives = 132/276 (47%), Gaps = 10/276 (3%)
Query: 278 LSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLG 337
L+ E RQE + E+ +E S+ +L +L F Q + + + E LF N+ +++
Sbjct: 768 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 827
Query: 338 ASQRFFEDLEQRHKAQVLVEDISDIL----EEHAEKHFHPYIA-YCSNEVYQQRTLQKLI 392
+ E +++ + ++++ISD++ + A + A +CS + ++
Sbjct: 828 IHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQ 887
Query: 393 SSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAAS 452
+ F+ ++E E P C L + +I MQR+T+ PLL++++ T+G + ++
Sbjct: 888 RKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLC 947
Query: 453 RALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVK--SLPLISASRWLLKRGELFL 510
RA ++++ NE + E ++ +LD + ++ S PL +A L +
Sbjct: 948 RARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPL-AAEFKSLDLTTRKM 1006
Query: 511 VEETGLFRKIASRPT--CYLFLFNDVLVVTKKKSEE 544
+ E L +I+ T ++ L D+LV+ +K+ E+
Sbjct: 1007 IHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEK 1042
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 75.1 bits (183), Expect = 2e-13
Identities = 62/276 (22%), Positives = 132/276 (47%), Gaps = 10/276 (3%)
Query: 278 LSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLG 337
L+ E RQE + E+ +E S+ +L +L F Q + + + E LF N+ +++
Sbjct: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 787
Query: 338 ASQRFFEDLEQRHKAQVLVEDISDIL----EEHAEKHFHPYIA-YCSNEVYQQRTLQKLI 392
+ E +++ + ++++ISD++ + A + A +CS + ++
Sbjct: 788 IHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQ 847
Query: 393 SSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAAS 452
+ F+ ++E E P C L + +I MQR+T+ PLL++++ T+G + ++
Sbjct: 848 RKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLC 907
Query: 453 RALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVK--SLPLISASRWLLKRGELFL 510
RA ++++ NE + E ++ +LD + ++ S PL +A L +
Sbjct: 908 RARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPL-AAEFKSLDLTTRKM 966
Query: 511 VEETGLFRKIASRPT--CYLFLFNDVLVVTKKKSEE 544
+ E L +I+ T ++ L D+LV+ +K+ E+
Sbjct: 967 IHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEK 1002
>gi|222080070 pleckstrin homology domain-containing family G member
6 isoform b [Homo sapiens]
Length = 758
Score = 74.3 bits (181), Expect = 4e-13
Identities = 83/385 (21%), Positives = 158/385 (41%), Gaps = 54/385 (14%)
Query: 277 QLSTEERKRQEAMFEILTSEFSYQHSLSILVEEF---LQSKELRATVTQMEHHHLFSNIL 333
++S E +QEA++E+LT+E Y L I+ + L + + + ++ LF N+
Sbjct: 122 EMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVP 181
Query: 334 DVLGASQRFFEDL------EQRHKAQVL--VEDISDILEEHAEKHFHPYIAYCSNEVYQQ 385
++ + F++++ E R Q L + S L + FHPY+ YC
Sbjct: 182 SLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLT--FGQRFHPYVQYCLRVKQTM 239
Query: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
++ +N F ++ E+ G + LI P QR+T+ PLL+ + LK +
Sbjct: 240 AYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAV-LKRSPEA 298
Query: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKR 505
+A + ++A+ +R N + E E + ++ +V P + L
Sbjct: 299 RAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPF 358
Query: 506 GELFLVEETGLFRKIASRPT--------------------CYLFLFNDVLVVTK--KKSE 543
L L T +AS T YLFLF+DVL+VTK +K++
Sbjct: 359 STLDL---TSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD 415
Query: 544 ESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSD 603
++ +++ + + + + P+ F + L + LL+
Sbjct: 416 KAKVIRPPLMLEKLVCQPLRD---------------PNSFLLIHLTEFQCVSSALLVHCP 460
Query: 604 SASDRARWIVALTHSERQWQGLSSK 628
S +DRA+W+ ++ Q L ++
Sbjct: 461 SPTDRAQWLEKTQQAQAALQKLKAE 485
>gi|222080068 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 74.3 bits (181), Expect = 4e-13
Identities = 83/385 (21%), Positives = 158/385 (41%), Gaps = 54/385 (14%)
Query: 277 QLSTEERKRQEAMFEILTSEFSYQHSLSILVEEF---LQSKELRATVTQMEHHHLFSNIL 333
++S E +QEA++E+LT+E Y L I+ + L + + + ++ LF N+
Sbjct: 154 EMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVP 213
Query: 334 DVLGASQRFFEDL------EQRHKAQVL--VEDISDILEEHAEKHFHPYIAYCSNEVYQQ 385
++ + F++++ E R Q L + S L + FHPY+ YC
Sbjct: 214 SLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLT--FGQRFHPYVQYCLRVKQTM 271
Query: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
++ +N F ++ E+ G + LI P QR+T+ PLL+ + LK +
Sbjct: 272 AYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAV-LKRSPEA 330
Query: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKR 505
+A + ++A+ +R N + E E + ++ +V P + L
Sbjct: 331 RAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPF 390
Query: 506 GELFLVEETGLFRKIASRPT--------------------CYLFLFNDVLVVTK--KKSE 543
L L T +AS T YLFLF+DVL+VTK +K++
Sbjct: 391 STLDL---TSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD 447
Query: 544 ESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSD 603
++ +++ + + + + P+ F + L + LL+
Sbjct: 448 KAKVIRPPLMLEKLVCQPLRD---------------PNSFLLIHLTEFQCVSSALLVHCP 492
Query: 604 SASDRARWIVALTHSERQWQGLSSK 628
S +DRA+W+ ++ Q L ++
Sbjct: 493 SPTDRAQWLEKTQQAQAALQKLKAE 517
>gi|222080066 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 74.3 bits (181), Expect = 4e-13
Identities = 83/385 (21%), Positives = 158/385 (41%), Gaps = 54/385 (14%)
Query: 277 QLSTEERKRQEAMFEILTSEFSYQHSLSILVEEF---LQSKELRATVTQMEHHHLFSNIL 333
++S E +QEA++E+LT+E Y L I+ + L + + + ++ LF N+
Sbjct: 154 EMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVP 213
Query: 334 DVLGASQRFFEDL------EQRHKAQVL--VEDISDILEEHAEKHFHPYIAYCSNEVYQQ 385
++ + F++++ E R Q L + S L + FHPY+ YC
Sbjct: 214 SLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLT--FGQRFHPYVQYCLRVKQTM 271
Query: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
++ +N F ++ E+ G + LI P QR+T+ PLL+ + LK +
Sbjct: 272 AYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAV-LKRSPEA 330
Query: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKR 505
+A + ++A+ +R N + E E + ++ +V P + L
Sbjct: 331 RAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPF 390
Query: 506 GELFLVEETGLFRKIASRPT--------------------CYLFLFNDVLVVTK--KKSE 543
L L T +AS T YLFLF+DVL+VTK +K++
Sbjct: 391 STLDL---TSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD 447
Query: 544 ESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSD 603
++ +++ + + + + P+ F + L + LL+
Sbjct: 448 KAKVIRPPLMLEKLVCQPLRD---------------PNSFLLIHLTEFQCVSSALLVHCP 492
Query: 604 SASDRARWIVALTHSERQWQGLSSK 628
S +DRA+W+ ++ Q L ++
Sbjct: 493 SPTDRAQWLEKTQQAQAALQKLKAE 517
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 73.9 bits (180), Expect = 5e-13
Identities = 82/364 (22%), Positives = 164/364 (45%), Gaps = 18/364 (4%)
Query: 268 EVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHH 327
E+V L L + KRQE + E+L +E ++ L +L + F Q E +
Sbjct: 415 ELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQN 474
Query: 328 LFSNILDVLGASQRFFEDL-EQRHKAQVLVEDISDILE---EHAEKHFHPYIA--YCSNE 381
+F ++ +++ F + L ++R ++ L+E+I D+L + AE + I+ +CS +
Sbjct: 475 IFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQ 534
Query: 382 VYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKT 441
+ L+ + F ++E E RP C L + + MQR+T+ PLL+ ++ T
Sbjct: 535 SFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT 594
Query: 442 QGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVK--SLPLISAS 499
+ +ER K A + +++ N+ ME + ++ +LD S ++ S P++S
Sbjct: 595 EEPTEREK-VELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEF 653
Query: 500 RWLLKRGELFLVEETGLFRKIASRPT--CYLFLFNDVLVVTKKKSEESYMVQDYAQMNHI 557
+ L + LV E L ++ ++ L +D+L++ +++ E + +
Sbjct: 654 K-NLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPT 712
Query: 558 QVEK--IEPSELPLPGGGNRSSSVPH-PFQVTLLRNSEGRQEQLLLSSDSASDRARWIVA 614
K + P L L R + H F V + E + +L+ + + S+R W
Sbjct: 713 PDGKTMLRP-VLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELV--AQTVSERKNWCAL 769
Query: 615 LTHS 618
+T +
Sbjct: 770 ITET 773
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 73.9 bits (180), Expect = 5e-13
Identities = 82/364 (22%), Positives = 164/364 (45%), Gaps = 18/364 (4%)
Query: 268 EVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHH 327
E+V L L + KRQE + E+L +E ++ L +L + F Q E +
Sbjct: 367 ELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQN 426
Query: 328 LFSNILDVLGASQRFFEDL-EQRHKAQVLVEDISDILE---EHAEKHFHPYIA--YCSNE 381
+F ++ +++ F + L ++R ++ L+E+I D+L + AE + I+ +CS +
Sbjct: 427 IFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQ 486
Query: 382 VYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKT 441
+ L+ + F ++E E RP C L + + MQR+T+ PLL+ ++ T
Sbjct: 487 SFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT 546
Query: 442 QGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVK--SLPLISAS 499
+ +ER K A + +++ N+ ME + ++ +LD S ++ S P++S
Sbjct: 547 EEPTEREK-VELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEF 605
Query: 500 RWLLKRGELFLVEETGLFRKIASRPT--CYLFLFNDVLVVTKKKSEESYMVQDYAQMNHI 557
+ L + LV E L ++ ++ L +D+L++ +++ E + +
Sbjct: 606 K-NLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPT 664
Query: 558 QVEK--IEPSELPLPGGGNRSSSVPH-PFQVTLLRNSEGRQEQLLLSSDSASDRARWIVA 614
K + P L L R + H F V + E + +L+ + + S+R W
Sbjct: 665 PDGKTMLRP-VLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELV--AQTVSERKNWCAL 721
Query: 615 LTHS 618
+T +
Sbjct: 722 ITET 725
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 73.9 bits (180), Expect = 5e-13
Identities = 82/364 (22%), Positives = 164/364 (45%), Gaps = 18/364 (4%)
Query: 268 EVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHH 327
E+V L L + KRQE + E+L +E ++ L +L + F Q E +
Sbjct: 400 ELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQN 459
Query: 328 LFSNILDVLGASQRFFEDL-EQRHKAQVLVEDISDILE---EHAEKHFHPYIA--YCSNE 381
+F ++ +++ F + L ++R ++ L+E+I D+L + AE + I+ +CS +
Sbjct: 460 IFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQ 519
Query: 382 VYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKT 441
+ L+ + F ++E E RP C L + + MQR+T+ PLL+ ++ T
Sbjct: 520 SFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT 579
Query: 442 QGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVK--SLPLISAS 499
+ +ER K A + +++ N+ ME + ++ +LD S ++ S P++S
Sbjct: 580 EEPTEREK-VELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEF 638
Query: 500 RWLLKRGELFLVEETGLFRKIASRPT--CYLFLFNDVLVVTKKKSEESYMVQDYAQMNHI 557
+ L + LV E L ++ ++ L +D+L++ +++ E + +
Sbjct: 639 K-NLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPT 697
Query: 558 QVEK--IEPSELPLPGGGNRSSSVPH-PFQVTLLRNSEGRQEQLLLSSDSASDRARWIVA 614
K + P L L R + H F V + E + +L+ + + S+R W
Sbjct: 698 PDGKTMLRP-VLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELV--AQTVSERKNWCAL 754
Query: 615 LTHS 618
+T +
Sbjct: 755 ITET 758
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 73.6 bits (179), Expect = 6e-13
Identities = 83/368 (22%), Positives = 156/368 (42%), Gaps = 43/368 (11%)
Query: 283 RKRQEAMFEILTSEFSYQHSLSILVEEFLQ------SKELRATVTQMEHHHLFSNILDVL 336
R R + EIL +E Y +L L FL + + +T+ LFSNI D+L
Sbjct: 48 RLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDIL 107
Query: 337 GASQRFFEDLEQ-RHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKL--IS 393
+ F LE H ++ ++ + +K F Y YCSN R L +L I
Sbjct: 108 EVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDK-FCVYEEYCSNHEKALRLLVELNKIP 166
Query: 394 SNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASR 453
+ AF + + R +P+ +L+ P+QR+ + PLL+ L +T G + A
Sbjct: 167 TVRAFLLSCMLLGGRKTTD-IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQS 225
Query: 454 ALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEE 513
AL+A+ + NE +ME++E + L + ++ + +L I LL +G L +
Sbjct: 226 ALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQ--LLLQGTLLKISA 283
Query: 514 TGLFRKIASRPTCYLFLFNDVLVVTKKKSEES----------------YMVQDYAQMNHI 557
+ + FLF+++LV K+KS + Y+ + +
Sbjct: 284 GNIQERA-------FFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVM 336
Query: 558 QVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALTH 617
+VE +E G +V + +++ ++ + + + + +A ++ +W+ A+
Sbjct: 337 EVENVEDGTADYHSNG---YTVTNGWKI----HNTAKNKWFVCMAKTAEEKQKWLDAIIR 389
Query: 618 SERQWQGL 625
Q + L
Sbjct: 390 EREQRESL 397
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 73.2 bits (178), Expect = 8e-13
Identities = 88/425 (20%), Positives = 177/425 (41%), Gaps = 53/425 (12%)
Query: 270 VELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEF----LQSKELRATVTQMEH 325
V+ L Q E K+Q+ ++E++ +E + +L I+ F L+ L V Q
Sbjct: 220 VDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQ--- 276
Query: 326 HHLFSNILDVLGASQRFFEDLEQRHKAQV--------LVEDISDILEEH-----AEKHFH 372
LF + ++ RF L +R + + ++ + D+L AE+
Sbjct: 277 -GLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
Query: 373 PYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPL 432
Y +CS + ++L + + F++ +R++ R + ++L QR+T+ PL
Sbjct: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395
Query: 433 LMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKS 492
L+ + + G E + + AL + +L+ +EG +++E+ ++ ++ ++D
Sbjct: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTP 455
Query: 493 LPLIS-------ASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEES 545
+P R L+ G L TG F+ + + L DVLV ++K ++
Sbjct: 456 VPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDV------LVLLMTDVLVFLQEK-DQK 508
Query: 546 YMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSA 605
Y+ + + + ++ + ++ G S P E + + S
Sbjct: 509 YIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPP-------------EMYEVHTASR 555
Query: 606 SDRARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLV-LQQEDG 664
DR+ WI + S R S+ D P +E + ++ ++ LQQ D LV L +E
Sbjct: 556 DDRSTWIRVIQQSVRT---CPSREDFPLIETEDEAYLRRI-KMELQQKDRALVELLREKV 611
Query: 665 WLYGE 669
L+ E
Sbjct: 612 GLFAE 616
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,870,878
Number of Sequences: 37866
Number of extensions: 1408022
Number of successful extensions: 8322
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 198
Number of HSP's that attempted gapping in prelim test: 7778
Number of HSP's gapped (non-prelim): 589
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.