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Search of human proteins with 157738619
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157738619 smoothelin-like 1 [Homo sapiens]
(512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157738619 smoothelin-like 1 [Homo sapiens] 1020 0.0
gi|19913396 smoothelin isoform b [Homo sapiens] 204 1e-52
gi|19913394 smoothelin isoform c [Homo sapiens] 173 4e-43
gi|19913398 smoothelin isoform a [Homo sapiens] 169 6e-42
gi|169234649 smoothelin-like 2 isoform 2 [Homo sapiens] 164 2e-40
gi|169234647 smoothelin-like 2 isoform 1 [Homo sapiens] 164 2e-40
gi|150378549 tangerin [Homo sapiens] 108 9e-24
gi|224451082 cytospin A [Homo sapiens] 107 3e-23
gi|224451080 cytospin A [Homo sapiens] 107 3e-23
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 97 3e-20
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa... 97 5e-20
gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo sa... 97 5e-20
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 94 3e-19
gi|217330568 EH domain binding protein 1 isoform 1 [Homo sapiens] 93 5e-19
gi|4557241 actinin, alpha 3 [Homo sapiens] 93 7e-19
gi|217330574 EH domain binding protein 1 isoform 3 [Homo sapiens] 93 7e-19
gi|217330572 EH domain binding protein 1 isoform 3 [Homo sapiens] 93 7e-19
gi|217330570 EH domain binding protein 1 isoform 2 [Homo sapiens] 93 7e-19
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 93 7e-19
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 93 7e-19
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 93 7e-19
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 92 9e-19
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 92 9e-19
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 91 3e-18
gi|4501893 actinin, alpha 2 [Homo sapiens] 89 1e-17
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 88 2e-17
gi|67782321 spectrin beta isoform a [Homo sapiens] 87 3e-17
gi|67782319 spectrin beta isoform b [Homo sapiens] 87 3e-17
gi|12025678 actinin, alpha 4 [Homo sapiens] 87 5e-17
gi|31324577 molecule interacting with Rab13 [Homo sapiens] 86 6e-17
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 1020 bits (2637), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MLPGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAI 60
MLPGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAI
Sbjct: 1 MLPGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAI 60
Query: 61 NEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKE 120
NEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKE
Sbjct: 61 NEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKE 120
Query: 121 ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180
ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP
Sbjct: 121 ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180
Query: 181 KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE 240
KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE
Sbjct: 181 KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE 240
Query: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGE 300
EAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGE
Sbjct: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGE 300
Query: 301 GHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPR 360
GHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPR
Sbjct: 301 GHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPR 360
Query: 361 GPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQN 420
GPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQN
Sbjct: 361 GPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQN 420
Query: 421 FSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMV 480
FSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMV
Sbjct: 421 FSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMV 480
Query: 481 RLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK 512
RLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK
Sbjct: 481 RLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK 512
>gi|19913396 smoothelin isoform b [Homo sapiens]
Length = 915
Score = 204 bits (520), Expect = 1e-52
Identities = 133/388 (34%), Positives = 196/388 (50%), Gaps = 40/388 (10%)
Query: 149 TLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDAKTASQEETGQRKECSTEP 207
++ E + AE A E+ A+ +K PE ++ + E+ T E
Sbjct: 542 SIKMEAEPAEPLAAAVEAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGV---------- 591
Query: 208 KEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSP 267
+K D+ E +K + + ++ D +++ + +EA + E +
Sbjct: 592 LDKMLDQSTDFEERKLIRAALRELRQRKRDQRDKERERRLQEARGRPG-----EGRGNTA 646
Query: 268 SEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLST-----------DGLGPDCVAS 316
+E + ++ +G A + E S G +T +G G + +
Sbjct: 647 TETTTRHSQRAADGSAVSTVTKTERLVHSNDGTRTARTTTVESSFVRRSENGSGSTMMQT 706
Query: 317 GQTSPSASESSPSDV----PQSPPESPSSGEKKEKAPERR---VSAPARPRGPRAQNRKA 369
S S+S + Q+ P + S +++ E++ + A + P+ +Q RKA
Sbjct: 707 KTFSSSSSSKKMGSIFDREDQASPRAGSLAALEKRQAEKKKELMKAQSLPKTSASQARKA 766
Query: 370 IVDKF-----GGAASGPTALFRNTKAAGAA-IGGVKNMLLEWCRAMTKKYEHVDIQNFSS 423
+++K G+ GP A + + + G +K MLL+WCRA T+ YEHVDIQNFSS
Sbjct: 767 MIEKLEKEGAAGSPGGPRAAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSS 826
Query: 424 SWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLA 483
SWS GMAFCAL+H FFP+AFDY +L P RR NF +AFS+AE ADC QLLD +DMVRL
Sbjct: 827 SWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEVAFSSAETHADCPQLLDTEDMVRLR 886
Query: 484 VPDSKCVYTYIQELYRSLVQKGLVKTKK 511
PD KCVYTYIQE YR LVQKGLVKTKK
Sbjct: 887 EPDWKCVYTYIQEFYRCLVQKGLVKTKK 914
Score = 39.7 bits (91), Expect = 0.007
Identities = 69/301 (22%), Positives = 108/301 (35%), Gaps = 62/301 (20%)
Query: 111 ELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE-SGQK 169
EL++++ E+EE + S+ +++ K E+ L S++++AE++ A +GQ
Sbjct: 36 ELQRQELEREEEALASKRFRAERQDNK---------ENWLHSQQREAEQRAALARLAGQL 86
Query: 170 ADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA 229
ND VEE A S E +RK +A +A+ +A
Sbjct: 87 ESMND---------VEELTALLRSAGEYEERKLI------RAAIRRVRAQEIEAATLAGR 131
Query: 230 KAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSS 289
+ G E G A E E E EEQEQ E S
Sbjct: 132 LYSGRPNSGSREDSKGL-----AAHRLEQCEVPE----REEQEQQAEV----------SK 172
Query: 290 PEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGE------ 343
P PE + + ++ P S +SP++ SSP+ PP P+ +
Sbjct: 173 PTPTPEGTSQDVTTVTLLLRAPP--GSTSSSPASPSSSPTPASPEPPLEPAEAQCLTAEV 230
Query: 344 ----------KKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGA 393
K +PE + S + N+ K AA PT +TK A
Sbjct: 231 PGSPEPPPSPPKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPTRGPSDTKRADV 290
Query: 394 A 394
A
Sbjct: 291 A 291
>gi|19913394 smoothelin isoform c [Homo sapiens]
Length = 917
Score = 173 bits (438), Expect = 4e-43
Identities = 116/379 (30%), Positives = 184/379 (48%), Gaps = 41/379 (10%)
Query: 149 TLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDAKTASQEETGQRKECSTEP 207
++ E + AE A E+ A+ +K PE ++ + E+ T E
Sbjct: 542 SIKMEAEPAEPLAAAVEAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGV---------- 591
Query: 208 KEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSP 267
+K D+ E +K + + ++ D +++ + +EA + E +
Sbjct: 592 LDKMLDQSTDFEERKLIRAALRELRQRKRDQRDKERERRLQEARGRPG-----EGRGNTA 646
Query: 268 SEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLST-----------DGLGPDCVAS 316
+E + ++ +G A + E S G +T +G G + +
Sbjct: 647 TETTTRHSQRAADGSAVSTVTKTERLVHSNDGTRTARTTTVESSFVRRSENGSGSTMMQT 706
Query: 317 GQTSPSASESSPSDV----PQSPPESPSSGEKKEKAPERR---VSAPARPRGPRAQNRKA 369
S S+S + Q+ P + S +++ E++ + A + P+ +Q RKA
Sbjct: 707 KTFSSSSSSKKMGSIFDREDQASPRAGSLAALEKRQAEKKKELMKAQSLPKTSASQARKA 766
Query: 370 IVDKF-----GGAASGPTALFRNTKAAGAA-IGGVKNMLLEWCRAMTKKYEHVDIQNFSS 423
+++K G+ GP A + + + G +K MLL+WCRA T+ YEHVDIQNFSS
Sbjct: 767 MIEKLEKEGAAGSPGGPRAAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSS 826
Query: 424 SWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLA 483
SWS GMAFCAL+H FFP+AFDY +L P RR NF +AFS+AE L DC L++VDDM+ +
Sbjct: 827 SWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEVAFSSAEMLVDCVPLVEVDDMMIMG 886
Query: 484 -VPDSKCVYTYIQELYRSL 501
PD KCV+TY+Q LY L
Sbjct: 887 KKPDPKCVFTYVQSLYNHL 905
Score = 39.7 bits (91), Expect = 0.007
Identities = 69/301 (22%), Positives = 108/301 (35%), Gaps = 62/301 (20%)
Query: 111 ELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE-SGQK 169
EL++++ E+EE + S+ +++ K E+ L S++++AE++ A +GQ
Sbjct: 36 ELQRQELEREEEALASKRFRAERQDNK---------ENWLHSQQREAEQRAALARLAGQL 86
Query: 170 ADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA 229
ND VEE A S E +RK +A +A+ +A
Sbjct: 87 ESMND---------VEELTALLRSAGEYEERKLI------RAAIRRVRAQEIEAATLAGR 131
Query: 230 KAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSS 289
+ G E G A E E E EEQEQ E S
Sbjct: 132 LYSGRPNSGSREDSKGL-----AAHRLEQCEVPE----REEQEQQAEV----------SK 172
Query: 290 PEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGE------ 343
P PE + + ++ P S +SP++ SSP+ PP P+ +
Sbjct: 173 PTPTPEGTSQDVTTVTLLLRAPP--GSTSSSPASPSSSPTPASPEPPLEPAEAQCLTAEV 230
Query: 344 ----------KKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGA 393
K +PE + S + N+ K AA PT +TK A
Sbjct: 231 PGSPEPPPSPPKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPTRGPSDTKRADV 290
Query: 394 A 394
A
Sbjct: 291 A 291
>gi|19913398 smoothelin isoform a [Homo sapiens]
Length = 940
Score = 169 bits (428), Expect = 6e-42
Identities = 120/402 (29%), Positives = 185/402 (46%), Gaps = 64/402 (15%)
Query: 149 TLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDAKTASQEETGQRKECSTEP 207
++ E + AE A E+ A+ +K PE ++ + E+ T E
Sbjct: 542 SIKMEAEPAEPLAAAVEAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGV---------- 591
Query: 208 KEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSP 267
+K D+ E +K + + ++ D +++ + +EA + E +
Sbjct: 592 LDKMLDQSTDFEERKLIRAALRELRQRKRDQRDKERERRLQEARGRPG-----EGRGNTA 646
Query: 268 SEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLST-----------DGLGPDCVAS 316
+E + ++ +G A + E S G +T +G G + +
Sbjct: 647 TETTTRHSQRAADGSAVSTVTKTERLVHSNDGTRTARTTTVESSFVRRSENGSGSTMMQT 706
Query: 317 GQTSPSASESSPSDV----PQSPPESPSSGEKKEKAPERR---VSAPARPRGPRAQNRKA 369
S S+S + Q+ P + S +++ E++ + A + P+ +Q RKA
Sbjct: 707 KTFSSSSSSKKMGSIFDREDQASPRAGSLAALEKRQAEKKKELMKAQSLPKTSASQARKA 766
Query: 370 IVDKF-----GGAASGPTALFRNTKAAGAA-IGGVKNMLLEWCRAMTKKYEHVDIQNFSS 423
+++K G+ GP A + + + G +K MLL+WCRA T+ YEHVDIQNFSS
Sbjct: 767 MIEKLEKEGAAGSPGGPRAAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSS 826
Query: 424 SWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRL- 482
SWS GMAFCAL+H FFP+AFDY +L P RR NF +AFS+AE ADC QLLD +DMVRL
Sbjct: 827 SWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEVAFSSAETHADCPQLLDTEDMVRLR 886
Query: 483 -----------------------AVPDSKCVYTYIQELYRSL 501
PD KCV+TY+Q LY L
Sbjct: 887 EPDWKMLVDCVPLVEVDDMMIMGKKPDPKCVFTYVQSLYNHL 928
Score = 52.0 bits (123), Expect = 1e-06
Identities = 62/267 (23%), Positives = 104/267 (38%), Gaps = 32/267 (11%)
Query: 111 ELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE-SGQK 169
EL++++ E+EE + S+ +++ K E+ L S++++AE++ A +GQ
Sbjct: 36 ELQRQELEREEEALASKRFRAERQDNK---------ENWLHSQQREAEQRAALARLAGQL 86
Query: 170 ADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA 229
ND VEE A S E +RK + E A +
Sbjct: 87 ESMND---------VEELTALLRSAGEYEERKLIRAAIRRVRAQEIEAATLAGRLYSGRP 137
Query: 230 KAEPKEPDGKEEAKHGAK--EEADAKEEAEDAEEAEPGSPSEEQEQDVE------KEPEG 281
+ +E D K A H + E + +E+ + AE ++P E QDV + P G
Sbjct: 138 NSGSRE-DSKGLAAHRLEQCEVPEREEQEQQAEVSKPTPTPEGTSQDVTTVTLLLRAPPG 196
Query: 282 GAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCV-ASGQTSPSASESSPSDVPQSPPESPS 340
P+SP SPT + C+ A SP S P P ESP+
Sbjct: 197 STSSSPASPSS---SPTPASPEPPLEPAEAQCLTAEVPGSPEPPPSPPKTTSPEPQESPT 253
Query: 341 SGEKKEKAPERRVSAPARPRGPRAQNR 367
+ + + +S P ++ +R
Sbjct: 254 LPSTEGQVVNKLLSGPKETPAAQSPHR 280
>gi|169234649 smoothelin-like 2 isoform 2 [Homo sapiens]
Length = 317
Score = 164 bits (414), Expect = 2e-40
Identities = 97/237 (40%), Positives = 135/237 (56%), Gaps = 24/237 (10%)
Query: 284 GVIPSSPE---EWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPS 340
G+ PS E W SP+ + + + +SG + +AS+ S S +PP+SP
Sbjct: 82 GLNPSPSEVITPWTPSPSEKNSSFTWS-----VPSSGYGAVTASKHSNSPPLVTPPQSPV 136
Query: 341 SGE-----KKEKAPERR---VSAPARPRGPRAQNRKAIVDKFG-------GAASGPTALF 385
S + + + ERR V + PR AQ RKA+ +K+ G L
Sbjct: 137 SPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGEARARLK 196
Query: 386 RNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDY 445
R+ A+ +K +LLEWCR+ T Y+HVD+QNFSSSWS GMAFCAL+H FFPDAFDY
Sbjct: 197 RSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDY 256
Query: 446 AELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLA-VPDSKCVYTYIQELYRSL 501
L P +R+ NF LAF+ AE LA+C +L++V+DM+ + PD CV+TY+Q LY L
Sbjct: 257 NSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHL 313
>gi|169234647 smoothelin-like 2 isoform 1 [Homo sapiens]
Length = 461
Score = 164 bits (414), Expect = 2e-40
Identities = 97/237 (40%), Positives = 135/237 (56%), Gaps = 24/237 (10%)
Query: 284 GVIPSSPE---EWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPS 340
G+ PS E W SP+ + + + +SG + +AS+ S S +PP+SP
Sbjct: 226 GLNPSPSEVITPWTPSPSEKNSSFTWS-----VPSSGYGAVTASKHSNSPPLVTPPQSPV 280
Query: 341 SGE-----KKEKAPERR---VSAPARPRGPRAQNRKAIVDKFG-------GAASGPTALF 385
S + + + ERR V + PR AQ RKA+ +K+ G L
Sbjct: 281 SPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGEARARLK 340
Query: 386 RNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDY 445
R+ A+ +K +LLEWCR+ T Y+HVD+QNFSSSWS GMAFCAL+H FFPDAFDY
Sbjct: 341 RSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDY 400
Query: 446 AELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLA-VPDSKCVYTYIQELYRSL 501
L P +R+ NF LAF+ AE LA+C +L++V+DM+ + PD CV+TY+Q LY L
Sbjct: 401 NSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHL 457
>gi|150378549 tangerin [Homo sapiens]
Length = 1523
Score = 108 bits (271), Expect = 9e-24
Identities = 125/440 (28%), Positives = 183/440 (41%), Gaps = 88/440 (20%)
Query: 69 GKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQE 128
G QE A + G+ L+ + G+ +E GG E E G E +G+QE
Sbjct: 775 GTQEIASRDSGVPG-LEADTTGIQV------KEVGGSEVPEIAT----GTAETEILGTQE 823
Query: 129 MTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATV---E 185
+ R S E E A E + + PE+G A+A + + V E
Sbjct: 824 IASR-----SSGVPGLESEVAGAQETEVGGSGISGPEAGM-AEARVLMTRKTEIIVPEAE 877
Query: 186 EEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKE----- 240
+E+A+T+ +E R + K A + + EAKAE G E
Sbjct: 878 KEEAQTSGVQEAETRVGSAL----KYEALRAPVTQPRVLGSQEAKAEISGVQGSETQVLR 933
Query: 241 --EAKHGAKEEADAKEEAEDAEEAEPGS-PSEEQEQDVEKEPEGGAGVIPSSPEEWPESP 297
EA+ G ++ K A A+EAE S E + K E AGV+ + + E
Sbjct: 934 VQEAEAGVWGMSEGKSGAWGAQEAEMKVLESPENKSGTFKAQEAEAGVLGNEKGKEAEG- 992
Query: 298 TGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPA 357
+L+ L VASG + + SSP EKA E R
Sbjct: 993 -----SLTEASLPEAQVASGAGAGAPRASSP-----------------EKAEEDR----- 1025
Query: 358 RPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVD 417
R P +Q P AL ++++ LLEWC+ +T Y V
Sbjct: 1026 --RLPGSQ--------------APPALVSSSQS-----------LLEWCQEVTTGYRGVR 1058
Query: 418 IQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVD 477
I NF++SW +G+AFCA++H+F+PD DYA LDP + N AF L ++LL+
Sbjct: 1059 ITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQAFDGFAALG-VSRLLEPA 1117
Query: 478 DMVRLAVPDSKCVYTYIQEL 497
DMV L+VPD V TY+ ++
Sbjct: 1118 DMVLLSVPDKLIVMTYLCQI 1137
Score = 47.4 bits (111), Expect = 3e-05
Identities = 70/319 (21%), Positives = 110/319 (34%), Gaps = 39/319 (12%)
Query: 15 AREKMEQKEGKLSEDGTTVSPAAD-----NPEMSGGGAPAEETKGTAGKAINEG-----P 64
AR Q + +E G V P A +PEM PA++T T + +G P
Sbjct: 256 ARTSRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRP 315
Query: 65 PTESGKQE------KAPAEDGMSAELQGEANGLDEVKVESQREAGGKED-------AEAE 111
P G+ E PA G + E Q +A + + R ED
Sbjct: 316 PVPQGEDEVPKASGAPPAGLGSARETQAQACPQEGTEAHGARLGPSIEDKGSGDPFGRQR 375
Query: 112 LKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKAD 171
LK E+ + E+ E +G E +S +EA K S + + + + + ++ Q++
Sbjct: 376 LKAEEMDTEDRP----EASGVDTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSK 431
Query: 172 ANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKA 231
D P+AT +A+ E R + DE S A
Sbjct: 432 VRHVDTKGPEATGVMPEARCRGTPEAPPRGS-QGRLGVRTRDEAPSGLSL-------PPA 483
Query: 232 EPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPE 291
EP G+ GA+ A + E + PG + +E+ P GA
Sbjct: 484 EPAGHSGQLGDLEGARAAAGQEREGAEVRGGAPGI----EGTGLEQGPSVGAISTRPQVS 539
Query: 292 EWPESPTGEGHNLSTDGLG 310
W + + GLG
Sbjct: 540 SWQGALLSTAQGAISRGLG 558
Score = 34.3 bits (77), Expect = 0.28
Identities = 40/163 (24%), Positives = 58/163 (35%), Gaps = 22/163 (13%)
Query: 228 EAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIP 287
EA+A +PD E K +EE EE + + SPS +D P P
Sbjct: 203 EARARVPQPDPSRELKTLCEEE----EEGQGRPQQAVASPS--NAEDTSPAPVSA----P 252
Query: 288 SSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEK 347
+ P E N + +GP+ +TSP S +P +P
Sbjct: 253 APPARTSRGQGSERANEAGGQVGPEAPRPPETSPEMRSSRQPAQDTAPTPAPRL------ 306
Query: 348 APERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKA 390
R+ S RP P+ ++ V K GA R T+A
Sbjct: 307 ---RKGSDALRPPVPQGEDE---VPKASGAPPAGLGSARETQA 343
>gi|224451082 cytospin A [Homo sapiens]
Length = 1117
Score = 107 bits (266), Expect = 3e-23
Identities = 109/444 (24%), Positives = 174/444 (39%), Gaps = 68/444 (15%)
Query: 82 AELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPK 141
++L+ L + K + +RE + L++E E + Q + KSE +
Sbjct: 712 SDLENTVKKLQDQKHDMEREI---KTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQ 768
Query: 142 E-----------AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAK 190
E A+EK L E ++ + ++ + E G+ + + VE + A
Sbjct: 769 EEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMN--------AVERDLAA 820
Query: 191 TASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEA 250
+R S+EP +S V A A P+ P K A
Sbjct: 821 LRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMK---TPPA 877
Query: 251 DAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIP---------SSPEEWPESPTGEG 301
A + + P S S+ +K P G + S P P P E
Sbjct: 878 AAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMES 937
Query: 302 HNL------STDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSA 355
S++ + D A SP++ + + PQ S SS P R
Sbjct: 938 AKTLSVSRRSSEEVKRDISAQEGASPASLMAMGTTSPQL---SLSSSPTASVTPTTR--- 991
Query: 356 PARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEH 415
+R R R A+ ++GG+ +N LL+WC+ T+ Y++
Sbjct: 992 -SRIREERKDPLSALAREYGGSK--------------------RNALLKWCQKKTEGYQN 1030
Query: 416 VDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLD 475
+DI NFSSSW+ G+AFCAL+H + P Y EL+ +R NF LAF AE + LD
Sbjct: 1031 IDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFMLAFQAAESVG-IKSTLD 1089
Query: 476 VDDMVRLAVPDSKCVYTYIQELYR 499
+++MVR PD + V Y+ +Y+
Sbjct: 1090 INEMVRTERPDWQNVMLYVTAIYK 1113
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/193 (22%), Positives = 77/193 (39%), Gaps = 18/193 (9%)
Query: 79 GMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEETTVGSQEMTGRKEETK 137
G+ L ++ E+Q G ++ +++ + E++ + + K
Sbjct: 511 GVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVA 570
Query: 138 SEPKEAEEKESTLASEKQKAEEKEAKPESGQKADAN--------DRDKPEPKATVEEED- 188
S+ E ++ L +EKQK E + SG K+D D++K E A+ +ED
Sbjct: 571 SDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL 630
Query: 189 AKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKE 248
A T + Q E + +A EEAK + +ED K +E + E
Sbjct: 631 AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQ-----IEDLNMTLEKLRSDLDEKE---TE 682
Query: 249 EADAKEEAEDAEE 261
+D KE + E+
Sbjct: 683 RSDMKETIFELED 695
>gi|224451080 cytospin A [Homo sapiens]
Length = 1117
Score = 107 bits (266), Expect = 3e-23
Identities = 109/444 (24%), Positives = 174/444 (39%), Gaps = 68/444 (15%)
Query: 82 AELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPK 141
++L+ L + K + +RE + L++E E + Q + KSE +
Sbjct: 712 SDLENTVKKLQDQKHDMEREI---KTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQ 768
Query: 142 E-----------AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAK 190
E A+EK L E ++ + ++ + E G+ + + VE + A
Sbjct: 769 EEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMN--------AVERDLAA 820
Query: 191 TASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEA 250
+R S+EP +S V A A P+ P K A
Sbjct: 821 LRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMK---TPPA 877
Query: 251 DAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIP---------SSPEEWPESPTGEG 301
A + + P S S+ +K P G + S P P P E
Sbjct: 878 AAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMES 937
Query: 302 HNL------STDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSA 355
S++ + D A SP++ + + PQ S SS P R
Sbjct: 938 AKTLSVSRRSSEEVKRDISAQEGASPASLMAMGTTSPQL---SLSSSPTASVTPTTR--- 991
Query: 356 PARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEH 415
+R R R A+ ++GG+ +N LL+WC+ T+ Y++
Sbjct: 992 -SRIREERKDPLSALAREYGGSK--------------------RNALLKWCQKKTEGYQN 1030
Query: 416 VDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLD 475
+DI NFSSSW+ G+AFCAL+H + P Y EL+ +R NF LAF AE + LD
Sbjct: 1031 IDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFMLAFQAAESVG-IKSTLD 1089
Query: 476 VDDMVRLAVPDSKCVYTYIQELYR 499
+++MVR PD + V Y+ +Y+
Sbjct: 1090 INEMVRTERPDWQNVMLYVTAIYK 1113
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/193 (22%), Positives = 77/193 (39%), Gaps = 18/193 (9%)
Query: 79 GMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEETTVGSQEMTGRKEETK 137
G+ L ++ E+Q G ++ +++ + E++ + + K
Sbjct: 511 GVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVA 570
Query: 138 SEPKEAEEKESTLASEKQKAEEKEAKPESGQKADAN--------DRDKPEPKATVEEED- 188
S+ E ++ L +EKQK E + SG K+D D++K E A+ +ED
Sbjct: 571 SDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL 630
Query: 189 AKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKE 248
A T + Q E + +A EEAK + +ED K +E + E
Sbjct: 631 AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQ-----IEDLNMTLEKLRSDLDEKE---TE 682
Query: 249 EADAKEEAEDAEE 261
+D KE + E+
Sbjct: 683 RSDMKETIFELED 695
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 97.4 bits (241), Expect = 3e-20
Identities = 98/329 (29%), Positives = 151/329 (45%), Gaps = 33/329 (10%)
Query: 7 GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPT 66
GE + RE+ E+KEG+ E+G + E G EE G K EG
Sbjct: 736 GEGEEEEGDREEEEEKEGEGKEEGEGEEVEGER-EKEEGERKKEERAGKEEKGEEEGDQG 794
Query: 67 ESGKQEKAPAEDGMSAELQGEANG--LDEVKVE--SQREAGGKEDAEAELKKEDGE-KEE 121
E G++E+ G E GE G ++E K E + E G E+ E E ++E+GE +EE
Sbjct: 795 E-GEEEETEGR-GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE 852
Query: 122 TTVGSQEMTGRKEETKSEPKE----AEEKESTLASEKQ---KAEEKEAKPESGQKADA-N 173
G E G + E + E +E EE+E E++ + EE+E + E ++ +
Sbjct: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912
Query: 174 DRDKPEPKATVEEEDAKTASQEETGQRK----ECSTEPKE---KATDEEAKAESQKAVVE 226
+ ++ E K E E+ + +EE G+ + E E +E + +EE + E ++ E
Sbjct: 913 EEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE---E 969
Query: 227 DEAKAEPKEPDGKEEAKHGAKEEADAKEEAE---DAEEAEPGSPSEEQEQDVEKEPEGGA 283
E + E E +G+EE G EE + +EE E + EE G EE+E +VE E EG
Sbjct: 970 GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEE 1029
Query: 284 GVIPSSPEEWPESPTGEGHNLSTDGLGPD 312
G EE E EG +G G +
Sbjct: 1030 GEGEGEEEEGEE----EGEEREKEGEGEE 1054
Score = 96.7 bits (239), Expect = 5e-20
Identities = 101/398 (25%), Positives = 155/398 (38%), Gaps = 68/398 (17%)
Query: 12 SAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGA------------PAEETKGTAGKA 59
S + +K E EGK +V A D PE G G E KG K
Sbjct: 627 SDDLTDKAEVSEGKAK----SVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKG 682
Query: 60 INEGPPTESGKQEKAPAE-----DGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKK 114
E G++E A E DG E + G + + + E G +E E E ++
Sbjct: 683 RGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEE 742
Query: 115 EDGEKEETTVGSQEMTGRKEETKSE--PKEAEEKESTLASEKQKAEEK------------ 160
D E+EE G + G EE + E +E E K+ A +++K EE+
Sbjct: 743 GDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETE 802
Query: 161 ---EAKPESGQ------KADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKA 211
E K E G+ + +R++ E + EEE+ + +EE G+ +E E K +
Sbjct: 803 GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE--GEEEEGEGEEEEGEGKGEE 860
Query: 212 TDEEAKAESQKAVVEDEAKAEPKEPDGKEEAK-HGAKEEADAKEEAE---DAEEAEPGSP 267
EE + E + E E + E E +G+EE + G +EE + + E E + EE E
Sbjct: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920
Query: 268 SEE---------QEQDVEKEPEGGAGVIPSSPEEW---------PESPTGEGHNLSTDGL 309
EE +E++ E E E G G EW GEG +G
Sbjct: 921 GEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGE 980
Query: 310 GPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEK 347
G + G+ E + + E GE++E+
Sbjct: 981 GEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEE 1018
Score = 92.4 bits (228), Expect = 9e-19
Identities = 104/392 (26%), Positives = 165/392 (42%), Gaps = 56/392 (14%)
Query: 5 AVGESDCSAEAREKMEQKEGK-----------LSEDGTTVSPAADN----PEMSGGGAPA 49
A+ E+D S E E E KEGK +++ TT+ +D PE G A
Sbjct: 537 ALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEG---A 593
Query: 50 EETKGTA-----GKAINEGPPTESGKQEK-----------APAEDGMSAELQGEANGLDE 93
E++KG +A E G++EK A +G A+ GEA E
Sbjct: 594 EDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEG-KAKSVGEAEDGPE 652
Query: 94 VKVESQREAGGK-----EDAEAELKKED---GEKEETTVGSQEMTGRKEETKSEPKEAEE 145
+ + E G +D E E ++D GE E G +E+ ++E K + +E E+
Sbjct: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQ 712
Query: 146 KESTLASEKQKAEEKE--AKPESGQ-KADANDRDKPEPKATVEEEDAKTASQEETGQR-K 201
KE +K++ +E E + E G+ + + DR++ E K +E+ + +E G+R K
Sbjct: 713 KEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE--GEEVEGEREK 770
Query: 202 ECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGK-EEAKHGAKEEADAKEE--AED 258
E KE+ +E K E + D+ + E +E +G+ EE + G + E EE E
Sbjct: 771 EEGERKKEERAGKEEKGEEE----GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826
Query: 259 AEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQ 318
EE E G EE+ + E+E EG EE E GE +G G + G+
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886
Query: 319 TSPSASESSPSDVPQSPPESPSSGEKKEKAPE 350
+ + E GE +E+ E
Sbjct: 887 GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGE 918
Score = 88.6 bits (218), Expect = 1e-17
Identities = 80/273 (29%), Positives = 127/273 (46%), Gaps = 25/273 (9%)
Query: 14 EAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTES-GKQE 72
E E+ E+ EG+ E+G + E G G EE G G+ EG E G++E
Sbjct: 825 EREEEEEEGEGE-EEEGEGEEEEGEGEEEEGEGKGEEE--GEEGEGEEEGEEGEGEGEEE 881
Query: 73 KAPAE-----DGMSAELQGEANGLDEVKVESQREAG-GKEDAEAELKKEDGEKEETTVGS 126
+ E +G E +GE G +E + E + E G GK + E E + +GE+EE
Sbjct: 882 EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941
Query: 127 QEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEE 186
++ G EE + E E EE+E E + EE E + E G+ + ++ E + EE
Sbjct: 942 EDGEGEGEEEEGE-WEGEEEEG----EGEGEEEGEGEGEEGE----GEGEEEEGEGEGEE 992
Query: 187 EDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGA 246
E+ EE G+ + E E +EE + E + V +E + E +E +G+EE +
Sbjct: 993 EEG-----EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEERE 1047
Query: 247 KE-EADAKEEAEDAEEAEPGSPSEEQEQDVEKE 278
KE E + + EE E G E E++ E++
Sbjct: 1048 KEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080
Score = 85.1 bits (209), Expect = 1e-16
Identities = 86/309 (27%), Positives = 139/309 (44%), Gaps = 26/309 (8%)
Query: 4 GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEG 63
G E++ E +E+ + EG E+G + E G G EE +G + EG
Sbjct: 796 GEEEETEGRGEEKEEGGEVEGGEVEEG---KGEREEEEEEGEG---EEEEGEGEEEEGEG 849
Query: 64 PPTESGKQEKAPAEDGMSAEL--QGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEE 121
E + + E+G E +GE G +E + E G+E+ E E ++E+GE E
Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE-----EGEGEGEEEGEGEGEEEEGEGE- 903
Query: 122 TTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPK 181
G +E G EE + E K EE E + + EE E + E G+ + ++ E +
Sbjct: 904 ---GEEEGEGEGEEEEGEGKGEEEGEE--GEGEGEEEEGEGEGEDGE----GEGEEEEGE 954
Query: 182 ATVEEEDAKTASQEE-TGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPK-EPDGK 239
EEE+ + +EE G+ +E E +E+ + E + E + E+E + E + E +G+
Sbjct: 955 WEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGE 1014
Query: 240 EEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTG 299
EE + + E + +E + EE E EE+E++ E E E EE TG
Sbjct: 1015 EEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGE-ENRRNREEEEEEEGKYQETG 1073
Query: 300 EGHNLSTDG 308
E N DG
Sbjct: 1074 EEENERQDG 1082
Score = 74.3 bits (181), Expect = 2e-13
Identities = 69/267 (25%), Positives = 112/267 (41%), Gaps = 28/267 (10%)
Query: 7 GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPT 66
GE + E + + E +EG+ E+G + E G G EE +G + EG
Sbjct: 849 GEEE-EGEGKGEEEGEEGEGEEEGE--EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGE 905
Query: 67 ESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGS 126
E G+ E E E +GE E + E + G ED E E ++E+GE E
Sbjct: 906 EEGEGEGEEEEGEGKGEEEGEEG---EGEGEEEEGEGEGEDGEGEGEEEEGEWE------ 956
Query: 127 QEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEE 186
G +EE + E +E E E + + EE E G+ + ++ E + EE
Sbjct: 957 ----GEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE-----GEGEEEEGEEEGEEEGEGEE 1007
Query: 187 EDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGA 246
E +EE G E + + EE + E ++ E+E + KE +G+E ++
Sbjct: 1008 EGEGEGEEEEEG-------EVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNRE 1060
Query: 247 KEEADAKEEAEDAEEAEPGSPSEEQEQ 273
+EE + + E EE EE ++
Sbjct: 1061 EEEEEEGKYQETGEEENERQDGEEYKK 1087
Score = 63.2 bits (152), Expect = 6e-10
Identities = 59/221 (26%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 7 GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETK-----GTAGKAIN 61
GE + E + E+ EG+ E+G + E G G EE + G +
Sbjct: 885 GEGEEEGEGEGEEEEGEGEGEEEGE-----GEGEEEEGEGKGEEEGEEGEGEGEEEEGEG 939
Query: 62 EGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEE 121
EG E +E+ +G E +GE E + E G +E+ E E ++E+GE+E
Sbjct: 940 EGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE- 998
Query: 122 TTVGSQEMTGRKE-ETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180
G +E G +E E + E +E E E + E+ + E +E + E + + + E
Sbjct: 999 ---GEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEEN 1055
Query: 181 KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQ 221
+ EEE +EE G+ +E E E+ EE K S+
Sbjct: 1056 RRNREEE------EEEEGKYQETGEEENERQDGEEYKKVSK 1090
>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
sapiens]
Length = 987
Score = 96.7 bits (239), Expect = 5e-20
Identities = 118/516 (22%), Positives = 209/516 (40%), Gaps = 100/516 (19%)
Query: 72 EKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE----DAEAELKKEDGEKEETTVGSQ 127
EK A + + E E+ + E+ ++ E E + EL K +GE + +
Sbjct: 480 EKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVS---- 535
Query: 128 EMTGRKEETKSEPKE-----AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
+ + E+ S KE AE+ T ++KA E +A+ + ++ D+ E
Sbjct: 536 SLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHR 595
Query: 183 TVEEEDAKTASQEETG----QRKECSTEPKEKATDEEAKAESQK-----------AVVED 227
V+ + + S+ E+ + ++ E + K ++ K E+++ VV +
Sbjct: 596 AVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVAN 655
Query: 228 EAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGS---------PSEEQEQDVEKE 278
+ K E ++ + K +EE +A+ + E + G P +E+ + E +
Sbjct: 656 DIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVD 715
Query: 279 PEG---GAGVIPSSPEEWPES---------------PTGEGHNLSTDGLGPDCVASG--- 317
G G V +SP PES P G G N+S P SG
Sbjct: 716 AAGRWPGVCVSRTSPTP-PESATTVKSLIKSFDLGRPGGAGQNISVHKT-PRSPLSGIPV 773
Query: 318 QTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVD----- 372
+T+P+A+ S P + SS + +R+ P P + R +
Sbjct: 774 RTAPAAAVS-----PMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHL 828
Query: 373 ----KFGGAASGPTALFRNTKAAGAAI-------------------------GGVKNMLL 403
+ P+ F +T+ A+ G +N LL
Sbjct: 829 RKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALL 888
Query: 404 EWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFST 463
+WC+ T+ Y ++DI NFSSSWS G+AFCAL+H + P Y EL+ +++ N LAF
Sbjct: 889 KWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEA 948
Query: 464 AEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYR 499
AE + L++ +M+ PD + V Y+ ++Y+
Sbjct: 949 AESVG-IKPSLELSEMLYTDRPDWQSVMQYVAQIYK 983
>gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
sapiens]
Length = 1068
Score = 96.7 bits (239), Expect = 5e-20
Identities = 118/516 (22%), Positives = 209/516 (40%), Gaps = 100/516 (19%)
Query: 72 EKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE----DAEAELKKEDGEKEETTVGSQ 127
EK A + + E E+ + E+ ++ E E + EL K +GE + +
Sbjct: 561 EKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVS---- 616
Query: 128 EMTGRKEETKSEPKE-----AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
+ + E+ S KE AE+ T ++KA E +A+ + ++ D+ E
Sbjct: 617 SLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHR 676
Query: 183 TVEEEDAKTASQEETG----QRKECSTEPKEKATDEEAKAESQK-----------AVVED 227
V+ + + S+ E+ + ++ E + K ++ K E+++ VV +
Sbjct: 677 AVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVAN 736
Query: 228 EAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGS---------PSEEQEQDVEKE 278
+ K E ++ + K +EE +A+ + E + G P +E+ + E +
Sbjct: 737 DIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVD 796
Query: 279 PEG---GAGVIPSSPEEWPES---------------PTGEGHNLSTDGLGPDCVASG--- 317
G G V +SP PES P G G N+S P SG
Sbjct: 797 AAGRWPGVCVSRTSPTP-PESATTVKSLIKSFDLGRPGGAGQNISVHKT-PRSPLSGIPV 854
Query: 318 QTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVD----- 372
+T+P+A+ S P + SS + +R+ P P + R +
Sbjct: 855 RTAPAAAVS-----PMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHL 909
Query: 373 ----KFGGAASGPTALFRNTKAAGAAI-------------------------GGVKNMLL 403
+ P+ F +T+ A+ G +N LL
Sbjct: 910 RKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALL 969
Query: 404 EWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFST 463
+WC+ T+ Y ++DI NFSSSWS G+AFCAL+H + P Y EL+ +++ N LAF
Sbjct: 970 KWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEA 1029
Query: 464 AEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYR 499
AE + L++ +M+ PD + V Y+ ++Y+
Sbjct: 1030 AESVG-IKPSLELSEMLYTDRPDWQSVMQYVAQIYK 1064
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 94.0 bits (232), Expect = 3e-19
Identities = 96/346 (27%), Positives = 156/346 (45%), Gaps = 41/346 (11%)
Query: 72 EKAPAEDGMSAELQGEANGLDEVKVESQREA----GGKEDAEAELKKEDGEKEETTVGSQ 127
EK+ E + E E +EV E ++EA G +E+ E + E GE+E + ++
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAE 507
Query: 128 EMTGRKEETKSEPKE---------AEEKESTLASEKQKAEEK---EAKPESGQKADANDR 175
E ++E KS KE + EKE + + K+ EK AK E+ +A
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 176 DKPEPKATVE---EEDAKTASQEETGQRKECSTEPKEKA-TDEEAKAESQ-KAVVEDEAK 230
+K E K+ E E AK+ ++EE E + K K+ EEAK+ ++ K+ V++EAK
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627
Query: 231 --AEPKEPD-----GKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGA 283
AE K P+ KEEAK K ++ KEEA+ E+A+ +E + + K P
Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687
Query: 284 GVIP----SSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESP 339
P S +E +SP + + P+ SP E+ + +SP +
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE----KAKSPVKEEAKTPEKAKSPVKEE 743
Query: 340 SSGEKKEKAPERR----VSAPARPRGPRAQNRKAIVDKFGGAASGP 381
+ +K K+PE+ V +P + P + ++ DKF A P
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSP-EAKTPAKEEARSPADKFPEKAKSP 788
Score = 92.4 bits (228), Expect = 9e-19
Identities = 98/360 (27%), Positives = 154/360 (42%), Gaps = 31/360 (8%)
Query: 20 EQKEGKLSEDGTTVSPA--ADNPEMSGGGAPAEETKGTAGKAINEGP----PTESGKQEK 73
E++E + E+ T PA A +PE EE K A E P E EK
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query: 74 APAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRK 133
A + A+ EA ++ + +S E E A++ K+E E + + K
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609
Query: 134 EETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTAS 193
EE KS AE K K AE K PE + + PE + E+E+AK+
Sbjct: 610 EEAKSP---AEAKSPVKEEAKSPAEVKS--PEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664
Query: 194 QEETGQRKECSTEPKEKA-TDEEAKA-ESQKAVVEDEAKAEPKEPDG-KEEAKHGAKEEA 250
+ ++ + E + K K+ EAK+ E K+ V++EAK+ K KEEAK K ++
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKS 724
Query: 251 DAKEEAEDAEEAEPGSPSEEQEQDVE--KEPEGGAGVIPSSPEEWPESPTGEGHNLSTDG 308
KEEA+ E+A+ SP +E+ + E K PE + SPE ++P E D
Sbjct: 725 PVKEEAKTPEKAK--SPVKEEAKSPEKAKSPEKAKTLDVKSPE--AKTPAKEEARSPADK 780
Query: 309 LGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRK 368
P ++S + +SP ++ S ++ KAPE+ + + P + K
Sbjct: 781 F-----------PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Score = 90.5 bits (223), Expect = 3e-18
Identities = 101/385 (26%), Positives = 165/385 (42%), Gaps = 40/385 (10%)
Query: 8 ESDCSAEAREKMEQKEGKLSEDGTTVSPA-ADNPEMSGGGAPAE-----ETKGTAGKAIN 61
E+ AEA+ E+ + + E+ SPA A +P +PAE + K +
Sbjct: 591 EAKSPAEAKSP-EKAKSPVKEEAK--SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAK 647
Query: 62 EGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEE 121
+S ++E+A + + + ++ EA ++ K + EA E A++ +K+E E+
Sbjct: 648 SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK 707
Query: 122 TTVGSQEMTGRKEETKSEPKE---AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKP 178
+E E+ KS KE EK + E+ K+ EK PE KA D P
Sbjct: 708 AKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPE---KAKTLDVKSP 764
Query: 179 EPKATVEEE----------DAKTASQEETGQRKECSTEPKE--KATDEEA-KAESQKAVV 225
E K +EE AK+ +EE ++ + KE KA ++E K E K+ V
Sbjct: 765 EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824
Query: 226 EDEAKAEP---KEPDGKEEAKHG-----AKEEADAKEEAEDAEEAEPGSPSEEQEQDVEK 277
++E K + KEP K E + +E+ D+K+E +EA E++E VEK
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK 884
Query: 278 EPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPE 337
E E+ + PT E + + D +T + E P D P
Sbjct: 885 PKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE--PDDAKAKEPS 942
Query: 338 SPSSGEKKEKAPERRVSAPARPRGP 362
P+ EKKE APE++ + + + P
Sbjct: 943 KPA--EKKEAAPEKKDTKEEKAKKP 965
Score = 89.7 bits (221), Expect = 6e-18
Identities = 85/370 (22%), Positives = 163/370 (44%), Gaps = 32/370 (8%)
Query: 14 EAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73
E + + Q +++E+ + + E GG EE + G+ + PP E E
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG----EEEEAEGGEEETKSPPAE----EA 509
Query: 74 APAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRK 133
A E + ++ EA E K + EA + ++ K + KEE + + K
Sbjct: 510 ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 134 EETKSEPK-EAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTA 192
EE KS + ++ EK + A E+ K+ + PE + + P + +E+AK+
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629
Query: 193 SQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA----KAEPKEPDG-----KEEAK 243
++ ++ ++ + T+ + K+ ++ E ++A ++A KAE K P+ K EAK
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK 689
Query: 244 HGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHN 303
K ++ KEEA+ E+A+ SP +E+ + EK S +E ++P
Sbjct: 690 SPEKAKSPVKEEAKSPEKAK--SPVKEEAKSPEK--------AKSPVKEEAKTPEKAKSP 739
Query: 304 LSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEK---KEKAP-ERRVSAPARP 359
+ + P+ S + + + SP + E+ S +K K K+P + V +P +
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKA 799
Query: 360 RGPRAQNRKA 369
+ P ++ KA
Sbjct: 800 KSPLKEDAKA 809
Score = 85.5 bits (210), Expect = 1e-16
Identities = 103/392 (26%), Positives = 171/392 (43%), Gaps = 52/392 (13%)
Query: 8 ESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTE 67
+ + + A K +K +++ P A +PE +PAE +
Sbjct: 535 KEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE---------------VK 579
Query: 68 SGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQ 127
S ++ K+PA++ A+ EA ++ K + EA +A++ +K+E E +
Sbjct: 580 SPEKAKSPAKE--EAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
Query: 128 EMTGRKEETKSEPK-EAEEKESTLASEKQKAEEK-EAK-PESGQ---KADANDRDK---P 178
+ KEE KS K ++ EKE + EK K+ K EAK PE + KA+A +K P
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697
Query: 179 EPKATVEEEDAKTASQEETGQRKECSTEPKEKA-TDEEAKA-------ESQKAVVEDEAK 230
+ E AK+ +EE ++ + KE+A T E+AK+ +KA ++AK
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Query: 231 A-EPKEPDGKEEAKHGAKEEAD---------AKEEAEDAEEAEPGSPSEEQEQDVEKE-P 279
+ K P+ K AK A+ AD KEE + E+A+ SP +E + EKE P
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAK--SPLKEDAKAPEKEIP 815
Query: 280 EGGAGVIPSSPEEWP-ESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPES 338
+ P EE P E E + + P A+ +T +S + P+
Sbjct: 816 KKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP---ATPKTE-EKKDSKKEEAPKKEAPK 871
Query: 339 PSSGEKKEKAPERRVSAPARPRGPRAQNRKAI 370
P EKKE A E+ + + A+++K +
Sbjct: 872 PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903
Score = 84.7 bits (208), Expect = 2e-16
Identities = 93/372 (25%), Positives = 158/372 (42%), Gaps = 41/372 (11%)
Query: 12 SAEAREKMEQKEGKLSEDGTT-VSPAADNPEMSGGGAPAEETKGTAGKA-INEGPPTESG 69
S E + E++E K E + V A +PE + AE K+ + E +S
Sbjct: 648 SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE--EAKSP 705
Query: 70 KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETT-VGSQE 128
++ K+P ++ + + ++ +E K + ++ KE+A++ K + EK +T V S E
Sbjct: 706 EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765
Query: 129 M-TGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE 187
T KEE +S + EK + E+ K+ EK P K DA +K PK +E
Sbjct: 766 AKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP---LKEDAKAPEKEIPK----KE 818
Query: 188 DAKTASQEETGQRKECSTEPKEKATDEEA----KAESQKAVVEDEA------------KA 231
+ K+ +EE ++ EP +KA +E+A K E +K ++EA K
Sbjct: 819 EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKK 878
Query: 232 EPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPG-------SPSEEQEQDVEKEPEGGAG 284
EP KE KEEA+ K++ E+ P + +E+ + +KEP+
Sbjct: 879 EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938
Query: 285 VIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSP-----PESP 339
PS P E E+ + P+ + + + S P P +S
Sbjct: 939 KEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSS 998
Query: 340 SSGEKKEKAPER 351
S+ +K K PE+
Sbjct: 999 STDQKDSKPPEK 1010
Score = 84.3 bits (207), Expect = 2e-16
Identities = 84/292 (28%), Positives = 138/292 (47%), Gaps = 25/292 (8%)
Query: 94 VKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASE 153
+KV+S+ + E +E E + + EET V ++E+T EE + E KE E KE E
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEEQTEETQV-TEEVT---EEEEKEAKEEEGKEEE-GGE 490
Query: 154 KQKAEEKEAKPESGQKADANDRDKPEPKATVEEE-----DAKTASQEETGQRKECSTEPK 208
+++AE E + +S +A +K E K+ V+EE +AK+ +EE E + K
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEK-EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query: 209 EKA-TDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEA----- 262
K+ EEAK+ + E E P E E+AK AKEEA + EA+ E+A
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609
Query: 263 EPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQ---- 318
E E + V++E + A V SPE+ +SPT E P+ +
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEV--KSPEK-AKSPTKEEAKSPEKAKSPEKEEAKSPEKA 666
Query: 319 TSPSASESSPSDVPQSPPESPSSGEKKEKAP-ERRVSAPARPRGPRAQNRKA 369
SP +E+ + +SP ++ + +K K+P + +P + + P + K+
Sbjct: 667 KSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718
Score = 80.5 bits (197), Expect = 3e-15
Identities = 74/291 (25%), Positives = 131/291 (45%), Gaps = 30/291 (10%)
Query: 8 ESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINE----- 62
+S EA+ + K + ++ SP A P +PA++ A + E
Sbjct: 737 KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP 796
Query: 63 ----GPPTESGK--QEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELK--- 113
P E K +++ P ++ + + ++ E EVKV+ + +E A A K
Sbjct: 797 EKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP-QEVKVKEPPKKAEEEKAPATPKTEE 855
Query: 114 KEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKP----ESGQK 169
K+D +KEE +E K E K EP + KES + ++K++AE+K+ P E+ K
Sbjct: 856 KKDSKKEEAP--KKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913
Query: 170 ADANDRDKPEPKATV---EEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE 226
+ + KP+ K V E +DAK + ++KE + E K+ +E+AK +K E
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKD-TKEEKAKKPEEKPKTE 972
Query: 227 DEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEK 277
+AK D K +K +K +A+ E++ ++ + P + E K
Sbjct: 973 AKAK-----EDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 60.1 bits (144), Expect = 5e-09
Identities = 62/231 (26%), Positives = 102/231 (44%), Gaps = 25/231 (10%)
Query: 20 EQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEKAPA--- 76
E+ + L ED +P + P+ +P +E + + E P + ++EKAPA
Sbjct: 797 EKAKSPLKEDAK--APEKEIPKKEEVKSPVKEEEKPQEVKVKE--PPKKAEEEKAPATPK 852
Query: 77 --EDGMSAELQGEANGLDEVKVESQREAGGKEDAEA--ELKKEDGEKEETTVGSQEMTGR 132
E S + + + KVE ++E ++ E+ E KKE+ E ++ ++
Sbjct: 853 TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA 912
Query: 133 KEETKSEPKEAE-------EKESTLASEKQK-AEEKEAKPESGQKADANDRDKPEPKATV 184
K E K + K E E + A E K AE+KEA PE + + KPE K
Sbjct: 913 KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK-KPEEKPKT 971
Query: 185 E---EEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAE 232
E +ED KT S+E + + E K +TD++ +KA + AK +
Sbjct: 972 EAKAKEDDKTLSKEPSKPKAE--KAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 56.6 bits (135), Expect = 5e-08
Identities = 62/309 (20%), Positives = 132/309 (42%), Gaps = 41/309 (13%)
Query: 91 LDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEK-EST 149
LD + ++ A+ E+ + + + T + + K+ + + E E++ ++
Sbjct: 297 LDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQAD 356
Query: 150 LASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE-DAKTASQEETGQRKEC----- 203
+AS ++ ++ +A+ + + A + + V+ D + A+ + + +EC
Sbjct: 357 IASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFG 416
Query: 204 ----------------STEPKEKATDE---EAKAESQKAVVEDEAKAEPKEPDGKEEAKH 244
ST K K+ ++ K+E + +VE++ + + EE +
Sbjct: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK 476
Query: 245 GAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNL 304
AKEE +EE + EEAE G E++ + P A +SPE+ +SP E
Sbjct: 477 EAKEEEGKEEEGGEEEEAEGG------EEETKSPPAEEA----ASPEKEAKSPVKEEAKS 526
Query: 305 STDGLGPDCVASGQ----TSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPR 360
+ P+ + SP ++S + +SPPE+ S +++ K+P V +P + +
Sbjct: 527 PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSP-AEVKSPEKAK 585
Query: 361 GPRAQNRKA 369
P + K+
Sbjct: 586 SPAKEEAKS 594
>gi|217330568 EH domain binding protein 1 isoform 1 [Homo sapiens]
Length = 1231
Score = 93.2 bits (230), Expect = 5e-19
Identities = 93/370 (25%), Positives = 153/370 (41%), Gaps = 30/370 (8%)
Query: 141 KEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQR 200
++ E+ + ++++KA + + D D+ + AK+AS E
Sbjct: 191 EDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELIN 250
Query: 201 KECSTEPKEKATDEEAKAESQKAVVEDEAKAEP-KEPDGKEEAKHGAKEEADAKEEAEDA 259
K + EK + A S D A+ P +PD +E E + + ED+
Sbjct: 251 KLNFLDEAEK---DLATVNSNPFDDPDAAELNPFGDPDSEEPIT-----ETASPRKTEDS 302
Query: 260 EEAEPGSPSEE----QEQDVEKEPEGGAGVIPSSPEEWPES---PTGEGHNLSTDGLGPD 312
+P +E Q + EPE + S P+ P L D
Sbjct: 303 FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYAD----- 357
Query: 313 CVASGQTSPSASESSPSDVPQS-PPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIV 371
+S ES+P P+S PP + +E ERRV A P P + ++
Sbjct: 358 --SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKA-PAPPVLSPKTGVL 414
Query: 372 DKFGGAASGPTALFRNTKAAGAAIGGVK----NMLLEWCRAMTKKYEHVDIQNFSSSWSS 427
++ +A + + + G K LL WC+ +TK Y V I NF++SW +
Sbjct: 415 NENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRN 474
Query: 428 GMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDS 487
G++FCA++H F PD DY L+P + N A+ + ++LL+ DMV LA+PD
Sbjct: 475 GLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIG-ISRLLEPSDMVLLAIPDK 533
Query: 488 KCVYTYIQEL 497
V TY+ ++
Sbjct: 534 LTVMTYLYQI 543
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 92.8 bits (229), Expect = 7e-19
Identities = 43/102 (42%), Positives = 58/102 (56%)
Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
K LL WC+ T Y +V++QNF +SW G+A CALIH+ PD DYA+L N
Sbjct: 161 KEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLN 220
Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
AF AEK D ++LD +D+V PD K + TY+ Y +
Sbjct: 221 TAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHA 262
>gi|217330574 EH domain binding protein 1 isoform 3 [Homo sapiens]
Length = 1160
Score = 92.8 bits (229), Expect = 7e-19
Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 30/329 (9%)
Query: 185 EEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE----DEAKAEPKEPDGKE 240
E++D +QEE + TE K + +AE A V D+ A P G
Sbjct: 194 EDDDENRVNQEEKAAK---ITELINKLNFLD-EAEKDLATVNSNPFDDPDAAELNPFGDP 249
Query: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEE----QEQDVEKEPEGGAGVIPSSPEEWPES 296
+++ E A ++ ED+ +P +E Q + EPE + S P+
Sbjct: 250 DSEEPITETASPRK-TEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRK 308
Query: 297 ---PTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQS-PPESPSSGEKKEKAPERR 352
P L D +S ES+P P+S PP + +E ERR
Sbjct: 309 NIRPVDMSKYLYAD-------SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERR 361
Query: 353 VSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVK----NMLLEWCRA 408
V A P P + ++++ +A + + + G K LL WC+
Sbjct: 362 VKRKA-PAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKE 420
Query: 409 MTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLA 468
+TK Y V I NF++SW +G++FCA++H F PD DY L+P + N A+ +
Sbjct: 421 VTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIG 480
Query: 469 DCAQLLDVDDMVRLAVPDSKCVYTYIQEL 497
++LL+ DMV LA+PD V TY+ ++
Sbjct: 481 -ISRLLEPSDMVLLAIPDKLTVMTYLYQI 508
>gi|217330572 EH domain binding protein 1 isoform 3 [Homo sapiens]
Length = 1160
Score = 92.8 bits (229), Expect = 7e-19
Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 30/329 (9%)
Query: 185 EEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE----DEAKAEPKEPDGKE 240
E++D +QEE + TE K + +AE A V D+ A P G
Sbjct: 194 EDDDENRVNQEEKAAK---ITELINKLNFLD-EAEKDLATVNSNPFDDPDAAELNPFGDP 249
Query: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEE----QEQDVEKEPEGGAGVIPSSPEEWPES 296
+++ E A ++ ED+ +P +E Q + EPE + S P+
Sbjct: 250 DSEEPITETASPRK-TEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRK 308
Query: 297 ---PTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQS-PPESPSSGEKKEKAPERR 352
P L D +S ES+P P+S PP + +E ERR
Sbjct: 309 NIRPVDMSKYLYAD-------SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERR 361
Query: 353 VSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVK----NMLLEWCRA 408
V A P P + ++++ +A + + + G K LL WC+
Sbjct: 362 VKRKA-PAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKE 420
Query: 409 MTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLA 468
+TK Y V I NF++SW +G++FCA++H F PD DY L+P + N A+ +
Sbjct: 421 VTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIG 480
Query: 469 DCAQLLDVDDMVRLAVPDSKCVYTYIQEL 497
++LL+ DMV LA+PD V TY+ ++
Sbjct: 481 -ISRLLEPSDMVLLAIPDKLTVMTYLYQI 508
>gi|217330570 EH domain binding protein 1 isoform 2 [Homo sapiens]
Length = 1196
Score = 92.8 bits (229), Expect = 7e-19
Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 30/329 (9%)
Query: 185 EEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVE----DEAKAEPKEPDGKE 240
E++D +QEE + TE K + +AE A V D+ A P G
Sbjct: 194 EDDDENRVNQEEKAAK---ITELINKLNFLD-EAEKDLATVNSNPFDDPDAAELNPFGDP 249
Query: 241 EAKHGAKEEADAKEEAEDAEEAEPGSPSEE----QEQDVEKEPEGGAGVIPSSPEEWPES 296
+++ E A ++ ED+ +P +E Q + EPE + S P+
Sbjct: 250 DSEEPITETASPRK-TEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRK 308
Query: 297 ---PTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQS-PPESPSSGEKKEKAPERR 352
P L D +S ES+P P+S PP + +E ERR
Sbjct: 309 NIRPVDMSKYLYAD-------SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERR 361
Query: 353 VSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVK----NMLLEWCRA 408
V A P P + ++++ +A + + + G K LL WC+
Sbjct: 362 VKRKA-PAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKE 420
Query: 409 MTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLA 468
+TK Y V I NF++SW +G++FCA++H F PD DY L+P + N A+ +
Sbjct: 421 VTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIG 480
Query: 469 DCAQLLDVDDMVRLAVPDSKCVYTYIQEL 497
++LL+ DMV LA+PD V TY+ ++
Sbjct: 481 -ISRLLEPSDMVLLAIPDKLTVMTYLYQI 508
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 92.8 bits (229), Expect = 7e-19
Identities = 43/102 (42%), Positives = 58/102 (56%)
Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
K LL WC+ T Y++V+IQNF SW G+ FCALIH+ P+ DY +L N
Sbjct: 147 KEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLN 206
Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
AF AEK D ++LD +D+V A PD K + TY+ Y +
Sbjct: 207 TAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA 248
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 92.8 bits (229), Expect = 7e-19
Identities = 43/102 (42%), Positives = 58/102 (56%)
Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
K LL WC+ T Y++V+IQNF SW G+ FCALIH+ P+ DY +L N
Sbjct: 147 KEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLN 206
Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
AF AEK D ++LD +D+V A PD K + TY+ Y +
Sbjct: 207 TAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA 248
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 92.8 bits (229), Expect = 7e-19
Identities = 43/102 (42%), Positives = 58/102 (56%)
Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
K LL WC+ T Y++V+IQNF SW G+ FCALIH+ P+ DY +L N
Sbjct: 147 KEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLN 206
Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
AF AEK D ++LD +D+V A PD K + TY+ Y +
Sbjct: 207 TAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA 248
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 92.4 bits (228), Expect = 9e-19
Identities = 99/325 (30%), Positives = 146/325 (44%), Gaps = 50/325 (15%)
Query: 64 PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEET 122
P T S K +K E + +L+ + ++E+ E++ ED ++E+++ EE
Sbjct: 429 PITISSKIQKPKVE---APKLKVQHKFVEEIIEETK-----VEDEKSEMEEALTAITEEL 480
Query: 123 TVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
V +E E K E EAEE+E KA E K E G+K + +++ E
Sbjct: 481 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE-- 538
Query: 183 TVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242
E+E AK+ EE G KE S+E KE+ EE E EA+AE +E + KEE
Sbjct: 539 --EDEGAKSDQAEEGGSEKEGSSE-KEEGEQEEG---------ETEAEAEGEEAEAKEEK 586
Query: 243 KHGAKEE---------ADAK-EEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSS 289
K K E ADAK E+ E A+ P SP EE+ + V K P E G +P S
Sbjct: 587 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 646
Query: 290 P-EEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSS------G 342
P EE +SP + + G P + E + S VP+SP E S G
Sbjct: 647 PVEEKGKSPVPKS-PVEEKGKSP------VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 699
Query: 343 EKKEKAPERRVSAPARPRGPRAQNR 367
E+KE+ + AP + + + +
Sbjct: 700 EQKEEEEKEVKEAPKEEKVEKKEEK 724
Score = 75.5 bits (184), Expect = 1e-13
Identities = 81/334 (24%), Positives = 142/334 (42%), Gaps = 42/334 (12%)
Query: 70 KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM 129
+ EK+ E+ ++A + A + E K +EA +++ E E ++E+ +++ V +
Sbjct: 463 EDEKSEMEEALTAITEELAVSMKEEK----KEAAEEKEEEPEAEEEEVAAKKSPVKATAP 518
Query: 130 TGRKEETKSEPKEA--EEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE 187
++EE + E +E EE+E ++ +AEE ++ E + + ++++ E +A E E
Sbjct: 519 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 578
Query: 188 DAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK 247
+A+ +++ ++ E E AT EE A+ A VE KA K P K + K
Sbjct: 579 EAEAKEEKKVEEKSE------EVATKEELVAD---AKVEKPEKA--KSPVPKSPVEEKGK 627
Query: 248 EEADAKEEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSSPEE------WPESPT 298
E + P SP EE+ + V K P E G + SP E P+SP
Sbjct: 628 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 687
Query: 299 GEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPAR 358
E + + G G E +V ++P E EK EK E+ P +
Sbjct: 688 EEAKSKAEVGKG-----------EQKEEEEKEVKEAPKE-----EKVEKKEEKPKDVPEK 731
Query: 359 PRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAG 392
+ +A+ + S L + TK G
Sbjct: 732 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 765
Score = 74.7 bits (182), Expect = 2e-13
Identities = 94/348 (27%), Positives = 145/348 (41%), Gaps = 27/348 (7%)
Query: 15 AREKMEQKEGKLSEDGTTVSPA-ADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73
A EK E+ E + E SP A PE+ EE +G + + +E
Sbjct: 492 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 551
Query: 74 APAEDGMSAELQGEAN-GLDEVKVESQREAGGKEDAEAELKKED-GEKEETTVGSQEMTG 131
++G S + +GE G E + E + EA KE+ + E K E+ KEE ++
Sbjct: 552 GSEKEGSSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAK--VE 608
Query: 132 RKEETKSE-PKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDA 189
+ E+ KS PK E++ K EEK P K+ ++ K P PK+ VEE+
Sbjct: 609 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGK 666
Query: 190 KTASQEETGQRKECSTEPKEKATDEEAKAE----SQKAVVEDEAKAEPKEP--DGKEEAK 243
S+ + K S PK + ++KAE QK E E K PKE + KEE
Sbjct: 667 SPVSKSPV-EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 725
Query: 244 HGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKE-PEGGAGVIPSSPEEWPESPTGEGH 302
E+ A+ ++ AE + ++ + +EKE E G P E+ E GEG
Sbjct: 726 KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK---PLQQEKEKEKAGGEG- 781
Query: 303 NLSTDGLGPDCVASGQTSPSAS---ESSPSDVPQSPPESPSSGEKKEK 347
++ G D A G + E + + + SG ++EK
Sbjct: 782 --GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 827
Score = 72.0 bits (175), Expect = 1e-12
Identities = 84/300 (28%), Positives = 129/300 (43%), Gaps = 43/300 (14%)
Query: 5 AVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGP 64
A+ E + EK E E K E P A+ E++ +P + T +
Sbjct: 475 AITEELAVSMKEEKKEAAEEKEEE------PEAEEEEVAAKKSPVKATAPEVKE------ 522
Query: 65 PTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTV 124
E G++E+ E+G Q E DE Q E GG E E +KE+GE+EE
Sbjct: 523 --EEGEKEE---EEG-----QEEEEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEG-- 569
Query: 125 GSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK---PEPK 181
+ E ++E +EAE KE EK +EE K E A +K P PK
Sbjct: 570 --------ETEAEAEGEEAEAKEEKKVEEK--SEEVATKEELVADAKVEKPEKAKSPVPK 619
Query: 182 ATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEE 241
+ VEE+ K+ + + K S PK +E+ K+ K+ VE++ K+ + +E+
Sbjct: 620 SPVEEK-GKSPVPKSPVEEKGKSPVPK-SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 677
Query: 242 AKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEP-EGGAGVIPSSPEEWPESPTGE 300
AK + EEA+ E G EE+E++V++ P E P++ PE E
Sbjct: 678 AKSPVPK--SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 735
Score = 66.6 bits (161), Expect = 5e-11
Identities = 79/319 (24%), Positives = 128/319 (40%), Gaps = 60/319 (18%)
Query: 7 GESDCSAEAREKMEQKEGKLSEDGTTVSPA--------ADNPEMSGGGAPAEETKGTAGK 58
GE++ AE E ++E K+ E V+ + PE + P +
Sbjct: 569 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 628
Query: 59 AINEGPPTESGKQE--KAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKED 116
+ + P E GK K+P E+ + + +S E GK +E
Sbjct: 629 PVPKSPVEEKGKSPVPKSPVEEKGKSPVP-----------KSPVEEKGKSPVSKSPVEEK 677
Query: 117 GEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRD 176
+ +E + E K E KE EEKE A +++K E+KE KP+ D ++
Sbjct: 678 AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK-----DVPEKK 732
Query: 177 KPEPKATVEEE----------DAKTASQEETGQRKECSTEPKEK-------ATDEEAKAE 219
K E + V+EE K ++ET + + + KEK ++EE +
Sbjct: 733 KAE--SPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 790
Query: 220 SQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAE----------DAEEAEPGSPSE 269
K +++ A E +GKEE + KE+ +EE + A+E + G SE
Sbjct: 791 GAKGSRKEDI-AVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSE 849
Query: 270 EQ---EQDVEK-EPEGGAG 284
E+ + VEK EGG G
Sbjct: 850 EKVVVTKTVEKITSEGGDG 868
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 92.4 bits (228), Expect = 9e-19
Identities = 99/325 (30%), Positives = 146/325 (44%), Gaps = 50/325 (15%)
Query: 64 PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEET 122
P T S K +K E + +L+ + ++E+ E++ ED ++E+++ EE
Sbjct: 53 PITISSKIQKPKVE---APKLKVQHKFVEEIIEETK-----VEDEKSEMEEALTAITEEL 104
Query: 123 TVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
V +E E K E EAEE+E KA E K E G+K + +++ E
Sbjct: 105 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE-- 162
Query: 183 TVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242
E+E AK+ EE G KE S+E KE+ EE E EA+AE +E + KEE
Sbjct: 163 --EDEGAKSDQAEEGGSEKEGSSE-KEEGEQEEG---------ETEAEAEGEEAEAKEEK 210
Query: 243 KHGAKEE---------ADAK-EEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSS 289
K K E ADAK E+ E A+ P SP EE+ + V K P E G +P S
Sbjct: 211 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270
Query: 290 P-EEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSS------G 342
P EE +SP + + G P + E + S VP+SP E S G
Sbjct: 271 PVEEKGKSPVPKS-PVEEKGKSP------VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 323
Query: 343 EKKEKAPERRVSAPARPRGPRAQNR 367
E+KE+ + AP + + + +
Sbjct: 324 EQKEEEEKEVKEAPKEEKVEKKEEK 348
Score = 75.5 bits (184), Expect = 1e-13
Identities = 81/334 (24%), Positives = 142/334 (42%), Gaps = 42/334 (12%)
Query: 70 KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM 129
+ EK+ E+ ++A + A + E K +EA +++ E E ++E+ +++ V +
Sbjct: 87 EDEKSEMEEALTAITEELAVSMKEEK----KEAAEEKEEEPEAEEEEVAAKKSPVKATAP 142
Query: 130 TGRKEETKSEPKEA--EEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEE 187
++EE + E +E EE+E ++ +AEE ++ E + + ++++ E +A E E
Sbjct: 143 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 202
Query: 188 DAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK 247
+A+ +++ ++ E E AT EE A+ A VE KA K P K + K
Sbjct: 203 EAEAKEEKKVEEKSE------EVATKEELVAD---AKVEKPEKA--KSPVPKSPVEEKGK 251
Query: 248 EEADAKEEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSSPEE------WPESPT 298
E + P SP EE+ + V K P E G + SP E P+SP
Sbjct: 252 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 311
Query: 299 GEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPAR 358
E + + G G E +V ++P E EK EK E+ P +
Sbjct: 312 EEAKSKAEVGKG-----------EQKEEEEKEVKEAPKE-----EKVEKKEEKPKDVPEK 355
Query: 359 PRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAG 392
+ +A+ + S L + TK G
Sbjct: 356 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 389
Score = 74.7 bits (182), Expect = 2e-13
Identities = 94/348 (27%), Positives = 145/348 (41%), Gaps = 27/348 (7%)
Query: 15 AREKMEQKEGKLSEDGTTVSPA-ADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73
A EK E+ E + E SP A PE+ EE +G + + +E
Sbjct: 116 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 175
Query: 74 APAEDGMSAELQGEAN-GLDEVKVESQREAGGKEDAEAELKKED-GEKEETTVGSQEMTG 131
++G S + +GE G E + E + EA KE+ + E K E+ KEE ++
Sbjct: 176 GSEKEGSSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAK--VE 232
Query: 132 RKEETKSE-PKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDA 189
+ E+ KS PK E++ K EEK P K+ ++ K P PK+ VEE+
Sbjct: 233 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGK 290
Query: 190 KTASQEETGQRKECSTEPKEKATDEEAKAE----SQKAVVEDEAKAEPKEP--DGKEEAK 243
S+ + K S PK + ++KAE QK E E K PKE + KEE
Sbjct: 291 SPVSKSPV-EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 349
Query: 244 HGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKE-PEGGAGVIPSSPEEWPESPTGEGH 302
E+ A+ ++ AE + ++ + +EKE E G P E+ E GEG
Sbjct: 350 KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK---PLQQEKEKEKAGGEG- 405
Query: 303 NLSTDGLGPDCVASGQTSPSAS---ESSPSDVPQSPPESPSSGEKKEK 347
++ G D A G + E + + + SG ++EK
Sbjct: 406 --GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
Score = 72.0 bits (175), Expect = 1e-12
Identities = 84/300 (28%), Positives = 129/300 (43%), Gaps = 43/300 (14%)
Query: 5 AVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGP 64
A+ E + EK E E K E P A+ E++ +P + T +
Sbjct: 99 AITEELAVSMKEEKKEAAEEKEEE------PEAEEEEVAAKKSPVKATAPEVKE------ 146
Query: 65 PTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTV 124
E G++E+ E+G Q E DE Q E GG E E +KE+GE+EE
Sbjct: 147 --EEGEKEE---EEG-----QEEEEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEG-- 193
Query: 125 GSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK---PEPK 181
+ E ++E +EAE KE EK +EE K E A +K P PK
Sbjct: 194 --------ETEAEAEGEEAEAKEEKKVEEK--SEEVATKEELVADAKVEKPEKAKSPVPK 243
Query: 182 ATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEE 241
+ VEE+ K+ + + K S PK +E+ K+ K+ VE++ K+ + +E+
Sbjct: 244 SPVEEK-GKSPVPKSPVEEKGKSPVPK-SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 301
Query: 242 AKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEP-EGGAGVIPSSPEEWPESPTGE 300
AK + EEA+ E G EE+E++V++ P E P++ PE E
Sbjct: 302 AKSPVPK--SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
Score = 66.6 bits (161), Expect = 5e-11
Identities = 79/319 (24%), Positives = 128/319 (40%), Gaps = 60/319 (18%)
Query: 7 GESDCSAEAREKMEQKEGKLSEDGTTVSPA--------ADNPEMSGGGAPAEETKGTAGK 58
GE++ AE E ++E K+ E V+ + PE + P +
Sbjct: 193 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 252
Query: 59 AINEGPPTESGKQE--KAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKED 116
+ + P E GK K+P E+ + + +S E GK +E
Sbjct: 253 PVPKSPVEEKGKSPVPKSPVEEKGKSPVP-----------KSPVEEKGKSPVSKSPVEEK 301
Query: 117 GEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRD 176
+ +E + E K E KE EEKE A +++K E+KE KP+ D ++
Sbjct: 302 AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK-----DVPEKK 356
Query: 177 KPEPKATVEEE----------DAKTASQEETGQRKECSTEPKEK-------ATDEEAKAE 219
K E + V+EE K ++ET + + + KEK ++EE +
Sbjct: 357 KAE--SPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414
Query: 220 SQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAE----------DAEEAEPGSPSE 269
K +++ A E +GKEE + KE+ +EE + A+E + G SE
Sbjct: 415 GAKGSRKEDI-AVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSE 473
Query: 270 EQ---EQDVEK-EPEGGAG 284
E+ + VEK EGG G
Sbjct: 474 EKVVVTKTVEKITSEGGDG 492
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 90.9 bits (224), Expect = 3e-18
Identities = 48/108 (44%), Positives = 60/108 (55%), Gaps = 1/108 (0%)
Query: 391 AGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDP 450
A AA+ K LL WC+ T Y +V+I +FS SWS G+ F ALIH PD DY L P
Sbjct: 137 ASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRP 196
Query: 451 AKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY 498
+ HN AF AE+ AQLLD +D V A PD + + TY+ Y
Sbjct: 197 DRPLHNLAFAFLVAEQELGIAQLLDPED-VAAAQPDERSIMTYVSLYY 243
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 89.0 bits (219), Expect = 1e-17
Identities = 41/102 (40%), Positives = 58/102 (56%)
Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
K LL WC+ T Y +V+IQNF +SW G+ CALIH+ PD DY++L+ N
Sbjct: 154 KEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNIN 213
Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
LA AEK D ++LD +D+V PD + + TY+ Y +
Sbjct: 214 LAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHA 255
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
[Homo sapiens]
Length = 2564
Score = 87.8 bits (216), Expect = 2e-17
Identities = 43/100 (43%), Positives = 61/100 (61%), Gaps = 1/100 (1%)
Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
K+ LL WC+ T Y V+IQNF++SW G+AF ALIH+ PD D+++L + +N
Sbjct: 183 KDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQ 242
Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY 498
AF TAE+ A+LLD +D V + PD K + TY+ Y
Sbjct: 243 RAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFY 281
Score = 31.6 bits (70), Expect = 1.8
Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 3/64 (4%)
Query: 317 GQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQ--NRKAIVDKF 374
G+ P+A ++P D ++P +P++ E+ PER+ SA PR + R+ VD+
Sbjct: 2200 GRVEPAALPAAPEDAAETPA-TPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQS 2258
Query: 375 GGAA 378
AA
Sbjct: 2259 EEAA 2262
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 87.4 bits (215), Expect = 3e-17
Identities = 45/107 (42%), Positives = 59/107 (55%), Gaps = 1/107 (0%)
Query: 392 GAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPA 451
G K+ LL WC+ T Y HV++ NF+SSW G+AF ALIHK PD D+ +L +
Sbjct: 169 GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDS 228
Query: 452 KRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY 498
RHN AF+ AE+ LLD +D V PD K + TY+ Y
Sbjct: 229 NARHNLEHAFNVAERQLGIIPLLDPED-VFTENPDEKSIITYVVAFY 274
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 87.4 bits (215), Expect = 3e-17
Identities = 45/107 (42%), Positives = 59/107 (55%), Gaps = 1/107 (0%)
Query: 392 GAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPA 451
G K+ LL WC+ T Y HV++ NF+SSW G+AF ALIHK PD D+ +L +
Sbjct: 169 GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDS 228
Query: 452 KRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY 498
RHN AF+ AE+ LLD +D V PD K + TY+ Y
Sbjct: 229 NARHNLEHAFNVAERQLGIIPLLDPED-VFTENPDEKSIITYVVAFY 274
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 86.7 bits (213), Expect = 5e-17
Identities = 41/102 (40%), Positives = 58/102 (56%)
Query: 399 KNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFT 458
K LL WC+ T Y++V++QNF SW G+AF ALIH+ P+ +Y +L N
Sbjct: 166 KEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLN 225
Query: 459 LAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRS 500
AF AEK D ++LD +D+V A PD K + TY+ Y +
Sbjct: 226 NAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHA 267
>gi|31324577 molecule interacting with Rab13 [Homo sapiens]
Length = 863
Score = 86.3 bits (212), Expect = 6e-17
Identities = 42/111 (37%), Positives = 60/111 (54%)
Query: 395 IGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRR 454
+ G + LL WCR + Y V+I++ SSS+ G+AFCA++H+ PD D+ L
Sbjct: 1 MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLDFDSLSKDNVF 60
Query: 455 HNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRSLVQKG 505
N LAF AEK LLD +DMV ++VPD + TY+ + Y G
Sbjct: 61 ENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFCSPG 111
Score = 45.4 bits (106), Expect = 1e-04
Identities = 78/378 (20%), Positives = 133/378 (35%), Gaps = 53/378 (14%)
Query: 48 PAEETKGTAGKAINEGPPTESG------KQEKAPAEDGMSAELQGEANGLDEVKVESQRE 101
P E T A GP T SG Q K + ++ + + G + E
Sbjct: 207 PEEGTFVCAEHCARLGPGTRSGTRPGPFSQPKQQHQQQLAEDAKDVPGGGPSSSAPAGAE 266
Query: 102 AGGKEDAEAELKKEDGEKEETTVGSQEMT----GRKEETKSEPKEAEEKESTLASEKQKA 157
A G + A E + + K QE+ GR + E+ +
Sbjct: 267 ADGPK-ASPEARPQIPTKPRVPGKLQELASPPAGRPTPAPRKASESTTPAPPTPRPRSSL 325
Query: 158 EEKEAKPESGQKADANDR----DKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATD 213
+++ ++G + N R P+P+ T + + A +++ EPK+K
Sbjct: 326 QQENLVEQAGSSSLVNGRLHELPVPKPRGTPKPSEGTPAPRKDPPWITLVQAEPKKKP-- 383
Query: 214 EEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQ 273
A + + P D ++ G +E A A + E++P +P EE+E+
Sbjct: 384 ---------APLPPSSSPGPPSQDSRQVENGGTEEVAQPSPTA--SLESKPYNPFEEEEE 432
Query: 274 DVEKEPEGGAGVIPS----SPEEWPES--------PTGEGHNLSTDGLGPDCVASGQTSP 321
D E+E + S PE P+S PT P ++ +
Sbjct: 433 DKEEEAPAAPSLATSPALGHPESTPKSLHPWYGITPTSSPKTKKRP--APRAPSASPLAL 490
Query: 322 SASESSPSDVPQSPP------ESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFG 375
AS S S+ P + P ES SS + A + PA P++ + A+
Sbjct: 491 HASRLSHSEPPSATPSPALSVESLSSESASQTAGAELLEPPA---VPKSSSEPAV--HAP 545
Query: 376 GAASGPTALFRNTKAAGA 393
G P +L N+ A +
Sbjct: 546 GTPGNPVSLSTNSSLASS 563
Score = 35.0 bits (79), Expect = 0.16
Identities = 33/147 (22%), Positives = 56/147 (38%), Gaps = 18/147 (12%)
Query: 214 EEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQ 273
E E E A+ P G ++ ++ AEDA++ G PS
Sbjct: 204 ENGPEEGTFVCAEHCARLGPGTRSGTRPGPFSQPKQQHQQQLAEDAKDVPGGGPSSSAPA 263
Query: 274 DVEKEPEGGAGVIPSSPEEWPESPT-----GEGHNLSTDGLGPDCVASGQTSPSASESSP 328
E + +SPE P+ PT G+ L++ +G+ +P+ ++S
Sbjct: 264 GAEADGP------KASPEARPQIPTKPRVPGKLQELASP-------PAGRPTPAPRKASE 310
Query: 329 SDVPQSPPESPSSGEKKEKAPERRVSA 355
S P P P S ++E E+ S+
Sbjct: 311 STTPAPPTPRPRSSLQQENLVEQAGSS 337
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.300 0.121 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,054,998
Number of Sequences: 37866
Number of extensions: 1458679
Number of successful extensions: 39452
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 940
Number of HSP's successfully gapped in prelim test: 1924
Number of HSP's that attempted gapping in prelim test: 9566
Number of HSP's gapped (non-prelim): 12975
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.