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Search of human proteins with 157388993
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
(145 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 291 1e-79
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 87 4e-18
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 87 4e-18
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 86 1e-17
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 86 1e-17
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 86 1e-17
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 86 1e-17
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 86 1e-17
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 86 1e-17
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 74 6e-14
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 74 6e-14
gi|148746189 multiple PDZ domain protein [Homo sapiens] 73 7e-14
gi|45827729 scribble isoform b [Homo sapiens] 71 4e-13
gi|45827731 scribble isoform a [Homo sapiens] 71 4e-13
gi|112382257 InaD-like [Homo sapiens] 67 5e-12
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 66 1e-11
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 65 3e-11
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 65 3e-11
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 65 3e-11
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 65 3e-11
gi|87196343 PDZ domain containing 2 [Homo sapiens] 64 6e-11
gi|4759306 lin-7 homolog A [Homo sapiens] 62 2e-10
gi|11545920 lin-7 homolog B [Homo sapiens] 62 2e-10
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 62 2e-10
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 61 3e-10
gi|8922944 lin-7 homolog C [Homo sapiens] 61 4e-10
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 60 5e-10
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 60 5e-10
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 60 6e-10
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 60 6e-10
>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
Length = 145
Score = 291 bits (746), Expect = 1e-79
Identities = 145/145 (100%), Positives = 145/145 (100%)
Query: 1 MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQ 60
MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQ
Sbjct: 1 MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQ 60
Query: 61 EGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPI 120
EGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPI
Sbjct: 61 EGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPI 120
Query: 121 FMVLVPVFALTMVAAWAFMRYRQQL 145
FMVLVPVFALTMVAAWAFMRYRQQL
Sbjct: 121 FMVLVPVFALTMVAAWAFMRYRQQL 145
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 87.4 bits (215), Expect = 4e-18
Identities = 43/84 (51%), Positives = 58/84 (69%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
EI L +GP GLGF+I GG Q++ D+ IYV++I E GAA DGRLQ GDKIL+VN
Sbjct: 203 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 262
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRV 96
L++++H+DAV +N V L+V
Sbjct: 263 LEDVMHEDAVAALKNTYDVVYLKV 286
Score = 83.6 bits (205), Expect = 5e-17
Identities = 44/97 (45%), Positives = 60/97 (61%), Gaps = 4/97 (4%)
Query: 3 GRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEG 62
G ++Y EEI L RG SGLGF+I GGTD ++ +D I++++I GAAA DGRL+
Sbjct: 102 GEMEY----EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVN 157
Query: 63 DKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
D IL VN D++ + H AV+ + AG V L V R
Sbjct: 158 DSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 194
Score = 75.5 bits (184), Expect = 1e-14
Identities = 42/97 (43%), Positives = 57/97 (58%), Gaps = 6/97 (6%)
Query: 3 GRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEG 62
G D I + RG +GLGFNIVGG D + GI++S I G A L G L++G
Sbjct: 346 GEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGELRKG 399
Query: 63 DKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
D+ILSVNG DL+N H+ A +NAG V++ Q++
Sbjct: 400 DQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYK 436
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 87.4 bits (215), Expect = 4e-18
Identities = 43/84 (51%), Positives = 58/84 (69%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
EI L +GP GLGF+I GG Q++ D+ IYV++I E GAA DGRLQ GDKIL+VN
Sbjct: 157 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 216
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRV 96
L++++H+DAV +N V L+V
Sbjct: 217 LEDVMHEDAVAALKNTYDVVYLKV 240
Score = 83.6 bits (205), Expect = 5e-17
Identities = 44/97 (45%), Positives = 60/97 (61%), Gaps = 4/97 (4%)
Query: 3 GRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEG 62
G ++Y EEI L RG SGLGF+I GGTD ++ +D I++++I GAAA DGRL+
Sbjct: 56 GEMEY----EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVN 111
Query: 63 DKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
D IL VN D++ + H AV+ + AG V L V R
Sbjct: 112 DSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 148
Score = 75.5 bits (184), Expect = 1e-14
Identities = 42/97 (43%), Positives = 57/97 (58%), Gaps = 6/97 (6%)
Query: 3 GRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEG 62
G D I + RG +GLGFNIVGG D + GI++S I G A L G L++G
Sbjct: 300 GEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGELRKG 353
Query: 63 DKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
D+ILSVNG DL+N H+ A +NAG V++ Q++
Sbjct: 354 DQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYK 390
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 85.9 bits (211), Expect = 1e-17
Identities = 44/91 (48%), Positives = 60/91 (65%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
EEI L RG SGLGF+I GGTD ++ +DS I++++I GAAA DGRL+ D IL VN
Sbjct: 223 EEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEV 282
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRVQHRLQV 102
D++++ H AV+ + AG V L V+ R V
Sbjct: 283 DVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Score = 82.4 bits (202), Expect = 1e-16
Identities = 40/84 (47%), Positives = 56/84 (66%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
EI L +GP GLGF+I GG Q++ D+ IYV++I E GAA DG+LQ GDK+L+VN
Sbjct: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRV 96
L+ + H++AV +N V L+V
Sbjct: 379 LEEVTHEEAVTALKNTSDFVYLKV 402
Score = 73.2 bits (178), Expect = 7e-14
Identities = 39/87 (44%), Positives = 55/87 (63%), Gaps = 6/87 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
++ L RG +GLGFNIVGG D + GI++S I G A L G L++GD+I+SVN D
Sbjct: 466 KVVLHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGELRKGDRIISVNSVD 519
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQHR 99
L+ H+ A +NAG AV++ Q+R
Sbjct: 520 LRAASHEQAAAALKNAGQAVTIVAQYR 546
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 85.9 bits (211), Expect = 1e-17
Identities = 44/91 (48%), Positives = 60/91 (65%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
EEI L RG SGLGF+I GGTD ++ +DS I++++I GAAA DGRL+ D IL VN
Sbjct: 223 EEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEV 282
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRVQHRLQV 102
D++++ H AV+ + AG V L V+ R V
Sbjct: 283 DVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Score = 82.4 bits (202), Expect = 1e-16
Identities = 40/84 (47%), Positives = 56/84 (66%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
EI L +GP GLGF+I GG Q++ D+ IYV++I E GAA DG+LQ GDK+L+VN
Sbjct: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRV 96
L+ + H++AV +N V L+V
Sbjct: 379 LEEVTHEEAVTALKNTSDFVYLKV 402
Score = 73.2 bits (178), Expect = 7e-14
Identities = 39/87 (44%), Positives = 55/87 (63%), Gaps = 6/87 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
++ L RG +GLGFNIVGG D + GI++S I G A L G L++GD+I+SVN D
Sbjct: 466 KVVLHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGELRKGDRIISVNSVD 519
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQHR 99
L+ H+ A +NAG AV++ Q+R
Sbjct: 520 LRAASHEQAAAALKNAGQAVTIVAQYR 546
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 85.5 bits (210), Expect = 1e-17
Identities = 39/84 (46%), Positives = 59/84 (70%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
E+NL +GP GLGF+I GG Q++ D+ IY+++I E GAA DGRLQ GD++L+VN +
Sbjct: 226 EVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTN 285
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRV 96
L+++ H++AV +N V L+V
Sbjct: 286 LQDVRHEEAVASLKNTSDMVYLKV 309
Score = 81.6 bits (200), Expect = 2e-16
Identities = 43/94 (45%), Positives = 59/94 (62%)
Query: 6 DYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKI 65
D + EEI L RG SGLGF+I GG D +V +D GI++++I GAAA+DGRL D +
Sbjct: 124 DGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCV 183
Query: 66 LSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
L VN D+ ++H AV+ + AG V L V+ R
Sbjct: 184 LRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRR 217
Score = 74.7 bits (182), Expect = 3e-14
Identities = 41/94 (43%), Positives = 57/94 (60%), Gaps = 6/94 (6%)
Query: 6 DYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKI 65
D+ +I L +G +GLGFNIVGG D + GI+VS I G A L G L+ GD+I
Sbjct: 379 DFTREPRKIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRI 432
Query: 66 LSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
LSVNG +L+N H+ A + AG +V++ Q+R
Sbjct: 433 LSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYR 466
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 85.5 bits (210), Expect = 1e-17
Identities = 41/89 (46%), Positives = 58/89 (65%)
Query: 8 LVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILS 67
L T EI L +GP GLGF+I GG Q++ D+ IYV++I + GAA DGRLQ GD++L
Sbjct: 137 LETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 196
Query: 68 VNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
VN L+ + H++AV + +N V L+V
Sbjct: 197 VNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
Score = 84.0 bits (206), Expect = 4e-17
Identities = 43/88 (48%), Positives = 57/88 (64%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
EEI L RG SGLGF+I GGTD ++ +D GI++++I GAAA DGRL+ D IL VN
Sbjct: 46 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 105
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
D+ + H AV+ + AG V L V+ R
Sbjct: 106 DVSEVSHSKAVEALKEAGSIVRLYVRRR 133
Score = 71.2 bits (173), Expect = 3e-13
Identities = 39/87 (44%), Positives = 53/87 (60%), Gaps = 6/87 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
++ L +G +GLGFNIVGG D + GI+VS I G A L G LQ GD+ILSVNG D
Sbjct: 318 KVVLHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQHR 99
L+ H+ A + AG V++ Q++
Sbjct: 372 LRGASHEQAAAALKGAGQTVTIIAQYQ 398
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 85.5 bits (210), Expect = 1e-17
Identities = 41/89 (46%), Positives = 58/89 (65%)
Query: 8 LVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILS 67
L T EI L +GP GLGF+I GG Q++ D+ IYV++I + GAA DGRLQ GD++L
Sbjct: 293 LETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 352
Query: 68 VNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
VN L+ + H++AV + +N V L+V
Sbjct: 353 VNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
Score = 84.0 bits (206), Expect = 4e-17
Identities = 43/88 (48%), Positives = 57/88 (64%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
EEI L RG SGLGF+I GGTD ++ +D GI++++I GAAA DGRL+ D IL VN
Sbjct: 202 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 261
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
D+ + H AV+ + AG V L V+ R
Sbjct: 262 DVSEVSHSKAVEALKEAGSIVRLYVRRR 289
Score = 71.2 bits (173), Expect = 3e-13
Identities = 39/87 (44%), Positives = 53/87 (60%), Gaps = 6/87 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
++ L +G +GLGFNIVGG D + GI+VS I G A L G LQ GD+ILSVNG D
Sbjct: 526 KVVLHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELQRGDQILSVNGID 579
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQHR 99
L+ H+ A + AG V++ Q++
Sbjct: 580 LRGASHEQAAAALKGAGQTVTIIAQYQ 606
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 85.5 bits (210), Expect = 1e-17
Identities = 41/89 (46%), Positives = 58/89 (65%)
Query: 8 LVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILS 67
L T EI L +GP GLGF+I GG Q++ D+ IYV++I + GAA DGRLQ GD++L
Sbjct: 188 LETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 247
Query: 68 VNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
VN L+ + H++AV + +N V L+V
Sbjct: 248 VNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
Score = 84.0 bits (206), Expect = 4e-17
Identities = 43/88 (48%), Positives = 57/88 (64%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
EEI L RG SGLGF+I GGTD ++ +D GI++++I GAAA DGRL+ D IL VN
Sbjct: 97 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 156
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRVQHR 99
D+ + H AV+ + AG V L V+ R
Sbjct: 157 DVSEVSHSKAVEALKEAGSIVRLYVRRR 184
Score = 71.2 bits (173), Expect = 3e-13
Identities = 39/87 (44%), Positives = 53/87 (60%), Gaps = 6/87 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
++ L +G +GLGFNIVGG D + GI+VS I G A L G LQ GD+ILSVNG D
Sbjct: 421 KVVLHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELQRGDQILSVNGID 474
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQHR 99
L+ H+ A + AG V++ Q++
Sbjct: 475 LRGASHEQAAAALKGAGQTVTIIAQYQ 501
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 73.6 bits (179), Expect = 6e-14
Identities = 40/87 (45%), Positives = 55/87 (63%), Gaps = 6/87 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
+I L +G +GLGFNIVGG D + GI+VS I G A L G L+ GD+ILSVNG +
Sbjct: 49 KIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVN 102
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQHR 99
L+N H+ A + AG +V++ Q+R
Sbjct: 103 LRNATHEQAAAALKRAGQSVTIVAQYR 129
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 73.6 bits (179), Expect = 6e-14
Identities = 42/80 (52%), Positives = 52/80 (65%), Gaps = 3/80 (3%)
Query: 22 GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81
GLGF+IVGG D Y GIYV I GAAA DGRLQEGD+IL +NG+ + L HQDA
Sbjct: 226 GLGFSIVGGKDSIY--GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283
Query: 82 VDLFRNAGYA-VSLRVQHRL 100
+ F+ A ++L V+ RL
Sbjct: 284 LQKFKQAKKGLLTLTVRTRL 303
Score = 56.6 bits (135), Expect = 7e-09
Identities = 27/68 (39%), Positives = 44/68 (64%), Gaps = 4/68 (5%)
Query: 21 SGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQD 80
+GLGF++ GG D + + I V R+ NG A+ +G +Q+G+++LS+NG+ LK H D
Sbjct: 1122 AGLGFSLAGGADLE----NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
Query: 81 AVDLFRNA 88
A+ + R A
Sbjct: 1178 ALAILRQA 1185
Score = 32.0 bits (71), Expect = 0.19
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVN 69
E++L + +G+G I G Y SGI+V + A LDGRL+ GD+I+ ++
Sbjct: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 73.2 bits (178), Expect = 7e-14
Identities = 38/85 (44%), Positives = 54/85 (63%), Gaps = 2/85 (2%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
+ I L RGP GLGF+IVGG + D IYV + GAA+ DGRL+ GD+I++VNGQ
Sbjct: 1957 KSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2014
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRV 96
L+ + H++AV + + V+L V
Sbjct: 2015 SLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 63.9 bits (154), Expect = 4e-11
Identities = 34/84 (40%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 11 EEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
E I +++G +GLG +IVGG+D I + + E GAA DGRL GD+IL VNG
Sbjct: 1627 ETTIEISKGRTGLGLSIVGGSDTLL----GAIIIHEVYEEGAACKDGRLWAGDQILEVNG 1682
Query: 71 QDLKNLLHQDAVDLFRNAGYAVSL 94
DL+ H +A+++ R V L
Sbjct: 1683 IDLRKATHDEAINVLRQTPQRVRL 1706
Score = 59.7 bits (143), Expect = 8e-10
Identities = 33/98 (33%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
++ LT+ GLG I G + + SGI+V I ++ A DGR+Q GD+I++V+G +
Sbjct: 377 DVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTN 435
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHR 110
L+ +Q AV++ R+ G V L + R Q + R
Sbjct: 436 LQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSR 473
Score = 56.2 bits (134), Expect = 9e-09
Identities = 34/85 (40%), Positives = 50/85 (58%), Gaps = 4/85 (4%)
Query: 12 EEINLTRGPSG-LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
E L + PSG LGF++VG + + GI+V I+E A DGRL+E D+IL++NG
Sbjct: 136 EVFELLKPPSGGLGFSVVGLRSEN--RGELGIFVQEIQEGSVAHRDGRLKETDQILAING 193
Query: 71 QDL-KNLLHQDAVDLFRNAGYAVSL 94
Q L + + HQ A+ + + A V L
Sbjct: 194 QALDQTITHQQAISILQKAKDTVQL 218
Score = 56.2 bits (134), Expect = 9e-09
Identities = 31/81 (38%), Positives = 46/81 (56%), Gaps = 4/81 (4%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
I L +G SGLG ++ G D+ +S +++ I NGAA DGRLQ D++L +NGQ L
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSRMS----VFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 74 KNLLHQDAVDLFRNAGYAVSL 94
HQ+A + + A V +
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKI 1427
Score = 55.8 bits (133), Expect = 1e-08
Identities = 34/89 (38%), Positives = 50/89 (56%), Gaps = 5/89 (5%)
Query: 14 INLTRGPS-GLGFNIVGGTDQ-QYVSNDS---GIYVSRIKENGAAALDGRLQEGDKILSV 68
+ L R PS LG +IVGG +SN GI++ + E+ A +G L+ GD+I+ V
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 69 NGQDLKNLLHQDAVDLFRNAGYAVSLRVQ 97
+G DL++ H+ AV+ R AG V VQ
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240
Score = 55.1 bits (131), Expect = 2e-08
Identities = 31/74 (41%), Positives = 44/74 (59%), Gaps = 7/74 (9%)
Query: 14 INLTRGPS-GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
I L + P GLG +IVG ND+G++VS I + G A DGRL +GD+IL VNG+D
Sbjct: 1726 IELQKKPGKGLGLSIVGKR------NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGED 1779
Query: 73 LKNLLHQDAVDLFR 86
++N + L +
Sbjct: 1780 VRNATQEAVAALLK 1793
Score = 48.1 bits (113), Expect = 3e-06
Identities = 29/85 (34%), Positives = 37/85 (43%), Gaps = 7/85 (8%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
E I L SGLGF I+GG +G+ V I G A GRL GD IL +
Sbjct: 256 ETIELVNDGSGLGFGIIGG-------KATGVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRV 96
DL + + + R G V L +
Sbjct: 309 DLAGMSSEQVAQVLRQCGNRVKLMI 333
Score = 47.0 bits (110), Expect = 6e-06
Identities = 24/84 (28%), Positives = 47/84 (55%), Gaps = 3/84 (3%)
Query: 14 INLTRGPS-GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
+ + +GP+ LG +I GG D I+++ + G AA +L+ GD+I+++ G
Sbjct: 1834 VEMKKGPTDSLGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRV 96
+ + H AV+L +NA ++ ++V
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQV 1915
Score = 42.4 bits (98), Expect = 1e-04
Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
+ I L +G GLGF+I+ D ++ + I + + G A DGRL GD+++ VN
Sbjct: 699 QHIELEKGSKGLGFSILDYQDPIDPAS-TVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757
Query: 72 DLKNLLHQDAVDLFRNA 88
+L+N ++AV+ + A
Sbjct: 758 NLENSSLEEAVEALKGA 774
Score = 39.7 bits (91), Expect = 9e-04
Identities = 24/85 (28%), Positives = 45/85 (52%), Gaps = 6/85 (7%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
+ + L + GLG I +++ +S G+ + + E+G AA DGRL+ GD+IL+V+ +
Sbjct: 1482 QHLELPKDQGGLGIAI---SEEDTLS---GVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRV 96
+ + + L + A V L +
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 38.1 bits (87), Expect = 0.003
Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 6/76 (7%)
Query: 11 EEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
E IN+ +G S LG + D G+ V I GA + DGR+ GD ILS+N
Sbjct: 1006 ERTINIAKGNSSLGMTVSANKD------GLGMIVRSIIHGGAISRDGRIAIGDCILSINE 1059
Query: 71 QDLKNLLHQDAVDLFR 86
+ ++ + A + R
Sbjct: 1060 ESTISVTNAQARAMLR 1075
Score = 33.9 bits (76), Expect = 0.049
Identities = 20/90 (22%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
Query: 5 VDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDK 64
++Y + ++ SGLG ++ ++ + + G G+L GD+
Sbjct: 547 INYEIVVAHVSKFSENSGLGISLEATVGHHFIRS--------VLPEGPVGHSGKLFSGDE 598
Query: 65 ILSVNGQDLKNLLHQDAVDLFRNAGYAVSL 94
+L VNG L HQD V++ + V++
Sbjct: 599 LLEVNGITLLGENHQDVVNILKELPIEVTM 628
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 70.9 bits (172), Expect = 4e-13
Identities = 42/98 (42%), Positives = 57/98 (58%), Gaps = 4/98 (4%)
Query: 9 VTEEEINLT--RGPSGLGFNIVGGTDQQ-YVSNDSGIYVSRIKENGAAALDGRLQEGDKI 65
+ EEE+ LT R GLG +I GG Y +D GI++SR+ E G AA G ++ GDK+
Sbjct: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
Query: 66 LSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQ 103
L VNG L+ H +AV+ R AG AV +RV V+
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVE 818
Score = 67.8 bits (164), Expect = 3e-12
Identities = 37/83 (44%), Positives = 49/83 (59%), Gaps = 1/83 (1%)
Query: 16 LTRGPSGLGFNIVGGTDQQ-YVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLK 74
L R GLGF+I GG Y + D+GI+VSRI E GAA G LQ GD++LS+NG D+
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 75 NLLHQDAVDLFRNAGYAVSLRVQ 97
H AV L A ++L ++
Sbjct: 925 EARHDHAVSLLTAASPTIALLLE 947
Score = 61.6 bits (148), Expect = 2e-10
Identities = 35/89 (39%), Positives = 53/89 (59%), Gaps = 4/89 (4%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQ---YVSNDSGIYVSRIKENGAAALDGRLQEGDKILSV 68
EEI L R LG +IVGG+D + + G+++S++ G AA G L+ GD+IL+V
Sbjct: 1003 EEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAV 1061
Query: 69 NGQDLKNLLHQDAVDLFRNAGYAVSLRVQ 97
NGQD+++ HQ+AV +SL V+
Sbjct: 1062 NGQDVRDATHQEAVSALLRPCLELSLLVR 1090
Score = 53.5 bits (127), Expect = 6e-08
Identities = 31/79 (39%), Positives = 46/79 (58%), Gaps = 6/79 (7%)
Query: 23 LGFNIVGGTDQQYVSN-----DSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLL 77
LG +I GG + + N D GI++S++ GAA DGRL+ G ++L VN Q L L
Sbjct: 1111 LGISIRGGA-RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
Query: 78 HQDAVDLFRNAGYAVSLRV 96
H +AV L R+ G +++ V
Sbjct: 1170 HGEAVQLLRSVGDTLTVLV 1188
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 70.9 bits (172), Expect = 4e-13
Identities = 42/98 (42%), Positives = 57/98 (58%), Gaps = 4/98 (4%)
Query: 9 VTEEEINLT--RGPSGLGFNIVGGTDQQ-YVSNDSGIYVSRIKENGAAALDGRLQEGDKI 65
+ EEE+ LT R GLG +I GG Y +D GI++SR+ E G AA G ++ GDK+
Sbjct: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
Query: 66 LSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQ 103
L VNG L+ H +AV+ R AG AV +RV V+
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVE 818
Score = 67.8 bits (164), Expect = 3e-12
Identities = 37/83 (44%), Positives = 49/83 (59%), Gaps = 1/83 (1%)
Query: 16 LTRGPSGLGFNIVGGTDQQ-YVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLK 74
L R GLGF+I GG Y + D+GI+VSRI E GAA G LQ GD++LS+NG D+
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 75 NLLHQDAVDLFRNAGYAVSLRVQ 97
H AV L A ++L ++
Sbjct: 925 EARHDHAVSLLTAASPTIALLLE 947
Score = 61.6 bits (148), Expect = 2e-10
Identities = 35/89 (39%), Positives = 53/89 (59%), Gaps = 4/89 (4%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQ---YVSNDSGIYVSRIKENGAAALDGRLQEGDKILSV 68
EEI L R LG +IVGG+D + + G+++S++ G AA G L+ GD+IL+V
Sbjct: 1003 EEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAV 1061
Query: 69 NGQDLKNLLHQDAVDLFRNAGYAVSLRVQ 97
NGQD+++ HQ+AV +SL V+
Sbjct: 1062 NGQDVRDATHQEAVSALLRPCLELSLLVR 1090
Score = 53.5 bits (127), Expect = 6e-08
Identities = 31/79 (39%), Positives = 46/79 (58%), Gaps = 6/79 (7%)
Query: 23 LGFNIVGGTDQQYVSN-----DSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLL 77
LG +I GG + + N D GI++S++ GAA DGRL+ G ++L VN Q L L
Sbjct: 1111 LGISIRGGA-RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
Query: 78 HQDAVDLFRNAGYAVSLRV 96
H +AV L R+ G +++ V
Sbjct: 1170 HGEAVQLLRSVGDTLTVLV 1188
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 67.0 bits (162), Expect = 5e-12
Identities = 37/83 (44%), Positives = 49/83 (59%), Gaps = 4/83 (4%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
I +++G SGLG +IVGG D + I + + E GAAA DGRL GD+IL VNG DL
Sbjct: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
Query: 74 KNLLHQDAVDLFRNAGYAVSLRV 96
+N H++A+ R V L V
Sbjct: 1494 RNSSHEEAITALRQTPQKVRLVV 1516
Score = 59.3 bits (142), Expect = 1e-09
Identities = 32/75 (42%), Positives = 46/75 (61%), Gaps = 6/75 (8%)
Query: 22 GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81
GLG +IVG N SG+++S I + GAA LDGRL +GD+ILSVNG+D++N +
Sbjct: 1543 GLGLSIVGKR------NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596
Query: 82 VDLFRNAGYAVSLRV 96
+ + A V L +
Sbjct: 1597 ATILKCAQGLVQLEI 1611
Score = 58.9 bits (141), Expect = 1e-09
Identities = 33/85 (38%), Positives = 44/85 (51%), Gaps = 7/85 (8%)
Query: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
EE+ L SGLGF IVGG SG+ V I G A DGRLQ GD IL + G
Sbjct: 247 EEVELINDGSGLGFGIVGG-------KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
Query: 72 DLKNLLHQDAVDLFRNAGYAVSLRV 96
+++ + + + RN G +V + V
Sbjct: 300 NVQGMTSEQVAQVLRNCGNSVRMLV 324
Score = 55.1 bits (131), Expect = 2e-08
Identities = 29/77 (37%), Positives = 42/77 (54%)
Query: 23 LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAV 82
LG IVG + SGIYV I AA +G +Q DKI++V+G +++ + D V
Sbjct: 376 LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVV 435
Query: 83 DLFRNAGYAVSLRVQHR 99
++ RNAG V L + R
Sbjct: 436 EVLRNAGQVVHLTLVRR 452
Score = 53.9 bits (128), Expect = 5e-08
Identities = 34/89 (38%), Positives = 51/89 (57%), Gaps = 5/89 (5%)
Query: 14 INLTRGPS-GLGFNIVGG-TDQQYVSNDS---GIYVSRIKENGAAALDGRLQEGDKILSV 68
+ + R P+ LG +IVGG T + + N GI++ ++ E+ A L+ GDKIL V
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
Query: 69 NGQDLKNLLHQDAVDLFRNAGYAVSLRVQ 97
+G DL+N H +AV+ +NAG V VQ
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 52.4 bits (124), Expect = 1e-07
Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 23 LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAV 82
LG +I GG D ++++ I+ +G AA +L+ GD+I+S+NGQ L L H D V
Sbjct: 1687 LGISIAGGRGSPL--GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVV 1744
Query: 83 DLFRNAGYAVSLRV 96
+L +NA + L+V
Sbjct: 1745 NLLKNAYGRIILQV 1758
Score = 50.4 bits (119), Expect = 5e-07
Identities = 29/81 (35%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
I L + +GLG ++ G D+ +S I+V I G AA DGR++ GD++L +N Q L
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRMS----IFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 74 KNLLHQDAVDLFRNAGYAVSL 94
HQ+A + + A V L
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKL 1316
Score = 40.0 bits (92), Expect = 7e-04
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 4/87 (4%)
Query: 12 EEINLTR-GPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
E I++ R GLGF++V Q D I+V ++ A D RL+E D+IL++N
Sbjct: 133 EYIDIERPSTGGLGFSVVALRSQNLGKVD--IFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 71 QDL-KNLLHQDAVDLFRNAGYAVSLRV 96
L +N+ HQ A+ L + ++ L V
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIV 217
Score = 33.5 bits (75), Expect = 0.064
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L + GLGF+I+ D + S I + + +G A G L GD+++SVN L
Sbjct: 687 VELVKDCKGLGFSILDYQDPLDPTR-SVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745
Query: 74 KNLLHQDAVDLFR 86
N +AV++ +
Sbjct: 746 DNTSLAEAVEILK 758
Score = 29.6 bits (65), Expect = 0.93
Identities = 17/50 (34%), Positives = 23/50 (46%)
Query: 37 SNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFR 86
S D Y+S I G G LQ D++L VNG L ++AV +
Sbjct: 576 SFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 65.9 bits (159), Expect = 1e-11
Identities = 36/87 (41%), Positives = 51/87 (58%), Gaps = 3/87 (3%)
Query: 16 LTRGPSGLGFNIVGG---TDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
L R LGFNI+GG D S+ GI+VS+I ++G AA +G LQ D+I+ VNG+D
Sbjct: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQHR 99
L H AV+ F+ A + ++V R
Sbjct: 312 LSRATHDQAVEAFKTAKEPIVVQVLRR 338
Score = 51.2 bits (121), Expect = 3e-07
Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 7/75 (9%)
Query: 12 EEINLTRGPSG--LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVN 69
EE++L R S LG + TD + +D GIY+S I N AA DGR++EGD+I+ +N
Sbjct: 418 EEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRIIQIN 474
Query: 70 GQDLKNLLHQDAVDL 84
G +++N ++AV L
Sbjct: 475 GIEVQN--REEAVAL 487
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 64.7 bits (156), Expect = 3e-11
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 2/85 (2%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
E+ L + + LG ++ GG + GIYV + GAA DGR+ +GD++L+VNG
Sbjct: 1177 EVELAKNDNSLGISVTGGVNTSV--RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1234
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQ 97
L+ H+ AV+ RN G V L ++
Sbjct: 1235 LEGATHKQAVETLRNTGQVVHLLLE 1259
Score = 57.0 bits (136), Expect = 5e-09
Identities = 29/73 (39%), Positives = 45/73 (61%), Gaps = 2/73 (2%)
Query: 22 GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81
GLGF I+GG + D GI++S + G A LDG L+ GD+++SVN L+ + H A
Sbjct: 912 GLGFQIIGGEKMGRL--DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAA 969
Query: 82 VDLFRNAGYAVSL 94
+++ +NA V+L
Sbjct: 970 IEILQNAPEDVTL 982
Score = 49.7 bits (117), Expect = 9e-07
Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 8/101 (7%)
Query: 8 LVTEEEINLTRGPSG-LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKIL 66
L E I L + G LGF + G + G YV + ++ A + DGRL+ GD+++
Sbjct: 1592 LEVELLITLIKSEKGSLGFTVTKGNQR------IGCYVHDVIQDPAKS-DGRLKPGDRLI 1644
Query: 67 SVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPI 107
VN D+ N+ H DAV+L R A V L + L++ P+
Sbjct: 1645 KVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPM 1685
Score = 38.1 bits (87), Expect = 0.003
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 4/58 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
+I LT LGF++ GG D Y +Y+S I AA++G LQ D I VNG
Sbjct: 1692 DITLTCNKEELGFSLCGGHDSLY----QVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1745
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 64.7 bits (156), Expect = 3e-11
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 2/85 (2%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
E+ L + + LG ++ GG + GIYV + GAA DGR+ +GD++L+VNG
Sbjct: 1368 EVELAKNDNSLGISVTGGVNTSV--RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1425
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQ 97
L+ H+ AV+ RN G V L ++
Sbjct: 1426 LEGATHKQAVETLRNTGQVVHLLLE 1450
Score = 57.0 bits (136), Expect = 5e-09
Identities = 29/73 (39%), Positives = 45/73 (61%), Gaps = 2/73 (2%)
Query: 22 GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81
GLGF I+GG + D GI++S + G A LDG L+ GD+++SVN L+ + H A
Sbjct: 1103 GLGFQIIGGEKMGRL--DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAA 1160
Query: 82 VDLFRNAGYAVSL 94
+++ +NA V+L
Sbjct: 1161 IEILQNAPEDVTL 1173
Score = 49.7 bits (117), Expect = 9e-07
Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 8/101 (7%)
Query: 8 LVTEEEINLTRGPSG-LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKIL 66
L E I L + G LGF + G + G YV + ++ A + DGRL+ GD+++
Sbjct: 1783 LEVELLITLIKSEKGSLGFTVTKGNQR------IGCYVHDVIQDPAKS-DGRLKPGDRLI 1835
Query: 67 SVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPI 107
VN D+ N+ H DAV+L R A V L + L++ P+
Sbjct: 1836 KVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPM 1876
Score = 38.1 bits (87), Expect = 0.003
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 4/58 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
+I LT LGF++ GG D Y +Y+S I AA++G LQ D I VNG
Sbjct: 1883 DITLTCNKEELGFSLCGGHDSLY----QVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1936
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 64.7 bits (156), Expect = 3e-11
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 2/85 (2%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
E+ L + + LG ++ GG + GIYV + GAA DGR+ +GD++L+VNG
Sbjct: 1349 EVELAKNDNSLGISVTGGVNTSV--RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1406
Query: 73 LKNLLHQDAVDLFRNAGYAVSLRVQ 97
L+ H+ AV+ RN G V L ++
Sbjct: 1407 LEGATHKQAVETLRNTGQVVHLLLE 1431
Score = 57.0 bits (136), Expect = 5e-09
Identities = 29/73 (39%), Positives = 45/73 (61%), Gaps = 2/73 (2%)
Query: 22 GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81
GLGF I+GG + D GI++S + G A LDG L+ GD+++SVN L+ + H A
Sbjct: 1084 GLGFQIIGGEKMGRL--DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAA 1141
Query: 82 VDLFRNAGYAVSL 94
+++ +NA V+L
Sbjct: 1142 IEILQNAPEDVTL 1154
Score = 49.7 bits (117), Expect = 9e-07
Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 8/101 (7%)
Query: 8 LVTEEEINLTRGPSG-LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKIL 66
L E I L + G LGF + G + G YV + ++ A + DGRL+ GD+++
Sbjct: 1764 LEVELLITLIKSEKGSLGFTVTKGNQR------IGCYVHDVIQDPAKS-DGRLKPGDRLI 1816
Query: 67 SVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPI 107
VN D+ N+ H DAV+L R A V L + L++ P+
Sbjct: 1817 KVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPM 1857
Score = 38.1 bits (87), Expect = 0.003
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 4/58 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
+I LT LGF++ GG D Y +Y+S I AA++G LQ D I VNG
Sbjct: 1864 DITLTCNKEELGFSLCGGHDSLY----QVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1917
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 64.7 bits (156), Expect = 3e-11
Identities = 37/113 (32%), Positives = 61/113 (53%), Gaps = 9/113 (7%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L RG G GF++ GG + + +YV R+ E+G A G+++ GD+IL +NG+
Sbjct: 1153 VELERGAKGFGFSLRGGREY-----NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1207
Query: 74 KNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPIFMVLVP 126
KN+ H A++L +N G RV+ L+ +G + G + IP F + P
Sbjct: 1208 KNMKHSRAIELIKNGG----RRVRLFLKRGDGSVPEYGGSNYENIPSFPGMTP 1256
Score = 50.1 bits (118), Expect = 7e-07
Identities = 29/78 (37%), Positives = 42/78 (53%), Gaps = 5/78 (6%)
Query: 11 EEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
E++I L R +G GF I+GG + IY+ I GAA DGRL+ GD+++ V+G
Sbjct: 839 EQDIFLWRKETGFGFRILGGNEP-----GEPIYIGHIVPLGAADTDGRLRSGDELICVDG 893
Query: 71 QDLKNLLHQDAVDLFRNA 88
+ HQ V L + A
Sbjct: 894 TPVIGKSHQLVVQLMQQA 911
Score = 48.9 bits (115), Expect = 1e-06
Identities = 33/104 (31%), Positives = 50/104 (48%), Gaps = 9/104 (8%)
Query: 2 NGRVDYLVTEEEINLTRGPS-GLGFNIVGGTDQQYVSNDSG--------IYVSRIKENGA 52
+G V +V ++ + RG + G GF IV + + RI E
Sbjct: 987 SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSP 1046
Query: 53 AALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
A G+L+ GD+IL+VNG + N H D V+L + AG V+LR+
Sbjct: 1047 ADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1090
Score = 44.3 bits (103), Expect = 4e-05
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 16 LTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKN 75
L + G GF +VGG + D + + + +G AALDG+++ GD I+SVN +
Sbjct: 475 LRKSSRGFGFTVVGGDEP-----DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 76 LLHQDAVDLFRNAGYAVSLRVQ 97
H V +F++ S+ ++
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLE 551
Score = 34.7 bits (78), Expect = 0.029
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 17/89 (19%)
Query: 14 INLTRGPSGLGFNIV---GGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
+++ +GP G GF I GG Q R+K+ + L+EGD I+ VN
Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQ------------RVKQIVDSPRCRGLKEGDLIVEVNK 691
Query: 71 QDLKNLLHQDAVDLFRNA--GYAVSLRVQ 97
++++ L H VD+ G V+L VQ
Sbjct: 692 KNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 63.5 bits (153), Expect = 6e-11
Identities = 33/65 (50%), Positives = 43/65 (66%), Gaps = 2/65 (3%)
Query: 22 GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81
GLGF+I GG D + GI+V I NG+AA DGRL+EGD+IL VNG +K L Q+A
Sbjct: 596 GLGFSIAGGRD--CIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEA 653
Query: 82 VDLFR 86
+ F+
Sbjct: 654 IHTFK 658
Score = 55.8 bits (133), Expect = 1e-08
Identities = 36/96 (37%), Positives = 52/96 (54%), Gaps = 7/96 (7%)
Query: 6 DYLVTEE-----EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQ 60
D L EE ++ L + GLG + GG + + I V+++KE GAA DGRL
Sbjct: 322 DCLAREEVGRIWKMELLKESDGLGIQVSGGRGSK--RSPHAIVVTQVKEGGAAHRDGRLS 379
Query: 61 EGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
GD++L +NG L L H++AV + R+A V L V
Sbjct: 380 LGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVV 415
Score = 51.2 bits (121), Expect = 3e-07
Identities = 28/68 (41%), Positives = 39/68 (57%), Gaps = 4/68 (5%)
Query: 21 SGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQD 80
SGLGF++ GGTD + S I V R+ GAA+ +G + GD +LSVNG L L H +
Sbjct: 2631 SGLGFSVAGGTDVEPKS----ITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
Query: 81 AVDLFRNA 88
+ + A
Sbjct: 2687 VLKVLHQA 2694
Score = 48.9 bits (115), Expect = 1e-06
Identities = 23/74 (31%), Positives = 45/74 (60%), Gaps = 2/74 (2%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ + + +GLG ++ GG V+ D + + R+ + GAA G ++ GD+IL++NG+ L
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSS--VTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
Query: 74 KNLLHQDAVDLFRN 87
L+H DA ++ ++
Sbjct: 2809 VGLMHFDAWNIMKS 2822
Score = 31.6 bits (70), Expect = 0.25
Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 13 EINLTRGPS-GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
E+ L + P GLG +G ++ GIY+ + A ++ L GD+IL VN
Sbjct: 728 EVTLNKEPRVGLG---IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSV 784
Query: 72 DLKN 75
++++
Sbjct: 785 NVRH 788
Score = 30.0 bits (66), Expect = 0.71
Identities = 15/41 (36%), Positives = 26/41 (63%)
Query: 31 TDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
T Q V + I+V+ +++N A G+++ D+ILS+NGQ
Sbjct: 108 THQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQ 148
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 62.0 bits (149), Expect = 2e-10
Identities = 35/89 (39%), Positives = 54/89 (60%), Gaps = 5/89 (5%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L + GLGFN++GG +Q +S IY+SRI G A G L+ GD++LSVNG +
Sbjct: 109 VELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
Query: 74 KNLLHQDAVDLFRNAGYAVSLRVQHRLQV 102
+ H+ AV+L + A +V L V++ +V
Sbjct: 164 EGEHHEKAVELLKAAKDSVKLVVRYTPKV 192
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 62.0 bits (149), Expect = 2e-10
Identities = 35/89 (39%), Positives = 54/89 (60%), Gaps = 5/89 (5%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L + GLGFNI+GG +Q +S IY+SR+ G A G L+ GD++LSVNG +
Sbjct: 94 VELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
Query: 74 KNLLHQDAVDLFRNAGYAVSLRVQHRLQV 102
+ H+ AV+L + A +V L V++ +V
Sbjct: 149 EGEQHEKAVELLKAAQGSVKLVVRYTPRV 177
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 62.0 bits (149), Expect = 2e-10
Identities = 37/119 (31%), Positives = 62/119 (52%), Gaps = 20/119 (16%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L RG G GF++ GG + + +YV R+ E+G A G+++ GD+IL +NG+
Sbjct: 1152 VELERGAKGFGFSLRGGREY-----NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1206
Query: 74 KNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPIFMVLVPVFALTM 132
KN+ H A++L +N G V L ++ RG+G +P + ++ P A M
Sbjct: 1207 KNMKHSRAIELIKNGGRRVRLFLK------------RGDG---SVPEYAMIPPNIAACM 1250
Score = 51.6 bits (122), Expect = 2e-07
Identities = 34/103 (33%), Positives = 51/103 (49%), Gaps = 8/103 (7%)
Query: 2 NGRVDYLVTEEEINLTRGPS-GLGFNIVGGTDQQYVSNDSGIY-------VSRIKENGAA 53
+G V +V ++ + RG + G GF IV + G + RI E A
Sbjct: 987 SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPA 1046
Query: 54 ALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
G+L+ GD+IL+VNG + N H D V+L + AG V+LR+
Sbjct: 1047 DRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089
Score = 50.1 bits (118), Expect = 7e-07
Identities = 29/78 (37%), Positives = 42/78 (53%), Gaps = 5/78 (6%)
Query: 11 EEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
E++I L R +G GF I+GG + IY+ I GAA DGRL+ GD+++ V+G
Sbjct: 839 EQDIFLWRKETGFGFRILGGNEP-----GEPIYIGHIVPLGAADTDGRLRSGDELICVDG 893
Query: 71 QDLKNLLHQDAVDLFRNA 88
+ HQ V L + A
Sbjct: 894 TPVIGKSHQLVVQLMQQA 911
Score = 44.3 bits (103), Expect = 4e-05
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 16 LTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKN 75
L + G GF +VGG + D + + + +G AALDG+++ GD I+SVN +
Sbjct: 475 LRKSSRGFGFTVVGGDEP-----DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 76 LLHQDAVDLFRNAGYAVSLRVQ 97
H V +F++ S+ ++
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLE 551
Score = 34.7 bits (78), Expect = 0.029
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 17/89 (19%)
Query: 14 INLTRGPSGLGFNIV---GGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
+++ +GP G GF I GG Q R+K+ + L+EGD I+ VN
Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQ------------RVKQIVDSPRCRGLKEGDLIVEVNK 691
Query: 71 QDLKNLLHQDAVDLFRNA--GYAVSLRVQ 97
++++ L H VD+ G V+L VQ
Sbjct: 692 KNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 61.2 bits (147), Expect = 3e-10
Identities = 30/81 (37%), Positives = 48/81 (59%), Gaps = 5/81 (6%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L RG G GF++ GG + + +YV R+ E+G A G+++ GD+IL +NG+
Sbjct: 1124 VELERGAKGFGFSLRGGREY-----NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1178
Query: 74 KNLLHQDAVDLFRNAGYAVSL 94
KN+ H A++L +N G V L
Sbjct: 1179 KNMKHSRAIELIKNGGRRVRL 1199
Score = 51.6 bits (122), Expect = 2e-07
Identities = 34/103 (33%), Positives = 51/103 (49%), Gaps = 8/103 (7%)
Query: 2 NGRVDYLVTEEEINLTRGPS-GLGFNIVGGTDQQYVSNDSGIY-------VSRIKENGAA 53
+G V +V ++ + RG + G GF IV + G + RI E A
Sbjct: 959 SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPA 1018
Query: 54 ALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
G+L+ GD+IL+VNG + N H D V+L + AG V+LR+
Sbjct: 1019 DRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061
Score = 50.1 bits (118), Expect = 7e-07
Identities = 29/78 (37%), Positives = 42/78 (53%), Gaps = 5/78 (6%)
Query: 11 EEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
E++I L R +G GF I+GG + IY+ I GAA DGRL+ GD+++ V+G
Sbjct: 811 EQDIFLWRKETGFGFRILGGNEP-----GEPIYIGHIVPLGAADTDGRLRSGDELICVDG 865
Query: 71 QDLKNLLHQDAVDLFRNA 88
+ HQ V L + A
Sbjct: 866 TPVIGKSHQLVVQLMQQA 883
Score = 44.3 bits (103), Expect = 4e-05
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 16 LTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKN 75
L + G GF +VGG + D + + + +G AALDG+++ GD I+SVN +
Sbjct: 475 LRKSSRGFGFTVVGGDEP-----DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 76 LLHQDAVDLFRNAGYAVSLRVQ 97
H V +F++ S+ ++
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLE 551
Score = 34.7 bits (78), Expect = 0.029
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 17/89 (19%)
Query: 14 INLTRGPSGLGFNIV---GGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
+++ +GP G GF I GG Q R+K+ + L+EGD I+ VN
Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQ------------RVKQIVDSPRCRGLKEGDLIVEVNK 691
Query: 71 QDLKNLLHQDAVDLFRNA--GYAVSLRVQ 97
++++ L H VD+ G V+L VQ
Sbjct: 692 KNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 60.8 bits (146), Expect = 4e-10
Identities = 36/89 (40%), Positives = 53/89 (59%), Gaps = 5/89 (5%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L + GLGFNI+GG +Q +S IY+SRI G A G L+ GD++LSVNG +
Sbjct: 94 VELPKTEEGLGFNIMGGKEQ-----NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148
Query: 74 KNLLHQDAVDLFRNAGYAVSLRVQHRLQV 102
+ H+ AV+L + A V L V++ +V
Sbjct: 149 EGEHHEKAVELLKAAQGKVKLVVRYTPKV 177
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 60.5 bits (145), Expect = 5e-10
Identities = 28/81 (34%), Positives = 48/81 (59%), Gaps = 5/81 (6%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L RGP G GF++ GG + + G+++ R+ E+G A DGR+ GD+I+ +NG+
Sbjct: 1022 VELERGPRGFGFSLRGGKEY-----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
Query: 74 KNLLHQDAVDLFRNAGYAVSL 94
+ + H A++L + G V L
Sbjct: 1077 QGITHTRAIELIQAGGNKVLL 1097
Score = 47.8 bits (112), Expect = 3e-06
Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 5/76 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
++ L + SG GF ++GG D IY+ I GAA DGRL+ D+++ ++G
Sbjct: 726 DVFLRKQESGFGFRVLGGDGP-----DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
Query: 73 LKNLLHQDAVDLFRNA 88
+K H+ +DL A
Sbjct: 781 VKGKSHKQVLDLMTTA 796
Score = 45.1 bits (105), Expect = 2e-05
Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 15 NLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLK 74
+L + G GF I+GG D + V + ++G AA DG++ GD I+ +NG +
Sbjct: 412 SLKKSTMGFGFTIIGGDRP-----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVL 466
Query: 75 NLLHQDAVDLFR 86
H D V +F+
Sbjct: 467 GHTHADVVQMFQ 478
Score = 42.0 bits (97), Expect = 2e-04
Identities = 21/53 (39%), Positives = 31/53 (58%)
Query: 44 VSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
+ R+ E A G+L+ GD I +VNGQ + L H + V L ++AG V+L V
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTV 934
Score = 28.5 bits (62), Expect = 2.1
Identities = 22/77 (28%), Positives = 32/77 (41%), Gaps = 19/77 (24%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGR----LQEGDKILSVN 69
I L +GP G GF I Q V LD + LQ+GD I +
Sbjct: 579 IPLIKGPKGFGFAIADSPTGQKVK---------------MILDSQWCQGLQKGDIIKEIY 623
Query: 70 GQDLKNLLHQDAVDLFR 86
Q+++NL H V++ +
Sbjct: 624 HQNVQNLTHLQVVEVLK 640
Score = 28.1 bits (61), Expect = 2.7
Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 23/120 (19%)
Query: 9 VTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAA----LDGRLQE-GD 63
V E ++ P G I GG ++ Y+ R++E + G+ GD
Sbjct: 15 VQECAVSWAGPPGDFGAEIRGGAERGEFP-----YLGRLREEPGGGTCCVVSGKAPSPGD 69
Query: 64 KILSVNGQDLKNLLHQDAVDLFRN-----------AGYAVSLRVQH--RLQVQNGPIGHR 110
+L VNG + L ++D + + R+ G ++ ++H LQ Q G I H+
Sbjct: 70 VLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHK 129
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 60.5 bits (145), Expect = 5e-10
Identities = 28/81 (34%), Positives = 48/81 (59%), Gaps = 5/81 (6%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
+ L RGP G GF++ GG + + G+++ R+ E+G A DGR+ GD+I+ +NG+
Sbjct: 1022 VELERGPRGFGFSLRGGKEY-----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
Query: 74 KNLLHQDAVDLFRNAGYAVSL 94
+ + H A++L + G V L
Sbjct: 1077 QGITHTRAIELIQAGGNKVLL 1097
Score = 47.8 bits (112), Expect = 3e-06
Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 5/76 (6%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
++ L + SG GF ++GG D IY+ I GAA DGRL+ D+++ ++G
Sbjct: 726 DVFLRKQESGFGFRVLGGDGP-----DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
Query: 73 LKNLLHQDAVDLFRNA 88
+K H+ +DL A
Sbjct: 781 VKGKSHKQVLDLMTTA 796
Score = 45.1 bits (105), Expect = 2e-05
Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 15 NLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLK 74
+L + G GF I+GG D + V + ++G AA DG++ GD I+ +NG +
Sbjct: 412 SLKKSTMGFGFTIIGGDRP-----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVL 466
Query: 75 NLLHQDAVDLFR 86
H D V +F+
Sbjct: 467 GHTHADVVQMFQ 478
Score = 42.0 bits (97), Expect = 2e-04
Identities = 21/53 (39%), Positives = 31/53 (58%)
Query: 44 VSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRV 96
+ R+ E A G+L+ GD I +VNGQ + L H + V L ++AG V+L V
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTV 934
Score = 28.5 bits (62), Expect = 2.1
Identities = 22/77 (28%), Positives = 32/77 (41%), Gaps = 19/77 (24%)
Query: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGR----LQEGDKILSVN 69
I L +GP G GF I Q V LD + LQ+GD I +
Sbjct: 579 IPLIKGPKGFGFAIADSPTGQKVK---------------MILDSQWCQGLQKGDIIKEIY 623
Query: 70 GQDLKNLLHQDAVDLFR 86
Q+++NL H V++ +
Sbjct: 624 HQNVQNLTHLQVVEVLK 640
Score = 28.1 bits (61), Expect = 2.7
Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 23/120 (19%)
Query: 9 VTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAA----LDGRLQE-GD 63
V E ++ P G I GG ++ Y+ R++E + G+ GD
Sbjct: 15 VQECAVSWAGPPGDFGAEIRGGAERGEFP-----YLGRLREEPGGGTCCVVSGKAPSPGD 69
Query: 64 KILSVNGQDLKNLLHQDAVDLFRN-----------AGYAVSLRVQH--RLQVQNGPIGHR 110
+L VNG + L ++D + + R+ G ++ ++H LQ Q G I H+
Sbjct: 70 VLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHK 129
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 60.1 bits (144), Expect = 6e-10
Identities = 31/75 (41%), Positives = 44/75 (58%), Gaps = 2/75 (2%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
+I+L +GP GLGF +V T + I+V I GAA DGRLQ GD+IL VNG+D
Sbjct: 383 KIDLKKGPEGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
Query: 73 LKNLLHQDAVDLFRN 87
+ ++ V + R+
Sbjct: 441 VTGRTQEELVAMLRS 455
Score = 47.4 bits (111), Expect = 4e-06
Identities = 23/70 (32%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Query: 19 GPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLH 78
G +GLG ++ G ++ D GI++ I GAA DGRL+ D++++VNG+ L +
Sbjct: 505 GSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563
Query: 79 QDAVDLFRNA 88
+A++ R +
Sbjct: 564 HEAMETLRRS 573
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 60.1 bits (144), Expect = 6e-10
Identities = 31/75 (41%), Positives = 44/75 (58%), Gaps = 2/75 (2%)
Query: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQD 72
+I+L +GP GLGF +V T + I+V I GAA DGRLQ GD+IL VNG+D
Sbjct: 383 KIDLKKGPEGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
Query: 73 LKNLLHQDAVDLFRN 87
+ ++ V + R+
Sbjct: 441 VTGRTQEELVAMLRS 455
Score = 47.4 bits (111), Expect = 4e-06
Identities = 23/70 (32%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Query: 19 GPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLH 78
G +GLG ++ G ++ D GI++ I GAA DGRL+ D++++VNG+ L +
Sbjct: 505 GSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563
Query: 79 QDAVDLFRNA 88
+A++ R +
Sbjct: 564 HEAMETLRRS 573
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,437,634
Number of Sequences: 37866
Number of extensions: 221907
Number of successful extensions: 1095
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 688
Number of HSP's gapped (non-prelim): 342
length of query: 145
length of database: 18,247,518
effective HSP length: 92
effective length of query: 53
effective length of database: 14,763,846
effective search space: 782483838
effective search space used: 782483838
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 57 (26.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.