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Search of human proteins with 153945755
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153945755 zinc finger protein 608 [Homo sapiens]
(1512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153945755 zinc finger protein 608 [Homo sapiens] 3043 0.0
gi|71725360 zinc finger protein 609 [Homo sapiens] 1004 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 63 2e-09
gi|57864582 hornerin [Homo sapiens] 62 3e-09
gi|28559039 mediator complex subunit 1 [Homo sapiens] 58 6e-08
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 56 3e-07
gi|4504733 insulin receptor substrate 4 [Homo sapiens] 55 7e-07
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 54 9e-07
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 54 9e-07
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 52 4e-06
gi|62122917 filaggrin family member 2 [Homo sapiens] 51 1e-05
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 50 2e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 50 2e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 49 3e-05
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 49 4e-05
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 49 5e-05
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 48 8e-05
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 48 8e-05
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 48 8e-05
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 47 1e-04
gi|71274144 AT hook, DNA binding motif, containing 1 [Homo sapiens] 47 1e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 47 1e-04
gi|150456424 RW1 protein [Homo sapiens] 46 2e-04
gi|7657218 bromodomain-containing protein 4 isoform short [Homo ... 46 3e-04
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 46 3e-04
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 45 4e-04
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 45 5e-04
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 45 5e-04
gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo s... 45 7e-04
gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo s... 45 7e-04
>gi|153945755 zinc finger protein 608 [Homo sapiens]
Length = 1512
Score = 3043 bits (7888), Expect = 0.0
Identities = 1512/1512 (100%), Positives = 1512/1512 (100%)
Query: 1 MSVNISTAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSS 60
MSVNISTAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSS
Sbjct: 1 MSVNISTAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSS 60
Query: 61 NSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLP 120
NSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLP
Sbjct: 61 NSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLP 120
Query: 121 SAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAG 180
SAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAG
Sbjct: 121 SAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAG 180
Query: 181 AGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGA 240
AGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGA
Sbjct: 181 AGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGA 240
Query: 241 KSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKT 300
KSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKT
Sbjct: 241 KSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKT 300
Query: 301 EKVDPLFTVPAPPPPISSSLTPQILPSYFSPSSSNIAAPVEQLLVRTRSVGVNTCEVGVV 360
EKVDPLFTVPAPPPPISSSLTPQILPSYFSPSSSNIAAPVEQLLVRTRSVGVNTCEVGVV
Sbjct: 301 EKVDPLFTVPAPPPPISSSLTPQILPSYFSPSSSNIAAPVEQLLVRTRSVGVNTCEVGVV 360
Query: 361 TEPECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCE 420
TEPECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCE
Sbjct: 361 TEPECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCE 420
Query: 421 SPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRR 480
SPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRR
Sbjct: 421 SPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRR 480
Query: 481 TPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPET 540
TPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPET
Sbjct: 481 TPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPET 540
Query: 541 TFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEE 600
TFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEE
Sbjct: 541 TFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEE 600
Query: 601 GLSNVALECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNS 660
GLSNVALECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNS
Sbjct: 601 GLSNVALECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNS 660
Query: 661 GKKKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKA 720
GKKKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKA
Sbjct: 661 GKKKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKA 720
Query: 721 TNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATP 780
TNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATP
Sbjct: 721 TNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATP 780
Query: 781 KSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLE 840
KSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLE
Sbjct: 781 KSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLE 840
Query: 841 DSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGS 900
DSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGS
Sbjct: 841 DSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGS 900
Query: 901 ASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRS 960
ASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRS
Sbjct: 901 ASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRS 960
Query: 961 KASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAG 1020
KASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAG
Sbjct: 961 KASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAG 1020
Query: 1021 NSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSVITQRHPALAQSLYY 1080
NSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSVITQRHPALAQSLYY
Sbjct: 1021 NSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSVITQRHPALAQSLYY 1080
Query: 1081 GQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGK 1140
GQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGK
Sbjct: 1081 GQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGK 1140
Query: 1141 EETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKA 1200
EETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKA
Sbjct: 1141 EETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKA 1200
Query: 1201 KQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEEL 1260
KQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEEL
Sbjct: 1201 KQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEEL 1260
Query: 1261 DREKKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPV 1320
DREKKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPV
Sbjct: 1261 DREKKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPV 1320
Query: 1321 NWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLSP 1380
NWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLSP
Sbjct: 1321 NWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLSP 1380
Query: 1381 GFHYPVYGKMSGREETEKVNTSPSVNTKTTTESKALDLLQQHANQYRSKSPAPVEKATAE 1440
GFHYPVYGKMSGREETEKVNTSPSVNTKTTTESKALDLLQQHANQYRSKSPAPVEKATAE
Sbjct: 1381 GFHYPVYGKMSGREETEKVNTSPSVNTKTTTESKALDLLQQHANQYRSKSPAPVEKATAE 1440
Query: 1441 REREAERERDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQA 1500
REREAERERDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQA
Sbjct: 1441 REREAERERDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQA 1500
Query: 1501 SASGMFPGQRRE 1512
SASGMFPGQRRE
Sbjct: 1501 SASGMFPGQRRE 1512
>gi|71725360 zinc finger protein 609 [Homo sapiens]
Length = 1411
Score = 1004 bits (2596), Expect = 0.0
Identities = 670/1572 (42%), Positives = 897/1572 (57%), Gaps = 233/1572 (14%)
Query: 6 STAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDC 65
++ GKGVD N V+TYDSGD+W+IGVGNLIIDLDADLEKD+QK EM S SK+
Sbjct: 7 ASGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEM---------SGSKEV 57
Query: 66 GGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALY 125
G PA + A A L D +KF + PQG KSK KRSK+ KD +K P +L+
Sbjct: 58 GIPAPN---AVATLPDNIKFVT-PVPGPQGKE----GKSKSKRSKSGKDTSKPTPGTSLF 109
Query: 126 GIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCG 185
E ++EVQGR G+ + G S AA A G
Sbjct: 110 TPSE--GAASKKEVQGRSGDGANAGGLVAAIAPKG------------SEKAAKASRSVAG 155
Query: 186 KSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGG 245
KE++ S+S + +R + G + +LQ P GG G + +G
Sbjct: 156 SKKEKENSSSKSKK--ERSEGVGTCSEKDPGVLQ--------PVPLGGR----GGQYDGS 201
Query: 246 GASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESH-RRIKKLKTEKVD 304
G +G+V G + A + G N + K E EE E+ R +KK+K+EK++
Sbjct: 202 A-------GVDTGAVEPLGSI---AIEPGAALNPLGTKPEPEEGENECRLLKKVKSEKME 251
Query: 305 PLFTVPAPPPPISSSLTPQILPSYFSPS--SSNIAAPVEQLLVRTRSVGVNTCEVGVVTE 362
P+S TP +LP + +++I++P EQ++VRTRSVGVNTC+V + TE
Sbjct: 252 S---------PVS---TPAVLPIHLLVPVVNNDISSPCEQIMVRTRSVGVNTCDVALATE 299
Query: 363 PECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCESP 422
PECLGPCEPGTSVNLEGIVW ETE+G+LVVNVTWRNKTYVGTLLDCT+HDWAPPRFC+SP
Sbjct: 300 PECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGTLLDCTRHDWAPPRFCDSP 359
Query: 423 TSDLEMRGGRGRGKRARSAAAAPGSE-ASFTESRGLQN--KNRGGANGKGRRGSLNASGR 479
TSDLEMR GRGRGKR R + P +E A+ ++S+G N K R GAN KGRRGS N+S
Sbjct: 360 TSDLEMRNGRGRGKRMRPNSNTPVNETATASDSKGTSNSSKTRAGANSKGRRGSQNSSEH 419
Query: 480 RTPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPT--TPQGK 537
R P + +ED+KASPSS NKRKNKP +++LNSSSED+K KRVRTNS + T P K
Sbjct: 420 RPPASSTSEDVKASPSSANKRKNKPLSDMELNSSSEDSKGSKRVRTNSMGSATGPLPGTK 479
Query: 538 PETTFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSE---DK 594
E T LD+ C SPVLIDCPHPNCNKKYKHINGL+YHQAHAH D ++K E + DSE +
Sbjct: 480 VEPTVLDRNCPSPVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEEP 539
Query: 595 ISDCEEGLSNVALECSE----PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGS 650
I + G N A + P+ S + +L P SP + T ++ +S +
Sbjct: 540 ILHADLGSCNGASVSQKGSLSPARSATPKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDT 599
Query: 651 IIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKN 710
+GA + S + +E +N A DS +++K
Sbjct: 600 DLGALSNDGSDDGPSVMDETSN--------DAFDS--------------------LERKC 631
Query: 711 LGDKEKGKKATNCKTDKNLSK-LKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLP 769
+ +KEK KK ++ K +K SK LKSARPIAPA P Q+ TATFT + G+ GL
Sbjct: 632 M-EKEKCKKPSSLKPEKIPSKSLKSARPIAPAIPPQ--QIYTFQTATFTAASPGSSSGL- 687
Query: 770 SLTTTVVQATPKSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGS 829
T TV QA P SP LKPIQPKPT+MGEP TVNPAL KDKKKK+K+K + KE S
Sbjct: 688 --TATVAQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKK--KESSKELES 743
Query: 830 PKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTF 889
P K+ + E+ K ++ G +K EGL NG S+ +SR+ASIKAEADK+Y+F
Sbjct: 744 PLTPGKVCRAEEGKSPFRESSGDGMK-----MEGLLNGSSDPHQSRLASIKAEADKIYSF 798
Query: 890 TDNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDG 949
TDNAPSPSIG +SRLE +T P+ PLHV+TQNGAE+S+ KT+SPAYSDISDA +DG
Sbjct: 799 TDNAPSPSIGGSSRLENTTPTQ---PLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDG 855
Query: 950 GSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYM 1009
+ + + ++SK + + +VK + T Q + SPYY ++ YYSPSY
Sbjct: 856 --EGKVDSVKSKDA---------EQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPSYA 904
Query: 1010 H--PGQVGAPAAGNSGSTQGMKIKKESE-EDAEKKDKAEQLDSKKVDHNSASLQPQHQSV 1066
PG + P++ +Q +K K++ E E E K K + + KK + +S+S QP SV
Sbjct: 905 QSSPGALN-PSSQAGVESQALKTKRDEEPESIEGKVKNDICEEKKPELSSSSQQP---SV 960
Query: 1067 ITQRHPALAQSLYYGQYAYGL---YMDQK---SLMATSPAYRQQYEKYYEDQRLAEQKMA 1120
I QR QSLYY QYAY Y DQ L++T+ AYRQQYE+ + Q L +Q+
Sbjct: 961 IQQRPNMYMQSLYYNQYAYVPPYGYSDQSYHTHLLSTNTAYRQQYEEQQKRQSLEQQQ-- 1018
Query: 1121 QTGRGDCERKSELPLKELG---KEETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKT 1177
RG ++K+E+ LKE KEE KQK T++KAPS + L S P K
Sbjct: 1019 ---RG-VDKKAEMGLKEREAALKEEWKQKPSIPPTLTKAPSLTD-------LVKSGPGKA 1067
Query: 1178 EETG----KSQLL-----SNHQQQLQADSFKAKQMENHQLIKEAVEMKSVMDSMKQTGVD 1228
+E G KS ++ S+ + K K + L KEA E K+ + +Q +D
Sbjct: 1068 KEPGADPAKSVIIPKLDDSSKLPGQAPEGLKVKLSDASHLSKEASEAKTGAECGRQAEMD 1127
Query: 1229 PTSRFKQDPDSRTWHHYVYQPKYLDQQKSEEL---DREKKLKEDSPRKTPNKESGVPSLP 1285
P ++Q+ + R W YVY KY D + +E +R++KLKE+ R + VP
Sbjct: 1128 PILWYRQEAEPRMWT-YVYPAKYSDIKSEDERWKEERDRKLKEERSRS----KDSVP--- 1179
Query: 1286 VSLTSIKEEPKEAKHPDSQ--SMEESKLKNDDRKTPVNWKDSRGTRVAVSSPMSQHQSYI 1343
KE+ KE+ D + + EES+L + + + V+ V VSSP++QHQSYI
Sbjct: 1180 ------KEDGKESTSSDCKLPTSEESRLGSKEPRPSVH--------VPVSSPLTQHQSYI 1225
Query: 1344 QYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLSPGFHYPVYG-KMSGREETEKVNTS 1402
Y+H Y Y Q YDP+HP+YR++ V+M +YPG+YL + + YG K+SG E+ +K S
Sbjct: 1226 PYMHGYSYSQSYDPNHPSYRSMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARAS 1285
Query: 1403 PSVNTKTTTESKALDLLQQHANQYRSKSPAPVEKATAERER------------------- 1443
PSV K+++ESKALD+LQQHA+ Y+SKSP +K + ER+R
Sbjct: 1286 PSVTCKSSSESKALDILQQHASHYKSKSPTISDKTSQERDRGGCGVVGGGGSCSSVGGAS 1345
Query: 1444 --EAERERDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYD-PF-QGLTSAALVASQQVAAQ 1499
E +R R SP QR + THHH H +GY L+P QY+ P+ GL+S A+VASQ Q
Sbjct: 1346 GGERSVDRPRTSP-SQRLMSTHHHHH-HLGYSLLPAQYNLPYAAGLSSTAIVASQ----Q 1399
Query: 1500 ASASGMFPGQRR 1511
S ++P RR
Sbjct: 1400 GSTPSLYPPPRR 1411
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 62.8 bits (151), Expect = 2e-09
Identities = 125/617 (20%), Positives = 251/617 (40%), Gaps = 77/617 (12%)
Query: 765 IPGLPSLTTTVVQATPKSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEG 824
+P +PS++T + + + + K T++ E T + ++ ++E+++ K++EG
Sbjct: 426 LPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT--EEVTEEEEKEAKEEEG 483
Query: 825 KETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLN--KNEGLANGLSESQESRMASIKAE 882
KE + + G E++K + K+ + K E + ++S E A AE
Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543
Query: 883 ADKVYTFTDNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTS-SPAYSD 941
+ A SP+ A + + +P V + A+S A + + SPA +
Sbjct: 544 VKS----PEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK 599
Query: 942 ISDAA-----DDGGSDSRSEG-MRSKASSPSDIISSKDSVV----KGHSSTTAQSSQLKE 991
+ A ++ S + ++ ++ +A SP+++ S + + + S A+S + +E
Sbjct: 600 SPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEE 659
Query: 992 SHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMK--IKKESE----------EDAE 1039
+ SP + P + + P + +P + S + K +K+E++ E+A+
Sbjct: 660 AKSPE-KAKSPVKAEA-KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
Query: 1040 KKDKAE---QLDSKKVDHNSASLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMA 1096
+KA+ + ++K + + ++ + +S + P A++L D KS A
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL-----------DVKSPEA 766
Query: 1097 TSPAY---RQQYEKYYEDQRLA---EQKMAQTGRGDCERKSELPLKELGKEE-----TKQ 1145
+PA R +K+ E + E K + + + ++ P KE+ K+E K+
Sbjct: 767 KTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKE 826
Query: 1146 KNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKAKQMEN 1205
+ P K P P K + P+ P KTEE S+ +++ + K+
Sbjct: 827 EEKPQEVKVKEP----PKKAEEEKAPATP-KTEEKKDSKKEEAPKKEAPKPKVEEKKEPA 881
Query: 1206 HQLIKEA-VEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDREK 1264
+ KE+ VE K K+ P + + D + E+ + K
Sbjct: 882 VEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE-----------DAKPKEKTEVAK 930
Query: 1265 KLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPVNWKD 1324
K +D+ K P+K + KEE +AK P+ + E+K K DD+
Sbjct: 931 KEPDDAKAKEPSKPAEKKEAAPEKKDTKEE--KAKKPEEKPKTEAKAKEDDKTLSKEPSK 988
Query: 1325 SRGTRVAVSSPMSQHQS 1341
+ + SS Q S
Sbjct: 989 PKAEKAEKSSSTDQKDS 1005
>gi|57864582 hornerin [Homo sapiens]
Length = 2850
Score = 62.4 bits (150), Expect = 3e-09
Identities = 53/216 (24%), Positives = 88/216 (40%), Gaps = 20/216 (9%)
Query: 51 NNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSK 110
+ S + S S S+ G S + + G ++S + G+ H + RS
Sbjct: 1939 HGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSG 1998
Query: 111 TSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNST 170
S G + S+ G+ G A+G +S+ GQ +S SG +S+
Sbjct: 1999 QSS------------GYGQHGSSSGHSSTHGQHGSASGQSSSCGQHGAS--SGQSSSHGQ 2044
Query: 171 STSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAP 230
S S+ ++G G G + PG Q G+++ G +H G + SG P
Sbjct: 2045 HGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYG-----RHGSGSGRSSSSGQHGP 2099
Query: 231 SGGHLYGFG-AKSNGGGASPFHCGGTGSGSVAAAGE 265
G GFG +S+ G +S + G+GSG + G+
Sbjct: 2100 GLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQ 2135
Score = 59.7 bits (143), Expect = 2e-08
Identities = 44/147 (29%), Positives = 64/147 (43%), Gaps = 14/147 (9%)
Query: 140 QGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSR 199
QGR G +G +S+ GQ SS SG +S S S +G G G + PG Q
Sbjct: 841 QGRHGSTSGQSSSSGQHDSS--SGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGS 898
Query: 200 GAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGS 259
G+ + G+ H G + SG G GFG KS+ G +S + G+GSG
Sbjct: 899 GSGQSPSYGR-----HGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGH 953
Query: 260 VAA-------AGEVSKSAPDSGLMGNS 279
++ +G+ S+S G+S
Sbjct: 954 SSSYEQHGSRSGQSSRSEQHGSSSGSS 980
Score = 57.0 bits (136), Expect = 1e-07
Identities = 52/216 (24%), Positives = 88/216 (40%), Gaps = 20/216 (9%)
Query: 51 NNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSK 110
+ S + S S S+ G S + + + G ++S + G+SH + RS
Sbjct: 1469 HGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSG 1528
Query: 111 TSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNST 170
S G + S+ G+ G +G +S+ GQ +S SG +S+
Sbjct: 1529 QSS------------GYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGAS--SGQSSSHGQ 1574
Query: 171 STSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAP 230
S S+ ++G G G + PG Q G+++ G+ Q+GSG
Sbjct: 1575 HGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGES 1634
Query: 231 SG-GHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGE 265
SG GH +S+ G +S + G+GSG + G+
Sbjct: 1635 SGFGH-----HESSSGQSSSYSQHGSGSGHSSGYGQ 1665
Score = 55.5 bits (132), Expect = 4e-07
Identities = 51/216 (23%), Positives = 87/216 (40%), Gaps = 20/216 (9%)
Query: 51 NNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSK 110
+ S + S S S+ G S + + + G ++S + G+ H + RS
Sbjct: 2409 HGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSG 2468
Query: 111 TSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNST 170
S G + S+ G+ G +G +S+ GQ +S SG +S+
Sbjct: 2469 QSS------------GYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGAS--SGQSSSHGQ 2514
Query: 171 STSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAP 230
S S+ ++G G G + PG Q G+++ G+ Q+GSG
Sbjct: 2515 HGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGES 2574
Query: 231 SG-GHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGE 265
SG GH +S+ G +S + G+GSG + G+
Sbjct: 2575 SGFGH-----HESSSGQSSSYSQHGSGSGHSSGYGQ 2605
Score = 54.7 bits (130), Expect = 7e-07
Identities = 51/216 (23%), Positives = 86/216 (39%), Gaps = 20/216 (9%)
Query: 51 NNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSK 110
+ S + S S S+ G S + + G ++S + G+ H + RS
Sbjct: 999 HGSGSGQSPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSG 1058
Query: 111 TSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNST 170
S G + S+ G+ G +G +S+ GQ +S SG +S+
Sbjct: 1059 QSS------------GYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGAS--SGQSSSHGQ 1104
Query: 171 STSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAP 230
S S+ ++G G G + PG Q G+++ G+ Q+GSG
Sbjct: 1105 HGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGES 1164
Query: 231 SG-GHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGE 265
SG GH +S+ G +S + G+GSG + G+
Sbjct: 1165 SGFGH-----HESSSGQSSSYSQHGSGSGHSSGYGQ 1195
Score = 52.8 bits (125), Expect = 3e-06
Identities = 58/224 (25%), Positives = 85/224 (37%), Gaps = 25/224 (11%)
Query: 58 SSSNSKDCGGPASSGAGATAALADGLKFASVQASA----PQGNSHKETSKSKVKRSKTSK 113
S S GP S +G ++ G K S Q+S G+SH + RS S
Sbjct: 680 SGSGWSSSNGPHGSVSGQSSGF--GHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSS 737
Query: 114 DANKSLPSAALYGIPEISSTGKRQEV-QGRPGEATGMN-SALGQSVSSGGSGNPNSNSTS 171
+ + S+ L +G Q GR G +G + S + SSG S + + +
Sbjct: 738 RSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSSHGQHGSG 797
Query: 172 TSTSAAT----AGAGSCGKSKEEKPGKSQ------------SSRGAKRDKDAGKSRKDKH 215
TS S++ +G+G + + G Q SS+G S +H
Sbjct: 798 TSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQH 857
Query: 216 DLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGS 259
D G + G + H G G +G G SP H G GSGS
Sbjct: 858 DSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGH-GQRGSGS 900
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/233 (25%), Positives = 93/233 (39%), Gaps = 28/233 (12%)
Query: 42 EKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKET 101
E++ + E N ++ S +S G S +L G + S + S + S +
Sbjct: 111 EQEETEKEENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRRLSFQRDFSGQHN 170
Query: 102 SKSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGG 161
S S S YG E +S + +G+ G +G + GQ S G
Sbjct: 171 SYSGQSSS---------------YG--EQNSDSHQSSGRGQCGSGSGQSPNYGQHGS--G 211
Query: 162 SGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGK--SRKDKHDLLQ 219
SG +SN T S S ++G S + G SQ G+ G+ SR + +
Sbjct: 212 SGQSSSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGE 271
Query: 220 GHQNGSGSQAPSGGH------LYGFGAKSNGGGASPFHC-GGTGSGSVAAAGE 265
H++ SGS + G H G G + +G SP H G+GSG ++ G+
Sbjct: 272 RHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQ 324
Score = 51.2 bits (121), Expect = 7e-06
Identities = 60/227 (26%), Positives = 92/227 (40%), Gaps = 29/227 (12%)
Query: 58 SSSNSKDCGGPASSGAGATAALADGLKFA--SVQASAPQGNSHKETSKSKVKRSKTSKDA 115
S S G S AG++++ + S+ S S + S S+ + S+ +
Sbjct: 496 SRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQS 555
Query: 116 NKSLPSAALYGIPEISSTGKRQEVQGRPG------EATGMNSALGQSVSSGGSGNPNSNS 169
+ P YG SS G + G +G +S GQ SS G + +
Sbjct: 556 SSYGPHG--YGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQH 613
Query: 170 TSTSTSAATAG-----AGSCGKSKEEKPGKSQSSRGAKRDKDAGKS-RKDKHDLLQGH-- 221
STS +++ G +G + G SQSSR ++ +G+S + +H GH
Sbjct: 614 GSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSS 673
Query: 222 ---QNGSGS-----QAPSG---GHLYGFGAKSNGGGASPFHCGGTGS 257
Q+GSGS P G G GFG KS G +S + G+GS
Sbjct: 674 SYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGS 720
Score = 49.7 bits (117), Expect = 2e-05
Identities = 58/242 (23%), Positives = 92/242 (38%), Gaps = 23/242 (9%)
Query: 48 FEMNNSTTTTSSSNSKDCGGPA-SSGAGATAALAD----GLKFASVQASAPQGNSHKETS 102
F + S++ SS S+ G SSG G + + G + S S+ H S
Sbjct: 231 FSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGS 290
Query: 103 KSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQE--------VQGRPGEATGMNSALG 154
+ + + + +S PS +G S+ Q +G +G S G
Sbjct: 291 RQSLGHGRQGSGSRQS-PSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFG 349
Query: 155 QSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDK 214
Q S GSG + S S S ++ G G + + Q +++ G+
Sbjct: 350 QHES--GSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQ----- 402
Query: 215 HDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFH-CGGTGSGSVAAAGE-VSKSAPD 272
H+ H +G G + G G G + +G G SP GTG G +++G VS S
Sbjct: 403 HESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYS 462
Query: 273 SG 274
SG
Sbjct: 463 SG 464
Score = 46.6 bits (109), Expect = 2e-04
Identities = 69/253 (27%), Positives = 108/253 (42%), Gaps = 38/253 (15%)
Query: 58 SSSNSKDCGGPASSGAGATAALAD-GLKFASVQASAPQGNSHKETSKSKVKRSKTSKDAN 116
S S G SG+G ++A + G + G++ ++S + S T + ++
Sbjct: 1276 SRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSS 1335
Query: 117 ---KSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQ-------SVSSG--GSGN 164
+ S+ G + + +GR G +G +S+ GQ S SSG GSG+
Sbjct: 1336 YGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGS 1395
Query: 165 PNSN------STSTSTSAATA-GAGSCGKSKEEKPGK--SQSSRGAKRDKDAGKSR---- 211
S+ S+S +S T G+GS S E+ G QSSRG + +G S
Sbjct: 1396 GQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQ 1455
Query: 212 --KDKHDLLQGHQNGSGS-QAPS---GGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGE 265
L Q+GSGS Q+PS G H G G S+ SP+ G+GSG ++ G
Sbjct: 1456 HGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSS---YSPY---GSGSGWSSSRGP 1509
Query: 266 VSKSAPDSGLMGN 278
+ S +G+
Sbjct: 1510 YESGSSHSSGLGH 1522
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/248 (27%), Positives = 103/248 (41%), Gaps = 31/248 (12%)
Query: 49 EMNNSTTTTSSSNSKDCGGPASSGA-GATAALADGLKFASVQASAPQGNSHKETSKSKVK 107
E + ++ S + G S G G+T+ + F +S Q +SH + +
Sbjct: 1758 ESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSS--TFDQEGSSTGQSSSHGQHGSGSSQ 1815
Query: 108 RSKTSKDANKS--LPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGG--SG 163
S + + S PS +G S G+ G +G +S+ G+ S G SG
Sbjct: 1816 SSSYGQQGSGSGQSPSRGRHG-----SGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSG 1870
Query: 164 NPNSNSTSTSTSAATA-GAGSCGKSKEEKPGK--SQSSRGAKRDKDAGKSR------KDK 214
+ S+S +S T G+GS S E+ G QSSRG + +G S
Sbjct: 1871 FGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYGQHGSGS 1930
Query: 215 HDLLQGHQNGSGS-QAPS---GGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSA 270
L Q+GSGS Q+PS G H G G S+ G P+ G+GSG ++ G +
Sbjct: 1931 RQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYG---PY---GSGSGWSSSRGPYESGS 1984
Query: 271 PDSGLMGN 278
S +G+
Sbjct: 1985 GHSSGLGH 1992
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/248 (27%), Positives = 103/248 (41%), Gaps = 31/248 (12%)
Query: 49 EMNNSTTTTSSSNSKDCGGPASSGA-GATAALADGLKFASVQASAPQGNSHKETSKSKVK 107
E + ++ S + G S G G+T+ + F +S Q +SH + +
Sbjct: 2228 ESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSS--TFDQEGSSTGQSSSHGQHGSGSSQ 2285
Query: 108 RSKTSKDANKS--LPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGG--SG 163
S + + S PS +G S G+ G +G +S+ G+ S G SG
Sbjct: 2286 SSSYGQQGSGSGQSPSRGRHG-----SGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSG 2340
Query: 164 NPNSNSTSTSTSAATA-GAGSCGKSKEEKPGK--SQSSRGAKRDKDAGKSR------KDK 214
+ S+S +S T G+GS S E+ G QSSRG + +G S
Sbjct: 2341 FGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGS 2400
Query: 215 HDLLQGHQNGSGS-QAPS---GGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSA 270
L Q+GSGS Q+PS G H G G S+ SP+ G+GSG ++ G +
Sbjct: 2401 RQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSS---YSPY---GSGSGWSSSRGPYESGS 2454
Query: 271 PDSGLMGN 278
S +G+
Sbjct: 2455 GHSSGLGH 2462
Score = 45.8 bits (107), Expect = 3e-04
Identities = 69/261 (26%), Positives = 103/261 (39%), Gaps = 46/261 (17%)
Query: 48 FEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQ--ASAPQGNS---HKETS 102
F + S + SS SK G S + G +S Q +S+ Q +S H+ S
Sbjct: 348 FGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESAS 407
Query: 103 KSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGG- 161
+ R + S + +S G + S + G+ G G +S+ G VS G
Sbjct: 408 RHSSGRGQHSSGSGQSP------GHGQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGY 461
Query: 162 -SGNPNSNSTSTSTSAATA-GAGSCGKSKEEKPGK--SQSSRGAKRDKDAGKSRK----- 212
SG + S+S +S T G+GS S + G QSSRG ++ AG S
Sbjct: 462 SSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHG 521
Query: 213 ---------DKHDLLQG---------HQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGG 254
+H G H++GS + G H YG G S+ G P+
Sbjct: 522 SGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRG---PYE--- 575
Query: 255 TGSGSVAAAG-EVSKSAPDSG 274
+GSG + G + S+S SG
Sbjct: 576 SGSGHSSGLGHQESRSGQSSG 596
Score = 45.4 bits (106), Expect = 4e-04
Identities = 61/227 (26%), Positives = 90/227 (39%), Gaps = 23/227 (10%)
Query: 52 NSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKT 111
+ T+ +SS + G +SG G + G + S SA S + S +S +
Sbjct: 796 SGTSCSSSCGHYESGSGQASGFGQHES-GSGQGY-SQHGSASGHFSSQGRHGSTSGQSSS 853
Query: 112 SKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMN-------SALGQSVSSG---- 160
S + S ++ YG E S +GR G +G + S GQS S G
Sbjct: 854 SGQHDSSSGQSSSYGQHE--SASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGS 911
Query: 161 GSGNPNSNSTSTSTSAATAGAG---SCGKSK---EEKPGKSQSSRGAKRDKDAGKS-RKD 213
GSG +S+ S S ++G G S G+S + G SS + +G+S R +
Sbjct: 912 GSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSE 971
Query: 214 KHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGT-GSGS 259
+H G + G G G +G G SP G GSGS
Sbjct: 972 QHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGS 1018
Score = 43.5 bits (101), Expect = 0.002
Identities = 61/262 (23%), Positives = 93/262 (35%), Gaps = 35/262 (13%)
Query: 58 SSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANK 117
S S GP SG+G ++ L + + Q S S + + TS ++
Sbjct: 1029 SGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSS 1088
Query: 118 SLPSAALYGIPEISSTGK------RQEVQGRPGEATGMNSALGQSVSSG----------- 160
A G + SS G+ + GR G +G + GQ S
Sbjct: 1089 CGQHGASSG--QSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGS 1146
Query: 161 GSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGK--SRKDKHDLL 218
GSG +S+ S ++G G S + SQ G+ G+ SR +
Sbjct: 1147 GSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRG 1206
Query: 219 QGHQNGSGSQAPSGGH------LYGFGAKSNGGGASPF---HCGGTGSGSV-----AAAG 264
+ H + SGS + G H G G + +G G SP H G G S + +G
Sbjct: 1207 ERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSG 1266
Query: 265 EVSKSAPDSGLMGNSMLVKKEE 286
S P G+S + + E
Sbjct: 1267 RSSSRGPYESRSGHSSVFGQHE 1288
Score = 43.1 bits (100), Expect = 0.002
Identities = 50/229 (21%), Positives = 89/229 (38%), Gaps = 32/229 (13%)
Query: 49 EMNNSTTTTSS------SNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETS 102
E + S++ +SS S S+ G G+G+ + + G + + S+ G +
Sbjct: 1677 ERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSG 1736
Query: 103 KSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQE------VQGRPGEATGMNSALGQS 156
+S + S+ + S+ G S+ + QG+ G +G +S Q
Sbjct: 1737 RSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQE 1796
Query: 157 VSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHD 216
SS +G +S+ S S+ ++ G G + P + + G+ G+
Sbjct: 1797 GSS--TGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQ------- 1847
Query: 217 LLQGHQNGSGSQAPSGGHLYGFGAKSNGG-------GASPFHCGGTGSG 258
H +GSG + SG H G G S G +S + G+GSG
Sbjct: 1848 ----HGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSG 1892
Score = 43.1 bits (100), Expect = 0.002
Identities = 49/218 (22%), Positives = 81/218 (37%), Gaps = 23/218 (10%)
Query: 67 GPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYG 126
G +SS L + F ++S+ Q +S+ + S + ++S S
Sbjct: 2089 GRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQS----- 2143
Query: 127 IPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGK 186
S G+R G ++G +S GQ S + + S S + + G G
Sbjct: 2144 -----SRGERH------GSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGS 2192
Query: 187 SKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSG-----SQAPSG-GHLYGFGA 240
G+ S G + +SR + H++GSG SQ SG GH G
Sbjct: 2193 GHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ 2252
Query: 241 K-SNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMG 277
S G +S F G+ +G ++ G+ + S G
Sbjct: 2253 HGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYG 2290
Score = 42.7 bits (99), Expect = 0.003
Identities = 45/213 (21%), Positives = 76/213 (35%), Gaps = 13/213 (6%)
Query: 67 GPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYG 126
G +SS + L + F ++S+ Q +S+ + S + ++S S
Sbjct: 1619 GRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQS----- 1673
Query: 127 IPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGK 186
S G+R R G + + G SSG + + S S +G G
Sbjct: 1674 -----SRGERHGSSSRSSSRYGQHGS-GSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSS 1727
Query: 187 SKEEKPGKSQSS-RGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAK-SNG 244
+ G +SS RG + S +H+ GH + GH G S
Sbjct: 1728 HGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTS 1787
Query: 245 GGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMG 277
G +S F G+ +G ++ G+ + S G
Sbjct: 1788 GQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYG 1820
Score = 42.4 bits (98), Expect = 0.003
Identities = 43/182 (23%), Positives = 72/182 (39%), Gaps = 14/182 (7%)
Query: 100 ETSKSKVKRSKTSKDANKSLPSA---ALYGIPEISSTGKRQEVQGRPGEATGMNSALGQS 156
+T + + ++ +T K+ NK S+ + + E S + +PG + Q
Sbjct: 104 DTHQHQEEQEETEKEENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRRLSFQR 163
Query: 157 VSSGG----SGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRK 212
SG SG +S S S ++G G CG + P Q G+ + S
Sbjct: 164 DFSGQHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGSGSGQS-----SSN 218
Query: 213 DKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGG-ASPFHCGGTGSGSVAAAGEVSKSAP 271
D H G +G S G G+ +G G +S + G+ SG ++ GE +S+
Sbjct: 219 DTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQ-SSRGERHRSSS 277
Query: 272 DS 273
S
Sbjct: 278 GS 279
Score = 41.6 bits (96), Expect = 0.006
Identities = 53/229 (23%), Positives = 82/229 (35%), Gaps = 22/229 (9%)
Query: 57 TSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDAN 116
+SSS G SSG G + + S S +S S+ +S +
Sbjct: 1151 SSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHG 1210
Query: 117 KSLPSAALYGIPEISSTGKRQEVQGRPGEATGMN-------SALGQSVSSGGSGNPNSNS 169
S S++ YG + S ++ GR G +G + S LG S S G G+ + S
Sbjct: 1211 SSSGSSSHYG--QHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRS 1268
Query: 170 TSTSTSAATAGAGSCGKSKEEKPGKSQS------------SRGAKRDKDAGKSRKDKHDL 217
+S + +G S E G S + S+G S D+
Sbjct: 1269 SSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGS 1328
Query: 218 LQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFH-CGGTGSGSVAAAGE 265
G + G + G+G G G SP G+GSG ++ G+
Sbjct: 1329 STGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQ 1377
Score = 41.6 bits (96), Expect = 0.006
Identities = 46/209 (22%), Positives = 81/209 (38%), Gaps = 25/209 (11%)
Query: 49 EMNNSTTTTSS------SNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETS 102
E + S++ +SS S S+ G G+G+ + + G + + S+ G +
Sbjct: 1207 ERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSG 1266
Query: 103 KSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQE------VQGRPGEATGMNSALGQS 156
+S + S+ + S+ G S+ + QG+ G +G +S Q
Sbjct: 1267 RSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQE 1326
Query: 157 VSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHD 216
SS +G +S S S+ ++G G G + P + + G+ G+
Sbjct: 1327 GSS--TGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQ------- 1377
Query: 217 LLQGHQNGSGSQAPSGGHLYGFGAKSNGG 245
H +GSG + SG H G G S G
Sbjct: 1378 ----HGSGSGWSSSSGRHGSGSGQSSGFG 1402
Score = 41.2 bits (95), Expect = 0.008
Identities = 49/218 (22%), Positives = 81/218 (37%), Gaps = 23/218 (10%)
Query: 67 GPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYG 126
G +SS + L + F ++S+ Q +S+ + S + ++S S
Sbjct: 1149 GRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQS----- 1203
Query: 127 IPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGK 186
S G+R G ++G +S GQ S + + S S + + G G
Sbjct: 1204 -----SRGERH------GSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGL 1252
Query: 187 SKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSG-----SQAPSG-GHLYGFGA 240
G+ S G + +SR + H++GSG SQ SG GH G
Sbjct: 1253 GHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ 1312
Query: 241 K-SNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMG 277
S G +S F G+ +G ++ G + S G
Sbjct: 1313 HGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYG 1350
Score = 41.2 bits (95), Expect = 0.008
Identities = 50/229 (21%), Positives = 88/229 (38%), Gaps = 32/229 (13%)
Query: 49 EMNNSTTTTSS------SNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETS 102
E + S++ +SS S S+ G G+G+ + + G + S+ G +
Sbjct: 2147 ERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSGSG 2206
Query: 103 KSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQE------VQGRPGEATGMNSALGQS 156
+S + S+ + S+ G S+ + QG+ G +G +S Q
Sbjct: 2207 RSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQE 2266
Query: 157 VSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHD 216
SS +G +S+ S S+ ++ G G + P + + G+ G+
Sbjct: 2267 GSS--TGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQ------- 2317
Query: 217 LLQGHQNGSGSQAPSGGHLYGFGAKSNGG-------GASPFHCGGTGSG 258
H +GSG + SG H G G S G +S + G+GSG
Sbjct: 2318 ----HGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSG 2362
Score = 40.8 bits (94), Expect = 0.010
Identities = 49/218 (22%), Positives = 81/218 (37%), Gaps = 23/218 (10%)
Query: 67 GPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYG 126
G +SS + L + F ++S+ Q +S+ + S + ++S S
Sbjct: 2559 GRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQS----- 2613
Query: 127 IPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGK 186
S G+R G ++G +S GQ S + + S S + + G G
Sbjct: 2614 -----SRGERH------GSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGL 2662
Query: 187 SKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSG-----SQAPSG-GHLYGFGA 240
G+ S G + +SR + H++GSG SQ SG GH G
Sbjct: 2663 GHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ 2722
Query: 241 K-SNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMG 277
S G +S F G+ +G ++ G + S G
Sbjct: 2723 HGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYG 2760
Score = 38.1 bits (87), Expect = 0.065
Identities = 51/234 (21%), Positives = 91/234 (38%), Gaps = 25/234 (10%)
Query: 49 EMNNSTTTTSS------SNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETS 102
E + S++ +SS S S+ G G+G+ + + G + + S+ G +
Sbjct: 2617 ERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSG 2676
Query: 103 KSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGS 162
+S + S+ L ++++G E S + G +G + GQ S+ G
Sbjct: 2677 RSSSRGPYESR-----LGHSSVFGQHESGSG--HSSAYSQHGSGSGHFCSQGQHGSTSGQ 2729
Query: 163 GNP---NSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQ 219
+ +ST S+S G+GS S G + G+ + G+
Sbjct: 2730 SSTFDQEGSSTGQSSSYGHRGSGSSQSS-----GYGRHGAGSGQSLSHGRHGSGSGQSSS 2784
Query: 220 GHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDS 273
Q+GSGS SG +G G+ +G +C G + ++G S P S
Sbjct: 2785 YGQHGSGSGQSSGYSQHGSGSGQDGYS----YCKGGSNHDGGSSGSYFLSFPSS 2834
>gi|28559039 mediator complex subunit 1 [Homo sapiens]
Length = 1581
Score = 58.2 bits (139), Expect = 6e-08
Identities = 85/332 (25%), Positives = 130/332 (39%), Gaps = 56/332 (16%)
Query: 5 ISTAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKD 64
IS AGK + P + + SG G L+ D EK +++ + N T+ ++ S
Sbjct: 934 ISVAGKALAPADLMEHHSGSQ-----GPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGL 988
Query: 65 CGGPAS-----SGAGATAALADGLKFASVQASAPQGNSHKE--TSKSKVKRSKTSKDANK 117
P S G + K A + +P +S T + SK+ A +
Sbjct: 989 DSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGR 1048
Query: 118 SL--PSAALYGIPEIS-STGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTST 174
S P A IP+I+ K + G+P + S+ SVSS GS + +S+S+S+S+
Sbjct: 1049 SQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSS--GSVSSSGSKSHHSHSSSSSS 1106
Query: 175 SAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGH 234
SA+T+G KS+ K SS + Q SGS
Sbjct: 1107 SASTSGKMKSSKSEGSSSSKLSSS-------------------MYSSQGSSGSSQSK--- 1144
Query: 235 LYGFGAKSNGG--GASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESH 292
+ +GG G+SP G SGS ++ ++ S LM S+ + SH
Sbjct: 1145 ----NSSQSGGKPGSSPITKHGLSSGS--SSTKMKPQGKPSSLMNPSL---SKPNISPSH 1195
Query: 293 RRIKKLKTEKVDPLFTVPAPPP------PISS 318
R + P+ VP PP PISS
Sbjct: 1196 SRPPGGSDKLASPMKPVPGTPPSSKAKSPISS 1227
Score = 50.8 bits (120), Expect = 1e-05
Identities = 124/642 (19%), Positives = 218/642 (33%), Gaps = 74/642 (11%)
Query: 430 GGRGRGKRARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRRTPPNCAAED 489
G G+ K + G+ S GL +K + R S + + PP D
Sbjct: 961 GDLGKEKTQKRVKEGNGTSNSTLSGPGLDSK----PGKRSRTPSNDGKSKDKPPKRKKAD 1016
Query: 490 IKA-SPS-STNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGC 547
+ SPS S++ R PP S+ PG R+ + TP T + +G
Sbjct: 1017 TEGKSPSHSSSNRPFTPP-----TSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGT 1071
Query: 548 SSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKI-SDCEEGLSNVA 606
+ P+ + +Y + + +H + + K+ S EG S+
Sbjct: 1072 -----VMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSK 1126
Query: 607 LECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGL 666
L S S+ S+ +S G P +P K L S+G S GK S
Sbjct: 1127 LSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGL-SSGSSSTKMKPQGKPSSLMNPS 1185
Query: 667 NNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTD 726
++ N P S D ++ + P +A+ I + G G +++
Sbjct: 1186 LSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGM-- 1243
Query: 727 KNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSPPLK 786
K+ S L S+ ++ TPP + ++ + +++G+ + S + KSP
Sbjct: 1244 KSSSGLGSSGSLSQK---TPPSSNSCTASSSSFSSSGS--SMSSSQNQHGSSKGKSPSRN 1298
Query: 787 PIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGAS 846
P+L ++ DK K G T P + L+ G S
Sbjct: 1299 K--------------KPSLTAVIDKLK---------HGVVTSGPGGE---DPLDGQMGVS 1332
Query: 847 KDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLEC 906
+ H + N + G G E + + + V + + S ++GS +
Sbjct: 1333 TNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKI 1392
Query: 907 S-TLVNGQAPMAPLHVLTQNGAESSAA--KTSSPAYSDISDAADDGGSDSRSEGMRSKAS 963
+ +G +P V Q ESS + + + G + G S +
Sbjct: 1393 IISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSK 1452
Query: 964 SPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSG 1023
SP+ + DS + SS +S Q S Y
Sbjct: 1453 SPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEY-------------------- 1492
Query: 1024 STQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQS 1065
ST+ K K+ ++ + KD+ D + S S++P+ S
Sbjct: 1493 STEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWS 1534
Score = 41.2 bits (95), Expect = 0.008
Identities = 72/324 (22%), Positives = 115/324 (35%), Gaps = 61/324 (18%)
Query: 48 FEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVK 107
+ S+ ++ S NS GG S L+ G +S PQG K +S
Sbjct: 1132 YSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSG---SSSTKMKPQG---KPSSLMNPS 1185
Query: 108 RSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNS 167
SK + + S P G +++S K P T +S +SSG G+ S
Sbjct: 1186 LSKPNISPSHSRPPG---GSDKLASPMK-------PVPGTPPSSKAKSPISSGSGGSHMS 1235
Query: 168 NSTSTSTSAATAGAGSCGKSKEEKP--------------------GKSQSSRGAKRDKDA 207
++S+S +++G GS G ++ P SQ+ G+ + K
Sbjct: 1236 GTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSP 1295
Query: 208 GKSRKD---------KHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFH--CGGTG 256
+++K KH ++ +G G + P G + G S+ S H GG
Sbjct: 1296 SRNKKPSLTAVIDKLKHGVV---TSGPGGEDPLDGQM-GVSTNSSSHPMSSKHNMSGGEF 1351
Query: 257 SGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKTEKVD-------PLFTV 309
G + + SG +S K E + + K+ K D T+
Sbjct: 1352 QGKREKSDKDKSKVSTSGSSVDSS-KKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTL 1410
Query: 310 PAPPPPISSSLTPQILPS--YFSP 331
P L PQ+ S Y SP
Sbjct: 1411 QKPGESSGEGLRPQMASSKNYGSP 1434
Score = 31.6 bits (70), Expect = 6.1
Identities = 60/259 (23%), Positives = 106/259 (40%), Gaps = 40/259 (15%)
Query: 778 ATPKSPPLKPIQPKPTI--MGEPITVNPALVSL-KDKKKKEKRKLK-----DKEGKETGS 829
+T S P P P + M +P L++L KD ++ L +++ +GS
Sbjct: 616 STIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGS 675
Query: 830 PKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESR--MASIKAEADKVY 887
P+M+ G + K S LP K H +++ S +S+ + + AD +
Sbjct: 676 PRMEICSGSNKTKKKKSSRLPPEKPK-HQTEDDFQRELFSMDVDSQNPIFDVNMTADTLD 734
Query: 888 TFTDNAPSPSIGSASRLECST-LVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDI-SDA 945
T P+PS +CST P+ Q S++ + P +DI SD
Sbjct: 735 T-PHITPAPS-------QCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDI 786
Query: 946 ADDGGSDSRSEGMRSKASSPSDIISS-----KDSVVKGHSSTTAQSSQLKESHSPYYHSY 1000
A++ SK S SD + +DS GHS +T S + +++ ++
Sbjct: 787 AEEA----------SKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTN----NNE 832
Query: 1001 DPYYSPSYMHPGQVGAPAA 1019
+PY P+ + G+P++
Sbjct: 833 NPYTDPADLIADAAGSPSS 851
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 55.8 bits (133), Expect = 3e-07
Identities = 115/513 (22%), Positives = 174/513 (33%), Gaps = 93/513 (18%)
Query: 607 LECSEPSTSV----SAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGK 662
++C+EPS ++ + K G G GT S PG+ + K S K
Sbjct: 2286 IQCAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAG------SEEPGAKARGRGRKPSAK 2339
Query: 663 KKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATN 722
KG + A L+ +G+ E+P L G K+ + +
Sbjct: 2340 AKG------------DRAATLE-----EGNPTDEVPSTPL-ALEPSSTPGSKKSPPEPVD 2381
Query: 723 CKTDKNLSKLKSARPIAPAPAPTPPQLIAIPT----ATFTTTTTGTIPGLPSLTTTVVQA 778
+ +K ARP P P+P PP + P A T P P +T +
Sbjct: 2382 KR-----AKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPA-PLITMPATRP 2435
Query: 779 TPKSP----------PLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEG---- 824
PK P +P + ++ + + S K KK KE L++ G
Sbjct: 2436 KPKKARAAEESGAKGPRRPGEEAELLVK---LDHEGVTSPKSKKAKEALLLREDPGAGGW 2492
Query: 825 -------------KETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLN-----KNEGLAN 866
GS + A K D A + PG +D N K + +
Sbjct: 2493 QEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQD 2552
Query: 867 GLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNG 926
G ES+ S +S + + ++ S S GS + E NG G
Sbjct: 2553 GAEESESSSSSSSGSS-------SSSSSSSSSGSETEGEEEGDKNGDGGCG------TGG 2599
Query: 927 AESSAA--KTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTA 984
SAA + +SPA S S ++ S S S S +SS S SS S SS+++
Sbjct: 2600 RNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2659
Query: 985 QSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKA 1044
SS S S D S APA S Q K +++ + + A
Sbjct: 2660 SSSSSSSSSSSSTTDED-----SSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSA 2714
Query: 1045 EQLDSKKVDHNSASLQPQHQSVITQRHPALAQS 1077
K + PQ + + A A+S
Sbjct: 2715 HSPGKKTPAPQPQAPPPQPTQPLQPKAQAGAKS 2747
Score = 47.0 bits (110), Expect = 1e-04
Identities = 81/394 (20%), Positives = 128/394 (32%), Gaps = 68/394 (17%)
Query: 209 KSRKDKHDLLQGHQNGS-GSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVS 267
+SRK D +G G+ GS+ P GAK+ G G P + G +
Sbjct: 2303 RSRKTSKDTGEGKDGGTAGSEEP--------GAKARGRGRKPSAKAKGDRAATLEEGNPT 2354
Query: 268 KSAPDS--GLMGNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSL-TPQI 324
P + L +S K+ E +R K K P P+P PP +S P+
Sbjct: 2355 DEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQ---PSPAPPAFTSCPAPEP 2411
Query: 325 LPSYFSPSSSNIAAPVEQLLVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNL------E 378
+P++S AP L+ + + E GP PG L E
Sbjct: 2412 FAELPAPATSLAPAP----LITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHE 2467
Query: 379 GIV---------------------WHETEE-----------GVLVVNVTWRNKTY----- 401
G+ W E + G W T
Sbjct: 2468 GVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQ 2527
Query: 402 ---VGTLLDCTKHDWAPPRFCESPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESRGLQ 458
G + + + +P + E + S++++ S S TE
Sbjct: 2528 EPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEG 2587
Query: 459 NKNRGGANGKGRRGSLNASGRRTPP---NCAAEDIKASPSSTNKRKNKPPMELDLNSSSE 515
+KN G G G R AS R P + ++ +S SS++ + +SSS
Sbjct: 2588 DKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647
Query: 516 DNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSS 549
+ ++S S+ ++ TT D CSS
Sbjct: 2648 SSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSS 2681
Score = 39.3 bits (90), Expect = 0.029
Identities = 46/215 (21%), Positives = 81/215 (37%), Gaps = 10/215 (4%)
Query: 580 DPENKLEFEPDSEDKISDCEEGLSNVALECSEPSTSVSAYDQLKAPASPGAGNPPGTPKG 639
+P L FE K D + + A E SE S+S S+ + +S +G+ +G
Sbjct: 2528 EPGPGLTFEDSGNPKSPDKAQAEQDGAEE-SESSSSSSSGSSSSSSSSSSSGSET---EG 2583
Query: 640 KRELMSNGPGSI----IGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGSLAA 695
+ E NG G A + ++ ++ S+ +++ S S++ S ++
Sbjct: 2584 EEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643
Query: 696 EMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTA 755
+ + +++ TD++ S S APAP P A+PT
Sbjct: 2644 SSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDED-SSCSSDDEAAPAPTAGPSAQAALPTK 2702
Query: 756 TFTTTTTGTIPGLPSLTTTVVQATPKSPPLKPIQP 790
T P S P++PP +P QP
Sbjct: 2703 A-TKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQP 2736
Score = 37.0 bits (84), Expect = 0.14
Identities = 34/176 (19%), Positives = 66/176 (37%), Gaps = 1/176 (0%)
Query: 112 SKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTS 171
S + P A + + G E G P + + S S + +S S+S
Sbjct: 2510 SSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSS 2569
Query: 172 TSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPS 231
+S+S++++G+ + G+ + +K G G R+ A SR + S S + S
Sbjct: 2570 SSSSSSSSGSETEGEEEGDKNGDGGCGTGG-RNCSAASSRAASPASSSSSSSSSSSSSSS 2628
Query: 232 GGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEE 287
+ S+ +S + S S +++ S S+ S ++E
Sbjct: 2629 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDE 2684
Score = 33.5 bits (75), Expect = 1.6
Identities = 22/91 (24%), Positives = 42/91 (46%), Gaps = 4/91 (4%)
Query: 430 GGRGRGKR----ARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRRTPPNC 485
GG G G R A S AA+P S +S + S + + ++ S ++S + +
Sbjct: 2593 GGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2652
Query: 486 AAEDIKASPSSTNKRKNKPPMELDLNSSSED 516
++ +S SS++ + + D + SS+D
Sbjct: 2653 SSSSSSSSSSSSSSSSSSSTTDEDSSCSSDD 2683
Score = 33.5 bits (75), Expect = 1.6
Identities = 29/139 (20%), Positives = 59/139 (42%), Gaps = 5/139 (3%)
Query: 51 NNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSK 110
++S++++SSS+S +SS + ++++ + +S +S+ +S +S + S
Sbjct: 2620 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSC 2679
Query: 111 TSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNST 170
+S D P+A + + +Q + RP + G+ + P T
Sbjct: 2680 SSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSA-----HSPGKKTPAPQPQAPPPQPT 2734
Query: 171 STSTSAATAGAGSCGKSKE 189
A AGA S K +E
Sbjct: 2735 QPLQPKAQAGAKSRPKKRE 2753
Score = 32.7 bits (73), Expect = 2.7
Identities = 33/149 (22%), Positives = 61/149 (40%), Gaps = 8/149 (5%)
Query: 67 GPASSGAGATAALADGLKFAS-VQASAPQ-----GNSHKETSKSKVKRSKTSKDANKSLP 120
GP++S G+ L L F S ++ P ++H+ S + N P
Sbjct: 76 GPSASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPSYLHLNHLEP 135
Query: 121 SAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAG 180
++ G P +S G+ + G+ G + + + GS + ++ S T ++G
Sbjct: 136 PSS--GSPLLSQLGQPSIFDTQKGQGPGGDGFYLPTAGAPGSLHSHAPSARTPGGGHSSG 193
Query: 181 AGSCGKSKEEKPGKSQSSRGAKRDKDAGK 209
A + G S + P K ++ RG + GK
Sbjct: 194 APAKGSSSRDGPAKERAGRGGEPPPLFGK 222
>gi|4504733 insulin receptor substrate 4 [Homo sapiens]
Length = 1257
Score = 54.7 bits (130), Expect = 7e-07
Identities = 49/185 (26%), Positives = 74/185 (40%), Gaps = 27/185 (14%)
Query: 136 RQEVQGRPGEATGMNS-ALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGK 194
+++ +G G+ MN+ G SGG N +S+ +S G C G+
Sbjct: 477 KEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSS----GGNQCS-------GE 525
Query: 195 SQSSRGAKRDKDAGKS----RKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPF 250
Q SRG + G +D GH +G G Q P GGH +GGG P
Sbjct: 526 GQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSG-GGQRPGGGH-------GSGGGQGPG 577
Query: 251 HCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVP 310
G+G G + G+ S S S G K ++ ++ + K +++ P P
Sbjct: 578 DGHGSGGGKNSGGGKGSGSGKGSDGDGER---GKSLKKRSYFGKLTQSKQQQMPPPPPPP 634
Query: 311 APPPP 315
PPPP
Sbjct: 635 PPPPP 639
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 54.3 bits (129), Expect = 9e-07
Identities = 79/356 (22%), Positives = 131/356 (36%), Gaps = 50/356 (14%)
Query: 476 ASGRRTPPNCAAEDIKA----SPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTP 531
+S + PP+ A++ IK+ SP NK+K K +E SE+ V N S+
Sbjct: 74 SSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIE------SEEITEEHSVSENQESSS 127
Query: 532 TTPQGKPETTFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDS 591
++ +T S + KK K + + +N+ + +P
Sbjct: 128 SSSSSSSSSTIRKIKSSKN---SAANRELQKKLKVKD-----------NKKNRTKKKPTP 173
Query: 592 EDKISD-CEEGLSNVALECSEPSTSVSAYDQLKA--------PASPGAGNPPGTPKGKRE 642
+ + D GL N + + P TS + ++++ P +P PP + K
Sbjct: 174 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 233
Query: 643 LMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGS-----LAAEM 697
++ + + K + K+ + + + T +++ SA D + LA
Sbjct: 234 SLTVNKETTVETKETTTTNKQTSTDGKEKTTS--AKETQSIEKTSAKDLAPTSKVLAKPT 291
Query: 698 PKLEAE----GLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTP----PQL 749
PK E L K + A+ + + +KSA PAPT P
Sbjct: 292 PKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTT 351
Query: 750 IAIPTATFTTTTTGTIPGLPSLTTTVVQA--TPKSPPLKPIQPKPTIMGEPITVNP 803
P T T T P P+ TTT A T KS P P +P PT +P P
Sbjct: 352 PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 407
Score = 42.7 bits (99), Expect = 0.003
Identities = 50/193 (25%), Positives = 61/193 (31%), Gaps = 16/193 (8%)
Query: 612 PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELN 671
P+T+ SA K PA + P TPK + P + + KK
Sbjct: 483 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 542
Query: 672 NLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSK 731
P T + A PK A KE T K
Sbjct: 543 PAP-----TTPKEPAPTTTKKPAPTTPKEPAPTT-------PKETAPTTPKKLTPTTPEK 590
Query: 732 LKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQP 790
L P PAPT P+ +A T T TT P P+ TPK P P P +P
Sbjct: 591 LAPTTP--EKPAPTTPEELAPTTPEEPTPTTPEEPA-PTTPKAAAPNTPKEPAPTTPKEP 647
Query: 791 KPTIMGEPITVNP 803
PT EP P
Sbjct: 648 APTTPKEPAPTTP 660
Score = 37.0 bits (84), Expect = 0.14
Identities = 28/81 (34%), Positives = 32/81 (39%), Gaps = 13/81 (16%)
Query: 733 KSARPIAPA-PAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTT---------VVQATPKS 782
K P P PAPT P+ P T T + T P P+ TTT T KS
Sbjct: 447 KKPAPTTPKEPAPTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 503
Query: 783 PPLKPIQPKPTIMGEPITVNP 803
P P +P PT EP P
Sbjct: 504 APTTPKEPSPTTTKEPAPTTP 524
Score = 33.5 bits (75), Expect = 1.6
Identities = 74/321 (23%), Positives = 101/321 (31%), Gaps = 38/321 (11%)
Query: 493 SPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVL 552
SP++T + P E + + KP T PTTP+ TT ++P
Sbjct: 512 SPTTTKEPAPTTPKE---PAPTTPKKPAPT--TPKEPAPTTPKEPAPTTTKKPAPTTPKE 566
Query: 553 IDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCE-EGLSNVALECSE 611
P P K+ + L P + P + +K + E L+ E
Sbjct: 567 ---PAPTTPKETAPTTPKK-------LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPT 616
Query: 612 PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELN 671
P+T + AP +P A P TPK P + + K+
Sbjct: 617 PTTP-----EEPAPTTPKAA-APNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKG 670
Query: 672 NLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSK 731
P A A LA K DK KG T K +
Sbjct: 671 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP-APTTPKGTAPTTPKEPAPTTP 729
Query: 732 LKSARPIAPA---------PAPTPPQLIA----IPTATFTTTTTGTIPGLPSLTTTVVQA 778
K P P PAPT P+ A PT T T+T + P+
Sbjct: 730 -KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 788
Query: 779 TPKSP-PLKPIQPKPTIMGEP 798
TPK P P P +P PT P
Sbjct: 789 TPKEPAPTTPKKPAPTTPETP 809
Score = 33.1 bits (74), Expect = 2.1
Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 4/63 (6%)
Query: 742 PAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQPKPTIMGEPIT 800
P+PT P+ A PT T + TT P TT TPK P P +P PT EP
Sbjct: 473 PSPTTPKEPA-PTTTKSAPTTTKEPA--PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 529
Query: 801 VNP 803
P
Sbjct: 530 TTP 532
Score = 33.1 bits (74), Expect = 2.1
Identities = 37/158 (23%), Positives = 53/158 (33%), Gaps = 24/158 (15%)
Query: 714 KEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTT 773
K+ K T K + S +P P T P P T T P P TT
Sbjct: 754 KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTT 813
Query: 774 TVV-----------------QATPK---SPPLKPIQPKPTIMGEPITVNPAL----VSLK 809
+ V ++TP+ P K ++ P G P T PA ++
Sbjct: 814 SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTT 873
Query: 810 DKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASK 847
K K +R L+ T +PKM + + SK
Sbjct: 874 AKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESK 911
Score = 32.0 bits (71), Expect = 4.7
Identities = 32/98 (32%), Positives = 38/98 (38%), Gaps = 8/98 (8%)
Query: 742 PAPTPPQLIA----IPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQPKPTIM- 795
PAPT P+ A PT T T+T P+ TPK P P P +P PT
Sbjct: 679 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 738
Query: 796 -GEPITV-NPALVSLKDKKKKEKRKLKDKEGKETGSPK 831
P T+ PA + K KE K T S K
Sbjct: 739 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 776
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 54.3 bits (129), Expect = 9e-07
Identities = 79/356 (22%), Positives = 131/356 (36%), Gaps = 50/356 (14%)
Query: 476 ASGRRTPPNCAAEDIKA----SPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTP 531
+S + PP+ A++ IK+ SP NK+K K +E SE+ V N S+
Sbjct: 115 SSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIE------SEEITEEHSVSENQESSS 168
Query: 532 TTPQGKPETTFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDS 591
++ +T S + KK K + + +N+ + +P
Sbjct: 169 SSSSSSSSSTIRKIKSSKN---SAANRELQKKLKVKD-----------NKKNRTKKKPTP 214
Query: 592 EDKISD-CEEGLSNVALECSEPSTSVSAYDQLKA--------PASPGAGNPPGTPKGKRE 642
+ + D GL N + + P TS + ++++ P +P PP + K
Sbjct: 215 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 274
Query: 643 LMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGS-----LAAEM 697
++ + + K + K+ + + + T +++ SA D + LA
Sbjct: 275 SLTVNKETTVETKETTTTNKQTSTDGKEKTTS--AKETQSIEKTSAKDLAPTSKVLAKPT 332
Query: 698 PKLEAE----GLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTP----PQL 749
PK E L K + A+ + + +KSA PAPT P
Sbjct: 333 PKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTT 392
Query: 750 IAIPTATFTTTTTGTIPGLPSLTTTVVQA--TPKSPPLKPIQPKPTIMGEPITVNP 803
P T T T P P+ TTT A T KS P P +P PT +P P
Sbjct: 393 PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 448
Score = 42.7 bits (99), Expect = 0.003
Identities = 50/193 (25%), Positives = 61/193 (31%), Gaps = 16/193 (8%)
Query: 612 PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELN 671
P+T+ SA K PA + P TPK + P + + KK
Sbjct: 524 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 583
Query: 672 NLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSK 731
P T + A PK A KE T K
Sbjct: 584 PAP-----TTPKEPAPTTTKKPAPTTPKEPAPTT-------PKETAPTTPKKLTPTTPEK 631
Query: 732 LKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQP 790
L P PAPT P+ +A T T TT P P+ TPK P P P +P
Sbjct: 632 LAPTTP--EKPAPTTPEELAPTTPEEPTPTTPEEPA-PTTPKAAAPNTPKEPAPTTPKEP 688
Query: 791 KPTIMGEPITVNP 803
PT EP P
Sbjct: 689 APTTPKEPAPTTP 701
Score = 37.0 bits (84), Expect = 0.14
Identities = 28/81 (34%), Positives = 32/81 (39%), Gaps = 13/81 (16%)
Query: 733 KSARPIAPA-PAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTT---------VVQATPKS 782
K P P PAPT P+ P T T + T P P+ TTT T KS
Sbjct: 488 KKPAPTTPKEPAPTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 544
Query: 783 PPLKPIQPKPTIMGEPITVNP 803
P P +P PT EP P
Sbjct: 545 APTTPKEPSPTTTKEPAPTTP 565
Score = 33.5 bits (75), Expect = 1.6
Identities = 74/321 (23%), Positives = 101/321 (31%), Gaps = 38/321 (11%)
Query: 493 SPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVL 552
SP++T + P E + + KP T PTTP+ TT ++P
Sbjct: 553 SPTTTKEPAPTTPKE---PAPTTPKKPAPT--TPKEPAPTTPKEPAPTTTKKPAPTTPKE 607
Query: 553 IDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCE-EGLSNVALECSE 611
P P K+ + L P + P + +K + E L+ E
Sbjct: 608 ---PAPTTPKETAPTTPKK-------LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPT 657
Query: 612 PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELN 671
P+T + AP +P A P TPK P + + K+
Sbjct: 658 PTTP-----EEPAPTTPKAA-APNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKG 711
Query: 672 NLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSK 731
P A A LA K DK KG T K +
Sbjct: 712 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP-APTTPKGTAPTTPKEPAPTTP 770
Query: 732 LKSARPIAPA---------PAPTPPQLIA----IPTATFTTTTTGTIPGLPSLTTTVVQA 778
K P P PAPT P+ A PT T T+T + P+
Sbjct: 771 -KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 829
Query: 779 TPKSP-PLKPIQPKPTIMGEP 798
TPK P P P +P PT P
Sbjct: 830 TPKEPAPTTPKKPAPTTPETP 850
Score = 33.1 bits (74), Expect = 2.1
Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 4/63 (6%)
Query: 742 PAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQPKPTIMGEPIT 800
P+PT P+ A PT T + TT P TT TPK P P +P PT EP
Sbjct: 514 PSPTTPKEPA-PTTTKSAPTTTKEPA--PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 570
Query: 801 VNP 803
P
Sbjct: 571 TTP 573
Score = 33.1 bits (74), Expect = 2.1
Identities = 37/158 (23%), Positives = 53/158 (33%), Gaps = 24/158 (15%)
Query: 714 KEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTT 773
K+ K T K + S +P P T P P T T P P TT
Sbjct: 795 KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTT 854
Query: 774 TVV-----------------QATPK---SPPLKPIQPKPTIMGEPITVNPAL----VSLK 809
+ V ++TP+ P K ++ P G P T PA ++
Sbjct: 855 SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTT 914
Query: 810 DKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASK 847
K K +R L+ T +PKM + + SK
Sbjct: 915 AKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESK 952
Score = 32.0 bits (71), Expect = 4.7
Identities = 32/98 (32%), Positives = 38/98 (38%), Gaps = 8/98 (8%)
Query: 742 PAPTPPQLIA----IPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQPKPTIM- 795
PAPT P+ A PT T T+T P+ TPK P P P +P PT
Sbjct: 720 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 779
Query: 796 -GEPITV-NPALVSLKDKKKKEKRKLKDKEGKETGSPK 831
P T+ PA + K KE K T S K
Sbjct: 780 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 817
>gi|195976782 Paf1/RNA polymerase II complex component [Homo sapiens]
Length = 710
Score = 52.0 bits (123), Expect = 4e-06
Identities = 61/310 (19%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 1012 GQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSVITQRH 1071
GQ G+P G GS +KK D + + +D SL + +S ++
Sbjct: 24 GQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKE 83
Query: 1072 PALAQSLYYGQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQ--KMAQTGRGDCER 1129
P ++Q D+ + + + + K + + +Q K A +G D +
Sbjct: 84 PPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDS 143
Query: 1130 KSELPLKELGKEETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSNH 1189
+E E G+ N S++ S + S+ E + H G + E+ + + ++
Sbjct: 144 SAESSAPEEGEVSDSDSNSSSSS-SDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEK 202
Query: 1190 QQQLQADSFKAKQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQP 1249
+++ + ++E +++K E+K + + K
Sbjct: 203 EREQEL----FNRIEKREVLKRRFEIKKKLKTAK-------------------------- 232
Query: 1250 KYLDQQKSEELDREKKLKEDSPRK--TPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSME 1307
K E+ +++KK +E+ +K T +ES V S S ++E + K SQ+ME
Sbjct: 233 ------KKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKK---SQAME 283
Query: 1308 ESKLKNDDRK 1317
E K + + RK
Sbjct: 284 ELKAEREKRK 293
Score = 32.0 bits (71), Expect = 4.7
Identities = 63/297 (21%), Positives = 118/297 (39%), Gaps = 56/297 (18%)
Query: 624 APASPGAGNPPGTPKGKRE------LMSNGPGSIIGAKAGKNSGKKKGLNNELNNL---- 673
A A P AG G+P G R ++ G ++ ++SG + L+ EL +L
Sbjct: 16 AVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRK 75
Query: 674 --------PVISNMTAALDS-CSAADGSLAAEMPKLEAEGL---IDKKNLGDKEKGKKAT 721
P +S A+ DS S +D K + +G I+KK K+ K A+
Sbjct: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
Query: 722 NCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTG-----------TIPGLPS 770
+ +DK+ SA AP +++ + ++ + G
Sbjct: 136 SGSSDKD----SSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEE 191
Query: 771 LTTTVVQATPKSPPLKPIQ--PKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETG 828
+ Q T K + K ++ + L + K K+KKEK+K +++E ++
Sbjct: 192 DRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEK-- 249
Query: 829 SPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADK 885
KL ++++S+ S + K+ +K + + S++ E +KAE +K
Sbjct: 250 -----KKLTQIQESQVTSHN------KERRSKRDEKLDKKSQAME----ELKAEREK 291
>gi|62122917 filaggrin family member 2 [Homo sapiens]
Length = 2391
Score = 50.8 bits (120), Expect = 1e-05
Identities = 45/148 (30%), Positives = 62/148 (41%), Gaps = 13/148 (8%)
Query: 137 QEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQ 196
Q G+ G + +S GQ SS SG + S+S +G G G + G Q
Sbjct: 842 QSSYGQHGSGSSQSSGYGQHGSS--SGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQ 899
Query: 197 SSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSG--------GHLYGFGAKSNGGG-A 247
G+ + G+ H G Q+GSGS SG G +GFG +G G +
Sbjct: 900 HGTGSGQYSGFGQHESRSHQSSYG-QHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQS 958
Query: 248 SPFHCGGTGSGSVAAAGE-VSKSAPDSG 274
S F G+GSG + G+ S S SG
Sbjct: 959 SGFGQHGSGSGQSSGFGQHESGSGKSSG 986
Score = 48.1 bits (113), Expect = 6e-05
Identities = 49/197 (24%), Positives = 75/197 (38%), Gaps = 29/197 (14%)
Query: 110 KTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNS 169
+TS L S G + S + G+ G +G +S GQ S G + +S
Sbjct: 563 ETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHS 622
Query: 170 TSTSTSAA--------TAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGK--------SRKD 213
+ +S S+ T+G G G + G Q G+ + G+ S
Sbjct: 623 SGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFG 682
Query: 214 KHDLLQGH----QNGSGSQAPSG--------GHLYGFGA-KSNGGGASPFHCGGTGSGSV 260
+H+ GH Q+G GS SG G GFG + + G +S F G+GSG
Sbjct: 683 QHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQS 742
Query: 261 AAAGEVSKSAPDSGLMG 277
+ G+ + S G
Sbjct: 743 SGFGQHGSGSGQSSGFG 759
Score = 47.0 bits (110), Expect = 1e-04
Identities = 52/213 (24%), Positives = 83/213 (38%), Gaps = 17/213 (7%)
Query: 58 SSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANK 117
S S G SG+G ++ F ++ + Q +S+ + S + S + ++
Sbjct: 585 SGSGQSSGFGQHGSGSGQSSG------FGQHESRSGQ-SSYGQHSSGSSQSSGYGQHGSR 637
Query: 118 SLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGG--SGNPNSNSTSTSTS 175
+G STG G+ G +G +S GQ VS G SG S S +S
Sbjct: 638 QTSGFGQHGSGSSQSTGF-----GQYGSGSGQSSGFGQHVSGSGQSSGFGQHESRSGHSS 692
Query: 176 AATAGAGSCGKSKEEKPGKS--QSSRGAKRDKDAGKSRK-DKHDLLQGHQNGSGSQAPSG 232
G GS S + G S Q+S + + +G+S +H G +G G
Sbjct: 693 YGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSGFGQHGSGS 752
Query: 233 GHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGE 265
G GFG + G S + +GS + G+
Sbjct: 753 GQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQ 785
Score = 47.0 bits (110), Expect = 1e-04
Identities = 65/252 (25%), Positives = 90/252 (35%), Gaps = 26/252 (10%)
Query: 48 FEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHK-------- 99
F + S + SS G SSG G + + G F Q + G S
Sbjct: 910 FGQHESRSHQSSYGQHGSGSSQSSGYGQHGS-SSGQTFGFGQHRSGSGQSSGFGQHGSGS 968
Query: 100 -ETSKSKVKRSKTSKDA----NKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALG 154
++S S + K + ++S S + YG + S + G+ G ++G + G
Sbjct: 969 GQSSGFGQHESGSGKSSGFGQHESRSSQSNYG--QHGSGSSQSSGYGQHGSSSGQTTGFG 1026
Query: 155 QSVSSGG--SGNPNSNSTSTSTSA----ATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAG 208
Q SS G SG S S +S T S G + E + QSS G +
Sbjct: 1027 QHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSR-QSSYGQHGSGSSQ 1085
Query: 209 KSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASP---FHCGGTGSGSVAAAGE 265
S +H G +G G P G GFG +G G S H GTG S A E
Sbjct: 1086 SSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSGFAQHE 1145
Query: 266 VSKSAPDSGLMG 277
G G
Sbjct: 1146 YRSGQSSYGQHG 1157
Score = 46.2 bits (108), Expect = 2e-04
Identities = 52/223 (23%), Positives = 79/223 (35%), Gaps = 10/223 (4%)
Query: 53 STTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTS 112
S+ +SS G SSG G + + S +S+ + S + S
Sbjct: 725 SSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYG 784
Query: 113 KDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGG--SGNPNSNST 170
+ ++ +G STG G+ G +G ++ GQ S G SG S
Sbjct: 785 QHGSRQTSGFGQHGSGSSQSTGF-----GQYGSGSGQSAGFGQHGSGSGQSSGFGQHESR 839
Query: 171 STSTSAATAGAGSCGKSKEEKPGKSQ---SSRGAKRDKDAGKSRKDKHDLLQGHQNGSGS 227
S +S G+GS S + G S S G R S +H G +G G
Sbjct: 840 SHQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQ 899
Query: 228 QAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSA 270
G GFG + S + G+GS + G+ S+
Sbjct: 900 HGTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSS 942
Score = 45.4 bits (106), Expect = 4e-04
Identities = 46/212 (21%), Positives = 76/212 (35%), Gaps = 26/212 (12%)
Query: 63 KDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSA 122
++CGG +G+ ++ ++ S + + H+ S + S +S + +K
Sbjct: 364 QNCGGQWRTGSSQSSCCG---QYGSGGSQSCSNGQHEYGSCGRFSNSSSSNEFSK----C 416
Query: 123 ALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTST---------S 173
YG ST Q G +S Q V G STS+ S
Sbjct: 417 DQYGSGSSQSTSFEQH-----GTGLSQSSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGS 471
Query: 174 TSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGG 233
+S T+G G G + G Q G+ + G+ H + G +G G G
Sbjct: 472 SSGKTSGFGQHGSGSGQSSGFGQCGSGSGQSSGFGQ-----HGSVSGQSSGFGQHGSVSG 526
Query: 234 HLYGFGAKSNGGGASPFHCGGTGSGSVAAAGE 265
GFG + S + G+GS + G+
Sbjct: 527 QSSGFGQHESRSRQSSYGQHGSGSSQSSGYGQ 558
Score = 43.5 bits (101), Expect = 0.002
Identities = 51/221 (23%), Positives = 78/221 (35%), Gaps = 9/221 (4%)
Query: 59 SSNSKDCG-GPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDAN- 116
S +S+ G G SG+G +A + + Q S S S +S+ +
Sbjct: 799 SGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSGY 858
Query: 117 --KSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGG--SGNPNSNSTST 172
S G + S+ + G+ G +G +S GQ + G SG S S
Sbjct: 859 GQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHESRSH 918
Query: 173 STSAATAGAGSCGKSKEEKPGKSQSSR---GAKRDKDAGKSRKDKHDLLQGHQNGSGSQA 229
+S G+GS S + G S G R S +H G +G G
Sbjct: 919 QSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGFGQHGSGSGQSSGFGQHE 978
Query: 230 PSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSA 270
G GFG + S + G+GS + G+ S+
Sbjct: 979 SGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSS 1019
Score = 41.6 bits (96), Expect = 0.006
Identities = 40/144 (27%), Positives = 57/144 (39%), Gaps = 7/144 (4%)
Query: 136 RQEVQGRPGEATGMNSALGQSVSSGGSG---NPNSNSTSTSTSAATAGAGSCGKSKEEKP 192
RQ G+ G + +S GQ S SG + + ST +G+G +
Sbjct: 539 RQSSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGS 598
Query: 193 GKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASP-FH 251
G QSS + + +G+S +H G SG GFG +G S F
Sbjct: 599 GSGQSSGFGQHESRSGQSSYGQHS--SGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFG 656
Query: 252 CGGTGSGSVAAAGE-VSKSAPDSG 274
G+GSG + G+ VS S SG
Sbjct: 657 QYGSGSGQSSGFGQHVSGSGQSSG 680
Score = 40.8 bits (94), Expect = 0.010
Identities = 39/145 (26%), Positives = 59/145 (40%), Gaps = 17/145 (11%)
Query: 131 SSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEE 190
SS+GK G+ G +G +S GQ S GSG + S S ++G G G +
Sbjct: 471 SSSGKTSGF-GQHGSGSGQSSGFGQCGS--GSGQSSGFGQHGSVSGQSSGFGQHGSVSGQ 527
Query: 191 KPG----------KSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGA 240
G S G+ + +G + + Q+G GS +G YG G+
Sbjct: 528 SSGFGQHESRSRQSSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGS 587
Query: 241 KSNGGGASPFHCGGTGSGSVAAAGE 265
G +S F G+GSG + G+
Sbjct: 588 ----GQSSGFGQHGSGSGQSSGFGQ 608
Score = 40.4 bits (93), Expect = 0.013
Identities = 47/220 (21%), Positives = 77/220 (35%), Gaps = 29/220 (13%)
Query: 66 GGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALY 125
G SSG G + + + + Q + + + S +TS L S
Sbjct: 674 GSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSS---GQTSGFGQHELSSGQSS 730
Query: 126 GIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAA-------- 177
+ S + G+ G +G +S GQ S G + +S+ +S S+
Sbjct: 731 SFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQ 790
Query: 178 TAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYG 237
T+G G G + G Q G+ + G Q+GSGS G G
Sbjct: 791 TSGFGQHGSGSSQSTGFGQYGSGSGQSAGFG-------------QHGSGS-----GQSSG 832
Query: 238 FGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMG 277
FG + S + G+GS + G+ S+ + G
Sbjct: 833 FGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFG 872
Score = 39.7 bits (91), Expect = 0.022
Identities = 47/219 (21%), Positives = 76/219 (34%), Gaps = 31/219 (14%)
Query: 57 TSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDAN 116
+S + G SSG G + + + + + Q + + + S +T+
Sbjct: 971 SSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSS---GQTTGFGQ 1027
Query: 117 KSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQ--------SVSSGGSGNPNSN 168
S G + S + G+ G +G +S GQ S GSG+ S+
Sbjct: 1028 HRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYGQHGSGSSQSS 1087
Query: 169 STST--STSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSG 226
S S T+G G + +PG QSS + +G+S +G G
Sbjct: 1088 GYGQHGSNSGQTSGFG------QHRPGSGQSSGFGQYGSGSGQS------------SGFG 1129
Query: 227 SQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGE 265
G GF G S + GTGS + G+
Sbjct: 1130 QHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQ 1168
Score = 36.6 bits (83), Expect = 0.19
Identities = 53/239 (22%), Positives = 83/239 (34%), Gaps = 34/239 (14%)
Query: 60 SNSKDCGGP--ASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANK 117
SNS CG P ASS + G +F+ +Q+ G + + +
Sbjct: 283 SNSSGCGRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPE 342
Query: 118 SLPSAALYGIPEISS--TGKRQEVQGRPGEATGMNSALGQSVSSGGSGN----------- 164
S P + Y + G+ Q G+ + +S GQ SGGS +
Sbjct: 343 SNPCSQSYSQRGYGARENGQPQNCGGQWRTGSSQSSCCGQ-YGSGGSQSCSNGQHEYGSC 401
Query: 165 ---PNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRK--------- 212
NS+S++ + G+GS + E+ G S G +
Sbjct: 402 GRFSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQSSGFEQHVCGSGQTCGQHESTSS 461
Query: 213 -----DKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGG-ASPFHCGGTGSGSVAAAGE 265
D+H G +G G G GFG +G G +S F G+ SG + G+
Sbjct: 462 QSLGYDQHGSSSGKTSGFGQHGSGSGQSSGFGQCGSGSGQSSGFGQHGSVSGQSSGFGQ 520
Score = 32.7 bits (73), Expect = 2.7
Identities = 31/123 (25%), Positives = 43/123 (34%), Gaps = 15/123 (12%)
Query: 144 GEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGA--GSCGKSKEEKPGKSQSSRG- 200
G T A G S S G+ + T + + AG+ G G S E+ G + G
Sbjct: 2019 GSRTTGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGD 2078
Query: 201 AKRDKDAGKSRKDKHDLL------QGHQNGSGSQAPSG------GHLYGFGAKSNGGGAS 248
R +G + + GH S S+ SG GH YG +G S
Sbjct: 2079 TTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGS 2138
Query: 249 PFH 251
H
Sbjct: 2139 AIH 2141
Score = 32.0 bits (71), Expect = 4.7
Identities = 37/174 (21%), Positives = 64/174 (36%), Gaps = 14/174 (8%)
Query: 131 SSTGKRQ---EVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKS 187
S TGK + + R G+++ G S SSG + + + +TS +G+ + S
Sbjct: 1133 SGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSS 1192
Query: 188 KEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGA 247
+ QS+ + +G+S G G Q SG ++G ++G
Sbjct: 1193 GQHISDSGQSTGFGQYGSGSGQS--------TGLGQGESQQVESGSTVHGRQETTHGQTI 1244
Query: 248 SPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKTE 301
+ +G G G S NS E + SHR + + T+
Sbjct: 1245 NTTRHSQSGQGQSTQTGSRVTRRRRSSQSENS---DSEVHSKVSHRHSEHIHTQ 1295
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 50.1 bits (118), Expect = 2e-05
Identities = 103/536 (19%), Positives = 176/536 (32%), Gaps = 70/536 (13%)
Query: 46 QKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASV-----------QASAPQ 94
+K + ST +SSS S+D AT L G++ V +AS
Sbjct: 985 RKARASESTARSSSSESED-----EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAG 1039
Query: 95 GNSHKETS------KSKVKRSKTSKDANKSLP--SAALYGIPEISSTGKRQEVQGRPGEA 146
+S KE+S K + ++ SK SLP AAL + + +S + + +P +
Sbjct: 1040 ASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQP--S 1097
Query: 147 TGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKD 206
+G++SA+G P ++ STS A G +K KP + + K +
Sbjct: 1098 SGVDSAVGTL--------PATSPQSTSVQAK-------GTNKLRKPKLPEVQQATKAPES 1142
Query: 207 AGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEV 266
+ S ++G G Q H G +P + A + E
Sbjct: 1143 SDDSEDSSDSSSGSEEDGEGPQGAKSAHTL---------GPTPSRTETLVEETAAESSED 1193
Query: 267 SKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSLTPQILP 326
AP L+ M ++ + KL + P PQ
Sbjct: 1194 DVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAA 1253
Query: 327 SYFSPSS--SNIAAPVEQLLVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHE 384
SP + A+ R G + + + C G L
Sbjct: 1254 GMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQA 1313
Query: 385 TEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPR--------FCESPTSDLEMRGGRGRGK 436
+ VL + K V T + ++ W + +P S + + G G G
Sbjct: 1314 SVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG- 1372
Query: 437 RARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRRTPPN-------CAAED 489
A+ +P ++ ++ + ++K G K +GSL + G + P E
Sbjct: 1373 --GEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1430
Query: 490 IKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQ 545
S + K K K E K K+ T +P+ + K + +Q
Sbjct: 1431 GDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1486
Score = 33.1 bits (74), Expect = 2.1
Identities = 127/684 (18%), Positives = 232/684 (33%), Gaps = 114/684 (16%)
Query: 629 GAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSA 688
G P E S + + G+ KGL + ++PV ++ +
Sbjct: 685 GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQG--TAPV 742
Query: 689 ADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQ 748
G + +++AE D ++ ++ ++A S K+ PA A P
Sbjct: 743 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP-- 800
Query: 749 LIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKS-----PPLKPIQPKPTIMGEPITVNP 803
+ GTI + T QA +S PP++ Q + P +V
Sbjct: 801 -----------SAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Query: 804 ALVSL-----------KDKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASKDLPGH 852
++ +D E+ ++E + K K ++ + +K+ P
Sbjct: 850 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP-- 907
Query: 853 FLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLEC-STLVN 911
G + + + A+A K D++ S S S S E + + +
Sbjct: 908 ------------RKGAAPTPPGKTGPSAAQAGK----QDDSGSSSEESDSDGEAPAAVTS 951
Query: 912 GQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISS 971
Q PL + N S A ++PA + + + + S S D+I +
Sbjct: 952 AQVIKPPLIFVDPN--RSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPA 1009
Query: 972 KDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIK 1031
+ G + P H P +P A AG S S + +I
Sbjct: 1010 TQCLTPGIRTNVVT--------MPTAH---PRIAPK--------ASMAGASSSKESSRI- 1049
Query: 1032 KESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQS---VITQRHPALAQSLYYGQYAYGLY 1088
D +K++ SKK N ASL P Q+ V+ Q+ + Q + G+
Sbjct: 1050 ----SDGKKQEGPATQVSKK---NPASL-PLTQAALKVLAQKASEAQPPVARTQPSSGVD 1101
Query: 1089 MDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNM 1148
+L ATSP K K+ + + ++ ++ P E++ +
Sbjct: 1102 SAVGTLPATSPQSTSVQAK-------GTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS 1154
Query: 1149 PSATISKAPSTPEPNKNHSKLGPSVPNKTE--------ETGKSQLLSNHQQQLQADSFKA 1200
S + P+ K+ LGP+ P++TE E+ + +++ Q L
Sbjct: 1155 GSEEDGEG---PQGAKSAHTLGPT-PSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPG 1210
Query: 1201 KQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEEL 1260
N Q K ++ S V T K DPD + +P+ S +
Sbjct: 1211 LTPANSQASKATPKLDS------SPSVSSTLAAKDDPDGK----QEAKPQQAAGMLSPKT 1260
Query: 1261 DREKKLKEDSPRKT--PNKESGVP 1282
++ +P+K+ P K +G P
Sbjct: 1261 GGKEAASGTTPQKSRKPKKGAGNP 1284
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 50.1 bits (118), Expect = 2e-05
Identities = 103/536 (19%), Positives = 176/536 (32%), Gaps = 70/536 (13%)
Query: 46 QKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASV-----------QASAPQ 94
+K + ST +SSS S+D AT L G++ V +AS
Sbjct: 908 RKARASESTARSSSSESED-----EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAG 962
Query: 95 GNSHKETS------KSKVKRSKTSKDANKSLP--SAALYGIPEISSTGKRQEVQGRPGEA 146
+S KE+S K + ++ SK SLP AAL + + +S + + +P +
Sbjct: 963 ASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQP--S 1020
Query: 147 TGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKD 206
+G++SA+G P ++ STS A G +K KP + + K +
Sbjct: 1021 SGVDSAVGTL--------PATSPQSTSVQAK-------GTNKLRKPKLPEVQQATKAPES 1065
Query: 207 AGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEV 266
+ S ++G G Q H G +P + A + E
Sbjct: 1066 SDDSEDSSDSSSGSEEDGEGPQGAKSAHTL---------GPTPSRTETLVEETAAESSED 1116
Query: 267 SKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSLTPQILP 326
AP L+ M ++ + KL + P PQ
Sbjct: 1117 DVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAA 1176
Query: 327 SYFSPSS--SNIAAPVEQLLVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHE 384
SP + A+ R G + + + C G L
Sbjct: 1177 GMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQA 1236
Query: 385 TEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPR--------FCESPTSDLEMRGGRGRGK 436
+ VL + K V T + ++ W + +P S + + G G G
Sbjct: 1237 SVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG- 1295
Query: 437 RARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRRTPPN-------CAAED 489
A+ +P ++ ++ + ++K G K +GSL + G + P E
Sbjct: 1296 --GEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1353
Query: 490 IKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQ 545
S + K K K E K K+ T +P+ + K + +Q
Sbjct: 1354 GDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1409
Score = 33.1 bits (74), Expect = 2.1
Identities = 127/684 (18%), Positives = 232/684 (33%), Gaps = 114/684 (16%)
Query: 629 GAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSA 688
G P E S + + G+ KGL + ++PV ++ +
Sbjct: 608 GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQG--TAPV 665
Query: 689 ADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQ 748
G + +++AE D ++ ++ ++A S K+ PA A P
Sbjct: 666 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP-- 723
Query: 749 LIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKS-----PPLKPIQPKPTIMGEPITVNP 803
+ GTI + T QA +S PP++ Q + P +V
Sbjct: 724 -----------SAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 772
Query: 804 ALVSL-----------KDKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASKDLPGH 852
++ +D E+ ++E + K K ++ + +K+ P
Sbjct: 773 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP-- 830
Query: 853 FLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLEC-STLVN 911
G + + + A+A K D++ S S S S E + + +
Sbjct: 831 ------------RKGAAPTPPGKTGPSAAQAGK----QDDSGSSSEESDSDGEAPAAVTS 874
Query: 912 GQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISS 971
Q PL + N S A ++PA + + + + S S D+I +
Sbjct: 875 AQVIKPPLIFVDPN--RSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPA 932
Query: 972 KDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIK 1031
+ G + P H P +P A AG S S + +I
Sbjct: 933 TQCLTPGIRTNVVT--------MPTAH---PRIAPK--------ASMAGASSSKESSRI- 972
Query: 1032 KESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQS---VITQRHPALAQSLYYGQYAYGLY 1088
D +K++ SKK N ASL P Q+ V+ Q+ + Q + G+
Sbjct: 973 ----SDGKKQEGPATQVSKK---NPASL-PLTQAALKVLAQKASEAQPPVARTQPSSGVD 1024
Query: 1089 MDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNM 1148
+L ATSP K K+ + + ++ ++ P E++ +
Sbjct: 1025 SAVGTLPATSPQSTSVQAK-------GTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS 1077
Query: 1149 PSATISKAPSTPEPNKNHSKLGPSVPNKTE--------ETGKSQLLSNHQQQLQADSFKA 1200
S + P+ K+ LGP+ P++TE E+ + +++ Q L
Sbjct: 1078 GSEEDGEG---PQGAKSAHTLGPT-PSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPG 1133
Query: 1201 KQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEEL 1260
N Q K ++ S V T K DPD + +P+ S +
Sbjct: 1134 LTPANSQASKATPKLDS------SPSVSSTLAAKDDPDGK----QEAKPQQAAGMLSPKT 1183
Query: 1261 DREKKLKEDSPRKT--PNKESGVP 1282
++ +P+K+ P K +G P
Sbjct: 1184 GGKEAASGTTPQKSRKPKKGAGNP 1207
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 49.3 bits (116), Expect = 3e-05
Identities = 103/536 (19%), Positives = 176/536 (32%), Gaps = 69/536 (12%)
Query: 46 QKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASV-----------QASAPQ 94
+K + ST +SSS S+D AT L G++ V +AS
Sbjct: 908 RKARASESTARSSSSESED-----EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAG 962
Query: 95 GNSHKETS------KSKVKRSKTSKDANKSLP--SAALYGIPEISSTGKRQEVQGRPGEA 146
+S KE+S K + ++ SK SLP AAL + + +S + + +P +
Sbjct: 963 ASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQP--S 1020
Query: 147 TGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKD 206
+G++SA+G P ++ STS A G +K KP + + K +
Sbjct: 1021 SGVDSAVGTL--------PATSPQSTSVQAK-------GTNKLRKPKLPEVQQATKAPES 1065
Query: 207 AGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEV 266
+ S ++G G Q H G +P + A + E
Sbjct: 1066 SDDSEDSSDSSSGSEEDGEGPQGAKSAHTL--------VGPTPSRTETLVEETAAESSED 1117
Query: 267 SKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSLTPQILP 326
AP L+ M ++ + KL + P PQ
Sbjct: 1118 DVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAA 1177
Query: 327 SYFSPSS--SNIAAPVEQLLVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHE 384
SP + A+ R G + + + C G L
Sbjct: 1178 GMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQA 1237
Query: 385 TEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPR--------FCESPTSDLEMRGGRGRGK 436
+ VL + K V T + ++ W + +P S + + G G G
Sbjct: 1238 SVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG- 1296
Query: 437 RARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRRTPPN-------CAAED 489
A+ +P ++ ++ + ++K G K +GSL + G + P E
Sbjct: 1297 --GEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1354
Query: 490 IKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQ 545
S + K K K E K K+ T +P+ + K + +Q
Sbjct: 1355 GDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1410
Score = 33.5 bits (75), Expect = 1.6
Identities = 126/684 (18%), Positives = 232/684 (33%), Gaps = 113/684 (16%)
Query: 629 GAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSA 688
G P E S + + G+ KGL + ++PV ++ +
Sbjct: 608 GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQG--TAPV 665
Query: 689 ADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQ 748
G + +++AE D ++ ++ ++A S K+ PA A P
Sbjct: 666 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP-- 723
Query: 749 LIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKS-----PPLKPIQPKPTIMGEPITVNP 803
+ GTI + T QA +S PP++ Q + P +V
Sbjct: 724 -----------SAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 772
Query: 804 ALVSL-----------KDKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASKDLPGH 852
++ +D E+ ++E + K K ++ + +K+ P
Sbjct: 773 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP-- 830
Query: 853 FLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLEC-STLVN 911
G + + + A+A K D++ S S S S E + + +
Sbjct: 831 ------------RKGAAPTPPGKTGPSAAQAGK----QDDSGSSSEESDSDGEAPAAVTS 874
Query: 912 GQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISS 971
Q PL + N S A ++PA + + + + S S D+I +
Sbjct: 875 AQVIKPPLIFVDPN--RSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPA 932
Query: 972 KDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIK 1031
+ G + P H P +P A AG S S + +I
Sbjct: 933 TQCLTPGIRTNVVT--------MPTAH---PRIAPK--------ASMAGASSSKESSRI- 972
Query: 1032 KESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQS---VITQRHPALAQSLYYGQYAYGLY 1088
D +K++ SKK N ASL P Q+ V+ Q+ + Q + G+
Sbjct: 973 ----SDGKKQEGPATQVSKK---NPASL-PLTQAALKVLAQKASEAQPPVARTQPSSGVD 1024
Query: 1089 MDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNM 1148
+L ATSP K K+ + + ++ ++ P E++ +
Sbjct: 1025 SAVGTLPATSPQSTSVQAK-------GTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS 1077
Query: 1149 PSATISKAPSTPEPNKNHSKLGPSVPNKTE--------ETGKSQLLSNHQQQLQADSFKA 1200
S + P + H+ +GP+ P++TE E+ + +++ Q L
Sbjct: 1078 GSEEDGEGPQGAK--SAHTLVGPT-PSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPG 1134
Query: 1201 KQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEEL 1260
N Q K ++ S V T K DPD + +P+ S +
Sbjct: 1135 LTPANSQASKATPKLDS------SPSVSSTLAAKDDPDGK----QEAKPQQAAGMLSPKT 1184
Query: 1261 DREKKLKEDSPRKT--PNKESGVP 1282
++ +P+K+ P K +G P
Sbjct: 1185 GGKEAASGTTPQKSRKPKKGAGNP 1208
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 48.9 bits (115), Expect = 4e-05
Identities = 53/239 (22%), Positives = 94/239 (39%), Gaps = 18/239 (7%)
Query: 821 DKEGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIK 880
D S D+ K + SK S D + N ++ S+S +S +S
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665
Query: 881 AEADKVYTFTDNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPA-Y 939
+++ +D++ S ++S S+ + N +ESS + SS +
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSD-------------SSNSSESSDSSDSSDSDS 712
Query: 940 SDISDAADDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHS 999
SD SD+++ SDS S S +S SD +S DS SS ++ SS +S + S
Sbjct: 713 SDSSDSSNSNSSDSDS----SNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768
Query: 1000 YDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSAS 1058
S S + + NS + +S ++ D ++ DS + + +S
Sbjct: 769 DSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS 827
Score = 47.0 bits (110), Expect = 1e-04
Identities = 47/235 (20%), Positives = 91/235 (38%), Gaps = 8/235 (3%)
Query: 831 KMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFT 890
K D+ GK + S S D N ++ + S+S +S +S +D + +
Sbjct: 539 KSDSGKGKSDSSDSDSSDSS--------NSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDS 590
Query: 891 DNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGG 950
++ S ++S S+ + + + + ++S + + S + SD SD+
Sbjct: 591 SDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDS 650
Query: 951 SDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMH 1010
SD+ S +S+ SD S DS SS ++ SS +S S S S
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDS 710
Query: 1011 PGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQS 1065
+ ++ ++ S +S + + D ++ DS +S S + S
Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSS 765
Score = 45.8 bits (107), Expect = 3e-04
Identities = 50/270 (18%), Positives = 102/270 (37%), Gaps = 5/270 (1%)
Query: 13 DPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSG 72
D N+ D+ D+ D + + D +D ++S+ ++ SS+S D + S
Sbjct: 644 DSNSSDSSDNSDSSDSSNSSNSSD-SSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESS 702
Query: 73 AGATAALADGLKFA-SVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEIS 131
+ ++ +D + S +++ +S + S S S D++ S S+ + S
Sbjct: 703 DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSS 762
Query: 132 STGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEK 191
++ + + NS+ S+ + +SNS+ +S S+ ++ + S
Sbjct: 763 NSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSN 822
Query: 192 PGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGA--KSNGGGASP 249
S +S + D D D G + S +++ S + SN +S
Sbjct: 823 SSDSSNSSDSS-DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSD 881
Query: 250 FHCGGTGSGSVAAAGEVSKSAPDSGLMGNS 279
S S ++ + S DS NS
Sbjct: 882 SSDSNESSNSSDSSDSSNSSDSDSSDSSNS 911
Score = 45.8 bits (107), Expect = 3e-04
Identities = 53/251 (21%), Positives = 94/251 (37%), Gaps = 8/251 (3%)
Query: 821 DKEGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKN--EGLANGLSESQESRMAS 878
D S D+ S D D N N + ++ S+S +S +S
Sbjct: 682 DSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSS 741
Query: 879 IKAEADKVYTFTDNAPSPSIGSASRLECSTLVNGQAPMAPLHVL--TQNGAESSAAKTSS 936
+++ +D++ S ++S S+ + + + + N ++SS + SS
Sbjct: 742 DSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSS 801
Query: 937 PAY--SDISDAADDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTAQSSQLKESHS 994
+ SD SD++D SDS + S +S SD +S DS SS + S S S
Sbjct: 802 DSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861
Query: 995 PYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDH 1054
+S D S + + N S + D++ D + DS +
Sbjct: 862 S--NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN 919
Query: 1055 NSASLQPQHQS 1065
+S S + + S
Sbjct: 920 SSDSSESSNSS 930
Score = 45.4 bits (106), Expect = 4e-04
Identities = 48/225 (21%), Positives = 85/225 (37%), Gaps = 2/225 (0%)
Query: 841 DSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGS 900
DS +S D + NE ++ S+S +S +S +D + + S S S
Sbjct: 866 DSSDSSDSSNSSDSSDSSDSNE--SSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDS 923
Query: 901 ASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRS 960
+ S N + + +S+ ++S S+ SD++D SDS S
Sbjct: 924 SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS 983
Query: 961 KASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAG 1020
+S SD S DS +SS ++ SS +S + S S S + +
Sbjct: 984 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSS 1043
Query: 1021 NSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQS 1065
+S + S + ++ D ++ DS +S S + S
Sbjct: 1044 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088
Score = 44.7 bits (104), Expect = 7e-04
Identities = 43/265 (16%), Positives = 93/265 (35%), Gaps = 12/265 (4%)
Query: 15 NTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAG 74
N+ D+ DS D D+D ++S+ +++SS+S D +
Sbjct: 805 NSSDSSDSSD-----------SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS 853
Query: 75 ATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEISSTG 134
++ +D + S+ NS + S S S D++ S S+ + S++
Sbjct: 854 DSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSD-SDSSDSSNSS 912
Query: 135 KRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGK 194
+ + NS+ + S + + +S+S+ +S S+ ++ + S +
Sbjct: 913 DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972
Query: 195 SQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGG 254
S S + D+ S + S + S + + + +
Sbjct: 973 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032
Query: 255 TGSGSVAAAGEVSKSAPDSGLMGNS 279
+ S ++ S + DS NS
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNS 1057
Score = 43.5 bits (101), Expect = 0.002
Identities = 42/259 (16%), Positives = 91/259 (35%), Gaps = 15/259 (5%)
Query: 15 NTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAG 74
N+ D+ DS D + +D + +NS+ ++ SSNS D + S
Sbjct: 763 NSSDSSDSSDSSD----------SSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS 812
Query: 75 ATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEISSTG 134
+ ++ +D + S+ +S + S S D++ S S + SS
Sbjct: 813 SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS-----SNSSDS 867
Query: 135 KRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGK 194
+++ + + S SS S + NS+ + +S S+ ++ + S +
Sbjct: 868 SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927
Query: 195 SQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGG 254
+ S D D D + + S + + + + ++
Sbjct: 928 NSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSD 987
Query: 255 TGSGSVAAAGEVSKSAPDS 273
+ S ++ S ++ DS
Sbjct: 988 SSDSSDSSDSSDSSNSSDS 1006
Score = 43.1 bits (100), Expect = 0.002
Identities = 44/265 (16%), Positives = 93/265 (35%), Gaps = 8/265 (3%)
Query: 15 NTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAG 74
N+ D+ DS D + D+D ++S+ ++ SSNS D + S
Sbjct: 837 NSSDSSDSSDSSD--------GSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888
Query: 75 ATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEISSTG 134
+ ++ + +S S+ NS + S S S +++ + S+ + S +
Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS 948
Query: 135 KRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGK 194
+ NS+ +S S + +++S S+ +S ++ + S S
Sbjct: 949 DSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008
Query: 195 SQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGG 254
S S + D+ S + + S + S + ++ +
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1068
Query: 255 TGSGSVAAAGEVSKSAPDSGLMGNS 279
+ S ++ S + DS NS
Sbjct: 1069 SSDSSDSSDSSDSSESSDSSDSSNS 1093
Score = 42.4 bits (98), Expect = 0.003
Identities = 53/284 (18%), Positives = 103/284 (36%), Gaps = 12/284 (4%)
Query: 15 NTVDTYDSGDDWEIGVGNLIIDLD-------ADLEKDRQKFEMNNSTTTTSSSNSKDCGG 67
N+ D+ DS D E + D +D + +NS+ ++ SSNS D
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934
Query: 68 PASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGI 127
+ S + ++ + +S +++ ++ ++S S S S +++ S S+
Sbjct: 935 SSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDS 994
Query: 128 PEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKS 187
+ S + + + NS+ S +S S N + +S S+ +S ++ + S S
Sbjct: 995 SDSSDSSNSSDSSDSSDSSDSSNSS--DSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 188 KEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGA 247
S S + D+ S D D + + S + S+ +
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111
Query: 248 SPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEES 291
S S S ++ S + DS NS E +S
Sbjct: 1112 SDSSDSSDSSNSSDSSD--SSDSSDSSDSSNSSDSSDSSESSDS 1153
Score = 41.6 bits (96), Expect = 0.006
Identities = 36/212 (16%), Positives = 71/212 (33%)
Query: 18 DTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAGATA 77
D+ DS D + + D + N+S ++ SS +S SS + ++
Sbjct: 990 DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSS 1049
Query: 78 ALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQ 137
+D + S+ +S + S S S D++ S S+ + S +
Sbjct: 1050 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSS 1109
Query: 138 EVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQS 197
+ + NS+ S + +SNS+ +S S+ ++ + S + S
Sbjct: 1110 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSS 1169
Query: 198 SRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQA 229
D D D + S +
Sbjct: 1170 DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1201
Score = 41.6 bits (96), Expect = 0.006
Identities = 50/223 (22%), Positives = 90/223 (40%), Gaps = 10/223 (4%)
Query: 841 DSKGASKDLPGHFLKDHLNKNEGL-ANGLSESQESRMASIKAEADKVYTFTDNAPSPSIG 899
DS +S D N ++ ++ S S +S +S +++ +D++ S +
Sbjct: 999 DSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSS 1058
Query: 900 SASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDG----GSDSRS 955
+S S+ + + + + + +ESS + SS + SD SD++D SDS
Sbjct: 1059 DSSDSSDSSDSSDSSDSSD----SSDSSESSDSSDSSNS-SDSSDSSDSSDSSDSSDSSD 1113
Query: 956 EGMRSKASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVG 1015
S +S+ SD S DS SS ++ SS ES S S S
Sbjct: 1114 SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSD 1173
Query: 1016 APAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSAS 1058
+ + NS + +S + ++ D ++ DS +S S
Sbjct: 1174 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1216
Score = 41.2 bits (95), Expect = 0.008
Identities = 52/286 (18%), Positives = 100/286 (34%), Gaps = 13/286 (4%)
Query: 13 DPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSG 72
D ++ T D+ + G GN D D K + + +S S+S D + S
Sbjct: 512 DDDSDSTSDTNNSDSNGNGNNGND-------DNDKSDSGKGKSDSSDSDSSDSSNSSDSS 564
Query: 73 AGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEISS 132
+ + +D + +S + ++ S S S D++ S S+ + S
Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624
Query: 133 TGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNS----NSTSTSTSAATAGAGSCGKS- 187
+ E ++ +S S SS S + +S NS+ +S S+ ++ + S S
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSS 684
Query: 188 -KEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGG 246
+ S SS ++ + S D D + S S + S+
Sbjct: 685 NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744
Query: 247 ASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESH 292
S + S + + S S+ S +S + + S+
Sbjct: 745 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSN 790
Score = 40.0 bits (92), Expect = 0.017
Identities = 38/204 (18%), Positives = 79/204 (38%), Gaps = 3/204 (1%)
Query: 15 NTVDTYDSGDDWEIGVGNLIIDLD--ADLEKDRQKFEMNNSTTTTSSSNSKDCGGPA-SS 71
N+ D+ DS D + + D +D + ++S+ ++ SSNS D + SS
Sbjct: 1092 NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESS 1151
Query: 72 GAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEIS 131
+ ++ +D + S+ +S + S S S D++ S S+ + S
Sbjct: 1152 DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1211
Query: 132 STGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEK 191
+ + + +S S + +SNS+ +S S+ ++ + S + +
Sbjct: 1212 DSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDS 1271
Query: 192 PGKSQSSRGAKRDKDAGKSRKDKH 215
KS + D D+ D +
Sbjct: 1272 QSKSGNGNNNGSDSDSDSEGSDSN 1295
Score = 37.4 bits (85), Expect = 0.11
Identities = 56/291 (19%), Positives = 99/291 (34%), Gaps = 12/291 (4%)
Query: 3 VNISTAGKGVDP-NTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSN 61
VNI G+ +P N V ++G D G D D +K Q + N+S + + +
Sbjct: 421 VNIEGPGQKSEPGNKVGHSNTGSDSNSD-GYDSYDFD---DKSMQGDDPNSSDESNGNDD 476
Query: 62 SKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPS 121
+ SS G + +D K + + S S S ++ + N
Sbjct: 477 ANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDD 536
Query: 122 AALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGA 181
+ S +GK + + NS+ S S + NS+S S S+ + ++ +
Sbjct: 537 N------DKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDS 590
Query: 182 GSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPS-GGHLYGFGA 240
S S S + D+ S K D + + S S + S +
Sbjct: 591 SDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDS 650
Query: 241 KSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEES 291
N + + + S ++ S S+ DS +S ES
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSES 701
Score = 36.6 bits (83), Expect = 0.19
Identities = 98/634 (15%), Positives = 212/634 (33%), Gaps = 32/634 (5%)
Query: 438 ARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRRTPPNCAAEDIKASPSST 497
+ S+ ++ S++S + + + ++ S N+S + + D S S+
Sbjct: 660 SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSS 719
Query: 498 NKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVLIDCPH 557
N + +SS N ++S ++ + + D SS
Sbjct: 720 NSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDS 779
Query: 558 PNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEEGL----------SNVAL 607
N + N + D N + S+ SD S+ +
Sbjct: 780 SNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS 839
Query: 608 ECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLN 667
+ S+ S S D + S + + + S+ S ++ +S N
Sbjct: 840 DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSN 899
Query: 668 NELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDK 727
+ ++ SN + + DS +++D S ++ + D N D ++N
Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDSSESSNSS--DNSNSSDSSNSSDSSDSSDSSNSSDSS 957
Query: 728 NLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSPPLKP 787
N S ++ + + + ++ ++ ++ + S ++ + S
Sbjct: 958 NSSDSSNSSDSSDSNSSD---------SSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008
Query: 788 IQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASK 847
+ N + S + ++ + DS +S
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1068
Query: 848 DLPGHFLKDHLNKNEGL----ANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASR 903
D + +E ++ S+S +S +S +++ +D++ S + +S
Sbjct: 1069 SSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128
Query: 904 LECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDG-GSDSRSEGMRSKA 962
S+ + + + + + +ESS + SS + SD SD++D SDS S +
Sbjct: 1129 SSDSSDSSDSSNSSD----SSDSSESSDSSDSSDS-SDSSDSSDSSDSSDSSDSSNSSDS 1183
Query: 963 SSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSY-MHPGQVGAPAAGN 1021
S SD S DS SS ++ SS +S S S S + + ++ +
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDS 1243
Query: 1022 SGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHN 1055
S S+ S+ D ++ DS+ N
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGN 1277
Score = 33.5 bits (75), Expect = 1.6
Identities = 31/134 (23%), Positives = 51/134 (38%), Gaps = 1/134 (0%)
Query: 926 GAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTAQ 985
GAE + ++S + S+ + G+D + K S S S DS SS ++
Sbjct: 509 GAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSD 568
Query: 986 SSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAE 1045
S + S S D S S + ++ +S S+ S+ K D ++
Sbjct: 569 SDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSK 628
Query: 1046 -QLDSKKVDHNSAS 1058
+ DS D S S
Sbjct: 629 SESDSSDSDSKSDS 642
Score = 32.7 bits (73), Expect = 2.7
Identities = 33/135 (24%), Positives = 52/135 (38%), Gaps = 13/135 (9%)
Query: 925 NGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTA 984
NG + + S SD SD +D S + S+ S S SD SS DS S+ +
Sbjct: 532 NGNDDNDKSDSGKGKSDSSD-SDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDS 590
Query: 985 QSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKD-K 1043
S +S + S + ++ +S S+ +SE D+ D K
Sbjct: 591 SDSDSSDSS-----------NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSK 639
Query: 1044 AEQLDSKKVDHNSAS 1058
++ DS D + S
Sbjct: 640 SDSSDSNSSDSSDNS 654
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 48.5 bits (114), Expect = 5e-05
Identities = 50/151 (33%), Positives = 67/151 (44%), Gaps = 25/151 (16%)
Query: 701 EAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPT---PPQLIAIPTATF 757
E E DKK D+EKGKK + K +K K K APAP PP+ +A+P F
Sbjct: 612 EKEKHKDKKK--DREKGKKDKD-KREKEKVKDKGREDKMKAPAPPLVLPPKELALPL--F 666
Query: 758 TTTTTGTIPG-LPSLTTTVVQATPKSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEK 816
+ T +P LPSL + P K + K + + KDKK+K+K
Sbjct: 667 SPATASRVPAMLPSLLPVL--------PEKLFEEKEKVKEKE--------KKKDKKEKKK 710
Query: 817 RKLKDKEGKETGSPKMDAKLGKLEDSKGASK 847
+K K+KE KE K + K E K K
Sbjct: 711 KKEKEKEKKEKEREKEKREREKREKEKEKHK 741
Score = 34.3 bits (77), Expect = 0.94
Identities = 33/114 (28%), Positives = 44/114 (38%), Gaps = 17/114 (14%)
Query: 707 DKKNLGDKEKGKKATNC--------KTDKNLSKLKSAR----PIAPAPAPTPPQLIAIPT 754
+KK +KEK KK K +K K K + P+A AP+P P+L
Sbjct: 707 EKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVG 766
Query: 755 ATFTTTTTGTIPGLPSLTTTVVQATPKSPPLKPIQPKPTIMGEPITVNPALVSL 808
A + P Q PK+PP P P P+ V+PA V L
Sbjct: 767 AGQDKIVISKVVPAPEAKPAPSQNRPKTPP-----PAPAPAPGPMLVSPAPVPL 815
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 47.8 bits (112), Expect = 8e-05
Identities = 56/246 (22%), Positives = 92/246 (37%), Gaps = 26/246 (10%)
Query: 582 ENKLEFEPDSEDKISD-CEEGLSNVALECSEPSTSVSAYDQLKA--------PASPGAGN 632
+N+ + +P + + D GL N + + P TS + ++++ P +P
Sbjct: 71 KNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSL 130
Query: 633 PPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGS 692
PP + K ++ + + K + K+ + + + T +++ SA D +
Sbjct: 131 PPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTS--AKETQSIEKTSAKDLA 188
Query: 693 -----LAAEMPKLEAE----GLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPA 743
LA PK E L K + A+ + + +KSA PA
Sbjct: 189 PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 248
Query: 744 PTP----PQLIAIPTATFTTTTTGTIPGLPSLTTTVVQA--TPKSPPLKPIQPKPTIMGE 797
PT P P T T T P P+ TTT A T KS P P +P PT +
Sbjct: 249 PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKK 308
Query: 798 PITVNP 803
P P
Sbjct: 309 PAPTTP 314
Score = 42.7 bits (99), Expect = 0.003
Identities = 50/193 (25%), Positives = 61/193 (31%), Gaps = 16/193 (8%)
Query: 612 PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELN 671
P+T+ SA K PA + P TPK + P + + KK
Sbjct: 390 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 449
Query: 672 NLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSK 731
P T + A PK A KE T K
Sbjct: 450 PAP-----TTPKEPAPTTTKKPAPTTPKEPAPTT-------PKETAPTTPKKLTPTTPEK 497
Query: 732 LKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQP 790
L P PAPT P+ +A T T TT P P+ TPK P P P +P
Sbjct: 498 LAPTTP--EKPAPTTPEELAPTTPEEPTPTTPEEPA-PTTPKAAAPNTPKEPAPTTPKEP 554
Query: 791 KPTIMGEPITVNP 803
PT EP P
Sbjct: 555 APTTPKEPAPTTP 567
Score = 37.7 bits (86), Expect = 0.085
Identities = 71/317 (22%), Positives = 98/317 (30%), Gaps = 27/317 (8%)
Query: 509 DLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVLIDCPHPNCNK------ 562
D S + K K+ RT + TP P + LD G D NK
Sbjct: 58 DYESFCAEVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK 117
Query: 563 --KYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEEGLSNVALECSEPSTSVSAYD 620
K IN ++ E L ++ + + + + E +TS
Sbjct: 118 ITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 177
Query: 621 QLK-------APASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNL 673
++ AP S P TPK E + GP + + K+
Sbjct: 178 SIEKTSAKDLAPTSKVLAKP--TPKA--ETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233
Query: 674 PVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLK 733
P A + +A E K+ K T K + + K
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK-EPAPTTTK 292
Query: 734 SARPIAPAPAPTPPQLIA-----IPTATFTTTTTGTIPGLPSLTT-TVVQATPKSP-PLK 786
SA PAPT P+ A P T T T P P+ TT TPK P P
Sbjct: 293 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 352
Query: 787 PIQPKPTIMGEPITVNP 803
P +P PT EP P
Sbjct: 353 PKKPAPTTPKEPAPTTP 369
Score = 37.0 bits (84), Expect = 0.14
Identities = 28/81 (34%), Positives = 32/81 (39%), Gaps = 13/81 (16%)
Query: 733 KSARPIAPA-PAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTT---------VVQATPKS 782
K P P PAPT P+ P T T + T P P+ TTT T KS
Sbjct: 354 KKPAPTTPKEPAPTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 410
Query: 783 PPLKPIQPKPTIMGEPITVNP 803
P P +P PT EP P
Sbjct: 411 APTTPKEPSPTTTKEPAPTTP 431
Score = 33.5 bits (75), Expect = 1.6
Identities = 74/321 (23%), Positives = 101/321 (31%), Gaps = 38/321 (11%)
Query: 493 SPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVL 552
SP++T + P E + + KP T PTTP+ TT ++P
Sbjct: 419 SPTTTKEPAPTTPKE---PAPTTPKKPAPT--TPKEPAPTTPKEPAPTTTKKPAPTTPKE 473
Query: 553 IDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCE-EGLSNVALECSE 611
P P K+ + L P + P + +K + E L+ E
Sbjct: 474 ---PAPTTPKETAPTTPKK-------LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPT 523
Query: 612 PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELN 671
P+T + AP +P A P TPK P + + K+
Sbjct: 524 PTTP-----EEPAPTTPKAA-APNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKG 577
Query: 672 NLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSK 731
P A A LA K DK KG T K +
Sbjct: 578 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP-APTTPKGTAPTTPKEPAPTTP 636
Query: 732 LKSARPIAPA---------PAPTPPQLIA----IPTATFTTTTTGTIPGLPSLTTTVVQA 778
K P P PAPT P+ A PT T T+T + P+
Sbjct: 637 -KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 695
Query: 779 TPKSP-PLKPIQPKPTIMGEP 798
TPK P P P +P PT P
Sbjct: 696 TPKEPAPTTPKKPAPTTPETP 716
Score = 33.1 bits (74), Expect = 2.1
Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 4/63 (6%)
Query: 742 PAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQPKPTIMGEPIT 800
P+PT P+ A PT T + TT P TT TPK P P +P PT EP
Sbjct: 380 PSPTTPKEPA-PTTTKSAPTTTKEPA--PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 436
Query: 801 VNP 803
P
Sbjct: 437 TTP 439
Score = 33.1 bits (74), Expect = 2.1
Identities = 37/158 (23%), Positives = 53/158 (33%), Gaps = 24/158 (15%)
Query: 714 KEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTT 773
K+ K T K + S +P P T P P T T P P TT
Sbjct: 661 KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTT 720
Query: 774 TVV-----------------QATPK---SPPLKPIQPKPTIMGEPITVNPAL----VSLK 809
+ V ++TP+ P K ++ P G P T PA ++
Sbjct: 721 SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTT 780
Query: 810 DKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASK 847
K K +R L+ T +PKM + + SK
Sbjct: 781 AKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESK 818
Score = 32.0 bits (71), Expect = 4.7
Identities = 32/98 (32%), Positives = 38/98 (38%), Gaps = 8/98 (8%)
Query: 742 PAPTPPQLIA----IPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQPKPTIM- 795
PAPT P+ A PT T T+T P+ TPK P P P +P PT
Sbjct: 586 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 645
Query: 796 -GEPITV-NPALVSLKDKKKKEKRKLKDKEGKETGSPK 831
P T+ PA + K KE K T S K
Sbjct: 646 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 683
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 47.8 bits (112), Expect = 8e-05
Identities = 56/246 (22%), Positives = 92/246 (37%), Gaps = 26/246 (10%)
Query: 582 ENKLEFEPDSEDKISD-CEEGLSNVALECSEPSTSVSAYDQLKA--------PASPGAGN 632
+N+ + +P + + D GL N + + P TS + ++++ P +P
Sbjct: 112 KNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSL 171
Query: 633 PPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGS 692
PP + K ++ + + K + K+ + + + T +++ SA D +
Sbjct: 172 PPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTS--AKETQSIEKTSAKDLA 229
Query: 693 -----LAAEMPKLEAE----GLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPA 743
LA PK E L K + A+ + + +KSA PA
Sbjct: 230 PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 289
Query: 744 PTP----PQLIAIPTATFTTTTTGTIPGLPSLTTTVVQA--TPKSPPLKPIQPKPTIMGE 797
PT P P T T T P P+ TTT A T KS P P +P PT +
Sbjct: 290 PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKK 349
Query: 798 PITVNP 803
P P
Sbjct: 350 PAPTTP 355
Score = 42.7 bits (99), Expect = 0.003
Identities = 50/193 (25%), Positives = 61/193 (31%), Gaps = 16/193 (8%)
Query: 612 PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELN 671
P+T+ SA K PA + P TPK + P + + KK
Sbjct: 431 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKE 490
Query: 672 NLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSK 731
P T + A PK A KE T K
Sbjct: 491 PAP-----TTPKEPAPTTTKKPAPTTPKEPAPTT-------PKETAPTTPKKLTPTTPEK 538
Query: 732 LKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQP 790
L P PAPT P+ +A T T TT P P+ TPK P P P +P
Sbjct: 539 LAPTTP--EKPAPTTPEELAPTTPEEPTPTTPEEPA-PTTPKAAAPNTPKEPAPTTPKEP 595
Query: 791 KPTIMGEPITVNP 803
PT EP P
Sbjct: 596 APTTPKEPAPTTP 608
Score = 37.7 bits (86), Expect = 0.085
Identities = 71/317 (22%), Positives = 98/317 (30%), Gaps = 27/317 (8%)
Query: 509 DLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVLIDCPHPNCNK------ 562
D S + K K+ RT + TP P + LD G D NK
Sbjct: 99 DYESFCAEVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK 158
Query: 563 --KYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEEGLSNVALECSEPSTSVSAYD 620
K IN ++ E L ++ + + + + E +TS
Sbjct: 159 ITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 218
Query: 621 QLK-------APASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNL 673
++ AP S P TPK E + GP + + K+
Sbjct: 219 SIEKTSAKDLAPTSKVLAKP--TPKA--ETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274
Query: 674 PVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLK 733
P A + +A E K+ K T K + + K
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK-EPAPTTTK 333
Query: 734 SARPIAPAPAPTPPQLIA-----IPTATFTTTTTGTIPGLPSLTT-TVVQATPKSP-PLK 786
SA PAPT P+ A P T T T P P+ TT TPK P P
Sbjct: 334 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 393
Query: 787 PIQPKPTIMGEPITVNP 803
P +P PT EP P
Sbjct: 394 PKKPAPTTPKEPAPTTP 410
Score = 37.0 bits (84), Expect = 0.14
Identities = 28/81 (34%), Positives = 32/81 (39%), Gaps = 13/81 (16%)
Query: 733 KSARPIAPA-PAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTT---------VVQATPKS 782
K P P PAPT P+ P T T + T P P+ TTT T KS
Sbjct: 395 KKPAPTTPKEPAPTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 451
Query: 783 PPLKPIQPKPTIMGEPITVNP 803
P P +P PT EP P
Sbjct: 452 APTTPKEPSPTTTKEPAPTTP 472
Score = 33.5 bits (75), Expect = 1.6
Identities = 74/321 (23%), Positives = 101/321 (31%), Gaps = 38/321 (11%)
Query: 493 SPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVL 552
SP++T + P E + + KP T PTTP+ TT ++P
Sbjct: 460 SPTTTKEPAPTTPKE---PAPTTPKKPAPT--TPKEPAPTTPKEPAPTTTKKPAPTTPKE 514
Query: 553 IDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCE-EGLSNVALECSE 611
P P K+ + L P + P + +K + E L+ E
Sbjct: 515 ---PAPTTPKETAPTTPKK-------LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPT 564
Query: 612 PSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELN 671
P+T + AP +P A P TPK P + + K+
Sbjct: 565 PTTP-----EEPAPTTPKAA-APNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKG 618
Query: 672 NLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSK 731
P A A LA K DK KG T K +
Sbjct: 619 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP-APTTPKGTAPTTPKEPAPTTP 677
Query: 732 LKSARPIAPA---------PAPTPPQLIA----IPTATFTTTTTGTIPGLPSLTTTVVQA 778
K P P PAPT P+ A PT T T+T + P+
Sbjct: 678 -KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPT 736
Query: 779 TPKSP-PLKPIQPKPTIMGEP 798
TPK P P P +P PT P
Sbjct: 737 TPKEPAPTTPKKPAPTTPETP 757
Score = 33.1 bits (74), Expect = 2.1
Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 4/63 (6%)
Query: 742 PAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQPKPTIMGEPIT 800
P+PT P+ A PT T + TT P TT TPK P P +P PT EP
Sbjct: 421 PSPTTPKEPA-PTTTKSAPTTTKEPA--PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 477
Query: 801 VNP 803
P
Sbjct: 478 TTP 480
Score = 33.1 bits (74), Expect = 2.1
Identities = 37/158 (23%), Positives = 53/158 (33%), Gaps = 24/158 (15%)
Query: 714 KEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTT 773
K+ K T K + S +P P T P P T T P P TT
Sbjct: 702 KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTT 761
Query: 774 TVV-----------------QATPK---SPPLKPIQPKPTIMGEPITVNPAL----VSLK 809
+ V ++TP+ P K ++ P G P T PA ++
Sbjct: 762 SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTT 821
Query: 810 DKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASK 847
K K +R L+ T +PKM + + SK
Sbjct: 822 AKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESK 859
Score = 32.0 bits (71), Expect = 4.7
Identities = 32/98 (32%), Positives = 38/98 (38%), Gaps = 8/98 (8%)
Query: 742 PAPTPPQLIA----IPTATFTTTTTGTIPGLPSLTTTVVQATPKSP-PLKPIQPKPTIM- 795
PAPT P+ A PT T T+T P+ TPK P P P +P PT
Sbjct: 627 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 686
Query: 796 -GEPITV-NPALVSLKDKKKKEKRKLKDKEGKETGSPK 831
P T+ PA + K KE K T S K
Sbjct: 687 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 724
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 47.8 bits (112), Expect = 8e-05
Identities = 97/517 (18%), Positives = 164/517 (31%), Gaps = 70/517 (13%)
Query: 46 QKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSK 105
+K + ST +SSS S+D AT L G++ V T+ +
Sbjct: 985 RKARASESTARSSSSESED-----EDVIPATQCLTPGIRTNVVTMP---------TAHPR 1030
Query: 106 VKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNP 165
+ + A+ S S+ + S GK+QE G AT ++SA+G P
Sbjct: 1031 IAPKASMAGASSSKESSRI-------SDGKKQE-----GPATQVDSAVGTL--------P 1070
Query: 166 NSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGS 225
++ STS A G +K KP + + K + + S ++G
Sbjct: 1071 ATSPQSTSVQAK-------GTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGE 1123
Query: 226 GSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKE 285
G Q H G +P + A + E AP L+ M
Sbjct: 1124 GPQGAKSAHTL---------GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLT 1174
Query: 286 EEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSLTPQILPSYFSPSS--SNIAAPVEQL 343
++ + KL + P PQ SP + A+
Sbjct: 1175 PANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQ 1234
Query: 344 LVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVG 403
R G + + + C G L + VL + K V
Sbjct: 1235 KSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD 1294
Query: 404 TLLDCTKHDWAPPR--------FCESPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESR 455
T + ++ W + +P S + + G G G A+ +P ++ ++ +
Sbjct: 1295 TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG---GEASVSPEKTSTTSKGK 1351
Query: 456 GLQNKNRGGANGKGRRGSLNASGRRTPPN-------CAAEDIKASPSSTNKRKNKPPMEL 508
++K G K +GSL + G + P E S + K K K
Sbjct: 1352 AKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRK 1411
Query: 509 DLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQ 545
E K K+ T +P+ + K + +Q
Sbjct: 1412 KDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1448
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 47.4 bits (111), Expect = 1e-04
Identities = 141/683 (20%), Positives = 229/683 (33%), Gaps = 133/683 (19%)
Query: 696 EMPKLEAEGLIDK---KNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAI 752
E+P E E +I + + G KE G T N ++ S P P P PP + A
Sbjct: 163 ELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQA-STPPQTQTPQPNPPPVQAT 221
Query: 753 PTATFTTTTTGTIPGLPSLTTTVVQATPKSPPLKPI-QPKPTIMGEPITVNPALVSLKDK 811
P F T I P +T Q PP+ P QP P +P+ +P +++ +
Sbjct: 222 PHP-FPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQ 280
Query: 812 KKKEKRKLKDKEGKETGS--------------PKMDAKLGKLEDS----KGASKDLP--- 850
K K+ +K K T + PK KLG+ +S K KD+P
Sbjct: 281 PVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPK-TTKLGQRRESSRPVKPPKKDVPDSQ 339
Query: 851 -------GHFLKDHLNKNEGLANGLSESQESRMA-----SIKAEADKVYTFTDNAPSPSI 898
+ + L G+ + + + A + EA ++ + D P
Sbjct: 340 QHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMD 399
Query: 899 GSA--SRLECSTLVNGQAPMAPLHVLTQN------------------------------- 925
S S+LE + Q A + ++ N
Sbjct: 400 MSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPD 459
Query: 926 GAESSAAKTSSPAYSDISD-AADDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTA 984
E SSPA + A SDS S+ S SD SS D + + A
Sbjct: 460 EPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSD-------SSSDSDSSTDDSEEERAQRLA 512
Query: 985 Q-SSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAE--KK 1041
+ QLK H P Q P + K K + +E+ E KK
Sbjct: 513 ELQEQLKAVHEQLAALSQP----------QQNKPKKKEKDKKEKKKEKHKRKEEVEENKK 562
Query: 1042 DKAEQLDSKKVDHNSASLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMATSPAY 1101
KA++ KK N++S S ++++ PA +S P Y
Sbjct: 563 SKAKEPPPKKTKKNNSS-----NSNVSKKEPAPMKS------------------KPPPTY 599
Query: 1102 RQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGK-EETKQKNMPSATISKAPSTP 1160
+ E + E++ ++LP ++LG+ Q PS K +
Sbjct: 600 ESEEEDKCKPMSYEEKRQLSLD------INKLPGEKLGRVVHIIQSREPSL---KNSNPD 650
Query: 1161 EPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQ-----ADSFKAKQMENHQLIKEAVEM 1215
E + L PS + E S L + Q + A S K K + + + + E
Sbjct: 651 EIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSE-SESSSES 709
Query: 1216 KSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDREKKLKEDSPRKTP 1275
S +T + P S+ K P H+ + + + Q + + + P P
Sbjct: 710 SSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPP 769
Query: 1276 NKESGVPSLPVSLTSIKEEPKEA 1298
++ P P S+ ++ A
Sbjct: 770 PQQQQQPPPPPPPPSMPQQAAPA 792
>gi|71274144 AT hook, DNA binding motif, containing 1 [Homo sapiens]
Length = 1603
Score = 47.4 bits (111), Expect = 1e-04
Identities = 54/265 (20%), Positives = 101/265 (38%), Gaps = 33/265 (12%)
Query: 20 YDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAGATAAL 79
Y+ D + N+I+D+ + ++ + T + SSS+S P G
Sbjct: 1128 YNPSFDCHVSEPNVILDISNYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGG------- 1180
Query: 80 ADGLKFASVQASAPQGNSHKET-SKSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQE 138
G + A+ +AS+ +G S + K + ++ S + + L+ G+R++
Sbjct: 1181 --GFRRANSEASSSEGQSSLSSLEKLMMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKK 1238
Query: 139 VQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSS 198
V G + S S+ SG P+ ST G G+C +K+E+ G + +
Sbjct: 1239 VDLFEASHLGFPT----SASAAASGYPSKRSTGPRQPRGGRGGGAC-SAKKERGGAAAKA 1293
Query: 199 RGAKRDKDAGKSRKDKHDLLQGHQNGSGSQA--PSGGHLYGFGAK--------------- 241
+ + + +D DL + +G S + PS +G G +
Sbjct: 1294 KFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQSRAFGVGERDPCDFIGPYSMNPST 1353
Query: 242 -SNGGGASPFHCGGTGSGSVAAAGE 265
S+G FHC G+ G+
Sbjct: 1354 PSDGTFGQGFHCDSPSLGAPELDGK 1378
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 47.0 bits (110), Expect = 1e-04
Identities = 97/517 (18%), Positives = 164/517 (31%), Gaps = 69/517 (13%)
Query: 46 QKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSK 105
+K + ST +SSS S+D AT L G++ V T+ +
Sbjct: 985 RKARASESTARSSSSESED-----EDVIPATQCLTPGIRTNVVTMP---------TAHPR 1030
Query: 106 VKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNP 165
+ + A+ S S+ + S GK+QE G AT ++SA+G P
Sbjct: 1031 IAPKASMAGASSSKESSRI-------SDGKKQE-----GPATQVDSAVGTL--------P 1070
Query: 166 NSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGS 225
++ STS A G +K KP + + K + + S ++G
Sbjct: 1071 ATSPQSTSVQAK-------GTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGE 1123
Query: 226 GSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKE 285
G Q H G +P + A + E AP L+ M
Sbjct: 1124 GPQGAKSAHTL--------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLT 1175
Query: 286 EEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSLTPQILPSYFSPSS--SNIAAPVEQL 343
++ + KL + P PQ SP + A+
Sbjct: 1176 PANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQ 1235
Query: 344 LVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVG 403
R G + + + C G L + VL + K V
Sbjct: 1236 KSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD 1295
Query: 404 TLLDCTKHDWAPPR--------FCESPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESR 455
T + ++ W + +P S + + G G G A+ +P ++ ++ +
Sbjct: 1296 TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG---GEASVSPEKTSTTSKGK 1352
Query: 456 GLQNKNRGGANGKGRRGSLNASGRRTPPN-------CAAEDIKASPSSTNKRKNKPPMEL 508
++K G K +GSL + G + P E S + K K K
Sbjct: 1353 AKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRK 1412
Query: 509 DLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQ 545
E K K+ T +P+ + K + +Q
Sbjct: 1413 KDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1449
>gi|150456424 RW1 protein [Homo sapiens]
Length = 1883
Score = 46.2 bits (108), Expect = 2e-04
Identities = 94/422 (22%), Positives = 153/422 (36%), Gaps = 56/422 (13%)
Query: 677 SNMTAALDSCSAADGSLAAEMPKL--EAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKS 734
S+ T++ S AA A + L ++ + G K KG K + + +
Sbjct: 1240 SSSTSSRTSAQAASSQSANKTSPLVLDSNTVTQGHTAGRKSKGAKQSQHGSQHHAHSPLE 1299
Query: 735 ARPIAPAPAPTP-----------PQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPK-- 781
P P P P P P +A P+ ++ S T++++A K
Sbjct: 1300 QHPQPPLPPPVPQPQEPQPERLSPAPLAHPSHP-ERASSARHSSEDSDITSLIEAMDKDF 1358
Query: 782 ----SPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLG 837
SP L+ +P P+ + +K K +K ++KE K G P+ D
Sbjct: 1359 DHHDSPALEVFTEQPP---SPLPKSKGKGKPLQRKVKPPKKQEEKEKKGKGKPQEDELKD 1415
Query: 838 KLEDSKGASKDLPGH------FLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTD 891
L D +S LK+ K +G + E ES M+ +K ++ K+
Sbjct: 1416 SLADDDSSSTTTETSNPDTEPLLKEDTEKQKG-KQAMPEKHESEMSQVKQKSKKLLNIKK 1474
Query: 892 NAPSPSIGSASRLECSTLVNGQ-----APMAPLHVLTQNGAES-SAAKTSS--------- 936
P+ S+ L + + + PL +G++S +A KT
Sbjct: 1475 EIPTDVKPSSLELPYTPPLESKQRRNLPSKIPLPTAMTSGSKSRNAQKTKGTSKLVDNRP 1534
Query: 937 PAYSDISDAADDGGSDSRSEGMRSKASSPSDII------SSKDSVVKGHSSTTAQSSQLK 990
PA + + + G+ S SEG + D + SS DS+ K T LK
Sbjct: 1535 PALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLK 1594
Query: 991 ESH-SPYYHSYDPYYSP-SYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLD 1048
+ SP S P +P ++ G + NS S+ KI K+ K KA L
Sbjct: 1595 QRQTSPTPASPSPPAAPCPFVARGSYSSIV--NSSSSSDPKI-KQPNGSKHKLTKAASLP 1651
Query: 1049 SK 1050
K
Sbjct: 1652 GK 1653
>gi|7657218 bromodomain-containing protein 4 isoform short [Homo
sapiens]
Length = 722
Score = 45.8 bits (107), Expect = 3e-04
Identities = 38/136 (27%), Positives = 56/136 (41%), Gaps = 6/136 (4%)
Query: 696 EMPKLEAEGLIDK---KNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAI 752
E+P E E +I + + G KE G T N ++ S P P P PP + A
Sbjct: 163 ELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQA-STPPQTQTPQPNPPPVQAT 221
Query: 753 PTATFTTTTTGTIPGLPSLTTTVVQATPKSPPLKPI-QPKPTIMGEPITVNPALVSLKDK 811
P F T I P +T Q PP+ P QP P +P+ +P +++ +
Sbjct: 222 PHP-FPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQ 280
Query: 812 KKKEKRKLKDKEGKET 827
K K+ +K K T
Sbjct: 281 PVKTKKGVKRKADTTT 296
Score = 31.6 bits (70), Expect = 6.1
Identities = 43/193 (22%), Positives = 78/193 (40%), Gaps = 42/193 (21%)
Query: 1005 SPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQ 1064
SP+ P +V AP + + S+ S +D+E+ ++A++L A LQ Q +
Sbjct: 470 SPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEE-ERAQRL---------AELQEQLK 519
Query: 1065 SVITQRHPALAQSLYYGQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGR 1124
+V Q AL+Q +Q K E + ++K +
Sbjct: 520 AVHEQL-AALSQP------------------------QQNKPKKKEKDKKEKKKEKHKRK 554
Query: 1125 GDCERKSELPLKELGKEETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQ 1184
+ E + KE ++TK+ N ++ +SK P +K P ++EE K +
Sbjct: 555 EEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSK------PPPTYESEEEDKCK 608
Query: 1185 LLS-NHQQQLQAD 1196
+S ++QL D
Sbjct: 609 PMSYEEKRQLSLD 621
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 45.8 bits (107), Expect = 3e-04
Identities = 90/438 (20%), Positives = 169/438 (38%), Gaps = 48/438 (10%)
Query: 1018 AAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSVITQRHPALAQS 1077
A N+ T + + +ED K ++ K +D +Q + +++ +
Sbjct: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
Query: 1078 LYYGQYAYGLYMDQKSLMATSPA----YRQQYEKYYEDQRLAEQ-KMAQTGRGDCERKSE 1132
Y + L Q +M TS +++Q+ E Q L E A+T E + E
Sbjct: 1443 TQYEE----LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVE 1498
Query: 1133 LPLKELGKEETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKT-EETGKSQLLSNHQQ 1191
K L ++ET+ +N+ T+ + S+L + ++T +E Q ++ ++
Sbjct: 1499 NLQKTLSEKETEARNLQEQTV-------QLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
Query: 1192 QLQADSFKAKQMENH------QLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTW--- 1242
+ + AK H QL KE E+K ++ Q K + D R
Sbjct: 1552 KTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQ--------KDELDVRITALK 1603
Query: 1243 HHYVYQPKYLDQQKSEELDREKKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPD 1302
Y + L+++ E +R + + D P++ NK VP +T +K P +
Sbjct: 1604 SQYEGRISRLERELREHQERHLE-QRDEPQEPSNK---VPEQQRQIT-LKTTPASGERGI 1658
Query: 1303 SQSMEESKLKNDDRKTPVNWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAY 1362
+ + + + + TPV S+ T A++ S ++ I+ + + +P+
Sbjct: 1659 ASTSDPPTA--NIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPM--VTPATVTNPTTTPT 1714
Query: 1363 RAVSPVLMHSYPGAYLSPG--FHYPVYGKMSGREETEKVNTSPSVNTKTTT---ESKALD 1417
V P A S G H PV+G SG + N PS++ T +++A
Sbjct: 1715 ATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATA 1774
Query: 1418 LLQQHANQYRSKSPAPVE 1435
+Q + PA E
Sbjct: 1775 FVQPTQQSHPQIEPANQE 1792
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 45.4 bits (106), Expect = 4e-04
Identities = 55/252 (21%), Positives = 96/252 (38%), Gaps = 25/252 (9%)
Query: 45 RQKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKS 104
+ + +S ++ S S S+ G S + + + S + S + +
Sbjct: 203 KSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSA 262
Query: 105 KVKRSKTSKDANKSLPSAALYGIPEISSTGK---RQEVQGRPGEATGMNSALGQSVSSGG 161
RSK+ A + + + G P+ S + + + + R E G SVS G
Sbjct: 263 GKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRG-SVSRGR 321
Query: 162 SGNPN---SNSTSTSTSAATAGAGSCGKSKEEKPGKSQS------------------SRG 200
S + S S S S + + + S KSK+++ G+ +S RG
Sbjct: 322 SQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRG 381
Query: 201 AKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSV 260
+KRD AG S+K K + Q+ S S++ S + S G GT +
Sbjct: 382 SKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETR 441
Query: 261 AAAGEVSKSAPD 272
+ + SKS P+
Sbjct: 442 SRSRSNSKSKPN 453
Score = 39.7 bits (91), Expect = 0.022
Identities = 23/114 (20%), Positives = 56/114 (49%), Gaps = 4/114 (3%)
Query: 421 SPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRR 480
S + + R GR R + + + S++ + RG + ++ G++ K ++ + S R
Sbjct: 346 SRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSR 405
Query: 481 TPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTP 534
+P +++ + + S +++R+ + E ++ + + R R+NS+S P P
Sbjct: 406 SPSRSVSKEREHAKSESSQREGRGESE----NAGTNQETRSRSRSNSKSKPNLP 455
Score = 32.7 bits (73), Expect = 2.7
Identities = 36/177 (20%), Positives = 65/177 (36%), Gaps = 14/177 (7%)
Query: 38 DADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNS 97
+ L + R + + + S S SK + + + + S +G+
Sbjct: 324 EKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSK 383
Query: 98 HKETSKSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSV 157
+ S K+ K D ++S P S + +R+ + + G G+S
Sbjct: 384 RDSKAGSSKKKKKEDTDRSQSRS-------PSRSVSKEREHAKSESSQREGR----GESE 432
Query: 158 SSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQS---SRGAKRDKDAGKSR 211
++G + S S S S S + S +SK +S+S SR A R +SR
Sbjct: 433 NAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSR 489
Score = 32.3 bits (72), Expect = 3.6
Identities = 27/110 (24%), Positives = 45/110 (40%), Gaps = 4/110 (3%)
Query: 421 SPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRR 480
S +S + R G R+RS + + S + SR + K+R + K R S +A R
Sbjct: 211 SKSSHSKSRSRSRSGSRSRSKSRS----RSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSR 266
Query: 481 TPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRST 530
+ AE+ + + K K++ P S S +RV R +
Sbjct: 267 SKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGS 316
Score = 32.0 bits (71), Expect = 4.7
Identities = 62/336 (18%), Positives = 115/336 (34%), Gaps = 30/336 (8%)
Query: 947 DDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSP 1006
D GS R RS++ S S S + S ++ S S S S S
Sbjct: 175 DKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRS---RSGSRSRSK 231
Query: 1007 SYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSV 1066
S S S K + S + + K++ +K+ +N +P+ +S
Sbjct: 232 SRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRS- 290
Query: 1067 ITQRHPALAQSLYYGQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGD 1126
RH + ++S Q ++++ + S R Q + + + + K R
Sbjct: 291 -PSRHKSKSKSRSRSQERR---VEEEKRGSVSRG-RSQEKSLRQSRSRSRSKGGSRSRSR 345
Query: 1127 CERKSELPLKELGKEETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLL 1186
KS+ K + + ++ + S +K SK G S K E+T +SQ
Sbjct: 346 SRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQ-- 403
Query: 1187 SNHQQQLQADSFKAKQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYV 1246
+ + + KE KS + G + Q+ SR+ +
Sbjct: 404 --------------SRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSK 449
Query: 1247 YQPKYLDQQKSEELDREK-----KLKEDSPRKTPNK 1277
+P + +S K K + S ++P++
Sbjct: 450 SKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSR 485
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 45.1 bits (105), Expect = 5e-04
Identities = 59/236 (25%), Positives = 99/236 (41%), Gaps = 32/236 (13%)
Query: 1125 GDCER--KSELPLKELGKEETKQKNMPSATISKAPS--TPEPNKNHSKLGP----SVPNK 1176
G+ ER +SE P+K+ +E K N S++ S+ T P K HSK + P K
Sbjct: 1013 GERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVK 1072
Query: 1177 TEETGK-------SQLLSNHQQQLQADSFKAKQMENH-QLIKEAVEMKSV-----MDSMK 1223
E+ K S+ L+ +++ + + K K ++N + K E K V SMK
Sbjct: 1073 EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMK 1132
Query: 1224 QTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDREKKLKEDSPRKTP--NKESGV 1281
+ ++ T K P + +P D +K + + K+ +P K N+E+G
Sbjct: 1133 ISKLEVTEIVKPSPKRKM------EP---DTEKMDRTPEKDKISLSAPAKKIKLNRETGK 1183
Query: 1282 PSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPVNWKDSRGTRVAVSSPMS 1337
S +EP E S +++ K+K R+ + S T V +S S
Sbjct: 1184 KIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSS 1239
Score = 34.3 bits (77), Expect = 0.94
Identities = 100/529 (18%), Positives = 190/529 (35%), Gaps = 91/529 (17%)
Query: 821 DKEGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIK 880
+K G + D K ++S+ A D G+ K H + +G + + E S K
Sbjct: 866 EKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK 925
Query: 881 AEADKVYTFTDNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSP-AY 939
+ T + + S+ + +T V + PM + ++ +E + P A
Sbjct: 926 SREP---TGVEENKTDSLFVLPSRDDATPVRDE-PMDAESITFKSVSEKDKRERDKPKAK 981
Query: 940 SDISDAADDGGSDSRSEGMRSKASSPSDIISSK-------DSVVKGHSSTTAQSSQLKES 992
D + +DG + S+ E + A P + + + + +K T ++ K S
Sbjct: 982 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSS 1041
Query: 993 HSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKV 1052
S S G P +S S + + K +E+ KKD ++ + S+K+
Sbjct: 1042 SS------------SQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKL 1089
Query: 1053 DHNSASLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQ 1112
+ ++ + P +D K + +K +E
Sbjct: 1090 TTKEEKAKKPNE----KNKP----------------LDNKGEKRKRKTEEKGVDKDFESS 1129
Query: 1113 RLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNMPSATISKAPSTPEPNKNHSKLGPS 1172
+ + S+L + E+ K K+K P K TPE +K
Sbjct: 1130 SM--------------KISKLEVTEIVKPSPKRKMEPDT--EKMDRTPEKDKISLSAPAK 1173
Query: 1173 VPNKTEETGK----SQLLSNHQ---QQLQADSFKAKQMENHQLIKEAV-----EMKSVMD 1220
ETGK ++ +SN + ++L++ S K KQ + ++ V +++D
Sbjct: 1174 KIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVD 1233
Query: 1221 --SMKQTGVDPTSRFKQDPDS-----RTWHHY----------VYQPKYLDQQKSEELDRE 1263
S TG P + ++ D+ +T Y V + Q K ++ D E
Sbjct: 1234 YTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFE 1293
Query: 1264 KKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLK 1312
+ +ED P G P+ + S K K+P+ +S K++
Sbjct: 1294 SE-EEDVKSTQPISSVGKPASVIKNVSTKPS-NIVKYPEKESEPSEKIQ 1340
Score = 32.7 bits (73), Expect = 2.7
Identities = 40/214 (18%), Positives = 78/214 (36%), Gaps = 23/214 (10%)
Query: 1101 YRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNMPSATISKAPSTP 1160
YR+ YEKYY+ Q R + + LPL +N P +
Sbjct: 800 YREWYEKYYKGYAAGAQPRPSANRENFSPERFLPL--------NIRNSPFTRGRREDYVG 851
Query: 1161 EPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKAKQMENHQLIKEAVEMKSVMD 1220
+ +G + P K LS Q D+ K+K+ E+ + K
Sbjct: 852 GQSHRSRNIGSNYPEK---------LSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKH 902
Query: 1221 SMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDREKKLKEDSPRKTPNKESG 1280
++ G + S +P+ +P +++ K++ L + TP ++
Sbjct: 903 RKRRKGEE--SEGFLNPELLETSRKSREPTGVEENKTDSL----FVLPSRDDATPVRDEP 956
Query: 1281 VPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKND 1314
+ + ++ S+ E+ K + +++K KND
Sbjct: 957 MDAESITFKSVSEKDKRERDKPKAKGDKTKRKND 990
Score = 32.7 bits (73), Expect = 2.7
Identities = 34/152 (22%), Positives = 59/152 (38%), Gaps = 20/152 (13%)
Query: 95 GNSHKETSKSKVKRSKTSK---DANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNS 151
G K T K K + S +S+ D + AA P+ + + V + E++G S
Sbjct: 1571 GQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE--PDYNESDSESNVSVKEEESSGNIS 1628
Query: 152 A---------------LGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQ 196
V G S N + +S S S S + + +GS +S ++
Sbjct: 1629 KDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAE 1688
Query: 197 SSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQ 228
S K+ K K + KH + H+ +G++
Sbjct: 1689 SQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTE 1720
Score = 31.2 bits (69), Expect = 7.9
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 39/271 (14%)
Query: 810 DKKKKEKRKLKDK---EGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLAN 866
D KK +D+ + K T K + K D K KD H L+ NK E N
Sbjct: 1494 DSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVD-KNPCKDREKHVLEARNNK-ESSGN 1551
Query: 867 GL------SESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLECS-TLVNGQAPMAPL 919
L E+Q + I + DK + P P + +SRL T +A P
Sbjct: 1552 KLLYILNPPETQVEK-EQITGQIDK----STVKPKPQLSHSSRLSSDLTRETDEAAFEPD 1606
Query: 920 HVLTQNGAESSAA----KTSSPAYSDISDAADDGGSDS------------RSEGMRSKAS 963
+ ++ +ES+ + ++S D+ D + +S R++ S +
Sbjct: 1607 Y--NESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSV 1664
Query: 964 SPSDIISSKDSVVKGHSS--TTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGN 1021
SPS S S + HSS ++A+S K+ + H G
Sbjct: 1665 SPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEV--E 1722
Query: 1022 SGSTQGMKIKKESEEDAEKKDKAEQLDSKKV 1052
+Q K KK+ + + K+K ++ D +KV
Sbjct: 1723 LEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1753
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 45.1 bits (105), Expect = 5e-04
Identities = 59/236 (25%), Positives = 99/236 (41%), Gaps = 32/236 (13%)
Query: 1125 GDCER--KSELPLKELGKEETKQKNMPSATISKAPS--TPEPNKNHSKLGP----SVPNK 1176
G+ ER +SE P+K+ +E K N S++ S+ T P K HSK + P K
Sbjct: 1047 GERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVK 1106
Query: 1177 TEETGK-------SQLLSNHQQQLQADSFKAKQMENH-QLIKEAVEMKSV-----MDSMK 1223
E+ K S+ L+ +++ + + K K ++N + K E K V SMK
Sbjct: 1107 EEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMK 1166
Query: 1224 QTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDREKKLKEDSPRKTP--NKESGV 1281
+ ++ T K P + +P D +K + + K+ +P K N+E+G
Sbjct: 1167 ISKLEVTEIVKPSPKRKM------EP---DTEKMDRTPEKDKISLSAPAKKIKLNRETGK 1217
Query: 1282 PSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPVNWKDSRGTRVAVSSPMS 1337
S +EP E S +++ K+K R+ + S T V +S S
Sbjct: 1218 KIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSS 1273
Score = 34.3 bits (77), Expect = 0.94
Identities = 100/529 (18%), Positives = 190/529 (35%), Gaps = 91/529 (17%)
Query: 821 DKEGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIK 880
+K G + D K ++S+ A D G+ K H + +G + + E S K
Sbjct: 900 EKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK 959
Query: 881 AEADKVYTFTDNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSP-AY 939
+ T + + S+ + +T V + PM + ++ +E + P A
Sbjct: 960 SREP---TGVEENKTDSLFVLPSRDDATPVRDE-PMDAESITFKSVSEKDKRERDKPKAK 1015
Query: 940 SDISDAADDGGSDSRSEGMRSKASSPSDIISSK-------DSVVKGHSSTTAQSSQLKES 992
D + +DG + S+ E + A P + + + + +K T ++ K S
Sbjct: 1016 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSS 1075
Query: 993 HSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKV 1052
S S G P +S S + + K +E+ KKD ++ + S+K+
Sbjct: 1076 SS------------SQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKL 1123
Query: 1053 DHNSASLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQ 1112
+ ++ + P +D K + +K +E
Sbjct: 1124 TTKEEKAKKPNE----KNKP----------------LDNKGEKRKRKTEEKGVDKDFESS 1163
Query: 1113 RLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNMPSATISKAPSTPEPNKNHSKLGPS 1172
+ + S+L + E+ K K+K P K TPE +K
Sbjct: 1164 SM--------------KISKLEVTEIVKPSPKRKMEPDT--EKMDRTPEKDKISLSAPAK 1207
Query: 1173 VPNKTEETGK----SQLLSNHQ---QQLQADSFKAKQMENHQLIKEAV-----EMKSVMD 1220
ETGK ++ +SN + ++L++ S K KQ + ++ V +++D
Sbjct: 1208 KIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVD 1267
Query: 1221 --SMKQTGVDPTSRFKQDPDS-----RTWHHY----------VYQPKYLDQQKSEELDRE 1263
S TG P + ++ D+ +T Y V + Q K ++ D E
Sbjct: 1268 YTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFE 1327
Query: 1264 KKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLK 1312
+ +ED P G P+ + S K K+P+ +S K++
Sbjct: 1328 SE-EEDVKSTQPISSVGKPASVIKNVSTKPS-NIVKYPEKESEPSEKIQ 1374
Score = 32.7 bits (73), Expect = 2.7
Identities = 40/214 (18%), Positives = 78/214 (36%), Gaps = 23/214 (10%)
Query: 1101 YRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNMPSATISKAPSTP 1160
YR+ YEKYY+ Q R + + LPL +N P +
Sbjct: 834 YREWYEKYYKGYAAGAQPRPSANRENFSPERFLPL--------NIRNSPFTRGRREDYVG 885
Query: 1161 EPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKAKQMENHQLIKEAVEMKSVMD 1220
+ +G + P K LS Q D+ K+K+ E+ + K
Sbjct: 886 GQSHRSRNIGSNYPEK---------LSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKH 936
Query: 1221 SMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDREKKLKEDSPRKTPNKESG 1280
++ G + S +P+ +P +++ K++ L + TP ++
Sbjct: 937 RKRRKGEE--SEGFLNPELLETSRKSREPTGVEENKTDSL----FVLPSRDDATPVRDEP 990
Query: 1281 VPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKND 1314
+ + ++ S+ E+ K + +++K KND
Sbjct: 991 MDAESITFKSVSEKDKRERDKPKAKGDKTKRKND 1024
Score = 32.7 bits (73), Expect = 2.7
Identities = 34/152 (22%), Positives = 59/152 (38%), Gaps = 20/152 (13%)
Query: 95 GNSHKETSKSKVKRSKTSK---DANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNS 151
G K T K K + S +S+ D + AA P+ + + V + E++G S
Sbjct: 1605 GQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE--PDYNESDSESNVSVKEEESSGNIS 1662
Query: 152 A---------------LGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQ 196
V G S N + +S S S S + + +GS +S ++
Sbjct: 1663 KDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAE 1722
Query: 197 SSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQ 228
S K+ K K + KH + H+ +G++
Sbjct: 1723 SQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTE 1754
Score = 31.2 bits (69), Expect = 7.9
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 39/271 (14%)
Query: 810 DKKKKEKRKLKDK---EGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLAN 866
D KK +D+ + K T K + K D K KD H L+ NK E N
Sbjct: 1528 DSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVD-KNPCKDREKHVLEARNNK-ESSGN 1585
Query: 867 GL------SESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLECS-TLVNGQAPMAPL 919
L E+Q + I + DK + P P + +SRL T +A P
Sbjct: 1586 KLLYILNPPETQVEK-EQITGQIDK----STVKPKPQLSHSSRLSSDLTRETDEAAFEPD 1640
Query: 920 HVLTQNGAESSAA----KTSSPAYSDISDAADDGGSDS------------RSEGMRSKAS 963
+ ++ +ES+ + ++S D+ D + +S R++ S +
Sbjct: 1641 Y--NESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSV 1698
Query: 964 SPSDIISSKDSVVKGHSS--TTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGN 1021
SPS S S + HSS ++A+S K+ + H G
Sbjct: 1699 SPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEV--E 1756
Query: 1022 SGSTQGMKIKKESEEDAEKKDKAEQLDSKKV 1052
+Q K KK+ + + K+K ++ D +KV
Sbjct: 1757 LEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1787
>gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo
sapiens]
Length = 634
Score = 44.7 bits (104), Expect = 7e-04
Identities = 76/372 (20%), Positives = 131/372 (35%), Gaps = 61/372 (16%)
Query: 490 IKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSS 549
+K+ + + + PP+E +ED K + + + P P P
Sbjct: 116 VKSEEGNGSVSEKTPPLE----EQAEDKKENTENHSETPAAPALPPSAPPKPR------- 164
Query: 550 PVLIDCPHPNCNKKYKHINGLRYHQAHA--HLDPENKLEFEPDSEDKISDCEEGLSNVAL 607
P P K G +H + P K P + + + N
Sbjct: 165 ------PKPKPKKSPVPPKGATAGASHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTR 218
Query: 608 ECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLN 667
E + S S KA ASP + PK +E +S+ G++ G GK+K
Sbjct: 219 EAAGSSHSKKTTGS-KASASPSTSSTSSRPKASKETVSSKAGTV-----GTTKGKRK--- 269
Query: 668 NELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDK 727
+ P+ S++++ D+ ++ L E + E ++ + E ++
Sbjct: 270 --TDKQPITSHLSS--DTTTSGTSDLKGEPAETRVESFKLEQTVPGAE----------EQ 315
Query: 728 NLSKLKS---ARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSPP 784
N K KS P+APAP+P P L P T S T V+ + P
Sbjct: 316 NTGKFKSMVPPPPVAPAPSPLAPPL---PLEDQCITA--------SDTPVVLVSVGADLP 364
Query: 785 LKPIQPKPTIMGEPITVNPALVS----LKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLE 840
+ + P + E T L S +++ + K++ GK +G+
Sbjct: 365 VSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESS 424
Query: 841 DSKGASKDLPGH 852
+S AS+D GH
Sbjct: 425 ESFSASED-EGH 435
>gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo
sapiens]
Length = 645
Score = 44.7 bits (104), Expect = 7e-04
Identities = 76/372 (20%), Positives = 131/372 (35%), Gaps = 61/372 (16%)
Query: 490 IKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSS 549
+K+ + + + PP+E +ED K + + + P P P
Sbjct: 127 VKSEEGNGSVSEKTPPLE----EQAEDKKENTENHSETPAAPALPPSAPPKPR------- 175
Query: 550 PVLIDCPHPNCNKKYKHINGLRYHQAHA--HLDPENKLEFEPDSEDKISDCEEGLSNVAL 607
P P K G +H + P K P + + + N
Sbjct: 176 ------PKPKPKKSPVPPKGATAGASHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTR 229
Query: 608 ECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLN 667
E + S S KA ASP + PK +E +S+ G++ G GK+K
Sbjct: 230 EAAGSSHSKKTTGS-KASASPSTSSTSSRPKASKETVSSKAGTV-----GTTKGKRK--- 280
Query: 668 NELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDK 727
+ P+ S++++ D+ ++ L E + E ++ + E ++
Sbjct: 281 --TDKQPITSHLSS--DTTTSGTSDLKGEPAETRVESFKLEQTVPGAE----------EQ 326
Query: 728 NLSKLKS---ARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSPP 784
N K KS P+APAP+P P L P T S T V+ + P
Sbjct: 327 NTGKFKSMVPPPPVAPAPSPLAPPL---PLEDQCITA--------SDTPVVLVSVGADLP 375
Query: 785 LKPIQPKPTIMGEPITVNPALVS----LKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLE 840
+ + P + E T L S +++ + K++ GK +G+
Sbjct: 376 VSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESS 435
Query: 841 DSKGASKDLPGH 852
+S AS+D GH
Sbjct: 436 ESFSASED-EGH 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,693,861
Number of Sequences: 37866
Number of extensions: 3635952
Number of successful extensions: 22847
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 662
Number of HSP's that attempted gapping in prelim test: 17457
Number of HSP's gapped (non-prelim): 5294
length of query: 1512
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1397
effective length of database: 13,892,928
effective search space: 19408420416
effective search space used: 19408420416
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.