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Search of human proteins with 153252026
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153252026 chloride channel 4 [Homo sapiens]
(760 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153252026 chloride channel 4 [Homo sapiens] 1542 0.0
gi|55770838 chloride channel 3 isoform b [Homo sapiens] 1268 0.0
gi|55770840 chloride channel 3 isoform e [Homo sapiens] 1238 0.0
gi|189217923 chloride channel 5 isoform a [Homo sapiens] 1235 0.0
gi|189217921 chloride channel 5 isoform a [Homo sapiens] 1235 0.0
gi|4557473 chloride channel 5 isoform b [Homo sapiens] 1228 0.0
gi|167466160 chloride channel 7 isoform b [Homo sapiens] 253 4e-67
gi|14149607 chloride channel 7 isoform a [Homo sapiens] 253 4e-67
gi|156104869 chloride channel 2 [Homo sapiens] 220 3e-57
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] 217 3e-56
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] 201 2e-51
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] 194 2e-49
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] 193 4e-49
gi|155969705 chloride channel Kb [Homo sapiens] 186 9e-47
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] 114 3e-25
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] 66 1e-10
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] 66 1e-10
gi|117606362 anterior pharynx defective 1 homolog A isoform 1 [H... 32 2.2
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens] 32 2.9
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens] 32 2.9
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H... 32 2.9
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 31 4.9
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 31 4.9
>gi|153252026 chloride channel 4 [Homo sapiens]
Length = 760
Score = 1542 bits (3992), Expect = 0.0
Identities = 760/760 (100%), Positives = 760/760 (100%)
Query: 1 MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF 60
MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF
Sbjct: 1 MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF 60
Query: 61 IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE 120
IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE
Sbjct: 61 IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE 120
Query: 121 TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG 180
TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG
Sbjct: 121 TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG 180
Query: 181 SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS 240
SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS
Sbjct: 181 SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS 240
Query: 241 LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300
LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV
Sbjct: 241 LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300
Query: 301 AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR 360
AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR
Sbjct: 301 AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR 360
Query: 361 KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP 420
KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP
Sbjct: 361 KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP 420
Query: 421 NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG 480
NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG
Sbjct: 421 NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG 480
Query: 481 RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF 540
RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF
Sbjct: 481 RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF 540
Query: 541 ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM 600
ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM
Sbjct: 541 ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM 600
Query: 601 RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN 660
RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN
Sbjct: 601 RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN 660
Query: 661 ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL 720
ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL
Sbjct: 661 ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL 720
Query: 721 GLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760
GLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN
Sbjct: 721 GLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760
>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
Length = 818
Score = 1268 bits (3281), Expect = 0.0
Identities = 594/760 (78%), Positives = 677/760 (89%)
Query: 1 MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF 60
M N G+++ S +L+D LDEP P VGTY+DFHTIDW+REK +D +RHR+I SK KES WE
Sbjct: 59 MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEM 118
Query: 61 IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE 120
KSL DAWSGW+V+ L GL +G LAG+ID+A DWMTDLKEG+CLSA WY+HEQCCW SNE
Sbjct: 119 TKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNE 178
Query: 121 TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG 180
TTFE+RDKCP W+ W+EL++ Q+EG +YI+NY+MYI WAL FAFLAVSLV+VFAPYACG
Sbjct: 179 TTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACG 238
Query: 181 SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS 240
SGIPEIKTILSGFIIRGYLGKWTL+IKT+TLVL V+SGLSLGKEGPLVHVACCCGN FS
Sbjct: 239 SGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSY 298
Query: 241 LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300
LF KYS NE K+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV
Sbjct: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
Query: 301 AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR 360
AAF LRSINPFGNSRLVLFYVEYHTPWY+ ELFPFILLGVFGGLWG FIR NIAWCRRR
Sbjct: 359 AAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRR 418
Query: 361 KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP 420
K+T+ GKYPVLEVI+V AITA+IA+PNPYTR +TSELI ELF DCG LESS LCDY ND
Sbjct: 419 KSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDM 478
Query: 421 NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG 480
N ++ VDDIPDRPAG+GVY+A+WQL LALIFKI++T+FTFG+K+PSGLFIPSMA+GAIAG
Sbjct: 479 NASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAG 538
Query: 481 RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF 540
R+VGI VEQLAY+HHDW IF+ WC GADC+TPGLYAMVGAAACLGGVTRMTVSLVVI+F
Sbjct: 539 RIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVF 598
Query: 541 ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM 600
ELTGGLEYIVPLMAA +TSKWV DAFG+EGIYEAHI LNGYPFLD K+EFTH TLA DVM
Sbjct: 599 ELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVM 658
Query: 601 RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN 660
RPRR +PPL+VLTQD+MTV+D+E +I ET YNGFPV++S++S+RL+GFA RR+L +AI++
Sbjct: 659 RPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIES 718
Query: 661 ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL 720
AR++QEGIV +S + F + P LPA SP PLKLR IL++SPFTVTDHTPME VVDIFRKL
Sbjct: 719 ARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKL 778
Query: 721 GLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760
GLRQCLVT +GRLLGIITKKD+LRHMAQ ANQDP SIMFN
Sbjct: 779 GLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN 818
>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
Length = 866
Score = 1238 bits (3203), Expect = 0.0
Identities = 578/749 (77%), Positives = 665/749 (88%)
Query: 1 MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF 60
M N G+++ S +L+D LDEP P VGTY+DFHTIDW+REK +D +RHR+I SK KES WE
Sbjct: 59 MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEM 118
Query: 61 IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE 120
KSL DAWSGW+V+ L GL +G LAG+ID+A DWMTDLKEG+CLSA WY+HEQCCW SNE
Sbjct: 119 TKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNE 178
Query: 121 TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG 180
TTFE+RDKCP W+ W+EL++ Q+EG +YI+NY+MYI WAL FAFLAVSLV+VFAPYACG
Sbjct: 179 TTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACG 238
Query: 181 SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS 240
SGIPEIKTILSGFIIRGYLGKWTL+IKT+TLVL V+SGLSLGKEGPLVHVACCCGN FS
Sbjct: 239 SGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSY 298
Query: 241 LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300
LF KYS NE K+REVLSAA+AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV
Sbjct: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
Query: 301 AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR 360
AAF LRSINPFGNSRLVLFYVEYHTPWY+ ELFPFILLGVFGGLWG FIR NIAWCRRR
Sbjct: 359 AAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRR 418
Query: 361 KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP 420
K+T+ GKYPVLEVI+V AITA+IA+PNPYTR +TSELI ELF DCG LESS LCDY ND
Sbjct: 419 KSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDM 478
Query: 421 NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG 480
N ++ VDDIPDRPAG+GVY+A+WQL LALIFKI++T+FTFG+K+PSGLFIPSMA+GAIAG
Sbjct: 479 NASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAG 538
Query: 481 RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF 540
R+VGI VEQLAY+HHDW IF+ WC GADC+TPGLYAMVGAAACLGGVTRMTVSLVVI+F
Sbjct: 539 RIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVF 598
Query: 541 ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM 600
ELTGGLEYIVPLMAA +TSKWV DAFG+EGIYEAHI LNGYPFLD K+EFTH TLA DVM
Sbjct: 599 ELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVM 658
Query: 601 RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN 660
RPRR +PPL+VLTQD+MTV+D+E +I ET YNGFPV++S++S+RL+GFA RR+L +AI++
Sbjct: 659 RPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIES 718
Query: 661 ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL 720
AR++QEGIV +S + F + P LPA SP PLKLR IL++SPFTVTDHTPME VVDIFRKL
Sbjct: 719 ARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKL 778
Query: 721 GLRQCLVTRSGRLLGIITKKDVLRHMAQM 749
GLRQCLVT +G +LGIITKK++L H+ Q+
Sbjct: 779 GLRQCLVTHNGIVLGIITKKNILEHLEQL 807
>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 1235 bits (3195), Expect = 0.0
Identities = 588/758 (77%), Positives = 674/758 (88%), Gaps = 1/758 (0%)
Query: 3 NAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIK 62
N G + S +MDFL+EP P VGTY+DF+TIDW+REKSRD DRHR+IT+KSKES W I
Sbjct: 60 NGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIH 119
Query: 63 SLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETT 122
S+ DA+SGW++MLLIGLL+G+LAG+ID++ WMTDLKEG+C FW++HE CCW S T
Sbjct: 120 SVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVT 179
Query: 123 FEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSG 182
FE+RDKCP W WS+L+++ EGA AYI+NY MY+LWALLFAFLAVSLV+VFAPYACGSG
Sbjct: 180 FEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSG 239
Query: 183 IPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLF 242
IPEIKTILSGFIIRGYLGKWTL+IKT+TLVL VSSGLSLGKEGPLVHVACCCGN F
Sbjct: 240 IPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCF 299
Query: 243 SKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 302
+KY KNE KRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
Sbjct: 300 NKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 359
Query: 303 FTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKT 362
FTLRSINPFGNSRLVLFYVE+HTPW++ EL PFILLG+FGGLWG LFIR NIAWCR+RKT
Sbjct: 360 FTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKT 419
Query: 363 TRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNM 422
T+LGKYPV+EV+VVTAITAI+A+PN YTR STSELISELFNDCG L+SS+LCDY N N
Sbjct: 420 TQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFN- 478
Query: 423 TRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRM 482
T ++PDRPAGVGVY+AMWQLAL LI KIV+TIFTFGMKIPSGLFIPSMAVGAIAGR+
Sbjct: 479 TSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRL 538
Query: 483 VGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFEL 542
+G+G+EQLAY+H +W +F +WC GADC+TPGLYAMVGAAACLGGVTRMTVSLVVIMFEL
Sbjct: 539 LGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFEL 598
Query: 543 TGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRP 602
TGGLEYIVPLMAAA+TSKWVADA G+EGIY+AHI LNGYPFL+ K+EF H+TLA DVM+P
Sbjct: 599 TGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKP 658
Query: 603 RRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNAR 662
RR +P L+VLTQDSMTVEDVET+I ET Y+GFPVVVSR+S+RL+GF RR+LI++I+NAR
Sbjct: 659 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENAR 718
Query: 663 QRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGL 722
++Q+G+VS SI+YFTE P LP +P LKLR IL+LSPFTVTD TPME VVDIFRKLGL
Sbjct: 719 KKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGL 778
Query: 723 RQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760
RQCLVT +GRLLGIITKKDVL+H+AQMANQDP+SI+FN
Sbjct: 779 RQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 1235 bits (3195), Expect = 0.0
Identities = 588/758 (77%), Positives = 674/758 (88%), Gaps = 1/758 (0%)
Query: 3 NAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIK 62
N G + S +MDFL+EP P VGTY+DF+TIDW+REKSRD DRHR+IT+KSKES W I
Sbjct: 60 NGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIH 119
Query: 63 SLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETT 122
S+ DA+SGW++MLLIGLL+G+LAG+ID++ WMTDLKEG+C FW++HE CCW S T
Sbjct: 120 SVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVT 179
Query: 123 FEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSG 182
FE+RDKCP W WS+L+++ EGA AYI+NY MY+LWALLFAFLAVSLV+VFAPYACGSG
Sbjct: 180 FEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSG 239
Query: 183 IPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLF 242
IPEIKTILSGFIIRGYLGKWTL+IKT+TLVL VSSGLSLGKEGPLVHVACCCGN F
Sbjct: 240 IPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCF 299
Query: 243 SKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 302
+KY KNE KRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
Sbjct: 300 NKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 359
Query: 303 FTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKT 362
FTLRSINPFGNSRLVLFYVE+HTPW++ EL PFILLG+FGGLWG LFIR NIAWCR+RKT
Sbjct: 360 FTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKT 419
Query: 363 TRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNM 422
T+LGKYPV+EV+VVTAITAI+A+PN YTR STSELISELFNDCG L+SS+LCDY N N
Sbjct: 420 TQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFN- 478
Query: 423 TRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRM 482
T ++PDRPAGVGVY+AMWQLAL LI KIV+TIFTFGMKIPSGLFIPSMAVGAIAGR+
Sbjct: 479 TSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRL 538
Query: 483 VGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFEL 542
+G+G+EQLAY+H +W +F +WC GADC+TPGLYAMVGAAACLGGVTRMTVSLVVIMFEL
Sbjct: 539 LGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFEL 598
Query: 543 TGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRP 602
TGGLEYIVPLMAAA+TSKWVADA G+EGIY+AHI LNGYPFL+ K+EF H+TLA DVM+P
Sbjct: 599 TGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKP 658
Query: 603 RRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNAR 662
RR +P L+VLTQDSMTVEDVET+I ET Y+GFPVVVSR+S+RL+GF RR+LI++I+NAR
Sbjct: 659 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENAR 718
Query: 663 QRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGL 722
++Q+G+VS SI+YFTE P LP +P LKLR IL+LSPFTVTD TPME VVDIFRKLGL
Sbjct: 719 KKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGL 778
Query: 723 RQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 760
RQCLVT +GRLLGIITKKDVL+H+AQMANQDP+SI+FN
Sbjct: 779 RQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 816
>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
Length = 746
Score = 1228 bits (3176), Expect = 0.0
Identities = 585/747 (78%), Positives = 669/747 (89%), Gaps = 1/747 (0%)
Query: 14 MDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSGWVV 73
MDFL+EP P VGTY+DF+TIDW+REKSRD DRHR+IT+KSKES W I S+ DA+SGW++
Sbjct: 1 MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLL 60
Query: 74 MLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQ 133
MLLIGLL+G+LAG+ID++ WMTDLKEG+C FW++HE CCW S TFE+RDKCP W
Sbjct: 61 MLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWN 120
Query: 134 KWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGF 193
WS+L+++ EGA AYI+NY MY+LWALLFAFLAVSLV+VFAPYACGSGIPEIKTILSGF
Sbjct: 121 SWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGF 180
Query: 194 IIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRR 253
IIRGYLGKWTL+IKT+TLVL VSSGLSLGKEGPLVHVACCCGN F+KY KNE KRR
Sbjct: 181 IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRR 240
Query: 254 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 313
EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN
Sbjct: 241 EVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGN 300
Query: 314 SRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLGKYPVLEV 373
SRLVLFYVE+HTPW++ EL PFILLG+FGGLWG LFIR NIAWCR+RKTT+LGKYPV+EV
Sbjct: 301 SRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEV 360
Query: 374 IVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRP 433
+VVTAITAI+A+PN YTR STSELISELFNDCG L+SS+LCDY N N T ++PDRP
Sbjct: 361 LVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFN-TSKGGELPDRP 419
Query: 434 AGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYH 493
AGVGVY+AMWQLAL LI KIV+TIFTFGMKIPSGLFIPSMAVGAIAGR++G+G+EQLAY+
Sbjct: 420 AGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYY 479
Query: 494 HHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLM 553
H +W +F +WC GADC+TPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLM
Sbjct: 480 HQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLM 539
Query: 554 AAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLT 613
AAA+TSKWVADA G+EGIY+AHI LNGYPFL+ K+EF H+TLA DVM+PRR +P L+VLT
Sbjct: 540 AAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLT 599
Query: 614 QDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSI 673
QDSMTVEDVET+I ET Y+GFPVVVSR+S+RL+GF RR+LI++I+NAR++Q+G+VS SI
Sbjct: 600 QDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSI 659
Query: 674 MYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRL 733
+YFTE P LP +P LKLR IL+LSPFTVTD TPME VVDIFRKLGLRQCLVT +GRL
Sbjct: 660 IYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRL 719
Query: 734 LGIITKKDVLRHMAQMANQDPESIMFN 760
LGIITKKDVL+H+AQMANQDP+SI+FN
Sbjct: 720 LGIITKKDVLKHIAQMANQDPDSILFN 746
>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
Length = 781
Score = 253 bits (647), Expect = 4e-67
Identities = 220/727 (30%), Positives = 338/727 (46%), Gaps = 115/727 (15%)
Query: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
WV+ LIG+L G +A ID+ V+ + LK V
Sbjct: 103 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI----------------------- 139
Query: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALL---FAFLAVSLVRVFAPYACGSGIPEIK 187
K++E +G ++ L +LWA L F + +V P A GSGIP+IK
Sbjct: 140 --DKFTE------KGGLSFSL-----LLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 186
Query: 188 TILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFS---- 243
L+G I + TL+IK ++L V GL++GKEGP++H S S
Sbjct: 187 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLK 246
Query: 244 ------KYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFA 297
+Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++ WR FFA
Sbjct: 247 RDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFA 306
Query: 298 ALVAAFTLR--------SINPFGNSRLVLF--YVEYHTPWYMAELFPFILLGVFGGLWGT 347
++++ FTL ++ + L+ F + + + E+ FI +GV GG+ G
Sbjct: 307 SMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGA 366
Query: 348 LFIRCNIAWCRRRKTTRLGK--YPVLEVIVVTAITAIIAYPNPYTRQSTSELIS------ 399
+F N W + + + V+E ++V A+TA +A+ Y+ + L
Sbjct: 367 VFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYP 425
Query: 400 -ELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIF 458
+LF G +S + N P + V D P T L L + + +
Sbjct: 426 LQLFCADGEY-NSMAAAFFNTPEKS-VVSLFHDPPGSYNPLT----LGLFTLVYFFLACW 479
Query: 459 TFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAM 518
T+G+ + +G+FIPS+ +GA GR+ GI + L A PG YA+
Sbjct: 480 TYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLT--------------GAAIWADPGKYAL 525
Query: 519 VGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHL 578
+GAAA LGG+ RMT+SL VIM E T + Y P+M +T+K V D F EG+Y+ HI L
Sbjct: 526 MGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQL 584
Query: 579 NGYPFLDVKDEFT-HRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLI-KETDYNGFPV 636
PFL + T H A +VM P++ L + V+ L +++NGFPV
Sbjct: 585 QSVPFLHWEAPVTSHSLTAREVM-----STPVTCLRRREKVGVIVDVLSDTASNHNGFPV 639
Query: 637 VVSRDS---ERLIGFAQRRELILAIKN---ARQRQEGIVSNSIMY--FTEEPPEL-PANS 687
V D RL G R +LI+ +K+ + G+V + F + P P S
Sbjct: 640 VEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQS 699
Query: 688 PH--------PLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVT-RSGRLLGIIT 738
H + L +N SP+TV + V +FR LGLR +V +++G++T
Sbjct: 700 IHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVT 759
Query: 739 KKDVLRH 745
+KD+ R+
Sbjct: 760 RKDLARY 766
>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
Length = 805
Score = 253 bits (647), Expect = 4e-67
Identities = 220/727 (30%), Positives = 338/727 (46%), Gaps = 115/727 (15%)
Query: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
WV+ LIG+L G +A ID+ V+ + LK V
Sbjct: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI----------------------- 163
Query: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALL---FAFLAVSLVRVFAPYACGSGIPEIK 187
K++E +G ++ L +LWA L F + +V P A GSGIP+IK
Sbjct: 164 --DKFTE------KGGLSFSL-----LLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
Query: 188 TILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFS---- 243
L+G I + TL+IK ++L V GL++GKEGP++H S S
Sbjct: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLK 270
Query: 244 ------KYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFA 297
+Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++ WR FFA
Sbjct: 271 RDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFA 330
Query: 298 ALVAAFTLR--------SINPFGNSRLVLF--YVEYHTPWYMAELFPFILLGVFGGLWGT 347
++++ FTL ++ + L+ F + + + E+ FI +GV GG+ G
Sbjct: 331 SMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGA 390
Query: 348 LFIRCNIAWCRRRKTTRLGK--YPVLEVIVVTAITAIIAYPNPYTRQSTSELIS------ 399
+F N W + + + V+E ++V A+TA +A+ Y+ + L
Sbjct: 391 VFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYP 449
Query: 400 -ELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIF 458
+LF G +S + N P + V D P T L L + + +
Sbjct: 450 LQLFCADGEY-NSMAAAFFNTPEKS-VVSLFHDPPGSYNPLT----LGLFTLVYFFLACW 503
Query: 459 TFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAM 518
T+G+ + +G+FIPS+ +GA GR+ GI + L A PG YA+
Sbjct: 504 TYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLT--------------GAAIWADPGKYAL 549
Query: 519 VGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHL 578
+GAAA LGG+ RMT+SL VIM E T + Y P+M +T+K V D F EG+Y+ HI L
Sbjct: 550 MGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQL 608
Query: 579 NGYPFLDVKDEFT-HRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLI-KETDYNGFPV 636
PFL + T H A +VM P++ L + V+ L +++NGFPV
Sbjct: 609 QSVPFLHWEAPVTSHSLTAREVM-----STPVTCLRRREKVGVIVDVLSDTASNHNGFPV 663
Query: 637 VVSRDS---ERLIGFAQRRELILAIKN---ARQRQEGIVSNSIMY--FTEEPPEL-PANS 687
V D RL G R +LI+ +K+ + G+V + F + P P S
Sbjct: 664 VEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQS 723
Query: 688 PH--------PLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVT-RSGRLLGIIT 738
H + L +N SP+TV + V +FR LGLR +V +++G++T
Sbjct: 724 IHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVT 783
Query: 739 KKDVLRH 745
+KD+ R+
Sbjct: 784 RKDLARY 790
>gi|156104869 chloride channel 2 [Homo sapiens]
Length = 898
Score = 220 bits (561), Expect = 3e-57
Identities = 181/620 (29%), Positives = 293/620 (47%), Gaps = 88/620 (14%)
Query: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
W+ ++L+GLL ++ V+D A+ CL A
Sbjct: 91 WIFLVLLGLLMALVSWVMDYAI--------AACLQA------------------------ 118
Query: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
Q+W +N S +L YL ++ + ++ + ++ AP A GSGIPE+KTIL
Sbjct: 119 --QQWMSRGLNTS-----ILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTIL 171
Query: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG---NFFSSLFSKYSK 247
G +++ YL T + K + L + SG+ LGKEGP VH+A C + F SLF +
Sbjct: 172 RGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYE 231
Query: 248 NEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRS 307
NE + E+L+AA A GV F APIGGVLFS+E S +F ++ WR FFAA +AF R
Sbjct: 232 NESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRV 291
Query: 308 I---NPFGNSRLVLFYVEYHT--PWYMAELFPFILLGVFGGLWGTLFIRCN---IAWCRR 359
+ N + LF + P+ + EL F ++G+ G G LF+ N + R+
Sbjct: 292 LAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRK 351
Query: 360 RKTTR--LGKYPVLEVIVVTAITAIIAYPNPY-----TRQSTSELISELFNDCGALESSQ 412
+KT L + +L +VT + + + +P + + S E + LF++ +
Sbjct: 352 QKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQG- 410
Query: 413 LCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPS 472
L + + P+ ++ + P V+ L + ++ K ++ + +P G F+P
Sbjct: 411 LVEELEPPSTSQAWN-----PPRANVFLT---LVIFILMKFWMSALATTIPVPCGAFMPV 462
Query: 473 MAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMT 532
+GA GR+VG E +A D I + PG YA+VGAAA G VT T
Sbjct: 463 FVIGAAFGRLVG---ESMAAWFPDGI----HTDSSTYRIVPGGYAVVGAAALAGAVTH-T 514
Query: 533 VSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTH 592
VS VI+FELTG + +I+P+M A + + VA + + +Y++ I + P+L H
Sbjct: 515 VSTAVIVFELTGQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRH 573
Query: 593 ---RTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFA 649
R D+M R P +++ S T D+ + T +V S +S L+G
Sbjct: 574 QQYRVRVEDIM--VRDVPHVAL----SCTFRDLRLALHRTKGRMLALVESPESMILLGSI 627
Query: 650 QRRELI----LAIKNARQRQ 665
+R +++ + AR+RQ
Sbjct: 628 ERSQVVALLGAQLSPARRRQ 647
Score = 35.0 bits (79), Expect = 0.26
Identities = 16/43 (37%), Positives = 25/43 (58%)
Query: 700 SPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDV 742
+PF + + T + IF LG+ VT GRL+GI+T K++
Sbjct: 793 APFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKEL 835
>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
Length = 869
Score = 217 bits (553), Expect = 3e-56
Identities = 191/625 (30%), Positives = 297/625 (47%), Gaps = 112/625 (17%)
Query: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
W+V+ IG+ G + +D V T LK GV + S E+C
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQT----SVEEC---------------- 120
Query: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
+G A L+ L + + L F FLA SL+ + P A GSGIPE+K L
Sbjct: 121 -----------SQKGCLA--LSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Query: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG----NFFSSLFSK-- 244
+G + G + TLL K + ++ V+ GL +GKEGP++H G F S K
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
Query: 245 ----YSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300
Y +++ +R+ +SA AAAGV+ AFGAPIGG LFSLEE S ++ W+ F ++
Sbjct: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286
Query: 301 AAFTLR------SINPFGNSRL--VLFYVEYHTP--------WYMAELFPFILLGVFGGL 344
A FTL +G+ +L +L + E+ W +L F+++GV GGL
Sbjct: 287 ATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGL 346
Query: 345 WGTLF--IRCNIAWCRRRKTTRLGK-YPVLEVIVVTAITAIIAYPNPYT----RQSTSEL 397
G F + +A R R K VLE ++V+ +T ++ + RQ +S
Sbjct: 347 LGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSS- 405
Query: 398 ISELFNDCGALESSQLCDYINDPNMT--RPVDDIPD------RPAGVGVYTAMWQ----- 444
S++ ND L Q+ + +N T P D D P + Q
Sbjct: 406 -SQIGNDSFQL---QVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFS 461
Query: 445 ---LALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFR 501
LAL + ++ +T+G+ +PSGLF+PS+ GA GR+V ++
Sbjct: 462 PVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYI---------- 511
Query: 502 NWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKW 561
G + G +A++GAAA LGGV RMT+SL VI+ E T + Y +P+M + +KW
Sbjct: 512 -----GLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKW 566
Query: 562 VADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTL-ATDVMRPRRGEPPLSVLTQDSMTVE 620
D F K GIY+ H+ L G P L+ + E L A+D+M EP L+ + + ++
Sbjct: 567 TGDFFNK-GIYDIHVGLRGVPLLEWETEVEMDKLRASDIM-----EPNLTYVYPHT-RIQ 619
Query: 621 DVETLIKETDYNGFPVVV-SRDSER 644
+ ++++ T ++ FPVV +R +E+
Sbjct: 620 SLVSILRTTVHHAFPVVTENRGNEK 644
Score = 38.9 bits (89), Expect = 0.018
Identities = 20/53 (37%), Positives = 33/53 (62%), Gaps = 1/53 (1%)
Query: 697 LNLSPFTVTDHTPMETVVDIFRKLGLRQC-LVTRSGRLLGIITKKDVLRHMAQ 748
+N SPFTV+ +T + V ++FR +GLR +V G ++GIIT+ ++ Q
Sbjct: 807 MNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQ 859
>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
Length = 988
Score = 201 bits (512), Expect = 2e-51
Identities = 174/605 (28%), Positives = 277/605 (45%), Gaps = 86/605 (14%)
Query: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
W+ ++L+GLL V W D L A+
Sbjct: 118 WIFLVLLGLLMAL--------VSWSMDYVSAKSLQAY----------------------- 146
Query: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
KWS + S L +L+++ + L+ + + +P A GSGIPE+KTIL
Sbjct: 147 ---KWSYAQMQPS-----LPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTIL 198
Query: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG---NFFSSLFSKYSK 247
G +++ YL + K V L + SG+ +GKEGP VH+A C + F S+F +
Sbjct: 199 RGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYE 258
Query: 248 NEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRS 307
++L+ A GV FG P+GGVLFS+E S YF ++ WR FFAA +AF R
Sbjct: 259 QPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRV 318
Query: 308 INPFGNSRL---VLFYVEYHT--PWYMAELFPFILLGVFGGLWGTLFI---RCNIAWCRR 359
+ + + LF + P+ + EL F +G+ GL G +F+ R + R+
Sbjct: 319 LAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRK 378
Query: 360 RKTTR--LGKYPVLEVIVVTAITAIIAYPNPYTRQSTSEL-----ISELFNDCGALESSQ 412
K L K+ +L +VT + A +P + EL IS LF +++
Sbjct: 379 HKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMPREAISTLF------DNNT 432
Query: 413 LCDYINDP-NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIP 471
+ DP ++ + I R V + + L + K ++I M IP G F+P
Sbjct: 433 WVKHAGDPESLGQSAVWIHPRVNVVII------IFLFFVMKFWMSIVATTMPIPCGGFMP 486
Query: 472 SMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRM 531
+GA GR+VG E +A D I+F + + PG YA++GAAA G V+
Sbjct: 487 VFVLGAAFGRLVG---EIMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH- 538
Query: 532 TVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVK--DE 589
TVS VI FELTG + +I+P+M A + + VA + + +Y++ I + P+L ++
Sbjct: 539 TVSTAVICFELTGQIAHILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQ 597
Query: 590 FTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFA 649
+ T+ + + R + S T ++ TL++ T P+V S+DS L+G
Sbjct: 598 LSKYTIFVEDIMVRDVK-----FVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSV 652
Query: 650 QRREL 654
+R EL
Sbjct: 653 ERSEL 657
Score = 30.4 bits (67), Expect = 6.4
Identities = 13/46 (28%), Positives = 25/46 (54%)
Query: 697 LNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDV 742
++ SPF + + T + +F LGL VT G+L G++ +++
Sbjct: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEEL 866
>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
Length = 686
Score = 194 bits (494), Expect = 2e-49
Identities = 170/638 (26%), Positives = 289/638 (45%), Gaps = 70/638 (10%)
Query: 144 EGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWT 203
E +++L YL + ++ + + + P + GSGIPE+KT+L+G I+ YL
Sbjct: 84 EIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKN 143
Query: 204 LLIKTVTLVLVVSSG--LSLGKEGPLVHVACCCGNFFSSLFSKY---SKNEGKRREVLSA 258
K V L +++G L LGK GP VH++ + + + +N+ K+ E+L A
Sbjct: 144 FGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVA 203
Query: 259 AAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR--- 315
AAA GV+ F AP GVLFS+E +S +F ++ WR FFAA AF R + F + +
Sbjct: 204 AAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETI 263
Query: 316 --LVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLG------K 367
L P+ + E+F F+ LG G+ ++ C + KT R
Sbjct: 264 TSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATS 323
Query: 368 YPVLEVIVVTAITAIIAYPNPY-----TRQSTSELISELFNDCGALESSQLCDYINDPNM 422
PV + T + A I YP +R S + + LF++ S L + P
Sbjct: 324 KPVYSAL-ATLLLASITYPPGVGHFLASRLSMKQHLDSLFDN----HSWALMTQNSSPPW 378
Query: 423 TRPVDDIPDRPAGV------GVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVG 476
+D P + +T LA L+ K + I + +P+G F+P +G
Sbjct: 379 PEELD-----PQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILG 433
Query: 477 AIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLV 536
A GR++G E LA + I+ P + PG YA+ GAAA G VT T+S
Sbjct: 434 AAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAVTH-TISTA 485
Query: 537 VIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLA 596
++ FELTG + + +P++ A + + +A + + Y+ I + P+L R +
Sbjct: 486 LLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYL---PRILGRNIG 541
Query: 597 TDVMRPRR-GEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELI 655
+ +R ++ L +D+ +E+V ++ TD +P+V S +S+ L+G QR +L+
Sbjct: 542 SHHVRVEHFMNHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV 600
Query: 656 LAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVT--DHTPMETV 713
A++ E P P + L R P T+T T +
Sbjct: 601 QALQ-----------------AEPPSRAPGHQCLQDILARGCPTEPVTLTLFSETTLHQA 643
Query: 714 VDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMAN 751
++F+ L L+ VT GR +G ++ ++ + ++ + N
Sbjct: 644 QNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681
>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
Length = 687
Score = 193 bits (491), Expect = 4e-49
Identities = 171/640 (26%), Positives = 290/640 (45%), Gaps = 73/640 (11%)
Query: 144 EGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWT 203
E +++L YL + ++ + + + P + GSGIPE+KT+L+G I+ YL
Sbjct: 84 EIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKN 143
Query: 204 LLIKTVTLVLVVSSG--LSLGKEGPLVHVACCCGNFFSSLFSKY---SKNEGKRREVLSA 258
K V L +++G L LGK GP VH++ + + + +N+ K+ E+L A
Sbjct: 144 FGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVA 203
Query: 259 AAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR--- 315
AAA GV+ F AP GVLFS+E +S +F ++ WR FFAA AF R + F + +
Sbjct: 204 AAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETI 263
Query: 316 --LVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLG------K 367
L P+ + E+F F+ LG G+ ++ C + KT R
Sbjct: 264 TSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATS 323
Query: 368 YPVLEVIVVTAITAIIAYPNPY-----TRQSTSELISELFNDCGALESSQLCDYINDPNM 422
PV + T + A I YP +R S + + LF++ S L + P
Sbjct: 324 KPVYSAL-ATLLLASITYPPGVGHFLASRLSMKQHLDSLFDN----HSWALMTQNSSPPW 378
Query: 423 TRPVDDIPDRPAGV------GVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVG 476
+D P + +T LA L+ K + I + +P+G F+P +G
Sbjct: 379 PEELD-----PQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILG 433
Query: 477 AIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLV 536
A GR++G E LA + I+ P + PG YA+ GAAA G VT T+S
Sbjct: 434 AAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAVTH-TISTA 485
Query: 537 VIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLA 596
++ FELTG + + +P++ A + + +A + + Y+ I + P+L R +
Sbjct: 486 LLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYL---PRILGRNIG 541
Query: 597 TDVMRPRR-GEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELI 655
+ +R ++ L +D+ +E+V ++ TD +P+V S +S+ L+G QR +L+
Sbjct: 542 SHHVRVEHFMNHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV 600
Query: 656 LAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLK--LRRILNLSPFTVT--DHTPME 711
A++ EPP L+ L R P T+T T +
Sbjct: 601 QALQ------------------AEPPSRAPGHQQCLQDILARGCPTEPVTLTLFSETTLH 642
Query: 712 TVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMAN 751
++F+ L L+ VT GR +G ++ ++ + ++ + N
Sbjct: 643 QAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 682
>gi|155969705 chloride channel Kb [Homo sapiens]
Length = 687
Score = 186 bits (471), Expect = 9e-47
Identities = 171/647 (26%), Positives = 287/647 (44%), Gaps = 87/647 (13%)
Query: 144 EGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWT 203
E +++L YL + ++ + + + P + GSGIPE+KT+L+G ++ YL
Sbjct: 84 EIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKN 143
Query: 204 LLIKTVTL--VLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKY---SKNEGKRREVLSA 258
K V L L S L LGK GP VH++ + + + +N+ K+ E+L A
Sbjct: 144 FGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVA 203
Query: 259 AAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR--- 315
AAA GV+ F AP GVLFS+E +S +F + WR FFAA AF R + F + +
Sbjct: 204 AAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETI 263
Query: 316 --LVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRC---------NIAWCRRRKTTR 364
L P+ + E+F F+ LG G+ G+ ++ C N + + T
Sbjct: 264 TSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATS 323
Query: 365 LGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTR 424
Y L +V+ +IT YP R S L + D L D + MT+
Sbjct: 324 KPVYSALATLVLASIT----YPPSAGRFLASRLSMKQHLD-------SLFDNHSWALMTQ 372
Query: 425 PVDDIPDRPAGVGVYTAMWQ-----------LALALIFKIVVTIFTFGMKIPSGLFIPSM 473
+ P P + W+ LA L+ K + I + +P+G F+P
Sbjct: 373 --NSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIF 430
Query: 474 AVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTV 533
GA GR+ G E L++ + I+ P + PG YA+ GAAA G VT T+
Sbjct: 431 VYGAAIGRLFG---ETLSFIFPEGIVAGGITNP----IMPGGYALAGAAAFSGAVTH-TI 482
Query: 534 SLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLD---VKDEF 590
S ++ FE+TG + + +P++ A + + +A + + Y+ + + P+L ++
Sbjct: 483 STALLAFEVTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTVIVKKLPYLPRILGRNIG 541
Query: 591 THRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQ 650
+HR M ++ L +D M +E+V ++ TD +P+V S +S+ L+G +
Sbjct: 542 SHRVRVEHFM-----NHSITTLAKD-MPLEEVVKVVTSTDVAKYPLVESTESQILVGIVR 595
Query: 651 RRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRIL----NLSPFT--V 704
R +L+ A+K EPP H L+ IL P T +
Sbjct: 596 RAQLVQALK------------------AEPPSWAPG--HQQCLQDILAAGCPTEPVTLKL 635
Query: 705 TDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMAN 751
+ T + ++F L L VT GR +G ++ ++ + ++ + N
Sbjct: 636 SPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTN 682
>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
Length = 353
Score = 114 bits (285), Expect = 3e-25
Identities = 85/245 (34%), Positives = 121/245 (49%), Gaps = 44/245 (17%)
Query: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
W+V+ IG+ G + +D V T LK GV + S E+C
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQT----SVEEC---------------- 120
Query: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
+G A L+ L + + L F FLA SL+ + P A GSGIPE+K L
Sbjct: 121 -----------SQKGCLA--LSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Query: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG----NFFSSLFSK-- 244
+G + G + TLL K + ++ V+ GL +GKEGP++H G F S K
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
Query: 245 ----YSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 300
Y +++ +R+ +SA AAAGV+ AFGAPIGG LFSLEE S ++ W+ F ++
Sbjct: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286
Query: 301 AAFTL 305
A FTL
Sbjct: 287 ATFTL 291
>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
Length = 308
Score = 66.2 bits (160), Expect = 1e-10
Identities = 52/165 (31%), Positives = 76/165 (46%), Gaps = 34/165 (20%)
Query: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
W+V+ IG+ G + +D V T LK GV + S E+C
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQT----SVEEC---------------- 120
Query: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
+G A L+ L + + L F FLA SL+ + P A GSGIPE+K L
Sbjct: 121 -----------SQKGCLA--LSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Query: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG 235
+G + G + TLL K + ++ V+ GL +GKEGP++H G
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVG 211
>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
Length = 320
Score = 66.2 bits (160), Expect = 1e-10
Identities = 52/165 (31%), Positives = 76/165 (46%), Gaps = 34/165 (20%)
Query: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
W+V+ IG+ G + +D V T LK GV + S E+C
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQT----SVEEC---------------- 120
Query: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
+G A L+ L + + L F FLA SL+ + P A GSGIPE+K L
Sbjct: 121 -----------SQKGCLA--LSLLELLGFNLTFVFLA-SLLVLIEPVAAGSGIPEVKCYL 166
Query: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG 235
+G + G + TLL K + ++ V+ GL +GKEGP++H G
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVG 211
>gi|117606362 anterior pharynx defective 1 homolog A isoform 1 [Homo
sapiens]
Length = 265
Score = 32.0 bits (71), Expect = 2.2
Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 6/66 (9%)
Query: 314 SRLVLFYVEYHTPWYMAELFPFILLGVFGGLW------GTLFIRCNIAWCRRRKTTRLGK 367
S L+ + + PWY A L P + V GLW G+L CRR++ +R+
Sbjct: 196 SHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCRRQEDSRVMV 255
Query: 368 YPVLEV 373
Y L +
Sbjct: 256 YSALRI 261
>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
Length = 412
Score = 31.6 bits (70), Expect = 2.9
Identities = 21/53 (39%), Positives = 23/53 (43%), Gaps = 17/53 (32%)
Query: 478 IAGRMVGIGVEQLAYHHHD--------W--IIFRNWC-------RPGADCVTP 513
I G V + V L YHHHD W +I NWC RPG D V P
Sbjct: 213 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 265
>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
Length = 321
Score = 31.6 bits (70), Expect = 2.9
Identities = 21/53 (39%), Positives = 23/53 (43%), Gaps = 17/53 (32%)
Query: 478 IAGRMVGIGVEQLAYHHHD--------W--IIFRNWC-------RPGADCVTP 513
I G V + V L YHHHD W +I NWC RPG D V P
Sbjct: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 174
>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
sapiens]
Length = 502
Score = 31.6 bits (70), Expect = 2.9
Identities = 21/53 (39%), Positives = 23/53 (43%), Gaps = 17/53 (32%)
Query: 478 IAGRMVGIGVEQLAYHHHD--------W--IIFRNWC-------RPGADCVTP 513
I G V + V L YHHHD W +I NWC RPG D V P
Sbjct: 303 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 355
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 30.8 bits (68), Expect = 4.9
Identities = 46/195 (23%), Positives = 75/195 (38%), Gaps = 26/195 (13%)
Query: 127 DKCPLWQKWSELLV---NQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGI 183
D C + + WS L N+ I+ + ++ L F FL + + P
Sbjct: 1105 DWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGST 1164
Query: 184 PEIKTILSGFIIRG-YLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLF 242
I +S +I ++G+ TL VVS GL G++ + L
Sbjct: 1165 ERIFLTVSNYIFTAIFVGEMTLK--------VVSLGLYFGEQ--------------AYLR 1202
Query: 243 SKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 302
S ++ +G V ++ A GA I GVL L + PL+ + R+ LV
Sbjct: 1203 SSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE 1262
Query: 303 FTLRSINPFGNSRLV 317
+ S+ P GN L+
Sbjct: 1263 TLISSLKPIGNIVLI 1277
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 30.8 bits (68), Expect = 4.9
Identities = 46/195 (23%), Positives = 75/195 (38%), Gaps = 26/195 (13%)
Query: 127 DKCPLWQKWSELLV---NQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGI 183
D C + + WS L N+ I+ + ++ L F FL + + P
Sbjct: 1140 DWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGST 1199
Query: 184 PEIKTILSGFIIRG-YLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLF 242
I +S +I ++G+ TL VVS GL G++ + L
Sbjct: 1200 ERIFLTVSNYIFTAIFVGEMTLK--------VVSLGLYFGEQ--------------AYLR 1237
Query: 243 SKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 302
S ++ +G V ++ A GA I GVL L + PL+ + R+ LV
Sbjct: 1238 SSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE 1297
Query: 303 FTLRSINPFGNSRLV 317
+ S+ P GN L+
Sbjct: 1298 TLISSLKPIGNIVLI 1312
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,023,434
Number of Sequences: 37866
Number of extensions: 1201398
Number of successful extensions: 3711
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3628
Number of HSP's gapped (non-prelim): 35
length of query: 760
length of database: 18,247,518
effective HSP length: 110
effective length of query: 650
effective length of database: 14,082,258
effective search space: 9153467700
effective search space used: 9153467700
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.