Search of human proteins with 148806908

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148806908 fibronectin type III domain containing 1 [Homo
sapiens]
         (1894 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148806908 fibronectin type III domain containing 1 [Homo sapi...  3854   0.0  
gi|33667044 ABI gene family, member 3 (NESH) binding protein [Ho...   316   1e-85
gi|157311649 neogenin homolog 1 [Homo sapiens]                        155   4e-37
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]           150   9e-36
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        99   3e-20
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [...    98   7e-20
gi|83281200 protogenin [Homo sapiens]                                  94   1e-18
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   92   4e-18
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    92   4e-18
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   87   1e-16
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   87   1e-16
gi|163965366 nascent polypeptide-associated complex alpha subuni...    85   8e-16
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    83   3e-15
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    83   3e-15
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    83   3e-15
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    83   3e-15
gi|239743293 PREDICTED: mucin 12 [Homo sapiens]                        79   5e-14
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         77   1e-13
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...    77   2e-13
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap...    77   2e-13
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...    77   2e-13
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...    77   2e-13
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    77   2e-13
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    76   4e-13
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    76   4e-13
gi|116284392 mucin 2 precursor [Homo sapiens]                          75   6e-13
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi...    74   1e-12
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    74   1e-12
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]     73   2e-12
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]                73   3e-12

>gi|148806908 fibronectin type III domain containing 1 [Homo sapiens]
          Length = 1894

 Score = 3854 bits (9995), Expect = 0.0
 Identities = 1894/1894 (100%), Positives = 1894/1894 (100%)

Query: 1    MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWD 60
            MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWD
Sbjct: 1    MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWD 60

Query: 61   PPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVS 120
            PPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVS
Sbjct: 61   PPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVS 120

Query: 121  RPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAP 180
            RPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAP
Sbjct: 121  RPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAP 180

Query: 181  RLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGR 240
            RLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGR
Sbjct: 181  RLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGR 240

Query: 241  SQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVR 300
            SQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVR
Sbjct: 241  SQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVR 300

Query: 301  YREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPT 360
            YREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPT
Sbjct: 301  YREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPT 360

Query: 361  TAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSA 420
            TAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSA
Sbjct: 361  TAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSA 420

Query: 421  LVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSP 480
            LVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSP
Sbjct: 421  LVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSP 480

Query: 481  SPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEI 540
            SPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEI
Sbjct: 481  SPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEI 540

Query: 541  TGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKP 600
            TGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKP
Sbjct: 541  TGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKP 600

Query: 601  GFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPK 660
            GFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPK
Sbjct: 601  GFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPK 660

Query: 661  GAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLS 720
            GAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLS
Sbjct: 661  GAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLS 720

Query: 721  PPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEG 780
            PPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEG
Sbjct: 721  PPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEG 780

Query: 781  AEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRG 840
            AEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRG
Sbjct: 781  AEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRG 840

Query: 841  PRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ 900
            PRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ
Sbjct: 841  PRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ 900

Query: 901  PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADT 960
            PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADT
Sbjct: 901  PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADT 960

Query: 961  EGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQ 1020
            EGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQ
Sbjct: 961  EGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQ 1020

Query: 1021 SRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYD 1080
            SRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYD
Sbjct: 1021 SRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYD 1080

Query: 1081 DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR 1140
            DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR
Sbjct: 1081 DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR 1140

Query: 1141 PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV 1200
            PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV
Sbjct: 1141 PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV 1200

Query: 1201 PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR 1260
            PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR
Sbjct: 1201 PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR 1260

Query: 1261 LPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSY 1320
            LPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSY
Sbjct: 1261 LPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSY 1320

Query: 1321 RQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNP 1380
            RQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNP
Sbjct: 1321 RQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNP 1380

Query: 1381 LRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVI 1440
            LRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVI
Sbjct: 1381 LRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVI 1440

Query: 1441 KKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTT 1500
            KKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTT
Sbjct: 1441 KKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTT 1500

Query: 1501 TTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVI 1560
            TTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVI
Sbjct: 1501 TTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVI 1560

Query: 1561 YDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNK 1620
            YDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNK
Sbjct: 1561 YDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNK 1620

Query: 1621 DPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDK 1680
            DPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDK
Sbjct: 1621 DPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDK 1680

Query: 1681 ATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGP 1740
            ATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGP
Sbjct: 1681 ATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGP 1740

Query: 1741 ISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVL 1800
            ISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVL
Sbjct: 1741 ISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVL 1800

Query: 1801 CNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYR 1860
            CNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYR
Sbjct: 1801 CNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYR 1860

Query: 1861 QYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW 1894
            QYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW
Sbjct: 1861 QYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW 1894


>gi|33667044 ABI gene family, member 3 (NESH) binding protein [Homo
            sapiens]
          Length = 1075

 Score =  316 bits (810), Expect = 1e-85
 Identities = 236/674 (35%), Positives = 314/674 (46%), Gaps = 86/674 (12%)

Query: 1239 PVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAP--PGHFSTTPML 1296
            P +RP P PP + P  +         SA T++P     P P +TT AP      S  P +
Sbjct: 470  PKRRPRPKPPRTKPERT--------TSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKI 521

Query: 1297 SLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPN-GQRIINGPQGT- 1354
             L   + H +   P  +Q  R   +   + RP +     P +   P   QR+   P+ + 
Sbjct: 522  PLSPEVTHTK---PAPKQTPRAPPKPKTSPRPRI-----PQTQPVPKVPQRVTAKPKTSP 573

Query: 1355 ----KWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFG 1410
                 +     + ++L  +  Y + S   P  ++  G       +   P++SP       
Sbjct: 574  SPEVSYTTPAPKDVLLPHKP-YPEVSQSEPAPLETRG-------IPFIPMISPSP----S 621

Query: 1411 QGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTT 1470
            Q    T L             +P         TT  P TT    TT  P    TT RP T
Sbjct: 622  QEELQTTLEETDQST-----QEPF--------TTKIPRTTELAKTTQAPHRFYTTVRPRT 668

Query: 1471 ATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSS 1530
            +         +   R P+   R  +  +T  T  P T  P  PP    R        +  
Sbjct: 669  SDKPHIRPGVKQAPR-PSGADRNVSVDSTHPTKKPGTRRPPLPP----RPTHPRRKPLPP 723

Query: 1531 NGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPP-TTTEPSTTATTPRVIP 1589
            N +      +   +G+ +   + T              T RP  T  E   T      +P
Sbjct: 724  NNV----TGKPGSAGIISSGPITTPPLR---------STPRPTGTPLERIETDIKQPTVP 770

Query: 1590 EEGA-------ISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDE 1642
              G         SS P  E D  G+ RF  P+V Y+ K  ++PCS+TD++  F  +   E
Sbjct: 771  ASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATE 830

Query: 1643 IIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIR 1702
                    +  PPQ+ P N+TVV VEGC SFVI+DW+K    D VT Y V S     F  
Sbjct: 831  ------GNATSPPQNPPTNLTVVTVEGCPSFVILDWEKPL-NDTVTEYEVISRENGSFSG 883

Query: 1703 NKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRP-- 1760
               S Q ++ T   +ENLKPNT Y F+V+ +NP G GP+S +V+F TES +P  V  P  
Sbjct: 884  KNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPR-VSEPVS 942

Query: 1761 PGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYS 1820
             G + IW    F  D SY++C G+QYVKRTWY+KFVGV LCNSLRYKIYLSD+L   FY+
Sbjct: 943  AGRDAIWTERPFNSD-SYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYN 1001

Query: 1821 IGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYY 1880
            IGD  G GEDHCQFVDS LDGRTG Q   + LP  +GY+R  RQEPV+FG IG  T   Y
Sbjct: 1002 IGDQRGHGEDHCQFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINY 1061

Query: 1881 VGWYECGVSIPGKW 1894
            V WYECG +IPGKW
Sbjct: 1062 VQWYECGTTIPGKW 1075



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 184/886 (20%), Positives = 312/886 (35%), Gaps = 148/886 (16%)

Query: 162 LRVRVRSSDDRLSVAWKAPRLSGAKSPR-RSRGFLLGYGESGRKMNYVPLTRDER-THEI 219
           L+V + ++ D + + +  P      SP  +  G LLGYG +     Y PL  + + T  I
Sbjct: 39  LKVHINTTSDSILLKFLRP------SPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAI 92

Query: 220 KKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVS 279
                + + VV      SQ            K+  S +     P  + V  ++  SV +S
Sbjct: 93  VDAEPKYLIVVRPAPPPSQ------------KKSCSGKTRSRKPLQLVVGTLTPSSVFLS 140

Query: 280 WVDPVLEKQKKVVAS-----RQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFA 334
           W   +       + S     R YT+RYREK +  +W ++       ++ENL P+TVYEF 
Sbjct: 141 WGFLINPHHDWTLPSHCPNDRFYTIRYREKDKEKKWIFQICPATETIVENLKPNTVYEFG 200

Query: 335 VRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKE 394
           V+       G WS     +T   +            VNGK   + +++D        V  
Sbjct: 201 VK--DNVEGGIWSKIFNHKTVVGSK----------KVNGK---IQSTYDQDHTVPAYVPR 245

Query: 395 YIL-----------------SYAPALKPFGAKSLTY---PG--DTTSALVDGLQPGERYL 432
            ++                 + +P   P G   L +   PG  +TT  L   L      +
Sbjct: 246 KLIPITIIKQVIQNVTHKDSAKSPEKAPLGGVILVHLIIPGLNETTVKLPASL------M 299

Query: 433 FKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPS 492
           F+I    +  L   +K   +A+P  SK               PE    S R P +    +
Sbjct: 300 FEISDALKTQL---AKNETLALPAESKT--------------PEVEKISAR-PTTVTPET 341

Query: 493 VPASPQGRNAKDLLLDLKNKILANGGAPRKPQL--RAKKAEELDLQSTEITGEEELGS-- 548
           VP S +   +    LD+    LA+     KP +   AK +E+  +   +    +   S  
Sbjct: 342 VPRSTKPTTSS--ALDVSETTLASS---EKPWIVPTAKISEDSKVLQPQTATYDVFSSPT 396

Query: 549 -REDSPMSPSDTQDQKRTLRP-PSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLAT 606
             ++  +S S T    R L   P +   ++  P  T   +  P +P++  +        T
Sbjct: 397 TSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPT 456

Query: 607 QPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHP-KGAF-- 663
            P P    S  ++P      +    +P    S        S   E    +  P K  F  
Sbjct: 457 TPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFIS 516

Query: 664 AQPRPALSPS--------RQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAP 715
            +P+  LSP         +Q+P +  + ++S  P      P  + P    A+  +S S  
Sbjct: 517 LKPKIPLSPEVTHTKPAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPE 576

Query: 716 PSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRT 775
            S  +P       LLP +P+     S      E AP      P    +S S      S+ 
Sbjct: 577 VSYTTP--APKDVLLPHKPYPEVSQS------EPAPLETRGIPFIPMISPS-----PSQE 623

Query: 776 QVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHL-----LRHKPFAANGR 830
           ++    E +D        +E    +   T +  +   A   F+         KP    G 
Sbjct: 624 ELQTTLEETD-----QSTQEPFTTKIPRTTELAKTTQAPHRFYTTVRPRTSDKPHIRPGV 678

Query: 831 SPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVV 890
             +    G    +   S+  +  P    P +P    +HP+    +  +    KP  A ++
Sbjct: 679 KQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPR-PTHPR-RKPLPPNNVTGKPGSAGII 736

Query: 891 ND---------HVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGK 941
           +            P  +  P+ R   D+++ P   AS    E I +   S   +T P GK
Sbjct: 737 SSGPITTPPLRSTPRPTGTPLERIETDIKQ-PTVPASGEELENITDFSSSPTRETDPLGK 795

Query: 942 YSSLASKAQDVQQSTDA-----DTEGHSPKAQPGSTDRHASPARPP 982
                   + +Q+  ++     D+    PK +    +  + P  PP
Sbjct: 796 PRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATEGNATSPPQNPP 841



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 77/342 (22%), Positives = 134/342 (39%), Gaps = 38/342 (11%)

Query: 849  PQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSS-SRQPISRGWE 907
            P++T+     P VP   +        I    E +   PA      +PS+  R+P  +   
Sbjct: 429  PRATLAPSETPFVPQKLE--------IFTSPEMQPTTPAPQQTTSIPSTPKRRPRPK--- 477

Query: 908  DLRRSPQRGASLHRKEP-IPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPK 966
              R  P+R  S     P I ++P+ T     P GK   ++ K + +  S +      +PK
Sbjct: 478  PPRTKPERTTSAGTITPKISKSPEPTWTTPAP-GKTQFISLKPK-IPLSPEVTHTKPAPK 535

Query: 967  AQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGR 1026
              P +  +  +  RP   ++Q  P VP+R+T    P+  P P V+    +  P  +D   
Sbjct: 536  QTPRAPPKPKTSPRPRIPQTQPVPKVPQRVT--AKPKTSPSPEVS----YTTPAPKDV-L 588

Query: 1027 SPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDD---S 1083
             P +P   ++Q+  P P              + S+  L T L+  D+  Q  +      +
Sbjct: 589  LPHKPYPEVSQS-EPAPLETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRT 647

Query: 1084 TEVEAQDVRAPAH-----AARAKEAAASLPKHQQVESPTGA----GAGGDHRSQRGHAAS 1134
            TE+ A+  +AP         R  +     P  +Q   P+GA         H +++     
Sbjct: 648  TEL-AKTTQAPHRFYTTVRPRTSDKPHIRPGVKQAPRPSGADRNVSVDSTHPTKKPGTRR 706

Query: 1135 PARPSRPGGPQSRARVPSRAA--PGKSEPPSKRPLSSKSQQS 1174
            P  P RP  P+ +   P+     PG +   S  P+++   +S
Sbjct: 707  PPLPPRPTHPRRKPLPPNNVTGKPGSAGIISSGPITTPPLRS 748



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 23/60 (38%), Positives = 28/60 (46%), Gaps = 3/60 (5%)

Query: 1451 MQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIP 1510
            MQPTT   P P  TT  P+T   R      RT   R T+    T + + +  PT TTP P
Sbjct: 453  MQPTT---PAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAP 509



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 31/102 (30%), Positives = 43/102 (42%), Gaps = 4/102 (3%)

Query: 357 SAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGD 416
           S P   P NL V  V G P+ V   W+  P  +   +  ++S          KS+     
Sbjct: 835 SPPQNPPTNLTVVTVEGCPSFVILDWEK-PLNDTVTEYEVISRENGSFSGKNKSIQMTNQ 893

Query: 417 TTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTS 458
           T S  V+ L+P   Y F+++  N  G GP S    VA  T S
Sbjct: 894 TFST-VENLKPNTSYEFQVKPKNPLGEGPVSNT--VAFSTES 932



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 41/157 (26%), Positives = 64/157 (40%), Gaps = 33/157 (21%)

Query: 1137 RPSRPGGPQSRARVPS--RAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKED 1194
            +P+ P  PQ    +PS  +  P + +PP  +P  + S  +++ +                
Sbjct: 454  QPTTPA-PQQTTSIPSTPKRRP-RPKPPRTKPERTTSAGTITPK---------------- 495

Query: 1195 LLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLP---PPPGSS 1251
            +  S  P W   +TP  GK    SL     +P I L+P      P  +  P   P P +S
Sbjct: 496  ISKSPEPTW---TTPAPGKTQFISL-----KPKIPLSPEVTHTKPAPKQTPRAPPKPKTS 547

Query: 1252 PRASHVPSRLPPRSAATVSPVAGTHPWPQ--YTTRAP 1286
            PR     ++  P+    V+    T P P+  YTT AP
Sbjct: 548  PRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAP 584


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  155 bits (392), Expect = 4e-37
 Identities = 128/491 (26%), Positives = 212/491 (43%), Gaps = 56/491 (11%)

Query: 43   PRHVKL-LSTKMGLKVTWDPPKDATSR-PVEHYNIAYGKSLKSLKYIK--VNAETYSFLI 98
            P+++ L +     + + W PP  AT    +  Y I Y K+ +     +  V+    S LI
Sbjct: 637  PQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLI 696

Query: 99   EDVEPGVVYFVLLTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVP 158
            E ++ G  Y   + A   +G           P  +W+  +         F   + E  VP
Sbjct: 697  EGLDRGTEYNFRVAALTINGTG---------PATDWLSAE--------TFESDLDETRVP 739

Query: 159  NKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHE 218
              P  + VR     + V+W  P           RG+ +GYG        + +   +R + 
Sbjct: 740  EVPSSLHVRPLVTSIVVSWTPPENQNIVV----RGYAIGYGIGSPHAQTIKVDYKQRYYT 795

Query: 219  IKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELD----------VPDD--- 265
            I+ L   S YV++L++ N+ G   P+Y +A+T R  ++  E+D          VPD    
Sbjct: 796  IENLDPSSHYVITLKAFNNVGEGIPLYESAVT-RPHTDTSEVDLFVINAPYTPVPDPTPM 854

Query: 266  -----ISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQI--ANR 318
                 +   ++S  ++ ++W D  L K +K+  SR YTVR++     A   YK       
Sbjct: 855  MPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIP-ANTKYKNANATTL 913

Query: 319  RVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVV 378
              L+  L P+T+YEF+V +++G R   WS +    T E  PT+ P+++ V    GKP  +
Sbjct: 914  SYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTI 973

Query: 379  AASWDALPETEGKVKEYILSYAPALKPFGAKSLTYP--GDTTSALVDGLQPGERYLFKIR 436
              +W    E  GK+  YI+ Y+  +       +  P  G+  +  +  L     Y FKI+
Sbjct: 974  IVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQ 1033

Query: 437  ATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEK----PEPSS--PSPRAPASSQH 490
            A N +G+GP S+A     P    +D   N + +G   K    P+  S    P + ++S H
Sbjct: 1034 ARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPH 1093

Query: 491  PSVPASPQGRN 501
             S P SP   N
Sbjct: 1094 GS-PTSPLDSN 1103



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 60/260 (23%), Positives = 100/260 (38%), Gaps = 20/260 (7%)

Query: 219 IKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPD---DISVRVMSSQS 275
           I+ L   +VY+  + + N  G  +     +    ++  + E+ +P    ++     S  S
Sbjct: 500 IQNLMPATVYIFRVMAQNKHGSGE-----SSAPLRVETQPEVQLPGPAPNLRAYAASPTS 554

Query: 276 VLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAV 335
           + V+W  PV    +     + Y + Y EKG     D   +++    I  L   T Y F V
Sbjct: 555 ITVTWETPVSGNGE----IQNYKLYYMEKGTDKEQDV-DVSSHSYTINGLKKYTEYSFRV 609

Query: 336 RISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEY 395
                   G  +  V  RT    P+ AP+NL++   N K  ++     A     G++  Y
Sbjct: 610 VAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGY 669

Query: 396 ILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMP 455
            + Y  A +          G   S L++GL  G  Y F++ A    G GP       A  
Sbjct: 670 KIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGP-------ATD 722

Query: 456 TTSKADVEQNTEDNGKPEKP 475
             S    E + ++   PE P
Sbjct: 723 WLSAETFESDLDETRVPEVP 742



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 35/102 (34%), Positives = 60/102 (58%), Gaps = 5/102 (4%)

Query: 1652 DLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGD-VVTGYLVYSASYEDFIRNKWSTQ-- 1708
            +L P   P+++TVV+ EG    +IV+W   +  +  +TGY++Y ++  +   + W  +  
Sbjct: 951  ELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPV 1010

Query: 1709 -ASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVT 1749
              + +TH  I+ L  +T YYFK+QA+N  G GP+S +V F T
Sbjct: 1011 VGNRLTH-QIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 56/230 (24%), Positives = 100/230 (43%), Gaps = 15/230 (6%)

Query: 263 PDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIAN---RR 319
           P D+   ++S++ + ++W  P  +     +    Y+V Y ++G +AR   +  ++    +
Sbjct: 442 PRDVVASLVSTRFIKLTWRTPASDPHGDNLT---YSVFYTKEG-IARERVENTSHPGEMQ 497

Query: 320 VLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRT-PE-SAPTTAPENLNVWPVNGKPTV 377
           V I+NL+P TVY F V        G+ S  +   T PE   P  AP NL  +  +  PT 
Sbjct: 498 VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAP-NLRAYAAS--PTS 554

Query: 378 VAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRA 437
           +  +W+      G+++ Y L Y   ++    K       + S  ++GL+    Y F++ A
Sbjct: 555 ITVTWETPVSGNGEIQNYKLYY---MEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVA 611

Query: 438 TNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPAS 487
            N+ G G  +    V   +   +   QN     +  K       P APA+
Sbjct: 612 YNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPAT 661



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 35/115 (30%), Positives = 49/115 (42%), Gaps = 11/115 (9%)

Query: 1654 PPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASY--EDFIRNKW-STQAS 1710
            P   APR++    V     F+ + W +    D     L YS  Y  E   R +  +T   
Sbjct: 437  PLPSAPRDVVASLVST--RFIKLTW-RTPASDPHGDNLTYSVFYTKEGIARERVENTSHP 493

Query: 1711 SVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEP 1765
                + I+NL P T Y F+V AQN HG G  S  +   T+ +     V+ PG  P
Sbjct: 494  GEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPE-----VQLPGPAP 543



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 4/82 (4%)

Query: 1674 VIVDWDKATPGD-VVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQA 1732
            + V W+    G+  +  Y +Y   Y +   +K      S     I  LK  T Y F+V A
Sbjct: 555  ITVTWETPVSGNGEIQNYKLY---YMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVA 611

Query: 1733 QNPHGYGPISPSVSFVTESDNP 1754
             N HG G  +P V+  T SD P
Sbjct: 612  YNKHGPGVSTPDVAVRTLSDVP 633



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 35/140 (25%), Positives = 51/140 (36%), Gaps = 13/140 (9%)

Query: 683  DRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHG---GSSRLLPTQPHLSSP 739
            D  S   G +   P    P      +   ++ P   L  PH     SS   P + HL  P
Sbjct: 1222 DSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHP 1281

Query: 740  -------LSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDG 792
                    S    D  ++  +  N PS  TM +S S    +  Q  EGA +S   S+   
Sbjct: 1282 GSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSS---SYLAS 1338

Query: 793  DREDGGRQAEATAQTLRARP 812
             +E+   Q+  TA    + P
Sbjct: 1339 SQEEDSGQSLPTAHVRPSHP 1358


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score =  150 bits (380), Expect = 9e-36
 Identities = 117/432 (27%), Positives = 189/432 (43%), Gaps = 50/432 (11%)

Query: 43   PRHVKL-LSTKMGLKVTWDPPKDATSRP-VEHYNIAYGKSLKSLKYIKVNAETYSFLIED 100
            P++V L +     +KV+W PP   T    +  Y I + K+ +  +   +      +L   
Sbjct: 626  PQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTG 685

Query: 101  VEPGVVYFVLLTAENHSGVSRPV--YRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVP 158
            +E G  Y   ++A   +G   P   Y AE+P                      + E +VP
Sbjct: 686  LEKGSQYSFQVSAMTVNGTGPPSNWYTAETP-------------------ENDLDESQVP 726

Query: 159  NKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHE 218
            ++P  + VR   + + ++W  P           RG+++GYG        V +   +R + 
Sbjct: 727  DQPSSLHVRPQTNCIIMSWTPPLNPNIVV----RGYIIGYGVGSPYAETVRVDSKQRYYS 782

Query: 219  IKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELD-----------VPD--- 264
            I++L S S YV+SL++ N+ G   P+Y +A T+      D +D           VPD   
Sbjct: 783  IERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLST 842

Query: 265  ------DISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREK-GELARWDYKQIAN 317
                   +    ++  +V VSW D  + K +K    R YTVR+R      A++  +   +
Sbjct: 843  PMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTS 902

Query: 318  RRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTV 377
                   L P+T+YEF+V +++  R   WS +    T E+APT+AP++L V    GKP  
Sbjct: 903  LSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRA 962

Query: 378  VAASWDALPETEGKVKEYILSYAPALK-PFGAKSL-TYPGDTTSALVDGLQPGERYLFKI 435
            V  SW    E  GK+  YIL Y      P     + T  GD  +  +  L     Y F+I
Sbjct: 963  VIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRI 1022

Query: 436  RATNRRGLGPHS 447
            +A N +G+GP S
Sbjct: 1023 QARNSKGVGPLS 1034



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 32/99 (32%), Positives = 53/99 (53%), Gaps = 5/99 (5%)

Query: 1655 PQHAPRNITVVAVEGCHSFVIVDWDKATPGD-VVTGYLVYSASYEDFIRNKWSTQASS-- 1711
            P  AP+++TV+  EG    VIV W      +  +T Y+++    ++   + W  +  S  
Sbjct: 944  PTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGD 1003

Query: 1712 -VTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVT 1749
             +TH  I +L  +T YYF++QA+N  G GP+S  + F T
Sbjct: 1004 RLTH-QIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 59/290 (20%), Positives = 107/290 (36%), Gaps = 38/290 (13%)

Query: 219 IKKLASESVYVVSLQSMNSQG---RSQPVYRAALTKRKISEEDELDVP---DDISVRVMS 272
           +  L  E++Y   + + N  G    SQP+        K++ + EL VP   +++     S
Sbjct: 489 VGNLKPEAMYTFRVVAYNEWGPGESSQPI--------KVATQPELQVPGPVENLQAVSTS 540

Query: 273 SQSVLVSWVDPVLEK---QKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDT 329
             S+L++W  P       Q   +   + +    +  E+    YK        +E L   T
Sbjct: 541 PTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYK--------LEGLKKFT 592

Query: 330 VYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETE 389
            Y            G  +  +   T    P+  P+N+++  VN +   +  SW  LP   
Sbjct: 593 EYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRS--IKVSW--LPPPS 648

Query: 390 GKVKEYILSYAPALKPFGAKSL--TYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHS 447
           G    +I  Y    +    +    T   +    L  GL+ G +Y F++ A    G GP S
Sbjct: 649 GTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPS 708

Query: 448 KAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASP 497
             +    P       E + +++  P++P      P+        + P +P
Sbjct: 709 NWYTAETP-------ENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNP 751



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 32/112 (28%), Positives = 49/112 (43%), Gaps = 5/112 (4%)

Query: 1643 IIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDW--DKATPGDVVTGYLVYSASYEDF 1700
            I+P     S      APR++  V V     FV + W       G++ T  + +S   ++ 
Sbjct: 416  IVPKPAIPSSSVLPSAPRDVVPVLVSS--RFVRLSWRPPAEAKGNIQTFTVFFSREGDNR 473

Query: 1701 IRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESD 1752
             R   +TQ  S+  L + NLKP   Y F+V A N  G G  S  +   T+ +
Sbjct: 474  ERALNTTQPGSL-QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPE 524


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 196/894 (21%), Positives = 319/894 (35%), Gaps = 144/894 (16%)

Query: 519  APRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVA 578
            +P   Q + KK ++   +S   +   E           S+++ +KR  R P+        
Sbjct: 182  SPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPT-------- 233

Query: 579  PGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPAS 638
                      P   R+    K   S +T P P +  +  ++ A  AS+  TS   S  A+
Sbjct: 234  ----------PKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAA 283

Query: 639  LNDNDLVDSDEDERAVGSLHPKG--AFAQPRPALSPSRQSPSSVLRDRSSVHPGA----K 692
               +    +            +G   F++P    +    SP +  +  SS +       K
Sbjct: 284  AKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKK 343

Query: 693  PASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGG-------- 744
              S  R +P    +       AP   L+  HGGS + L T P    P++           
Sbjct: 344  EKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDR 403

Query: 745  ---KDGEDAPATNSNAPS-RSTMSSSVSSHLSSRTQVSEGAEA------------SDGES 788
               K  E  P ++S+  S  S   + VS H SS  +  + A A            S   S
Sbjct: 404  SPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRS 463

Query: 789  HGDGDRED----------GGRQAEATAQ--TLRARPASGHFHLLRHKPFAANGRSPSRFS 836
            HG   R+           G  ++ ATA+    R+R  +   H     P     RS  R+ 
Sbjct: 464  HGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWG 523

Query: 837  IGRGP-RLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVP 895
              R P R   S SPQ    SR+      ++    +  S   G      P           
Sbjct: 524  RSRSPQRRGRSRSPQRPGWSRSR-----NTQRRGRSRSARRGRSHSRSPA------TRGR 572

Query: 896  SSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQS 955
            S SR P  RG     R+P R  S  R  P     +S       + +  + A +    +  
Sbjct: 573  SRSRTPARRG-RSRSRTPARRRSRSR-TPTRRRSRSRTPARRGRSRSRTPARRRSRTRSP 630

Query: 956  TDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQH 1015
                +   SP  + G      S +R PA R +     P R   GR+  + P      S+ 
Sbjct: 631  VRRRSRSRSPARRSG-----RSRSRTPARRGRSRSRTPARR--GRSRSRTPARRSGRSRS 683

Query: 1016 H-PGPQSRDAGRSPSQPR---LSLTQAGRPR---PTSQGRSHSSSDPYTASSRGMLPTAL 1068
              P  + R   R+P + R    SL + GR     P  +GRS SSS+    S         
Sbjct: 684  RTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQ----- 738

Query: 1069 QNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQ 1128
                   + S  + S E++   + +    + +   + +  +     S +G+      +SQ
Sbjct: 739  -------RRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQ 791

Query: 1129 RGHAASPARPSRPGG--PQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAG 1186
                 +P R SR G   P++++R P R +   S PP K+   + S+QS S+     +   
Sbjct: 792  -----TPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK--- 843

Query: 1187 FFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKE--EREPAIALAPRGGSLAPVKRPL 1244
                    + S + P+  S ++P+  + +     +   E  P   L  R  S        
Sbjct: 844  --------VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSS 895

Query: 1245 PP------PPGSSPRASHVPSRLPPRSAATVSPVAGTH-----PWP-QYTTRAPPGHF-S 1291
            PP      PP  SP  S  P    P+  A +SP   +H     P P + T+R  P    S
Sbjct: 896  PPRVKSSTPPRQSPSRSSSPQ---PKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRS 952

Query: 1292 TTPMLSLRQRMM----HARFRNPLSRQPARPSYRQGYNGR----PNVEGKVLPG 1337
             +P  ++  R++    H+   +P ++       RQ ++G     P V+ +  PG
Sbjct: 953  VSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPG 1006



 Score = 91.7 bits (226), Expect = 6e-18
 Identities = 206/939 (21%), Positives = 334/939 (35%), Gaps = 130/939 (13%)

Query: 471  KPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKA 530
            K ++   ++P+P++  + +  S  ++     ++        K      A R P   + + 
Sbjct: 244  KRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRR 303

Query: 531  EELDLQSTE--ITGEEELGSREDS---PMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVR 585
             E D   +E   T  +   S E +   P SP + +D+ +  +  +R   S   P R++  
Sbjct: 304  GEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPS---PERSSTG 360

Query: 586  ARMPA-----LPRREGVDKPGFSLATQPRPGAP--PSASASPAHHASTQGTSHRPSLPAS 638
               PA       R  G  +P   LAT P    P  P + ASP    S   +  +  LP S
Sbjct: 361  PEPPAPTPLLAERHGGSPQP---LATTPLSQEPVNPPSEASPTRDRSPPKSPEK--LPQS 415

Query: 639  LNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSP-SRQSPSSVLRDRSSVHPGAKPASPA 697
             +      S +  +   S H   +   P+PA +P S +  SS    ++  H  AK     
Sbjct: 416  SSSESSPPSPQPTKV--SRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSH 473

Query: 698  RRTPHSGAAEEDSSASAPPSRL---SPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATN 754
              TP        S A+A   R    +P   G SR    Q   S    + G+         
Sbjct: 474  SHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGR 533

Query: 755  SNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDG----------GRQAEAT 804
            S +P R   S S ++    R++      A  G SH       G          GR    T
Sbjct: 534  SRSPQRPGWSRSRNTQRRGRSR-----SARRGRSHSRSPATRGRSRSRTPARRGRSRSRT 588

Query: 805  AQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQP-------SSSP-------Q 850
                R+R  +      R +  A  GRS SR    R  R +        S SP       +
Sbjct: 589  PARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSR 648

Query: 851  STVPSR---AHPRVPSHSD-SHPKLSSGIHGDEEDEKPLPATVVNDHVP----SSSRQPI 902
            S  P+R   +  R P+    S  +  +   G      P          P    S SR  +
Sbjct: 649  SRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLV 708

Query: 903  SRGWEDLRRSPQR----GASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDA 958
             RG     R+PQR    G+S  RK     + + + +++ P+ K S ++S+      S  +
Sbjct: 709  RRG-RSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRS 767

Query: 959  DTEGHSP--KAQPGSTDRHASPARPPAARSQQHPSVPR---RMTPGRAPQQQPPPPVATS 1013
              +      ++  GS+      ++ P  RS+   S P+   R  P R+     PPP   S
Sbjct: 768  KAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKS 827

Query: 1014 -----QHH----PGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRS--HSSSDPYTASSR- 1061
                 Q H    P P+ + +G  P Q  ++  QA     T Q RS   SS DP   S   
Sbjct: 828  KTPSRQSHSSSSPHPKVK-SGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTP 886

Query: 1062 ------GMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAAS--------L 1107
                  G  P  +++     Q      S + + + + +P   + +  ++ S         
Sbjct: 887  SRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTT 946

Query: 1108 PKHQQVESPTG----------AGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPG 1157
            P+  +  SP            + +G      +    +P R S  G      +V ++  PG
Sbjct: 947  PRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPG 1006

Query: 1158 KSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADG 1217
             S   SK P      Q  S +   +   G          S S+     SSTP G      
Sbjct: 1007 PSLSGSKSPCP----QEKSKDSLVQSCPG----------SLSLCAGVKSSTPPGESYFGV 1052

Query: 1218 SLAKEEREPAIALAPRGGSLAP-VKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTH 1276
            S  + + +   +   R  + +P V++     P    ++   P     RS++ V+ +A   
Sbjct: 1053 SSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRS 1112

Query: 1277 PWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQP 1315
            P      R   G FS +PML        +RF++  S  P
Sbjct: 1113 P-----IRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYP 1146



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 178/838 (21%), Positives = 289/838 (34%), Gaps = 77/838 (9%)

Query: 455  PTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKIL 514
            P+  +++ + + E    P+ P P S SP +P  +     P   + R+  +  +D K    
Sbjct: 1473 PSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQ--RERSGSESSVDQKTV-- 1528

Query: 515  ANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGH 574
                 P   + R+  ++ELD++ +    E     R +S  SP      +  LR  SR G 
Sbjct: 1529 --ARTPLGQRSRSGSSQELDVKPSASPQE-----RSESDSSPDSKAKTRTPLRQRSRSGS 1581

Query: 575  SVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPS 634
            S     ++ +       PRR    + G S   + +P A P A        S   +S  P 
Sbjct: 1582 SPEVDSKSRLS------PRRS---RSGSSPEVKDKPRAAPRAQ-------SGSDSSPEPK 1625

Query: 635  LPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPA 694
             PA         S    +  G      +  +  P   P  +S ++    RSS  P  K  
Sbjct: 1626 APAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPP--KSRTARRGSRSSPEPKTKSR 1683

Query: 695  SPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATN 754
            +P RR     + E    A       S      +R      H  SP     +  E + ++ 
Sbjct: 1684 TPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSR 1743

Query: 755  SNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQ-TLRARPA 813
                + S  + + S    S +    G + S   S  +  R    R    ++Q T R R  
Sbjct: 1744 RRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQR 1803

Query: 814  SGHFHLLRHKPFAANG---RSPSR----FSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSD 866
            S     +  +    +G   RSP+R     +  R  R +  + P S   SR+         
Sbjct: 1804 SRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKR 1863

Query: 867  SHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIP 926
            S  + S   H       PL    ++     S   P+SR     R S  R  S  R  P+ 
Sbjct: 1864 SRSRASPATHRRSRSRTPL----ISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPV- 1918

Query: 927  ENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARS 986
             + + + + T P  +  S         +S    T   S    P  T R +    PP  R 
Sbjct: 1919 -SRRRSRSRTPPVTRRRS---------RSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRR 1968

Query: 987  QQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQ 1046
            +   S    +T  R+  +  P     S+    P +R   RS + P        R  P  +
Sbjct: 1969 RSR-SRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIR 2027

Query: 1047 GRSHSSSDPYTAS-SRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAA 1105
             RS S +       SR   P A++ +      S    +   +    R+P    R   + +
Sbjct: 2028 RRSRSRTPLLPRKRSRSRSPLAIRRRSR----SRTPRTARGKRSLTRSPPAIRRRSASGS 2083

Query: 1106 SLPKHQQVESPTGAGAGGDHRS----QRGHAASPARPSRPGGPQSRARVPSRAAPGKSEP 1161
            S  + +    P      G             +  +RPS    P  R R     +PG  EP
Sbjct: 2084 SSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCR-----SPGMLEP 2138

Query: 1162 --PSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSL 1219
               S+ P+S   Q   S  D              D   +SVP+  + S       A  SL
Sbjct: 2139 LGSSRTPMSVLQQAGGSMMDGPGPRI-------PDHQRTSVPENHAQSRIALALTAI-SL 2190

Query: 1220 AKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHP 1277
                  P+++ A     ++ V  P+P     +  A+++ SR+P  SAA ++  +   P
Sbjct: 2191 GTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTP 2248



 Score = 82.4 bits (202), Expect = 4e-15
 Identities = 191/896 (21%), Positives = 314/896 (35%), Gaps = 115/896 (12%)

Query: 483  RAPASSQHPSVPASPQGR--NAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEI 540
            ++  S  H S  +SP+ R  +++   L  K++    GG  R      + A    ++    
Sbjct: 1060 QSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDR- 1118

Query: 541  TGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGR--TAVRARMPALPRREGV- 597
             GE        S MSP  ++ Q  +   P+   +S++   R  TA      ALP +E   
Sbjct: 1119 -GEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDAT 1177

Query: 598  ----------------DKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLND 641
                            D+P  SL  +     PP   +       T+      +LP S  D
Sbjct: 1178 ASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETK--EQNSALPTSSQD 1235

Query: 642  NDLVDS-DEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRT 700
             +L++  ++ E   G +      +     +S S    S  + +R +V   +     ++  
Sbjct: 1236 EELMEVVEKSEEPAGQI--LSHLSSELKEMSTSNFESSPEVEERPAV---SLTLDQSQSQ 1290

Query: 701  PHSGAAEEDSSASA-PPSRLSPPHGGSSRLLPTQPHLSSPLS--KGGKDGEDAPATNSNA 757
                A E  S AS+      SP H   S     +    SPL     G  G     T  N 
Sbjct: 1291 ASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLG-----TEMNT 1345

Query: 758  PSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHF 817
               S +   ++    ++ +     +  +  +     R  G   +E +   +     S + 
Sbjct: 1346 GFSSEVKEDLNGPFLNQLETDPSLDMKEQST-----RSSGHSSSELSPDAVEKAGMSSNQ 1400

Query: 818  HLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSH---SDSHPKLSSG 874
             +           SP   ++ R P  + SSS  S       PR PS    S S P L  G
Sbjct: 1401 SI----------SSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDG 1450

Query: 875  IHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEP----IPENPK 930
                        +   + H  S S    S G +D+ R+P RG S     P    +P+ P+
Sbjct: 1451 ------------SGTPSRHSLSGS----SPGMKDIPRTPSRGRSECDSSPEPKALPQTPR 1494

Query: 931  STG-ADTHPQGKYSSLASKAQ--DVQQSTDADTEGHSPKAQPG----STDRHASPARPPA 983
                + + P+     L  + +    + S D  T   +P  Q      S +    P+  P 
Sbjct: 1495 PRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQ 1554

Query: 984  ARSQQHPSVPRRM---TPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGR 1040
             RS+   S   +    TP R   +    P   S+    P+   +G SP      +    R
Sbjct: 1555 ERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPE-----VKDKPR 1609

Query: 1041 PRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAP-AHAAR 1099
              P +Q  S SS +P   + R +   +        +G   + S+  E+     P +  AR
Sbjct: 1610 AAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTAR 1669

Query: 1100 AKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSR--AAPG 1157
                ++  PK +    P    +       R    S    S    P++R+R P R   +P 
Sbjct: 1670 RGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPS 1729

Query: 1158 KSEP-PSKRPLSSKSQQSVSAEDDEEEDA-GFFKGGKEDLL--SSSVPKWPSSSTPRGGK 1213
             S P P+++  SS+ ++S S+   +     G     K   L  S S  +   + T R  +
Sbjct: 1730 VSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRR-R 1788

Query: 1214 DADGSLAKEERE-------PAIALAPRGGSLAPVKRPLPPPPG-SSPRASHVPSRLPPRS 1265
            D  GS     R          +    RGGS    + P       +S R     SR PP S
Sbjct: 1789 DRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTS 1848

Query: 1266 AATVSPVAGTHPWPQYTTRAPPGHF----STTPMLSLRQRMMHARFRNPLSRQPAR 1317
                       PW +  +RA P       S TP++S R+        +P+SR+ +R
Sbjct: 1849 RKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRT---SPVSRRRSR 1901



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 144/638 (22%), Positives = 236/638 (36%), Gaps = 106/638 (16%)

Query: 565  TLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHA 624
            T RPP     + +A   + V A +P +  R     P  +LA++      P+ASA+  + A
Sbjct: 2192 TARPPPSMSAAGLAARMSQVPAPVPLMSLRTA---PAANLASRI-----PAASAAAMNLA 2243

Query: 625  STQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDR 684
            S +     P++P ++N   L DS     A          A PR A++PS  + +     R
Sbjct: 2244 SAR----TPAIPTAVN---LADSRTPAAAAAM-----NLASPRTAVAPSAVNLAD---PR 2288

Query: 685  SSVHP-----GAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLL-PTQPHLSS 738
            +   P     GA+  +       +G+    ++A+ P S  +P    S+ L+ P   H ++
Sbjct: 2289 TPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATA 2348

Query: 739  PLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGG 798
            P++  G     A A  S   +R   + S ++  S R  +S     S   S    DR    
Sbjct: 2349 PVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDR---- 2404

Query: 799  RQAEATAQTLRARPASGHFHLLRH-KPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRA 857
                A ++T  + P+       R   P +  G++PS+  +   P  Q    P+S VPS  
Sbjct: 2405 ----ARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLL---PPAQ--DQPRSPVPS-- 2453

Query: 858  HPRVPSHSDSHPKL---SSGIHGDEEDEKPLPATVVN---DH-----VPSSSRQPISRGW 906
                 + SD    L   ++ + G +       AT  +   DH     VP+        G 
Sbjct: 2454 -----AFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGE 2508

Query: 907  EDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQ-STDADTEGHSP 965
                   Q+ ++L   +P  E   S+ + +      SS +S +      S+ +D+EG S 
Sbjct: 2509 PPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSL 2568

Query: 966  KAQPG-STDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDA 1024
              QP  +  R  SP           P+    +  GR P+  P      S       S  +
Sbjct: 2569 PVQPEVALKRVPSPT----------PAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSS 2618

Query: 1025 GRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDST 1084
              S S    S + +     +S   S SSS P  A      P AL       +        
Sbjct: 2619 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPG---PQALPKPASPKK----PPPG 2671

Query: 1085 EVEAQDVRAPAHAARAKEAAASLPKHQQVESP--------TGAGAGGDHRSQRGHAASPA 1136
            E  ++  R P  + R   + +  P  ++  SP        + +   G  R QRG + SP+
Sbjct: 2672 ERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPS 2731

Query: 1137 RPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQS 1174
               R                   E PS RP+  +S +S
Sbjct: 2732 HKRR------------------RETPSPRPMRHRSSRS 2751



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 136/579 (23%), Positives = 201/579 (34%), Gaps = 115/579 (19%)

Query: 567  RPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPS----ASASPAH 622
            R P+      +A  RTAV      L        P  +LA    P A  +     S +P  
Sbjct: 2260 RTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPT 2319

Query: 623  HASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQS----PS 678
             A+   +S  P  PAS N             VG   P+ A A     ++ SR +    P+
Sbjct: 2320 AANYPSSSRTPQAPASAN------------LVG---PRSAHATAPVNIAGSRTAAALAPA 2364

Query: 679  SVLRDRSS-VHPGAKPASPARRTPHSGAAEEDSSASAPP------SRLSPPHGGSSRLLP 731
            S+   R +    GA   SP  R P S A E  S  ++PP      SR  P     SR+  
Sbjct: 2365 SLTSARMAPALSGANLTSP--RVPLS-AYERVSGRTSPPLLDRARSRTPPSAPSQSRM-- 2419

Query: 732  TQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQ--------------V 777
            T     SP S+ G+    AP+ +   P++    S V S  S +++              +
Sbjct: 2420 TSERAPSPSSRMGQ----APSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSL 2475

Query: 778  SEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSI 837
            S GA A+   S GD +              + + PA G  H    +P A+ G        
Sbjct: 2476 SSGAVATTTSSAGDHNG-------------MLSVPAPGVPHSDVGEPPASTGAQQPSALA 2522

Query: 838  GRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSS 897
               P  +  SS  S+  S +     S S S     S     E    P+   V    VPS 
Sbjct: 2523 ALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSP 2582

Query: 898  SRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTD 957
            +  P     E   R P         EP P   K   + +      SS +S +     S+ 
Sbjct: 2583 TPAPKEAVREG--RPP---------EPTPAKRKRRSSSSSSSSSSSSSSSSSSS-SSSSS 2630

Query: 958  ADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHP 1017
            + +   S  +   S+    SPA+P   ++   P+ P++  PG    + P  P+ + +   
Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAKP-GPQALPKPASPKKPPPGERRSRSPRKPIDSLR--- 2686

Query: 1018 GPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQG 1077
               SR    SP + R    Q   P P  Q     SS     S RG               
Sbjct: 2687 --DSRSLSYSPVERRRPSPQ---PSPRDQ----QSSSSERGSRRG--------------- 2722

Query: 1078 SYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESP 1116
                     +  D R+P+H  R +  +    +H+   SP
Sbjct: 2723 ---------QRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 240/1144 (20%), Positives = 361/1144 (31%), Gaps = 223/1144 (19%)

Query: 549  REDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKP------GF 602
            R     SP+    + R+ R P+R G S         R+R     RR G  +       G 
Sbjct: 633  RRSRSRSPARRSGRSRS-RTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGR 691

Query: 603  SLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGA 662
            S +  PR G   S S      + ++ T  R     S ++          R+  +  P+  
Sbjct: 692  SRSRTPRRGRSRSRSLVRRGRSHSR-TPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMK 750

Query: 663  FAQPRPALSPSRQSPSSVLRDRSSVH---------PGAKPASPARRTPHSGAAEEDSSAS 713
             ++     S S  SP S  + R S+          P  K  +P RR+  SG+++  + + 
Sbjct: 751  KSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS-RSGSSQPKAKSR 809

Query: 714  APPSRL----SPPHGGSSRLLPTQPHLSS---PLSKGGKDGEDAPATNSNAPS------- 759
             PP R     SPP    S+    Q H SS   P  K G        T+  A         
Sbjct: 810  TPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQR 869

Query: 760  RSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHL 819
            RS   SS    L SRT       +  G S          RQ+ + + + + +        
Sbjct: 870  RSCFESSPDPELKSRTP---SRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPK-VKAIISP 925

Query: 820  LRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDE 879
             +     ++  SPSR +    PR   S SP S V SR  PR      S P          
Sbjct: 926  RQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSP---------- 975

Query: 880  EDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLH-RKEPIPENPKSTG----- 933
             D K  P T      P  S       +  ++     G SL   K P P+           
Sbjct: 976  -DTKVKPETP-----PRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSC 1029

Query: 934  -----------ADTHPQGKY---SSLASKAQDVQQSTDADTEGHSPKAQP---------- 969
                       + T P   Y   SSL  K Q  Q S D  ++  SP+ +           
Sbjct: 1030 PGSLSLCAGVKSSTPPGESYFGVSSLQLKGQS-QTSPDHRSDTSSPEVRQSHSESPSLQS 1088

Query: 970  -------GSTDRHASP-----ARPPAARSQQHPSVPRRMTPGRAPQQQ------PPPPVA 1011
                   G   R +SP     +R P  + +   S    +  G +P+Q          P  
Sbjct: 1089 KSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTV 1148

Query: 1012 TSQHHPG---------------PQSRDAGRSP-------------SQPRLSLTQAGRPRP 1043
             S    G               P   DA  SP              +P  SL      R 
Sbjct: 1149 DSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRT 1208

Query: 1044 TSQGRSHSSSDPYTASSRGMLPTALQNQD--------EDAQG-------------SYDDD 1082
              + RS + S P T      LPT+ Q+++        E+  G             S  + 
Sbjct: 1209 PPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNF 1268

Query: 1083 STEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGA-GGDHRSQRGHAASPA----- 1136
             +  E ++  A +      ++ ASL   + VE P+ A + GG H S      S +     
Sbjct: 1269 ESSPEVEERPAVSLTLDQSQSQASL---EAVEVPSMASSWGGPHFSPEHKELSNSPLREN 1325

Query: 1137 --------RPSRPGGPQSRARVPSRAAPGKSEP--------PS----KRPLSSKSQQSVS 1176
                    R S P G +      S      + P        PS    ++   S    S  
Sbjct: 1326 SFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSE 1385

Query: 1177 AEDDEEEDAGFFKGGK-EDLLSSSVPKWPS---SSTPRGGKDADGSLAKEEREPAIALAP 1232
               D  E AG          +  +VP+ PS   SS+    +  DG      R      +P
Sbjct: 1386 LSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSP 1445

Query: 1233 --RGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHF 1290
              R GS  P +  L    GSSP    +P R P R  +           PQ  T  P    
Sbjct: 1446 GLRDGSGTPSRHSL---SGSSPGMKDIP-RTPSRGRSECDSSPEPKALPQ--TPRPRSRS 1499

Query: 1291 STTPMLSLR----QRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQR 1346
             ++P L+ +    QR       +   +  AR    Q      + E  V P ++ +   + 
Sbjct: 1500 PSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSES 1559

Query: 1347 IINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGL 1406
              +     K    L +     +       S  +P R +  G    + D        P   
Sbjct: 1560 DSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR-SGSSPEVKD-------KPRAA 1611

Query: 1407 PLFGQGRHGTPLANAQDKPIL-----------SLGGKPLVGLEVIKKTTHPP-------- 1447
            P    G   +P   A     L             G  P           HPP        
Sbjct: 1612 PRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRG 1671

Query: 1448 -TTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPT 1506
              ++ +P T +   P   + R +   TR+   +RR+ +   +   R+ T      +P+ +
Sbjct: 1672 SRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVS 1731

Query: 1507 TPIP 1510
            +P P
Sbjct: 1732 SPEP 1735



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 110/485 (22%), Positives = 157/485 (32%), Gaps = 91/485 (18%)

Query: 478  SSPSPRAPAS-------SQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKA 530
            SS +P+APAS       S H + P +  G              LA           A   
Sbjct: 2326 SSRTPQAPASANLVGPRSAHATAPVNIAGSRTA--------AALAPASLTSARMAPALSG 2377

Query: 531  EELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPA 590
              L      ++  E +  R   P+      D+ R+  PPS       AP ++ + +    
Sbjct: 2378 ANLTSPRVPLSAYERVSGRTSPPLL-----DRARSRTPPS-------APSQSRMTSERAP 2425

Query: 591  LPRREGVDKPGFSLA--TQPRPGAP-PSASASPAHHASTQGTSHRPSLPASLNDNDLVDS 647
             P       P  SL    Q +P +P PSA +  +     Q T    S   S        S
Sbjct: 2426 SPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTS 2485

Query: 648  DEDERAVGSLHPKGAFAQPRPALSPSR--QSPSSVLRDRSSVHPGAKPASPARRTPHSGA 705
               +         G  + P P +  S   + P+S    + S     +PA   R +  S +
Sbjct: 2486 SAGDH-------NGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSS 2538

Query: 706  AEEDSSASAPPSRLSPPHGGSSR-----LLPTQPHLS-------SPLSKG----GKDGED 749
            +   SS+S+  S  S   G SS       LP QP ++       +P  K     G+  E 
Sbjct: 2539 SSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEP 2598

Query: 750  APATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLR 809
             PA      S S+ SSS SS  SS +  S  + +S   S            + A      
Sbjct: 2599 TPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPA------ 2652

Query: 810  ARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPS-SSPQSTVPSRAHPRVPSHS-DS 867
                         KP               GP+  P  +SP+   P     R P    DS
Sbjct: 2653 -------------KP---------------GPQALPKPASPKKPPPGERRSRSPRKPIDS 2684

Query: 868  HPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPE 927
                 S  +   E  +P P     D   SSS +   RG     RSP          P P 
Sbjct: 2685 LRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPM 2744

Query: 928  NPKST 932
              +S+
Sbjct: 2745 RHRSS 2749


>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
           [Homo sapiens]
          Length = 1250

 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 106/422 (25%), Positives = 174/422 (41%), Gaps = 56/422 (13%)

Query: 55  LKVTWDP-PKDATSRPVEHYNIAYGKSLKSLKY-IKVNAETYSFLIEDVEPGVVYFVLLT 112
           ++V W P P   ++  V  Y I YG   +   +  +V       ++  ++P  VY V ++
Sbjct: 543 IRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRIS 602

Query: 113 AENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDR 172
           A   +G   P          +W+       + P   N++     VP  P  ++V++  + 
Sbjct: 603 AGTAAGFGAP---------SQWMHH-----RTPSMHNQS----HVPFAPAELKVQAKMES 644

Query: 173 LSVAWKAP----RLSGAK-------SPRRSRGFLL--GYGESGRKMNYVPLTRDERTHEI 219
           L V+W+ P    ++SG K       +   + G  L  G G+    +  V L +  + +E+
Sbjct: 645 LVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYEL 704

Query: 220 KKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDD---------ISVRV 270
            +L    +Y V L + N          AA+ K K  +    D+P           +    
Sbjct: 705 TQLVPGRLYEVKLVAFNKHEDGY----AAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAES 760

Query: 271 MSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKG--ELARWDYKQIANRRVLIENLIPD 328
            SS S+ + W  P     K V     YTVR+   G    +   Y   +   +LI  L P 
Sbjct: 761 NSSTSIWLRWKKPDFTTVKIV----NYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPF 816

Query: 329 TVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPET 388
           T YEFAV+    + DG + + V + T    P+T P +L + P+   P+ V   W    E 
Sbjct: 817 TKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLT--PSTVRLHWCPPTEP 874

Query: 389 EGKVKEYILSYAP--ALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPH 446
            G++ EY++ Y+            LT  G+  SA V GL+   RY FK+ A    G GP 
Sbjct: 875 NGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPF 934

Query: 447 SK 448
           S+
Sbjct: 935 SR 936



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 50/207 (24%), Positives = 93/207 (44%), Gaps = 13/207 (6%)

Query: 247 AALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGE 306
           AA +   +  E     P  ++   +SS +VLV+W  P +  ++ +     +++ Y++   
Sbjct: 416 AAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQII----GFSLHYQKARG 471

Query: 307 LARWDYKQIANR---RVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAP 363
           +   +Y+   N     + + +L P+T YEF V         + ST     T +  P+ AP
Sbjct: 472 MDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAP 531

Query: 364 ENLNVWPVNGKPTVVAASWDALPE--TEGKVKEYILSYAPALKPFGAKSLTYPGDTTSAL 421
           + L++   N  P+ +  +W  LP   + G+V +Y + Y    K     S    G+ T  +
Sbjct: 532 Q-LSLSSPN--PSDIRVAWLPLPPSLSNGQVVKYKIEYGLG-KEDQIFSTEVRGNETQLM 587

Query: 422 VDGLQPGERYLFKIRATNRRGLGPHSK 448
           ++ LQP + Y  +I A    G G  S+
Sbjct: 588 LNSLQPNKVYRVRISAGTAAGFGAPSQ 614



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 28/108 (25%), Positives = 46/108 (42%), Gaps = 19/108 (17%)

Query: 1645 PNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKAT-PGDVVTGYLVYSASYEDFIRN 1703
            P+DL+ S L P                S V + W   T P   +  YL+  +S      +
Sbjct: 851  PSDLRLSPLTP----------------STVRLHWCPPTEPNGEIVEYLILYSSNHTQPEH 894

Query: 1704 KWS--TQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVT 1749
            +W+  T   ++    +  L+ +TRY+FK+ A+   G GP S     +T
Sbjct: 895  QWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVIT 942


>gi|83281200 protogenin [Homo sapiens]
          Length = 1150

 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 106/451 (23%), Positives = 185/451 (41%), Gaps = 51/451 (11%)

Query: 38  DHPLKPRHVKLLS-TKMGLKVTWDP-PKDATSRPVEHYNIAYGKSLK-SLKYIKVNAETY 94
           D PL+P  + L S +   + ++W P P       V  Y +++  S + S++ +++   T+
Sbjct: 515 DVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTH 574

Query: 95  SFLIEDVEPGVVYFVLLTAENHSGVSRP-VYRAESPPGGEWIEIDGFPIKGPGPFNETVT 153
            +L+E ++P  VY V +TA    G+    V+ +   P    ++    P     P N T  
Sbjct: 575 EYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTT- 633

Query: 154 EKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNY-VPLTR 212
                              +SV W+       +     +G+ L Y E G++ N  + L  
Sbjct: 634 -------------------ISVRWQ----QDVEDTAAIQGYKLYYKEEGQQENGPIFLDT 670

Query: 213 DERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDEL----DVPDDISV 268
            +  + +  L     Y V L + N+        +   T   +S  D +      P  +  
Sbjct: 671 KDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYA 730

Query: 269 RVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKG--ELARWDYKQIANRRVLIENLI 326
           +  +S S+ + W  P     + +     YT+R    G    +   Y Q +   +L++ L 
Sbjct: 731 KANTSSSIFLHWRRPAFTAAQII----NYTIRCNPVGLQNASLVLYLQTSETHMLVQGLE 786

Query: 327 PDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALP 386
           P+T YEFAVR+   +    WS  V+  T   AP   P  + V  +     +V  SW    
Sbjct: 787 PNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALV--SWKPPD 844

Query: 387 ETEGKVKEYILSYAPALKPFGA---KSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGL 443
             E  V  Y + YA + K + A   + L   G  T AL++ L  G  Y+ KI A+N  G 
Sbjct: 845 GPETVVTRYTILYA-SRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGE 903

Query: 444 GPHSKAFIVAMPTTSKADVEQNTEDNGKPEK 474
           GP S +  +A+        ++ +E N +P++
Sbjct: 904 GPFSNSVELAVLP------KETSESNQRPKR 928



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 65/234 (27%), Positives = 103/234 (44%), Gaps = 17/234 (7%)

Query: 219 IKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLV 278
           I ++  E   +    + NSQG    + RA LT   +  ED    P ++    MSS ++L+
Sbjct: 382 INQIIPEDDAIYQCMAENSQGSI--LSRARLTV--VMSEDRPSAPYNVHAETMSSSAILL 437

Query: 279 SWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANR---RVLIENLIPDTVYEFAV 335
           +W  P+    K +     Y+V Y +   L   +Y+ +        +I++L P + Y F +
Sbjct: 438 AWERPLYNSDKVIA----YSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYI 493

Query: 336 RISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPE--TEGKVK 393
                    + S  V Q T E  P   PE   +   +  PT +  SW  +P     G+V 
Sbjct: 494 VAYMPMGASQMSDHVTQNTLEDVPLRPPE---ISLTSRSPTDILISWLPIPAKYRRGQVV 550

Query: 394 EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHS 447
            Y LS+  + +    + L  PG T   L++GL+P   YL +I A  R GLG  S
Sbjct: 551 LYRLSFRLSTEN-SIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESS 603



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 7/100 (7%)

Query: 1651 SDLP--PQHAPRNITVVAVEGCHSFVIVDWDKAT-PGDVVTGYLVYSASYEDFIRNKWST 1707
            S LP  P   P  + V  +E      +V W     P  VVT Y +  AS + +I  +W  
Sbjct: 813  STLPEAPAGPPVGVKVTLIED--DTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQV 870

Query: 1708 --QASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSV 1745
              +  ++T   +ENL     Y  K+ A N  G GP S SV
Sbjct: 871  LHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSV 910



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 7/106 (6%)

Query: 1658 APRNITVVAVEGCHSFVIVDWDKAT-PGDVVTGYLVYSASYEDFIRNKWSTQ-ASSVTHL 1715
            AP N+    +    S +++ W++     D V  Y V+    E     ++     +  TH 
Sbjct: 421  APYNVHAETMSS--SAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHY 478

Query: 1716 PIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPP 1761
             I++L+P + Y F + A  P G   +S  V+  T  D PL   RPP
Sbjct: 479  IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPL---RPP 521



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 3/54 (5%)

Query: 1710 SSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGG 1763
            +S TH+ ++ L+PNT+Y F V+        P SP V   T  + P     PP G
Sbjct: 775  TSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAP---AGPPVG 825


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 185/922 (20%), Positives = 312/922 (33%), Gaps = 117/922 (12%)

Query: 703  SGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSP---LSKGGKDGEDAPATNSNAPS 759
            S  AE  +  S P S+ +PP  G+S+ + +    S       K  K  E    T  ++ S
Sbjct: 61   SFCAEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVS 120

Query: 760  RSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHL 819
             +  SSS SS  SS + + +   + +  ++ +  ++   +  +      +  P       
Sbjct: 121  ENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTP------- 173

Query: 820  LRHKP----FAANGRSPSRFSI-----GRGPRLQPSSSPQSTV--PSRAHPRVPSHSDSH 868
               KP     A +G     F +           + S+SP+ T   P    P +P +SD+ 
Sbjct: 174  ---KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 230

Query: 869  PKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPEN 928
             + S  ++ +         TV      ++++Q  + G E       +  S    + I   
Sbjct: 231  KETSLTVNKE--------TTVETKETTTTNKQTSTDGKE-------KTTSAKETQSIE-- 273

Query: 929  PKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQ 988
             K++  D  P  K  +  +   +      A T    P           +P  P     + 
Sbjct: 274  -KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKS 332

Query: 989  HPSVPRRMTPG--RAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQ 1046
             P+ P+   P   ++    P  P  T+   P P +      P +P  + T+   P  T  
Sbjct: 333  APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT------PKEPAPTTTKEPAPTTTKS 386

Query: 1047 GRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAAS 1106
              + +  +P   + +   PT  +             + +  A   + PA     KE A +
Sbjct: 387  APT-TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT-PKEPAPT 444

Query: 1107 LPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRP 1166
             PK     +P          + +  A +  +   P  P+  A   +++AP  ++ P+  P
Sbjct: 445  APKKPAPTTPKEPAP----TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPA--P 498

Query: 1167 LSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEE--- 1223
             ++KS  +   E             KE   + + PK P+ +TP   K    +  KE    
Sbjct: 499  TTTKSAPTTPKEPSPTTT-------KEP--APTTPKEPAPTTP---KKPAPTTPKEPAPT 546

Query: 1224 --REPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWP-- 1279
              +EPA     +     P K P P  P  +  A   P +L P +   ++P     P P  
Sbjct: 547  TPKEPAPTTTKKPAPTTP-KEPAPTTPKET--APTTPKKLTPTTPEKLAPTTPEKPAPTT 603

Query: 1280 ----------QYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPN 1329
                      + T   P     TTP  +          + P    P  P+        P 
Sbjct: 604  PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP-----KEPAPTTPKEPAPTTPKEPAPT 658

Query: 1330 VEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDG 1389
               +  P +  K      +  P  T       + L           +   P      G  
Sbjct: 659  TPKETAP-TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 717

Query: 1390 RTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTT 1449
             T    E  P    +  P   +G   T L             K L            PTT
Sbjct: 718  PT-TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-----------PTT 765

Query: 1450 TMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPI 1509
            T  PT+TT+  P  TTP+ T  TT +      TT ++P  T   T   TT+   TPTT  
Sbjct: 766  TKGPTSTTSDKPAPTTPKETAPTTPKEPAP--TTPKKPAPTTPETPPPTTSEVSTPTT-- 821

Query: 1510 PTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGL-ETDTAVPTEEAYVIYDEDYEFE 1568
             T  P T+ +  D+    +S+   P+      +  G+  T T   T+       +D   +
Sbjct: 822  -TKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD---K 877

Query: 1569 TSRPPTTTEPSTTATTPRVIPE 1590
            T+     T P TT   P++  E
Sbjct: 878  TTERDLRTTPETTTAAPKMTKE 899



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 191/986 (19%), Positives = 319/986 (32%), Gaps = 160/986 (16%)

Query: 610  PGAPPSASASPAHHASTQG----TSHRPSLPASLNDNDLVDSDE--DERAVGSLHPKGAF 663
            P +PPS+  +P    ++Q     T   P  P       +++S+E  +E +V       + 
Sbjct: 69   PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 128

Query: 664  AQPRPALSPSRQSPSSV-------LRDRSSVHPGAKPASPARRTPHSGAAEEDSSAS--- 713
            +    + S  R+  SS        L+ +  V    K  +  + TP     +E  S     
Sbjct: 129  SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 188

Query: 714  ----APPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSS 769
                  P   +  H   S         +SP     K     P+   N+ +    S +V+ 
Sbjct: 189  DFKVTTPDTSTTQHNKVS---------TSPKITTAKPINPRPSLPPNSDTSKETSLTVNK 239

Query: 770  HLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANG 829
              +  T+ +     ++ ++  DG  +    +   + +   A+  +    +L  KP     
Sbjct: 240  ETTVETKETT---TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA-KP----- 290

Query: 830  RSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATV 889
             +P   +  +GP L     P  T P       P                   ++P P T+
Sbjct: 291  -TPKAETTTKGPALTTPKEPTPTTPKEPASTTP-------------------KEPTPTTI 330

Query: 890  VNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKA 949
             +   P++ ++P     +    +P+  A    KEP P  PK     T  +   ++  S  
Sbjct: 331  KS--APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP 388

Query: 950  QDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPP 1009
                 +T  +    +PK    +T +  +P  P     +  P+ P+      AP  + P P
Sbjct: 389  -----TTPKEPAPTTPKKPAPTTPKEPAPTTP----KEPTPTTPKEP----APTTKEPAP 435

Query: 1010 VATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQ 1069
                +  P    + A  +P +P  +  +   P  T +    +  +P   +++   PT  +
Sbjct: 436  TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA-PTTTK 494

Query: 1070 NQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQ-----QVESPTGAGAGGD 1124
                    S      E      + PA     KE A + PK       +  +PT       
Sbjct: 495  EPAPTTTKSAPTTPKEPSPTTTKEPAPTT-PKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 553

Query: 1125 HRSQRGHAASPARPSRPGGPQSRARVPSR-----------AAPGKSEPPSKRPLSSKSQQ 1173
              +++    +P  P+     ++    P +             P K  P +   L+  + +
Sbjct: 554  TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 613

Query: 1174 SVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKE----------- 1222
              +    EE      K    +      P  P    P   K+   +  KE           
Sbjct: 614  EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 673

Query: 1223 ----EREPAIALAPRGGSLAPVK----------RPLPPPP-GSSPRASHVPSRLPPRSAA 1267
                E  P     P    LAP            +P P  P G++P     P+   P+  A
Sbjct: 674  TTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPA 733

Query: 1268 TVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGR 1327
              +P  GT P    TT   P    TTP     + +     + P S    +P+        
Sbjct: 734  PTTP-KGTAP----TTLKEPA--PTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETA 786

Query: 1328 PNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGG 1387
            P    +  P +  KP        P  T  V                  +   P  I    
Sbjct: 787  PTTPKEPAPTTPKKPAPTTPETPPPTTSEVST--------------PTTTKEPTTIHKSP 832

Query: 1388 DGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPP 1447
            D       E TP +S +  P   +     P       P  +   KP +      KTT   
Sbjct: 833  D-------ESTPELSAEPTPKALENSPKEPGVPTTKTPAAT---KPEMTTTAKDKTTERD 882

Query: 1448 TTTMQPTTTTTPLPT---------TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTT--- 1495
              T   TTT  P  T         TT  + T  TT+ T+TT + TT    TT++TTT   
Sbjct: 883  LRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAP 942

Query: 1496 RTTTTTTPTPTTPIPTCPPGTLERHD 1521
            + TTT     TT I   P  T +  D
Sbjct: 943  KVTTTKKTITTTEIMNKPEETAKPKD 968



 Score = 82.4 bits (202), Expect = 4e-15
 Identities = 213/1147 (18%), Positives = 352/1147 (30%), Gaps = 202/1147 (17%)

Query: 435  IRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVP 494
            I++T +R   P +K       T    + E+ TE++   E  E SS S  + +SS    + 
Sbjct: 88   IKSTTKRSPKPPNKK-----KTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIK 142

Query: 495  ASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPM 554
            +S      ++L   LK K        +KP  +    +E                      
Sbjct: 143  SSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAG-------------------- 182

Query: 555  SPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRAR----MPALPRREGVDKPGFSLATQPRP 610
            S  D  D K T    S   H+ V+       A+     P+LP      K   SL      
Sbjct: 183  SGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET-SLTVNKET 241

Query: 611  GAPPSASASPAHHASTQGTSHRPSLPA--SLNDNDLVDSDEDERAVGSLHPKGAFAQPRP 668
                  + +     ST G     S     S+      D     + +    PK       P
Sbjct: 242  TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 301

Query: 669  ALS-PSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSS 727
            AL+ P   +P++             P  PA  TP         SA   P   +P    ++
Sbjct: 302  ALTTPKEPTPTT-------------PKEPASTTPKEPTPTTIKSAPTTPKEPAPT---TT 345

Query: 728  RLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGE 787
            +  PT P   +P +      E AP T       +T   + ++  S+ T   E A  +  +
Sbjct: 346  KSAPTTPKEPAPTTTK----EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKK 401

Query: 788  SHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSS 847
                  +E      +    T    PA         +P     + P+  +  + P      
Sbjct: 402  PAPTTPKEPAPTTPKEPTPTTPKEPAP-----TTKEPAPTTPKEPAP-TAPKKPAPTTPK 455

Query: 848  SPQSTVPSRAHPRVPSH-SDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGW 906
             P  T P    P      S + PK            +P P T  +   P+++++P     
Sbjct: 456  EPAPTTPKEPAPTTTKEPSPTTPK------------EPAPTTTKS--APTTTKEPAPTTT 501

Query: 907  EDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPK 966
            +    +P+  +    KEP P  PK     T             +    +T  +    +PK
Sbjct: 502  KSAPTTPKEPSPTTTKEPAPTTPKEPAPTT------------PKKPAPTTPKEPAPTTPK 549

Query: 967  AQPGSTDRHASPARP----PAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSR 1022
                +T +  +P  P    P    +  P+ P+++TP   P++  P    T+   P P + 
Sbjct: 550  EPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP-TTPEKLAP----TTPEKPAPTTP 604

Query: 1023 D--AGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYD 1080
            +  A  +P +P  +  +   P        ++  +P   + +   PT              
Sbjct: 605  EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT------------- 651

Query: 1081 DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR 1140
                                KE A + PK     +P G                      
Sbjct: 652  -------------------PKEPAPTTPKETAPTTPKGTAP------------------- 673

Query: 1141 PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV 1200
                 +  + P+   P K  P    P ++K   S + +                  + + 
Sbjct: 674  -----TTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 728

Query: 1201 PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR 1260
            PK P+ +TP+G          +E  P     P    LAP     P    S   A   P  
Sbjct: 729  PKEPAPTTPKG----TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 784

Query: 1261 LPPRSAATVSPVAGTHPWPQYTTRAPPGHFS--TTPMLSLRQRMMHARFRNPLSRQPARP 1318
              P +    +P     P P  T   PP   S  +TP  +     +H           A P
Sbjct: 785  TAPTTPKEPAPTTPKKPAPT-TPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEP 843

Query: 1319 SYRQGYNG--RPNVEGKVLPGSN---------GKPNGQRIINGPQGTKWVVDLDRGLVLN 1367
            + +   N    P V     P +           K   + +   P+ T     + +     
Sbjct: 844  TPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATT 903

Query: 1368 AEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPIL 1427
             E              K      T    + T   + D  P        T LA     P +
Sbjct: 904  TE--------------KTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLA-----PKV 944

Query: 1428 SLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTT--- 1484
            +   K +   E++ K   P  T       T    TT  P+  T   ++ T+T++  T   
Sbjct: 945  TTTKKTITTTEIMNK---PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPR 1001

Query: 1485 -RRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEF 1543
             R+P TT      T+T     PT+ I      T  R +   N     + + E   + ++ 
Sbjct: 1002 VRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPN-----SKLVEVNPKSEDA 1056

Query: 1544 SGLETDT 1550
             G E +T
Sbjct: 1057 GGAEGET 1063



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 148/748 (19%), Positives = 230/748 (30%), Gaps = 139/748 (18%)

Query: 895  PSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQ 954
            PSS + P   G      + Q   S  ++ P P N K T        K        ++   
Sbjct: 73   PSSKKAPPPSG------ASQTIKSTTKRSPKPPNKKKTK-------KVIESEEITEEHSV 119

Query: 955  STDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVP----RRMTPGRAPQQQPP--- 1007
            S + ++   S  +   ST R    ++  AA  +    +     ++    + P  +PP   
Sbjct: 120  SENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVD 179

Query: 1008 ---------------PPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSS 1052
                           P  +T+QH+         +  + P+++  +   PRP+    S +S
Sbjct: 180  EAGSGLDNGDFKVTTPDTSTTQHN---------KVSTSPKITTAKPINPRPSLPPNSDTS 230

Query: 1053 SDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQ 1112
             +     ++       +    + Q S D       A++ ++      AK+ A   P  + 
Sbjct: 231  KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQS-IEKTSAKDLA---PTSKV 286

Query: 1113 VESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQ 1172
            +  PT         + +G A +  +   P  P+          P  + P    P + KS 
Sbjct: 287  LAKPTPKA----ETTTKGPALTTPKEPTPTTPKE---------PASTTPKEPTPTTIKS- 332

Query: 1173 QSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAP 1232
                                    + + PK P+ +T +         A    +      P
Sbjct: 333  ------------------------APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 368

Query: 1233 RGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPV--AGTHPW-PQYTTRAPPGH 1289
            +  +    K P P    S+P     P+   P+  A  +P   A T P  P  TT   P  
Sbjct: 369  KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 428

Query: 1290 FSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIIN 1349
             +  P  +  +       + P    P  P+        P    +  P +  +P      +
Sbjct: 429  TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKS 488

Query: 1350 GPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLF 1409
             P  TK                        P   K           E +P  + +  P  
Sbjct: 489  APTTTK---------------------EPAPTTTK----SAPTTPKEPSPTTTKEPAPT- 522

Query: 1410 GQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPT 1469
                  TP   A   P       P        K    PTTT +P  TT   P  TTP+ T
Sbjct: 523  ------TPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTPKEPAPTTPKET 575

Query: 1470 TATTRR--TTTTRR----TTTRRPTTTVRTTTRTTTTTTPTPTT---PIPTCPPGTLERH 1520
              TT +  T TT      TT  +P  T       TT   PTPTT   P PT P       
Sbjct: 576  APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNT 635

Query: 1521 DDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRP------PT 1574
              +          P    E    +  ET    P   A     E       +P      PT
Sbjct: 636  PKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 695

Query: 1575 TT-EP-STTATTPRVIPEEGAISSFPEE 1600
            TT EP STT   P     +G   + P+E
Sbjct: 696  TTKEPTSTTCDKPAPTTPKGTAPTTPKE 723



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 153/865 (17%), Positives = 278/865 (32%), Gaps = 128/865 (14%)

Query: 339  QGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILS 398
            Q   DGK  T+  + T     T+A +      V  KPT         P+ E   K     
Sbjct: 254  QTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT---------PKAETTTK----- 299

Query: 399  YAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTS 458
              PAL      + T P +  S       P      K   T  +   P +     + PTT 
Sbjct: 300  -GPALTTPKEPTPTTPKEPASTTPKEPTPTT---IKSAPTTPKEPAPTTTK---SAPTTP 352

Query: 459  KADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGG 518
            K      T++       EP+  + + PA +   S P +P+                    
Sbjct: 353  KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK------------------EP 394

Query: 519  APRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVA 578
            AP  P+   K A     +    T +E   +   +P  P+ T  +     P      +   
Sbjct: 395  APTTPK---KPAPTTPKEPAPTTPKEPTPT---TPKEPAPTTKEPAPTTPKEPAPTAPKK 448

Query: 579  PGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPAS 638
            P  T  +   P  P+     +P  +   +P P  P   + +    A T      P+   S
Sbjct: 449  PAPTTPKEPAPTTPK-----EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 503

Query: 639  LNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPAS--- 695
                    S    +      PK    +P P  +P + +P++      +      P +   
Sbjct: 504  APTTPKEPSPTTTKEPAPTTPK----EPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKK 558

Query: 696  PARRTPHSGA-AEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATN 754
            PA  TP   A      +A   P +L+P      +L PT P   +P +      E+   T 
Sbjct: 559  PAPTTPKEPAPTTPKETAPTTPKKLTPT--TPEKLAPTTPEKPAPTTP-----EELAPTT 611

Query: 755  SNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPAS 814
               P+ +T                E A  +   +  +  +E      +  A T    PA 
Sbjct: 612  PEEPTPTT--------------PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA- 656

Query: 815  GHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSG 874
                     P      +P   +  +G        P  T P +  P+  + + +    S+ 
Sbjct: 657  ---------PTTPKETAP---TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 704

Query: 875  IHGDEEDEKPLPATVVNDHVPSSSRQPI-SRGWEDLRRSPQRGASLHRKEPIPENPKSTG 933
                   +KP P T      P++ ++P  +   E    +P+  A    KEP P  PK   
Sbjct: 705  C------DKPAP-TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 757

Query: 934  ----ADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQ-- 987
                A T  +G  S+ + K         A T    P           +P  PP   S+  
Sbjct: 758  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 817

Query: 988  -----QHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPR 1042
                 + P+   +      P+    P     ++ P        ++P+  +  +T   + +
Sbjct: 818  TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 877

Query: 1043 PTSQGRSHSSSDPYTASSRGMLPTALQNQ----------DEDAQGSYDDDSTEVEAQDVR 1092
             T++    ++ +  TA+ +    TA   +                +   D+T  +   ++
Sbjct: 878  -TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 936

Query: 1093 APAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPS 1152
                A +      ++   + +  P       D R+    A +P    +P  P    + P+
Sbjct: 937  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKD-RATNSKATTP----KPQKPTKAPKKPT 991

Query: 1153 RAAPGKSEPPSKRPLSSKSQQSVSA 1177
                 K+ P  ++P ++ + + +++
Sbjct: 992  STKKPKTMPRVRKPKTTPTPRKMTS 1016


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 185/922 (20%), Positives = 312/922 (33%), Gaps = 117/922 (12%)

Query: 703  SGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSP---LSKGGKDGEDAPATNSNAPS 759
            S  AE  +  S P S+ +PP  G+S+ + +    S       K  K  E    T  ++ S
Sbjct: 102  SFCAEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVS 161

Query: 760  RSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHL 819
             +  SSS SS  SS + + +   + +  ++ +  ++   +  +      +  P       
Sbjct: 162  ENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTP------- 214

Query: 820  LRHKP----FAANGRSPSRFSI-----GRGPRLQPSSSPQSTV--PSRAHPRVPSHSDSH 868
               KP     A +G     F +           + S+SP+ T   P    P +P +SD+ 
Sbjct: 215  ---KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTS 271

Query: 869  PKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPEN 928
             + S  ++ +         TV      ++++Q  + G E       +  S    + I   
Sbjct: 272  KETSLTVNKE--------TTVETKETTTTNKQTSTDGKE-------KTTSAKETQSIE-- 314

Query: 929  PKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQ 988
             K++  D  P  K  +  +   +      A T    P           +P  P     + 
Sbjct: 315  -KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKS 373

Query: 989  HPSVPRRMTPG--RAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQ 1046
             P+ P+   P   ++    P  P  T+   P P +      P +P  + T+   P  T  
Sbjct: 374  APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT------PKEPAPTTTKEPAPTTTKS 427

Query: 1047 GRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAAS 1106
              + +  +P   + +   PT  +             + +  A   + PA     KE A +
Sbjct: 428  APT-TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT-PKEPAPT 485

Query: 1107 LPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRP 1166
             PK     +P          + +  A +  +   P  P+  A   +++AP  ++ P+  P
Sbjct: 486  APKKPAPTTPKEPAP----TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPA--P 539

Query: 1167 LSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEE--- 1223
             ++KS  +   E             KE   + + PK P+ +TP   K    +  KE    
Sbjct: 540  TTTKSAPTTPKEPSPTTT-------KEP--APTTPKEPAPTTP---KKPAPTTPKEPAPT 587

Query: 1224 --REPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWP-- 1279
              +EPA     +     P K P P  P  +  A   P +L P +   ++P     P P  
Sbjct: 588  TPKEPAPTTTKKPAPTTP-KEPAPTTPKET--APTTPKKLTPTTPEKLAPTTPEKPAPTT 644

Query: 1280 ----------QYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPN 1329
                      + T   P     TTP  +          + P    P  P+        P 
Sbjct: 645  PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP-----KEPAPTTPKEPAPTTPKEPAPT 699

Query: 1330 VEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDG 1389
               +  P +  K      +  P  T       + L           +   P      G  
Sbjct: 700  TPKETAP-TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 758

Query: 1390 RTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTT 1449
             T    E  P    +  P   +G   T L             K L            PTT
Sbjct: 759  PT-TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-----------PTT 806

Query: 1450 TMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPI 1509
            T  PT+TT+  P  TTP+ T  TT +      TT ++P  T   T   TT+   TPTT  
Sbjct: 807  TKGPTSTTSDKPAPTTPKETAPTTPKEPAP--TTPKKPAPTTPETPPPTTSEVSTPTT-- 862

Query: 1510 PTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGL-ETDTAVPTEEAYVIYDEDYEFE 1568
             T  P T+ +  D+    +S+   P+      +  G+  T T   T+       +D   +
Sbjct: 863  -TKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD---K 918

Query: 1569 TSRPPTTTEPSTTATTPRVIPE 1590
            T+     T P TT   P++  E
Sbjct: 919  TTERDLRTTPETTTAAPKMTKE 940



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 191/986 (19%), Positives = 319/986 (32%), Gaps = 160/986 (16%)

Query: 610  PGAPPSASASPAHHASTQG----TSHRPSLPASLNDNDLVDSDE--DERAVGSLHPKGAF 663
            P +PPS+  +P    ++Q     T   P  P       +++S+E  +E +V       + 
Sbjct: 110  PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 169

Query: 664  AQPRPALSPSRQSPSSV-------LRDRSSVHPGAKPASPARRTPHSGAAEEDSSAS--- 713
            +    + S  R+  SS        L+ +  V    K  +  + TP     +E  S     
Sbjct: 170  SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 229

Query: 714  ----APPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSS 769
                  P   +  H   S         +SP     K     P+   N+ +    S +V+ 
Sbjct: 230  DFKVTTPDTSTTQHNKVS---------TSPKITTAKPINPRPSLPPNSDTSKETSLTVNK 280

Query: 770  HLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANG 829
              +  T+ +     ++ ++  DG  +    +   + +   A+  +    +L  KP     
Sbjct: 281  ETTVETKETT---TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA-KP----- 331

Query: 830  RSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATV 889
             +P   +  +GP L     P  T P       P                   ++P P T+
Sbjct: 332  -TPKAETTTKGPALTTPKEPTPTTPKEPASTTP-------------------KEPTPTTI 371

Query: 890  VNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKA 949
             +   P++ ++P     +    +P+  A    KEP P  PK     T  +   ++  S  
Sbjct: 372  KS--APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP 429

Query: 950  QDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPP 1009
                 +T  +    +PK    +T +  +P  P     +  P+ P+      AP  + P P
Sbjct: 430  -----TTPKEPAPTTPKKPAPTTPKEPAPTTP----KEPTPTTPKEP----APTTKEPAP 476

Query: 1010 VATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQ 1069
                +  P    + A  +P +P  +  +   P  T +    +  +P   +++   PT  +
Sbjct: 477  TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA-PTTTK 535

Query: 1070 NQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQ-----QVESPTGAGAGGD 1124
                    S      E      + PA     KE A + PK       +  +PT       
Sbjct: 536  EPAPTTTKSAPTTPKEPSPTTTKEPAPTT-PKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 594

Query: 1125 HRSQRGHAASPARPSRPGGPQSRARVPSR-----------AAPGKSEPPSKRPLSSKSQQ 1173
              +++    +P  P+     ++    P +             P K  P +   L+  + +
Sbjct: 595  TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 654

Query: 1174 SVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKE----------- 1222
              +    EE      K    +      P  P    P   K+   +  KE           
Sbjct: 655  EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 714

Query: 1223 ----EREPAIALAPRGGSLAPVK----------RPLPPPP-GSSPRASHVPSRLPPRSAA 1267
                E  P     P    LAP            +P P  P G++P     P+   P+  A
Sbjct: 715  TTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPA 774

Query: 1268 TVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGR 1327
              +P  GT P    TT   P    TTP     + +     + P S    +P+        
Sbjct: 775  PTTP-KGTAP----TTLKEPA--PTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETA 827

Query: 1328 PNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGG 1387
            P    +  P +  KP        P  T  V                  +   P  I    
Sbjct: 828  PTTPKEPAPTTPKKPAPTTPETPPPTTSEVST--------------PTTTKEPTTIHKSP 873

Query: 1388 DGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPP 1447
            D       E TP +S +  P   +     P       P  +   KP +      KTT   
Sbjct: 874  D-------ESTPELSAEPTPKALENSPKEPGVPTTKTPAAT---KPEMTTTAKDKTTERD 923

Query: 1448 TTTMQPTTTTTPLPT---------TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTT--- 1495
              T   TTT  P  T         TT  + T  TT+ T+TT + TT    TT++TTT   
Sbjct: 924  LRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAP 983

Query: 1496 RTTTTTTPTPTTPIPTCPPGTLERHD 1521
            + TTT     TT I   P  T +  D
Sbjct: 984  KVTTTKKTITTTEIMNKPEETAKPKD 1009



 Score = 82.4 bits (202), Expect = 4e-15
 Identities = 213/1147 (18%), Positives = 352/1147 (30%), Gaps = 202/1147 (17%)

Query: 435  IRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVP 494
            I++T +R   P +K       T    + E+ TE++   E  E SS S  + +SS    + 
Sbjct: 129  IKSTTKRSPKPPNKK-----KTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIK 183

Query: 495  ASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPM 554
            +S      ++L   LK K        +KP  +    +E                      
Sbjct: 184  SSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAG-------------------- 223

Query: 555  SPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRAR----MPALPRREGVDKPGFSLATQPRP 610
            S  D  D K T    S   H+ V+       A+     P+LP      K   SL      
Sbjct: 224  SGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET-SLTVNKET 282

Query: 611  GAPPSASASPAHHASTQGTSHRPSLPA--SLNDNDLVDSDEDERAVGSLHPKGAFAQPRP 668
                  + +     ST G     S     S+      D     + +    PK       P
Sbjct: 283  TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 342

Query: 669  ALS-PSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSS 727
            AL+ P   +P++             P  PA  TP         SA   P   +P    ++
Sbjct: 343  ALTTPKEPTPTT-------------PKEPASTTPKEPTPTTIKSAPTTPKEPAPT---TT 386

Query: 728  RLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGE 787
            +  PT P   +P +      E AP T       +T   + ++  S+ T   E A  +  +
Sbjct: 387  KSAPTTPKEPAPTTTK----EPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKK 442

Query: 788  SHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSS 847
                  +E      +    T    PA         +P     + P+  +  + P      
Sbjct: 443  PAPTTPKEPAPTTPKEPTPTTPKEPAP-----TTKEPAPTTPKEPAP-TAPKKPAPTTPK 496

Query: 848  SPQSTVPSRAHPRVPSH-SDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGW 906
             P  T P    P      S + PK            +P P T  +   P+++++P     
Sbjct: 497  EPAPTTPKEPAPTTTKEPSPTTPK------------EPAPTTTKS--APTTTKEPAPTTT 542

Query: 907  EDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPK 966
            +    +P+  +    KEP P  PK     T             +    +T  +    +PK
Sbjct: 543  KSAPTTPKEPSPTTTKEPAPTTPKEPAPTT------------PKKPAPTTPKEPAPTTPK 590

Query: 967  AQPGSTDRHASPARP----PAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSR 1022
                +T +  +P  P    P    +  P+ P+++TP   P++  P    T+   P P + 
Sbjct: 591  EPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP-TTPEKLAP----TTPEKPAPTTP 645

Query: 1023 D--AGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYD 1080
            +  A  +P +P  +  +   P        ++  +P   + +   PT              
Sbjct: 646  EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT------------- 692

Query: 1081 DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR 1140
                                KE A + PK     +P G                      
Sbjct: 693  -------------------PKEPAPTTPKETAPTTPKGTAP------------------- 714

Query: 1141 PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV 1200
                 +  + P+   P K  P    P ++K   S + +                  + + 
Sbjct: 715  -----TTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 769

Query: 1201 PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR 1260
            PK P+ +TP+G          +E  P     P    LAP     P    S   A   P  
Sbjct: 770  PKEPAPTTPKG----TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 825

Query: 1261 LPPRSAATVSPVAGTHPWPQYTTRAPPGHFS--TTPMLSLRQRMMHARFRNPLSRQPARP 1318
              P +    +P     P P  T   PP   S  +TP  +     +H           A P
Sbjct: 826  TAPTTPKEPAPTTPKKPAPT-TPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEP 884

Query: 1319 SYRQGYNG--RPNVEGKVLPGSN---------GKPNGQRIINGPQGTKWVVDLDRGLVLN 1367
            + +   N    P V     P +           K   + +   P+ T     + +     
Sbjct: 885  TPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATT 944

Query: 1368 AEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPIL 1427
             E              K      T    + T   + D  P        T LA     P +
Sbjct: 945  TE--------------KTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLA-----PKV 985

Query: 1428 SLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTT--- 1484
            +   K +   E++ K   P  T       T    TT  P+  T   ++ T+T++  T   
Sbjct: 986  TTTKKTITTTEIMNK---PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPR 1042

Query: 1485 -RRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEF 1543
             R+P TT      T+T     PT+ I      T  R +   N     + + E   + ++ 
Sbjct: 1043 VRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPN-----SKLVEVNPKSEDA 1097

Query: 1544 SGLETDT 1550
             G E +T
Sbjct: 1098 GGAEGET 1104



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 148/748 (19%), Positives = 230/748 (30%), Gaps = 139/748 (18%)

Query: 895  PSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQ 954
            PSS + P   G      + Q   S  ++ P P N K T        K        ++   
Sbjct: 114  PSSKKAPPPSG------ASQTIKSTTKRSPKPPNKKKTK-------KVIESEEITEEHSV 160

Query: 955  STDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVP----RRMTPGRAPQQQPP--- 1007
            S + ++   S  +   ST R    ++  AA  +    +     ++    + P  +PP   
Sbjct: 161  SENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVD 220

Query: 1008 ---------------PPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSS 1052
                           P  +T+QH+         +  + P+++  +   PRP+    S +S
Sbjct: 221  EAGSGLDNGDFKVTTPDTSTTQHN---------KVSTSPKITTAKPINPRPSLPPNSDTS 271

Query: 1053 SDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQ 1112
             +     ++       +    + Q S D       A++ ++      AK+ A   P  + 
Sbjct: 272  KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQS-IEKTSAKDLA---PTSKV 327

Query: 1113 VESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQ 1172
            +  PT         + +G A +  +   P  P+          P  + P    P + KS 
Sbjct: 328  LAKPTPKA----ETTTKGPALTTPKEPTPTTPKE---------PASTTPKEPTPTTIKS- 373

Query: 1173 QSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAP 1232
                                    + + PK P+ +T +         A    +      P
Sbjct: 374  ------------------------APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 409

Query: 1233 RGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPV--AGTHPW-PQYTTRAPPGH 1289
            +  +    K P P    S+P     P+   P+  A  +P   A T P  P  TT   P  
Sbjct: 410  KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 469

Query: 1290 FSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIIN 1349
             +  P  +  +       + P    P  P+        P    +  P +  +P      +
Sbjct: 470  TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKS 529

Query: 1350 GPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLF 1409
             P  TK                        P   K           E +P  + +  P  
Sbjct: 530  APTTTK---------------------EPAPTTTK----SAPTTPKEPSPTTTKEPAPT- 563

Query: 1410 GQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPT 1469
                  TP   A   P       P        K    PTTT +P  TT   P  TTP+ T
Sbjct: 564  ------TPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTPKEPAPTTPKET 616

Query: 1470 TATTRR--TTTTRR----TTTRRPTTTVRTTTRTTTTTTPTPTT---PIPTCPPGTLERH 1520
              TT +  T TT      TT  +P  T       TT   PTPTT   P PT P       
Sbjct: 617  APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNT 676

Query: 1521 DDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRP------PT 1574
              +          P    E    +  ET    P   A     E       +P      PT
Sbjct: 677  PKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 736

Query: 1575 TT-EP-STTATTPRVIPEEGAISSFPEE 1600
            TT EP STT   P     +G   + P+E
Sbjct: 737  TTKEPTSTTCDKPAPTTPKGTAPTTPKE 764



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 153/865 (17%), Positives = 278/865 (32%), Gaps = 128/865 (14%)

Query: 339  QGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILS 398
            Q   DGK  T+  + T     T+A +      V  KPT         P+ E   K     
Sbjct: 295  QTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT---------PKAETTTK----- 340

Query: 399  YAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTS 458
              PAL      + T P +  S       P      K   T  +   P +     + PTT 
Sbjct: 341  -GPALTTPKEPTPTTPKEPASTTPKEPTPTT---IKSAPTTPKEPAPTTTK---SAPTTP 393

Query: 459  KADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGG 518
            K      T++       EP+  + + PA +   S P +P+                    
Sbjct: 394  KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK------------------EP 435

Query: 519  APRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVA 578
            AP  P+   K A     +    T +E   +   +P  P+ T  +     P      +   
Sbjct: 436  APTTPK---KPAPTTPKEPAPTTPKEPTPT---TPKEPAPTTKEPAPTTPKEPAPTAPKK 489

Query: 579  PGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPAS 638
            P  T  +   P  P+     +P  +   +P P  P   + +    A T      P+   S
Sbjct: 490  PAPTTPKEPAPTTPK-----EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 544

Query: 639  LNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPAS--- 695
                    S    +      PK    +P P  +P + +P++      +      P +   
Sbjct: 545  APTTPKEPSPTTTKEPAPTTPK----EPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKK 599

Query: 696  PARRTPHSGA-AEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATN 754
            PA  TP   A      +A   P +L+P      +L PT P   +P +      E+   T 
Sbjct: 600  PAPTTPKEPAPTTPKETAPTTPKKLTPT--TPEKLAPTTPEKPAPTTP-----EELAPTT 652

Query: 755  SNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPAS 814
               P+ +T                E A  +   +  +  +E      +  A T    PA 
Sbjct: 653  PEEPTPTT--------------PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA- 697

Query: 815  GHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSG 874
                     P      +P   +  +G        P  T P +  P+  + + +    S+ 
Sbjct: 698  ---------PTTPKETAP---TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 745

Query: 875  IHGDEEDEKPLPATVVNDHVPSSSRQPI-SRGWEDLRRSPQRGASLHRKEPIPENPKSTG 933
                   +KP P T      P++ ++P  +   E    +P+  A    KEP P  PK   
Sbjct: 746  C------DKPAP-TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 798

Query: 934  ----ADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQ-- 987
                A T  +G  S+ + K         A T    P           +P  PP   S+  
Sbjct: 799  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 858

Query: 988  -----QHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPR 1042
                 + P+   +      P+    P     ++ P        ++P+  +  +T   + +
Sbjct: 859  TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 918

Query: 1043 PTSQGRSHSSSDPYTASSRGMLPTALQNQ----------DEDAQGSYDDDSTEVEAQDVR 1092
             T++    ++ +  TA+ +    TA   +                +   D+T  +   ++
Sbjct: 919  -TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 977

Query: 1093 APAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPS 1152
                A +      ++   + +  P       D R+    A +P    +P  P    + P+
Sbjct: 978  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKD-RATNSKATTP----KPQKPTKAPKKPT 1032

Query: 1153 RAAPGKSEPPSKRPLSSKSQQSVSA 1177
                 K+ P  ++P ++ + + +++
Sbjct: 1033 STKKPKTMPRVRKPKTTPTPRKMTS 1057


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 156/767 (20%), Positives = 257/767 (33%), Gaps = 95/767 (12%)

Query: 846  SSSPQSTV--PSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPIS 903
            S+SP+ T   P    P +P +SD+  + S  ++ +         TV      ++++Q  +
Sbjct: 113  STSPKITTAKPINPRPSLPPNSDTSKETSLTVNKE--------TTVETKETTTTNKQTST 164

Query: 904  RGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGH 963
             G E       +  S    + I    K++  D  P  K  +  +   +      A T   
Sbjct: 165  DGKE-------KTTSAKETQSIE---KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 214

Query: 964  SPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPG--RAPQQQPPPPVATSQHHPGPQS 1021
             P           +P  P     +  P+ P+   P   ++    P  P  T+   P P +
Sbjct: 215  EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 274

Query: 1022 RDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDD 1081
                  P +P  + T+   P  T    + +  +P   + +   PT  +            
Sbjct: 275  ------PKEPAPTTTKEPAPTTTKSAPT-TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP 327

Query: 1082 DSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRP 1141
             + +  A   + PA     KE A + PK     +P          + +  A +  +   P
Sbjct: 328  TTPKEPAPTTKEPAPTT-PKEPAPTAPKKPAPTTPKEPAP----TTPKEPAPTTTKEPSP 382

Query: 1142 GGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVP 1201
              P+  A   +++AP  ++ P+  P ++KS  +   E             KE   + + P
Sbjct: 383  TTPKEPAPTTTKSAPTTTKEPA--PTTTKSAPTTPKEPSPTTT-------KEP--APTTP 431

Query: 1202 KWPSSSTPRGGKDADGSLAKEE-----REPAIALAPRGGSLAPVKRPLPPPPGSSPRASH 1256
            K P+ +TP   K    +  KE      +EPA     +     P K P P  P  +  A  
Sbjct: 432  KEPAPTTP---KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP-KEPAPTTPKET--APT 485

Query: 1257 VPSRLPPRSAATVSPVAGTHPWP------------QYTTRAPPGHFSTTPMLSLRQRMMH 1304
             P +L P +   ++P     P P            + T   P     TTP  +       
Sbjct: 486  TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP-- 543

Query: 1305 ARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGL 1364
               + P    P  P+        P    +  P +  K      +  P  T       + L
Sbjct: 544  ---KEPAPTTPKEPAPTTPKEPAPTTPKETAP-TTPKGTAPTTLKEPAPTTPKKPAPKEL 599

Query: 1365 VLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDK 1424
                       +   P      G   T    E  P    +  P   +G   T L      
Sbjct: 600  APTTTKEPTSTTCDKPAPTTPKGTAPT-TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 658

Query: 1425 PILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTT 1484
                   K L            PTTT  PT+TT+  P  TTP+ T  TT +      TT 
Sbjct: 659  TPKKPAPKELA-----------PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP--TTP 705

Query: 1485 RRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFS 1544
            ++P  T   T   TT+   TPTT   T  P T+ +  D+    +S+   P+      +  
Sbjct: 706  KKPAPTTPETPPPTTSEVSTPTT---TKEPTTIHKSPDESTPELSAEPTPKALENSPKEP 762

Query: 1545 GL-ETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPE 1590
            G+  T T   T+       +D   +T+     T P TT   P++  E
Sbjct: 763  GVPTTKTPAATKPEMTTTAKD---KTTERDLRTTPETTTAAPKMTKE 806



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 150/745 (20%), Positives = 237/745 (31%), Gaps = 121/745 (16%)

Query: 831  SPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVV 890
            +P   +  +GP L     P  T P       P                   ++P P T+ 
Sbjct: 198  TPKAETTTKGPALTTPKEPTPTTPKEPASTTP-------------------KEPTPTTIK 238

Query: 891  NDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQ 950
            +   P++ ++P     +    +P+  A    KEP P  PK     T  +   ++  S   
Sbjct: 239  S--APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP- 295

Query: 951  DVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPV 1010
                +T  +    +PK    +T +  +P  P     +  P+ P+      AP  + P P 
Sbjct: 296  ----TTPKEPAPTTPKKPAPTTPKEPAPTTP----KEPTPTTPKEP----APTTKEPAPT 343

Query: 1011 ATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQN 1070
               +  P    + A  +P +P  +  +   P  T +    +  +P   +++   PT  + 
Sbjct: 344  TPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA-PTTTKE 402

Query: 1071 QDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQ-----QVESPTGAGAGGDH 1125
                   S      E      + PA     KE A + PK       +  +PT        
Sbjct: 403  PAPTTTKSAPTTPKEPSPTTTKEPAPTT-PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT 461

Query: 1126 RSQRGHAASPARPSRPGGPQSRARVPSR-----------AAPGKSEPPSKRPLSSKSQQS 1174
             +++    +P  P+     ++    P +             P K  P +   L+  + + 
Sbjct: 462  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 521

Query: 1175 VSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKE------------ 1222
             +    EE      K    +      P  P    P   K+   +  KE            
Sbjct: 522  PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT 581

Query: 1223 ---EREPAIALAPRGGSLAPVK----------RPLPPPP-GSSPRASHVPSRLPPRSAAT 1268
               E  P     P    LAP            +P P  P G++P     P+   P+  A 
Sbjct: 582  TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 641

Query: 1269 VSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRP 1328
             +P  GT P    TT   P    TTP     + +     + P S    +P+        P
Sbjct: 642  TTP-KGTAP----TTLKEPA--PTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 694

Query: 1329 NVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGD 1388
                +  P +  KP        P  T  V                  +   P  I    D
Sbjct: 695  TTPKEPAPTTPKKPAPTTPETPPPTTSEVST--------------PTTTKEPTTIHKSPD 740

Query: 1389 GRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPT 1448
                   E TP +S +  P   +     P       P  +   KP +      KTT    
Sbjct: 741  -------ESTPELSAEPTPKALENSPKEPGVPTTKTPAAT---KPEMTTTAKDKTTERDL 790

Query: 1449 TTMQPTTTTTPLPT---------TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTT---R 1496
             T   TTT  P  T         TT  + T  TT+ T+TT + TT    TT++TTT   +
Sbjct: 791  RTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPK 850

Query: 1497 TTTTTTPTPTTPIPTCPPGTLERHD 1521
             TTT     TT I   P  T +  D
Sbjct: 851  VTTTKKTITTTEIMNKPEETAKPKD 875



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 171/869 (19%), Positives = 271/869 (31%), Gaps = 120/869 (13%)

Query: 666  PRPALSP-SRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHG 724
            PRP+L P S  S  + L          K  +   +   +   E+ +SA    S       
Sbjct: 126  PRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT--- 182

Query: 725  GSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEAS 784
             +  L PT   L+ P  K     +    T    P+ +T     S+     T  +  +  +
Sbjct: 183  SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 242

Query: 785  DGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQ 844
              +       +      +  A T    PA         +P     + P+  +    P   
Sbjct: 243  TPKEPAPTTTKSAPTTPKEPAPTTTKEPAP----TTPKEPAPTTTKEPAPTTTKSAPTTP 298

Query: 845  PSSSPQSTVPSRAHPRVPSH-SDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPIS 903
               +P  T P +  P  P   + + PK  +     E      PA    +  P++ ++P  
Sbjct: 299  KEPAP--TTPKKPAPTTPKEPAPTTPKEPTPTTPKE------PAPTTKEPAPTTPKEPAP 350

Query: 904  RGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGH 963
                    +P++ A    KEP P  PK     T  +   ++    A    +S    T+  
Sbjct: 351  T-------APKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK-- 401

Query: 964  SPKAQPGSTDRHASPARP----PAARSQQHPSVPRR---MTPGRAPQQQPPPPVATSQHH 1016
                +P  T   ++P  P    P    +  P+ P+     TP +     P  P  T+   
Sbjct: 402  ----EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 457

Query: 1017 PGPQS--RDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDED 1074
            P P +  + A  +P +P  + T      PT+  +   ++    A +    P     ++  
Sbjct: 458  PAPTTTKKPAPTTPKEP--APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 515

Query: 1075 AQGSYDDDSTEVEAQDVRAPAHAA--RAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHA 1132
                 +   T  E      P  AA    KE A + PK     +P            +  A
Sbjct: 516  PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP------------KEPA 563

Query: 1133 ASPARPSRPGGPQSRA----RVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFF 1188
             +  + + P  P+  A    + P+   P K  P    P ++K   S + +          
Sbjct: 564  PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 623

Query: 1189 KGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPP 1248
                    + + PK P+ +TP+G          +E  P     P    LAP     P   
Sbjct: 624  APTTPKEPAPTTPKEPAPTTPKG----TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTST 679

Query: 1249 GSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFS-TTPMLSLRQRMMHARF 1307
             S   A   P    P +    +P     P P      PP     +TP  +     +H   
Sbjct: 680  TSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP 739

Query: 1308 RNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLN 1367
                    A P+             K L  S  +P G      P  TK            
Sbjct: 740  DESTPELSAEPT------------PKALENSPKEP-GVPTTKTPAATK------------ 774

Query: 1368 AEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPIL 1427
                        P       D  T  DL  TP  +     +  +       A   +K   
Sbjct: 775  ------------PEMTTTAKDKTTERDLRTTPETTTAAPKMTKE------TATTTEKTTE 816

Query: 1428 SLGGKPLVGLEVIKKTTHPPTTTMQPTT--TTTPLPTTTTPRPTTATTRRTTTTRRTTTR 1485
            S         ++   TT   +TT Q TT    T L TTT   P   TT++T TT      
Sbjct: 817  S---------KITATTTQVTSTTTQDTTPFKITTLKTTTL-APKVTTTKKTITTTE-IMN 865

Query: 1486 RPTTTVRTTTRTTTTTTPTPTTPIPTCPP 1514
            +P  T +   R T +   TP    PT  P
Sbjct: 866  KPEETAKPKDRATNSKATTPKPQKPTKAP 894



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 130/733 (17%), Positives = 246/733 (33%), Gaps = 103/733 (14%)

Query: 460  ADVEQNTEDNGKPEKPEPSSP----------------SPRAPASSQHPSVPASPQGRNAK 503
            A+V+ N ++  K +KP P  P                +    +++QH  V  SP+   AK
Sbjct: 64   AEVKDNKKNRTK-KKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAK 122

Query: 504  DLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQK 563
             +  + +  +  N    ++  L   K   ++ + T  T ++     ++   S  +TQ  +
Sbjct: 123  PI--NPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIE 180

Query: 564  RT------------LRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPG 611
            +T             +P  +   +   P  T  +   P  P+     +P  +   +P P 
Sbjct: 181  KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPK-----EPASTTPKEPTPT 235

Query: 612  APPSASASPAHHA--STQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPA 669
               SA  +P   A  +T+     P  PA     +   +   E A  +             
Sbjct: 236  TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP 295

Query: 670  LSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRL 729
             +P   +P++  +   +      P +P   TP +   +E +  +  P+  +P     +  
Sbjct: 296  TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT--PKEPAPTTKEPAPTTPKEPAPTA- 352

Query: 730  LPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESH 789
             P +P  ++P        ++   T +  PS +T      +   S    ++    +  +S 
Sbjct: 353  -PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 411

Query: 790  GDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSP 849
                +E      +  A T    PA         KP     + P+  +  + P    +  P
Sbjct: 412  PTTPKEPSPTTTKEPAPTTPKEPAP----TTPKKPAPTTPKEPAP-TTPKEPAPTTTKKP 466

Query: 850  QSTVPSRAHPRVPSHS-DSHPKLSSGIHGDE----EDEKPLPAT-------VVNDHVPSS 897
              T P    P  P  +  + PK  +    ++      EKP P T          +  P++
Sbjct: 467  APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 526

Query: 898  SRQPI---------SRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSS---- 944
              +P          +   E    +P+  A    KEP P  PK T A T P+G   +    
Sbjct: 527  PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKET-APTTPKGTAPTTLKE 585

Query: 945  -------------LASKAQDVQQSTDAD---------TEGHSPKAQPGSTDRHASPARP- 981
                         LA        ST  D         T   +PK    +T +  +P  P 
Sbjct: 586  PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 645

Query: 982  ---PAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQS--RDAGRSPSQPRLSLT 1036
               P    +  P+ P++  P          P +T+   P P +    A  +P +P  + T
Sbjct: 646  GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP--APT 703

Query: 1037 QAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAH 1096
               +P PT+      ++   +  +    PT +    +++      + T    ++      
Sbjct: 704  TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 763

Query: 1097 AARAKEAAASLPK 1109
                K  AA+ P+
Sbjct: 764  VPTTKTPAATKPE 776



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 133/692 (19%), Positives = 196/692 (28%), Gaps = 97/692 (14%)

Query: 924  PIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARP-- 981
            P  +  K T    + +    +  +   + Q STD   +  S K         A    P  
Sbjct: 132  PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTS 191

Query: 982  -----PAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQS-RDAGRSPSQPRLSL 1035
                 P  +++     P   TP       P  P +T+   P P + + A  +P +P  + 
Sbjct: 192  KVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTT 251

Query: 1036 TQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPA 1095
            T++    P     + ++ +P   + +   PT                 T  E       +
Sbjct: 252  TKSAPTTPKEPAPT-TTKEPAPTTPKEPAPT-----------------TTKEPAPTTTKS 293

Query: 1096 HAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAA 1155
                 KE A + PK     +P                 +P  P  P     +   P+   
Sbjct: 294  APTTPKEPAPTTPKKPAPTTPK--------------EPAPTTPKEPTPTTPKEPAPTTKE 339

Query: 1156 PGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDA 1215
            P  + P    P + K     + ++                     P  P    P   K+ 
Sbjct: 340  PAPTTPKEPAPTAPKKPAPTTPKEP-------------------APTTPKEPAPTTTKEP 380

Query: 1216 DGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGT 1275
              +  KE        AP        K P P    S+P     PS   P +    +P    
Sbjct: 381  SPTTPKEPAPTTTKSAP-----TTTKEPAPTTTKSAPTTPKEPS---PTTTKEPAPTTPK 432

Query: 1276 HPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVL 1335
             P P  T + P       P  +  +       + P    P  P+        P    K+ 
Sbjct: 433  EPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLT 491

Query: 1336 PGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDL 1395
            P +  K         P+        +       E          P   K           
Sbjct: 492  PTTPEK----LAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPA 547

Query: 1396 EGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPP-------T 1448
              TP       P     +   P    +  P    G  P    E    T   P       T
Sbjct: 548  PTTPKEPAPTTP-----KEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 602

Query: 1449 TTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTP 1508
            TT +PT+TT   P  TTP+ T  TT +      TT + P  T    T  TT   P PTTP
Sbjct: 603  TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP--TTPKEPAPTTPKGTAPTTLKEPAPTTP 660

Query: 1509 IPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFE 1568
                P               S    P    E    +  E     P + A    +      
Sbjct: 661  KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPE------ 714

Query: 1569 TSRPPTTTEPSTTATTPRVIPEEGAISSFPEE 1600
             + PPTT+E ST  TT     E   I   P+E
Sbjct: 715  -TPPPTTSEVSTPTTT----KEPTTIHKSPDE 741



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 123/613 (20%), Positives = 187/613 (30%), Gaps = 104/613 (16%)

Query: 1008 PPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTA 1067
            P  +T+QH+         +  + P+++  +   PRP+    S +S +     ++      
Sbjct: 102  PDTSTTQHN---------KVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVET 152

Query: 1068 LQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRS 1127
             +    + Q S D       A++ ++      AK+ A   P  + +  PT         +
Sbjct: 153  KETTTTNKQTSTDGKEKTTSAKETQS-IEKTSAKDLA---PTSKVLAKPTPKA----ETT 204

Query: 1128 QRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGF 1187
             +G A +  +   P  P+          P  + P    P + KS                
Sbjct: 205  TKGPALTTPKEPTPTTPKE---------PASTTPKEPTPTTIKS---------------- 239

Query: 1188 FKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPP 1247
                     + + PK P+ +T +         A    +      P+  +    K P P  
Sbjct: 240  ---------APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 290

Query: 1248 PGSSPRASHVPSRLPPRSAATVS---PVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMH 1304
              S+P     P+   P+  A  +   P   T   P  TT   P   +  P  +  +    
Sbjct: 291  TKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 350

Query: 1305 ARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGL 1364
               + P    P  P+        P    +  P +  +P      + P  TK         
Sbjct: 351  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK--------- 401

Query: 1365 VLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDK 1424
                           P   K           E +P  + +  P        TP   A   
Sbjct: 402  ------------EPAPTTTK----SAPTTPKEPSPTTTKEPAPT-------TPKEPAPTT 438

Query: 1425 PILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATT--RRTTTTRR- 1481
            P       P        K    PTTT +P  TT   P  TTP+ T  TT  + T TT   
Sbjct: 439  PKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK 497

Query: 1482 ---TTTRRPTTTVRTTTRTTTTTTPTPTT---PIPTCPPGTLERHDDDGNLIMSSNGIPE 1535
               TT  +P  T       TT   PTPTT   P PT P         +          P 
Sbjct: 498  LAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 557

Query: 1536 CYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRP------PTTT-EP-STTATTPRV 1587
               E    +  ET    P   A     E       +P      PTTT EP STT   P  
Sbjct: 558  TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 617

Query: 1588 IPEEGAISSFPEE 1600
               +G   + P+E
Sbjct: 618  TTPKGTAPTTPKE 630



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 153/865 (17%), Positives = 278/865 (32%), Gaps = 128/865 (14%)

Query: 339  QGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILS 398
            Q   DGK  T+  + T     T+A +      V  KPT         P+ E   K     
Sbjct: 161  QTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT---------PKAETTTK----- 206

Query: 399  YAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTS 458
              PAL      + T P +  S       P      K   T  +   P +     + PTT 
Sbjct: 207  -GPALTTPKEPTPTTPKEPASTTPKEPTPTT---IKSAPTTPKEPAPTTTK---SAPTTP 259

Query: 459  KADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGG 518
            K      T++       EP+  + + PA +   S P +P+                    
Sbjct: 260  KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK------------------EP 301

Query: 519  APRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVA 578
            AP  P+   K A     +    T +E   +   +P  P+ T  +     P      +   
Sbjct: 302  APTTPK---KPAPTTPKEPAPTTPKEPTPT---TPKEPAPTTKEPAPTTPKEPAPTAPKK 355

Query: 579  PGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPAS 638
            P  T  +   P  P+     +P  +   +P P  P   + +    A T      P+   S
Sbjct: 356  PAPTTPKEPAPTTPK-----EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 410

Query: 639  LNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPAS--- 695
                    S    +      PK    +P P  +P + +P++      +      P +   
Sbjct: 411  APTTPKEPSPTTTKEPAPTTPK----EPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKK 465

Query: 696  PARRTPHSGA-AEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATN 754
            PA  TP   A      +A   P +L+P      +L PT P   +P +      E+   T 
Sbjct: 466  PAPTTPKEPAPTTPKETAPTTPKKLTPT--TPEKLAPTTPEKPAPTTP-----EELAPTT 518

Query: 755  SNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPAS 814
               P+ +T                E A  +   +  +  +E      +  A T    PA 
Sbjct: 519  PEEPTPTT--------------PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA- 563

Query: 815  GHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSG 874
                     P      +P   +  +G        P  T P +  P+  + + +    S+ 
Sbjct: 564  ---------PTTPKETAP---TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 611

Query: 875  IHGDEEDEKPLPATVVNDHVPSSSRQPI-SRGWEDLRRSPQRGASLHRKEPIPENPKSTG 933
                   +KP P T      P++ ++P  +   E    +P+  A    KEP P  PK   
Sbjct: 612  C------DKPAP-TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 664

Query: 934  ----ADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQ-- 987
                A T  +G  S+ + K         A T    P           +P  PP   S+  
Sbjct: 665  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 724

Query: 988  -----QHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPR 1042
                 + P+   +      P+    P     ++ P        ++P+  +  +T   + +
Sbjct: 725  TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 784

Query: 1043 PTSQGRSHSSSDPYTASSRGMLPTALQNQ----------DEDAQGSYDDDSTEVEAQDVR 1092
             T++    ++ +  TA+ +    TA   +                +   D+T  +   ++
Sbjct: 785  -TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 843

Query: 1093 APAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPS 1152
                A +      ++   + +  P       D R+    A +P    +P  P    + P+
Sbjct: 844  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKD-RATNSKATTP----KPQKPTKAPKKPT 898

Query: 1153 RAAPGKSEPPSKRPLSSKSQQSVSA 1177
                 K+ P  ++P ++ + + +++
Sbjct: 899  STKKPKTMPRVRKPKTTPTPRKMTS 923


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 156/767 (20%), Positives = 257/767 (33%), Gaps = 95/767 (12%)

Query: 846  SSSPQSTV--PSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPIS 903
            S+SP+ T   P    P +P +SD+  + S  ++ +         TV      ++++Q  +
Sbjct: 154  STSPKITTAKPINPRPSLPPNSDTSKETSLTVNKE--------TTVETKETTTTNKQTST 205

Query: 904  RGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGH 963
             G E       +  S    + I    K++  D  P  K  +  +   +      A T   
Sbjct: 206  DGKE-------KTTSAKETQSIE---KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 255

Query: 964  SPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPG--RAPQQQPPPPVATSQHHPGPQS 1021
             P           +P  P     +  P+ P+   P   ++    P  P  T+   P P +
Sbjct: 256  EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 315

Query: 1022 RDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDD 1081
                  P +P  + T+   P  T    + +  +P   + +   PT  +            
Sbjct: 316  ------PKEPAPTTTKEPAPTTTKSAPT-TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP 368

Query: 1082 DSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRP 1141
             + +  A   + PA     KE A + PK     +P          + +  A +  +   P
Sbjct: 369  TTPKEPAPTTKEPAPTT-PKEPAPTAPKKPAPTTPKEPAP----TTPKEPAPTTTKEPSP 423

Query: 1142 GGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVP 1201
              P+  A   +++AP  ++ P+  P ++KS  +   E             KE   + + P
Sbjct: 424  TTPKEPAPTTTKSAPTTTKEPA--PTTTKSAPTTPKEPSPTTT-------KEP--APTTP 472

Query: 1202 KWPSSSTPRGGKDADGSLAKEE-----REPAIALAPRGGSLAPVKRPLPPPPGSSPRASH 1256
            K P+ +TP   K    +  KE      +EPA     +     P K P P  P  +  A  
Sbjct: 473  KEPAPTTP---KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP-KEPAPTTPKET--APT 526

Query: 1257 VPSRLPPRSAATVSPVAGTHPWP------------QYTTRAPPGHFSTTPMLSLRQRMMH 1304
             P +L P +   ++P     P P            + T   P     TTP  +       
Sbjct: 527  TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP-- 584

Query: 1305 ARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGL 1364
               + P    P  P+        P    +  P +  K      +  P  T       + L
Sbjct: 585  ---KEPAPTTPKEPAPTTPKEPAPTTPKETAP-TTPKGTAPTTLKEPAPTTPKKPAPKEL 640

Query: 1365 VLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDK 1424
                       +   P      G   T    E  P    +  P   +G   T L      
Sbjct: 641  APTTTKEPTSTTCDKPAPTTPKGTAPT-TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPT 699

Query: 1425 PILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTT 1484
                   K L            PTTT  PT+TT+  P  TTP+ T  TT +      TT 
Sbjct: 700  TPKKPAPKELA-----------PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP--TTP 746

Query: 1485 RRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFS 1544
            ++P  T   T   TT+   TPTT   T  P T+ +  D+    +S+   P+      +  
Sbjct: 747  KKPAPTTPETPPPTTSEVSTPTT---TKEPTTIHKSPDESTPELSAEPTPKALENSPKEP 803

Query: 1545 GL-ETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPE 1590
            G+  T T   T+       +D   +T+     T P TT   P++  E
Sbjct: 804  GVPTTKTPAATKPEMTTTAKD---KTTERDLRTTPETTTAAPKMTKE 847



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 150/745 (20%), Positives = 237/745 (31%), Gaps = 121/745 (16%)

Query: 831  SPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVV 890
            +P   +  +GP L     P  T P       P                   ++P P T+ 
Sbjct: 239  TPKAETTTKGPALTTPKEPTPTTPKEPASTTP-------------------KEPTPTTIK 279

Query: 891  NDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQ 950
            +   P++ ++P     +    +P+  A    KEP P  PK     T  +   ++  S   
Sbjct: 280  S--APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP- 336

Query: 951  DVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPV 1010
                +T  +    +PK    +T +  +P  P     +  P+ P+      AP  + P P 
Sbjct: 337  ----TTPKEPAPTTPKKPAPTTPKEPAPTTP----KEPTPTTPKEP----APTTKEPAPT 384

Query: 1011 ATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQN 1070
               +  P    + A  +P +P  +  +   P  T +    +  +P   +++   PT  + 
Sbjct: 385  TPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA-PTTTKE 443

Query: 1071 QDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQ-----QVESPTGAGAGGDH 1125
                   S      E      + PA     KE A + PK       +  +PT        
Sbjct: 444  PAPTTTKSAPTTPKEPSPTTTKEPAPTT-PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT 502

Query: 1126 RSQRGHAASPARPSRPGGPQSRARVPSR-----------AAPGKSEPPSKRPLSSKSQQS 1174
             +++    +P  P+     ++    P +             P K  P +   L+  + + 
Sbjct: 503  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 562

Query: 1175 VSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKE------------ 1222
             +    EE      K    +      P  P    P   K+   +  KE            
Sbjct: 563  PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT 622

Query: 1223 ---EREPAIALAPRGGSLAPVK----------RPLPPPP-GSSPRASHVPSRLPPRSAAT 1268
               E  P     P    LAP            +P P  P G++P     P+   P+  A 
Sbjct: 623  TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 682

Query: 1269 VSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRP 1328
             +P  GT P    TT   P    TTP     + +     + P S    +P+        P
Sbjct: 683  TTP-KGTAP----TTLKEPA--PTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 735

Query: 1329 NVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGD 1388
                +  P +  KP        P  T  V                  +   P  I    D
Sbjct: 736  TTPKEPAPTTPKKPAPTTPETPPPTTSEVST--------------PTTTKEPTTIHKSPD 781

Query: 1389 GRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPT 1448
                   E TP +S +  P   +     P       P  +   KP +      KTT    
Sbjct: 782  -------ESTPELSAEPTPKALENSPKEPGVPTTKTPAAT---KPEMTTTAKDKTTERDL 831

Query: 1449 TTMQPTTTTTPLPT---------TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTT---R 1496
             T   TTT  P  T         TT  + T  TT+ T+TT + TT    TT++TTT   +
Sbjct: 832  RTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPK 891

Query: 1497 TTTTTTPTPTTPIPTCPPGTLERHD 1521
             TTT     TT I   P  T +  D
Sbjct: 892  VTTTKKTITTTEIMNKPEETAKPKD 916



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 171/869 (19%), Positives = 271/869 (31%), Gaps = 120/869 (13%)

Query: 666  PRPALSP-SRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHG 724
            PRP+L P S  S  + L          K  +   +   +   E+ +SA    S       
Sbjct: 167  PRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT--- 223

Query: 725  GSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEAS 784
             +  L PT   L+ P  K     +    T    P+ +T     S+     T  +  +  +
Sbjct: 224  SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 283

Query: 785  DGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQ 844
              +       +      +  A T    PA         +P     + P+  +    P   
Sbjct: 284  TPKEPAPTTTKSAPTTPKEPAPTTTKEPAP----TTPKEPAPTTTKEPAPTTTKSAPTTP 339

Query: 845  PSSSPQSTVPSRAHPRVPSH-SDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPIS 903
               +P  T P +  P  P   + + PK  +     E      PA    +  P++ ++P  
Sbjct: 340  KEPAP--TTPKKPAPTTPKEPAPTTPKEPTPTTPKE------PAPTTKEPAPTTPKEPAP 391

Query: 904  RGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGH 963
                    +P++ A    KEP P  PK     T  +   ++    A    +S    T+  
Sbjct: 392  T-------APKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK-- 442

Query: 964  SPKAQPGSTDRHASPARP----PAARSQQHPSVPRR---MTPGRAPQQQPPPPVATSQHH 1016
                +P  T   ++P  P    P    +  P+ P+     TP +     P  P  T+   
Sbjct: 443  ----EPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 498

Query: 1017 PGPQS--RDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDED 1074
            P P +  + A  +P +P  + T      PT+  +   ++    A +    P     ++  
Sbjct: 499  PAPTTTKKPAPTTPKEP--APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 556

Query: 1075 AQGSYDDDSTEVEAQDVRAPAHAA--RAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHA 1132
                 +   T  E      P  AA    KE A + PK     +P            +  A
Sbjct: 557  PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP------------KEPA 604

Query: 1133 ASPARPSRPGGPQSRA----RVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFF 1188
             +  + + P  P+  A    + P+   P K  P    P ++K   S + +          
Sbjct: 605  PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 664

Query: 1189 KGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPP 1248
                    + + PK P+ +TP+G          +E  P     P    LAP     P   
Sbjct: 665  APTTPKEPAPTTPKEPAPTTPKG----TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTST 720

Query: 1249 GSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFS-TTPMLSLRQRMMHARF 1307
             S   A   P    P +    +P     P P      PP     +TP  +     +H   
Sbjct: 721  TSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP 780

Query: 1308 RNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLN 1367
                    A P+             K L  S  +P G      P  TK            
Sbjct: 781  DESTPELSAEPT------------PKALENSPKEP-GVPTTKTPAATK------------ 815

Query: 1368 AEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPIL 1427
                        P       D  T  DL  TP  +     +  +       A   +K   
Sbjct: 816  ------------PEMTTTAKDKTTERDLRTTPETTTAAPKMTKE------TATTTEKTTE 857

Query: 1428 SLGGKPLVGLEVIKKTTHPPTTTMQPTT--TTTPLPTTTTPRPTTATTRRTTTTRRTTTR 1485
            S         ++   TT   +TT Q TT    T L TTT   P   TT++T TT      
Sbjct: 858  S---------KITATTTQVTSTTTQDTTPFKITTLKTTTL-APKVTTTKKTITTTE-IMN 906

Query: 1486 RPTTTVRTTTRTTTTTTPTPTTPIPTCPP 1514
            +P  T +   R T +   TP    PT  P
Sbjct: 907  KPEETAKPKDRATNSKATTPKPQKPTKAP 935



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 130/733 (17%), Positives = 246/733 (33%), Gaps = 103/733 (14%)

Query: 460  ADVEQNTEDNGKPEKPEPSSP----------------SPRAPASSQHPSVPASPQGRNAK 503
            A+V+ N ++  K +KP P  P                +    +++QH  V  SP+   AK
Sbjct: 105  AEVKDNKKNRTK-KKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAK 163

Query: 504  DLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQK 563
             +  + +  +  N    ++  L   K   ++ + T  T ++     ++   S  +TQ  +
Sbjct: 164  PI--NPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIE 221

Query: 564  RT------------LRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPG 611
            +T             +P  +   +   P  T  +   P  P+     +P  +   +P P 
Sbjct: 222  KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPK-----EPASTTPKEPTPT 276

Query: 612  APPSASASPAHHA--STQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPA 669
               SA  +P   A  +T+     P  PA     +   +   E A  +             
Sbjct: 277  TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAP 336

Query: 670  LSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRL 729
             +P   +P++  +   +      P +P   TP +   +E +  +  P+  +P     +  
Sbjct: 337  TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT--PKEPAPTTKEPAPTTPKEPAPTA- 393

Query: 730  LPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESH 789
             P +P  ++P        ++   T +  PS +T      +   S    ++    +  +S 
Sbjct: 394  -PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 452

Query: 790  GDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSP 849
                +E      +  A T    PA         KP     + P+  +  + P    +  P
Sbjct: 453  PTTPKEPSPTTTKEPAPTTPKEPAP----TTPKKPAPTTPKEPAP-TTPKEPAPTTTKKP 507

Query: 850  QSTVPSRAHPRVPSHS-DSHPKLSSGIHGDE----EDEKPLPAT-------VVNDHVPSS 897
              T P    P  P  +  + PK  +    ++      EKP P T          +  P++
Sbjct: 508  APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 567

Query: 898  SRQPI---------SRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSS---- 944
              +P          +   E    +P+  A    KEP P  PK T A T P+G   +    
Sbjct: 568  PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKET-APTTPKGTAPTTLKE 626

Query: 945  -------------LASKAQDVQQSTDAD---------TEGHSPKAQPGSTDRHASPARP- 981
                         LA        ST  D         T   +PK    +T +  +P  P 
Sbjct: 627  PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPK 686

Query: 982  ---PAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQS--RDAGRSPSQPRLSLT 1036
               P    +  P+ P++  P          P +T+   P P +    A  +P +P  + T
Sbjct: 687  GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP--APT 744

Query: 1037 QAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAH 1096
               +P PT+      ++   +  +    PT +    +++      + T    ++      
Sbjct: 745  TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 804

Query: 1097 AARAKEAAASLPK 1109
                K  AA+ P+
Sbjct: 805  VPTTKTPAATKPE 817



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 133/692 (19%), Positives = 196/692 (28%), Gaps = 97/692 (14%)

Query: 924  PIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARP-- 981
            P  +  K T    + +    +  +   + Q STD   +  S K         A    P  
Sbjct: 173  PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTS 232

Query: 982  -----PAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQS-RDAGRSPSQPRLSL 1035
                 P  +++     P   TP       P  P +T+   P P + + A  +P +P  + 
Sbjct: 233  KVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTT 292

Query: 1036 TQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPA 1095
            T++    P     + ++ +P   + +   PT                 T  E       +
Sbjct: 293  TKSAPTTPKEPAPT-TTKEPAPTTPKEPAPT-----------------TTKEPAPTTTKS 334

Query: 1096 HAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAA 1155
                 KE A + PK     +P                 +P  P  P     +   P+   
Sbjct: 335  APTTPKEPAPTTPKKPAPTTPK--------------EPAPTTPKEPTPTTPKEPAPTTKE 380

Query: 1156 PGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDA 1215
            P  + P    P + K     + ++                     P  P    P   K+ 
Sbjct: 381  PAPTTPKEPAPTAPKKPAPTTPKEP-------------------APTTPKEPAPTTTKEP 421

Query: 1216 DGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGT 1275
              +  KE        AP        K P P    S+P     PS   P +    +P    
Sbjct: 422  SPTTPKEPAPTTTKSAP-----TTTKEPAPTTTKSAPTTPKEPS---PTTTKEPAPTTPK 473

Query: 1276 HPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVL 1335
             P P  T + P       P  +  +       + P    P  P+        P    K+ 
Sbjct: 474  EPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLT 532

Query: 1336 PGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDL 1395
            P +  K         P+        +       E          P   K           
Sbjct: 533  PTTPEK----LAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPA 588

Query: 1396 EGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPP-------T 1448
              TP       P     +   P    +  P    G  P    E    T   P       T
Sbjct: 589  PTTPKEPAPTTP-----KEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 643

Query: 1449 TTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTP 1508
            TT +PT+TT   P  TTP+ T  TT +      TT + P  T    T  TT   P PTTP
Sbjct: 644  TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP--TTPKEPAPTTPKGTAPTTLKEPAPTTP 701

Query: 1509 IPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFE 1568
                P               S    P    E    +  E     P + A    +      
Sbjct: 702  KKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPE------ 755

Query: 1569 TSRPPTTTEPSTTATTPRVIPEEGAISSFPEE 1600
             + PPTT+E ST  TT     E   I   P+E
Sbjct: 756  -TPPPTTSEVSTPTTT----KEPTTIHKSPDE 782



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 123/613 (20%), Positives = 187/613 (30%), Gaps = 104/613 (16%)

Query: 1008 PPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTA 1067
            P  +T+QH+         +  + P+++  +   PRP+    S +S +     ++      
Sbjct: 143  PDTSTTQHN---------KVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVET 193

Query: 1068 LQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRS 1127
             +    + Q S D       A++ ++      AK+ A   P  + +  PT         +
Sbjct: 194  KETTTTNKQTSTDGKEKTTSAKETQS-IEKTSAKDLA---PTSKVLAKPTPKA----ETT 245

Query: 1128 QRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGF 1187
             +G A +  +   P  P+          P  + P    P + KS                
Sbjct: 246  TKGPALTTPKEPTPTTPKE---------PASTTPKEPTPTTIKS---------------- 280

Query: 1188 FKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPP 1247
                     + + PK P+ +T +         A    +      P+  +    K P P  
Sbjct: 281  ---------APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 331

Query: 1248 PGSSPRASHVPSRLPPRSAATVS---PVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMH 1304
              S+P     P+   P+  A  +   P   T   P  TT   P   +  P  +  +    
Sbjct: 332  TKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 391

Query: 1305 ARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGL 1364
               + P    P  P+        P    +  P +  +P      + P  TK         
Sbjct: 392  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK--------- 442

Query: 1365 VLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDK 1424
                           P   K           E +P  + +  P        TP   A   
Sbjct: 443  ------------EPAPTTTK----SAPTTPKEPSPTTTKEPAPT-------TPKEPAPTT 479

Query: 1425 PILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATT--RRTTTTRR- 1481
            P       P        K    PTTT +P  TT   P  TTP+ T  TT  + T TT   
Sbjct: 480  PKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK 538

Query: 1482 ---TTTRRPTTTVRTTTRTTTTTTPTPTT---PIPTCPPGTLERHDDDGNLIMSSNGIPE 1535
               TT  +P  T       TT   PTPTT   P PT P         +          P 
Sbjct: 539  LAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 598

Query: 1536 CYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRP------PTTT-EP-STTATTPRV 1587
               E    +  ET    P   A     E       +P      PTTT EP STT   P  
Sbjct: 599  TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 658

Query: 1588 IPEEGAISSFPEE 1600
               +G   + P+E
Sbjct: 659  TTPKGTAPTTPKE 671



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 153/865 (17%), Positives = 278/865 (32%), Gaps = 128/865 (14%)

Query: 339  QGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILS 398
            Q   DGK  T+  + T     T+A +      V  KPT         P+ E   K     
Sbjct: 202  QTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT---------PKAETTTK----- 247

Query: 399  YAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTS 458
              PAL      + T P +  S       P      K   T  +   P +     + PTT 
Sbjct: 248  -GPALTTPKEPTPTTPKEPASTTPKEPTPTT---IKSAPTTPKEPAPTTTK---SAPTTP 300

Query: 459  KADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGG 518
            K      T++       EP+  + + PA +   S P +P+                    
Sbjct: 301  KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK------------------EP 342

Query: 519  APRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVA 578
            AP  P+   K A     +    T +E   +   +P  P+ T  +     P      +   
Sbjct: 343  APTTPK---KPAPTTPKEPAPTTPKEPTPT---TPKEPAPTTKEPAPTTPKEPAPTAPKK 396

Query: 579  PGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPAS 638
            P  T  +   P  P+     +P  +   +P P  P   + +    A T      P+   S
Sbjct: 397  PAPTTPKEPAPTTPK-----EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 451

Query: 639  LNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPAS--- 695
                    S    +      PK    +P P  +P + +P++      +      P +   
Sbjct: 452  APTTPKEPSPTTTKEPAPTTPK----EPAPT-TPKKPAPTTPKEPAPTTPKEPAPTTTKK 506

Query: 696  PARRTPHSGA-AEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATN 754
            PA  TP   A      +A   P +L+P      +L PT P   +P +      E+   T 
Sbjct: 507  PAPTTPKEPAPTTPKETAPTTPKKLTPT--TPEKLAPTTPEKPAPTTP-----EELAPTT 559

Query: 755  SNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPAS 814
               P+ +T                E A  +   +  +  +E      +  A T    PA 
Sbjct: 560  PEEPTPTT--------------PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA- 604

Query: 815  GHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSG 874
                     P      +P   +  +G        P  T P +  P+  + + +    S+ 
Sbjct: 605  ---------PTTPKETAP---TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 652

Query: 875  IHGDEEDEKPLPATVVNDHVPSSSRQPI-SRGWEDLRRSPQRGASLHRKEPIPENPKSTG 933
                   +KP P T      P++ ++P  +   E    +P+  A    KEP P  PK   
Sbjct: 653  C------DKPAP-TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 705

Query: 934  ----ADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQ-- 987
                A T  +G  S+ + K         A T    P           +P  PP   S+  
Sbjct: 706  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVS 765

Query: 988  -----QHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPR 1042
                 + P+   +      P+    P     ++ P        ++P+  +  +T   + +
Sbjct: 766  TPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 825

Query: 1043 PTSQGRSHSSSDPYTASSRGMLPTALQNQ----------DEDAQGSYDDDSTEVEAQDVR 1092
             T++    ++ +  TA+ +    TA   +                +   D+T  +   ++
Sbjct: 826  -TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 884

Query: 1093 APAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPS 1152
                A +      ++   + +  P       D R+    A +P    +P  P    + P+
Sbjct: 885  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKD-RATNSKATTP----KPQKPTKAPKKPT 939

Query: 1153 RAAPGKSEPPSKRPLSSKSQQSVSA 1177
                 K+ P  ++P ++ + + +++
Sbjct: 940  STKKPKTMPRVRKPKTTPTPRKMTS 964


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 220/1013 (21%), Positives = 327/1013 (32%), Gaps = 131/1013 (12%)

Query: 433  FKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTE--DNGKPEKPEPSSPSPRAPASSQH 490
            F + + +  G+ P +        TT+   +E          P K    +  P  P +S++
Sbjct: 648  FPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASEN 707

Query: 491  PSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRA----KKAEELDLQST--EITGEE 544
              V  SPQ   A    L L  +I  +  +P  P        KK + +   S    +    
Sbjct: 708  CPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSP 767

Query: 545  ELGSREDSPMSPSDTQDQKRTLR----PPSRHGHSVVAPGRTAVRARMPALPRREGVDKP 600
            +    EDS    S T   K TL      PS  G SV      + + + P  P ++G   P
Sbjct: 768  KECPTEDS--GASATASSKGTLTYLADSPSPLGVSV------SPQTKRP--PTKKGSAGP 817

Query: 601  GFSLATQPRPGAPPSASASPAHHASTQG------TSHRPSLPASLNDNDLVDSDEDERAV 654
               +     P +P  AS  P +  S QG      T+H P+ P+               AV
Sbjct: 818  DTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSP-------KGAPTPSAV 870

Query: 655  GSLHPKGAFAQPRPALSPS----------------RQSPSSVLRDRSSVHPGAKPASPAR 698
              L PKG    P+   +PS                +Q+P+  +   S     A PA    
Sbjct: 871  TPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGI 930

Query: 699  RTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGG---KDGEDAPATNS 755
                S        A+ PPS    P   S +  PT P  + P  KGG      + AP   +
Sbjct: 931  PASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPA 990

Query: 756  NAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASG 815
              P       +  S   + T  +    +  G        +       AT  + +  PA+ 
Sbjct: 991  ATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAA- 1049

Query: 816  HFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVP--SRAHPRVPS-------HSD 866
               L +  P       PS       P L+ + +P +  P   +  P  PS        + 
Sbjct: 1050 -TPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAA 1108

Query: 867  SHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIP 926
            + P    G+        P                P  +G      +           P P
Sbjct: 1109 TPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPP 1168

Query: 927  ENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARS 986
            +   +T A T P  K   LA+ +     +T A T   SPK    +     +P  P A   
Sbjct: 1169 KGAPTTPAATPPSPK-GGLATPSPKGAPTTPAATP-PSPKGGLATPSPKGAPTTPAAT-- 1224

Query: 987  QQHPSVPRRMTPGRAPQQQPPPPVATSQHHPG----PQSRDAGRSPSQPRLSL------- 1035
               P  P+      +P+  P  P AT     G    P  + A   P+    SL       
Sbjct: 1225 ---PPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATP 1281

Query: 1036 TQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPA 1095
               G P P           P T+  +G  PT         +GS     T         PA
Sbjct: 1282 PHKGAPNPAVVTPPSPKGGPATSPPKG-APTPPAATPPSPKGS---PGTPPPKGAPTPPA 1337

Query: 1096 HAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSR-- 1153
                + +   +LP      +P+  G      S+ G     A PS  GGP      P R  
Sbjct: 1338 VTPPSPKGTPTLP----ATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGP 1393

Query: 1154 AAPG-KSEP--PSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSS-----SVPKWPS 1205
            A P  K +P  P+  PLS K   +     +     G     K DL        S+ K P+
Sbjct: 1394 AIPSPKGDPTSPAVIPLSPKKAPATPVTRE-----GAATPSKGDLTPPAVTPVSLKKAPA 1448

Query: 1206 SSTPRGGKDADGSL------AKEEREPAIALAPR--GGSLAPVKRPLPPPPGSSPRASHV 1257
            +S P+GG     S       A     P    AP+    S +P K P  P P  +P    V
Sbjct: 1449 TSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAV 1508

Query: 1258 ----PSRLPPRSAATVSPVAGTHPWPQYTTRA--PPGHFSTTPMLSLRQRMMHARFRNPL 1311
                P  +P   ++   P+A T       T A   P      P +++           P 
Sbjct: 1509 IPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTP- 1567

Query: 1312 SRQPARPSYRQG----------YNGRPNVEGKVLPGSNGKPNGQRIINGPQGT 1354
               PA PS ++           Y G P+ +  ++P +   P+ +     P  T
Sbjct: 1568 KEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVT 1620



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 206/937 (21%), Positives = 303/937 (32%), Gaps = 154/937 (16%)

Query: 410  SLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTT---SKADVEQNT 466
            +LTY  D+ S L   + P      K   T +   GP +    ++ P +   +    E + 
Sbjct: 786  TLTYLADSPSPLGVSVSPQT----KRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSL 841

Query: 467  EDNGKPEKPEPS-SPSPRAPASSQHPSV--PASPQGRNAKDLLLDLKNKILANGGAPRK- 522
               G  + P  + SP+P +P  +  PS   P SP+G        +     + N   P++ 
Sbjct: 842  SFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPK--ETPTPSVVNLPFPKEG 899

Query: 523  PQLRA-KKAEELDLQSTEITGEEELGSREDSPMSPSDT-QDQKRTLRPPSRHGHSVV--- 577
            P   A K+A  L + S+         + +  P SPS           PPS  G       
Sbjct: 900  PATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSP 959

Query: 578  --APGRTAVRARMP----ALPRREGVDKPGFSLATQPRPG---------------APPSA 616
              AP   A     P    A P  +G   P  +    P+ G                PPS 
Sbjct: 960  KWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSP 1019

Query: 617  SASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQS 676
              SPA     +G S  P+            S +   A   L PKGA   P   L   +  
Sbjct: 1020 KGSPAATPFPKGASTPPAATPP--------SPKGSPAATPL-PKGAPTTPAATLPSPKGG 1070

Query: 677  PSSVLRDRSSVHPGAKPASP--ARRTPHSGAAEEDSSASAPPSR---LSPPHGGSSRLLP 731
            P++     +   P A P SP     TP    A    +A+ P  +    +PPH G+    P
Sbjct: 1071 PATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGA----P 1126

Query: 732  TQPHLSSPLSKGG---KDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGES 788
            T P  + P  KGG      + AP T +  P         S      T   +GA  +   +
Sbjct: 1127 TTPAATPPSPKGGLATPPPKGAPTTPAATPP--------SPKGGLATPPPKGAPTTPAAT 1178

Query: 789  HGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSS 848
                         +    T  A P S    L    P              +G    P+++
Sbjct: 1179 PPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSP--------------KGAPTTPAAT 1224

Query: 849  PQS------TVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPI 902
            P S      T   +  P  P+ +   PK      G      P  A       P ++  P 
Sbjct: 1225 PPSPKGGLATPSPKGAPTTPAATPPSPK------GGPATPPPKGAPT-----PPAATPPS 1273

Query: 903  SRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEG 962
             +G   L   P +GA  +     P +PK   A + P+G  +  A+               
Sbjct: 1274 LKG--GLATPPHKGAP-NPAVVTPPSPKGGPATSPPKGAPTPPAATPP------------ 1318

Query: 963  HSPKAQPGSTDRHASPARPPAARSQQHPSVPR--RMTPGR-------APQQQPPPPVATS 1013
             SPK  PG+     +P  PPA         P     TP         + ++ P PP AT 
Sbjct: 1319 -SPKGSPGTPPPKGAPT-PPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATP 1376

Query: 1014 QHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDE 1073
             H  GP    A   PS  R     + +  PTS      +  P +       P   +    
Sbjct: 1377 SHKGGP----AMTPPSPKRGPAIPSPKGDPTSP-----AVIPLSPKKAPATPVTREGAAT 1427

Query: 1074 DAQGSYDDDS-TEVEAQDVRAPAHAARAKEAAASLPKHQQV------ESPTGAGAGGDHR 1126
             ++G     + T V  +  +APA +A     A    K           SP    A     
Sbjct: 1428 PSKGDLTPPAVTPVSLK--KAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVA 1485

Query: 1127 SQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRP--------LSSKSQQSVSAE 1178
            +      +PA P+  G P   A +PS      + P S+R         LS K+  +++ +
Sbjct: 1486 TSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPK 1545

Query: 1179 DDEEEDAGFFKGGKEDLL---SSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGG 1235
            +     A      K+          P  PSS           S  K    P   L P   
Sbjct: 1546 EALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAV 1605

Query: 1236 SLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPV 1272
            +    K    PP  + P     P+   P+   T  PV
Sbjct: 1606 TSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPV 1642



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 235/1070 (21%), Positives = 339/1070 (31%), Gaps = 233/1070 (21%)

Query: 591  LPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDE- 649
            +P  +G   P   ++T P     P AS      +  Q T       AS    D   S   
Sbjct: 196  VPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVL 255

Query: 650  -DERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEE 708
               +  GSL  KG  + P  ALS S QS   V   + +  P   P  P     H     +
Sbjct: 256  ISPQNPGSLSLKGPVSPPA-ALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQ 314

Query: 709  DSSASAP------PSRLSPP--------HGGSSRLLPTQPHLSSPLSKGGKDGEDAPATN 754
             S  S        PS LS P        H  +    P+Q  +  PL       E  PAT 
Sbjct: 315  SSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRN---EVVPATV 371

Query: 755  SNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARP-A 813
            +  P  +       S +SS T    G+           +       +  T+  L++ P A
Sbjct: 372  AAFPVVAPSVDKGPSTISSITCSPSGSL----------NVATSFSLSPTTSLILKSSPNA 421

Query: 814  SGHFHLLRHKPFAANGRSP--------------SRFSIGR--------GP--RLQPSSSP 849
            + H+ L+   P ++ G +P              + F +          GP   ++P+S P
Sbjct: 422  TYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTS-P 480

Query: 850  QSTVPSRAHPRVPSHSDS-------HPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPI 902
             + V +   P+ PS   +        P L      D ED K LP++V+         Q +
Sbjct: 481  AALVMAPVAPKEPSTQVATTLRIPVSPPLP-----DPEDLKNLPSSVLVKFPTQKDLQTV 535

Query: 903  SRGWEDLRRSPQRGASLHRKEPI--------PENPKS----TGADTHPQGKYSSLASKAQ 950
                E    SP +     +K+P         P+N  S    + +   P    ++LA K+ 
Sbjct: 536  PASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSL 595

Query: 951  DVQ------QSTDADTEGHSPKAQPGSTDRHASP--ARPPAARSQQHPSV---------P 993
                      S+     G +  A    TD +A P  A P    S   P+V         P
Sbjct: 596  GEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADP 655

Query: 994  RRMTP---------------------GRAPQQQPP--------PPVATSQHH----PGPQ 1020
              + P                       AP+  P         P V T+  +    P PQ
Sbjct: 656  AGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQ 715

Query: 1021 SRDAGRSP---------SQPRLSLTQAGRPRPTSQ--GRSHSSSDPYTASSRGMLPTALQ 1069
            +  A  +          S P  SL  AG P  T +  G SH+S+    ASS    PT   
Sbjct: 716  NTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPT--- 772

Query: 1070 NQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQR 1129
             +D  A  +     T     D  +P   + +          Q    PT  G+ G   +  
Sbjct: 773  -EDSGASATASSKGTLTYLADSPSPLGVSVSP---------QTKRPPTKKGSAGPD-TPI 821

Query: 1130 GHAASPARP-----------SRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAE 1178
            G+ +SP  P           S  G   S A   S   P     P+   ++  S + V+  
Sbjct: 822  GNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLP 881

Query: 1179 DDEEEDAG-----FFKGGKE----------DLLSSSVPKWPSSSTPRGGKDADGSLAKEE 1223
              E          F K G             + SSS  K  ++  P+G   +        
Sbjct: 882  PKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPT 941

Query: 1224 REPAIALAPRGGSLAPVKRPLPPPPGSSPRASHV-PSRLPPRSAATVSPVAGTHPWPQYT 1282
               A   +P+GG   P  +  P PP ++P +    P+   P+ A T  P A T P P+  
Sbjct: 942  PPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPT--PPAATPPSPKGG 999

Query: 1283 TRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPA--RPSYRQGYNGRPNVEGKVLPGSNG 1340
               P    + TP                    PA   PS +      P  +G   P +  
Sbjct: 1000 PATPSPKGAPTP--------------------PAVTPPSPKGSPAATPFPKGASTPPAAT 1039

Query: 1341 KPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPV 1400
             P+       P+G+     L +G         L    G P              L+G P 
Sbjct: 1040 PPS-------PKGSPAATPLPKGAPTTPAAT-LPSPKGGP----------ATPSLKGAPT 1081

Query: 1401 VSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPL 1460
              P   P   +G   TP       P  +    P  GL       H    T    T  +P 
Sbjct: 1082 -PPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLAT---PPHKGAPTTPAATPPSPK 1137

Query: 1461 PTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIP 1510
                TP P  A      TT   T   P   + T       TTP  T P P
Sbjct: 1138 GGLATPPPKGA-----PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSP 1182



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 182/883 (20%), Positives = 279/883 (31%), Gaps = 163/883 (18%)

Query: 470  GKPEKPEPSSPSPR-APASSQHP--------SVPASPQGRNA-----KDLLLDLKNKILA 515
            G P  P  + PSP+ +PA++  P        + P SP+G  A     K         + +
Sbjct: 1007 GAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066

Query: 516  NGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKR----------- 564
              G P  P L+           +   G     S + +PM P+ T    +           
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSP-KGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGA 1125

Query: 565  ----TLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASA-- 618
                   PPS  G     P + A        P  +G       LAT P  GAP + +A  
Sbjct: 1126 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG------GLATPPPKGAPTTPAATP 1179

Query: 619  -SPAHHASTQGTSHRPSLPASLNDNDL-------VDSDEDERAVGSLHPKGAFAQPRPAL 670
             SP    +T      P+ PA+   +                 A     PKG  A P P  
Sbjct: 1180 PSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKG 1239

Query: 671  SPSRQS--PSSVLRDRSSVHPGAKPASPARRTPH--SGAAEEDSSASAPPSRLSPPH--G 724
            +P+  +  P S     ++  P   P  PA   P    G A      +  P+ ++PP   G
Sbjct: 1240 APTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKG 1299

Query: 725  GSSRLLPT---QPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGA 781
            G +   P     P  ++P S  G  G   P      P+ +  S   +  L + T  S+G 
Sbjct: 1300 GPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGG 1359

Query: 782  EASDGESHGDGDREDGGRQAEATAQTL------------RARPASGHFHLLRHKPFAAN- 828
              +     G              A T             +  P S     L  K   A  
Sbjct: 1360 PTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATP 1419

Query: 829  -----GRSPSR----------FSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSS 873
                   +PS+           S+ + P         +T  S+  P +P+ +   PK   
Sbjct: 1420 VTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPK--- 1476

Query: 874  GIHGDEEDEKPLPATVVNDHVPSSS-RQPISRGWEDLRR----SPQR--GASLHRKEPIP 926
                    E P P  V     P  +   P   G   L      SP+        R++PI 
Sbjct: 1477 --------EPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIA 1528

Query: 927  ENP----KSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPP 982
                   K T A   P+      A      +++    T   +P A P S +  + PA  P
Sbjct: 1529 PTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAP-ATPSSKEASSPPAVTP 1587

Query: 983  A----ARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQA 1038
            +    A S +   +P  +T     +   PP V       GP +     +P+ P ++    
Sbjct: 1588 STYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVT---- 1643

Query: 1039 GRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAA 1098
                P+S   S +S    T      +P A               S  + A+         
Sbjct: 1644 ----PSSLKDSPTSPASVTCKMGATVPQA---------------SKGLPAKKGPTALKEV 1684

Query: 1099 RAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGK 1158
                A  S P    + +PT  G     ++++  A SP     P  P   A+  S+     
Sbjct: 1685 LVAPAPESTP---IITAPTRKGP----QTKKSSATSP-----PICPDPSAKNGSKGPLST 1732

Query: 1159 SEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGS 1218
              P    P+   S ++   +D      G              P    +STP      +  
Sbjct: 1733 VAPAPLLPVQKDSSKTAKGKDASHSPKG-----------PLAPPESKASTPLTAAAFEKV 1781

Query: 1219 LAKEEREPAIALAPRGGSLAPVKRPLPPPPGSS--PRASHVPS 1259
            L K E   +++ AP      PV  PL P P  +  P+   +PS
Sbjct: 1782 LPKPE-SASVSAAPS----PPVSLPLAPSPVPTLPPKQQFLPS 1819



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 111/507 (21%), Positives = 176/507 (34%), Gaps = 72/507 (14%)

Query: 470  GKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKK 529
            G P  P  + PSP+ P + +  +  +SP+   A            A  GAP  P +    
Sbjct: 1463 GDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATP----------APMGAPTLPAVIPSS 1512

Query: 530  AEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRA--R 587
             +E+    +         SR D P++P+ T   K+T  P +      + P    V +  +
Sbjct: 1513 PKEVPATPS---------SRRD-PIAPTATLLSKKT--PATLAPKEALIPPAMTVPSPKK 1560

Query: 588  MPALPR-REGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVD 646
             PA+P  +E    P    A+ P    P +   +P+        +     P        V 
Sbjct: 1561 TPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVT 1620

Query: 647  SDEDERAVGSLHPKGAFAQPR---PALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHS 703
                E+   +  PKG    P     +L  S  SP+SV     +  P A    PA++ P  
Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGP-- 1678

Query: 704  GAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTM 763
             A +E   A AP S                P +++P  KG       P T  ++ +   +
Sbjct: 1679 TALKEVLVAPAPES---------------TPIITAPTRKG-------PQTKKSSATSPPI 1716

Query: 764  SSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHK 823
                S+   S+  +S  A A       D  +   G+ A  + +   A P S     L   
Sbjct: 1717 CPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAA 1776

Query: 824  PFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEK 883
             F      P   S+   P   P S P +  P    P       S P L       E   K
Sbjct: 1777 AFEKVLPKPESASVSAAPS-PPVSLPLAPSPVPTLPPKQQFLPSSPGLVL-----ESPSK 1830

Query: 884  PLPATVVNDHVPSSSRQPISRGWED----LRRSPQRGASL-----HRKEPIPENPKSTGA 934
            PL     ++ +P    +PIS G       +     + A +       K+P+ +N K +G 
Sbjct: 1831 PLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGT 1890

Query: 935  DTHPQGKYSSLASKAQDVQQSTDADTE 961
            ++        L     + Q ST A T+
Sbjct: 1891 ESDSDESVPEL-----EEQDSTQATTQ 1912


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 192/854 (22%), Positives = 310/854 (36%), Gaps = 142/854 (16%)

Query: 456  TTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILA 515
            T+S +D    T+  GKP   +P+     + ++ + P+  A+P      D+   +K   L 
Sbjct: 203  TSSSSD---ETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258

Query: 516  NGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHS 575
                 +KP+  ++ +EE     +E   E   G+R  S +  S+   Q R    P++    
Sbjct: 259  PAKRAKKPEEESESSEE----GSESEEEAPAGTR--SQVKASEKILQVRAASAPAKG--- 309

Query: 576  VVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSL 635
               PG+ A     PA P + G      ++A+Q + G P   S S +  +S          
Sbjct: 310  --TPGKGAT----PAPPGKAG------AVASQTKAGKPEEDSESSSEESS---------- 347

Query: 636  PASLNDNDLVDSDEDERAVGSL---HPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAK 692
                      DS+E+  A  +L      G  +Q   A +P+++SP            GA 
Sbjct: 348  ----------DSEEETPAAKALLQAKASGKTSQVGAASAPAKESP----------RKGAA 387

Query: 693  PASPARRTP-----HSGAAEEDSSASAPPS---RLSPPHGGSSRLLPTQPHLSSPLSKGG 744
            PA P +  P      +G  EEDS +S+  S     +P     S   P     S+P  +  
Sbjct: 388  PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447

Query: 745  KDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEAT 804
            + G  AP     AP R T  ++         QV  G +  D  S    +  D  R+A A 
Sbjct: 448  RKGA-AP-----APPRKTGPAA--------AQVQVGKQEED--SRSSSEESDSDREALAA 491

Query: 805  AQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSH 864
                + +P      +   KP +  G  P    +G+G    P        PS    +    
Sbjct: 492  MNAAQVKPLGKSPQV---KPASTMGMGP----LGKGAGPVPPGKVGPATPSAQVGKWEED 544

Query: 865  SDSHPKLSSGIHGDEEDEKPLPA------TVVNDHVPSSSRQPISRGWEDLRRSPQRGAS 918
            S+S  + SS     E      PA       ++     SS  +   +    +    +    
Sbjct: 545  SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 604

Query: 919  LHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASP 978
            +   E   E+  S  ++  P    ++ A  A  + Q+          KA P  T+  AS 
Sbjct: 605  MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT----------KACPKKTNTTASA 654

Query: 979  ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPR---LSL 1035
               P     Q    PR+     +P     P VA     P   S  +  S S+     L++
Sbjct: 655  KVAPVRVGTQ---APRKAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAV 710

Query: 1036 TQAGRPRPTSQG-RSHSSSDPYTAS-SRGMLP-----TALQNQDEDAQGSYDDDSTEVEA 1088
            T  G+ +   +G +  ++S P   S  +G  P     T        A+   D +S+E E+
Sbjct: 711  T-VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769

Query: 1089 QDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRA 1148
                A A  A+ K    S+ K Q   +P  A A           ++    S PG   + A
Sbjct: 770  DSEEAAASPAQVK---TSVKKTQAKANPAAARA----------PSAKGTISAPGKVVTAA 816

Query: 1149 RVPSRAAPGKSEPPSKRPLSS----KSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWP 1204
                + +P K +PP + P +S    +   SV +       A   + G E+   SS  +  
Sbjct: 817  AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE-- 874

Query: 1205 SSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPG-SSPRASHVPSRLPP 1263
            S S       A    + +  +   ALAP   S  P K   P PPG + P A+    +   
Sbjct: 875  SDSEEEAETLAQVKPSGKTHQIRAALAPAKES--PRKGAAPTPPGKTGPSAAQAGKQDDS 932

Query: 1264 RSAATVSPVAGTHP 1277
             S++  S   G  P
Sbjct: 933  GSSSEESDSDGEAP 946



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 175/854 (20%), Positives = 290/854 (33%), Gaps = 142/854 (16%)

Query: 471  KPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKA 530
            + +KPE  S S    + S+  +   +     A + +L ++       G P K    A   
Sbjct: 262  RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321

Query: 531  EELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPA 590
            +   + S    G+ E    EDS  S  ++ D +    P ++      A G+T+ +    +
Sbjct: 322  KAGAVASQTKAGKPE----EDSESSSEESSDSEEET-PAAKALLQAKASGKTS-QVGAAS 375

Query: 591  LPRREGVDKPGFSLATQPRPGAPPS--ASASPAHHASTQGTSHRPSLPASLNDNDLVDSD 648
             P +E            PR GA P+      PA   +  G     S  +S       +SD
Sbjct: 376  APAKES-----------PRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS------EESD 418

Query: 649  EDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHS----- 703
             +E A     P G   Q R A +P+++SP            GA PA P +  P +     
Sbjct: 419  SEEEAPAQAKPSGKAPQVRAASAPAKESP----------RKGAAPAPPRKTGPAAAQVQV 468

Query: 704  GAAEEDSSASAPPSRLS------------PPHGGSSRLLPTQPHLSSPLSKGG---KDGE 748
            G  EEDS +S+  S                P G S ++ P       PL KG      G+
Sbjct: 469  GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528

Query: 749  DAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGG-RQAEATAQT 807
              PAT S                    QV +  E S+  S    D  DG    A A AQ 
Sbjct: 529  VGPATPS-------------------AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ- 568

Query: 808  LRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHP---RVPSH 864
                                        S+G   + +P+SSP    P +A P   +V + 
Sbjct: 569  --------------------------EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602

Query: 865  SDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEP 924
                   SS    D  D +  PA +       + + P ++     + +    A +     
Sbjct: 603  KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPK-KTNTTASAKVAPVRV 661

Query: 925  IPENPKSTGADTHPQGKYSSLAS----KAQDVQQSTDADTE----------GHSPKAQPG 970
              + P+  G  T P G   ++A      A+D   S ++D+E          G +     G
Sbjct: 662  GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721

Query: 971  STDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQ 1030
               + AS     +      P +P +  P    Q +      +        S +A  SP+Q
Sbjct: 722  LQVKAASVPVKGSLGQGTAPVLPGKTGP-TVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 1031 PRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQD 1090
             + S+ +       +  R+ S+    +A  + +   A   Q   ++      + +     
Sbjct: 781  VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840

Query: 1091 VRAPAHAARAKEAAASLPKHQQ-VESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRAR 1149
             R PA      +A A+  + Q   E  +G+        +     +  +PS        A 
Sbjct: 841  ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900

Query: 1150 VPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTP 1209
             P++ +P K   P+    +  S    +A+  +++D+G          SSS       S  
Sbjct: 901  APAKESPRKGAAPTPPGKTGPS----AAQAGKQDDSG----------SSS-----EESDS 941

Query: 1210 RGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATV 1269
             G   A  + A+  + P I + P      P   P      S+PR +   S    RS+++ 
Sbjct: 942  DGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARA-SESTARSSSSE 1000

Query: 1270 SPVAGTHPWPQYTT 1283
            S      P  Q  T
Sbjct: 1001 SEDEDVIPATQCLT 1014



 Score = 68.6 bits (166), Expect = 6e-11
 Identities = 162/755 (21%), Positives = 276/755 (36%), Gaps = 109/755 (14%)

Query: 513  ILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKR--TLRPPS 570
            +L     P   Q++A+K E+ +    E   EE   S      S   TQ +      R PS
Sbjct: 742  VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 801

Query: 571  RHGHSVVAPGRTAVRA-----RMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
              G ++ APG+    A     R P+  +   V  P  S      P + PS   + A  A 
Sbjct: 802  AKG-TISAPGKVVTAAAQAKQRSPSKVKPP-VRNPQNSTVLARGPASVPSVGKAVATAAQ 859

Query: 626  TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRS 685
             Q      S     +  +  DS+E+   +  + P G   Q R AL+P+++SP        
Sbjct: 860  AQTGPEEDSG----SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP-------- 907

Query: 686  SVHPGAKPASPARRTPHSG-AAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL---- 740
                GA P  P +  P +  A ++D S S+  S  S   G +   + +   +  PL    
Sbjct: 908  --RKGAAPTPPGKTGPSAAQAGKQDDSGSS--SEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 741  ---SKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDG 797
               S  G     A A  ++ P ++  S S +   SS ++  +   A+   +        G
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT-------PG 1016

Query: 798  GRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGR---GPRLQ--------PS 846
             R    T  T   R A            A++ +  SR S G+   GP  Q        P+
Sbjct: 1017 IRTNVVTMPTAHPRIAP-----KASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPA 1071

Query: 847  SSPQST-VPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRG 905
            +SPQST V ++   ++       PKL        E ++   A   +D    SS    S G
Sbjct: 1072 TSPQSTSVQAKGTNKL-----RKPKL-------PEVQQATKAPESSDDSEDSSDS--SSG 1117

Query: 906  WEDLRRSPQRGASLHR-KEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHS 964
             E+    PQ   S H    P P   ++   +T  +     + + +Q +           S
Sbjct: 1118 SEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLL----------S 1167

Query: 965  PKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAP--QQQPPPPVATSQHHP--GPQ 1020
                PG T  + S A     +    PSV   +     P  +Q+  P  A     P  G +
Sbjct: 1168 GYMTPGLTPAN-SQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGK 1226

Query: 1021 SRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSS-----DPY---TASSRGMLPTALQNQD 1072
               +G +P + R     AG P+ ++     + +      P+    A  +  +   L    
Sbjct: 1227 EAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELL 1286

Query: 1073 EDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHA 1132
            E  +    D + E   +   +        + AA  P+ ++ +   GAG GG+       +
Sbjct: 1287 EQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKK-KKKLGAGEGGE------AS 1339

Query: 1133 ASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGK 1192
             SP + S     +++     +A+    E   K  L S+  +    E++ ++  G  +GG 
Sbjct: 1340 VSPEKTSTTSKGKAKR---DKASGDVKEKKGKGSLGSQGAKD-EPEEELQKGMGTVEGGD 1395

Query: 1193 EDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPA 1227
            +   S+   K     + +  KD +    K++ + A
Sbjct: 1396 Q---SNPKSKKEKKKSDKRKKDKEKKEKKKKAKKA 1427



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 127/673 (18%), Positives = 223/673 (33%), Gaps = 128/673 (19%)

Query: 910  RRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQP 969
            +R  +  A+L  K+    +P ST   +  + +  +  +KA     ST++   G    +  
Sbjct: 62   KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 970  GSTDRHASPARPPAARSQQHPSVPR---RMTPGRAPQQQPPPPVATSQHHPGPQSRDAGR 1026
                +  +        S  HP+  +    +  G++P++   P   T+      ++ + G 
Sbjct: 122  KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS---ETEEEGS 178

Query: 1027 SPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEV 1086
             P+        A +P   S G++ SSS+  ++SS                     D T+V
Sbjct: 179  VPA-----FGAAAKPGMVSAGQADSSSEDTSSSS---------------------DETDV 212

Query: 1087 EAQDVRAPAHAARAKEAAASLPKHQQVESPTGAG------AGG-----------DHRSQR 1129
            E +    PA    +  +    P  +   +P   G       GG           +  S+ 
Sbjct: 213  EGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESES 272

Query: 1130 GHAASPARPSRPGGPQSR------------ARVPSRAAPGKS---EPPSKRPLSSKSQQS 1174
                S +    P G +S+            A  P++  PGK     PP K    +   ++
Sbjct: 273  SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332

Query: 1175 VSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRG 1234
               E+D E  +      +E+  ++       +S       A  + AKE      A AP G
Sbjct: 333  GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392

Query: 1235 GSLAPVKR------------------------PLPPPPGSSP--RASHVPSRLPPRSAAT 1268
             +   V +                            P G +P  RA+  P++  PR  A 
Sbjct: 393  KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 452

Query: 1269 VSPVAGTHP---WPQYTTRAPPGHFSTTPMLSLRQRM--MHARFRNPLSRQP-ARPSYRQ 1322
             +P   T P     Q   +      S+    S R+ +  M+A    PL + P  +P+   
Sbjct: 453  PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM 512

Query: 1323 GY-----NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSH 1377
            G         P   GKV P +     G+   +    ++   D   G V  A     + S 
Sbjct: 513  GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572

Query: 1378 GNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGL 1437
            GN L+ K                  P   P  G  +   P+A      +     KP+   
Sbjct: 573  GNILQAK------------------PTSSPAKGPPQKAGPVA------VQVKAEKPMDNS 608

Query: 1438 EVIKKTTHPPTTTMQPT--TTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTT 1495
            E  ++++    +   P   T     P    P+ T A  ++T TT            +   
Sbjct: 609  ESSEESSDSADSEEAPAAMTAAQAKPALKIPQ-TKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 1496 RTTTTTTPTPTTP 1508
            +  T T+P  ++P
Sbjct: 668  KAGTATSPAGSSP 680


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
            [Homo sapiens]
          Length = 1488

 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 192/854 (22%), Positives = 310/854 (36%), Gaps = 142/854 (16%)

Query: 456  TTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILA 515
            T+S +D    T+  GKP   +P+     + ++ + P+  A+P      D+   +K   L 
Sbjct: 203  TSSSSD---ETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258

Query: 516  NGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHS 575
                 +KP+  ++ +EE     +E   E   G+R  S +  S+   Q R    P++    
Sbjct: 259  PAKRAKKPEEESESSEE----GSESEEEAPAGTR--SQVKASEKILQVRAASAPAKG--- 309

Query: 576  VVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSL 635
               PG+ A     PA P + G      ++A+Q + G P   S S +  +S          
Sbjct: 310  --TPGKGAT----PAPPGKAG------AVASQTKAGKPEEDSESSSEESS---------- 347

Query: 636  PASLNDNDLVDSDEDERAVGSL---HPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAK 692
                      DS+E+  A  +L      G  +Q   A +P+++SP            GA 
Sbjct: 348  ----------DSEEETPAAKALLQAKASGKTSQVGAASAPAKESP----------RKGAA 387

Query: 693  PASPARRTP-----HSGAAEEDSSASAPPS---RLSPPHGGSSRLLPTQPHLSSPLSKGG 744
            PA P +  P      +G  EEDS +S+  S     +P     S   P     S+P  +  
Sbjct: 388  PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447

Query: 745  KDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEAT 804
            + G  AP     AP R T  ++         QV  G +  D  S    +  D  R+A A 
Sbjct: 448  RKGA-AP-----APPRKTGPAA--------AQVQVGKQEED--SRSSSEESDSDREALAA 491

Query: 805  AQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSH 864
                + +P      +   KP +  G  P    +G+G    P        PS    +    
Sbjct: 492  MNAAQVKPLGKSPQV---KPASTMGMGP----LGKGAGPVPPGKVGPATPSAQVGKWEED 544

Query: 865  SDSHPKLSSGIHGDEEDEKPLPA------TVVNDHVPSSSRQPISRGWEDLRRSPQRGAS 918
            S+S  + SS     E      PA       ++     SS  +   +    +    +    
Sbjct: 545  SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 604

Query: 919  LHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASP 978
            +   E   E+  S  ++  P    ++ A  A  + Q+          KA P  T+  AS 
Sbjct: 605  MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT----------KACPKKTNTTASA 654

Query: 979  ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPR---LSL 1035
               P     Q    PR+     +P     P VA     P   S  +  S S+     L++
Sbjct: 655  KVAPVRVGTQ---APRKAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAV 710

Query: 1036 TQAGRPRPTSQG-RSHSSSDPYTAS-SRGMLP-----TALQNQDEDAQGSYDDDSTEVEA 1088
            T  G+ +   +G +  ++S P   S  +G  P     T        A+   D +S+E E+
Sbjct: 711  T-VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769

Query: 1089 QDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRA 1148
                A A  A+ K    S+ K Q   +P  A A           ++    S PG   + A
Sbjct: 770  DSEEAAASPAQVK---TSVKKTQAKANPAAARA----------PSAKGTISAPGKVVTAA 816

Query: 1149 RVPSRAAPGKSEPPSKRPLSS----KSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWP 1204
                + +P K +PP + P +S    +   SV +       A   + G E+   SS  +  
Sbjct: 817  AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE-- 874

Query: 1205 SSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPG-SSPRASHVPSRLPP 1263
            S S       A    + +  +   ALAP   S  P K   P PPG + P A+    +   
Sbjct: 875  SDSEEEAETLAQVKPSGKTHQIRAALAPAKES--PRKGAAPTPPGKTGPSAAQAGKQDDS 932

Query: 1264 RSAATVSPVAGTHP 1277
             S++  S   G  P
Sbjct: 933  GSSSEESDSDGEAP 946



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 175/854 (20%), Positives = 290/854 (33%), Gaps = 142/854 (16%)

Query: 471  KPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKA 530
            + +KPE  S S    + S+  +   +     A + +L ++       G P K    A   
Sbjct: 262  RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321

Query: 531  EELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPA 590
            +   + S    G+ E    EDS  S  ++ D +    P ++      A G+T+ +    +
Sbjct: 322  KAGAVASQTKAGKPE----EDSESSSEESSDSEEET-PAAKALLQAKASGKTS-QVGAAS 375

Query: 591  LPRREGVDKPGFSLATQPRPGAPPS--ASASPAHHASTQGTSHRPSLPASLNDNDLVDSD 648
             P +E            PR GA P+      PA   +  G     S  +S       +SD
Sbjct: 376  APAKES-----------PRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS------EESD 418

Query: 649  EDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHS----- 703
             +E A     P G   Q R A +P+++SP            GA PA P +  P +     
Sbjct: 419  SEEEAPAQAKPSGKAPQVRAASAPAKESP----------RKGAAPAPPRKTGPAAAQVQV 468

Query: 704  GAAEEDSSASAPPSRLS------------PPHGGSSRLLPTQPHLSSPLSKGG---KDGE 748
            G  EEDS +S+  S                P G S ++ P       PL KG      G+
Sbjct: 469  GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528

Query: 749  DAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGG-RQAEATAQT 807
              PAT S                    QV +  E S+  S    D  DG    A A AQ 
Sbjct: 529  VGPATPS-------------------AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ- 568

Query: 808  LRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHP---RVPSH 864
                                        S+G   + +P+SSP    P +A P   +V + 
Sbjct: 569  --------------------------EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602

Query: 865  SDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEP 924
                   SS    D  D +  PA +       + + P ++     + +    A +     
Sbjct: 603  KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPK-KTNTTASAKVAPVRV 661

Query: 925  IPENPKSTGADTHPQGKYSSLAS----KAQDVQQSTDADTE----------GHSPKAQPG 970
              + P+  G  T P G   ++A      A+D   S ++D+E          G +     G
Sbjct: 662  GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721

Query: 971  STDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQ 1030
               + AS     +      P +P +  P    Q +      +        S +A  SP+Q
Sbjct: 722  LQVKAASVPVKGSLGQGTAPVLPGKTGP-TVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 1031 PRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQD 1090
             + S+ +       +  R+ S+    +A  + +   A   Q   ++      + +     
Sbjct: 781  VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840

Query: 1091 VRAPAHAARAKEAAASLPKHQQ-VESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRAR 1149
             R PA      +A A+  + Q   E  +G+        +     +  +PS        A 
Sbjct: 841  ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900

Query: 1150 VPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTP 1209
             P++ +P K   P+    +  S    +A+  +++D+G          SSS       S  
Sbjct: 901  APAKESPRKGAAPTPPGKTGPS----AAQAGKQDDSG----------SSS-----EESDS 941

Query: 1210 RGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATV 1269
             G   A  + A+  + P I + P      P   P      S+PR +   S    RS+++ 
Sbjct: 942  DGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARA-SESTARSSSSE 1000

Query: 1270 SPVAGTHPWPQYTT 1283
            S      P  Q  T
Sbjct: 1001 SEDEDVIPATQCLT 1014



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 163/779 (20%), Positives = 275/779 (35%), Gaps = 120/779 (15%)

Query: 513  ILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKR--TLRPPS 570
            +L     P   Q++A+K E+ +    E   EE   S      S   TQ +      R PS
Sbjct: 742  VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 801

Query: 571  RHGHSVVAPGRTAVRA-----RMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
              G ++ APG+    A     R P+  +   V  P  S      P + PS   + A  A 
Sbjct: 802  AKG-TISAPGKVVTAAAQAKQRSPSKVKPP-VRNPQNSTVLARGPASVPSVGKAVATAAQ 859

Query: 626  TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRS 685
             Q      S     +  +  DS+E+   +  + P G   Q R AL+P+++SP        
Sbjct: 860  AQTGPEEDSG----SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP-------- 907

Query: 686  SVHPGAKPASPARRTPHSG-AAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL---- 740
                GA P  P +  P +  A ++D S S+  S  S   G +   + +   +  PL    
Sbjct: 908  --RKGAAPTPPGKTGPSAAQAGKQDDSGSS--SEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 741  ---SKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQ--------------------- 776
               S  G     A A  ++ P ++  S S +   SS ++                     
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 777  -------VSEGAEASDGESHGDGDR-EDGGRQAEATAQTLRARPASGHFHLLRHKPFAAN 828
                   ++  A  +   S  +  R  DG +Q     Q  +  PAS        K  A  
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLA-- 1081

Query: 829  GRSPSRFSIGRGP--RLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKP-L 885
                 + S  + P  R QPSS   S V +     +P+ S     + +   G  +  KP L
Sbjct: 1082 ----QKASEAQPPVARTQPSSGVDSAVGT-----LPATSPQSTSVQA--KGTNKLRKPKL 1130

Query: 886  PATVVNDHVPSSS-----RQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQG 940
            P        P SS         S G E+    PQ   S H   P P   ++   +T  + 
Sbjct: 1131 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES 1190

Query: 941  KYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGR 1000
                + + +Q +           S    PG T  + S A     +    PSV   +    
Sbjct: 1191 SEDDVVAPSQSLL----------SGYMTPGLTPAN-SQASKATPKLDSSPSVSSTLAAKD 1239

Query: 1001 AP--QQQPPPPVATSQHHP--GPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSS--- 1053
             P  +Q+  P  A     P  G +   +G +P + R     AG P+ ++     + +   
Sbjct: 1240 DPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCL 1299

Query: 1054 --DPY---TASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLP 1108
               P+    A  +  +   L    E  +    D + E   +   +        + AA  P
Sbjct: 1300 LGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTP 1359

Query: 1109 KHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLS 1168
            + ++ +   GAG GG+       + SP + S     +++     +A+    E   K  L 
Sbjct: 1360 RSKK-KKKLGAGEGGE------ASVSPEKTSTTSKGKAKR---DKASGDVKEKKGKGSLG 1409

Query: 1169 SKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPA 1227
            S+  +    E++ ++  G  +GG +   S+   K     + +  KD +    K++ + A
Sbjct: 1410 SQGAKD-EPEEELQKGMGTVEGGDQ---SNPKSKKEKKKSDKRKKDKEKKEKKKKAKKA 1464



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 127/673 (18%), Positives = 223/673 (33%), Gaps = 128/673 (19%)

Query: 910  RRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQP 969
            +R  +  A+L  K+    +P ST   +  + +  +  +KA     ST++   G    +  
Sbjct: 62   KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 970  GSTDRHASPARPPAARSQQHPSVPR---RMTPGRAPQQQPPPPVATSQHHPGPQSRDAGR 1026
                +  +        S  HP+  +    +  G++P++   P   T+      ++ + G 
Sbjct: 122  KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS---ETEEEGS 178

Query: 1027 SPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEV 1086
             P+        A +P   S G++ SSS+  ++SS                     D T+V
Sbjct: 179  VPA-----FGAAAKPGMVSAGQADSSSEDTSSSS---------------------DETDV 212

Query: 1087 EAQDVRAPAHAARAKEAAASLPKHQQVESPTGAG------AGG-----------DHRSQR 1129
            E +    PA    +  +    P  +   +P   G       GG           +  S+ 
Sbjct: 213  EGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESES 272

Query: 1130 GHAASPARPSRPGGPQSR------------ARVPSRAAPGKS---EPPSKRPLSSKSQQS 1174
                S +    P G +S+            A  P++  PGK     PP K    +   ++
Sbjct: 273  SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332

Query: 1175 VSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRG 1234
               E+D E  +      +E+  ++       +S       A  + AKE      A AP G
Sbjct: 333  GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392

Query: 1235 GSLAPVKR------------------------PLPPPPGSSP--RASHVPSRLPPRSAAT 1268
             +   V +                            P G +P  RA+  P++  PR  A 
Sbjct: 393  KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 452

Query: 1269 VSPVAGTHP---WPQYTTRAPPGHFSTTPMLSLRQRM--MHARFRNPLSRQP-ARPSYRQ 1322
             +P   T P     Q   +      S+    S R+ +  M+A    PL + P  +P+   
Sbjct: 453  PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM 512

Query: 1323 GY-----NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSH 1377
            G         P   GKV P +     G+   +    ++   D   G V  A     + S 
Sbjct: 513  GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572

Query: 1378 GNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGL 1437
            GN L+ K                  P   P  G  +   P+A      +     KP+   
Sbjct: 573  GNILQAK------------------PTSSPAKGPPQKAGPVA------VQVKAEKPMDNS 608

Query: 1438 EVIKKTTHPPTTTMQPT--TTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTT 1495
            E  ++++    +   P   T     P    P+ T A  ++T TT            +   
Sbjct: 609  ESSEESSDSADSEEAPAAMTAAQAKPALKIPQ-TKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 1496 RTTTTTTPTPTTP 1508
            +  T T+P  ++P
Sbjct: 668  KAGTATSPAGSSP 680


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
            sapiens]
          Length = 1450

 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 192/854 (22%), Positives = 310/854 (36%), Gaps = 142/854 (16%)

Query: 456  TTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILA 515
            T+S +D    T+  GKP   +P+     + ++ + P+  A+P      D+   +K   L 
Sbjct: 203  TSSSSD---ETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258

Query: 516  NGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHS 575
                 +KP+  ++ +EE     +E   E   G+R  S +  S+   Q R    P++    
Sbjct: 259  PAKRAKKPEEESESSEE----GSESEEEAPAGTR--SQVKASEKILQVRAASAPAKG--- 309

Query: 576  VVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSL 635
               PG+ A     PA P + G      ++A+Q + G P   S S +  +S          
Sbjct: 310  --TPGKGAT----PAPPGKAG------AVASQTKAGKPEEDSESSSEESS---------- 347

Query: 636  PASLNDNDLVDSDEDERAVGSL---HPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAK 692
                      DS+E+  A  +L      G  +Q   A +P+++SP            GA 
Sbjct: 348  ----------DSEEETPAAKALLQAKASGKTSQVGAASAPAKESP----------RKGAA 387

Query: 693  PASPARRTP-----HSGAAEEDSSASAPPS---RLSPPHGGSSRLLPTQPHLSSPLSKGG 744
            PA P +  P      +G  EEDS +S+  S     +P     S   P     S+P  +  
Sbjct: 388  PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447

Query: 745  KDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEAT 804
            + G  AP     AP R T  ++         QV  G +  D  S    +  D  R+A A 
Sbjct: 448  RKGA-AP-----APPRKTGPAA--------AQVQVGKQEED--SRSSSEESDSDREALAA 491

Query: 805  AQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSH 864
                + +P      +   KP +  G  P    +G+G    P        PS    +    
Sbjct: 492  MNAAQVKPLGKSPQV---KPASTMGMGP----LGKGAGPVPPGKVGPATPSAQVGKWEED 544

Query: 865  SDSHPKLSSGIHGDEEDEKPLPA------TVVNDHVPSSSRQPISRGWEDLRRSPQRGAS 918
            S+S  + SS     E      PA       ++     SS  +   +    +    +    
Sbjct: 545  SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 604

Query: 919  LHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASP 978
            +   E   E+  S  ++  P    ++ A  A  + Q+          KA P  T+  AS 
Sbjct: 605  MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT----------KACPKKTNTTASA 654

Query: 979  ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPR---LSL 1035
               P     Q    PR+     +P     P VA     P   S  +  S S+     L++
Sbjct: 655  KVAPVRVGTQ---APRKAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAV 710

Query: 1036 TQAGRPRPTSQG-RSHSSSDPYTAS-SRGMLP-----TALQNQDEDAQGSYDDDSTEVEA 1088
            T  G+ +   +G +  ++S P   S  +G  P     T        A+   D +S+E E+
Sbjct: 711  T-VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769

Query: 1089 QDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRA 1148
                A A  A+ K    S+ K Q   +P  A A           ++    S PG   + A
Sbjct: 770  DSEEAAASPAQVK---TSVKKTQAKANPAAARA----------PSAKGTISAPGKVVTAA 816

Query: 1149 RVPSRAAPGKSEPPSKRPLSS----KSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWP 1204
                + +P K +PP + P +S    +   SV +       A   + G E+   SS  +  
Sbjct: 817  AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE-- 874

Query: 1205 SSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPG-SSPRASHVPSRLPP 1263
            S S       A    + +  +   ALAP   S  P K   P PPG + P A+    +   
Sbjct: 875  SDSEEEAETLAQVKPSGKTHQIRAALAPAKES--PRKGAAPTPPGKTGPSAAQAGKQDDS 932

Query: 1264 RSAATVSPVAGTHP 1277
             S++  S   G  P
Sbjct: 933  GSSSEESDSDGEAP 946



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 175/854 (20%), Positives = 290/854 (33%), Gaps = 142/854 (16%)

Query: 471  KPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKA 530
            + +KPE  S S    + S+  +   +     A + +L ++       G P K    A   
Sbjct: 262  RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321

Query: 531  EELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPA 590
            +   + S    G+ E    EDS  S  ++ D +    P ++      A G+T+ +    +
Sbjct: 322  KAGAVASQTKAGKPE----EDSESSSEESSDSEEET-PAAKALLQAKASGKTS-QVGAAS 375

Query: 591  LPRREGVDKPGFSLATQPRPGAPPS--ASASPAHHASTQGTSHRPSLPASLNDNDLVDSD 648
             P +E            PR GA P+      PA   +  G     S  +S       +SD
Sbjct: 376  APAKES-----------PRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS------EESD 418

Query: 649  EDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHS----- 703
             +E A     P G   Q R A +P+++SP            GA PA P +  P +     
Sbjct: 419  SEEEAPAQAKPSGKAPQVRAASAPAKESP----------RKGAAPAPPRKTGPAAAQVQV 468

Query: 704  GAAEEDSSASAPPSRLS------------PPHGGSSRLLPTQPHLSSPLSKGG---KDGE 748
            G  EEDS +S+  S                P G S ++ P       PL KG      G+
Sbjct: 469  GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528

Query: 749  DAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGG-RQAEATAQT 807
              PAT S                    QV +  E S+  S    D  DG    A A AQ 
Sbjct: 529  VGPATPS-------------------AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ- 568

Query: 808  LRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHP---RVPSH 864
                                        S+G   + +P+SSP    P +A P   +V + 
Sbjct: 569  --------------------------EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602

Query: 865  SDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEP 924
                   SS    D  D +  PA +       + + P ++     + +    A +     
Sbjct: 603  KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPK-KTNTTASAKVAPVRV 661

Query: 925  IPENPKSTGADTHPQGKYSSLAS----KAQDVQQSTDADTE----------GHSPKAQPG 970
              + P+  G  T P G   ++A      A+D   S ++D+E          G +     G
Sbjct: 662  GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721

Query: 971  STDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQ 1030
               + AS     +      P +P +  P    Q +      +        S +A  SP+Q
Sbjct: 722  LQVKAASVPVKGSLGQGTAPVLPGKTGP-TVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 1031 PRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQD 1090
             + S+ +       +  R+ S+    +A  + +   A   Q   ++      + +     
Sbjct: 781  VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840

Query: 1091 VRAPAHAARAKEAAASLPKHQQ-VESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRAR 1149
             R PA      +A A+  + Q   E  +G+        +     +  +PS        A 
Sbjct: 841  ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900

Query: 1150 VPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTP 1209
             P++ +P K   P+    +  S    +A+  +++D+G          SSS       S  
Sbjct: 901  APAKESPRKGAAPTPPGKTGPS----AAQAGKQDDSG----------SSS-----EESDS 941

Query: 1210 RGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATV 1269
             G   A  + A+  + P I + P      P   P      S+PR +   S    RS+++ 
Sbjct: 942  DGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARA-SESTARSSSSE 1000

Query: 1270 SPVAGTHPWPQYTT 1283
            S      P  Q  T
Sbjct: 1001 SEDEDVIPATQCLT 1014



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 162/754 (21%), Positives = 276/754 (36%), Gaps = 108/754 (14%)

Query: 513  ILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKR--TLRPPS 570
            +L     P   Q++A+K E+ +    E   EE   S      S   TQ +      R PS
Sbjct: 742  VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 801

Query: 571  RHGHSVVAPGRTAVRA-----RMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
              G ++ APG+    A     R P+  +   V  P  S      P + PS   + A  A 
Sbjct: 802  AKG-TISAPGKVVTAAAQAKQRSPSKVKPP-VRNPQNSTVLARGPASVPSVGKAVATAAQ 859

Query: 626  TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRS 685
             Q      S     +  +  DS+E+   +  + P G   Q R AL+P+++SP        
Sbjct: 860  AQTGPEEDSG----SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP-------- 907

Query: 686  SVHPGAKPASPARRTPHSG-AAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL---- 740
                GA P  P +  P +  A ++D S S+  S  S   G +   + +   +  PL    
Sbjct: 908  --RKGAAPTPPGKTGPSAAQAGKQDDSGSS--SEESDSDGEAPAAVTSAQVIKPPLIFVD 963

Query: 741  ---SKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDG 797
               S  G     A A  ++ P ++  S S +   SS ++  +   A+   +        G
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT-------PG 1016

Query: 798  GRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGR---GPRLQ--------PS 846
             R    T  T   R A            A++ +  SR S G+   GP  Q        P+
Sbjct: 1017 IRTNVVTMPTAHPRIAP-----KASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPA 1071

Query: 847  SSPQST-VPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRG 905
            +SPQST V ++   ++       PKL        E ++   A   +D    SS    S G
Sbjct: 1072 TSPQSTSVQAKGTNKL-----RKPKL-------PEVQQATKAPESSDDSEDSSDS--SSG 1117

Query: 906  WEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSP 965
             E+    PQ   S H   P P   ++   +T  +     + + +Q +           S 
Sbjct: 1118 SEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLL----------SG 1167

Query: 966  KAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAP--QQQPPPPVATSQHHP--GPQS 1021
               PG T  + S A     +    PSV   +     P  +Q+  P  A     P  G + 
Sbjct: 1168 YMTPGLTPAN-SQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKE 1226

Query: 1022 RDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSS-----DPY---TASSRGMLPTALQNQDE 1073
              +G +P + R     AG P+ ++     + +      P+    A  +  +   L    E
Sbjct: 1227 AASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLE 1286

Query: 1074 DAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAA 1133
              +    D + E   +   +        + AA  P+ ++ +   GAG GG+       + 
Sbjct: 1287 QERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKK-KKKLGAGEGGE------ASV 1339

Query: 1134 SPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKE 1193
            SP + S     +++     +A+    E   K  L S+  +    E++ ++  G  +GG +
Sbjct: 1340 SPEKTSTTSKGKAKR---DKASGDVKEKKGKGSLGSQGAKD-EPEEELQKGMGTVEGGDQ 1395

Query: 1194 DLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPA 1227
               S+   K     + +  KD +    K++ + A
Sbjct: 1396 ---SNPKSKKEKKKSDKRKKDKEKKEKKKKAKKA 1426



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 127/673 (18%), Positives = 223/673 (33%), Gaps = 128/673 (19%)

Query: 910  RRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQP 969
            +R  +  A+L  K+    +P ST   +  + +  +  +KA     ST++   G    +  
Sbjct: 62   KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 970  GSTDRHASPARPPAARSQQHPSVPR---RMTPGRAPQQQPPPPVATSQHHPGPQSRDAGR 1026
                +  +        S  HP+  +    +  G++P++   P   T+      ++ + G 
Sbjct: 122  KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS---ETEEEGS 178

Query: 1027 SPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEV 1086
             P+        A +P   S G++ SSS+  ++SS                     D T+V
Sbjct: 179  VPA-----FGAAAKPGMVSAGQADSSSEDTSSSS---------------------DETDV 212

Query: 1087 EAQDVRAPAHAARAKEAAASLPKHQQVESPTGAG------AGG-----------DHRSQR 1129
            E +    PA    +  +    P  +   +P   G       GG           +  S+ 
Sbjct: 213  EGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESES 272

Query: 1130 GHAASPARPSRPGGPQSR------------ARVPSRAAPGKS---EPPSKRPLSSKSQQS 1174
                S +    P G +S+            A  P++  PGK     PP K    +   ++
Sbjct: 273  SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332

Query: 1175 VSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRG 1234
               E+D E  +      +E+  ++       +S       A  + AKE      A AP G
Sbjct: 333  GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392

Query: 1235 GSLAPVKR------------------------PLPPPPGSSP--RASHVPSRLPPRSAAT 1268
             +   V +                            P G +P  RA+  P++  PR  A 
Sbjct: 393  KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 452

Query: 1269 VSPVAGTHP---WPQYTTRAPPGHFSTTPMLSLRQRM--MHARFRNPLSRQP-ARPSYRQ 1322
             +P   T P     Q   +      S+    S R+ +  M+A    PL + P  +P+   
Sbjct: 453  PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM 512

Query: 1323 GY-----NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSH 1377
            G         P   GKV P +     G+   +    ++   D   G V  A     + S 
Sbjct: 513  GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572

Query: 1378 GNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGL 1437
            GN L+ K                  P   P  G  +   P+A      +     KP+   
Sbjct: 573  GNILQAK------------------PTSSPAKGPPQKAGPVA------VQVKAEKPMDNS 608

Query: 1438 EVIKKTTHPPTTTMQPT--TTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTT 1495
            E  ++++    +   P   T     P    P+ T A  ++T TT            +   
Sbjct: 609  ESSEESSDSADSEEAPAAMTAAQAKPALKIPQ-TKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 1496 RTTTTTTPTPTTP 1508
            +  T T+P  ++P
Sbjct: 668  KAGTATSPAGSSP 680


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo
            sapiens]
          Length = 958

 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 192/854 (22%), Positives = 310/854 (36%), Gaps = 142/854 (16%)

Query: 456  TTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILA 515
            T+S +D    T+  GKP   +P+     + ++ + P+  A+P      D+   +K   L 
Sbjct: 203  TSSSSD---ETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258

Query: 516  NGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHS 575
                 +KP+  ++ +EE     +E   E   G+R  S +  S+   Q R    P++    
Sbjct: 259  PAKRAKKPEEESESSEE----GSESEEEAPAGTR--SQVKASEKILQVRAASAPAKG--- 309

Query: 576  VVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSL 635
               PG+ A     PA P + G      ++A+Q + G P   S S +  +S          
Sbjct: 310  --TPGKGAT----PAPPGKAG------AVASQTKAGKPEEDSESSSEESS---------- 347

Query: 636  PASLNDNDLVDSDEDERAVGSL---HPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAK 692
                      DS+E+  A  +L      G  +Q   A +P+++SP            GA 
Sbjct: 348  ----------DSEEETPAAKALLQAKASGKTSQVGAASAPAKESP----------RKGAA 387

Query: 693  PASPARRTP-----HSGAAEEDSSASAPPS---RLSPPHGGSSRLLPTQPHLSSPLSKGG 744
            PA P +  P      +G  EEDS +S+  S     +P     S   P     S+P  +  
Sbjct: 388  PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447

Query: 745  KDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEAT 804
            + G  AP     AP R T  ++         QV  G +  D  S    +  D  R+A A 
Sbjct: 448  RKGA-AP-----APPRKTGPAA--------AQVQVGKQEED--SRSSSEESDSDREALAA 491

Query: 805  AQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSH 864
                + +P      +   KP +  G  P    +G+G    P        PS    +    
Sbjct: 492  MNAAQVKPLGKSPQV---KPASTMGMGP----LGKGAGPVPPGKVGPATPSAQVGKWEED 544

Query: 865  SDSHPKLSSGIHGDEEDEKPLPA------TVVNDHVPSSSRQPISRGWEDLRRSPQRGAS 918
            S+S  + SS     E      PA       ++     SS  +   +    +    +    
Sbjct: 545  SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 604

Query: 919  LHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASP 978
            +   E   E+  S  ++  P    ++ A  A  + Q+          KA P  T+  AS 
Sbjct: 605  MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT----------KACPKKTNTTASA 654

Query: 979  ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPR---LSL 1035
               P     Q    PR+     +P     P VA     P   S  +  S S+     L++
Sbjct: 655  KVAPVRVGTQ---APRKAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAV 710

Query: 1036 TQAGRPRPTSQG-RSHSSSDPYTAS-SRGMLP-----TALQNQDEDAQGSYDDDSTEVEA 1088
            T  G+ +   +G +  ++S P   S  +G  P     T        A+   D +S+E E+
Sbjct: 711  T-VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769

Query: 1089 QDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRA 1148
                A A  A+ K    S+ K Q   +P  A A           ++    S PG   + A
Sbjct: 770  DSEEAAASPAQVK---TSVKKTQAKANPAAARA----------PSAKGTISAPGKVVTAA 816

Query: 1149 RVPSRAAPGKSEPPSKRPLSS----KSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWP 1204
                + +P K +PP + P +S    +   SV +       A   + G E+   SS  +  
Sbjct: 817  AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE-- 874

Query: 1205 SSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPG-SSPRASHVPSRLPP 1263
            S S       A    + +  +   ALAP   S  P K   P PPG + P A+    +   
Sbjct: 875  SDSEEEAETLAQVKPSGKTHQIRAALAPAKES--PRKGAAPTPPGKTGPSAAQAGKQDDS 932

Query: 1264 RSAATVSPVAGTHP 1277
             S++  S   G  P
Sbjct: 933  GSSSEESDSDGEAP 946



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 127/673 (18%), Positives = 223/673 (33%), Gaps = 128/673 (19%)

Query: 910  RRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQP 969
            +R  +  A+L  K+    +P ST   +  + +  +  +KA     ST++   G    +  
Sbjct: 62   KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 970  GSTDRHASPARPPAARSQQHPSVPR---RMTPGRAPQQQPPPPVATSQHHPGPQSRDAGR 1026
                +  +        S  HP+  +    +  G++P++   P   T+      ++ + G 
Sbjct: 122  KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS---ETEEEGS 178

Query: 1027 SPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEV 1086
             P+        A +P   S G++ SSS+  ++SS                     D T+V
Sbjct: 179  VPA-----FGAAAKPGMVSAGQADSSSEDTSSSS---------------------DETDV 212

Query: 1087 EAQDVRAPAHAARAKEAAASLPKHQQVESPTGAG------AGG-----------DHRSQR 1129
            E +    PA    +  +    P  +   +P   G       GG           +  S+ 
Sbjct: 213  EGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESES 272

Query: 1130 GHAASPARPSRPGGPQSR------------ARVPSRAAPGKS---EPPSKRPLSSKSQQS 1174
                S +    P G +S+            A  P++  PGK     PP K    +   ++
Sbjct: 273  SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332

Query: 1175 VSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRG 1234
               E+D E  +      +E+  ++       +S       A  + AKE      A AP G
Sbjct: 333  GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392

Query: 1235 GSLAPVKR------------------------PLPPPPGSSP--RASHVPSRLPPRSAAT 1268
             +   V +                            P G +P  RA+  P++  PR  A 
Sbjct: 393  KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 452

Query: 1269 VSPVAGTHP---WPQYTTRAPPGHFSTTPMLSLRQRM--MHARFRNPLSRQP-ARPSYRQ 1322
             +P   T P     Q   +      S+    S R+ +  M+A    PL + P  +P+   
Sbjct: 453  PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM 512

Query: 1323 GY-----NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSH 1377
            G         P   GKV P +     G+   +    ++   D   G V  A     + S 
Sbjct: 513  GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572

Query: 1378 GNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGL 1437
            GN L+ K                  P   P  G  +   P+A      +     KP+   
Sbjct: 573  GNILQAK------------------PTSSPAKGPPQKAGPVA------VQVKAEKPMDNS 608

Query: 1438 EVIKKTTHPPTTTMQPT--TTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTT 1495
            E  ++++    +   P   T     P    P+ T A  ++T TT            +   
Sbjct: 609  ESSEESSDSADSEEAPAAMTAAQAKPALKIPQ-TKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 1496 RTTTTTTPTPTTP 1508
            +  T T+P  ++P
Sbjct: 668  KAGTATSPAGSSP 680


>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
          Length = 5478

 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 276/1345 (20%), Positives = 429/1345 (31%), Gaps = 198/1345 (14%)

Query: 327  PDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTA-PENLNVWPVNGKPTVVAASWDAL 385
            PD     A   S G  +    +S     P S  TTA P++     ++ +PT   +S    
Sbjct: 3007 PDATLSPATTTSSGVSE---ESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSS---- 3059

Query: 386  PETEGKVKEYILSYAPALKPFGAKSLTY---PGDT----------TSALVDGLQPGERYL 432
               +G  +  +   +      G +S T+   PGDT          TS LV+   P     
Sbjct: 3060 ---QGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSST 3116

Query: 433  FKIRAT------NRRGLGPHSKAF---------IVAMPTTSKADVEQNTEDNGKPEKPEP 477
              +  T         GL   S  F           + P T+ A VE +T  + +P     
Sbjct: 3117 GSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPT 3176

Query: 478  ---SSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELD 534
               S+ S     S +  +V +SP        L   ++      G P    + +   E   
Sbjct: 3177 THFSASSTTLGRSEESTTVHSSPGATGTA--LFPTRSATSVLVGEPTTSPISSGSTETTA 3234

Query: 535  LQSTEITG--EEELGSREDSPMSPSDTQDQKRTLRPP---------SRHG--HSVVAPGR 581
            L  +  T    E+  +   SP SP  T     T             SR G  H+   PG 
Sbjct: 3235 LPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGS 3294

Query: 582  TAVRARMPALPRREGVD--KPGFSLATQPRPGAPPSASASPAHHA--STQGTSHRPSLPA 637
            T     MP + +        PG S  T   PG+  ++S  P      S  G++    LP 
Sbjct: 3295 TT----MPGVSQESTASHSSPG-STDTTLSPGSTTASSLGPESTTFHSGPGSTETTLLPD 3349

Query: 638  SLNDNDLVDSDED-ERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASP 696
            +   + L+++      + GS H   +     PA S +RQ  S+  +      P +K  +P
Sbjct: 3350 NTTASGLLEASTPVHSSTGSPHTTLS-----PAGSTTRQGESTTFQS----WPNSKDTTP 3400

Query: 697  ARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSN 756
            A  T  S   E  +++   PS     H  +S         S+ L +     E++   +S+
Sbjct: 3401 APPTTTSAFVELSTTSHGSPSSTPTTHFSAS---------STTLGRS----EESTTVHSS 3447

Query: 757  APSRSTMSSSVSSHLSSRTQVSEGAEASDGES---HGDGDREDGGRQAEATAQTLRARPA 813
              + +T  S   S  S   + S    +S G +   H        GR  E+T         
Sbjct: 3448 PVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSH------ 3501

Query: 814  SGHFHLLRHKPFAANG--RSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKL 871
            S   H +   P   +     P+ +    G          ST   R+     SHS      
Sbjct: 3502 SSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQ---- 3557

Query: 872  SSGIHGDEEDEKPLPA-TVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPK 930
                  D      LPA +  +  +  S+  PIS G  +    P    +    E      K
Sbjct: 3558 ------DATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSE------K 3605

Query: 931  STGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHP 990
            ST   + P+   ++L+  +      ++  T  HS   +PGST   A P         +H 
Sbjct: 3606 STTFHSSPRSPATTLSPASTTSSGVSEESTTSHS---RPGSTHTTAFPDSTTTPGLSRH- 3661

Query: 991  SVPRRMTPGRAPQQQPPPPVATS-------QHHPGPQSRDAGRSP-SQPRLSLTQAGRPR 1042
            S     +PG       P    TS         H    S D   SP S   LS  Q     
Sbjct: 3662 STTSHSSPGSTDTTLLPASTTTSGSSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTF 3721

Query: 1043 PTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKE 1102
             +S G +H++  P + +S G++  + +        S     T +      +P     +  
Sbjct: 3722 HSSPGSTHTTLFPDSTTSSGIVEASTR-----VHSSTGSPRTTLSPASSTSPGLQGESTA 3776

Query: 1103 AAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPP 1162
                        SP          S   H +  + P+      S     S  +      P
Sbjct: 3777 FQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSP 3836

Query: 1163 SKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKE 1222
                 +  S  S ++   E   +    G      S+ +   P S+T  G  +A  +    
Sbjct: 3837 DASGTTPSSAHSTTSGRGESTTSRISPG------STEITTLPGSTTTPGLSEASTTFYSS 3890

Query: 1223 EREPAIALAPRGGSLAPV---KRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWP 1279
             R P   L+P   +   V          PGS+       S   P  +   + V  + P  
Sbjct: 3891 PRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGS 3950

Query: 1280 QYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSN 1339
              TT  P    +TT +        H+R  +  +      S   G       E    PGS 
Sbjct: 3951 TETTVFP--RSTTTSVRREEPTTFHSRPASTHTTLFTEDSTTSGL----TEESTAFPGSP 4004

Query: 1340 GKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTP 1399
                      G   T    D      L  E      S G+    KL     T   L G  
Sbjct: 4005 ASTQ-----TGLPATLTTAD------LGEESTTFPSSSGS-TGTKLSPARSTTSGLVGES 4052

Query: 1400 VVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTP 1459
              S     L       T L  +   P LS            +K+T   T+   P  T +P
Sbjct: 4053 TPS----RLSPSSTETTTLPGSPTTPSLS------------EKSTTFYTSPRSPDATLSP 4096

Query: 1460 LPTTTT------------PRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTT 1507
              TT++            P  T  T    +TT    ++ PTT+  +   T  T +P  TT
Sbjct: 4097 ATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGSTEATLSPGSTT 4156

Query: 1508 PIPTCPPGTLERHDDDGNLIMS-------SNGIPECYAEEDEFSGLETDTAVPTEEAYV- 1559
                    T   H   G+   +       ++G+ E        +G    T  P       
Sbjct: 4157 ASSLGQQST-TFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSTG 4215

Query: 1560 IYDEDYEFETSRPPTTTEPSTTATT 1584
            + +E   F++    + T PS  +TT
Sbjct: 4216 LQEESTTFQSWPSSSDTTPSPPSTT 4240



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 243/1191 (20%), Positives = 385/1191 (32%), Gaps = 152/1191 (12%)

Query: 396  ILSYAPALKPFGAKSL---TYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIV 452
            +L   P   P  + S      PG TT+A   GL       +    +    L P S     
Sbjct: 1658 VLVGEPTTSPISSGSTETTALPGSTTTA---GLSEKSTTFYSSPRSPDTTLSPAS----- 1709

Query: 453  AMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVP----ASPQGRNAKDLLLD 508
               TTS    E++T  + +P     S+ +   P S+  P V     AS     + D  L 
Sbjct: 1710 ---TTSSGVSEESTTSHSRPG----STHTTAFPGSTTMPGVSQESTASHSSPGSTDTTLS 1762

Query: 509  LKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRP 568
              +   ++ G        +  + E  L     T     G  E S    S T     TL P
Sbjct: 1763 PGSTTASSLGPESTTFHSSPGSTETTLLPDNTTAS---GLLEASTPVHSSTGSPHTTLSP 1819

Query: 569  P---SRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
                +R G S       + +  MPA P         F   +    G+P   S++P  H S
Sbjct: 1820 AGSTTRQGESTTFQSWPSSKDTMPAPPTTTSA----FVELSTTSHGSP---SSTPTTHFS 1872

Query: 626  TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRS 685
               T+              +   E+   V S  P      P    SP+R + S ++ + +
Sbjct: 1873 ASSTT--------------LGRSEESTTVHS-SPVATATTP----SPARSTTSGLVEEST 1913

Query: 686  SVH--PGAKPAS--PARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLL--PTQPHLSSP 739
            + H  PG+      P   T    + E  +S S+    +S P   +S L+  PT  H SSP
Sbjct: 1914 AYHSSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYH-SSP 1972

Query: 740  LSKGGKDGEDAPATNSNAPSRSTMSSSVSSH------LSSRTQVSEGAEASDGESHGD-- 791
             S       D+  T+  +   +   SS  +         S T V  G   +   S G   
Sbjct: 1973 GSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSME 2032

Query: 792  -----GDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPS 846
                 G     G   ++T  T  + P S    L      ++     S  S  R      +
Sbjct: 2033 TTALPGSTTTPGLSEKST--TFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTT 2090

Query: 847  SSPQSTV-PSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRG 905
            + P ST  P  +     SHS      ++ +        P   +  +   P S+   +S G
Sbjct: 2091 AFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPG 2150

Query: 906  WEDLRRSPQRGASLHRKEP------IPENPKSTGADTHPQGKYSSLASKAQDVQ--QSTD 957
                    Q   + H           P++  S+G        +SS  S    +    ST 
Sbjct: 2151 STTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTS 2210

Query: 958  ADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHP 1017
               +G S   Q      H +P+ P  A +    S     +PG  P    P    TS H  
Sbjct: 2211 PGLQGESTAFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGH-- 2268

Query: 1018 GPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGM--LP--TALQNQDE 1073
               S  +    S P  S T       T+ GR  S++   +  S  +  LP  T      E
Sbjct: 2269 ---SEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSE 2325

Query: 1074 DAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPK----HQQVESPTGAGAGGDHRSQR 1129
             +   Y    +        +       +E+  S  +    H  V   +    G    S  
Sbjct: 2326 ASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTT 2385

Query: 1130 GHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFK 1189
             +++SP        P    R P+ +  G+ EP +     + +  ++  ED          
Sbjct: 2386 VYSSSPGSTETTVFP----RTPTTSVRGE-EPTTFHSRPASTHTTLFTEDSTTS------ 2434

Query: 1190 GGKEDLLSSSVPKWPSSS-TPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPP 1248
            G  E+  S++ P  P+S+ T          L +E      +    G +L+P +       
Sbjct: 2435 GLTEE--STAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLV 2492

Query: 1249 GSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFR 1308
            G S      PSRL P S  T +                PG   TTP LS +    +   R
Sbjct: 2493 GES-----TPSRLSPSSTETTTL---------------PGS-PTTPSLSEKSTTFYTSPR 2531

Query: 1309 NPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNA 1368
            +P +      +   G +   +        S+ +P        P  T     L R    + 
Sbjct: 2532 SPDATLSPATTTSSGVSEESST-------SHSQPGSTHTTAFPDSTT-TPGLSRHSTTSH 2583

Query: 1369 EGRYLQDSHGNPLRIKLGGDGRTIVDLEGTP-----VVSPDGLPLFGQGRHGTPLANAQD 1423
                  D+   P      G  +       +P      +SP        G+  T   ++  
Sbjct: 2584 SSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPG 2643

Query: 1424 KPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT 1483
                +L         +++ +T   ++T  P TT +P  +T+      +TT +T      T
Sbjct: 2644 STHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTTFQTHPASTHT 2703

Query: 1484 TRRPTTTVRTTTRTTTT----TTPTPTTPIPTCPPGTLERHDDDGNLIMSS 1530
            T  P +T       +TT       TPTT  P     T   H +   +  SS
Sbjct: 2704 TPSPPSTATAPVEESTTYHRSPGSTPTTHFPA--SSTTSGHSEKSTIFHSS 2752



 Score = 71.2 bits (173), Expect = 9e-12
 Identities = 289/1383 (20%), Positives = 459/1383 (33%), Gaps = 224/1383 (16%)

Query: 348  TSVFQRTPESAPTT--------APENLNVWPVNGKPTVVAASWD-ALPETEGKVKEYILS 398
            ++ +  +P S PTT           +    PV+  P   A +   A   T G V+E   S
Sbjct: 445  STTYHSSPSSTPTTHFSASSTTLGHSEESTPVHSSPVATATTPPPARSATSGHVEE---S 501

Query: 399  YAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIV------ 452
             A    P   +++ +P  +T++        E   F    T+ +   P + A +       
Sbjct: 502  TAYHRSPGSTQTMHFPESSTTSG----HSEESATFHGSTTHTKSSTPSTTAALAHTSYHS 557

Query: 453  AMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHP--SVPASPQGRNAKDLLLDLK 510
            ++ +T       ++  +G+ E+ + S  SP A A++  P  S P+   G +    +    
Sbjct: 558  SLGSTETTHFRDSSTISGRSEESKASHSSPDAMATTVLPAGSTPSVLVGDSTPSPISSGS 617

Query: 511  NKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPS 570
             +  A  G+  KP L  K        ST              P S + +   + +    S
Sbjct: 618  METTALPGSTTKPGLSEK--------STTFYSSPRSPDTTHLPASMTSSGVSEESTTSHS 669

Query: 571  RHG--HSVVAPGRTAVRARMPALPRREGVD--KPGFSLATQPRPGAPPSASASPAHHA-- 624
            R G  H+   PG T     MP L +        PG    T   PG+  ++S  P +    
Sbjct: 670  RPGSTHTTAFPGSTT----MPGLSQESTASHSSPG-PTDTTLSPGSTTASSLGPEYTTFH 724

Query: 625  STQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPS----RQSPSSV 680
            S  G++    LP +   + L+++        S+    +   P   LSP+    RQ  S+ 
Sbjct: 725  SRPGSTETTLLPDNTTASGLLEA--------SMPVHSSTRSPHTTLSPAGSTTRQGESTT 776

Query: 681  LRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGG-----SSRLLPTQPH 735
                    P +K   PA  T  S   E  +++   PS +   H       S  +  +  +
Sbjct: 777  FHS----WPSSKDTRPAPPTTTSAFVEPSTTSHGSPSSIPTTHISARSTTSGLVEESTTY 832

Query: 736  LSSPLS--------KGGKDGEDAPATNSNAPSRSTMSS--SVSSHLSSRTQVSEGAEASD 785
             SSP S             G    +T S++ +  T+SS  S +S L         +  S 
Sbjct: 833  HSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGST 892

Query: 786  GESHGDGDREDGGRQAEATAQTLRARPASGHFHL-LRHKPFAANGRS-PSRFSIGR---- 839
              +H        GR  E+TA +  ++ A+G   L  R       G S  S  S G     
Sbjct: 893  ATTHFPDSSTTSGRSEESTA-SHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETT 951

Query: 840  ---GPRLQPSSSPQSTVPSRAHPRVPSHSDSHPK-LSSGIHGDEEDEKPLPATVVNDHVP 895
               G    P  S +ST    + PR P+ + S     SSG+  +    +  P +      P
Sbjct: 952  ALPGSTTTPGLSERSTT-FHSSPRSPATTLSPASTTSSGVSEESTTSRSRPGSTHTTAFP 1010

Query: 896  SSSRQP-ISRGWEDLRRSP------------------QRGASLHRKEPIPENPKSTGADT 936
             S+  P +SR       SP                  Q   + H      +   S G+ T
Sbjct: 1011 DSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSSGSTDTALSPGSTT 1070

Query: 937  -------------HPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARP-- 981
                         +P   +++L   +       +A T  HS    P +T   AS   P  
Sbjct: 1071 ALSFGQESTTFHSNPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGL 1130

Query: 982  --PAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAG 1039
               +   Q HP+     T    P     P   ++ +H  P S      P+    S T +G
Sbjct: 1131 QGESTAFQTHPASTH--TTPSPPSTATAPVEESTTYHRSPGSTPTTHFPA----SSTTSG 1184

Query: 1040 RPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAAR 1099
                ++   S   +   T SS     +    + E         STE+       P     
Sbjct: 1185 HSEKSTIFHSSPDASGTTPSS---AHSTTSGRGESTTSRISPGSTEI----TTLPGSTTT 1237

Query: 1100 AKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKS 1159
               + AS   +    SPT   +     S      S    S+PG   S     S   PG S
Sbjct: 1238 PGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLS 1297

Query: 1160 EPPSKRPLSSKSQ-------QSVSAEDDEEEDAGFF-----------------KGGKEDL 1195
            E  +    SS+          S +     EE   F                   G  E+ 
Sbjct: 1298 EESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTTLFTEDSTTSGLTEE- 1356

Query: 1196 LSSSVPKWPSSS-TPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRA 1254
             S++ P  P+S+ T          L +E      +    G  L+P +       G S   
Sbjct: 1357 -STAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGES--- 1412

Query: 1255 SHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQ 1314
               PSRL P S  T +                PG   TTP LS +    +   R+P +  
Sbjct: 1413 --TPSRLSPSSTETTT---------------LPGS-PTTPSLSEKSTTFYTSPRSPDATL 1454

Query: 1315 PARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQ 1374
                +   G +   +        S+ +P        P  T    DL +    +   +   
Sbjct: 1455 SPATTTSSGVSEESST-------SHSQPGSTHTTAFPDSTT-TSDLSQEPTTSHSSQGST 1506

Query: 1375 D---SHGNPLRIKLGGDGRTIVDLEG--TPVVSPDGLPLFGQGRHGTPLANAQDK--PIL 1427
            +   S G+     LG    T     G     + PD     G     TP  ++       L
Sbjct: 1507 EATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTL 1566

Query: 1428 SLGGKPLVGLEVIKKTTHPPTTTMQ---PTTTTTPLPTTTTPRP----TTATTRRTTTTR 1480
            +       GL+         +TT Q    ++ TTP P  TT  P    TT  +R ++T  
Sbjct: 1567 TPASSTSAGLQ-------EESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPT 1619

Query: 1481 RTTTRRPTTTVRTTTRTTTTTTP--TPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYA 1538
               +   TT  R+   TT  ++P  T T   PT    ++   +   + I S +       
Sbjct: 1620 THFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGS------T 1673

Query: 1539 EEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEP---STTATTPRVIPEEGAIS 1595
            E     G  T TA  +E++   Y      +T+  P +T     S  +TT    P     +
Sbjct: 1674 ETTALPG-STTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTT 1732

Query: 1596 SFP 1598
            +FP
Sbjct: 1733 AFP 1735



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 262/1275 (20%), Positives = 403/1275 (31%), Gaps = 176/1275 (13%)

Query: 451  IVAMPTTSKADVEQNTEDNGKPEK------PEPSSPSPRAPASS-QHPSVPAS-----PQ 498
            I + P+T+ A VE+ T  +  P        P+ S+ S R+  S+  H S  A+     P 
Sbjct: 1951 ISSPPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPA 2010

Query: 499  GRNAKDLLLDLKNKILANG--------GAPRKPQLRAKK----------AEELDLQSTEI 540
                  LL +     +++G        G+   P L  K           A  L   ST  
Sbjct: 2011 RSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPATTLSPASTTS 2070

Query: 541  TG-EEELGSREDSPMSPSDTQDQKRTLRPP-SRHGH-SVVAPGRTAVRARMPALPRREGV 597
            +G  EE  +    P S   T     T  P  SRH   S  +PG T     +PA     G 
Sbjct: 2071 SGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTL-LPASTTTSGP 2129

Query: 598  DKPGFSLATQP-------RPGAPPSAS---ASPAHHASTQGTSHRPSLPASLNDNDLVDS 647
             +   +  + P        PG+  + S    S   H+S  G++H    P S   + +V++
Sbjct: 2130 SQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSP-GSTHTTLFPDSTTSSGIVEA 2188

Query: 648  DEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSV---HPGAKPASPARRTPHSG 704
                    S     +   PR  LSP+  S S  L+  S+    HP +   +P+  +  + 
Sbjct: 2189 --------STRVHSSTGSPRTTLSPA-SSTSPGLQGESTAFQTHPASTHTTPSPPSTATA 2239

Query: 705  AAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL-SKGGKDGEDAPATNSNAPSRSTM 763
              EE ++    P      H  +S         S+   S     G    + +S    R   
Sbjct: 2240 PVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGES 2299

Query: 764  SSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEAT--------------AQTLR 809
            ++S  S  S+      G+  + G S          R    T              + T R
Sbjct: 2300 TTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSR 2359

Query: 810  ARPASGHFHL---------LRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPR 860
            ++P S H  +         L  +       SP        PR  P++S +   P+  H R
Sbjct: 2360 SQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRT-PTTSVRGEEPTTFHSR 2418

Query: 861  VPS-HSD--SHPKLSSGIHGDE--------EDEKPLPATVVN-DHVPSSSRQPISRGWED 908
              S H+   +    +SG+  +           +  LPAT+   D    S+  P S G   
Sbjct: 2419 PASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTG 2478

Query: 909  LRRSPQRGAS---LHRKEPIPENPKSTGADTHPQGKYS-SLASKAQD------------- 951
               SP R  +   +    P   +P ST   T P    + SL+ K+               
Sbjct: 2479 TTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLS 2538

Query: 952  --VQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPP 1009
                 S+    E  +  +QPGST   A P         +H S     +PG       P  
Sbjct: 2539 PATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTPGLSRH-STTSHSSPGSTDTTLLPAS 2597

Query: 1010 VATS-------QHHPGPQSRDAGRSP-SQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSR 1061
              TS         H  P S D   SP S   LS  Q      +S G +H++  P + +S 
Sbjct: 2598 TTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSS 2657

Query: 1062 GMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGA 1121
            G++  + +        S     T +      +P     +              SP     
Sbjct: 2658 GIVEASTR-----VHSSTGSPRTTLSPASSTSPGLQGESTTFQTHPASTHTTPSPPSTAT 2712

Query: 1122 GGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDE 1181
                 S   H +  + P+      S     S  +      P     +  S  S ++   E
Sbjct: 2713 APVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGE 2772

Query: 1182 EEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRG------G 1235
               +    G      S+ +   P S+T  G  +A  +     R P   L+P        G
Sbjct: 2773 STTSRISPG------STEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVG 2826

Query: 1236 SLAPVKRPLPPPPGS--SPRASHVPSRLPPRSAATVSPVAG---THPWPQYTTRAPPGHF 1290
              +   R  P    S  SP ++  P  L   S    S   G   T  +P+ TT +  G  
Sbjct: 2827 EESTTSRSQPGSTHSTVSPASTTTPG-LSEESTTVYSSSPGSTETTVFPRSTTTSVRGEE 2885

Query: 1291 STTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPN-GQRIIN 1349
             TT     R    H       S           + G P      LP +    + G+    
Sbjct: 2886 PTT--FHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTT 2943

Query: 1350 GPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLF 1409
             P  +        G  L+          G     +L         L G+P       P  
Sbjct: 2944 FPSSSG-----STGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTT-----PSL 2993

Query: 1410 GQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPP-----TTTMQPTTTTTPLPTTT 1464
             +       +       LS       G+     T+H       TT    +TTT+ L    
Sbjct: 2994 SEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEP 3053

Query: 1465 TPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLE----RH 1520
            T   ++  +   T +  +TT        TT  ++   T T   P  T   G +E     H
Sbjct: 3054 TASHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTH 3113

Query: 1521 DDDGNL-------IMSSNGIPECYAEEDEFSGLETDTAVP--TEEAYVIYDEDYEFETSR 1571
               G+L         +S G+ E       +      T  P  T  A V     Y    S 
Sbjct: 3114 SSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSS 3173

Query: 1572 PPTTTEPSTTATTPR 1586
             PTT   +++ T  R
Sbjct: 3174 TPTTHFSASSTTLGR 3188



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 250/1261 (19%), Positives = 394/1261 (31%), Gaps = 187/1261 (14%)

Query: 456  TTSKADVEQNTEDNGKPEKPEPSS--PSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKI 513
            TTS    E++T  + +P     ++   S   P  S+H +   S  G     LL       
Sbjct: 3625 TTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLL------- 3677

Query: 514  LANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQ-----DQKRTLRP 568
                            +      S E T         D+ +SP  T       +  T   
Sbjct: 3678 --------------PASTTTSGSSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHS 3723

Query: 569  PSRHGHSVVAPGRTAVRARMPALPR---REGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
                 H+ + P  T     + A  R     G  +   S A+   PG    ++A   H AS
Sbjct: 3724 SPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPAS 3783

Query: 626  TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRS 685
            T  T   PS   +     + +S    R+ GS           P       S +S   ++S
Sbjct: 3784 THTTPSPPSTATA----PVEESTTYHRSPGST----------PTTHFPASSTTSGHSEKS 3829

Query: 686  SVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSP-LSKGG 744
            ++   +  AS    TP S  +       +  SR+SP   GS+ +       ++P LS+  
Sbjct: 3830 TIFHSSPDASGT--TPSSAHSTTSGRGESTTSRISP---GSTEITTLPGSTTTPGLSEAS 3884

Query: 745  KDGEDAPATNSNAPSRSTMSS---------SVSSHLSSRTQVSEGAEASDGESH------ 789
                 +P + +   S ++M+S         S S   S+ + VS  +  + G S       
Sbjct: 3885 TTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVY 3944

Query: 790  --GDGDRED---------GGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIG 838
                G  E            R+ E T  T  +RPAS H  L       +     S    G
Sbjct: 3945 SSSPGSTETTVFPRSTTTSVRREEPT--TFHSRPASTHTTLFTEDSTTSGLTEESTAFPG 4002

Query: 839  RGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSS 898
                  P+S+      +     +   S + P  S          +   + +V +  PS  
Sbjct: 4003 -----SPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRL 4057

Query: 899  RQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDA 958
              P S     L  SP   +   +      +P+S  A   P    SS  S+          
Sbjct: 4058 -SPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSE---------- 4106

Query: 959  DTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATS----- 1013
              E  +  +QPGST   A P     +   Q P+              P    A+S     
Sbjct: 4107 --ESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQS 4164

Query: 1014 -QHHPGPQSRDAGRSPSQPRLS-LTQAGRPRPTSQGRSHSSSDPYTASSRGML--PTALQ 1069
               H  P   +    P     S L +A  P  +S G  H++  P +++S G+    T  Q
Sbjct: 4165 TTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSTGLQEESTTFQ 4224

Query: 1070 NQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKE-----AAASLPKHQQVESPT---GAGA 1121
            +    +  +    ST     +V    H+  +       +A+S    +  ES T     GA
Sbjct: 4225 SWPSSSDTTPSPPSTTAVPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGA 4284

Query: 1122 GGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDE 1181
             G        A S         P S     + A PG +        S+    S  + D  
Sbjct: 4285 TGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTT 4344

Query: 1182 EEDAGFFKGG--KEDLLSSSVP------KWPSSSTPRGGKDADGSLAKEEREPAIALAP- 1232
               A     G  +E   S S P       +PSS+T  G      +           L+P 
Sbjct: 4345 LSPASTTSSGVSEESTTSHSRPGSMHTTAFPSSTTMPGVSQESTASHSSPGSTDTTLSPG 4404

Query: 1233 --RGGSLAPVKRPLPPPPGS--------SPRASHVPSRLPPRSAATVSPVAGTHP----- 1277
                 SL P        PGS        +  AS +     P  ++T SP     P     
Sbjct: 4405 STTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTT 4464

Query: 1278 ----------WP--QYTTRAPPGHFSTTPMLSLRQR--------MMHARFRNPLSRQPAR 1317
                      WP  + TT APP   S    LS               +     L R    
Sbjct: 4465 RQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEES 4524

Query: 1318 PSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSH 1377
             +                  ++G        +   G+   +        +  G     SH
Sbjct: 4525 TTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRGEESTTSH 4584

Query: 1378 GNPLRIKLGGDGRTIVDLE---------GTPVVS--PDGLPLFGQGRHGTPLANAQDKP- 1425
             +           T   +E         G+   +  PD     G+    T   ++QD   
Sbjct: 4585 SSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATG 4644

Query: 1426 ILSLGGKPLVGLEVIKKTTHPPT-----TTMQPTTTTTPLPTTTTPRPTTATTRRTTTTR 1480
             + L  +    + + + TT P +     TT  P +TTTP     + + TT  +  ++T  
Sbjct: 4645 TIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTP---GLSEKSTTFHSSPSSTPT 4701

Query: 1481 RTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPEC--YA 1538
               +   TT  R+   TT  ++P  T   P+    T     ++     SS G  +   + 
Sbjct: 4702 THFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFP 4761

Query: 1539 EEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFP 1598
            E    SG        +EE+   +       +S P TT+      T+    P   A + FP
Sbjct: 4762 ESSTASG-------RSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTHFP 4814

Query: 1599 E 1599
            E
Sbjct: 4815 E 4815



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 238/1158 (20%), Positives = 367/1158 (31%), Gaps = 154/1158 (13%)

Query: 478  SSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELD--L 535
            S+PS  +P+S++  ++P SP   +       L  K      +PR P      A      +
Sbjct: 1412 STPSRLSPSSTETTTLPGSPTTPS-------LSEKSTTFYTSPRSPDATLSPATTTSSGV 1464

Query: 536  QSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHG-----HSVVAPGRTAVRARMPA 590
                 T   + GS   +   P  T     +  P + H       + ++PG T   A    
Sbjct: 1465 SEESSTSHSQPGSTHTTAF-PDSTTTSDLSQEPTTSHSSQGSTEATLSPGSTT--ASSLG 1521

Query: 591  LPRREGVDKPGFSLATQPRPGAPPS--ASASPAHHASTQGTSHRPSLPASLNDNDLVDSD 648
                     PG +  T        S    AS   H+ST G+ H    PAS     L +  
Sbjct: 1522 QQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSST-GSLHTTLTPASSTSAGLQEES 1580

Query: 649  EDERAVGSL-----HPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHS 703
               ++  S       P G  A P    +     PSS      S        S    T H 
Sbjct: 1581 TTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVH- 1639

Query: 704  GAAEEDSSASAPPSRLSPPHGGSSRLL--PTQPHLSSPLSKGGKDGEDAPATNSNAPSRS 761
                  SS  A  + L P    +S L+  PT    +SP+S G  +    P + + A    
Sbjct: 1640 ------SSPGATGTALFPTRSATSVLVGEPT----TSPISSGSTETTALPGSTTTAGLSE 1689

Query: 762  TMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLR 821
              ++  SS  S  T +S  +  S G S             E+T  T  +RP S H     
Sbjct: 1690 KSTTFYSSPRSPDTTLSPASTTSSGVSE------------EST--TSHSRPGSTHTTAFP 1735

Query: 822  HKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDE-- 879
                       S  S         + SP ST  S   P   +   S     + +  D   
Sbjct: 1736 GSTTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTT 1795

Query: 880  -----EDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGA 934
                 E   P+ ++  + H   S     +R  E         +    K+ +P  P +T A
Sbjct: 1796 ASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPSS----KDTMPAPPTTTSA 1851

Query: 935  DTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPR 994
                        S       S  + T G S +    ST  H+SP           PS  R
Sbjct: 1852 FVELSTTSHGSPSSTPTTHFSASSTTLGRSEE----STTVHSSPVATATT-----PSPAR 1902

Query: 995  RMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHS--- 1051
              T G   +        ++ +H  P S      P     S T +GR   +    S +   
Sbjct: 1903 STTSGLVEE--------STAYHSSPGSTQTMHFPE----SSTASGRSEESRTSHSSTTHT 1950

Query: 1052 -SSDPYTASSRGMLPTALQNQ-DEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPK 1109
             SS P T S+    PT+  +     A   + D ST     +    +H+++       LP 
Sbjct: 1951 ISSPPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPA 2010

Query: 1110 HQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPS------ 1163
                    G               S   P   G  ++ A   S   PG SE  +      
Sbjct: 2011 RSTTSVLLG--------------ESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSP 2056

Query: 1164 KRPLSSKSQQSVSAED-DEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKE 1222
            + P ++ S  S ++    EE      + G     S+    +P S+T  G       L++ 
Sbjct: 2057 RSPATTLSPASTTSSGVSEESTTSHSRPG-----STHTTAFPDSTTTPG-------LSRH 2104

Query: 1223 EREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYT 1282
                  +      +L P       P   S   SH        + +  S  A +      T
Sbjct: 2105 STTSHSSPGSTDTTLLPASTTTSGPSQES-TTSHSSPGSTDTALSPGSTTALSFGQESTT 2163

Query: 1283 TRAPPGHFSTT--PMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNG 1340
              + PG   TT  P  +    ++ A  R   S    R +     +  P ++G+       
Sbjct: 2164 FHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGE-STAFQT 2222

Query: 1341 KPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIV-----DL 1395
             P        P  T     ++     +        +H        G   ++ +     D 
Sbjct: 2223 HPASTHTTPSPPSTA-TAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDA 2281

Query: 1396 EGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLV-GLEVIKKTTH----PPTTT 1450
             GT   S       G+G   T   +     I +L G     GL     T +     PTTT
Sbjct: 2282 SGTTPSSAHS-TTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTT 2340

Query: 1451 MQPTTTTT--PLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTP 1508
            + P + T+      +TT R    +T  T +   TTT  P  +  +TT  +++   T TT 
Sbjct: 2341 LSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTT--PGLSEESTTVYSSSPGSTETTV 2398

Query: 1509 IPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFE 1568
             P  P  ++   +        ++     + E+   SGL       TEE+          +
Sbjct: 2399 FPRTPTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGL-------TEESTAFPGSPASTQ 2451

Query: 1569 TSRPPTTT-----EPSTT 1581
            T  P T T     E STT
Sbjct: 2452 TGLPATLTTADLGEESTT 2469



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 274/1347 (20%), Positives = 410/1347 (30%), Gaps = 240/1347 (17%)

Query: 347  STSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPF 406
            ST+V+  +P S  TT         V G+      S  A   T       + +        
Sbjct: 2857 STTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPASTHTT------LFTEDSTTSGL 2910

Query: 407  GAKSLTYPGDTTSALVDGLQPGERYLFKIRAT-NRRGLGPHSKAFIVAMPTTSKADVEQN 465
              +S  +PG   S      Q G      + AT     LG  S  F  +  +T        
Sbjct: 2911 TEESTAFPGSPAST-----QTG------LPATLTTADLGEESTTFPSSSGSTGTTLSPAR 2959

Query: 466  TEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQL 525
            +  +G   +  PS  SP +  ++  P  P +P           L  K      +PR P  
Sbjct: 2960 STTSGLVGESTPSRLSPSSTETTTLPGSPTTPS----------LSEKSTTFYTSPRSPDA 3009

Query: 526  RAKKAEELDLQSTE--ITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHG-----HSVVA 578
                A       +E   T   + GS   +   P  T     +  P + H       + ++
Sbjct: 3010 TLSPATTTSSGVSEESSTSHSQPGSTHTTAF-PDSTTTSGLSQEPTASHSSQGSTEATLS 3068

Query: 579  PGRTAVRARMPALPRREGV--DKPGFSLATQPRPGAPPSA--SASPAHHASTQGTSHRPS 634
            PG T   +    L ++       PG +  T        S    AS   H+ST G+ H   
Sbjct: 3069 PGSTTASS----LGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSST-GSLHTTL 3123

Query: 635  LPASLNDNDLVDSDEDERAVGSLH-----PKGAFAQPRPALSPSRQSPSSVLRDRSSVHP 689
             PAS     L +     ++  S       P G  A P    +     PSS      S   
Sbjct: 3124 TPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASS 3183

Query: 690  GAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLL--PTQPHLSSPLSKGGKDG 747
                 S    T HS       S  A  + L P    +S L+  PT    +SP+S G  + 
Sbjct: 3184 TTLGRSEESTTVHS-------SPGATGTALFPTRSATSVLVGEPT----TSPISSGSTET 3232

Query: 748  EDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQT 807
               P + + A      ++  SS  S  T +S  +  S G S             E+T  T
Sbjct: 3233 TALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSE------------EST--T 3278

Query: 808  LRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDS 867
              +RP S H                S  S         + SP ST  S   P   +    
Sbjct: 3279 SHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSG 3338

Query: 868  HPKLSSGIHGDE-------EDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLH 920
                 + +  D        E   P+ ++  + H   S     +R  E    S    +  +
Sbjct: 3339 PGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGE----STTFQSWPN 3394

Query: 921  RKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPAR 980
             K+  P  P +T A            S       S  + T G S +    ST  H+SP  
Sbjct: 3395 SKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEE----STTVHSSPVA 3450

Query: 981  PPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGR 1040
                     PS  R  T G   +        ++ +H  P S      P     S T +GR
Sbjct: 3451 TATT-----PSPARSTTSGLVEE--------STTYHSSPGSTQTMHFPE----SDTTSGR 3493

Query: 1041 PRPTSQGRSHS----SSDPYTASSRGMLPTALQNQD-EDAQGSYDDDSTEVEAQDVRAPA 1095
               ++   S +    SS P T S+    PT+  +     A   + D ST     +    +
Sbjct: 3494 GEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTAS 3553

Query: 1096 HAARAKEAAASLPKH--------QQVESPTGAGA-------------GGDHRSQRGHAA- 1133
            H+++       LP          +   SP  +G+             G   +S   H++ 
Sbjct: 3554 HSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSP 3613

Query: 1134 -------SPARP-------------SRPGGPQSRARVPSRAAPG--------KSEPPSKR 1165
                   SPA               SRPG   + A   S   PG         S P S  
Sbjct: 3614 RSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTD 3673

Query: 1166 PLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEERE 1225
                 +  + S    E   +    G  +  LS      P S+T         +       
Sbjct: 3674 TTLLPASTTTSGSSQESTTSHSSSGSTDTALS------PGSTTALSFGQESTTFHSSPGS 3727

Query: 1226 PAIALAPRGGSLAPVKRPLPPPPGS--SPRASHVPSRLPPRSAATVSPVAGTHPWPQYTT 1283
                L P   + + +         S  SPR +  P+          S    THP   +TT
Sbjct: 3728 THTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTT 3787

Query: 1284 RAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPN 1343
             +PP   + T  +        +    P +  PA  S   G++ +  +       S   P+
Sbjct: 3788 PSPPS--TATAPVEESTTYHRSPGSTPTTHFPA-SSTTSGHSEKSTIFHSSPDASGTTPS 3844

Query: 1344 GQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSP 1403
                    +G      +  G                        +  T+     TP +S 
Sbjct: 3845 SAHSTTSGRGESTTSRISPG----------------------STEITTLPGSTTTPGLSE 3882

Query: 1404 DGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTT--TMQPTTTTTP-- 1459
                 +   R  +P        + SLG    VG E     + P +T  T+ P +TTTP  
Sbjct: 3883 ASTTFYSSPR--SPTTTLSPASMTSLG----VGEESTTSRSQPGSTHSTVSPASTTTPGL 3936

Query: 1460 --------------LPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTP 1505
                            TT  PR TT + RR   T   +    T T   T  +TT+     
Sbjct: 3937 SEESTTVYSSSPGSTETTVFPRSTTTSVRREEPTTFHSRPASTHTTLFTEDSTTSGLTEE 3996

Query: 1506 TTPIPTCP-------PGTLERHD--DDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            +T  P  P       P TL   D  ++     SS+G           +G +   A  T  
Sbjct: 3997 STAFPGSPASTQTGLPATLTTADLGEESTTFPSSSG----------STGTKLSPARSTTS 4046

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTAT 1583
              V          S   TTT P +  T
Sbjct: 4047 GLVGESTPSRLSPSSTETTTLPGSPTT 4073



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 257/1305 (19%), Positives = 411/1305 (31%), Gaps = 216/1305 (16%)

Query: 401  PALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKA 460
            P +      S + PG T + L  G             T    LGP S  F  +   T   
Sbjct: 330  PGVSQESTASHSIPGSTDTTLSPG------------TTTPSSLGPESTTFHSSPGYTKTT 377

Query: 461  DVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAP 520
             +  NT  +G  E   P   S  +P ++  PS   + +G                     
Sbjct: 378  RLPDNTTTSGLLEASTPVHSSTGSPHTTLSPSSSTTHEGEPTTFQSWPSSKDTSPAPSGT 437

Query: 521  RKPQLRAKKAEELDLQSTEIT----GEEELG-SREDSPMSPSDTQDQKRTLRPPSRHGHS 575
                ++          ST  T        LG S E +P+  S       T  PP+R   S
Sbjct: 438  TSAFVKLSTTYHSSPSSTPTTHFSASSTTLGHSEESTPVHSSPVATA--TTPPPARSATS 495

Query: 576  VVAPGRTAVRARMPALPRR----EGVDKPGFSLATQPRPGAPP-SASASPAHHASTQGTS 630
                  TA   R P   +     E     G S  +    G+   + S++P+  A+   TS
Sbjct: 496  GHVEESTAYH-RSPGSTQTMHFPESSTTSGHSEESATFHGSTTHTKSSTPSTTAALAHTS 554

Query: 631  HRPSLPAS----LNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSS 686
            +  SL ++      D+  +    +E       P        PA S    +PS ++ D + 
Sbjct: 555  YHSSLGSTETTHFRDSSTISGRSEESKASHSSPDAMATTVLPAGS----TPSVLVGDST- 609

Query: 687  VHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKD 746
              P    +     T   G+  +   +    +  S P        P   HL + ++  G  
Sbjct: 610  --PSPISSGSMETTALPGSTTKPGLSEKSTTFYSSPRS------PDTTHLPASMTSSGVS 661

Query: 747  GEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQ 806
             E++  ++S   S  T +   S+ +   +Q S  + +S G +  D     G   A +   
Sbjct: 662  -EESTTSHSRPGSTHTTAFPGSTTMPGLSQESTASHSSPGPT--DTTLSPGSTTASSLGP 718

Query: 807  ---TLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPS 863
               T  +RP S    LL     A+     S       P    + SP +T+        P+
Sbjct: 719  EYTTFHSRPGSTETTLLPDNTTASGLLEASM------PVHSSTRSPHTTLS-------PA 765

Query: 864  HSDSHPKLSSGIHG--DEEDEKPLPATVVNDHVPSSSRQ---PISRGWEDLRRSPQRGAS 918
             S +    S+  H     +D +P P T  +  V  S+     P S     +         
Sbjct: 766  GSTTRQGESTTFHSWPSSKDTRPAPPTTTSAFVEPSTTSHGSPSSIPTTHISARSTTSGL 825

Query: 919  LHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASP 978
            +        +P ST     P+   +S   +      S+   T   +P       +   S 
Sbjct: 826  VEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSY 885

Query: 979  ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQA 1038
               P + +  H       T GR+ +       +T+ H     S+DA  +   P  S T  
Sbjct: 886  HSSPGSTATTH-FPDSSTTSGRSEE-------STASH----SSQDATGTIVLPARSTTSV 933

Query: 1039 ----GRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAP 1094
                    P S G   +++ P + ++ G+                 + ST   +    +P
Sbjct: 934  LLGESTTSPISSGSMETTALPGSTTTPGL----------------SERSTTFHS----SP 973

Query: 1095 AHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRA 1154
               A     A++       ES T     G   +     A P   + PG   SR    S +
Sbjct: 974  RSPATTLSPASTTSSGVSEESTTSRSRPGSTHT----TAFPDSTTTPG--LSRHSTTSHS 1027

Query: 1155 APGKSEP---PSKRPLSSKSQQSVSAEDDE-EEDAGFFKG-------GKEDLLSSSVPK- 1202
            +PG ++    P+    S  SQ+S ++       D     G       G+E     S P  
Sbjct: 1028 SPGSTDTTLLPASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHSNPGS 1087

Query: 1203 -----WPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHV 1257
                 +P S+T  G  +A   +      P   L+P   S +P  +       + P ++H 
Sbjct: 1088 THTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSP-ASSTSPGLQGESTAFQTHPASTHT 1146

Query: 1258 PSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHF---STTPMLSLRQRMMH----ARFRNP 1310
                P  + A V      H  P  T   P  HF   STT   S +  + H    A    P
Sbjct: 1147 TPSPPSTATAPVEESTTYHRSPGST---PTTHFPASSTTSGHSEKSTIFHSSPDASGTTP 1203

Query: 1311 LSRQPARPSYRQGYNGR---PNVEGKVLPGSNGKPN----GQRIINGPQGTKWVVDLDRG 1363
             S         +    R    + E   LPGS   P          + P+     +     
Sbjct: 1204 SSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLS-PAS 1262

Query: 1364 LVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGT-PVVSPDGLPLFGQGRHGTPLANAQ 1422
            +     G     S   P     G    T+     T P +S +   ++   R  T      
Sbjct: 1263 MTSLGVGEESTTSRSQP-----GSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFP 1317

Query: 1423 DKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTT----------------TTTPLPTTTT- 1465
                 S+ G+          +TH    T   TT                T T LP T T 
Sbjct: 1318 HSTTTSVHGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTT 1377

Query: 1466 ----------PRPTTATTRRTTTTRRTTT---------RRPTTTVRTTTRTTTTTTP--- 1503
                      P  + +T  + +  R TT+         R   ++  TTT   + TTP   
Sbjct: 1378 ADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLS 1437

Query: 1504 --------TPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTE 1555
                    +P +P  T  P T            +S+G+ E  +      G    TA P  
Sbjct: 1438 EKSTTFYTSPRSPDATLSPAT-----------TTSSGVSEESSTSHSQPGSTHTTAFP-- 1484

Query: 1556 EAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEE 1600
                  D     + S+ PTT+  S  +T   + P     SS  ++
Sbjct: 1485 ------DSTTTSDLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQ 1523



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 270/1323 (20%), Positives = 430/1323 (32%), Gaps = 245/1323 (18%)

Query: 445  PHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKD 504
            P SK  + A PTT+ A VE +T  +G P     S+P+    ASS       +  GR+ + 
Sbjct: 1836 PSSKDTMPAPPTTTSAFVELSTTSHGSPS----STPTTHFSASS-------TTLGRSEES 1884

Query: 505  LLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDT----Q 560
              +       A   +P +        E     S+        GS +      S T     
Sbjct: 1885 TTVHSSPVATATTPSPARSTTSGLVEESTAYHSSP-------GSTQTMHFPESSTASGRS 1937

Query: 561  DQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASP 620
            ++ RT    + H  S   P  T+     P          PG S AT   P +  ++  S 
Sbjct: 1938 EESRTSHSSTTHTISS-PPSTTSALVEEPTSYH----SSPG-STATTHFPDSSTTSGRSE 1991

Query: 621  AHHAS--TQGTSHRPSLPASLNDNDLV-DSDEDERAVGSLHPKGAFAQPRPALSPSRQSP 677
               AS  +Q  +    LPA    + L+ +S     + GS+      A P    +P     
Sbjct: 1992 ESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETT---ALPGSTTTPGLSEK 2048

Query: 678  SSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLP--TQPH 735
            S+     SS    A   SPA  T  SG +EE +++ + P          S   P  ++  
Sbjct: 2049 STTFH--SSPRSPATTLSPASTTS-SGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHS 2105

Query: 736  LSSPLSKGGKDGEDAPA-TNSNAPSRSTMSS-----SVSSHLS--SRTQVSEGAEA---- 783
             +S  S G  D    PA T ++ PS+ + +S     S  + LS  S T +S G E+    
Sbjct: 2106 TTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFH 2165

Query: 784  -SDGESHG----DGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIG 838
             S G +H     D     G  +A     +    P +         P    G S +  +  
Sbjct: 2166 SSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSP-GLQGESTAFQTHP 2224

Query: 839  RGPRLQPSSSPQSTVP---SRAHPRVP-SHSDSHPKLSSGIHGDEEDEKPLPATV-VNDH 893
                  PS    +T P   S  + R P S   +H   SS   G  E      ++   +  
Sbjct: 2225 ASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGT 2284

Query: 894  VPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQ 953
             PSS+    S   E        G++      +P +  + G        YSS  S    + 
Sbjct: 2285 TPSSAHSTTSGRGESTTSRISPGST--EITTLPGSTTTPGLSEASTTFYSSPRSPTTTLS 2342

Query: 954  Q----STDADTEGHSPKAQPGSTDRHASPAR-----------------PPAARSQQHPSV 992
                 S     E  + ++QPGST    SPA                  P +  +   P  
Sbjct: 2343 PASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRT 2402

Query: 993  PRRMTPGRAPQQQPPPPVAT-----------------SQHHPG-PQSRDAGRSPSQPRLS 1034
            P     G  P      P +T                 S   PG P S   G   +     
Sbjct: 2403 PTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTAD 2462

Query: 1035 LTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQ--DVR 1092
            L +     P+S G + ++  P  +++ G++        E         STE         
Sbjct: 2463 LGEESTTFPSSSGSTGTTLSPARSTTSGLV-------GESTPSRLSPSSTETTTLPGSPT 2515

Query: 1093 APAHAARAKEAAASLPKHQQVESP-TGAGAGGDHRSQRGHA--------ASPARPSRPGG 1143
             P+ + ++     S        SP T   +G    S   H+        A P   + PG 
Sbjct: 2516 TPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTPG- 2574

Query: 1144 PQSRARVPSRAAPGKSEP---PSKRPLSSKSQQSVSAEDDE-EEDAGFFKG-------GK 1192
              SR    S ++PG ++    P+    S  SQ+S ++       D     G       G+
Sbjct: 2575 -LSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQ 2633

Query: 1193 EDLLSSSVPK------WPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVK----- 1241
            E     S P       +P S+T  G  +A   +      P   L+P   +   ++     
Sbjct: 2634 ESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTT 2693

Query: 1242 ----------RPLPPP---------------PGSSPRASHVPSRLPPRSAATVSPV---- 1272
                       P PP                PGS+P  +H P+       +  S +    
Sbjct: 2694 FQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTP-TTHFPASSTTSGHSEKSTIFHSS 2752

Query: 1273 ---AGTHPWPQYTT----------RAPPGHF--------STTPMLSLRQRMMHARFRNPL 1311
               +GT P   ++T          R  PG          +TTP LS      ++  R+P 
Sbjct: 2753 PDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPT 2812

Query: 1312 SRQPARPSYRQGYNGRPNVEGKVLPGSNGKP-------------NGQRIINGPQGTKWVV 1358
            +          G  G  +   +  PGS                     + +   G+    
Sbjct: 2813 TTLSPASMTSLGV-GEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETT 2871

Query: 1359 DLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPL 1418
               R    +  G      H  P          T +  E +   +  GL        G+P 
Sbjct: 2872 VFPRSTTTSVRGEEPTTFHSRP------ASTHTTLFTEDS---TTSGLTEESTAFPGSPA 2922

Query: 1419 ANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTT 1478
            +     P        L   ++ +++T  P+++    TT +P  +TT+     +T  R + 
Sbjct: 2923 STQTGLPAT------LTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSP 2976

Query: 1479 TRRTTTRRP-TTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECY 1537
            +   TT  P + T  + +  +TT   +P +P  T  P T            +S+G+ E  
Sbjct: 2977 SSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPAT-----------TTSSGVSEES 3025

Query: 1538 AEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSF 1597
            +      G    TA P        D       S+ PT +  S  +T   + P     SS 
Sbjct: 3026 STSHSQPGSTHTTAFP--------DSTTTSGLSQEPTASHSSQGSTEATLSPGSTTASSL 3077

Query: 1598 PEE 1600
             ++
Sbjct: 3078 GQQ 3080



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 291/1397 (20%), Positives = 444/1397 (31%), Gaps = 246/1397 (17%)

Query: 348  TSVFQRTPESAPTTA-PENLNVWPVNGKPTVVAASWDALPETEGKVKEYIL----SYAPA 402
            ++ + R+P S PTT  P +      + K T+  +S DA   T             S    
Sbjct: 2244 STTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSR 2303

Query: 403  LKPFGAKSLTYPGDTTS-----------------------ALVDGLQPGERYLFKIRATN 439
            + P   +  T PG TT+                       A +  L  GE        T+
Sbjct: 2304 ISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEE-----STTS 2358

Query: 440  RRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQG 499
            R   G        A  TT     E  T  +  P   E ++  PR P +S     P +   
Sbjct: 2359 RSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTE-TTVFPRTPTTSVRGEEPTTFHS 2417

Query: 500  RNAKDLLLDLKNKILANGGAPRKPQLRAKKAE-ELDLQSTEITGEEELGSREDSPMSPSD 558
            R A             +G            A  +  L +T  T +  LG  E+S   PS 
Sbjct: 2418 RPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTAD--LG--EESTTFPSS 2473

Query: 559  TQDQKRTLRPPSRHGHSVVA---PGRTAVRAR----MPALPRREGVDKPGFSLATQPRPG 611
            +     TL P       +V    P R +  +     +P  P    + +   +  T PR  
Sbjct: 2474 SGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRS- 2532

Query: 612  APPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALS 671
              P A+ SPA   S+ G S               +S       GS H   AF        
Sbjct: 2533 --PDATLSPATTTSS-GVSE--------------ESSTSHSQPGSTHTT-AFPDSTTTPG 2574

Query: 672  PSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLP 731
             SR S +S      S      PAS     P   +    SS  +  + LSP  G ++ L  
Sbjct: 2575 LSRHSTTSH-SSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSP--GSTTALSF 2631

Query: 732  TQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGD 791
             Q   +   S G       P + +++      +   SS  S RT +S  +  S G     
Sbjct: 2632 GQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPG----- 2686

Query: 792  GDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSS---S 848
                    Q E+T  T +  PAS H              +PS  S    P  + ++   S
Sbjct: 2687 -------LQGEST--TFQTHPASTH-------------TTPSPPSTATAPVEESTTYHRS 2724

Query: 849  PQSTVPSRAHPRVPSHSDSHPKLSSGIHG--DEEDEKPLPATVVNDHVPSSSRQPISRGW 906
            P ST  +  H    S +  H + S+  H   D     P  A         S+   IS G 
Sbjct: 2725 PGSTPTT--HFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGS 2782

Query: 907  EDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPK 966
             ++   P    +    E       ST   + P+   ++L+  +     S     E  + +
Sbjct: 2783 TEITTLPGSTTTPGLSEA------STTFYSSPRSPTTTLSPASMT---SLGVGEESTTSR 2833

Query: 967  AQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATS-------QHHPGP 1019
            +QPGST    SPA        +  +     +PG       P    TS         H  P
Sbjct: 2834 SQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRP 2893

Query: 1020 QS----------------RDAGRSPSQPRLSLTQAGRPR--------------PTSQGRS 1049
             S                 ++   P  P  + TQ G P               P+S G +
Sbjct: 2894 ASTHTTLFTEDSTTSGLTEESTAFPGSP--ASTQTGLPATLTTADLGEESTTFPSSSGST 2951

Query: 1050 HSSSDPYTASSRGML--PTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASL 1107
             ++  P  +++ G++   T  +      + +    S    +   ++       +   A+L
Sbjct: 2952 GTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATL 3011

Query: 1108 PKHQQVESPTGAGAGGDHRSQRGHAASPARP-SRPGGPQSRARVPSRAAPGKSE---PPS 1163
                   S     +   H SQ G   + A P S      S+    S ++ G +E    P 
Sbjct: 3012 SPATTTSSGVSEESSTSH-SQPGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSPG 3070

Query: 1164 KRPLSSKSQQSV---SAEDDEEEDAGFFKGGKEDLLSSSVPK-----------WPSSSTP 1209
                SS  QQS    S+  D E            L+ +S P             P+SST 
Sbjct: 3071 STTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTS 3130

Query: 1210 RGGKDADGSLAKEEREPAIALAPRGGSLAPVK-------RPLPPPP----------GSSP 1252
             G ++   +            +P G + APV+       RP   P           G S 
Sbjct: 3131 AGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSE 3190

Query: 1253 RASHVPSR--------LPPRSAATV---SPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQR 1301
             ++ V S          P RSA +V    P           T A PG  +TT  LS +  
Sbjct: 3191 ESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGS-TTTAGLSEKST 3249

Query: 1302 MMHARFRNPLSRQPARPSYRQGY-------NGRP-NVEGKVLPGSNGKPNGQRIINGPQG 1353
              ++  R+P +      +   G        + RP +      PGS   P   +       
Sbjct: 3250 TFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHS 3309

Query: 1354 TKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGT--PVVSPDGLPLFGQ 1411
            +    D                S G+     LG +  T     G+    + PD     G 
Sbjct: 3310 SPGSTDTTL-------------SPGSTTASSLGPESTTFHSGPGSTETTLLPDNTTASGL 3356

Query: 1412 GRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQP---TTTTTPLPTTTTPR- 1467
                TP+ ++   P  +L             T    +TT Q    +  TTP P TTT   
Sbjct: 3357 LEASTPVHSSTGSPHTTLS-------PAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAF 3409

Query: 1468 ---PTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDG 1524
                TT+    ++T     +   TT  R+   TT  ++P  T   P+    T     ++ 
Sbjct: 3410 VELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEES 3469

Query: 1525 NLIMSSNGIPEC--YAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTA 1582
                SS G  +   + E D  SG         EE+   +       +S P TT+      
Sbjct: 3470 TTYHSSPGSTQTMHFPESDTTSG-------RGEESTTSHSSTTHTISSAPSTTSALVEEP 3522

Query: 1583 TTPRVIPEEGAISSFPE 1599
            T+    P   A + FP+
Sbjct: 3523 TSYHSSPGSTATTHFPD 3539



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 180/901 (19%), Positives = 281/901 (31%), Gaps = 124/901 (13%)

Query: 456  TTSKADVEQNTEDNGKPEKPEPSS--PSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKI 513
            TTS    E++T    +P     ++   S   P  S+H +   S  G     LL       
Sbjct: 985  TTSSGVSEESTTSRSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLL------- 1037

Query: 514  LANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQ-----DQKRTLRP 568
                            +      S E T         D+ +SP  T       +  T   
Sbjct: 1038 --------------PASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHS 1083

Query: 569  PSRHGHSVVAPGRTAVRARMPALPR---REGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
                 H+ + P  T     + A  R     G  +   S A+   PG    ++A   H AS
Sbjct: 1084 NPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPAS 1143

Query: 626  TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRS 685
            T  T   PS   +     + +S    R+ GS           P       S +S   ++S
Sbjct: 1144 THTTPSPPSTATA----PVEESTTYHRSPGS----------TPTTHFPASSTTSGHSEKS 1189

Query: 686  SVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSP-LSKGG 744
            ++   +  AS    TP S  +       +  SR+SP   GS+ +       ++P LS+  
Sbjct: 1190 TIFHSSPDASGT--TPSSAHSTTSGRGESTTSRISP---GSTEITTLPGSTTTPGLSEAS 1244

Query: 745  KDGEDAPATNSNAPSRSTMSS---------SVSSHLSSRTQVSEGAEASDGESHGDGDRE 795
                 +P + +   S ++M+S         S S   S+ + VS  +  + G S       
Sbjct: 1245 TTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVY 1304

Query: 796  DGGRQAEATA---------------QTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRG 840
               R +  T                 T  +RPAS H  L       +     S    G  
Sbjct: 1305 SSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPG-- 1362

Query: 841  PRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ 900
                P+S+      +     +   S + P  S          +   + +V +  P S   
Sbjct: 1363 ---SPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGESTP-SRLS 1418

Query: 901  PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADT 960
            P S     L  SP   +   +      +P+S  A   P    SS  S+            
Sbjct: 1419 PSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSE------------ 1466

Query: 961  EGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATS------Q 1014
            E  +  +QPGST   A P     +   Q P+              P    A+S       
Sbjct: 1467 ESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQSTT 1526

Query: 1015 HHPGPQSRDAGRSPSQPRLS-LTQAGRPRPTSQGRSHSSSDPYTASSRGML--PTALQNQ 1071
             H  P   +    P     S L +A  P  +S G  H++  P +++S G+    T  Q+ 
Sbjct: 1527 FHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSAGLQEESTTFQSW 1586

Query: 1072 DEDAQGSYDDDSTEVEAQDVRAPAHAARAKE-----AAASLPKHQQVESPT---GAGAGG 1123
               +  +     T     +V    H+  +       +A+S    +  ES T     GA G
Sbjct: 1587 PSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGATG 1646

Query: 1124 DHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEE 1183
                    A S         P S     + A PG +        S+    S  + D    
Sbjct: 1647 TALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLS 1706

Query: 1184 DAGFFKGG--KEDLLSSSVP------KWPSSSTPRGGKDADGSLAKEEREPAIALAP--- 1232
             A     G  +E   S S P       +P S+T  G      +           L+P   
Sbjct: 1707 PASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDTTLSPGST 1766

Query: 1233 RGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFST 1292
               SL P        PGS+   + +P           S    +     +TT +P G  ST
Sbjct: 1767 TASSLGPESTTFHSSPGST-ETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAG--ST 1823

Query: 1293 T 1293
            T
Sbjct: 1824 T 1824



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 196/936 (20%), Positives = 299/936 (31%), Gaps = 144/936 (15%)

Query: 702  HSGAAEEDSSASAPP----SRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNA 757
            +SG +EE + + + P    + L P H  +S +   +P  +SP++    +    P + + A
Sbjct: 217  NSGHSEESTVSHSGPGATGTTLFPSHSATS-VFVGEPK-TSPITSASMETTALPGSTTTA 274

Query: 758  PSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHF 817
                  ++  SS  S    +S     S G S                + T  +RP   H 
Sbjct: 275  GLSEKSTTFYSSPRSPDRTLSPARTTSSGVSE--------------KSTTSHSRPGPTHT 320

Query: 818  HLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHG 877
                           S  S         + SP +T PS   P   +   S         G
Sbjct: 321  IAFPDSTTMPGVSQESTASHSIPGSTDTTLSPGTTTPSSLGPESTTFHSSP--------G 372

Query: 878  DEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTH 937
              +  +    T  +  + +S+    S G      SP   ++ H  EP       +  DT 
Sbjct: 373  YTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSPS-SSTTHEGEPTTFQSWPSSKDTS 431

Query: 938  PQGK------------YSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAAR 985
            P               Y S  S       S  + T GHS ++ P  +   A+   PP AR
Sbjct: 432  PAPSGTTSAFVKLSTTYHSSPSSTPTTHFSASSTTLGHSEESTPVHSSPVATATTPPPAR 491

Query: 986  S----QQHPSVPRRMTPGRAPQQQPPPPVATSQHHP------GPQSRDAGRSPS------ 1029
            S        S     +PG       P    TS H        G  +     +PS      
Sbjct: 492  SATSGHVEESTAYHRSPGSTQTMHFPESSTTSGHSEESATFHGSTTHTKSSTPSTTAALA 551

Query: 1030 ----QPRLSLTQAG--RPRPTSQGR------SHSSSDPY--TASSRGMLPTALQNQDEDA 1075
                   L  T+    R   T  GR      SHSS D    T    G  P+ L    +  
Sbjct: 552  HTSYHSSLGSTETTHFRDSSTISGRSEESKASHSSPDAMATTVLPAGSTPSVLVG--DST 609

Query: 1076 QGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASP 1135
                   S E  A     P    +   +  S   +    SP          S      S 
Sbjct: 610  PSPISSGSMETTA----LPGSTTKPGLSEKSTTFYSSPRSPDTTHLPASMTSSGVSEEST 665

Query: 1136 ARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLS------SKSQQSVSAEDDEEEDAGFFK 1189
               SRPG   + A   S   PG S+  +    S      + S  S +A     E   F  
Sbjct: 666  TSHSRPGSTHTTAFPGSTTMPGLSQESTASHSSPGPTDTTLSPGSTTASSLGPEYTTFHS 725

Query: 1190 --GGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPP 1247
              G  E  L       P ++T  G  +A   +    R P   L+P G +    ++     
Sbjct: 726  RPGSTETTL------LPDNTTASGLLEASMPVHSSTRSPHTTLSPAGST---TRQGESTT 776

Query: 1248 PGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARF 1307
              S P +       P  ++A V P   +H  P           STT  L       H+  
Sbjct: 777  FHSWPSSKDTRPAPPTTTSAFVEPSTTSHGSPSSIPTTHISARSTTSGLVEESTTYHS-- 834

Query: 1308 RNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLN 1367
             +P S Q          +GR    G+    S+       I + P  T  +V+        
Sbjct: 835  -SPGSTQTMHFPESDTTSGR----GEESTTSHSSTT-HTISSAPSTTSALVEEPTSY--- 885

Query: 1368 AEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKP-I 1426
                     H +P     G    T           PD     G+    T   ++QD    
Sbjct: 886  ---------HSSP-----GSTATTHF---------PDSSTTSGRSEESTASHSSQDATGT 922

Query: 1427 LSLGGKPLVGLEVIKKTTHPPT-----TTMQPTTTTTP-LPTTTTPRPTTATTRRTTTTR 1480
            + L  +    + + + TT P +     TT  P +TTTP L   +T   ++  +  TT + 
Sbjct: 923  IVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPATTLSP 982

Query: 1481 RTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEE 1540
             +TT    +   TT+R+   +T T   P  T  PG L RH    +   SS G     + +
Sbjct: 983  ASTTSSGVSEESTTSRSRPGSTHTTAFPDSTTTPG-LSRHSTTSH---SSPG-----STD 1033

Query: 1541 DEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTT 1576
                   T T+ P++E+   +      +T+  P +T
Sbjct: 1034 TTLLPASTTTSGPSQESTTSHSSSGSTDTALSPGST 1069



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 277/1325 (20%), Positives = 418/1325 (31%), Gaps = 242/1325 (18%)

Query: 478  SSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQS 537
            S+PS  +P+S++  ++P SP   +       L  K      +PR P      A      +
Sbjct: 2495 STPSRLSPSSTETTTLPGSPTTPS-------LSEKSTTFYTSPRSPDATLSPAT-----T 2542

Query: 538  TEITGEEELGSREDSPMSPSDTQDQKRTLRPP-SRHGH-SVVAPGRTAVRARMPALPRRE 595
            T     EE  +    P S   T     T  P  SRH   S  +PG T     +PA     
Sbjct: 2543 TSSGVSEESSTSHSQPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTL-LPASTTTS 2601

Query: 596  GVDKPGFSLATQP-------RPGAPPSAS---ASPAHHASTQGTSHRPSLPASLNDNDLV 645
            G  +   +  + P        PG+  + S    S   H+S  G++H    P S   + +V
Sbjct: 2602 GPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSP-GSTHTTLFPDSTTSSGIV 2660

Query: 646  DSD------------------------EDERAVGSLHPKGAFAQPRPALSPSRQSPSSVL 681
            ++                         + E      HP      P P  + +     S  
Sbjct: 2661 EASTRVHSSTGSPRTTLSPASSTSPGLQGESTTFQTHPASTHTTPSPPSTATAPVEESTT 2720

Query: 682  RDRSSVHPGAKPAS--PARRTPHSGAAEE--------DSSASAPPSRLSPPHGG----SS 727
              RS   PG+ P +  PA  T  SG +E+        D+S + P S  S   G     +S
Sbjct: 2721 YHRS---PGSTPTTHFPASSTT-SGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTS 2776

Query: 728  RLLPTQPHLSS-PLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLS---------SRTQ- 776
            R+ P    +++ P S       +A  T  ++P   T + S +S  S         SR+Q 
Sbjct: 2777 RISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQP 2836

Query: 777  ----------------VSEGAEASDGESHGDGDREDGGRQAEATAQ-----TLRARPASG 815
                            +SE +      S G  +     R    + +     T  +RPAS 
Sbjct: 2837 GSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPAST 2896

Query: 816  HFHLLRH--------KPFAANGRSPSRFSIGRGPRLQPSS--SPQSTVPSRAHPRVPSHS 865
            H  L           +   A   SP+    G    L  +      +T PS +     + S
Sbjct: 2897 HTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLS 2956

Query: 866  DSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPI----SRGWEDLRRSPQ------- 914
             +    +SG+ G+    +  P++     +P S   P     S  +    RSP        
Sbjct: 2957 PAR-STTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPAT 3015

Query: 915  -------RGASLHRKEP-------IPENPKSTGADTHPQGKYSSLASKAQDVQQ-STDAD 959
                     +S    +P        P++  ++G    P   +SS  S    +   ST A 
Sbjct: 3016 TTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSPGSTTAS 3075

Query: 960  TEGHSPK---AQPGSTDRHASP----------ARPPAARSQQHPSVPRRMTPGRAPQQQP 1006
            + G       + PG T+    P          A  P   S    S+   +TP  +     
Sbjct: 3076 SLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTG--SLHTTLTPASSTSAGL 3133

Query: 1007 PPPVATSQHHPGPQSRDA---GRSPSQPRLSLTQAGRPRPT----------SQGRSHSSS 1053
                 T Q  P          G + +   +S T   RP  T          + GRS  S+
Sbjct: 3134 QEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEEST 3193

Query: 1054 DPYT---ASSRGMLPTALQNQ---DEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASL 1107
              ++   A+   + PT         E         STE  A     P     A  +  S 
Sbjct: 3194 TVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTA----LPGSTTTAGLSEKST 3249

Query: 1108 PKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPL 1167
              +    SP    +     S      S    SRPG   + A   S   PG S+  +    
Sbjct: 3250 TFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHS 3309

Query: 1168 SSKSQQ------SVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAK 1221
            S  S        S +A     E   F  G      S+     P ++T  G  +A   +  
Sbjct: 3310 SPGSTDTTLSPGSTTASSLGPESTTFHSGPG----STETTLLPDNTTASGLLEASTPVHS 3365

Query: 1222 EEREPAIALAPRGGSLA----------PVKRPLPPPPGSSPRA-------SH-VPSRLPP 1263
                P   L+P G +            P  +   P P ++  A       SH  PS  P 
Sbjct: 3366 STGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPT 3425

Query: 1264 RSAATVSPVAG-------THPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPA 1316
               +  S   G        H  P  T   P    STT  L       H+   +P S Q  
Sbjct: 3426 THFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHS---SPGSTQTM 3482

Query: 1317 RPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGR---YL 1373
                    +GR    G+    S+       I + P  T  +V+       +       + 
Sbjct: 3483 HFPESDTTSGR----GEESTTSHSSTT-HTISSAPSTTSALVEEPTSYHSSPGSTATTHF 3537

Query: 1374 QDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGT-PLANAQDKPILSLGGK 1432
             DS     R +      +  D  GT V+          G   T P+++   +     G  
Sbjct: 3538 PDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGST 3597

Query: 1433 PLVGLEVIKKTTHP----PTTTMQPTTTTTP----LPTTTTPRP--TTATTRRTTTTRRT 1482
               GL     T H     P TT+ P +TT+       TT+  RP  T  T    +TT   
Sbjct: 3598 TTPGLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPG 3657

Query: 1483 TTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDE 1542
             +R  TT+  +   T TT  P  TT   +    T             S G     +   E
Sbjct: 3658 LSRHSTTSHSSPGSTDTTLLPASTTTSGSSQESTTSHSSSGSTDTALSPGSTTALSFGQE 3717

Query: 1543 FS------GLETDTAVP---TEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGA 1593
             +      G    T  P   T    V         T  P TT  P+ ++T+P +  E  A
Sbjct: 3718 STTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPA-SSTSPGLQGESTA 3776

Query: 1594 ISSFP 1598
              + P
Sbjct: 3777 FQTHP 3781



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 145/708 (20%), Positives = 234/708 (33%), Gaps = 117/708 (16%)

Query: 410  SLTYPGDTTSALVDGLQPGER-YLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTED 468
            S T PG +  +      PG         +T    LGP S  F  +  +T    +  NT  
Sbjct: 4377 STTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTA 4436

Query: 469  NGKPEKPEPSSPSPRAPASSQHPSVPASPQGR--------NAKD----------LLLDLK 510
            +G  E   P   S  +P ++  P+   + QG         N+KD            ++L 
Sbjct: 4437 SGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELS 4496

Query: 511  NKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRT----L 566
                 + G+P      +         ST +   EE  +   SP++ + T    R+    L
Sbjct: 4497 T---TSHGSP-----SSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGL 4548

Query: 567  RPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASA---SPAHH 623
               S   HS     +T           R        S  T     AP + SA    P  +
Sbjct: 4549 VEESTTYHSSPGSTQTMHFPESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSY 4608

Query: 624  ASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRD 683
             S+ G++     P S   +    S+E   +  S    G    P        +S +SVL  
Sbjct: 4609 HSSPGSTATTHFPDSSTTSG--RSEESTASHSSQDATGTIVLP-------ARSTTSVLLG 4659

Query: 684  RSSVHPGAKPASPARRTPHS----GAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSP 739
             S+  P +  +      P S    G +E+ ++  + PS     H  +S         S+ 
Sbjct: 4660 ESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPSSTPTTHFSAS---------STT 4710

Query: 740  LSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDG---------ESHG 790
            L +     E++   +S+  + +T  S   S  S   + S    +S G          S  
Sbjct: 4711 LGR----SEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTA 4766

Query: 791  DGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQ 850
             G  E+      +T  T+ + P++           +A    P+ +    G          
Sbjct: 4767 SGRSEESRTSHSSTTHTISSPPST----------TSALVEEPTSYHSSPGSIATTHFPES 4816

Query: 851  STVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPA-TVVNDHVPSSSRQPISRG-WED 908
            ST   R+     SHS            D     PLPA    +  +  S+   IS G  E 
Sbjct: 4817 STTSGRSEESTASHSSP----------DTNGITPLPAHFTTSGRIAESTTFYISPGSMET 4866

Query: 909  LRRSPQRGASLHRKEPI-------PENPKSTGADTHP--QGKYSSLASKAQDVQQS---T 956
               S      L  K  I       P+   S  + T     G+ +SL S+A+    +    
Sbjct: 4867 TLASTATTPGLSAKSTILYSSSRSPDQTLSPASMTSSSISGEPTSLYSQAESTHTTAFPA 4926

Query: 957  DADTEGHSPK-----AQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVA 1011
               T G S +     ++PGST+   SP     +   Q  + P    PG A     P    
Sbjct: 4927 STTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFAQEFTTPHSQ-PGSALSTVSPASTT 4985

Query: 1012 -------TSQHHPGPQSRDAGRSPSQPRLSL-TQAGRPRPTSQGRSHS 1051
                   ++  +  P S +         +S+ +Q   P P S G +H+
Sbjct: 4986 VPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTPFPDSPGFTHT 5033



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 47/189 (24%), Positives = 73/189 (38%), Gaps = 18/189 (9%)

Query: 1448 TTTMQPTTTTTPLPTTTTP-RPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPT 1506
            TT +   TT + L   +TP   +T +   T +   +TTR+  +T   +   +  TTP P 
Sbjct: 3344 TTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAP- 3402

Query: 1507 TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYE 1566
               PT     +E       L  +S+G P        FS   T T   +EE+  ++     
Sbjct: 3403 ---PTTTSAFVE-------LSTTSHGSPSS-TPTTHFSASST-TLGRSEESTTVHSSPVA 3450

Query: 1567 FETSRPP---TTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPS 1623
              T+  P   TT+     +TT    P       FPE +      +     + +  +   S
Sbjct: 3451 TATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISS 3510

Query: 1624 APCSLTDAL 1632
            AP S T AL
Sbjct: 3511 AP-STTSAL 3518



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 47/189 (24%), Positives = 72/189 (38%), Gaps = 18/189 (9%)

Query: 1448 TTTMQPTTTTTPLPTTTTP-RPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPT 1506
            TT +   TT + L   +TP   +T +   T +   +TTR+  +T   +   +  TTP P 
Sbjct: 4427 TTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAP- 4485

Query: 1507 TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYE 1566
               PT     +E       L  +S+G P        FS   T T   +EE+  ++     
Sbjct: 4486 ---PTTTSAFVE-------LSTTSHGSPSS-TPTTHFSASST-TLGRSEESTTVHSSPVA 4533

Query: 1567 FETSRPP---TTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPS 1623
              T+  P   TT+     +TT    P       FPE        +     + +  +   S
Sbjct: 4534 TATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRGEESTTSHSSTTHTISS 4593

Query: 1624 APCSLTDAL 1632
            AP S T AL
Sbjct: 4594 AP-STTSAL 4601


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 169/776 (21%), Positives = 254/776 (32%), Gaps = 122/776 (15%)

Query: 499  GRNAKDLLLDLKNKILAN----GGAP------RKPQLRAKKAEELDLQSTEITGE----- 543
            G+NA++ + +L   +L+      G P      +K +++ ++ E+  L S +   E     
Sbjct: 95   GKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKR 154

Query: 544  ---EELGSREDSPMSPSDTQDQKRTLRPPSR---------HGHSVVAPGRTAVRARMPAL 591
               E+  SRE    S S  + + R+  P  R           HS     RT  R+  PA 
Sbjct: 155  DKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAP 214

Query: 592  PRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDE 651
             ++E   +          P    + S S             P  P S   N   + ++++
Sbjct: 215  EKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEP-SPEKNSKKEKEKEK 273

Query: 652  RAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSS 711
                S     + ++ R + SPS   P    R RS  +   +  SP RR            
Sbjct: 274  TRPRSRSRSKSRSRTR-SRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRP--------SPR 324

Query: 712  ASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHL 771
               PP R+ PP        P +    S  S  G     + + + + P +    +S     
Sbjct: 325  RRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRK 384

Query: 772  SSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRAR-------PASGHFHLLRHKP 824
            + R   S                    R +    Q+ R R       P      + +HK 
Sbjct: 385  TRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKG 444

Query: 825  FAANGRSPSRFSIGRGPRLQPSSSPQ----STVPSRAHPRVPSHSDSHPKLSSGIHGDEE 880
                  SPS     R   L  S   +    +   S    R     +      SG     E
Sbjct: 445  -TEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSE 503

Query: 881  DEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQG 940
            DE+P  + V N  V    R            SP R AS         +P+    +T P+G
Sbjct: 504  DERPKRSHVKNGEVGRRRRH-----------SPSRSAS--------PSPRKRQKETSPRG 544

Query: 941  KYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGR 1000
            +                      SP   P    R  SPA PP  R    P  PRR TP  
Sbjct: 545  R-------------------RRRSPSPPPTRRRRSPSPAPPPRRRRTPTPP-PRRRTPSP 584

Query: 1001 APQQQPPPPVATS-----QHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDP 1055
             P+++ P P   S     ++ P P  +    SP  P     +   P P  + R   S  P
Sbjct: 585  PPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPP---KRRASPSPPPKRRVSHSPPP 641

Query: 1056 YTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQV-E 1114
               SS      +     +  +GS    ST    ++ R+P      + + +  P+  Q   
Sbjct: 642  KQRSSPVTKRRSPSLSSKHRKGSSPSRST----REARSP--QPNKRHSPSPRPRAPQTSS 695

Query: 1115 SPTGAGAGGDHRSQRGHAASPA-RPSR---------------PGGPQSRARV-PSRAAPG 1157
            SP     G     QR  + SP+ RP R                  PQS  RV  SR+  G
Sbjct: 696  SPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSG 755

Query: 1158 KSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGK 1213
              EP +K+P +  S     +       A   K  K    S S P+  +S    GGK
Sbjct: 756  SPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPR--NSDQEGGGK 809



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 126/546 (23%), Positives = 196/546 (35%), Gaps = 82/546 (15%)

Query: 830  RSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKP--LPA 887
            RSP R    R P  +  SSP      R+H R P H     K  S     E+ EK   LP 
Sbjct: 170  RSPRRRK-SRSPSPRRRSSPVRRERKRSHSRSPRH---RTKSRSPSPAPEKKEKTPELPE 225

Query: 888  TVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLAS 947
              V    PS      +    D+ + P+       KEP PE       +       S   S
Sbjct: 226  PSVKVKEPSVQE---ATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRS 282

Query: 948  KAQDVQQSTDADTEGHS-PKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQP 1006
            K++     T + +  H+ P+ +  S  R  SP R P+ R  + PS PRR TP   P++ P
Sbjct: 283  KSRS---RTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPR--RRPS-PRRRTP---PRRMP 333

Query: 1007 PPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPT 1066
            PPP    +H    +SR   R   +   SL+ +     +S+ RS     P   SS    P 
Sbjct: 334  PPP----RHR---RSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSP---PR 383

Query: 1067 ALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHR 1126
              +     A            A       H+   +++  +      V     +G    H+
Sbjct: 384  KTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHK 443

Query: 1127 -SQRGHAASPA-RPSRPGGPQSRARVPSRAAPGKSEPPSKR-----PLSSKSQQSVSAED 1179
             +++  + SPA +P +    +S      + A   S    ++       SS    S S+ +
Sbjct: 444  GTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSE 503

Query: 1180 DEEEDAGFFKGGK---------EDLLSSSVPKWPSSSTPRGGKDADGSL--AKEEREPAI 1228
            DE       K G+             S S  K    ++PRG +    S    +  R P+ 
Sbjct: 504  DERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSP 563

Query: 1229 ALAPRGGSLA-------------------------PVKRPLPPPPGSSPRASHVPSRLPP 1263
            A  PR                              P++R   P P    R +  P   PP
Sbjct: 564  APPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPP--PP 621

Query: 1264 RSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQG 1323
            +  A+ SP     P  +  + +PP    ++P+   R   + ++ R   S  P+R S R+ 
Sbjct: 622  KRRASPSP-----PPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSS--PSR-STREA 673

Query: 1324 YNGRPN 1329
             + +PN
Sbjct: 674  RSPQPN 679



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 169/829 (20%), Positives = 260/829 (31%), Gaps = 179/829 (21%)

Query: 341  ERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYA 400
            ER    S S   RT   +P+ APE     P              LPE   KVKE      
Sbjct: 192  ERKRSHSRSPRHRTKSRSPSPAPEKKEKTP-------------ELPEPSVKVKE------ 232

Query: 401  PALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKA 460
            P+++            +TS ++   +P                          +P   + 
Sbjct: 233  PSVQ---------EATSTSDILKVPKP------------------------EPIPEPKEP 259

Query: 461  DVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAP 520
              E+N++   + EK  P S S     S      P+  + R         +++  +   +P
Sbjct: 260  SPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRR--------RHRSRSRSYSP 311

Query: 521  -RKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAP 579
             R+P  R                      R  SP      +   R + PP RH  S    
Sbjct: 312  RRRPSPR----------------------RRPSPR----RRTPPRRMPPPPRHRRS---- 341

Query: 580  GRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASP-------AHHASTQGTSHR 632
             R+ VR R  +     G      S  ++  P  PP  ++SP       +  AS     HR
Sbjct: 342  -RSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHR 400

Query: 633  PSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAK 692
            PS PA+                           P+   SP+ Q  +   + R SV PG  
Sbjct: 401  PSPPAT-------------------------PPPKTRHSPTPQQSNRTRKSRVSVSPG-- 433

Query: 693  PASPARRTPHSGAAEEDSSASAPP------SRLSPPHGGSSRLLPTQPHLSSPLSKGGKD 746
              +  + T H G  + +S + AP       S      GG      +         +  + 
Sbjct: 434  -RTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQS 492

Query: 747  GEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATA- 805
              D+ +++S+   R   S   +  +  R + S    AS        +    GR+  + + 
Sbjct: 493  SSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSP 552

Query: 806  -QTLRARPASGHFHLLRHK-------------PFAANGRSPSRFSIGRGPRLQPSSSPQS 851
              T R R  S      R +             P      SP R+S     R  PS  P+ 
Sbjct: 553  PPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKR 612

Query: 852  TVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLR- 910
               S   P     S S P      H     ++  P T       SS  +  S      R 
Sbjct: 613  RTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTRE 672

Query: 911  -RSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQP 969
             RSPQ     H   P P  P+++ +    +   SS   + Q    ST       S   +P
Sbjct: 673  ARSPQPN-KRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPST-RPIRRVSRTPEP 730

Query: 970  GSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVAT-------SQHHPGPQSR 1022
                + ASP+     R     SV     P       PP PV +       S   P  +++
Sbjct: 731  KKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAK 790

Query: 1023 DAGRSPSQPRLSLTQ-AGRPRPTSQGRSHSSSDPY-------------TASSRGMLPTAL 1068
                SPS PR S  +  G+ +   + + H     +              A++  + P A+
Sbjct: 791  SPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAI 850

Query: 1069 Q------NQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQ 1111
                    Q+E          TE EA+D          ++A  S+ K Q
Sbjct: 851  AAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQ 899



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 115/550 (20%), Positives = 176/550 (32%), Gaps = 120/550 (21%)

Query: 966  KAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAG 1025
            K +  S+      +R P  R  + PS  RR +P R  +++         H   P+ R   
Sbjct: 156  KEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKR--------SHSRSPRHRTKS 207

Query: 1026 RSPSQ-PRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDST 1084
            RSPS  P         P P+ + +  S  +  + S    +P   +   E  + S + +S 
Sbjct: 208  RSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKP-EPIPEPKEPSPEKNSK 266

Query: 1085 EVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGP 1144
            + + ++   P   +R+K  + +  +     SP+       HRS+    +   RPS    P
Sbjct: 267  KEKEKEKTRPRSRSRSKSRSRTRSR-----SPSHTRPRRRHRSRSRSYSPRRRPSPRRRP 321

Query: 1145 QSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWP 1204
              R R P R  P    PP +   S                             S V +  
Sbjct: 322  SPRRRTPPRRMP----PPPRHRRSR----------------------------SPVRRRR 349

Query: 1205 SSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPR 1264
             SS    G  +  S ++    P            P KR    PP  + R S  PS  PPR
Sbjct: 350  RSSASLSGSSSSSSSSRSRSPPK----------KPPKRT-SSPPRKTRRLS--PSASPPR 396

Query: 1265 SAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGY 1324
                 SP A         T  P    S TP  S R R      ++ +S  P R S +   
Sbjct: 397  RRHRPSPPA---------TPPPKTRHSPTPQQSNRTR------KSRVSVSPGRTSGK--V 439

Query: 1325 NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIK 1384
                  E +  P    KP    +    +        D+G  + A     Q         +
Sbjct: 440  TKHKGTEKRESPSPAPKPRKVELSESEE--------DKGGKMAAADSVQQRRQYRRQNQQ 491

Query: 1385 LGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTT 1444
               D        G+   S D  P     ++G                      EV ++  
Sbjct: 492  SSSD-------SGSSSSSEDERPKRSHVKNG----------------------EVGRRRR 522

Query: 1445 HPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPT 1504
            H P+ +  P+       T+   R      RR + +   T RR + +     R   T TP 
Sbjct: 523  HSPSRSASPSPRKRQKETSPRGR------RRRSPSPPPTRRRRSPSPAPPPRRRRTPTPP 576

Query: 1505 PTTPIPTCPP 1514
            P    P+ PP
Sbjct: 577  PRRRTPSPPP 586


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
           3 precursor [Homo sapiens]
          Length = 1903

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 84/335 (25%), Positives = 139/335 (41%), Gaps = 31/335 (9%)

Query: 135 IEIDGFPIKGPGPFN---ETVTEKEVPNKPLRVRVR-SSDDRLSVAWKAPRLSGAKSPRR 190
           +++  F   G GP +   + +T+  VP +PL  +    S+  + ++W  PR     +   
Sbjct: 490 VKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN--- 546

Query: 191 SRGFLLGY--GESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAA 248
              + L Y  GE G +           ++ ++ L   S+Y   L + + QG       A 
Sbjct: 547 ---YELVYKDGEHGEEQRIT--IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST--AE 599

Query: 249 LTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELA 308
           ++ R +  +     P DIS    SS S+LVSW  P +EKQ  ++   +Y+++Y       
Sbjct: 600 ISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGIIT--EYSIKYTAVDGED 656

Query: 309 RWDYKQIA----NRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPE 364
              ++ +       + L+E L   T Y   V        G  S SV  RT E  P+  P 
Sbjct: 657 DKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPR 716

Query: 365 NLNVWPVNGKPTVVAASW-DALPETE-GKVKEYILSYAPAL--KPFGAKSL--TYPGDTT 418
            + V  VN   T V  SW   +P  + G+++ Y + Y      +P G   L      D  
Sbjct: 717 KVEVEAVNS--TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ 774

Query: 419 SALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVA 453
             ++ GLQP   Y   + A   +G G  SK  +V+
Sbjct: 775 DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVS 809



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 99/420 (23%), Positives = 170/420 (40%), Gaps = 79/420 (18%)

Query: 57  VTWDPPK-DATSRPVEHYNIAY----GKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLL 111
           V+W PP  +  +  +  Y+I Y    G+  K  + + + ++T  +L+E +E    Y + +
Sbjct: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV 687

Query: 112 TAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETV---TEKEVPNKPLR-VRVR 167
           TA  H+ V                        GPGP + +V   T ++VP+ P R V V 
Sbjct: 688 TA--HTDV------------------------GPGPESLSVLIRTNEDVPSGPPRKVEVE 721

Query: 168 S-SDDRLSVAWKAPRLSGAKSPRRSRGFLLGY---------GE-SGRKMNYVPLTRDERT 216
           + +   + V+W++P       P +  G + GY         GE  G+ M    +  D + 
Sbjct: 722 AVNSTSVKVSWRSP------VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQD 775

Query: 217 HEIKKLASESVYVVSLQSMNSQG---RSQPVYRAALTKRKISEEDELDVPDDISVRVMSS 273
             I  L  E+ Y +++ +  ++G   RS+P        + +S    +     + +     
Sbjct: 776 MIISGLQPETSYSLTVTAYTTKGDGARSKP--------KLVSTTGAVPGKPRLVINHTQM 827

Query: 274 QSVLVSWVDPVLEKQKKVVASRQYTVRYREKG--ELARWDYKQIANRRVLIENLIPDTVY 331
            + L+ W  PV          + Y +++  K    L   ++ +  +     + +     Y
Sbjct: 828 NTALIQWHPPV----DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATD-IHKGASY 882

Query: 332 EFAVRISQGERDGKWSTSVFQRT-PESAPTTAPENLNVWPVNGKPTVVAASWD--ALPET 388
            F  R+S   + G     V + + PE  PT  P+NL+        T V  SW    L E 
Sbjct: 883 VF--RLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTS--TSVQLSWQPPVLAER 938

Query: 389 EGKVKEYILSYAPALKPF-GAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHS 447
            G + +Y L Y     P    + L  P DTT  L  GL+P   Y  K+RA   +G GP+S
Sbjct: 939 NGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT-GLKPDTTYDVKVRAHTSKGPGPYS 997



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 75/308 (24%), Positives = 120/308 (38%), Gaps = 27/308 (8%)

Query: 217 HEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSV 276
           + +  L+  S Y   + ++N+ GR  P     LT+   SE+     P D+  R++SS ++
Sbjct: 378 YSVAGLSPYSDYEFRVVAVNNIGRGPPS-EPVLTQT--SEQAPSSAPRDVQARMLSSTTI 434

Query: 277 LVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRV-LIENLIPDTVYEFAV 335
           LV W +P  E   ++   R Y      +  +  W    +A+ ++  I NL+P   Y   V
Sbjct: 435 LVQWKEPE-EPNGQIQGYRVYYTMDPTQ-HVNNWMKHNVADSQITTIGNLVPQKTYSVKV 492

Query: 336 RISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEY 395
                  DG  S+ +   T    P   P N    P +   T +  SW   P     +  Y
Sbjct: 493 LAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPES--ETSILLSW--TPPRSDTIANY 547

Query: 396 ILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMP 455
            L Y         +    PG  TS  + GL+P   Y F++ A + +GLG           
Sbjct: 548 ELVYKDGEHGEEQRITIEPG--TSYRLQGLKPNSLYYFRLAARSPQGLG----------- 594

Query: 456 TTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILA 515
             S A++   T  + KP  P P   S  +P+S+        P       ++ +   K  A
Sbjct: 595 -ASTAEISARTMQS-KPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651

Query: 516 NGGAPRKP 523
             G   KP
Sbjct: 652 VDGEDDKP 659



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 77/317 (24%), Positives = 126/317 (39%), Gaps = 37/317 (11%)

Query: 135  IEIDGFPIKGPGPFNE---TVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRS 191
            + +  +  KG G  ++     T   VP KP  V   +  +   + W  P          +
Sbjct: 789  LTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV--------DT 840

Query: 192  RGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESV-----YVVSLQSMNSQGRSQPVYR 246
             G L GY     + +  PLT  E + +     +  +     YV  L + N  G  + + +
Sbjct: 841  FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 900

Query: 247  AALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGE 306
                   I EE     P ++     +S SV +SW  PVL ++  ++   +YT+ YR+   
Sbjct: 901  EI----SIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIIT--KYTLLYRDI-N 953

Query: 307  LARWDYKQI---ANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAP 363
            +     +Q+   A+  + +  L PDT Y+  VR    +  G +S SV  RT       A 
Sbjct: 954  IPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFA- 1012

Query: 364  ENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVD 423
            +N +V  V    T V  SW+ +PE       + + Y       G       G  T  L+ 
Sbjct: 1013 KNFHVKAV--MKTSVLLSWE-IPENYNSAMPFKILYDD-----GKMVEEVDGRATQKLIV 1064

Query: 424  GLQPGERYLFKIRATNR 440
             L+P + Y F +  TNR
Sbjct: 1065 NLKPEKSYSFVL--TNR 1079



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 83/435 (19%), Positives = 158/435 (36%), Gaps = 57/435 (13%)

Query: 51  TKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVL 110
           ++  + ++W PP+  T   + +Y + Y       +         S+ ++ ++P  +Y+  
Sbjct: 528 SETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFR 584

Query: 111 LTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSD 170
           L A +  G+           G    EI    ++         ++   P + +     SS 
Sbjct: 585 LAARSPQGL-----------GASTAEISARTMQ---------SKPSAPPQDISCTSPSST 624

Query: 171 DRLSVAWKAPRLSGAKSPRRSRGFLLGY--------GESGRKMNYVPLTRDERTHEIKKL 222
             L V+W+ P +       +  G +  Y        GE  +    + +  D   + +++L
Sbjct: 625 SIL-VSWQPPPVE------KQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQL 677

Query: 223 ASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVD 282
              + Y +++ +    G   P   +     + +E+     P  + V  ++S SV VSW  
Sbjct: 678 EKWTEYRITVTAHTDVG---PGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRS 734

Query: 283 PVLEKQKKVVASRQYTVRY------REKGELARWDYKQIANRRVLIENLIPDTVYEFAVR 336
           PV  KQ   +  R Y V Y        KG+    D      + ++I  L P+T Y   V 
Sbjct: 735 PVPNKQHGQI--RGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVT 792

Query: 337 ISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYI 396
               + DG  S      T  + P      +N   +N         W    +T G ++ Y 
Sbjct: 793 AYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMN----TALIQWHPPVDTFGPLQGYR 848

Query: 397 LSYAPA-LKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMP 455
           L +    ++P      +   D  +A    +  G  Y+F++ A N+ G G       +++P
Sbjct: 849 LKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGASYVFRLSARNKVGFG-EEMVKEISIP 905

Query: 456 TTSKADVEQNTEDNG 470
                   QN    G
Sbjct: 906 EEVPTGFPQNLHSEG 920



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 41/166 (24%), Positives = 65/166 (39%), Gaps = 13/166 (7%)

Query: 312 YKQI---ANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNV 368
           YK+I   A  R  +  L P + YEF V        G  S  V  +T E AP++AP ++  
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 426

Query: 369 WPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTY-PGDTTSALVDGLQP 427
             ++   T +   W    E  G+++ Y + Y           + +   D+    +  L P
Sbjct: 427 RMLSS--TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVP 484

Query: 428 GERYLFKIRATNRRGLGPHS-------KAFIVAMPTTSKADVEQNT 466
            + Y  K+ A    G GP S       +  +   P   KA+ E  T
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET 530



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 18/37 (48%), Positives = 22/37 (59%)

Query: 1713 THLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVT 1749
            T + +  LKP+T Y  KV+A    G GP SPSV F T
Sbjct: 968  TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 15/42 (35%), Positives = 24/42 (57%)

Query: 1713 THLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNP 1754
            T   ++ LKPN+ YYF++ A++P G G  +  +S  T    P
Sbjct: 568  TSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKP 609


>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sapiens]
          Length = 2365

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 207/991 (20%), Positives = 345/991 (34%), Gaps = 169/991 (17%)

Query: 456  TTSKADVEQNTEDNGKPEKPE--------PSSP--SPRAPASSQHPSV-PASPQGRNAKD 504
            T++ + V+ +T +  + E P         P  P   PRA +S + PS+   SP G +A  
Sbjct: 146  TSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAG 205

Query: 505  LLLDLKNKILANGG---APRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQD 561
                 K +    GG        +LR +    L+   + +T        + S M+P     
Sbjct: 206  Q----KKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLT--------QASSMTPHSGPR 253

Query: 562  QKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPA 621
               +   P++   +  A  R   RA  P    +    +     +TQ       S     +
Sbjct: 254  STTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRAS---STQQEISRASSTQQETS 310

Query: 622  HHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQS----P 677
              +STQ  + R S            + ED     S      +  PR A SPSR +    P
Sbjct: 311  RASSTQEDTPRAS-----------STQEDTPRASSTQ----WNTPR-ASSPSRSTQLDNP 354

Query: 678  SSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLS 737
             +    + +        +P R  P +   ++D   ++ P+R +      +         +
Sbjct: 355  RTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKA 414

Query: 738  SPLSKGGKDGEDAPATN--------SNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESH 789
            S  S   +   D P T+        +++PSR+T  +  +S  + R        +S   + 
Sbjct: 415  SRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTS-CAQRDNPRASRTSSPNRAT 473

Query: 790  GDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGR-GPRLQPSSS 848
             D  R        + AQ    R +S         P  A   +P+     R  PR   +SS
Sbjct: 474  RDNPRT-------SCAQRDNPRASS---------PSRATRDNPTTSCAQRDNPRASRTSS 517

Query: 849  PQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWED 908
            P     +R +PR       +P+ SS      ++  P  +    D+  +S     +R   D
Sbjct: 518  PNRA--TRDNPRTSCAQRDNPRASSPNRAARDN--PTTSCAQRDNPRASRTSSPNRATRD 573

Query: 909  ------LRRSPQRGASLHRKEPIPENPKSTGADT-HPQGKYSSLASKAQDVQQSTDADTE 961
                   +R   R +S +R     +NP ++ A   +P+   +S  ++A      T     
Sbjct: 574  NPRTSCAQRDNPRASSPNRATR--DNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQR 631

Query: 962  GHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQS 1021
             +   + P  T +  SP    A R       PR  +P R  QQ+ P      + +P   S
Sbjct: 632  DNPRASSPNRTTQQDSPRTSCARRDD-----PRASSPNRTIQQENPRTSCALRDNPRASS 686

Query: 1022 RDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTA------LQNQDEDA 1075
                     PR S  Q   PR +S  R+    +P T+ +R   P A      +Q  +   
Sbjct: 687  PSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRT 746

Query: 1076 QGSYDDD----STEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGH 1131
              +  D+    S     Q         R      S P     ++P  + A  D+      
Sbjct: 747  SCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNL----R 802

Query: 1132 AASPARPSRPGGPQS--RARVPSRAAPGKSEPPSK-------RPLSSKSQQSVS---AED 1179
            A+SP R ++   P++  +  +P  ++  +  P +        RP  ++  ++ S     D
Sbjct: 803  ASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRD 862

Query: 1180 DEEEDAGFFKGGKEDLLSSS---VPKW--PSSSTP-RGGKD------------ADG---- 1217
            +    +      KE+L  SS     +W  P +S+P R  KD            +DG    
Sbjct: 863  NPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTS 922

Query: 1218 --SLAKEEREP--AIALAPRGGSLAPVKRPLPP----PPGSS--PRASHVPSRL------ 1261
              S +K+   P  +IAL P  G       P  P    PP SS  P   ++PSR       
Sbjct: 923  SPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHN 982

Query: 1262 -----PPRSAATVSPVAGTHPWPQYTTRAPP-----GHFSTTPMLSLRQRMMHARFRNPL 1311
                   R+++ V P A   P        PP     GH       S  + + H  F  P 
Sbjct: 983  PGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPF--PF 1040

Query: 1312 SRQPARPSYRQGYNGRPNVEGKVLPGSNGKP 1342
              +P  P     ++  P +   V  G    P
Sbjct: 1041 FPEPRAPESEPPHHEPPYIPPAVCIGHRDAP 1071



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 185/840 (22%), Positives = 274/840 (32%), Gaps = 126/840 (15%)

Query: 549  REDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQP 608
            + D+P +    +D  R   P        +    T       + P R   D P  S A + 
Sbjct: 740  QRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRD 799

Query: 609  RPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRP 668
               A     A+   +  T    + P   ++  DN      + +    +L P         
Sbjct: 800  NLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRD----NLRPTCTQRDRTQ 855

Query: 669  ALSPSRQSPSSVLRDRSSVHPGAKPASPARRT---------PHSG------------AAE 707
            + S  R +P +      +     +P+SP R T         PH                +
Sbjct: 856  SFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQ 915

Query: 708  EDSSASAPPSRL--SPPHGGSSRLLPTQ---PHLSSPLSKGGKDGEDAP--ATNSNAPSR 760
             D   ++ PSR   S     S  L PTQ   P  SSP      D   +    T  N PSR
Sbjct: 916  SDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSR 975

Query: 761  STMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLL 820
            +T SS    H S+    S    A+ G        E              A  AS     L
Sbjct: 976  ATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSP--EPSQPPCAVCIGHRDAPRASSPPRYL 1033

Query: 821  RHKPFA--ANGRSPSRFSIGRGPRLQPSS-------SPQSTVPSR-----AHPRVPSHSD 866
            +H PF      R+P        P   P +       +P+++ P R       P +P  SD
Sbjct: 1034 QHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSD 1093

Query: 867  SHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPI-----SRGWEDLRRSPQRGA---- 917
            +  +  S  H  E  + P P  +     P +S  P      S  ++DL R+         
Sbjct: 1094 AEHQCQSPQH--EPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSM 1151

Query: 918  -SLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDR-H 975
             SLH    IP  P   G    P   +SS   +A +       D  G S ++   STD  H
Sbjct: 1152 DSLHECPHIP-TPVCIGHRDAPS--FSSPPRQAPEPSLFFQ-DPPGTSMESLAPSTDSLH 1207

Query: 976  ASPARPPAARSQQHPSVPRRMTPGR---------APQQQP-------------------- 1006
             SP   P      H   PR  +P R         AP   P                    
Sbjct: 1208 GSPVLIPQV-CIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLE 1266

Query: 1007 ----------PPPVATSQHHPGPQSR--DAGRSPSQPRLSLTQA-GRPRPTSQGRSHSSS 1053
                      PPP   +Q  PGPQ++    GR+ S  R  + +  G+ R     R   ++
Sbjct: 1267 REEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQER-----RKSEAA 1321

Query: 1054 DPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKH--Q 1111
              + A   G      Q Q   +Q      S     Q    PA  A     + + P H   
Sbjct: 1322 GAFQAQDEGRSQQPSQGQ---SQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWS 1378

Query: 1112 QVESPTG-AGAGGDHRSQRGHAASPARPSRPGGP----QSRARVPSRAAPGKSEPPSKRP 1166
              + P G     G     R  A +P R  R   P    Q+  R P      + EPP  + 
Sbjct: 1379 PEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQG 1438

Query: 1167 LSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREP 1226
                 ++S S+++      G++  G+  L ++  P+     T R  K++ G     E +P
Sbjct: 1439 PHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKP 1498

Query: 1227 AIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAP 1286
               L    G  +P+  P     G +  +    S  P    A      G  P+P+ + R P
Sbjct: 1499 THELPRELGKRSPLTSPPENWGGPAESSQSWHSGTP---TAVGWGAEGACPYPRGSERRP 1555



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 20/72 (27%), Positives = 31/72 (43%), Gaps = 2/72 (2%)

Query: 1443 TTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTT 1502
            +T   T+    T   TP  ++T      A++ +  T R ++  R T       RT++T  
Sbjct: 304  STQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQL--DNPRTSSTQQ 361

Query: 1503 PTPTTPIPTCPP 1514
              P T  PTC P
Sbjct: 362  DNPQTSFPTCTP 373


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
           precursor [Homo sapiens]
          Length = 1912

 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 85/344 (24%), Positives = 141/344 (40%), Gaps = 40/344 (11%)

Query: 135 IEIDGFPIKGPGPFN---ETVTEKEVPNKPLRVRVR-SSDDRLSVAWKAPRLSGAKSPRR 190
           +++  F   G GP +   + +T+  VP +PL  +    S+  + ++W  PR     +   
Sbjct: 490 VKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN--- 546

Query: 191 SRGFLLGY--GESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAA 248
              + L Y  GE G +           ++ ++ L   S+Y   L + + QG       A 
Sbjct: 547 ---YELVYKDGEHGEEQRIT--IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST--AE 599

Query: 249 LTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELA 308
           ++ R +  +     P DIS    SS S+LVSW  P +EKQ  ++   +Y+++Y       
Sbjct: 600 ISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGIIT--EYSIKYTAVDGED 656

Query: 309 RWDYKQIA----NRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPE 364
              ++ +       + L+E L   T Y   V        G  S SV  RT E  P+  P 
Sbjct: 657 DKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPR 716

Query: 365 NLNVWPVNGKPTVVAASW-DALPETE-GKVKEYILSYA----------PALKPFGAKSLT 412
            + V  VN   T V  SW   +P  + G+++ Y + Y           P LK        
Sbjct: 717 KVEVEAVNS--TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ 774

Query: 413 YPGDTTS---ALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVA 453
           +  D T+    ++ GLQP   Y   + A   +G G  SK  +V+
Sbjct: 775 WEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVS 818



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 75/308 (24%), Positives = 120/308 (38%), Gaps = 27/308 (8%)

Query: 217 HEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSV 276
           + +  L+  S Y   + ++N+ GR  P     LT+   SE+     P D+  R++SS ++
Sbjct: 378 YSVAGLSPYSDYEFRVVAVNNIGRGPPS-EPVLTQT--SEQAPSSAPRDVQARMLSSTTI 434

Query: 277 LVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRV-LIENLIPDTVYEFAV 335
           LV W +P  E   ++   R Y      +  +  W    +A+ ++  I NL+P   Y   V
Sbjct: 435 LVQWKEPE-EPNGQIQGYRVYYTMDPTQ-HVNNWMKHNVADSQITTIGNLVPQKTYSVKV 492

Query: 336 RISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEY 395
                  DG  S+ +   T    P   P N    P +   T +  SW   P     +  Y
Sbjct: 493 LAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPES--ETSILLSW--TPPRSDTIANY 547

Query: 396 ILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMP 455
            L Y         +    PG  TS  + GL+P   Y F++ A + +GLG           
Sbjct: 548 ELVYKDGEHGEEQRITIEPG--TSYRLQGLKPNSLYYFRLAARSPQGLG----------- 594

Query: 456 TTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILA 515
             S A++   T  + KP  P P   S  +P+S+        P       ++ +   K  A
Sbjct: 595 -ASTAEISARTMQS-KPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651

Query: 516 NGGAPRKP 523
             G   KP
Sbjct: 652 VDGEDDKP 659



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 99/430 (23%), Positives = 170/430 (39%), Gaps = 90/430 (20%)

Query: 57   VTWDPPK-DATSRPVEHYNIAY----GKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLL 111
            V+W PP  +  +  +  Y+I Y    G+  K  + + + ++T  +L+E +E    Y + +
Sbjct: 628  VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV 687

Query: 112  TAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETV---TEKEVPNKPLR-VRVR 167
            TA  H+ V                        GPGP + +V   T ++VP+ P R V V 
Sbjct: 688  TA--HTDV------------------------GPGPESLSVLIRTNEDVPSGPPRKVEVE 721

Query: 168  S-SDDRLSVAWKAPRLSGAKSPRRSRGFLLGYG------ESGRKMNYVPLTRD------- 213
            + +   + V+W++P       P +  G + GY       E+G      P+ +D       
Sbjct: 722  AVNSTSVKVSWRSP------VPNKQHGQIRGYQVHYVRMENGEPKGQ-PMLKDVMLADAQ 774

Query: 214  -------ERTHEIKKLASESVYVVSLQSMNSQG---RSQPVYRAALTKRKISEEDELDVP 263
                   E    I  L  E+ Y +++ +  ++G   RS+P        + +S    +   
Sbjct: 775  WEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKP--------KLVSTTGAVPGK 826

Query: 264  DDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKG--ELARWDYKQIANRRVL 321
              + +      + L+ W  PV          + Y +++  K    L   ++ +  +    
Sbjct: 827  PRLVINHTQMNTALIQWHPPV----DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTA 882

Query: 322  IENLIPDTVYEFAVRISQGERDGKWSTSVFQRT-PESAPTTAPENLNVWPVNGKPTVVAA 380
             + +     Y F  R+S   + G     V + + PE  PT  P+NL+        T V  
Sbjct: 883  TD-IHKGASYVF--RLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTS--TSVQL 937

Query: 381  SWD--ALPETEGKVKEYILSYAPALKPF-GAKSLTYPGDTTSALVDGLQPGERYLFKIRA 437
            SW    L E  G + +Y L Y     P    + L  P DTT  L  GL+P   Y  K+RA
Sbjct: 938  SWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT-GLKPDTTYDVKVRA 996

Query: 438  TNRRGLGPHS 447
               +G GP+S
Sbjct: 997  HTSKGPGPYS 1006



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 85/444 (19%), Positives = 161/444 (36%), Gaps = 66/444 (14%)

Query: 51  TKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVL 110
           ++  + ++W PP+  T   + +Y + Y       +         S+ ++ ++P  +Y+  
Sbjct: 528 SETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFR 584

Query: 111 LTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSD 170
           L A +  G+           G    EI    ++         ++   P + +     SS 
Sbjct: 585 LAARSPQGL-----------GASTAEISARTMQ---------SKPSAPPQDISCTSPSST 624

Query: 171 DRLSVAWKAPRLSGAKSPRRSRGFLLGY--------GESGRKMNYVPLTRDERTHEIKKL 222
             L V+W+ P +       +  G +  Y        GE  +    + +  D   + +++L
Sbjct: 625 SIL-VSWQPPPVE------KQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQL 677

Query: 223 ASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVD 282
              + Y +++ +    G   P   +     + +E+     P  + V  ++S SV VSW  
Sbjct: 678 EKWTEYRITVTAHTDVG---PGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRS 734

Query: 283 PVLEKQKKVVASRQYTVRY--REKGEL-------------ARWDYKQIANRRVLIENLIP 327
           PV  KQ   +  R Y V Y   E GE              A+W++       ++I  L P
Sbjct: 735 PVPNKQHGQI--RGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQP 792

Query: 328 DTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPE 387
           +T Y   V     + DG  S      T  + P      +N   +N         W    +
Sbjct: 793 ETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMN----TALIQWHPPVD 848

Query: 388 TEGKVKEYILSYA-PALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPH 446
           T G ++ Y L +    ++P      +   D  +A    +  G  Y+F++ A N+ G G  
Sbjct: 849 TFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTA--TDIHKGASYVFRLSARNKVGFG-E 905

Query: 447 SKAFIVAMPTTSKADVEQNTEDNG 470
                +++P        QN    G
Sbjct: 906 EMVKEISIPEEVPTGFPQNLHSEG 929



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 77/317 (24%), Positives = 126/317 (39%), Gaps = 37/317 (11%)

Query: 135  IEIDGFPIKGPGPFNE---TVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRS 191
            + +  +  KG G  ++     T   VP KP  V   +  +   + W  P          +
Sbjct: 798  LTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV--------DT 849

Query: 192  RGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESV-----YVVSLQSMNSQGRSQPVYR 246
             G L GY     + +  PLT  E + +     +  +     YV  L + N  G  + + +
Sbjct: 850  FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 909

Query: 247  AALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGE 306
                   I EE     P ++     +S SV +SW  PVL ++  ++   +YT+ YR+   
Sbjct: 910  EI----SIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIIT--KYTLLYRDI-N 962

Query: 307  LARWDYKQI---ANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAP 363
            +     +Q+   A+  + +  L PDT Y+  VR    +  G +S SV  RT       A 
Sbjct: 963  IPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFA- 1021

Query: 364  ENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVD 423
            +N +V  V    T V  SW+ +PE       + + Y       G       G  T  L+ 
Sbjct: 1022 KNFHVKAV--MKTSVLLSWE-IPENYNSAMPFKILYDD-----GKMVEEVDGRATQKLIV 1073

Query: 424  GLQPGERYLFKIRATNR 440
             L+P + Y F +  TNR
Sbjct: 1074 NLKPEKSYSFVL--TNR 1088



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 41/166 (24%), Positives = 65/166 (39%), Gaps = 13/166 (7%)

Query: 312 YKQI---ANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNV 368
           YK+I   A  R  +  L P + YEF V        G  S  V  +T E AP++AP ++  
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 426

Query: 369 WPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTY-PGDTTSALVDGLQP 427
             ++   T +   W    E  G+++ Y + Y           + +   D+    +  L P
Sbjct: 427 RMLSS--TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVP 484

Query: 428 GERYLFKIRATNRRGLGPHS-------KAFIVAMPTTSKADVEQNT 466
            + Y  K+ A    G GP S       +  +   P   KA+ E  T
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET 530



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 18/37 (48%), Positives = 22/37 (59%)

Query: 1713 THLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVT 1749
            T + +  LKP+T Y  KV+A    G GP SPSV F T
Sbjct: 977  TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 15/42 (35%), Positives = 24/42 (57%)

Query: 1713 THLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNP 1754
            T   ++ LKPN+ YYF++ A++P G G  +  +S  T    P
Sbjct: 568  TSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKP 609


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
           2 precursor [Homo sapiens]
          Length = 1899

 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 85/344 (24%), Positives = 141/344 (40%), Gaps = 40/344 (11%)

Query: 135 IEIDGFPIKGPGPFN---ETVTEKEVPNKPLRVRVR-SSDDRLSVAWKAPRLSGAKSPRR 190
           +++  F   G GP +   + +T+  VP +PL  +    S+  + ++W  PR     +   
Sbjct: 477 VKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN--- 533

Query: 191 SRGFLLGY--GESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAA 248
              + L Y  GE G +           ++ ++ L   S+Y   L + + QG       A 
Sbjct: 534 ---YELVYKDGEHGEEQRIT--IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST--AE 586

Query: 249 LTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELA 308
           ++ R +  +     P DIS    SS S+LVSW  P +EKQ  ++   +Y+++Y       
Sbjct: 587 ISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGIIT--EYSIKYTAVDGED 643

Query: 309 RWDYKQIA----NRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPE 364
              ++ +       + L+E L   T Y   V        G  S SV  RT E  P+  P 
Sbjct: 644 DKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPR 703

Query: 365 NLNVWPVNGKPTVVAASW-DALPETE-GKVKEYILSYA----------PALKPFGAKSLT 412
            + V  VN   T V  SW   +P  + G+++ Y + Y           P LK        
Sbjct: 704 KVEVEAVNS--TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ 761

Query: 413 YPGDTTS---ALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVA 453
           +  D T+    ++ GLQP   Y   + A   +G G  SK  +V+
Sbjct: 762 WEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVS 805



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 75/308 (24%), Positives = 120/308 (38%), Gaps = 27/308 (8%)

Query: 217 HEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSV 276
           + +  L+  S Y   + ++N+ GR  P     LT+   SE+     P D+  R++SS ++
Sbjct: 365 YSVAGLSPYSDYEFRVVAVNNIGRGPPS-EPVLTQT--SEQAPSSAPRDVQARMLSSTTI 421

Query: 277 LVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRV-LIENLIPDTVYEFAV 335
           LV W +P  E   ++   R Y      +  +  W    +A+ ++  I NL+P   Y   V
Sbjct: 422 LVQWKEPE-EPNGQIQGYRVYYTMDPTQ-HVNNWMKHNVADSQITTIGNLVPQKTYSVKV 479

Query: 336 RISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEY 395
                  DG  S+ +   T    P   P N    P +   T +  SW   P     +  Y
Sbjct: 480 LAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPES--ETSILLSW--TPPRSDTIANY 534

Query: 396 ILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMP 455
            L Y         +    PG  TS  + GL+P   Y F++ A + +GLG           
Sbjct: 535 ELVYKDGEHGEEQRITIEPG--TSYRLQGLKPNSLYYFRLAARSPQGLG----------- 581

Query: 456 TTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILA 515
             S A++   T  + KP  P P   S  +P+S+        P       ++ +   K  A
Sbjct: 582 -ASTAEISARTMQS-KPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638

Query: 516 NGGAPRKP 523
             G   KP
Sbjct: 639 VDGEDDKP 646



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 99/430 (23%), Positives = 170/430 (39%), Gaps = 90/430 (20%)

Query: 57  VTWDPPK-DATSRPVEHYNIAY----GKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLL 111
           V+W PP  +  +  +  Y+I Y    G+  K  + + + ++T  +L+E +E    Y + +
Sbjct: 615 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV 674

Query: 112 TAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETV---TEKEVPNKPLR-VRVR 167
           TA  H+ V                        GPGP + +V   T ++VP+ P R V V 
Sbjct: 675 TA--HTDV------------------------GPGPESLSVLIRTNEDVPSGPPRKVEVE 708

Query: 168 S-SDDRLSVAWKAPRLSGAKSPRRSRGFLLGYG------ESGRKMNYVPLTRD------- 213
           + +   + V+W++P       P +  G + GY       E+G      P+ +D       
Sbjct: 709 AVNSTSVKVSWRSP------VPNKQHGQIRGYQVHYVRMENGEPKGQ-PMLKDVMLADAQ 761

Query: 214 -------ERTHEIKKLASESVYVVSLQSMNSQG---RSQPVYRAALTKRKISEEDELDVP 263
                  E    I  L  E+ Y +++ +  ++G   RS+P        + +S    +   
Sbjct: 762 WEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKP--------KLVSTTGAVPGK 813

Query: 264 DDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKG--ELARWDYKQIANRRVL 321
             + +      + L+ W  PV          + Y +++  K    L   ++ +  +    
Sbjct: 814 PRLVINHTQMNTALIQWHPPV----DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTA 869

Query: 322 IENLIPDTVYEFAVRISQGERDGKWSTSVFQRT-PESAPTTAPENLNVWPVNGKPTVVAA 380
            + +     Y F  R+S   + G     V + + PE  PT  P+NL+        T V  
Sbjct: 870 TD-IHKGASYVF--RLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTS--TSVQL 924

Query: 381 SWD--ALPETEGKVKEYILSYAPALKPF-GAKSLTYPGDTTSALVDGLQPGERYLFKIRA 437
           SW    L E  G + +Y L Y     P    + L  P DTT  L  GL+P   Y  K+RA
Sbjct: 925 SWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLT-GLKPDTTYDVKVRA 983

Query: 438 TNRRGLGPHS 447
              +G GP+S
Sbjct: 984 HTSKGPGPYS 993



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 85/444 (19%), Positives = 161/444 (36%), Gaps = 66/444 (14%)

Query: 51  TKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVL 110
           ++  + ++W PP+  T   + +Y + Y       +         S+ ++ ++P  +Y+  
Sbjct: 515 SETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFR 571

Query: 111 LTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSD 170
           L A +  G+           G    EI    ++         ++   P + +     SS 
Sbjct: 572 LAARSPQGL-----------GASTAEISARTMQ---------SKPSAPPQDISCTSPSST 611

Query: 171 DRLSVAWKAPRLSGAKSPRRSRGFLLGY--------GESGRKMNYVPLTRDERTHEIKKL 222
             L V+W+ P +       +  G +  Y        GE  +    + +  D   + +++L
Sbjct: 612 SIL-VSWQPPPVE------KQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQL 664

Query: 223 ASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVD 282
              + Y +++ +    G   P   +     + +E+     P  + V  ++S SV VSW  
Sbjct: 665 EKWTEYRITVTAHTDVG---PGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRS 721

Query: 283 PVLEKQKKVVASRQYTVRY--REKGEL-------------ARWDYKQIANRRVLIENLIP 327
           PV  KQ   +  R Y V Y   E GE              A+W++       ++I  L P
Sbjct: 722 PVPNKQHGQI--RGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQP 779

Query: 328 DTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPE 387
           +T Y   V     + DG  S      T  + P      +N   +N         W    +
Sbjct: 780 ETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMN----TALIQWHPPVD 835

Query: 388 TEGKVKEYILSYA-PALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPH 446
           T G ++ Y L +    ++P      +   D  +A    +  G  Y+F++ A N+ G G  
Sbjct: 836 TFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTA--TDIHKGASYVFRLSARNKVGFG-E 892

Query: 447 SKAFIVAMPTTSKADVEQNTEDNG 470
                +++P        QN    G
Sbjct: 893 EMVKEISIPEEVPTGFPQNLHSEG 916



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 77/317 (24%), Positives = 126/317 (39%), Gaps = 37/317 (11%)

Query: 135  IEIDGFPIKGPGPFNE---TVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRS 191
            + +  +  KG G  ++     T   VP KP  V   +  +   + W  P          +
Sbjct: 785  LTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV--------DT 836

Query: 192  RGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESV-----YVVSLQSMNSQGRSQPVYR 246
             G L GY     + +  PLT  E + +     +  +     YV  L + N  G  + + +
Sbjct: 837  FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 896

Query: 247  AALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGE 306
                   I EE     P ++     +S SV +SW  PVL ++  ++   +YT+ YR+   
Sbjct: 897  EI----SIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIIT--KYTLLYRDI-N 949

Query: 307  LARWDYKQI---ANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAP 363
            +     +Q+   A+  + +  L PDT Y+  VR    +  G +S SV  RT       A 
Sbjct: 950  IPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFA- 1008

Query: 364  ENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVD 423
            +N +V  V    T V  SW+ +PE       + + Y       G       G  T  L+ 
Sbjct: 1009 KNFHVKAV--MKTSVLLSWE-IPENYNSAMPFKILYDD-----GKMVEEVDGRATQKLIV 1060

Query: 424  GLQPGERYLFKIRATNR 440
             L+P + Y F +  TNR
Sbjct: 1061 NLKPEKSYSFVL--TNR 1075



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 41/166 (24%), Positives = 65/166 (39%), Gaps = 13/166 (7%)

Query: 312 YKQI---ANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNV 368
           YK+I   A  R  +  L P + YEF V        G  S  V  +T E AP++AP ++  
Sbjct: 354 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 413

Query: 369 WPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTY-PGDTTSALVDGLQP 427
             ++   T +   W    E  G+++ Y + Y           + +   D+    +  L P
Sbjct: 414 RMLSS--TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVP 471

Query: 428 GERYLFKIRATNRRGLGPHS-------KAFIVAMPTTSKADVEQNT 466
            + Y  K+ A    G GP S       +  +   P   KA+ E  T
Sbjct: 472 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET 517



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 18/37 (48%), Positives = 22/37 (59%)

Query: 1713 THLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVT 1749
            T + +  LKP+T Y  KV+A    G GP SPSV F T
Sbjct: 964  TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 15/42 (35%), Positives = 24/42 (57%)

Query: 1713 THLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNP 1754
            T   ++ LKPN+ YYF++ A++P G G  +  +S  T    P
Sbjct: 555  TSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKP 596


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 179/716 (25%), Positives = 241/716 (33%), Gaps = 116/716 (16%)

Query: 586  ARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLV 645
            A +P    R G  +     A+     APP+ + SP    S+ G +   + P  L    L 
Sbjct: 68   ATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGP-VSSPGRASGTTRPGPLGQKGLR 126

Query: 646  DSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGA 705
             S E+  A G    K   A  R ALS   +      RD S   PG    + ARR+  +G 
Sbjct: 127  ISAEETVARG----KATEAPKRSALSAGAR------RDTSGPTPGTPSPAMARRSRAAGT 176

Query: 706  AEEDSSASAPPSRLSPPHGG-------SSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAP 758
             E      AP +R  PP  G       +S    T+P  ++        G   PA+ S + 
Sbjct: 177  -EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS 235

Query: 759  SRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFH 818
            S + +SS   S  S+R      A  S  +  G        R  + T     A PA G   
Sbjct: 236  SATPLSSPARSGPSARGTPRAPAHPSQPKPKG----LQALRPPQVTPPRKDAAPALGP-- 289

Query: 819  LLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGD 878
             L   P A    S    S    P LQ   SP +T PS+A   + S     P L +     
Sbjct: 290  -LSSSPLATPSPSAPP-SPSAPPSLQTLPSPPATPPSQATTSLGS-----PTLQA----- 337

Query: 879  EEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKE---PIPENPKSTGAD 935
                  LP+  ++       + P +     L+  P   AS        P P+ P +    
Sbjct: 338  --THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395

Query: 936  THPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRR 995
               Q  +S   S       S  A     SP   P +T    +P    A   Q  PS P  
Sbjct: 396  LL-QAPFSPPPSPPVQAPFSPPA-----SPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 449

Query: 996  --MTPGRAPQQQPPPPVATSQHH---PGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSH 1050
              M+P   P  Q PPP+A        P PQ+  A  +P    L       P P +     
Sbjct: 450  PPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQAL-------PSPPASFPGQ 502

Query: 1051 SSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKH 1110
            +   P  ++S  M P A                          P  AA   +   S P  
Sbjct: 503  APFSP--SASLPMSPLATPPPQAP-------------------PVLAAPLLQVPPSPPA- 540

Query: 1111 QQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRA--RVPSRAAPGKSEPPSKRPLS 1168
                SPT                +P RP  PG   S +  R+    APG   PPS+ P S
Sbjct: 541  ----SPT--------------LQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 582

Query: 1169 SKSQ-----QSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEE 1223
            + S       S SA    EE  G+  G +            ++S P   + A    A   
Sbjct: 583  TLSGPDLAGHSSSATSTPEELRGYDSGPEGGA---------AASPPPDAELAACHPAAWS 633

Query: 1224 REPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWP 1279
            R PA  LA RG   AP+  P    PGS+     +     P SA          P P
Sbjct: 634  RGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP 689



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 153/644 (23%), Positives = 210/644 (32%), Gaps = 86/644 (13%)

Query: 472  PEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILAN-----GGAPRKPQLR 526
            P    P   +PR P S + P  P +P           +  K LA      GGA       
Sbjct: 17   PAARAPGLLTPRPPGSPRPPP-PVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAP 75

Query: 527  AKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRP-PSRHGHSVVAPGRTAVR 585
                           GE    ++  SP   S       T RP P       ++   T  R
Sbjct: 76   RAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 135

Query: 586  ARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLV 645
             +    P+R  +        + P PG P  A A  +  A T+    RP+           
Sbjct: 136  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA----------- 184

Query: 646  DSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGA 705
                              A+PRP     R+S SS     +S H   +P+  ARR P +G 
Sbjct: 185  ----------------PSARPRPPTEGPRKSVSS-----ASEHSTTEPSPAARRRPSAGG 223

Query: 706  -----AEEDSSASAPPSRLSPPHGGSSRLLPTQP-HLSSPLSKGG---KDGEDAPATNSN 756
                 A    S+SA P       G S+R  P  P H S P  KG    +  +  P     
Sbjct: 224  GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA 283

Query: 757  APSRSTMSSSVSSHLSSRTQVSEGAEAS-------DGESHGDGDREDGGRQAEATAQTLR 809
            AP+   +SSS  +  S     S  A  S                   G    +AT   L 
Sbjct: 284  APALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 343

Query: 810  ARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHP 869
            + P S    L    P A    +         P   P  SP +T PS   P+ P+      
Sbjct: 344  SPPLSP---LATPPPQAPPALALPPLQAPPSPPASPPLSPLAT-PS---PQAPN------ 390

Query: 870  KLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRK---EPIP 926
              +  +H  +    P P+  V       +  P+S       ++P   A+   +    P  
Sbjct: 391  --ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 448

Query: 927  ENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARS 986
              P S  A   PQ      A   Q  +    A     +P  Q   +   + P + P + S
Sbjct: 449  SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508

Query: 987  QQHPSVPRRMTPGRAPQ-------QQPPPPVA--TSQHHPGPQSRDAGRSPSQPRLSLTQ 1037
               P  P    P +AP        Q PP P A  T Q    P +     S S PRL+L  
Sbjct: 509  ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 568

Query: 1038 A-GRPRPTSQGRSHSSSDPYTA---SSRGMLPTALQNQDEDAQG 1077
            A G P P S+  S + S P  A   SS    P  L+  D   +G
Sbjct: 569  APGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 612



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 91/371 (24%), Positives = 130/371 (35%), Gaps = 64/371 (17%)

Query: 979  ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSP---------- 1028
            AR PAAR+      P  +TP      +PPPPV  +       +   GR P          
Sbjct: 14   ARTPAARA------PGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG 67

Query: 1029 -----SQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDS 1083
                 S PR   T+  RP  + +G     + P   +S G + +  +       G      
Sbjct: 68   ATIPESAPRAGPTRTSRPPASGRGER---APPAKNTSPGPVSSPGRASGTTRPGPLGQKG 124

Query: 1084 TEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGG 1143
              + A++  A   A  A + +A             AGA  D         SPA   R   
Sbjct: 125  LRISAEETVARGKATEAPKRSA-----------LSAGARRDTSGPTPGTPSPAMARRSRA 173

Query: 1144 PQSRARVPSRAAPGKSEPPSKRP---LSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV 1200
              +   +P  A   +  PP++ P   +SS S+ S +             GG +   S S+
Sbjct: 174  AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 233

Query: 1201 PK--WPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPP---------- 1248
                 P SS  R G  A G+     R PA    P+   L  ++ P   PP          
Sbjct: 234  SSSATPLSSPARSGPSARGT----PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP 289

Query: 1249 -GSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFST---TPMLSLRQRMMH 1304
              SSP A+  PS  P  SA    P   T P P  T   PP   +T   +P L      + 
Sbjct: 290  LSSSPLATPSPSAPPSPSA---PPSLQTLPSPPAT---PPSQATTSLGSPTLQATHSFLP 343

Query: 1305 ARFRNPLSRQP 1315
            +   +PL+  P
Sbjct: 344  SPPLSPLATPP 354



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 91/413 (22%), Positives = 138/413 (33%), Gaps = 54/413 (13%)

Query: 922  KEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPG--STDRHASPA 979
            ++P+ E     G  T P+    +  ++      S   +    +    PG  S+   AS  
Sbjct: 55   RKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGT 114

Query: 980  RPPAARSQQHPSVPRRMTPGRAPQQQPPPPVA--------TSQHHPGP-------QSRDA 1024
              P    Q+   +    T  R    + P   A        TS   PG        +SR A
Sbjct: 115  TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 174

Query: 1025 GRSPSQPRLSLTQAGRPRPTSQG--------RSHSSSDPYTASSRGMLPTALQNQDEDAQ 1076
            G     PR +   + RPRP ++G          HS+++P  A+ R   P+A       A 
Sbjct: 175  GTEVGLPRPA--PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR--PSAGGGLQRPAS 230

Query: 1077 GSYDDDSTEVEAQ---------DVRAPAHAARAKEAAASLPKHQQVESPT--GAGAGGDH 1125
             S    +T + +            RAPAH ++ K       +  QV  P    A A G  
Sbjct: 231  RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 290

Query: 1126 RSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDA 1185
             S      SP+ P  P  P S   +PS  A     PPS+   S  S    +         
Sbjct: 291  SSSPLATPSPSAPPSPSAPPSLQTLPSPPAT----PPSQATTSLGSPTLQATHS------ 340

Query: 1186 GFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPV---KR 1242
             F        L++  P+ P +      +      A     P    +P+  +   V   + 
Sbjct: 341  -FLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQA 399

Query: 1243 PLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPM 1295
            P  PPP    +A   P   PP S +   P            + PP   ++ PM
Sbjct: 400  PFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 452



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 92/365 (25%), Positives = 117/365 (32%), Gaps = 61/365 (16%)

Query: 475 PEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKI------LANGGAPRKPQLRAK 528
           P  + PS  AP     PS PASP    +          +      LA       P L   
Sbjct: 428 PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 487

Query: 529 KAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAP--------- 579
             + L        G+         PMSP  T        PP +    + AP         
Sbjct: 488 PLQALPSPPASFPGQAPFSPSASLPMSPLAT--------PPPQAPPVLAAPLLQVPPSPP 539

Query: 580 -GRTAVRARMPALPRRE-GVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPA 637
              T    R P  P  +  V  P  +LA  P P  PPS S S    +      H  S  +
Sbjct: 540 ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL-SGPDLAGHSSSATS 598

Query: 638 SLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPA 697
           +  +    DS  +  A  S  P    A   PA      +P    R      PGA    P 
Sbjct: 599 TPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGA----PGAPLPWPP 654

Query: 698 RRTPHSG-------AAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDA 750
              P S          E   SA+  P  L P                SP + GGK    A
Sbjct: 655 ATGPGSADGLCTIYETEGPESATPAPGALDPG--------------PSPGTSGGKAAAGA 700

Query: 751 PA-TNSNAPSRS--------TMSSSVSSHLSSRTQVSEGAE-ASDGESHGDGDREDGGRQ 800
            A  +S +P ++         + +SV  HL SRT +   AE A+ G   G G  E GG  
Sbjct: 701 GAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVT 760

Query: 801 AEATA 805
             A A
Sbjct: 761 GGARA 765


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
            [Homo sapiens]
          Length = 1412

 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 179/878 (20%), Positives = 298/878 (33%), Gaps = 148/878 (16%)

Query: 453  AMPTTSKADVEQNTEDNGKPEKPEPSSP----SPRAPASSQHPSVPASPQGRNAK--DLL 506
            A P+ +   V +  E+   P     + P    + +A +SS+  S  +       K  + +
Sbjct: 161  AEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKI 220

Query: 507  LDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTL 566
            L ++       G P K    A   +   + S    G+ E    EDS  S  ++ D +   
Sbjct: 221  LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPE----EDSESSSEESSDSEEET 276

Query: 567  RPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPS--ASASPAHHA 624
             P ++      A G+T+ +    + P +E            PR GA P+      PA   
Sbjct: 277  -PAAKALLQAKASGKTS-QVGAASAPAKES-----------PRKGAAPAPPGKTGPAVAK 323

Query: 625  STQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDR 684
            +  G     S  +S       +SD +E A     P G   Q R A +P+++SP       
Sbjct: 324  AQAGKREEDSQSSS------EESDSEEEAPAQAKPSGKAPQVRAASAPAKESP------- 370

Query: 685  SSVHPGAKPASPARRTPHS-----GAAEEDSSASAPPSRLS------------PPHGGSS 727
                 GA PA P +  P +     G  EEDS +S+  S                P G S 
Sbjct: 371  ---RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 427

Query: 728  RLLPTQPHLSSPLSKGG---KDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEAS 784
            ++ P       PL KG      G+  PAT S                    QV +  E S
Sbjct: 428  QVKPASTMGMGPLGKGAGPVPPGKVGPATPS-------------------AQVGKWEEDS 468

Query: 785  DGESHGDGDREDGG-RQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRL 843
            +  S    D  DG    A A AQ                             S+G   + 
Sbjct: 469  ESSSEESSDSSDGEVPTAVAPAQ---------------------------EKSLGNILQA 501

Query: 844  QPSSSPQSTVPSRAHP---RVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ 900
            +P+SSP    P +A P   +V +        SS    D  D +  PA +       + + 
Sbjct: 502  KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKI 561

Query: 901  PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLAS----KAQDVQQST 956
            P ++     + +    A +       + P+  G  T P G   ++A      A+D   S 
Sbjct: 562  PQTKACPK-KTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSE 620

Query: 957  DADTE----------GHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQP 1006
            ++D+E          G +     G   + AS     +      P +P +  P    Q + 
Sbjct: 621  ESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP-TVTQVKA 679

Query: 1007 PPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPT 1066
                 +        S +A  SP+Q + S+ +       +  R+ S+    +A  + +   
Sbjct: 680  EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 739

Query: 1067 ALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQ-VESPTGAGAGGDH 1125
            A   Q   ++      + +      R PA      +A A+  + Q   E  +G+      
Sbjct: 740  AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799

Query: 1126 RSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDA 1185
              +     +  +PS        A  P++ +P K   P+    +  S    +A+  +++D+
Sbjct: 800  SEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS----AAQAGKQDDS 855

Query: 1186 GFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLP 1245
            G          SSS       S   G   A  + A+  + P I + P      P   P  
Sbjct: 856  G----------SSS-----EESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ 900

Query: 1246 PPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTT 1283
                S+PR +   S    RS+++ S      P  Q  T
Sbjct: 901  AQAASTPRKARA-SESTARSSSSESEDEDVIPATQCLT 937



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 163/780 (20%), Positives = 275/780 (35%), Gaps = 121/780 (15%)

Query: 513  ILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKR--TLRPPS 570
            +L     P   Q++A+K E+ +    E   EE   S      S   TQ +      R PS
Sbjct: 665  VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 724

Query: 571  RHGHSVVAPGRTAVRA-----RMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
              G ++ APG+    A     R P+  +   V  P  S      P + PS   + A  A 
Sbjct: 725  AKG-TISAPGKVVTAAAQAKQRSPSKVKPP-VRNPQNSTVLARGPASVPSVGKAVATAAQ 782

Query: 626  TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRS 685
             Q      S     +  +  DS+E+   +  + P G   Q R AL+P+++SP        
Sbjct: 783  AQTGPEEDSG----SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP-------- 830

Query: 686  SVHPGAKPASPARRTPHSG-AAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL---- 740
                GA P  P +  P +  A ++D S S+  S  S   G +   + +   +  PL    
Sbjct: 831  --RKGAAPTPPGKTGPSAAQAGKQDDSGSS--SEESDSDGEAPAAVTSAQVIKPPLIFVD 886

Query: 741  ---SKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQ--------------------- 776
               S  G     A A  ++ P ++  S S +   SS ++                     
Sbjct: 887  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946

Query: 777  -------VSEGAEASDGESHGDGDR-EDGGRQAEATAQTLRARPASGHFHLLRHKPFAAN 828
                   ++  A  +   S  +  R  DG +Q     Q  +  PAS        K  A  
Sbjct: 947  MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLA-- 1004

Query: 829  GRSPSRFSIGRGP--RLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKP-L 885
                 + S  + P  R QPSS   S V +     +P+ S     + +   G  +  KP L
Sbjct: 1005 ----QKASEAQPPVARTQPSSGVDSAVGT-----LPATSPQSTSVQA--KGTNKLRKPKL 1053

Query: 886  PATVVNDHVPSSS-----RQPISRGWEDLRRSPQRGASLHR-KEPIPENPKSTGADTHPQ 939
            P        P SS         S G E+    PQ   S H    P P   ++   +T  +
Sbjct: 1054 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAE 1113

Query: 940  GKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPG 999
                 + + +Q +           S    PG T  + S A     +    PSV   +   
Sbjct: 1114 SSEDDVVAPSQSLL----------SGYMTPGLTPAN-SQASKATPKLDSSPSVSSTLAAK 1162

Query: 1000 RAP--QQQPPPPVATSQHHP--GPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSS-- 1053
              P  +Q+  P  A     P  G +   +G +P + R     AG P+ ++     + +  
Sbjct: 1163 DDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQC 1222

Query: 1054 ---DPY---TASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASL 1107
                P+    A  +  +   L    E  +    D + E   +   +        + AA  
Sbjct: 1223 LLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAART 1282

Query: 1108 PKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPL 1167
            P+ ++ +   GAG GG+       + SP + S     +++     +A+    E   K  L
Sbjct: 1283 PRSKK-KKKLGAGEGGE------ASVSPEKTSTTSKGKAKR---DKASGDVKEKKGKGSL 1332

Query: 1168 SSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPA 1227
             S+  +    E++ ++  G  +GG +   S+   K     + +  KD +    K++ + A
Sbjct: 1333 GSQGAKD-EPEEELQKGMGTVEGGDQ---SNPKSKKEKKKSDKRKKDKEKKEKKKKAKKA 1388



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 117/617 (18%), Positives = 207/617 (33%), Gaps = 93/617 (15%)

Query: 910  RRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQP 969
            +R  +  A+L  K+    +P ST   +  + +  +  +KA     ST++   G    +  
Sbjct: 62   KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 970  GSTDRHASPARPPAARSQQHPSVPR---RMTPGRAPQQQPPPPVATSQHHPGPQSRDAGR 1026
                +  +        S  HP+  +    +  G++P++   P   T+      ++ + G 
Sbjct: 122  KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS---ETEEEGS 178

Query: 1027 SPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEV 1086
             P+        A +P   S G++ SSS+  ++SS                     D T+V
Sbjct: 179  VPA-----FGAAAKPGMVSAGQADSSSEDTSSSS---------------------DETDV 212

Query: 1087 EAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQS 1146
            E +          A   A   P      +P G       +++ G     +  S      S
Sbjct: 213  EVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 272

Query: 1147 RARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSS 1206
                P+  A  +++   K   S     S  A++   + A     GK           P+ 
Sbjct: 273  EEETPAAKALLQAKASGK--TSQVGAASAPAKESPRKGAAPAPPGKTG---------PAV 321

Query: 1207 STPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSP--RASHVPSRLPPR 1264
            +  + GK  + S +  E   +   AP              P G +P  RA+  P++  PR
Sbjct: 322  AKAQAGKREEDSQSSSEESDSEEEAPAQAK----------PSGKAPQVRAASAPAKESPR 371

Query: 1265 SAATVSPVAGTHP---WPQYTTRAPPGHFSTTPMLSLRQRM--MHARFRNPLSRQP-ARP 1318
              A  +P   T P     Q   +      S+    S R+ +  M+A    PL + P  +P
Sbjct: 372  KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKP 431

Query: 1319 SYRQGY-----NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYL 1373
            +   G         P   GKV P +     G+   +    ++   D   G V  A     
Sbjct: 432  ASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ 491

Query: 1374 QDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKP 1433
            + S GN L+ K                  P   P  G  +   P+A      +     KP
Sbjct: 492  EKSLGNILQAK------------------PTSSPAKGPPQKAGPVA------VQVKAEKP 527

Query: 1434 LVGLEVIKKTTHPPTTTMQPT--TTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTV 1491
            +   E  ++++    +   P   T     P    P+ T A  ++T TT            
Sbjct: 528  MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQ-TKACPKKTNTTASAKVAPVRVGT 586

Query: 1492 RTTTRTTTTTTPTPTTP 1508
            +   +  T T+P  ++P
Sbjct: 587  QAPRKAGTATSPAGSSP 603


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
            sapiens]
          Length = 1411

 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 179/878 (20%), Positives = 298/878 (33%), Gaps = 148/878 (16%)

Query: 453  AMPTTSKADVEQNTEDNGKPEKPEPSSP----SPRAPASSQHPSVPASPQGRNAK--DLL 506
            A P+ +   V +  E+   P     + P    + +A +SS+  S  +       K  + +
Sbjct: 161  AEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKI 220

Query: 507  LDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTL 566
            L ++       G P K    A   +   + S    G+ E    EDS  S  ++ D +   
Sbjct: 221  LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPE----EDSESSSEESSDSEEET 276

Query: 567  RPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPS--ASASPAHHA 624
             P ++      A G+T+ +    + P +E            PR GA P+      PA   
Sbjct: 277  -PAAKALLQAKASGKTS-QVGAASAPAKES-----------PRKGAAPAPPGKTGPAVAK 323

Query: 625  STQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDR 684
            +  G     S  +S       +SD +E A     P G   Q R A +P+++SP       
Sbjct: 324  AQAGKREEDSQSSS------EESDSEEEAPAQAKPSGKAPQVRAASAPAKESP------- 370

Query: 685  SSVHPGAKPASPARRTPHS-----GAAEEDSSASAPPSRLS------------PPHGGSS 727
                 GA PA P +  P +     G  EEDS +S+  S                P G S 
Sbjct: 371  ---RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 427

Query: 728  RLLPTQPHLSSPLSKGG---KDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEAS 784
            ++ P       PL KG      G+  PAT S                    QV +  E S
Sbjct: 428  QVKPASTMGMGPLGKGAGPVPPGKVGPATPS-------------------AQVGKWEEDS 468

Query: 785  DGESHGDGDREDGG-RQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRL 843
            +  S    D  DG    A A AQ                             S+G   + 
Sbjct: 469  ESSSEESSDSSDGEVPTAVAPAQ---------------------------EKSLGNILQA 501

Query: 844  QPSSSPQSTVPSRAHP---RVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ 900
            +P+SSP    P +A P   +V +        SS    D  D +  PA +       + + 
Sbjct: 502  KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKI 561

Query: 901  PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLAS----KAQDVQQST 956
            P ++     + +    A +       + P+  G  T P G   ++A      A+D   S 
Sbjct: 562  PQTKACPK-KTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSE 620

Query: 957  DADTE----------GHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQP 1006
            ++D+E          G +     G   + AS     +      P +P +  P    Q + 
Sbjct: 621  ESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP-TVTQVKA 679

Query: 1007 PPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPT 1066
                 +        S +A  SP+Q + S+ +       +  R+ S+    +A  + +   
Sbjct: 680  EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 739

Query: 1067 ALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQ-VESPTGAGAGGDH 1125
            A   Q   ++      + +      R PA      +A A+  + Q   E  +G+      
Sbjct: 740  AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799

Query: 1126 RSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDA 1185
              +     +  +PS        A  P++ +P K   P+    +  S    +A+  +++D+
Sbjct: 800  SEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS----AAQAGKQDDS 855

Query: 1186 GFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLP 1245
            G          SSS       S   G   A  + A+  + P I + P      P   P  
Sbjct: 856  G----------SSS-----EESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ 900

Query: 1246 PPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTT 1283
                S+PR +   S    RS+++ S      P  Q  T
Sbjct: 901  AQAASTPRKARA-SESTARSSSSESEDEDVIPATQCLT 937



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 163/779 (20%), Positives = 275/779 (35%), Gaps = 120/779 (15%)

Query: 513  ILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKR--TLRPPS 570
            +L     P   Q++A+K E+ +    E   EE   S      S   TQ +      R PS
Sbjct: 665  VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 724

Query: 571  RHGHSVVAPGRTAVRA-----RMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
              G ++ APG+    A     R P+  +   V  P  S      P + PS   + A  A 
Sbjct: 725  AKG-TISAPGKVVTAAAQAKQRSPSKVKPP-VRNPQNSTVLARGPASVPSVGKAVATAAQ 782

Query: 626  TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRS 685
             Q      S     +  +  DS+E+   +  + P G   Q R AL+P+++SP        
Sbjct: 783  AQTGPEEDSG----SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP-------- 830

Query: 686  SVHPGAKPASPARRTPHSG-AAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL---- 740
                GA P  P +  P +  A ++D S S+  S  S   G +   + +   +  PL    
Sbjct: 831  --RKGAAPTPPGKTGPSAAQAGKQDDSGSS--SEESDSDGEAPAAVTSAQVIKPPLIFVD 886

Query: 741  ---SKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQ--------------------- 776
               S  G     A A  ++ P ++  S S +   SS ++                     
Sbjct: 887  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946

Query: 777  -------VSEGAEASDGESHGDGDR-EDGGRQAEATAQTLRARPASGHFHLLRHKPFAAN 828
                   ++  A  +   S  +  R  DG +Q     Q  +  PAS        K  A  
Sbjct: 947  MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLA-- 1004

Query: 829  GRSPSRFSIGRGP--RLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKP-L 885
                 + S  + P  R QPSS   S V +     +P+ S     + +   G  +  KP L
Sbjct: 1005 ----QKASEAQPPVARTQPSSGVDSAVGT-----LPATSPQSTSVQA--KGTNKLRKPKL 1053

Query: 886  PATVVNDHVPSSS-----RQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQG 940
            P        P SS         S G E+    PQ   S H   P P   ++   +T  + 
Sbjct: 1054 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES 1113

Query: 941  KYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGR 1000
                + + +Q +           S    PG T  + S A     +    PSV   +    
Sbjct: 1114 SEDDVVAPSQSLL----------SGYMTPGLTPAN-SQASKATPKLDSSPSVSSTLAAKD 1162

Query: 1001 AP--QQQPPPPVATSQHHP--GPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSS--- 1053
             P  +Q+  P  A     P  G +   +G +P + R     AG P+ ++     + +   
Sbjct: 1163 DPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCL 1222

Query: 1054 --DPY---TASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLP 1108
               P+    A  +  +   L    E  +    D + E   +   +        + AA  P
Sbjct: 1223 LGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTP 1282

Query: 1109 KHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLS 1168
            + ++ +   GAG GG+       + SP + S     +++     +A+    E   K  L 
Sbjct: 1283 RSKK-KKKLGAGEGGE------ASVSPEKTSTTSKGKAKR---DKASGDVKEKKGKGSLG 1332

Query: 1169 SKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPA 1227
            S+  +    E++ ++  G  +GG +   S+   K     + +  KD +    K++ + A
Sbjct: 1333 SQGAKD-EPEEELQKGMGTVEGGDQ---SNPKSKKEKKKSDKRKKDKEKKEKKKKAKKA 1387



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 117/617 (18%), Positives = 207/617 (33%), Gaps = 93/617 (15%)

Query: 910  RRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQP 969
            +R  +  A+L  K+    +P ST   +  + +  +  +KA     ST++   G    +  
Sbjct: 62   KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121

Query: 970  GSTDRHASPARPPAARSQQHPSVPR---RMTPGRAPQQQPPPPVATSQHHPGPQSRDAGR 1026
                +  +        S  HP+  +    +  G++P++   P   T+      ++ + G 
Sbjct: 122  KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS---ETEEEGS 178

Query: 1027 SPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEV 1086
             P+        A +P   S G++ SSS+  ++SS                     D T+V
Sbjct: 179  VPA-----FGAAAKPGMVSAGQADSSSEDTSSSS---------------------DETDV 212

Query: 1087 EAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQS 1146
            E +          A   A   P      +P G       +++ G     +  S      S
Sbjct: 213  EVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 272

Query: 1147 RARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSS 1206
                P+  A  +++   K   S     S  A++   + A     GK           P+ 
Sbjct: 273  EEETPAAKALLQAKASGK--TSQVGAASAPAKESPRKGAAPAPPGKTG---------PAV 321

Query: 1207 STPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSP--RASHVPSRLPPR 1264
            +  + GK  + S +  E   +   AP              P G +P  RA+  P++  PR
Sbjct: 322  AKAQAGKREEDSQSSSEESDSEEEAPAQAK----------PSGKAPQVRAASAPAKESPR 371

Query: 1265 SAATVSPVAGTHP---WPQYTTRAPPGHFSTTPMLSLRQRM--MHARFRNPLSRQP-ARP 1318
              A  +P   T P     Q   +      S+    S R+ +  M+A    PL + P  +P
Sbjct: 372  KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKP 431

Query: 1319 SYRQGY-----NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYL 1373
            +   G         P   GKV P +     G+   +    ++   D   G V  A     
Sbjct: 432  ASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ 491

Query: 1374 QDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKP 1433
            + S GN L+ K                  P   P  G  +   P+A      +     KP
Sbjct: 492  EKSLGNILQAK------------------PTSSPAKGPPQKAGPVA------VQVKAEKP 527

Query: 1434 LVGLEVIKKTTHPPTTTMQPT--TTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTV 1491
            +   E  ++++    +   P   T     P    P+ T A  ++T TT            
Sbjct: 528  MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQ-TKACPKKTNTTASAKVAPVRVGT 586

Query: 1492 RTTTRTTTTTTPTPTTP 1508
            +   +  T T+P  ++P
Sbjct: 587  QAPRKAGTATSPAGSSP 603


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 59/151 (39%), Positives = 65/151 (43%), Gaps = 23/151 (15%)

Query: 1443 TTHPPTTTMQ--PTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTT- 1499
            TT PPTTT    PTTTTTP PTTT   PTT T    T T  TTT  PTTT    T TTT 
Sbjct: 1554 TTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTIT--TTTPPPTTTPSPPTTTTTT 1611

Query: 1500 ---TTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLET--DTAVPT 1554
               TTTP+P T  P  PP              S+  +P         +   T   T  P+
Sbjct: 1612 PPPTTTPSPPTTTPITPP-------------TSTTTLPPTTTPSPPPTTTTTPPPTTTPS 1658

Query: 1555 EEAYVIYDEDYEFETSRPPTTTEPSTTATTP 1585
                          T+ PPTTT  S   TTP
Sbjct: 1659 PPTTTTPSPPITTTTTPPPTTTPSSPITTTP 1689



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 45/89 (50%), Positives = 50/89 (56%), Gaps = 17/89 (19%)

Query: 1443 TTHPPTTTMQPTTTTTPLP---TTTTPRPTTATTRRTTTT-----RRTTTRRPTTT---- 1490
            TT PPTTT  P TTTTP P   TTTTP PTT  +   TTT        TT  PTTT    
Sbjct: 1649 TTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSP 1708

Query: 1491 VRTTTRTTTTTTPTP-----TTPIPTCPP 1514
            + TTT  ++TTTP+P     TTP PT  P
Sbjct: 1709 ITTTTTPSSTTTPSPPPTTMTTPSPTTTP 1737



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 68/213 (31%), Positives = 78/213 (36%), Gaps = 29/213 (13%)

Query: 1440 IKKTTHPPTTTMQ-PTTTTTPLPTTTTPRPTTAT-----TRRTTTTRRTTTRRPTTTVRT 1493
            I  TT PPTTT   PTTTTT  P TTTP P T T     T  TT    TT   P TT  T
Sbjct: 1591 ITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTT 1650

Query: 1494 TTRTTTTTTPTPTTPIP-----TCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLET 1548
               TTT + PT TTP P     T PP T             S+ I    +         +
Sbjct: 1651 PPPTTTPSPPTTTTPSPPITTTTTPPPT----------TTPSSPITTTPSPPTTTMTTPS 1700

Query: 1549 DTAVPTEEAYVIYDEDYEFETSRPPT-------TTEPSTTATTPRVIPEEGAISSFPEEE 1601
             T  P+               S PPT       TT PS   TT   +P     S      
Sbjct: 1701 PTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTP 1760

Query: 1602 FDLAGRKRFVAPYVTYLNKDPSAP-CSLTDALD 1633
               +      +P+ T     P  P C+ T  LD
Sbjct: 1761 LPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLD 1793



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 56/154 (36%), Positives = 63/154 (40%), Gaps = 14/154 (9%)

Query: 1443 TTHPPTTTMQP-TTTTTPLPTTTTPRPTTAT-----TRRTTTTRRTTTRRPTTTVRTTTR 1496
            TT PPTTT  P TTTTT  P TTTP P T T     T  TT    TT   P TT  T   
Sbjct: 1515 TTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPP 1574

Query: 1497 TTTTTTPTPTTPIP-----TCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTA 1551
            TTT + PT TTP P     T PP T            ++   P         + +   T+
Sbjct: 1575 TTTPSPPTTTTPSPPTITTTTPPPTT---TPSPPTTTTTTPPPTTTPSPPTTTPITPPTS 1631

Query: 1552 VPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTP 1585
              T              T+ PPTTT    T TTP
Sbjct: 1632 TTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTP 1665



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 60/159 (37%), Positives = 65/159 (40%), Gaps = 18/159 (11%)

Query: 1443 TTHPPTTTMQPT-TTTTPLPTTTTPRP--TTATTRRTTTT-----RRTTTRRPTTT---- 1490
            T  PPTTT  P  T+TT LP TTTP P  TT TT   TTT       TTT  PTTT    
Sbjct: 1398 TPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPP 1457

Query: 1491 VRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
            + TTT    TTTP+P T  P+ PP T                 P             T T
Sbjct: 1458 ISTTTTPPPTTTPSPPTTTPS-PPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTT 1516

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              PT              T+ PP TT PS   TTP   P
Sbjct: 1517 LPPTTT-----PSPPTTTTTTPPPTTTPSPPTTTPITPP 1550



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 58/162 (35%), Positives = 64/162 (39%), Gaps = 39/162 (24%)

Query: 1443 TTHPPTTTMQPTTTT--------TPLPTTTTPRP--TTATTRRTTTTRRTTTRRPTTTVR 1492
            TT PPTTT  P TTT        T LP TTTP P  TT TT   TTT    T  P T   
Sbjct: 1492 TTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPT 1551

Query: 1493 TTTRTTTTTTPTP-----TTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLE 1547
            +TT    TTTP+P     TTP PT  P            I ++   P             
Sbjct: 1552 STTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPP------------T 1599

Query: 1548 TDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
            T  + PT              T+ PP TT PS   TTP   P
Sbjct: 1600 TTPSPPTT------------TTTTPPPTTTPSPPTTTPITPP 1629



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 55/152 (36%), Positives = 63/152 (41%), Gaps = 23/152 (15%)

Query: 1444 THPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
            T P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 1894 TPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 1952

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 1953 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 1996

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 1997 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2028



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 1985 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2043

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2044 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2087

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2088 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2120



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2077 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2135

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2136 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2179

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2180 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2212



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2169 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2227

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2228 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2271

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2272 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2304



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2261 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2319

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2320 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2363

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2364 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2396



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2353 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2411

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2412 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2455

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2456 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2488



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2445 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2503

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2504 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2547

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2548 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2580



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2537 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2595

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2596 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2639

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2640 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2672



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2629 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2687

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2688 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2731

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2732 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2764



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2721 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2779

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2780 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2823

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2824 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2856



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2813 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2871

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2872 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 2915

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 2916 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2948



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2905 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 2963

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 2964 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3007

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3008 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3040



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 2997 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3055

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3056 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3099

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3100 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3132



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3089 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3147

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3148 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3191

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3192 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3224



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3181 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3239

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3240 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3283

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3284 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3316



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3273 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3331

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3332 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3375

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3376 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3408



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3365 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3423

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3424 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3467

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3468 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3500



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3457 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3515

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3516 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3559

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3560 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3592



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3549 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3607

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3608 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3651

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3652 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3684



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3641 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3699

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3700 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3743

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3744 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3776



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3733 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3791

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3792 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3835

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3836 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3868



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3825 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3883

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3884 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 3927

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 3928 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3960



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 3917 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 3975

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 3976 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 4019

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 4020 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4052



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/153 (35%), Positives = 63/153 (41%), Gaps = 23/153 (15%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 4009 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 4067

Query: 1498 TTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEE 1556
            T T TPTPT T  PT  P T           ++    P         +G +T T  P   
Sbjct: 4068 TVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITT 4111

Query: 1557 AYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
               +        T  P TT   +TT  TP   P
Sbjct: 4112 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4144



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 61/168 (36%), Positives = 70/168 (41%), Gaps = 26/168 (15%)

Query: 1443 TTHPPTTTMQP--TTTTTPLPTTTTPRPTTATTRRTTT----TRRTTTRRPTTTVRTTTR 1496
            TT PPTTT  P  +TTTTP PTTT   PTT  +  TTT    T  TTT  PTTT    T 
Sbjct: 1446 TTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPT- 1504

Query: 1497 TTTTTTPTPTTPIP------------TCPPGTLERHDDDGNLI---MSSNGIPECYAEED 1541
            TT  T P  TT +P            T PP T          I    S+  +P       
Sbjct: 1505 TTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSP 1564

Query: 1542 EFSGLET--DTAVPTEEAYVIYDEDYEFETSRPPTTT--EPSTTATTP 1585
              +   T   T  P+              T+ PPTTT   P+TT TTP
Sbjct: 1565 PPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTP 1612



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 1910 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 1969

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 1970 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2012

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2013 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2051



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2002 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2061

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2062 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2104

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2105 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2143



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2094 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2153

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2154 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2196

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2197 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2235



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2186 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2245

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2246 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2288

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2289 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2327



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2278 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2337

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2338 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2380

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2381 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2419



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2370 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2429

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2430 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2472

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2473 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2511



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2462 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2521

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2522 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2564

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2565 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2603



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2554 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2613

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2614 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2656

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2657 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2695



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2646 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2705

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2706 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2748

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2749 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2787



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2738 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2797

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2798 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2840

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2841 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2879



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2830 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2889

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2890 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 2932

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 2933 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2971



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 2922 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2981

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 2982 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3024

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3025 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3063



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3014 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3073

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3074 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3116

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3117 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3155



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3106 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3165

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3166 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3208

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3209 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3247



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3198 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3257

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3258 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3300

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3301 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3339



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3290 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3349

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3350 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3392

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3393 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3431



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3382 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3441

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3442 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3484

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3485 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3523



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3474 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3533

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3534 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3576

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3577 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3615



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3566 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3625

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3626 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3668

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3669 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3707



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3658 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3717

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3718 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3760

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3761 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3799



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3750 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3809

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3810 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3852

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3853 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3891



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3842 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3901

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3902 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 3944

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 3945 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3983



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 3934 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3993

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 3994 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 4036

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 4037 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4075



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 55/159 (34%), Positives = 63/159 (39%), Gaps = 30/159 (18%)

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTT------------TRRPTTTV 1491
            T  PT T  PTTT     TT TP PT   T+  TTT  TT            T+ PTTT 
Sbjct: 4026 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4085

Query: 1492 RTTTRTTTTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT 1550
             TTT TT T TPTPT T  PT  P T           ++    P         +G +T T
Sbjct: 4086 ITTT-TTVTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPT 4128

Query: 1551 AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              P      +        T  P TT   +TT  TP   P
Sbjct: 4129 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4167



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 1909 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 1963

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 1964 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 2021

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 2022 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 2065

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 2066 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2097



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 1978 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 2032

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 2033 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 2090

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 2091 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 2134

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 2135 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2166



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 2185 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 2239

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 2240 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 2297

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 2298 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 2341

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 2342 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2373



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 2254 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 2308

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 2309 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 2366

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 2367 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 2410

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 2411 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2442



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 2461 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 2515

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 2516 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 2573

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 2574 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 2617

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 2618 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2649



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 2530 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 2584

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 2585 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 2642

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 2643 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 2686

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 2687 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2718



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 2737 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 2791

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 2792 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 2849

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 2850 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 2893

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 2894 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2925



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 2806 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 2860

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 2861 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 2918

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 2919 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 2962

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 2963 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2994



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 3013 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 3067

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 3068 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 3125

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 3126 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 3169

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 3170 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3201



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 3082 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 3136

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 3137 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 3194

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 3195 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 3238

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 3239 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3270



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 3289 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 3343

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 3344 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 3401

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 3402 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 3445

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 3446 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3477



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 3358 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 3412

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 3413 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 3470

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 3471 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 3514

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 3515 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3546



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 3565 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 3619

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 3620 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 3677

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 3678 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 3721

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 3722 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3753



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 3634 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 3688

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 3689 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 3746

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 3747 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 3790

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 3791 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3822



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 3841 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 3895

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 3896 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 3953

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 3954 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 3997

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 3998 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4029



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/212 (30%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 1380 PLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPL-VGLE 1438
            P     G    T   +  T  V+P   P   Q    TP+         ++   P   G +
Sbjct: 3910 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT-----TVTPTPTPTGTQ 3964

Query: 1439 VIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTT 1498
                T    TTT+ PT T T   T TT  P T TT  T T   T T+ PTTT  TTT TT
Sbjct: 3965 TPTTTPITTTTTVTPTPTPTGTQTPTT-TPITTTTTVTPTPTPTGTQTPTTTPITTT-TT 4022

Query: 1499 TTTTPTPT-TPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEA 1557
             T TPTPT T  PT  P T           ++    P         +G +T T  P    
Sbjct: 4023 VTPTPTPTGTQTPTTTPITT-------TTTVTPTPTP---------TGTQTPTTTPITTT 4066

Query: 1558 YVIYDEDYEFETSRPPTTTEPSTTATTPRVIP 1589
              +        T  P TT   +TT  TP   P
Sbjct: 4067 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4098



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 63/186 (33%), Positives = 79/186 (42%), Gaps = 37/186 (19%)

Query: 1443 TTHPPTTTMQPTTTTTPLPT-----TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRT 1497
            T  P TT +  TTT TP PT     T T  P T TT  T T   T T+ PTTT  TTT T
Sbjct: 4101 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-T 4159

Query: 1498 TTTTTPTPT----------------TPIPTCPPGTL---ERHDDDGNL--IMSSNGIPEC 1536
            T T TPTPT                TP PT P GT      H     +  + +SN  PE 
Sbjct: 4160 TVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTGTQTGPPTHTSTAPIAELTTSNPPPES 4218

Query: 1537 YAEEDEFSGLETDTAVPTEEAYVIYD---EDYEFETSRPPTT-TEPSTTATTPRVIPEEG 1592
               +   S     T+ P  E+  +        E  ++ PP+T T P+TT+    + P   
Sbjct: 4219 STPQTSRS-----TSSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPS 4273

Query: 1593 AISSFP 1598
              +S P
Sbjct: 4274 TTTSPP 4279



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 53/149 (35%), Positives = 61/149 (40%), Gaps = 23/149 (15%)

Query: 1448 TTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTT----VRTTTRTTTTTTP 1503
            TT   PTTT +P PT+TT  P T T    TTT  TTT  PTTT    + TTT    TTTP
Sbjct: 1397 TTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTT--TTTPPPTTTPSPPITTTTTPPPTTTP 1454

Query: 1504 TP-----TTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAY 1558
            +P     TTP PT  P              S                  T T +    + 
Sbjct: 1455 SPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPAS- 1513

Query: 1559 VIYDEDYEFETSRPPTTT--EPSTTATTP 1585
                      T+ PPTTT   P+TT TTP
Sbjct: 1514 ---------TTTLPPTTTPSPPTTTTTTP 1533



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 46/148 (31%), Positives = 63/148 (42%), Gaps = 8/148 (5%)

Query: 1443 TTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTT 1502
            +T PP+T   PTTT+     T +P P+T T+   T TR TTT   +    +T +TTTT+ 
Sbjct: 4249 STAPPSTPTAPTTTSGG--HTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSA 4306

Query: 1503 PTPTTPIPTCPPGTLE----RHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAY 1558
             TP TP P   P  +     R      LI            E+ ++G   DT      + 
Sbjct: 4307 WTP-TPTPLSTPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEEVYNGTYGDTCYFVNCSL 4365

Query: 1559 VIYDEDYEFE-TSRPPTTTEPSTTATTP 1585
                E Y +   S P  T  PS +  TP
Sbjct: 4366 SCTLEFYNWSCPSTPSPTPTPSKSTPTP 4393



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 23/42 (54%), Positives = 26/42 (61%), Gaps = 1/42 (2%)

Query: 1472 TTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCP 1513
            TTR +T T  TT   PTT    TT TTTTTTPT +T + T P
Sbjct: 1259 TTRPSTLTTFTTITLPTTPTTFTT-TTTTTTPTSSTVLSTTP 1299



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 24/47 (51%), Positives = 26/47 (55%), Gaps = 7/47 (14%)

Query: 1443 TTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTT 1489
            TT P T T   T TT  LPTT    PTT TT  TTTT  ++T   TT
Sbjct: 1259 TTRPSTLT---TFTTITLPTT----PTTFTTTTTTTTPTSSTVLSTT 1298



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 22/66 (33%), Positives = 27/66 (40%), Gaps = 10/66 (15%)

Query: 1236 SLAPVKRPLPP-------PPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPG 1288
            +L P   P PP       PP ++P         PP S  T+ P     P P  TT  PP 
Sbjct: 1516 TLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPP- 1574

Query: 1289 HFSTTP 1294
              +TTP
Sbjct: 1575 --TTTP 1578



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 19/56 (33%), Positives = 23/56 (41%), Gaps = 3/56 (5%)

Query: 1239 PVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTP 1294
            P      PPP ++P         PP S  T+ P     P P  TT  PP   +TTP
Sbjct: 1605 PTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPP---TTTP 1657



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/66 (31%), Positives = 27/66 (40%), Gaps = 7/66 (10%)

Query: 1236 SLAPVKRPLPPP-------PGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPG 1288
            +L P   P PPP       P ++P      +  PP +  T  P   T   P  TT +PP 
Sbjct: 1634 TLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPT 1693

Query: 1289 HFSTTP 1294
               TTP
Sbjct: 1694 TTMTTP 1699



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 18/60 (30%), Positives = 25/60 (41%), Gaps = 4/60 (6%)

Query: 1239 PVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSL 1298
            P+       P  +P  +  P+  P  +  TV+P     P P  T   PP H ST P+  L
Sbjct: 4154 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT----PTPTGTQTGPPTHTSTAPIAEL 4209



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 3/60 (5%)

Query: 1236 SLAPVKRPLPPPPGSS-PRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTP 1294
            +L P   P PPP  ++ P  +  PS  PP +     P   T   P  TT +PP   +TTP
Sbjct: 1555 TLPPTTTPSPPPTTTTTPPPTTTPS--PPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTP 1612



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/63 (30%), Positives = 26/63 (41%), Gaps = 7/63 (11%)

Query: 1239 PVKRPLPP-------PPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFS 1291
            P   P PP       PP ++P      +  PP +     P+  T   P  TT +PP   +
Sbjct: 1402 PTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTT 1461

Query: 1292 TTP 1294
            TTP
Sbjct: 1462 TTP 1464



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 43/166 (25%), Positives = 63/166 (37%), Gaps = 37/166 (22%)

Query: 1450 TMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPI 1509
            T +P+T TT    TT   PTT TT   TTT  TTT   +T + TT +     +       
Sbjct: 1259 TTRPSTLTT---FTTITLPTTPTT--FTTTTTTTTPTSSTVLSTTPKLCCLWSDWINEDH 1313

Query: 1510 PTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLE---TDTAVPTEEAYVIYDED-- 1564
            P+      +R   DG  +  +    EC + +D    LE             ++  +ED  
Sbjct: 1314 PSSGSDDGDRETFDG--VCGAPEDIECRSVKDPHLSLEQLGQKVQCDVSVGFICKNEDQF 1371

Query: 1565 --------YEFE--------------TSRPPTTT---EPSTTATTP 1585
                    Y+++              T  PPTTT    P++T T P
Sbjct: 1372 GNGPFGLCYDYKIRVNCCWPMDKCITTPSPPTTTPSPPPTSTTTLP 1417



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 18/56 (32%), Positives = 25/56 (44%), Gaps = 2/56 (3%)

Query: 1239 PVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTP 1294
            P+     PPP ++P      +  PP +     P   T P P  TT +PP   +TTP
Sbjct: 1441 PITTTTTPPPTTTPSPPISTTTTPPPTTTPSPPT--TTPSPPTTTPSPPTTTTTTP 1494



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 10/66 (15%)

Query: 1236 SLAPVKRPLPP-------PPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPG 1288
            +L P   P PP       PP ++P      +  PP +     P++ T   P  TT +PP 
Sbjct: 1415 TLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPP- 1473

Query: 1289 HFSTTP 1294
              +TTP
Sbjct: 1474 --TTTP 1477



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 5/61 (8%)

Query: 1239 PVKRPLPPPPGSSPRASHVPSRLP-----PRSAATVSPVAGTHPWPQYTTRAPPGHFSTT 1293
            P   P PP    SP  +   +  P     P +   ++P A T   P  TT +PP   +TT
Sbjct: 1473 PTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTT 1532

Query: 1294 P 1294
            P
Sbjct: 1533 P 1533



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 20/62 (32%), Positives = 25/62 (40%), Gaps = 6/62 (9%)

Query: 1239 PVKRPLPP------PPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFST 1292
            P   P PP      PP S+       +  PP +  T  P   T   P  TT +PP   +T
Sbjct: 1535 PTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTT 1594

Query: 1293 TP 1294
            TP
Sbjct: 1595 TP 1596


>gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapiens]
          Length = 673

 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 163/745 (21%), Positives = 259/745 (34%), Gaps = 126/745 (16%)

Query: 566  LRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS 625
            + PP+R   S  +P RT   A +   P R  +     + +    P         P   AS
Sbjct: 1    MAPPTRTP-SRASPTRTPSTASLTGTPSRASLTGTPSTASLMGTPSRASLTGTPP--RAS 57

Query: 626  TQGTSHRPSLPAS--------LNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQ-S 676
             +GT+   SL  S        +  + L+       ++  + P+ +  +  P  S  R+ S
Sbjct: 58   LKGTTSMASLMVSPSRASLTRMQSSSLLTRTPSMASLKRMPPRASRTRTLPRASLMRRPS 117

Query: 677  PSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLS---PPHGGSSRLLPTQ 733
             +S+ R  S       P+  +     S AA     A   PSR S    P   S  + P+ 
Sbjct: 118  TASLTRSPSRASLTTTPSRASLSMTPSTAA-----ALTMPSRASLTRTPPRASLTMTPST 172

Query: 734  PHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGD 793
              L+    +    G  +  + +  PS ++++   S+   +RT        +   +   G 
Sbjct: 173  ASLTRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGS 232

Query: 794  REDGG-RQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQST 852
                      +TA  +R  P +    +L         +  S  SI R P    ++SP  T
Sbjct: 233  PPRASLSMMPSTALLIRTPPRASPTGMLSRTSLT---KMDSTASITRTPSRPSTASPTGT 289

Query: 853  VPSRAH----PRVPSHSDSHPKLS-SGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWE 907
             PSRA     P   S     P+ S +G+       K        D   S SR P      
Sbjct: 290  -PSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKM-------DSTASISRTPPRAS-- 339

Query: 908  DLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKA 967
             + R+P R +   +  P   +P  T +   P G  S+    A     S+ A   G  P+A
Sbjct: 340  -ITRTPSRASPTGK--PSTASPTGTPSRASPTGSPST----ASLTGLSSTASPTGTPPRA 392

Query: 968  QPGSTDRHASPARPPAARS------------QQHPSVPRRMTPGRAPQQQPPPPVATSQH 1015
             P  T   AS  R P   S                + P R  P  +P   PP        
Sbjct: 393  SPTGTPSTASLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPP-------- 444

Query: 1016 HPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDA 1075
               P    +  SP+  + + +  G P   S   S S++ P  + SR  L           
Sbjct: 445  RASPTGTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASL----------- 493

Query: 1076 QGSYDDDSTEVEAQDVRAPAHAARAK-EAAASLPKHQQVESPTGAGAGGDHRSQRGHAAS 1134
                            R P+ A+  K E+ AS+ +     SPT   +          A +
Sbjct: 494  ---------------TRTPSRASLTKMESTASITRTPSRASPTWTPSTASPTGSPSTALA 538

Query: 1135 PARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKED 1194
               PSR     +  R PSRA+   +  PS+  L++ S+ S++                  
Sbjct: 539  MGSPSR----AALTRTPSRAS--LTRTPSRASLTTPSRASLTRTPS-------------- 578

Query: 1195 LLSSSVPKWPSSSTPRG--------GKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPP 1246
              +  + + P S++P G        G  +   L K +   +I   P   S      P   
Sbjct: 579  --TVLLTRMPPSASPTGMPSRTSPTGMPSSALLTKMDSTASITRTPPRASPTETP-PRAS 635

Query: 1247 PPGSSPRASHVPSRLPPRSAATVSP 1271
            P G+ PRAS  P+  PPR++ T +P
Sbjct: 636  PTGTPPRAS--PTGTPPRASPTGTP 658



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 130/598 (21%), Positives = 194/598 (32%), Gaps = 92/598 (15%)

Query: 410 SLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDN 469
           SL+    T +AL     P    L +        + P + +     P  S   +   T   
Sbjct: 138 SLSMTPSTAAALT---MPSRASLTRTPPRASLTMTPSTASLTRTPPRASPTGMPSRTSPT 194

Query: 470 GKPE-----KPEPSSPSPRAPASSQHPSVP--ASPQGRNAKDLLLDLKNKILANGGAPRK 522
           G P      K + ++   R  + +     P  ASP G   +  L  + +  L     PR 
Sbjct: 195 GMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRA 254

Query: 523 PQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRT 582
                       L  T +T  +   S   +P  PS         R       S  +  R 
Sbjct: 255 SPTGM-------LSRTSLTKMDSTASITRTPSRPSTASPTGTPSRASLSMTPSTASLMRM 307

Query: 583 AVRARMPALPRREGVDKPGFSLA---TQPRPGAPPSAS-ASPAHHASTQ---GTSHRPSL 635
             RA    +  R  + K   + +   T PR     + S ASP    ST    GT  R S 
Sbjct: 308 LPRASPTGMLSRTSLTKMDSTASISRTPPRASITRTPSRASPTGKPSTASPTGTPSRASP 367

Query: 636 PASLNDNDLVDSDEDERAVGS---LHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAK 692
             S +   L          G+     P G  +       P R SP+ +L  R+S+     
Sbjct: 368 TGSPSTASLTGLSSTASPTGTPPRASPTGTPSTASLTRKPPRASPTGML-SRTSITKMDS 426

Query: 693 PASPARRTPHSGAAEEDSSAS--APPSRLSPPHGGSSRLLPT-QPHLSSPL---SKGGKD 746
            ASP R  P +        AS    PSR SP  G  S   PT  P  +SP    S     
Sbjct: 427 TASPTRTPPRASPTGTPPRASPTGTPSRASPT-GTQSTASPTGSPSTASPTGSPSTASPT 485

Query: 747 GEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQ 806
           G  + A+ +  PSR++++   S+   +RT        +   +   G           +  
Sbjct: 486 GSPSRASLTRTPSRASLTKMESTASITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRA 545

Query: 807 TLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGP------RLQPSSSPQSTVPSRAHPR 860
            L   P+      L   P  A+  +PSR S+ R P      R+ PS+SP   +PSR  P 
Sbjct: 546 ALTRTPSRAS---LTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSASPTG-MPSRTSPT 601

Query: 861 VPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLH 920
                                            +PSS+          + R+P       
Sbjct: 602 --------------------------------GMPSSALLTKMDSTASITRTP------- 622

Query: 921 RKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASP 978
                   P+++  +T P+   +    +A        A   G  P+A P  T   ASP
Sbjct: 623 --------PRASPTETPPRASPTGTPPRASPTGTPPRASPTGTPPRASPTGTPSRASP 672



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 146/614 (23%), Positives = 206/614 (33%), Gaps = 101/614 (16%)

Query: 913  PQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGST 972
            P R  S       P     TG  T  +   +   S A  +   + A   G  P+A    T
Sbjct: 4    PTRTPSRASPTRTPSTASLTG--TPSRASLTGTPSTASLMGTPSRASLTGTPPRASLKGT 61

Query: 973  DRHAS----PARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSP 1028
               AS    P+R    R Q    + R  TP  A  ++ PP               A R+ 
Sbjct: 62   TSMASLMVSPSRASLTRMQSSSLLTR--TPSMASLKRMPPR--------------ASRTR 105

Query: 1029 SQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEA 1088
            + PR SL +  RP   S  RS S +   T  SR  L             S         A
Sbjct: 106  TLPRASLMR--RPSTASLTRSPSRASLTTTPSRASLSMTPSTAAALTMPS--------RA 155

Query: 1089 QDVRAPAHAARAKE-AAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSR 1147
               R P  A+     + ASL +     SPTG  +    R+      S A  ++     S 
Sbjct: 156  SLTRTPPRASLTMTPSTASLTRTPPRASPTGMPS----RTSPTGMPSTASLTKMDSTASI 211

Query: 1148 ARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSS 1207
             R  SRA+P    PP   P  S  + S+S                    ++ + + P  +
Sbjct: 212  TRTLSRASP-TGTPPRASPTGSPPRASLSMMPS----------------TALLIRTPPRA 254

Query: 1208 TPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAA 1267
            +P G      SL K +   +I   P         RP    P  +P            S A
Sbjct: 255  SPTGMLSRT-SLTKMDSTASITRTP--------SRPSTASPTGTP------------SRA 293

Query: 1268 TVSPVAGTHPWPQYTTRAPP-GHFSTTPMLSLRQRMMHARF--RNPLSRQPARPSYRQGY 1324
            ++S    T    +   RA P G  S T +  +      +R   R  ++R P+R S     
Sbjct: 294  SLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTPPRASITRTPSRASP---- 349

Query: 1325 NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIK 1384
             G+P         S   P G      P G+     L  GL   A         G P R  
Sbjct: 350  TGKP---------STASPTGTPSRASPTGSPSTASLT-GLSSTASPT------GTPPRAS 393

Query: 1385 LGGDGRTIVDLEGTPVVSPDG-LPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKT 1443
              G   T       P  SP G L      +  +  +  +  P  S  G P         +
Sbjct: 394  PTGTPSTASLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPPRASPTGTPS 453

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRT-TTTRRTTTRRPTTTVRTTTRTTTTTT 1502
               PT T Q T + T  P+T +P  + +T   T + +R + TR P+    T   +T + T
Sbjct: 454  RASPTGT-QSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKMESTASIT 512

Query: 1503 PTPTTPIPTCPPGT 1516
             TP+   PT  P T
Sbjct: 513  RTPSRASPTWTPST 526



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 104/439 (23%), Positives = 158/439 (35%), Gaps = 61/439 (13%)

Query: 1134 SPARPSRPGGPQSRARV--PSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGG 1191
            +P+R S  G P + + +  PSRA+   + P +    S K   S+++       A   +  
Sbjct: 25   TPSRASLTGTPSTASLMGTPSRASLTGTPPRA----SLKGTTSMASLMVSPSRASLTRMQ 80

Query: 1192 KEDLLS-----SSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLA-----PVK 1241
               LL+     +S+ + P    PR  +      A   R P+ A   R  S A     P +
Sbjct: 81   SSSLLTRTPSMASLKRMP----PRASRTRTLPRASLMRRPSTASLTRSPSRASLTTTPSR 136

Query: 1242 RPLPPPPGSSPRASHVPSRL-----PPRSAATVSPVAG--THPWPQYTTRAPPGHFSTTP 1294
              L   P S+  A  +PSR      PPR++ T++P     T   P+ +    P   S T 
Sbjct: 137  ASLSMTP-STAAALTMPSRASLTRTPPRASLTMTPSTASLTRTPPRASPTGMPSRTSPTG 195

Query: 1295 M---LSLRQRMMHARFRNPLSR----------QPARPSYRQGYNGRPNVEGKVLPGSNGK 1341
            M    SL +    A     LSR           P     R   +  P+    +       
Sbjct: 196  MPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRAS 255

Query: 1342 PNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVV 1401
            P G  +++    TK  +D    +             G P R  L     T   +   P  
Sbjct: 256  PTG--MLSRTSLTK--MDSTASITRTPSRPSTASPTGTPSRASLSMTPSTASLMRMLPRA 311

Query: 1402 SPDG-LPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQ-------P 1453
            SP G L      +  +  + ++  P  S+   P       K +T  PT T         P
Sbjct: 312  SPTGMLSRTSLTKMDSTASISRTPPRASITRTPSRASPTGKPSTASPTGTPSRASPTGSP 371

Query: 1454 TT------TTTPLPTTTTPRPT-TATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPT 1506
            +T      ++T  PT T PR + T T    + TR+     PT  +  T+ T   +T +PT
Sbjct: 372  STASLTGLSSTASPTGTPPRASPTGTPSTASLTRKPPRASPTGMLSRTSITKMDSTASPT 431

Query: 1507 -TPIPTCPPGTLERHDDDG 1524
             TP    P GT  R    G
Sbjct: 432  RTPPRASPTGTPPRASPTG 450


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
            sapiens]
          Length = 699

 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 122/600 (20%), Positives = 221/600 (36%), Gaps = 69/600 (11%)

Query: 703  SGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGK------DGEDAPATNSN 756
            +GA ++D++AS+     S     S+++   +   + P++K  K      D ED+      
Sbjct: 38   TGATQQDANASSLLDIYSF-WLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEE 96

Query: 757  APSRSTMSSSVSSHLSSRTQVSEGAEASDG----ESHGDGDREDGGRQAEATAQTLRARP 812
                    ++V +           A+AS+     ES  D D ED  +Q        +A+ 
Sbjct: 97   VQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKA 156

Query: 813  ASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTV----PSRAHPRVPSH---S 865
            A       +     ++  S       + P++ P +    T     P+RA P++ +    S
Sbjct: 157  AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAAS 216

Query: 866  DSHPKLSSGIHGDEEDEK------------------PLPATVVNDHVPSSSRQPISRGWE 907
             S    SS    D E+EK                  P+ A        SSS    S   E
Sbjct: 217  SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE 276

Query: 908  DLRRSPQRGASLHRKEPIPENP---KSTGADTHPQGKYSSLASKAQDVQQSTD-ADTEGH 963
            + ++  +     +   P P  P   KS G  T P  K        +  + S+D +D+   
Sbjct: 277  EQKKPMKNKPGPYSSVPPPSAPPPKKSLG--TQPPKKAVEKQQPVESSEDSSDESDSSSE 334

Query: 964  SPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRD 1023
              K  P       +  +PP A+     S     +      + P  P  T+++        
Sbjct: 335  EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKN-------- 386

Query: 1024 AGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDS 1083
               S ++P ++ T++   +P +     +   P     + +   A  +  E+   S +++ 
Sbjct: 387  ---SSNKPAVT-TKSPAVKPAA-----APKQPVGGGQKLLTRKADSSSSEEESSSSEEEK 437

Query: 1084 TEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGG 1143
            T+      +  A A    +AA SLP  Q  +    + +  D  S        ++ +    
Sbjct: 438  TKKMVATTKPKATA----KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKK 493

Query: 1144 PQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKW 1203
            PQ   +V   AAP  S+P S +   ++S  S S++D  EE+    KG       +     
Sbjct: 494  PQ---KVAGGAAP--SKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANG 548

Query: 1204 PSSSTPRGGKDADGS-LAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLP 1262
             S+ T + GK A  S   +EE++ A  +  + GSL   K+        +P+A  +  + P
Sbjct: 549  TSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTP 608



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 94/477 (19%), Positives = 174/477 (36%), Gaps = 43/477 (9%)

Query: 445 PHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQG----- 499
           P  KA   A  ++S  +   + ++  + ++P      P+A A+   P    S        
Sbjct: 115 PPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSS 174

Query: 500 ------RNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGS----R 549
                 +N K  +  +  K  A   AP KP   A K       S+  +      S     
Sbjct: 175 SEDEPPKNQKPKITPVTVK--AQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEE 232

Query: 550 EDSPMSPSDTQDQKRTL-RPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQP 608
           E +  +P  T  +K+ + + P +   +   P R +  +   +    E   KP   +  +P
Sbjct: 233 EKAAATPKKTVPKKQVVAKAPVK---AATTPTRKSSSSEDSSSDEEEEQKKP---MKNKP 286

Query: 609 RP--GAPPSASASPAHHASTQ----GTSHRPSLPASLNDNDLVDS--DEDERAVGSLHPK 660
            P    PP ++  P     TQ        +  + +S + +D  DS  +E+++        
Sbjct: 287 GPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVS 346

Query: 661 GAFAQPRPALSPSRQSPSSVLRDRSSVHPG-AKPASPARRTPHSGAAEEDSSASAPPSRL 719
            A  +P PA   +  S  S   D S      +KPA   + + +  A    S A  P +  
Sbjct: 347 KATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAP 406

Query: 720 SPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSE 779
             P GG  +LL T+   SS   +     E+       A ++   ++  +  L ++ Q  +
Sbjct: 407 KQPVGGGQKLL-TRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAK-QAPQ 464

Query: 780 GAEASDGESHGDGDREDGGRQAEATAQTLRARPASG-----HFHLLRHKPFAANGRSPSR 834
           G+  S  +S      E+  + +++  +    + A G          + K  ++N  S   
Sbjct: 465 GSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDD 524

Query: 835 FSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVN 891
            S     +L+   SP+   P        +  +     +S    +EE+EK   A VV+
Sbjct: 525 SSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNS---EEEEEEKKKAAVVVS 578



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 117/627 (18%), Positives = 211/627 (33%), Gaps = 68/627 (10%)

Query: 611  GAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPAL 670
            G P   +A PA                S +  +  D D++E        KG   Q + A 
Sbjct: 99   GPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAK 158

Query: 671  SPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLL 730
            +P +++ SS     SS           + TP +  A+  + A   P+R +P         
Sbjct: 159  APPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQ--TKAPPKPARAAPKIANGKAAS 216

Query: 731  PTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHG 790
             +    SS  S   ++ + A       P +  ++ +     ++ T+ S  +E S  +   
Sbjct: 217  SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE 276

Query: 791  DGDREDGGR----------QAEATAQTLRARPASGHFHLLRHKPFA----ANGRSPSRFS 836
            +  +    +           A    ++L  +P        + +P      ++  S S   
Sbjct: 277  EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVE--KQQPVESSEDSSDESDSSSE 334

Query: 837  IGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVP- 895
              + P  +   S  +T P  A     S SDS    SS    DE   KP   T  + + P 
Sbjct: 335  EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS--EDDEAPSKPAGTTKNSSNKPA 392

Query: 896  -----------SSSRQPISRGWEDLRRSPQRGASLHRKEPI-PENPKSTGADTHP----Q 939
                       ++ +QP+  G + L R     +S         E  K   A T P    +
Sbjct: 393  VTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAK 452

Query: 940  GKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPG 999
               S  A +A    + + +D++  S + +   T + A   +P        PS P     G
Sbjct: 453  AALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG 512

Query: 1000 RAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTAS 1059
            +A                   S  +  S  +    L   G PRP  Q    + +   TA 
Sbjct: 513  KAESS---------------NSSSSDDSSEEEEEKLKGKGSPRP--QAPKANGTSALTAQ 555

Query: 1060 SRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGA 1119
            +      A +N +E+ +          ++  ++       AKEA     K  ++++P   
Sbjct: 556  N----GKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTP--- 608

Query: 1120 GAGGDHRSQRGHAASPARPSRPGGPQSRARV------PSRAAPGKSEPPSKRPLSSKSQQ 1173
                  +     A+SP R  R    +  +RV        R A G     + + L     +
Sbjct: 609  NTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGK 668

Query: 1174 SVSAEDDEEEDAGFFKGGKEDLLSSSV 1200
            S   E  +++  G ++GG   +  +S+
Sbjct: 669  SFRHEKTKKK-RGSYRGGSISVQVNSI 694


>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
          Length = 3664

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 187/907 (20%), Positives = 304/907 (33%), Gaps = 129/907 (14%)

Query: 353  RTPESAPTTAPENLNVWPVNGKPTVVAASWDALPE-----TEGKVKEYIL-----SYAPA 402
            +TPESAP      L   P  G P+V   + ++ P      T  K  E  L     +  PA
Sbjct: 1618 KTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPA 1677

Query: 403  LKPFGAKSLTYPGDTTSALVD--GLQPG---ERYLFKIRATNRRGLGPHSKAFIVAMPTT 457
                 AK  + P       ++   L PG   ++    + A    G       ++ A P T
Sbjct: 1678 TVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPT 1737

Query: 458  SKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANG 517
              A   Q  E N  PE P+ + P  +    S+  + P + +     D   D      AN 
Sbjct: 1738 PGASFSQ-AESNVDPE-PDSTQPLSKPAQKSEEANEPKAEKPDATADAEPD------ANQ 1789

Query: 518  GAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVV 577
             A   P+ +   +E+L++               D P++  D +  K      S+   + V
Sbjct: 1790 KAEAAPESQPPASEDLEV---------------DPPVAAKDKKPNK------SKRSKTPV 1828

Query: 578  APGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPA 637
                 ++    P   + E +D+     +  PR  A             T+  S   +   
Sbjct: 1829 QAAAVSI-VEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADL 1887

Query: 638  SLNDNDLVDSDEDERAVGSLH-PKGAFAQPRPALSPSRQSPSSVLR-DRSSVHPGAKPAS 695
               +  L  S    R V S++   G      P   P  Q   +  R +R      A P +
Sbjct: 1888 EHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTT 1947

Query: 696  PAR----RTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAP 751
            P R    +T      EE++ A  P   L PP G  S   P     ++     GK G++ P
Sbjct: 1948 PRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRS---PRSQKTAAGGGPQGKKGKNEP 2004

Query: 752  ATNSNAPSRST-MSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRA 810
              ++  P  +T +   +    SS    +   EA   +     DR+D G        T + 
Sbjct: 2005 KVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKR---DRKDAG--------TDKN 2053

Query: 811  RPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQ-PSSSPQSTVPSRAHPR--------- 860
             P +    ++  KP A    S S+    R  RL    S+    V +   PR         
Sbjct: 2054 PPETAPVEVVEKKP-APEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGER 2112

Query: 861  -------VPSHSDSHPK---LSSGIHGDEED-EKPLPATVVNDHVPS------SSRQPIS 903
                    P  S+S  K   LSS +  D  D +K      V+   PS      + +  + 
Sbjct: 2113 ESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELE 2172

Query: 904  RGWEDLRRSPQRGASLHRKEPIPEN--PKSTGADTHPQGKYSSLASKAQDVQQSTDADTE 961
            +  E + +  +  AS   K   PE   P+      H Q   + LA+    +      + E
Sbjct: 2173 QAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAH-QASETELAAAIGSIINDISGEPE 2231

Query: 962  GH-SPKAQPGSTDRHASP-----ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQH 1015
               +P   PG +     P     A  P+    +       +    A  +   PPV     
Sbjct: 2232 NFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDP 2291

Query: 1016 HPGP-QSRDAGRSPSQPRLSLTQA---------------GRPRPTSQGRSHSSSDPYTAS 1059
              GP  +++A  + S+   S+ +A               GR + T   R  +++    A 
Sbjct: 2292 SAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAP 2351

Query: 1060 SRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPA---HAARAKEAAASLPKHQQVESP 1116
                +P + Q Q E    +        EA      +   H+   +   + L K    E+ 
Sbjct: 2352 VESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTEN- 2410

Query: 1117 TGAGAGGDHRSQRGHAASPARPSRP------GGPQSRARVPSRAAPGKSEPPSKRPLSSK 1170
            +      + R+    +  P  P  P        PQ+R RV S        PPS   +   
Sbjct: 2411 SSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIP 2470

Query: 1171 SQQSVSA 1177
            +  SV+A
Sbjct: 2471 TLPSVTA 2477



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 137/681 (20%), Positives = 238/681 (34%), Gaps = 76/681 (11%)

Query: 528  KKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAV--R 585
            +K +E D +  E+  +E+  +   +P S  + +D +    P      SV  P  T V   
Sbjct: 1595 QKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPP------SVGPPSVTVVTLE 1648

Query: 586  ARMPALPRREGVDKPGFSLATQPRPGAPPSAS--ASPAHHASTQGTSHRPSL---PASLN 640
            +   AL +  G       L T+ +   P + S  A PA   +         +   P +  
Sbjct: 1649 SAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADP 1708

Query: 641  DND--LVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPAR 698
            D +  ++ +  +E + G   P      P P  S S Q+ S+V  +  S  P +KPA  + 
Sbjct: 1709 DKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFS-QAESNVDPEPDSTQPLSKPAQKSE 1767

Query: 699  RTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAP 758
                  A + D++A A P              P    L        KD +   +  S  P
Sbjct: 1768 EANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTP 1827

Query: 759  SRSTMSSSVSSHLSSRTQVSEGAEASDGES-HGDGDR-EDGGRQAEATAQTLRARPASGH 816
             ++   S V   ++ +++  +  +     S  G+  +  +   +AE   +T     A+  
Sbjct: 1828 VQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADL 1887

Query: 817  FHLLRHKPFAANGRSPSRFSI-------GRGPRLQPSSSPQST--------VPSRAHPRV 861
             H     P +   R   R           R P  +P   P+ T          + A P  
Sbjct: 1888 EHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTT 1947

Query: 862  PSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHR 921
            P      PK       +EE+E   PA  +    P   R P S+        PQ     + 
Sbjct: 1948 PRRG-RPPKTRRRADEEEENEAKEPAETLKP--PEGWRSPRSQK-TAAGGGPQGKKGKNE 2003

Query: 922  KEPIPENPKSTGADTHPQ--GKYSSLASKAQDVQQST-------DADTEGHSPKAQPGST 972
             +     P++T  +  PQ   K SS+  KA + +  +       DA T+ + P+  P   
Sbjct: 2004 PKVDATRPEAT-TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEV 2062

Query: 973  DRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPR 1032
                 PA    ++S++  S   R+   ++   +      + +   G  ++   R      
Sbjct: 2063 -VEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPR---GAAAQAGERESGVVA 2118

Query: 1033 LSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDV- 1091
            +S  ++  P+      S   SDP             + +D  A G   + +   +  ++ 
Sbjct: 2119 VSPEKSESPQKEDGLSSQLKSDPVDPDKEP------EKEDVSASGPSPEATQLAKQMELE 2172

Query: 1092 RAPAHAARAKEAAASL-----------------PKHQQVESPTGAGAGGDHRSQRGHAAS 1134
            +A  H A+  EA+AS                  P HQ  E+   A  G       G   +
Sbjct: 2173 QAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPEN 2232

Query: 1135 -PARPSRPGGPQSRARVPSRA 1154
             PA P  PG  Q+  + P+ A
Sbjct: 2233 FPAPPPYPGESQTDLQPPAGA 2253



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 71/299 (23%), Positives = 107/299 (35%), Gaps = 53/299 (17%)

Query: 445  PHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPR-APASSQHPSVPASPQGRNAK 503
            P +   +V +P  SKA  +   E    P+     +P+P   P     P+   +P G  A+
Sbjct: 3210 PRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHG-EAR 3268

Query: 504  DLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQK 563
             L +   N++    G P  P +      ++   S E+  E   G                
Sbjct: 3269 ILTVTPSNQL---QGLPLTPPVVVTHGVQIVHSSGELFQEYRYG--------------DI 3311

Query: 564  RTLRPPSRHGH-------SVVAPGRTAVRARMPALPRREGVDKPGFSLATQP-------- 608
            RT  PP++  H       SV  P RT   A+ P  P  E +  P    +TQP        
Sbjct: 3312 RTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPP-PEGEPLQPPQPVQSTQPAQPAPPCP 3370

Query: 609  -----RPGAPPSASASPAHHASTQGTS---HRPSLPASLNDNDLVDSDEDERAVGSLHPK 660
                 +PG PPS S  P      +GT     +P LPA   +       + +RA     P 
Sbjct: 3371 PSQLGQPGQPPS-SKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPT 3429

Query: 661  GAFAQP--------RPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSS 711
             +F  P         P   P++ +P   L   ++  P   P      T    A ++DSS
Sbjct: 3430 -SFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSS 3487



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 119/580 (20%), Positives = 183/580 (31%), Gaps = 110/580 (18%)

Query: 475  PEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELD 534
            P PS P P +   + HPS  AS          L     ++   G P    + +   E+  
Sbjct: 3026 PRPSGPGPSSFPRASHPSSTASTA--------LSTNATVMLAAGIPVPQFISSIHPEQSV 3077

Query: 535  L-------QSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRAR 587
            +       Q+  ++   +   R ++P  PS T     ++RP + H              R
Sbjct: 3078 IMPPHSITQTVSLSHLSQGEVRMNTPTLPSITY----SIRPEALHS------------PR 3121

Query: 588  MPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDS 647
             P  P++  V  P  +   QP P   P+ ++   H    +   H P   A+      V  
Sbjct: 3122 APLQPQQIEVRAPQRASTPQPAPAGVPALASQ--HPPEEEVHYHLPVARATAPVQSEVLV 3179

Query: 648  DEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAE 707
             + E     LHP       R  + P   + S   R    V     PAS A + P   AA+
Sbjct: 3180 MQSEYR---LHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVK-VPPASKAPQQPGKEAAK 3235

Query: 708  EDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSV 767
               + +AP    +P        +P    L +P          APA +  A   +   S+ 
Sbjct: 3236 TPDAKAAPTPTPAP--------VPVPVPLPAP----------APAPHGEARILTVTPSNQ 3277

Query: 768  SSHL--SSRTQVSEGAEA--SDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHK 823
               L  +    V+ G +   S GE   +    D          T    PA+    L    
Sbjct: 3278 LQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRT 3337

Query: 824  PFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEK 883
              AA G  P       G  LQP    QST P++  P  P      P              
Sbjct: 3338 KTAAQGPPPE------GEPLQPPQPVQSTQPAQPAPPCPPSQLGQP-------------- 3377

Query: 884  PLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYS 943
                       PSS    +S+      +  Q G    R   +P  P +   + H Q    
Sbjct: 3378 --------GQPPSSKMPQVSQE----AKGTQTGVEQPR---LPAGPANRPPEPHTQ---- 3418

Query: 944  SLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQ 1003
                      Q   A+T    P + P        P  P +  +Q  P  P  +     P 
Sbjct: 3419 ---------VQRAQAET---GPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPS 3466

Query: 1004 QQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRP 1043
              P   +  ++  P P+   +    SQ  + + Q  +  P
Sbjct: 3467 TPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYP 3506



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 41/169 (24%), Positives = 67/169 (39%), Gaps = 36/169 (21%)

Query: 825 FAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKP 884
           +A+  RSP+RF     PR +P +  Q T+PS  H                I+ D+   + 
Sbjct: 184 YASRSRSPNRFD-AHDPRYEPRAREQFTLPSVVH--------------RDIYRDDITREV 228

Query: 885 LPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSS 944
                  ++  S SR P S   +   +SPQR AS   +     +P  +G+ +        
Sbjct: 229 RGRRPERNYQHSRSRSPHSS--QSRNQSPQRLASQASRPT--RSPSGSGSRS-------- 276

Query: 945 LASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVP 993
                    +S+ +D+   S      S+D  +S +    ARS Q  +VP
Sbjct: 277 ---------RSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVP 316



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 40/158 (25%), Positives = 68/158 (43%), Gaps = 21/158 (13%)

Query: 961  EGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQ 1020
            + H P+ +P + ++   P+     R      + R +  GR P++      + S H    Q
Sbjct: 195  DAHDPRYEPRAREQFTLPS--VVHRDIYRDDITREVR-GRRPERNYQHSRSRSPH--SSQ 249

Query: 1021 SRDAGRSPSQPRLSLTQAGRPRPTSQG---RSHSSSDPYTASSRGMLPTALQNQDEDAQG 1077
            SR+       P+   +QA RP  +  G   RS SSS    +SS     ++  +   D+  
Sbjct: 250  SRN-----QSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSS-----SSTSSDSSDSSS 299

Query: 1078 SYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVES 1115
            S  DDS    A+ V++ A  A   +  +SL K +  +S
Sbjct: 300  SSSDDS---PARSVQSAAVPAPTSQLLSSLEKDEPRKS 334



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 39/168 (23%), Positives = 62/168 (36%), Gaps = 28/168 (16%)

Query: 972  TDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQP 1031
            +DR     R P  RSQ    + R  +PG +P Q    P                 S S+ 
Sbjct: 711  SDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLP-----------------SDSER 753

Query: 1032 RLSLTQAGRPRPTSQGRSHSSSDP-YTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQD 1090
            RL    + R      G   S S P Y    +  L    +N+  D + ++D +  E E + 
Sbjct: 754  RLYSRSSDR-----SGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRL 808

Query: 1091 VRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARP 1138
            +R        K+      +  +V SP+   +  D  ++R    SP +P
Sbjct: 809  IR---KEKVEKDKTDKQKRKGKVHSPSSQSSETDQENER--EQSPEKP 851



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 44/175 (25%), Positives = 71/175 (40%), Gaps = 20/175 (11%)

Query: 1065 PTALQNQ--DEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAG-- 1120
            P+AL+    D+  +     +   VE   V   A  A ++ A A + + +QV+ P GA   
Sbjct: 1651 PSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPA-SEPAPAPVEQLEQVDLPPGADPD 1709

Query: 1121 -------AGGDHRSQRGHAAS-PARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQ 1172
                   AG +  S         A+P  PG   S+A   S   P   EP S +PLS  +Q
Sbjct: 1710 KEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAE--SNVDP---EPDSTQPLSKPAQ 1764

Query: 1173 QSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRG-GKDADGSLAKEEREP 1226
            +S  A + + E        + D  +      P S  P     + D  +A ++++P
Sbjct: 1765 KSEEANEPKAEKPDATADAEPD-ANQKAEAAPESQPPASEDLEVDPPVAAKDKKP 1818


>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
          Length = 2303

 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 189/861 (21%), Positives = 299/861 (34%), Gaps = 156/861 (18%)

Query: 537  STEITGEEELGSREDSPMSPSDTQDQKRTLRPPSR-----HGHSVVAPGRTAVRARMPAL 591
            +  ++ E   G   D P  P+  Q  + T RP S      H H     GR+A ++R  A 
Sbjct: 1403 AASLSDETLQGPPRDQPGGPAGRQ--RPTGRPTSARQAMGHRHKAGGAGRSAEQSR-GAG 1459

Query: 592  PRREGVDKPGFSLATQPRPGAPPSASASP--AHHASTQGTSHRPSLPASLNDNDLV---- 645
              R G++ P          G PPSA A    +    T+G     SL  +    + V    
Sbjct: 1460 KNRAGLELP---------LGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFY 1510

Query: 646  --DSDEDERAVG--------SLHPKGAFAQPRP-----ALSPSRQSPSSVLRDRSSVHPG 690
              DSDE+  A          S  P+ AF + RP     A +PS+ +P++    R+     
Sbjct: 1511 GNDSDEEPPAAAPTPTHRRTSAIPR-AFTRERPQGRKEAPAPSKAAPAAPPPART----- 1564

Query: 691  AKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDA 750
             +P+  A  TP   +    +S+ + P    PP        P       P   GG+D   +
Sbjct: 1565 -QPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVT--KDPGPGGGRDSSPS 1621

Query: 751  PAT---------NSNAPSRSTMSSSVSSHLSSRTQVSE---------GAEASDGESHGDG 792
            P           +S  P R    S +       T++ E         G EA+  +   D 
Sbjct: 1622 PRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDL 1681

Query: 793  DR------EDGGRQA-----EATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGR-- 839
            D       ++G         +A A T  A   S             +   P +   GR  
Sbjct: 1682 DSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQA 1741

Query: 840  ----GPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPA-----TVV 890
                G   +P     ++V +   PR P+  +          G ++    +PA     TV+
Sbjct: 1742 EGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP-------RGTQKTTPGVPAVLRGRTVI 1794

Query: 891  NDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEP-----IPENPKSTGADTHPQGKYSSL 945
              +VPS + +   +G    R +P++ A     +P     +P   +      H   K S L
Sbjct: 1795 --YVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSEL 1852

Query: 946  ASKAQDVQQST---------DADTEGHSPKAQP------------------GSTDRHASP 978
            A+ +Q  + +T          + +   SP +QP                  G++    +P
Sbjct: 1853 ATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTP 1912

Query: 979  ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSR---DAGRSPSQPRLSL 1035
            AR   A+  +    P R+   + P ++ PPP+A +   PGP+ R   +AG      RL L
Sbjct: 1913 ARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGL 1972

Query: 1036 TQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPA 1095
             +       +   S  S     +  R  L    ++     + S    +    +    A  
Sbjct: 1973 VR------VASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASP 2026

Query: 1096 HAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPA---RPSRPGGPQSRARVPS 1152
               R    A  L   +  E       G     QR  AA P+   RP+R    +S +R+P 
Sbjct: 2027 RRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPV 2086

Query: 1153 RAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPK-WPSSSTP-- 1209
            RA   +  P + +  +S    SV+   D    A           S   P+  P  + P  
Sbjct: 2087 RAPAAR--PETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGT 2144

Query: 1210 --RGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAA 1267
              R  +D D         PA AL  RG +  P   P  PPP  +       S    ++  
Sbjct: 2145 TWRRIRDEDVPHILRSTLPATALPLRGST--PEDAPAGPPPRKT-------SDAVVQTEE 2195

Query: 1268 TVSPVAGTHPWPQYTTRAPPG 1288
              +P   +   P   TR PPG
Sbjct: 2196 VAAPKTNSSTSPSLETREPPG 2216



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 193/899 (21%), Positives = 301/899 (33%), Gaps = 238/899 (26%)

Query: 451  IVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRA--PASSQHPSV----PASPQGRNAKD 504
            ++A  T     +  +     +PE  EP +  PR   PA ++ P       +SP  R A++
Sbjct: 1568 LIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEE 1627

Query: 505  LLLDLKNKILANGGAP----RKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQ 560
            LL    +  L     P    R+ + RA + +E   + +   GEE  GS   S +   +  
Sbjct: 1628 LLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEW- 1686

Query: 561  DQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDK--PGFSLATQPRPGAPPSASA 618
                  R      +S+V     A  A   A    + +     G S+ +  +P        
Sbjct: 1687 ------RAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQP-------- 1732

Query: 619  SPAHHASTQ-----GTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSP- 672
             P H    Q     G++ RP                ++R   S+   G+   P     P 
Sbjct: 1733 -PKHRKGRQAEGEMGSARRP----------------EKRGAASVKTSGSPRSPAGPEKPR 1775

Query: 673  --SRQSPS--SVLRDRSSVH-----PGAKP-ASPARRTPHSGAAEEDSSASAPPSRLSPP 722
               + +P   +VLR R+ ++     P A+P  +P  R      A    +  A P+++  P
Sbjct: 1776 GTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSP 1835

Query: 723  HGGSSRLLPTQPHLSSPLSKGGKDGEDA--PATNSNAPSRSTMSSSVSSHLSSRTQ--VS 778
                SR L  +P  +S L+   +    A  PA  +  PS S+  +S +S    R +  V+
Sbjct: 1836 GQQRSRSLH-RPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVT 1894

Query: 779  EGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIG 838
            + A A  G               +  A+TL A+         +HK      RSP R    
Sbjct: 1895 QAAGALPGPG--------ASPVPKTPARTLLAK---------QHK----TQRSPVRIPFM 1933

Query: 839  RGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSS 898
            + P  +        VP    PR  + +++ P    G  G         A+ ++    SS 
Sbjct: 1934 QRPARRGPPPLARAVPEPG-PRGRAGTEAGPGARGGRLGLVR-----VASALSSGSESSD 1987

Query: 899  RQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDA 958
            R    R    ++ SP     L R+                    S L+S          A
Sbjct: 1988 RSGFRRQLTFIKESP----GLRRRR-------------------SELSS----------A 2014

Query: 959  DTEGHSPKAQPGSTDRHASPARPP----AARSQQHPSVPRRMTPGRAPQQQPPPPVATSQ 1014
            ++   +P+   G++ R   PA P     ++R ++  + PR+   G AP +Q PP      
Sbjct: 2015 ESAASAPQ---GASPRRGRPALPAVFLCSSRCEELRAAPRQ---GPAPARQRPPAA---- 2064

Query: 1015 HHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDED 1074
              P P  R A R+                             T+ S   LP         
Sbjct: 2065 -RPSPGERPARRT-----------------------------TSESPSRLP--------- 2085

Query: 1075 AQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGA------GAGGDHRSQ 1128
                            VRAPA      +  ASLP       P GA       A    RS 
Sbjct: 2086 ----------------VRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSS 2129

Query: 1129 RGHAASPARPSRPGGPQSRAR-----------VPSRAAPGKSEPPSKRPLSSKSQQSVSA 1177
             G      R + PG    R R           +P+ A P +   P   P     +++  A
Sbjct: 2130 DGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDA 2189

Query: 1178 EDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSL 1237
                EE A               PK  SS++P          + E REP  A  P GG L
Sbjct: 2190 VVQTEEVAA--------------PKTNSSTSP----------SLETREPPGA--PAGGQL 2223

Query: 1238 APVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPML 1296
            + +   +  P  +    S  P        A     A  H  P  + R PP ++  +PM+
Sbjct: 2224 SLLGSDVDGPSLAKAPIS-APFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMV 2281



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 132/608 (21%), Positives = 198/608 (32%), Gaps = 94/608 (15%)

Query: 924  PIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPA 983
            P  E+   T +       +SS AS + +  Q    D  G       G   R     RP +
Sbjct: 1382 PAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPG-------GPAGRQRPTGRPTS 1434

Query: 984  ARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRP 1043
            AR     ++  R   G A +                QSR AG++ +   L L   GRP P
Sbjct: 1435 ARQ----AMGHRHKAGGAGRS-------------AEQSRGAGKNRAGLELPL---GRP-P 1473

Query: 1044 TSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGS-YDDDSTEVEAQDVRAPAHAARAKE 1102
            ++      S    T     +    L    E+A    Y +DS E        P H      
Sbjct: 1474 SAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTH-----R 1528

Query: 1103 AAASLPKHQQVESPTGAGAGGDHRSQRGHAASPAR--PS-----RPGGPQSRARVPSRAA 1155
              +++P+    E P G             A  PAR  PS      P      +   S + 
Sbjct: 1529 RTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSE 1588

Query: 1156 PGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDA 1215
            P  SEPP+  P   +   +         D+       E+LL   +    SS+ PR     
Sbjct: 1589 PEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCI----SSALPRRRPPV 1644

Query: 1216 DGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPS---RLPPRSAATVSPV 1272
             G   ++ R   +   P  GS     R        S RAS + S   R     A ++  V
Sbjct: 1645 SGLRRRKPRATRLDERPAEGS-----RERGEEAAGSDRASDLDSVEWRAIQEGANSI--V 1697

Query: 1273 AGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEG 1332
               H     T  A     S    +S     + +  + P  R+  +     G   RP   G
Sbjct: 1698 TWLHQAAAATREASSESDSILSFVS--GLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRG 1755

Query: 1333 KVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTI 1392
                 ++G P        P+GT+                  + + G P  ++    GRT+
Sbjct: 1756 AASVKTSGSPRSPAGPEKPRGTQ------------------KTTPGVPAVLR----GRTV 1793

Query: 1393 VDLEG-TPVVSPDGLPLFGQGRHGTP-------LAN-AQDKPILSLGGKPLVGLEVIKKT 1443
            + +    P   P G P    G   TP       LA  A    + S G +    L    KT
Sbjct: 1794 IYVPSPAPRAQPKGTP----GPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKT 1849

Query: 1444 THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTP 1503
            +   T +  P + T P     TP  +++ T  +  ++    +RP  T           +P
Sbjct: 1850 SELATLSQPPRSATPPARLAKTPSSSSSQT--SPASQPLPRKRPPVTQAAGALPGPGASP 1907

Query: 1504 TPTTPIPT 1511
             P TP  T
Sbjct: 1908 VPKTPART 1915


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,639,300
Number of Sequences: 37866
Number of extensions: 5680446
Number of successful extensions: 65632
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 348
Number of HSP's successfully gapped in prelim test: 1958
Number of HSP's that attempted gapping in prelim test: 27413
Number of HSP's gapped (non-prelim): 20827
length of query: 1894
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1777
effective length of database: 13,817,196
effective search space: 24553157292
effective search space used: 24553157292
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.