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Search of human proteins with 93204861
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|93204861 protein phosphatase 1, regulatory (inhibitor)
subunit 9A [Homo sapiens]
(1098 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|93204861 protein phosphatase 1, regulatory (inhibitor) subuni... 2160 0.0
gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo ... 652 0.0
gi|28557802 sterile alpha motif domain containing 14 [Homo sapiens] 134 6e-31
gi|148746189 multiple PDZ domain protein [Homo sapiens] 79 3e-14
gi|87196343 PDZ domain containing 2 [Homo sapiens] 72 4e-12
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 70 8e-12
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 70 8e-12
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 70 8e-12
gi|112382257 InaD-like [Homo sapiens] 70 1e-11
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 68 5e-11
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 68 5e-11
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 68 5e-11
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 64 8e-10
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 64 1e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 62 3e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 62 3e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 62 3e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 62 3e-09
gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens] 61 7e-09
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 60 1e-08
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 60 1e-08
gi|56550043 sarcolemma associated protein [Homo sapiens] 60 1e-08
gi|71061468 centromere protein E [Homo sapiens] 60 1e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 60 1e-08
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 60 1e-08
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 60 1e-08
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 60 1e-08
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 60 1e-08
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 59 2e-08
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 58 4e-08
>gi|93204861 protein phosphatase 1, regulatory (inhibitor) subunit 9A
[Homo sapiens]
Length = 1098
Score = 2160 bits (5598), Expect = 0.0
Identities = 1098/1098 (100%), Positives = 1098/1098 (100%)
Query: 1 MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYG 60
MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYG
Sbjct: 1 MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYG 60
Query: 61 SNVNRIKNLFMQMGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSV 120
SNVNRIKNLFMQMGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSV
Sbjct: 61 SNVNRIKNLFMQMGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSV 120
Query: 121 SERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKS 180
SERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKS
Sbjct: 121 SERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKS 180
Query: 181 NRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPS 240
NRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPS
Sbjct: 181 NRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPS 240
Query: 241 VTVTNLDTFGHLKDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQS 300
VTVTNLDTFGHLKDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQS
Sbjct: 241 VTVTNLDTFGHLKDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQS 300
Query: 301 KEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQ 360
KEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQ
Sbjct: 301 KEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQ 360
Query: 361 RKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTE 420
RKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTE
Sbjct: 361 RKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTE 420
Query: 421 QDEEEDSDENSYYQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRND 480
QDEEEDSDENSYYQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRND
Sbjct: 421 QDEEEDSDENSYYQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRND 480
Query: 481 EVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVT 540
EVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVT
Sbjct: 481 EVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVT 540
Query: 541 EGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVA 600
EGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVA
Sbjct: 541 EGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVA 600
Query: 601 QLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELP 660
QLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELP
Sbjct: 601 QLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELP 660
Query: 661 ENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQ 720
ENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQ
Sbjct: 661 ENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQ 720
Query: 721 NIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELD 780
NIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELD
Sbjct: 721 NIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELD 780
Query: 781 FIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTS 840
FIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTS
Sbjct: 781 FIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTS 840
Query: 841 LGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSR 900
LGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSR
Sbjct: 841 LGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSR 900
Query: 901 TRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDES 960
TRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDES
Sbjct: 901 TRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDES 960
Query: 961 LDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLL 1020
LDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLL
Sbjct: 961 LDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLL 1020
Query: 1021 QLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRK 1080
QLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRK
Sbjct: 1021 QLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRK 1080
Query: 1081 SKKTEKMTSTTAEGAGEQ 1098
SKKTEKMTSTTAEGAGEQ
Sbjct: 1081 SKKTEKMTSTTAEGAGEQ 1098
>gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo
sapiens]
Length = 817
Score = 652 bits (1682), Expect = 0.0
Identities = 403/868 (46%), Positives = 521/868 (60%), Gaps = 93/868 (10%)
Query: 1 MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYG 60
M+KTE G LRSASPHR+AY QALK P + G + +G + +KYG
Sbjct: 1 MMKTEPRGPGGPLRSASPHRSAYEAGIQALKP----PDAPGPDEAPKG-----AHHKKYG 51
Query: 61 SNVNRIKNLFMQMGMEPNENA--------AVIAKTRGKGGHSSPQRRMKPKEFLEKTDGS 112
SNV+RIK++F+QMG + A + +G S R E ++ + +
Sbjct: 52 SNVHRIKSMFLQMGTTAGPSGEAGGGAGLAEAPRASERGVRLSLPRASSLNENVDHS--A 109
Query: 113 VVKLESSVSERISRFDTMYDGPSY---------SKFTETRKMFERSVHESGQNNRYSPKK 163
++KL +SVSER+SRFD+ PS S+ ETRK+FERS + + K
Sbjct: 110 LLKLGTSVSERVSRFDSK-PAPSAQPAPPPHPPSRLQETRKLFERSAPAAAGGD-----K 163
Query: 164 EKAGGSEPQDEWGGSKSNR--------GSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSP 215
E A + E G + + GST++LD L + +AVSPTVSQLSAVFE DS
Sbjct: 164 EAAARRLLRQERAGLQDRKLDVVVRFNGSTEALDKLDA--DAVSPTVSQLSAVFEKADSR 221
Query: 216 SAI--------------ISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWPPS 261
+ + ++ K + V P P+ + + + PP
Sbjct: 222 TGLHRGPGLPRAAGVPQVNSKLVSKRSRVFQPPPPPPPAPS-GDAPAEKERCPAGQQPPQ 280
Query: 262 NKRGV---DTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDK 318
++ + PV S + S PGE IQ + N T +
Sbjct: 281 HRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAAS 340
Query: 319 DGPEEPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQRKELAGGDFTSPDASASS 378
PEEP A++ ++ +P + + + A V E + +KE DF+ D S
Sbjct: 341 PAPEEPKAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKE----DFSEADLVDVS 396
Query: 379 CGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSYYQPDME 438
+ EDS G E DE+++ D Y+P+
Sbjct: 397 AYSGLGEDSA--------------------------GSALEEDDEDDEEDGEPPYEPESG 430
Query: 439 YSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVE 498
EI GL EEE+ +RKI FS+API+VF+TYSNEDYDRRN++VDP+AASAEYELEKRVE
Sbjct: 431 CVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVE 490
Query: 499 KLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIV 558
+LELFPVELEKD +GLGISIIGMG GAD GLEKLGIFVKTVTEGGAA RDGRIQVND +V
Sbjct: 491 RLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLV 550
Query: 559 EVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLE 618
EVDG SLVGVTQ+FAA+VLRNTKG VRF+IGRE+PG+ SEVAQLI QTLEQER QRE++E
Sbjct: 551 EVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMME 610
Query: 619 QHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPSELDTSKLSH 678
Q YAQY DD+ETGEYATDE+E E+ P PG +MAIEVFEL ENED SP +++ KL H
Sbjct: 611 QRYAQYGEDDEETGEYATDEDE-ELSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLVH 669
Query: 679 KFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIE 738
KFKELQIKHAVTEAEIQ+LK KLQ+ E EK RW +EK QL+Q++EENKERM KLE YW E
Sbjct: 670 KFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGE 729
Query: 739 AQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKA 798
AQ+LC V+EHL+ETQ+QYQALE+KY+KAK+LIKD+QQKE++F+K++ A+R+ +E+ E A
Sbjct: 730 AQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELA 789
Query: 799 HLVEVQGLQVRIRDLEAEVFRLLKQNGT 826
E+ L +I +LE + L N T
Sbjct: 790 RKEEMDKLLDKISELEGNLQTLRNSNST 817
>gi|28557802 sterile alpha motif domain containing 14 [Homo sapiens]
Length = 445
Score = 134 bits (336), Expect = 6e-31
Identities = 88/204 (43%), Positives = 114/204 (55%), Gaps = 24/204 (11%)
Query: 873 PETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTD-GEDSLERKNFTFNDDFSPSS 931
P+ E K ++AQL + + L ST G +S T +DD +P S
Sbjct: 261 PKHEGFSPKKSASQAQLLAHAQEALSNSWCLVQDFGSTQIGMES------TLSDDSTPPS 314
Query: 932 TSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQ 991
+S SG E K +L+ SSDE LD+ P H W+ Q
Sbjct: 315 SSPKIPSGPWQEAKCSYPYHTLSQSSDE--------FLDEPLPPVH---------HWTSQ 357
Query: 992 QVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMS 1051
QV WL SLNLEQY +EF+A+ + G QLLQLDG+KLK+LG++ S DRA+VK+KLKEM +
Sbjct: 358 QVGQWLQSLNLEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRALVKRKLKEMAAA 417
Query: 1052 LEKARKAQEKMEKQREKLRRKEQE 1075
EK RKAQEK +QREKLRR+EQE
Sbjct: 418 AEKERKAQEKAARQREKLRRREQE 441
Score = 57.8 bits (138), Expect = 6e-08
Identities = 33/50 (66%), Positives = 35/50 (70%), Gaps = 1/50 (2%)
Query: 867 DLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSST-DGEDS 915
DL+ AVPET RLDS K RAQL K RR RPSR+RL DS SS DGE S
Sbjct: 15 DLDLAVPETARLDSSLHKARAQLLAKGRRHRPSRSRLRDSASSAEDGEGS 64
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 78.6 bits (192), Expect = 3e-14
Identities = 47/102 (46%), Positives = 62/102 (60%), Gaps = 2/102 (1%)
Query: 498 EKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQI 557
E+ E F VEL K+ GLGI+I G +G D LE GIFVK++T+ A + DGRIQ+ DQI
Sbjct: 371 EESETFDVELTKNVQGLGITIAGY-IG-DKKLEPSGIFVKSITKSSAVEHDGRIQIGDQI 428
Query: 558 VEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEV 599
+ VDG +L G T A VLR+T V + R Q +E+
Sbjct: 429 IAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAEL 470
Score = 70.5 bits (171), Expect = 8e-12
Identities = 40/84 (47%), Positives = 53/84 (63%), Gaps = 3/84 (3%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
+ LE+ DGLG SI+G G G+ G L I+VKTV GAA DGR++ DQI+ V+G S
Sbjct: 1959 ITLERGPDGLGFSIVG-GYGSPHG--DLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQS 2015
Query: 565 LVGVTQNFAATVLRNTKGNVRFVI 588
L GVT A +L+ TKG V ++
Sbjct: 2016 LEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 62.8 bits (151), Expect = 2e-09
Identities = 42/107 (39%), Positives = 60/107 (56%), Gaps = 6/107 (5%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
+E+ K GLG+SI+G G+D L I + V E GAA +DGR+ DQI+EV+GI
Sbjct: 1630 IEISKGRTGLGLSIVG---GSDTLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGR-EKPGQVSEVAQLISQTLEQE 610
L T + A VLR T VR + R E P + EV ++ L+++
Sbjct: 1685 LRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKK 1731
Score = 58.5 bits (140), Expect = 3e-08
Identities = 46/187 (24%), Positives = 85/187 (45%), Gaps = 20/187 (10%)
Query: 478 RNDEVDPVAASAEYELE----KRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLG 533
+N E +P +++ ++ K V+ LEL KD+ GLGI+I + G
Sbjct: 1458 QNKETEPTVTTSDAAVDLSSFKNVQHLEL-----PKDQGGLGIAISEEDTLS-------G 1505
Query: 534 IFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKP 593
+ +K++TE G A DGR++V DQI+ VD +VG ++L+ K V+ I E P
Sbjct: 1506 VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENP 1565
Query: 594 GQVSEVAQLISQTLEQERRQRELLEQHYAQYDADD----DETGEYATDEEEDEVGPVLPG 649
+ + + + E++ + L+ + + + A + P++PG
Sbjct: 1566 DSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPG 1625
Query: 650 SDMAIEV 656
+ IE+
Sbjct: 1626 CETTIEI 1632
Score = 58.2 bits (139), Expect = 4e-08
Identities = 33/122 (27%), Positives = 62/122 (50%), Gaps = 14/122 (11%)
Query: 501 ELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEV 560
EL +ELEK GLG+S+ G + ++ +F+ + GAA +DGR+Q+ D+++E+
Sbjct: 1347 ELHMIELEKGHSGLGLSLAG-----NKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEI 1401
Query: 561 DGISLVGVTQNFAATVLRNTKGNVRFVIGREK---------PGQVSEVAQLISQTLEQER 611
+G L G + A+++++ V+ + R K PG E S+ L+ +
Sbjct: 1402 NGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKE 1461
Query: 612 RQ 613
+
Sbjct: 1462 TE 1463
Score = 57.8 bits (138), Expect = 6e-08
Identities = 43/144 (29%), Positives = 67/144 (46%), Gaps = 14/144 (9%)
Query: 495 KRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVN 554
+ VE EL L+ GLG S++G+ +LGIFV+ + EG A RDGR++
Sbjct: 133 RHVEVFEL----LKPPSGGLGFSVVGL---RSENRGELGIFVQEIQEGSVAHRDGRLKET 185
Query: 555 DQIVEVDGISL-VGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQ 613
DQI+ ++G +L +T A ++L+ K V+ VI R + QL+S + +
Sbjct: 186 DQILAINGQALDQTITHQQAISILQKAKDTVQLVIAR------GSLPQLVSPIVSRSPSA 239
Query: 614 RELLEQHYAQYDADDDETGEYATD 637
+ H ET E D
Sbjct: 240 ASTISAHSNPVHWQHMETIELVND 263
Score = 51.6 bits (122), Expect = 4e-06
Identities = 34/107 (31%), Positives = 48/107 (44%), Gaps = 8/107 (7%)
Query: 484 PVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGG 543
P AAS V + +EL D GLG IIG + G+ VKT+ GG
Sbjct: 237 PSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG--------KATGVIVKTILPGG 288
Query: 544 AAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGR 590
A + GR+ D I+++ L G++ A VLR V+ +I R
Sbjct: 289 VADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR 335
Score = 50.8 bits (120), Expect = 7e-06
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 495 KRVEKLELFPVELEKDED-GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQV 553
K E + +EL+K GLG+SI+G G+FV + +GG A DGR+
Sbjct: 1716 KEEEVCDTLTIELQKKPGKGLGLSIVGKR-------NDTGVFVSDIVKGGIADADGRLMQ 1768
Query: 554 NDQIVEVDGISLVGVTQNFAATVLRNTKGNV 584
DQI+ V+G + TQ A +L+ ++G++
Sbjct: 1769 GDQILMVNGEDVRNATQEAVAALLKVSEGSL 1799
Score = 48.5 bits (114), Expect = 3e-05
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 4/129 (3%)
Query: 464 IKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDED-GLGISIIG-- 520
+ +F++Y+ D + + +E + + VEL ++ LGISI+G
Sbjct: 1111 LDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGR 1170
Query: 521 -MGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRN 579
MG G GIF+K V E A ++G ++ D+IVEVDG+ L + A +R
Sbjct: 1171 GMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRK 1230
Query: 580 TKGNVRFVI 588
V F++
Sbjct: 1231 AGNPVVFMV 1239
Score = 47.0 bits (110), Expect = 1e-04
Identities = 30/85 (35%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 505 VELEKDE-DGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGI 563
VE++K D LGISI G GVG+ G + IF+ + G A + +++V D+IV + G
Sbjct: 1834 VEMKKGPTDSLGISIAG-GVGSPLG--DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGT 1890
Query: 564 SLVGVTQNFAATVLRNTKGNVRFVI 588
S G+T A +L+N G++ +
Sbjct: 1891 STEGMTHTQAVNLLKNASGSIEMQV 1915
Score = 45.1 bits (105), Expect = 4e-04
Identities = 35/105 (33%), Positives = 52/105 (49%), Gaps = 11/105 (10%)
Query: 483 DPVAASAEYELEK-----RVEKLELFPVELEKDEDGLGI----SIIGMGVGADAGLEKLG 533
D +EY LE+ E + L V E E + I S +GM V A+ + LG
Sbjct: 973 DSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANK--DGLG 1030
Query: 534 IFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLR 578
+ V+++ GGA RDGRI + D I+ ++ S + VT A +LR
Sbjct: 1031 MIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 3/90 (3%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
+ELEK GLG SI+ D I ++++ GG A++DGR+ D+++ V+ ++
Sbjct: 701 IELEKGSKGLGFSILDYQDPIDPA--STVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVN 758
Query: 565 LVGVTQNFAATVLRNT-KGNVRFVIGREKP 593
L + A L+ G VR + + P
Sbjct: 759 LENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 36.2 bits (82), Expect = 0.17
Identities = 52/251 (20%), Positives = 92/251 (36%), Gaps = 27/251 (10%)
Query: 445 LPEEEEIPANRKIKFSSAPIKVFNTYSNEDY--DRRNDEVDPVAASAEYELEKRVEKLEL 502
L E++ + + +A I N +ED+ RN + P L +E++E
Sbjct: 470 LMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIE- 528
Query: 503 FPVELEKDED----------GLGISIIGMGVGADAGLEKLGI---------FVKTVTEGG 543
+ +K E G+ I+ V + LGI F+++V G
Sbjct: 529 ---DAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEG 585
Query: 544 AAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGRE--KPGQVSEVAQ 601
G++ D+++EV+GI+L+G +L+ V V R P SE+
Sbjct: 586 PVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDS 645
Query: 602 LISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPE 661
L +E + L + + +D + +EV L + I+ EL +
Sbjct: 646 LDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEK 705
Query: 662 NEDMFSPSELD 672
S LD
Sbjct: 706 GSKGLGFSILD 716
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 71.6 bits (174), Expect = 4e-12
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 17/189 (8%)
Query: 496 RVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVND 555
R E ++ +EL K+ DGLGI + G G + I V V EGGAA RDGR+ + D
Sbjct: 326 REEVGRIWKMELLKESDGLGIQVSG---GRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGD 382
Query: 556 QIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRE 615
+++ ++G LVG++ A +LR+ G V+ V+ K ++ +L S++L
Sbjct: 383 ELLVINGHLLVGLSHEEAVAILRSATGMVQLVVA-SKENSAEDLLRLTSKSLPD---LTS 438
Query: 616 LLEQHYAQYDADDDETGEYATDEEEDE-----VGPVLPGSDMAIEVFELPENEDMFSPSE 670
+E + D +D E D EEDE V +PG+D +V E++ +
Sbjct: 439 SVEDVSSWTDNEDQE-----ADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPK 493
Query: 671 LDTSKLSHK 679
++K+ K
Sbjct: 494 QGSNKIKLK 502
Score = 51.6 bits (122), Expect = 4e-06
Identities = 40/159 (25%), Positives = 78/159 (49%), Gaps = 7/159 (4%)
Query: 438 EYSEIV---GLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELE 494
EY+E++ G P + +R + S P + ++ ++++Y ++ +
Sbjct: 517 EYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPW 576
Query: 495 KRVEKLELFPVELEKDED-GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQV 553
+ + + + L K++ GLG SI G G D ++GIFVKT+ G+A DGR++
Sbjct: 577 RLIRPSVISIIGLYKEKGKGLGFSIAG---GRDCIRGQMGIFVKTIFPNGSAAEDGRLKE 633
Query: 554 NDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREK 592
D+I++V+GI + G+T A + + + + R K
Sbjct: 634 GDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/89 (30%), Positives = 51/89 (57%), Gaps = 4/89 (4%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
VE+ K GLG+S+ G G + + +K V +GGAA++ G I+ D+I+ ++G
Sbjct: 2751 VEVLKTSAGLGLSLDG---GKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKP 2807
Query: 565 LVGVTQNFAATVLRNT-KGNVRFVIGREK 592
LVG+ A ++++ +G V+ +I + +
Sbjct: 2808 LVGLMHFDAWNIMKSVPEGPVQLLIRKHR 2836
Score = 41.2 bits (95), Expect = 0.005
Identities = 29/101 (28%), Positives = 56/101 (55%), Gaps = 6/101 (5%)
Query: 519 IGMGVGADA-GLEKL--GIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAAT 575
+G+G+GA LE GI++ ++ G A+ + + DQI+EV+ +++ +
Sbjct: 737 VGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHA 796
Query: 576 VL-RNTKGNVRFVIGREKPGQVS--EVAQLISQTLEQERRQ 613
+L + G VR VIGR +VS E+ ++I+++ QE ++
Sbjct: 797 ILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKE 837
Score = 36.6 bits (83), Expect = 0.13
Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 9/95 (9%)
Query: 487 ASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQ 546
A A+ E E+ V F V K+ GLG S+ G G D +E I V V GAA
Sbjct: 2610 AKAQSENEEDV----CFIVLNRKEGSGLGFSVAG---GTD--VEPKSITVHRVFSQGAAS 2660
Query: 547 RDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTK 581
++G + D ++ V+G SL G+ VL +
Sbjct: 2661 QEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQ 2695
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 70.5 bits (171), Expect = 8e-12
Identities = 38/91 (41%), Positives = 59/91 (64%), Gaps = 4/91 (4%)
Query: 501 ELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEV 560
E+ V L+K ++G+G+SI+ AG +KLGI+VK+V +GGAA DGR+ DQ++ V
Sbjct: 1005 EIITVTLKK-QNGMGLSIVA---AKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSV 1060
Query: 561 DGISLVGVTQNFAATVLRNTKGNVRFVIGRE 591
DG SLVG++Q AA ++ T V + ++
Sbjct: 1061 DGRSLVGLSQERAAELMTRTSSVVTLEVAKQ 1091
Score = 34.3 bits (77), Expect = 0.66
Identities = 69/360 (19%), Positives = 136/360 (37%), Gaps = 59/360 (16%)
Query: 593 PGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDM 652
P +++ +Q ERR+RE ++ Y + A +E E E+E ++G + S
Sbjct: 1390 PPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQS-- 1447
Query: 653 AIEVFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWE 712
N FSP K K LQ E+Q + +
Sbjct: 1448 --------LNPAPFSPLTAQQMK-PEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYIT 1498
Query: 713 LEKTQLQQNIEENKERMLKLESYWIEAQTLCHTV---NEHLKETQSQYQALEKKYNKAKK 769
+ K +L + + + +E Q H V ++ ++E QS+ ++ ++ +K
Sbjct: 1499 VSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRK 1558
Query: 770 LIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVN 829
L+ ++Q F KR + ++K ED E+ +V + + R LEAE
Sbjct: 1559 LMLEWQ-----FQKRLQESKQKDEDDEEEEDDDVDTMLIMQR-LEAE------------- 1599
Query: 830 NNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQL 889
RT++ +S D +++ + ++ + E + + + RA+
Sbjct: 1600 -----RRARTAMPAISVLDLLQDEERRRQQ--------------QLEEMRKREAEDRARQ 1640
Query: 890 SVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGL 949
+ RRQ RT+ D E+ ++ ++ + + + EP+ PGL
Sbjct: 1641 EEERRRQEEERTK-------RDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGL 1693
>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 2 [Homo
sapiens]
Length = 1651
Score = 70.5 bits (171), Expect = 8e-12
Identities = 38/91 (41%), Positives = 59/91 (64%), Gaps = 4/91 (4%)
Query: 501 ELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEV 560
E+ V L+K ++G+G+SI+ AG +KLGI+VK+V +GGAA DGR+ DQ++ V
Sbjct: 1006 EIITVTLKK-QNGMGLSIVA---AKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSV 1061
Query: 561 DGISLVGVTQNFAATVLRNTKGNVRFVIGRE 591
DG SLVG++Q AA ++ T V + ++
Sbjct: 1062 DGRSLVGLSQERAAELMTRTSSVVTLEVAKQ 1092
Score = 33.9 bits (76), Expect = 0.87
Identities = 49/228 (21%), Positives = 95/228 (41%), Gaps = 17/228 (7%)
Query: 593 PGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDM 652
P +++ +Q ERR+RE ++ Y + A +E E E+E ++G + S
Sbjct: 1391 PPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQS-- 1448
Query: 653 AIEVFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWE 712
N FSP K K LQ E+Q + +
Sbjct: 1449 --------LNPAPFSPLTAQQMK-PEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYIT 1499
Query: 713 LEKTQLQQNIEENKERMLKLESYWIEAQTLCHTV---NEHLKETQSQYQALEKKYNKAKK 769
+ K +L + + + +E Q H V ++ ++E QS+ ++ ++ +K
Sbjct: 1500 VSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRK 1559
Query: 770 LIKDFQ-QKELDFIKRQEAERKKIEDLEKAHLVEVQGLQV--RIRDLE 814
L+ ++Q QK L K+++ + ++ ED + ++ +Q L+ R RD E
Sbjct: 1560 LMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARDEE 1607
>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 3 [Homo
sapiens]
Length = 1612
Score = 70.5 bits (171), Expect = 8e-12
Identities = 38/91 (41%), Positives = 59/91 (64%), Gaps = 4/91 (4%)
Query: 501 ELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEV 560
E+ V L+K ++G+G+SI+ AG +KLGI+VK+V +GGAA DGR+ DQ++ V
Sbjct: 990 EIITVTLKK-QNGMGLSIVA---AKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSV 1045
Query: 561 DGISLVGVTQNFAATVLRNTKGNVRFVIGRE 591
DG SLVG++Q AA ++ T V + ++
Sbjct: 1046 DGRSLVGLSQERAAELMTRTSSVVTLEVAKQ 1076
Score = 33.5 bits (75), Expect = 1.1
Identities = 50/227 (22%), Positives = 92/227 (40%), Gaps = 20/227 (8%)
Query: 593 PGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDM 652
P +++ +Q ERR+RE ++ Y + A +E E E+E ++G + S
Sbjct: 1375 PPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQS-- 1432
Query: 653 AIEVFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWE 712
N FSP K K LQ E+Q + +
Sbjct: 1433 --------LNPAPFSPLTAQQMK-PEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYIT 1483
Query: 713 LEKTQLQQNIEENKERMLKLESYWIEAQTLCHTV---NEHLKETQSQYQALEKKYNKAKK 769
+ K +L + + + +E Q H V ++ ++E QS+ ++ ++ +K
Sbjct: 1484 VSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRK 1543
Query: 770 LIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAE 816
L+ ++Q F KR + ++K ED E+ +V + + R LEAE
Sbjct: 1544 LMLEWQ-----FQKRLQESKQKDEDDEEEEDDDVDTMLIMQR-LEAE 1584
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 70.1 bits (170), Expect = 1e-11
Identities = 39/98 (39%), Positives = 59/98 (60%), Gaps = 8/98 (8%)
Query: 498 EKLELFPVELEKDED-GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQ 556
E LE+FPV+L+K GLG+SI+G G+ G+F+ + +GGAA DGR+ DQ
Sbjct: 1527 ENLEIFPVDLQKKAGRGLGLSIVGKRNGS-------GVFISDIVKGGAADLDGRLIQGDQ 1579
Query: 557 IVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPG 594
I+ V+G + +Q AT+L+ +G V+ IGR + G
Sbjct: 1580 ILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAG 1617
Score = 67.4 bits (163), Expect = 7e-11
Identities = 35/93 (37%), Positives = 51/93 (54%), Gaps = 8/93 (8%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
VEL D GLG I+G G+ V+T+ GG A RDGR+Q D I+++ G +
Sbjct: 249 VELINDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGREKPGQVS 597
+ G+T A VLRN +VR ++ R+ G +S
Sbjct: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDIS 333
Score = 65.9 bits (159), Expect = 2e-10
Identities = 60/183 (32%), Positives = 90/183 (49%), Gaps = 14/183 (7%)
Query: 416 ETGTE--QDEEEDSDENSYYQ-PDMEYSEI-VGLPEEEEIPANRKIKFSSA--PIKVFNT 469
++GTE EE+ S E Q P+ E ++ V ++++ P K+ FSS P+ ++
Sbjct: 1346 QSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPT--KVSFSSQEIPLAPASS 1403
Query: 470 YSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGL 529
Y + D D S + V E+ +E+ K GLG+SI+G G D L
Sbjct: 1404 YHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMI-IEISKGRSGLGLSIVG---GKDTPL 1459
Query: 530 EKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIG 589
I + V E GAA RDGR+ DQI+EV+G+ L + A T LR T VR V+
Sbjct: 1460 N--AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY 1517
Query: 590 REK 592
R++
Sbjct: 1518 RDE 1520
Score = 64.7 bits (156), Expect = 5e-10
Identities = 40/93 (43%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Query: 501 ELFPVEL-EKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVE 559
E + VEL KD LGI I+G VG E GI+VK++ G AA +G IQVND+IV
Sbjct: 362 ETYNVELVRKDGQSLGIRIVGY-VGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVA 420
Query: 560 VDGISLVGVTQNFAATVLRNTKGNVRFVIGREK 592
VDG+++ G + VLRN V + R K
Sbjct: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRK 453
Score = 57.0 bits (136), Expect = 1e-07
Identities = 33/116 (28%), Positives = 63/116 (54%), Gaps = 7/116 (6%)
Query: 479 NDEVDPVAASAEYELEKRVEKL--ELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFV 536
+DE + A + ++ +R L EL +ELEKD++GLG+S+ G + ++ IFV
Sbjct: 1212 SDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAG-----NKDRSRMSIFV 1266
Query: 537 KTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREK 592
+ G A DGR+++ D+++E++ L G + A+ +++ V+ V R +
Sbjct: 1267 VGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNE 1322
Score = 51.2 bits (121), Expect = 5e-06
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 513 GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISL-VGVTQN 571
GLG S++ + L K+ IFVK V G A RD R++ NDQI+ ++ L ++
Sbjct: 144 GLGFSVVAL---RSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQ 200
Query: 572 FAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQT 606
A +L+ T G++R ++ RE S + ++ T
Sbjct: 201 QAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDT 235
Score = 44.7 bits (104), Expect = 5e-04
Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 11/103 (10%)
Query: 483 DPVAASAEYELEKRVEKLELFPVELEKD-EDGLGISIIGMGVGADAGLEKLGIFVKTVTE 541
DP ++ ++E R VE+ ++ D LGISI G G + L + +F+ +
Sbjct: 1662 DPSQKNSGTDMEPRT-------VEINRELSDALGISIAG---GRGSPLGDIPVFIAMIQA 1711
Query: 542 GGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNV 584
G A R +++V D+IV ++G L G++ +L+N G +
Sbjct: 1712 SGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRI 1754
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/185 (24%), Positives = 78/185 (42%), Gaps = 21/185 (11%)
Query: 514 LGISIIGMGVGADA---GLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQ 570
LGISI+G G E GIF+K V E A + ++ D+I+EV G+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
Query: 571 NFAATVLRNTKGNVRFVIG--REKPGQVSEV---AQLISQTLEQERRQRELLEQHYA--- 622
+ A ++N V F++ P + V A I+ Q+ ++++ Q A
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
Query: 623 ----------QYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPSELD 672
D+D++E + TD++ + LPG IE+ + + D
Sbjct: 1199 MKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKD 1258
Query: 673 TSKLS 677
S++S
Sbjct: 1259 RSRMS 1263
Score = 36.2 bits (82), Expect = 0.17
Identities = 40/174 (22%), Positives = 72/174 (41%), Gaps = 27/174 (15%)
Query: 480 DEVDPVAASAEYELEKRVEKLELFP----------------VELEKDEDGLGISIIGMGV 523
++++ V S E EL+ R E L L P EL+K L I + +GV
Sbjct: 514 EKLEKVPDSPENELKSRWENL-LGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 524 GADA--GLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTK 581
D+ G ++ ++ GG G +Q D+++EV+G+ L G ++ A + L+
Sbjct: 573 EVDSFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP 628
Query: 582 GNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYA 635
V R ++ + + + E E H + ++D+ GE A
Sbjct: 629 PPFTLVCCR----RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELA 678
Score = 31.2 bits (69), Expect = 5.6
Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 2/74 (2%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
VEL KD GLG SI+ D + I ++++ G A+R G + D++V V+
Sbjct: 687 VELVKDCKGLGFSILDYQDPLDP--TRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYC 744
Query: 565 LVGVTQNFAATVLR 578
L + A +L+
Sbjct: 745 LDNTSLAEAVEILK 758
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 67.8 bits (164), Expect = 5e-11
Identities = 41/114 (35%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 501 ELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEV 560
++F VEL K+++ LGIS+ G G + + GI+VK V GAA+ DGRI D+++ V
Sbjct: 1174 DIFEVELAKNDNSLGISVTG---GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1230
Query: 561 DGISLVGVTQNFAATVLRNTKGNVRFVIGR-EKPGQVSEVAQLISQTLEQERRQ 613
+G+SL G T A LRNT V ++ + + P V TL + Q
Sbjct: 1231 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1284
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/93 (38%), Positives = 53/93 (56%), Gaps = 4/93 (4%)
Query: 501 ELFPVELEKDED-GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVE 559
E+ V L+KD GLG IIG G G LGIF+ +V GG A DG ++ D+++
Sbjct: 899 EITLVNLKKDAKYGLGFQIIG---GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 955
Query: 560 VDGISLVGVTQNFAATVLRNTKGNVRFVIGREK 592
V+ +SL GV+ + A +L+N +V VI + K
Sbjct: 956 VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK 988
Score = 51.2 bits (121), Expect = 5e-06
Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 11/167 (6%)
Query: 503 FPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDG 562
F V+L K+ GLG S + + VK + G A G+I V D I++V+G
Sbjct: 1309 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1368
Query: 563 ISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYA 622
SL G++Q + LR T V ++ R PG + E+ + L+ ++L +
Sbjct: 1369 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQS---PAQVLPN--S 1423
Query: 623 QYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPS 669
D+ E +T +E+E+ SD + + + P D +S S
Sbjct: 1424 SKDSSQPSCVEQSTSSDENEM------SDKSKKQCKSPSRRDSYSDS 1464
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 67.8 bits (164), Expect = 5e-11
Identities = 41/114 (35%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 501 ELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEV 560
++F VEL K+++ LGIS+ G G + + GI+VK V GAA+ DGRI D+++ V
Sbjct: 1365 DIFEVELAKNDNSLGISVTG---GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1421
Query: 561 DGISLVGVTQNFAATVLRNTKGNVRFVIGR-EKPGQVSEVAQLISQTLEQERRQ 613
+G+SL G T A LRNT V ++ + + P V TL + Q
Sbjct: 1422 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1475
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/93 (38%), Positives = 53/93 (56%), Gaps = 4/93 (4%)
Query: 501 ELFPVELEKDED-GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVE 559
E+ V L+KD GLG IIG G G LGIF+ +V GG A DG ++ D+++
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIG---GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1146
Query: 560 VDGISLVGVTQNFAATVLRNTKGNVRFVIGREK 592
V+ +SL GV+ + A +L+N +V VI + K
Sbjct: 1147 VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK 1179
Score = 51.2 bits (121), Expect = 5e-06
Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 11/167 (6%)
Query: 503 FPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDG 562
F V+L K+ GLG S + + VK + G A G+I V D I++V+G
Sbjct: 1500 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1559
Query: 563 ISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYA 622
SL G++Q + LR T V ++ R PG + E+ + L+ ++L +
Sbjct: 1560 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQS---PAQVLPN--S 1614
Query: 623 QYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPS 669
D+ E +T +E+E+ SD + + + P D +S S
Sbjct: 1615 SKDSSQPSCVEQSTSSDENEM------SDKSKKQCKSPSRRDSYSDS 1655
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 67.8 bits (164), Expect = 5e-11
Identities = 41/114 (35%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 501 ELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEV 560
++F VEL K+++ LGIS+ G G + + GI+VK V GAA+ DGRI D+++ V
Sbjct: 1346 DIFEVELAKNDNSLGISVTG---GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1402
Query: 561 DGISLVGVTQNFAATVLRNTKGNVRFVIGR-EKPGQVSEVAQLISQTLEQERRQ 613
+G+SL G T A LRNT V ++ + + P V TL + Q
Sbjct: 1403 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1456
Score = 60.8 bits (146), Expect = 7e-09
Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 17/172 (9%)
Query: 435 PDMEYSEIVGLP-------EEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEV-DPVA 486
P +E+VG P + E + K+ S + + + ++ + + DP
Sbjct: 992 PPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQ 1051
Query: 487 ASAEYELEKRVE-----KLELFPVELEKDED-GLGISIIGMGVGADAGLEKLGIFVKTVT 540
A L KR + E+ V L+KD GLG IIG G G LGIF+ +V
Sbjct: 1052 AYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIG---GEKMGRLDLGIFISSVA 1108
Query: 541 EGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREK 592
GG A DG ++ D+++ V+ +SL GV+ + A +L+N +V VI + K
Sbjct: 1109 PGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK 1160
Score = 51.2 bits (121), Expect = 5e-06
Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 11/167 (6%)
Query: 503 FPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDG 562
F V+L K+ GLG S + + VK + G A G+I V D I++V+G
Sbjct: 1481 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1540
Query: 563 ISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYA 622
SL G++Q + LR T V ++ R PG + E+ + L+ ++L +
Sbjct: 1541 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQS---PAQVLPN--S 1595
Query: 623 QYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPS 669
D+ E +T +E+E+ SD + + + P D +S S
Sbjct: 1596 SKDSSQPSCVEQSTSSDENEM------SDKSKKQCKSPSRRDSYSDS 1636
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 63.9 bits (154), Expect = 8e-10
Identities = 51/176 (28%), Positives = 84/176 (47%), Gaps = 13/176 (7%)
Query: 441 EIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKL 500
++VG +EE + R K + + + + R +P E + E +
Sbjct: 518 DLVGKSQEEVVSLLRSTKMEGT-VSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDI 576
Query: 501 ELFP------VELEKDEDGLGISIIGMGVGADAGLEK---LGIFVKTVTEGGAAQRDGRI 551
L P + E + G + +G+ V + E LGIFVK++ GGAA +DGR+
Sbjct: 577 VLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRL 636
Query: 552 QVNDQIVEVDGISLVGVTQNFAATVLR---NTKGNVRFVIGREKPGQVSEVAQLIS 604
+VNDQ++ V+G SL+G T A LR +T+GN R +I ++S+ +L S
Sbjct: 637 RVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKS 692
Score = 60.5 bits (145), Expect = 9e-09
Identities = 41/135 (30%), Positives = 71/135 (52%), Gaps = 24/135 (17%)
Query: 460 SSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISII 519
+SAP VF+T + Y+ + ++ KR+ ++L+K +GLG SI
Sbjct: 436 ASAPQNVFSTTVSSGYNTK-------------KIGKRLN------IQLKKGTEGLGFSIT 476
Query: 520 GMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRN 579
V I+VK + GAA +DGR++ D+++EV+G+ LVG +Q ++LR+
Sbjct: 477 SRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
Query: 580 TK--GNVRFVIGREK 592
TK G V ++ R++
Sbjct: 534 TKMEGTVSLLVFRQE 548
Score = 32.0 bits (71), Expect = 3.3
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 3/57 (5%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVD 561
VE+ D LGI ++ G LG+ VK + +GG A+ + + ND IV ++
Sbjct: 275 VEVPNDGGPLGIHVVPFSA---RGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRIN 328
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 63.5 bits (153), Expect = 1e-09
Identities = 40/116 (34%), Positives = 61/116 (52%), Gaps = 3/116 (2%)
Query: 501 ELFPVELEKDEDGLGISIIGM--GVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIV 558
++F VEL K+++ LGIS+ + G + + GI+VK V GAA+ DGRI D+++
Sbjct: 1365 DIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 1424
Query: 559 EVDGISLVGVTQNFAATVLRNTKGNVRFVIGR-EKPGQVSEVAQLISQTLEQERRQ 613
V+G+SL G T A LRNT V ++ + + P V TL + Q
Sbjct: 1425 AVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1480
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/93 (38%), Positives = 53/93 (56%), Gaps = 4/93 (4%)
Query: 501 ELFPVELEKDED-GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVE 559
E+ V L+KD GLG IIG G G LGIF+ +V GG A DG ++ D+++
Sbjct: 1090 EITLVNLKKDAKYGLGFQIIG---GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1146
Query: 560 VDGISLVGVTQNFAATVLRNTKGNVRFVIGREK 592
V+ +SL GV+ + A +L+N +V VI + K
Sbjct: 1147 VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK 1179
Score = 51.2 bits (121), Expect = 5e-06
Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 11/167 (6%)
Query: 503 FPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDG 562
F V+L K+ GLG S + + VK + G A G+I V D I++V+G
Sbjct: 1505 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1564
Query: 563 ISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYA 622
SL G++Q + LR T V ++ R PG + E+ + L+ ++L +
Sbjct: 1565 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQS---PAQVLPN--S 1619
Query: 623 QYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPS 669
D+ E +T +E+E+ SD + + + P D +S S
Sbjct: 1620 SKDSSQPSCVEQSTSSDENEM------SDKSKKQCKSPSRRDSYSDS 1660
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 62.0 bits (149), Expect = 3e-09
Identities = 96/440 (21%), Positives = 187/440 (42%), Gaps = 77/440 (17%)
Query: 658 ELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQ 717
E+ ED ++ K ++ KEL+ KH+ E L+ +LQA +T+
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA-----------ETE 901
Query: 718 LQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQK 777
L EE + R+ + E + + H + L+E + + Q L+ + K + + D +++
Sbjct: 902 LYAEAEEMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 778 ELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFER 837
++ +EA R+K++ LEK + +I+ LE E+ + QN +++ + E
Sbjct: 959 ----LEEEEAARQKLQ-LEKV------TAEAKIKKLEDEILVMDDQN-NKLSKERKLLEE 1006
Query: 838 RTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQR 897
R S D NL ++ E +L +K ++L V+ +++
Sbjct: 1007 RIS-------DLTTNLAEEE------------EKAKNLTKLKNKHESMISELEVRLKKEE 1047
Query: 898 PSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSS 957
SR L + L+RK D S ADL AE L LA
Sbjct: 1048 KSRQEL----------EKLKRK---LEGDASDFHEQIADLQAQIAE-----LKMQLAKKE 1089
Query: 958 DE---SLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNI 1014
+E +L +DDEI + K++ + E + + L S + +E +++
Sbjct: 1090 EELQAALARLDDEI-----AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 1015 TGEQLLQLDGNKLKALGMTASQD--RAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRK 1072
GE+L L L TA+Q RA ++++ +K +L++ ++ E Q +++R+K
Sbjct: 1145 -GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH---EAQVQEMRQK 1200
Query: 1073 EQEQMQRKSKKTEKMTSTTA 1092
+ ++ +++ E+ A
Sbjct: 1201 HAQAVEELTEQLEQFKRAKA 1220
Score = 55.5 bits (132), Expect = 3e-07
Identities = 102/521 (19%), Positives = 210/521 (40%), Gaps = 78/521 (14%)
Query: 601 QLISQTLEQERRQRELL--EQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFE 658
QL+S +++R+ +LL E++ + AD+ + E E+E + + + A+E E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 659 ---------LPENEDMFSPSELDTSKLSHKFKE----LQIKHAVTEAEIQKLKTKLQAAE 705
E ED+ S + D K H+ ++ L+ + + ++++L+ +LQA E
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 706 NEKVRWELE--------KTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQY 757
+ K+R E+ + LQ E+N+E+ +L Q H L++ + Q
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-------QRQLHEYETELEDERKQR 1612
Query: 758 QALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEA-- 815
K + +KD + + IK +E K++ L+ +++ Q + D A
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ----AQMKDFQRELEDARASR 1668
Query: 816 -EVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPE 874
E+F K+N E++ E E+L + + + +A E
Sbjct: 1669 DEIFATAKEN-----------EKKAKSLEADLMQLQEDLAAAERARK--------QADLE 1709
Query: 875 TERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSS 934
E L A + + LS +N Q R RL ++ + E E+ N D +T
Sbjct: 1710 KEEL---AEELASSLSGRNALQDEKR-RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 935 ADL--SGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQ 992
A+ + L E T ++S + + ++ + + K A E + Q
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 993 VSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSL 1052
LE+ V + + + + L+ KLK + + +R + ++ ++ +
Sbjct: 1826 ---------LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Query: 1053 EKARKAQEKMEKQREKL------RRKEQEQMQRKSKKTEKM 1087
+ ++ + ++E+ E+ RRK Q ++ ++ E M
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 47.8 bits (112), Expect = 6e-05
Identities = 82/397 (20%), Positives = 150/397 (37%), Gaps = 68/397 (17%)
Query: 591 EKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGS 650
EK Q+ LE ER+QR L + + D + E + + G
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD--------LKDLELQADSAIKGR 1640
Query: 651 DMAIEVFELPENEDMFSPSELDTSKLSHK-----FKELQIKHAVTEAEIQKLKTKLQAAE 705
+ AI+ + + EL+ ++ S KE + K EA++ +L+ L AAE
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 706 NEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYN 765
+ + +LEK +L + + + L+ + + E L+E Q +A+ +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 766 KA--------KKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVE----------VQGLQ 807
KA +L + + + RQ+ ER+ E K H +E + L+
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 808 VRIRDLEAEV----------FRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTME-NLDGK 856
+I LE +V + LKQ ++ E + E K + N K
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 857 QTSCQDGLSQDLNEAVPETERLDSKALKTRAQL---------------SVKNRRQRPSRT 901
Q L + L EA E++R+++ K + +L ++K++ +R + T
Sbjct: 1881 Q------LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET 1934
Query: 902 RLYDSVSS-----TDGEDSLERKNFTFNDDFSPSSTS 933
S S + D E + T + DF+ + S
Sbjct: 1935 SFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKAS 1971
Score = 44.3 bits (103), Expect = 6e-04
Identities = 100/522 (19%), Positives = 202/522 (38%), Gaps = 57/522 (10%)
Query: 590 REKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGP--VL 647
R QV E+ Q +Q +E+ Q E + + A+ D+ + E D G VL
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLE----QFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 648 PGSDMAIE------VFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKL 701
+ +E ++ E + S E ++L+ K +LQ E++ + L
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-------NEVESVTGML 1296
Query: 702 QAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQY---- 757
AE + ++ + L +++ +E + + + T + E Q Q
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 758 ---QALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLE 814
Q LE+ + + D ++K DF EA +E+ +K E++ L + +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA----LEEGKKRFQKEIENLTQQYEEKA 1412
Query: 815 AEVFRLLK-QNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVP 873
A +L K +N Q ++ + + VS NL+ KQ + ++ +
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS------NLEKKQ--------RKFDQLLA 1458
Query: 874 ETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSV-SSTDGEDSLERKNFTFNDDFSPSST 932
E + + SK R + + R + L ++ + + ++ LER N + +
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 933 SSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQ 992
S D +G S+ + E + +E+ D+ Q+ + ++ + + Q
Sbjct: 1519 SKDD---VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 993 VSHWLMSLNLEQYVSEFSAQNITGEQLLQL-DGNKLKALGMTASQDRAVVKKKLKEMKMS 1051
L + + + Q E +L D K +AL A + ++ LK++++
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK---LEGDLKDLELQ 1632
Query: 1052 LEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMTSTTAE 1093
+ A K +E+ KQ KL Q QM+ ++ E ++ E
Sbjct: 1633 ADSAIKGREEAIKQLRKL----QAQMKDFQRELEDARASRDE 1670
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 62.0 bits (149), Expect = 3e-09
Identities = 96/440 (21%), Positives = 187/440 (42%), Gaps = 77/440 (17%)
Query: 658 ELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQ 717
E+ ED ++ K ++ KEL+ KH+ E L+ +LQA +T+
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA-----------ETE 908
Query: 718 LQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQK 777
L EE + R+ + E + + H + L+E + + Q L+ + K + + D +++
Sbjct: 909 LYAEAEEMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 778 ELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFER 837
++ +EA R+K++ LEK + +I+ LE E+ + QN +++ + E
Sbjct: 966 ----LEEEEAARQKLQ-LEKV------TAEAKIKKLEDEILVMDDQN-NKLSKERKLLEE 1013
Query: 838 RTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQR 897
R S D NL ++ E +L +K ++L V+ +++
Sbjct: 1014 RIS-------DLTTNLAEEE------------EKAKNLTKLKNKHESMISELEVRLKKEE 1054
Query: 898 PSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSS 957
SR L + L+RK D S ADL AE L LA
Sbjct: 1055 KSRQEL----------EKLKRK---LEGDASDFHEQIADLQAQIAE-----LKMQLAKKE 1096
Query: 958 DE---SLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNI 1014
+E +L +DDEI + K++ + E + + L S + +E +++
Sbjct: 1097 EELQAALARLDDEI-----AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 1015 TGEQLLQLDGNKLKALGMTASQD--RAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRK 1072
GE+L L L TA+Q RA ++++ +K +L++ ++ E Q +++R+K
Sbjct: 1152 -GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH---EAQVQEMRQK 1207
Query: 1073 EQEQMQRKSKKTEKMTSTTA 1092
+ ++ +++ E+ A
Sbjct: 1208 HAQAVEELTEQLEQFKRAKA 1227
Score = 55.5 bits (132), Expect = 3e-07
Identities = 102/521 (19%), Positives = 210/521 (40%), Gaps = 78/521 (14%)
Query: 601 QLISQTLEQERRQRELL--EQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFE 658
QL+S +++R+ +LL E++ + AD+ + E E+E + + + A+E E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 659 ---------LPENEDMFSPSELDTSKLSHKFKE----LQIKHAVTEAEIQKLKTKLQAAE 705
E ED+ S + D K H+ ++ L+ + + ++++L+ +LQA E
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 706 NEKVRWELE--------KTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQY 757
+ K+R E+ + LQ E+N+E+ +L Q H L++ + Q
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-------QRQLHEYETELEDERKQR 1619
Query: 758 QALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEA-- 815
K + +KD + + IK +E K++ L+ +++ Q + D A
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ----AQMKDFQRELEDARASR 1675
Query: 816 -EVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPE 874
E+F K+N E++ E E+L + + + +A E
Sbjct: 1676 DEIFATAKEN-----------EKKAKSLEADLMQLQEDLAAAERARK--------QADLE 1716
Query: 875 TERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSS 934
E L A + + LS +N Q R RL ++ + E E+ N D +T
Sbjct: 1717 KEEL---AEELASSLSGRNALQDEKR-RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 935 ADL--SGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQ 992
A+ + L E T ++S + + ++ + + K A E + Q
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 993 VSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSL 1052
LE+ V + + + + L+ KLK + + +R + ++ ++ +
Sbjct: 1833 ---------LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Query: 1053 EKARKAQEKMEKQREKL------RRKEQEQMQRKSKKTEKM 1087
+ ++ + ++E+ E+ RRK Q ++ ++ E M
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 47.8 bits (112), Expect = 6e-05
Identities = 82/397 (20%), Positives = 150/397 (37%), Gaps = 68/397 (17%)
Query: 591 EKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGS 650
EK Q+ LE ER+QR L + + D + E + + G
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD--------LKDLELQADSAIKGR 1647
Query: 651 DMAIEVFELPENEDMFSPSELDTSKLSHK-----FKELQIKHAVTEAEIQKLKTKLQAAE 705
+ AI+ + + EL+ ++ S KE + K EA++ +L+ L AAE
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 706 NEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYN 765
+ + +LEK +L + + + L+ + + E L+E Q +A+ +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 766 KA--------KKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVE----------VQGLQ 807
KA +L + + + RQ+ ER+ E K H +E + L+
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 808 VRIRDLEAEV----------FRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTME-NLDGK 856
+I LE +V + LKQ ++ E + E K + N K
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 857 QTSCQDGLSQDLNEAVPETERLDSKALKTRAQL---------------SVKNRRQRPSRT 901
Q L + L EA E++R+++ K + +L ++K++ +R + T
Sbjct: 1888 Q------LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET 1941
Query: 902 RLYDSVSS-----TDGEDSLERKNFTFNDDFSPSSTS 933
S S + D E + T + DF+ + S
Sbjct: 1942 SFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKAS 1978
Score = 44.3 bits (103), Expect = 6e-04
Identities = 100/522 (19%), Positives = 202/522 (38%), Gaps = 57/522 (10%)
Query: 590 REKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGP--VL 647
R QV E+ Q +Q +E+ Q E + + A+ D+ + E D G VL
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLE----QFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 648 PGSDMAIE------VFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKL 701
+ +E ++ E + S E ++L+ K +LQ E++ + L
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-------NEVESVTGML 1303
Query: 702 QAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQY---- 757
AE + ++ + L +++ +E + + + T + E Q Q
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 758 ---QALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLE 814
Q LE+ + + D ++K DF EA +E+ +K E++ L + +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA----LEEGKKRFQKEIENLTQQYEEKA 1419
Query: 815 AEVFRLLK-QNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVP 873
A +L K +N Q ++ + + VS NL+ KQ + ++ +
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS------NLEKKQ--------RKFDQLLA 1465
Query: 874 ETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSV-SSTDGEDSLERKNFTFNDDFSPSST 932
E + + SK R + + R + L ++ + + ++ LER N + +
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 933 SSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQ 992
S D +G S+ + E + +E+ D+ Q+ + ++ + + Q
Sbjct: 1526 SKDD---VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 993 VSHWLMSLNLEQYVSEFSAQNITGEQLLQL-DGNKLKALGMTASQDRAVVKKKLKEMKMS 1051
L + + + Q E +L D K +AL A + ++ LK++++
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK---LEGDLKDLELQ 1639
Query: 1052 LEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMTSTTAE 1093
+ A K +E+ KQ KL Q QM+ ++ E ++ E
Sbjct: 1640 ADSAIKGREEAIKQLRKL----QAQMKDFQRELEDARASRDE 1677
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 62.0 bits (149), Expect = 3e-09
Identities = 96/440 (21%), Positives = 187/440 (42%), Gaps = 77/440 (17%)
Query: 658 ELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQ 717
E+ ED ++ K ++ KEL+ KH+ E L+ +LQA +T+
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA-----------ETE 908
Query: 718 LQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQK 777
L EE + R+ + E + + H + L+E + + Q L+ + K + + D +++
Sbjct: 909 LYAEAEEMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 778 ELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFER 837
++ +EA R+K++ LEK + +I+ LE E+ + QN +++ + E
Sbjct: 966 ----LEEEEAARQKLQ-LEKV------TAEAKIKKLEDEILVMDDQN-NKLSKERKLLEE 1013
Query: 838 RTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQR 897
R S D NL ++ E +L +K ++L V+ +++
Sbjct: 1014 RIS-------DLTTNLAEEE------------EKAKNLTKLKNKHESMISELEVRLKKEE 1054
Query: 898 PSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSS 957
SR L + L+RK D S ADL AE L LA
Sbjct: 1055 KSRQEL----------EKLKRK---LEGDASDFHEQIADLQAQIAE-----LKMQLAKKE 1096
Query: 958 DE---SLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNI 1014
+E +L +DDEI + K++ + E + + L S + +E +++
Sbjct: 1097 EELQAALARLDDEI-----AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 1015 TGEQLLQLDGNKLKALGMTASQD--RAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRK 1072
GE+L L L TA+Q RA ++++ +K +L++ ++ E Q +++R+K
Sbjct: 1152 -GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH---EAQVQEMRQK 1207
Query: 1073 EQEQMQRKSKKTEKMTSTTA 1092
+ ++ +++ E+ A
Sbjct: 1208 HAQAVEELTEQLEQFKRAKA 1227
Score = 55.5 bits (132), Expect = 3e-07
Identities = 102/521 (19%), Positives = 210/521 (40%), Gaps = 78/521 (14%)
Query: 601 QLISQTLEQERRQRELL--EQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFE 658
QL+S +++R+ +LL E++ + AD+ + E E+E + + + A+E E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 659 ---------LPENEDMFSPSELDTSKLSHKFKE----LQIKHAVTEAEIQKLKTKLQAAE 705
E ED+ S + D K H+ ++ L+ + + ++++L+ +LQA E
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 706 NEKVRWELE--------KTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQY 757
+ K+R E+ + LQ E+N+E+ +L Q H L++ + Q
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-------QRQLHEYETELEDERKQR 1619
Query: 758 QALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEA-- 815
K + +KD + + IK +E K++ L+ +++ Q + D A
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ----AQMKDFQRELEDARASR 1675
Query: 816 -EVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPE 874
E+F K+N E++ E E+L + + + +A E
Sbjct: 1676 DEIFATAKEN-----------EKKAKSLEADLMQLQEDLAAAERARK--------QADLE 1716
Query: 875 TERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSS 934
E L A + + LS +N Q R RL ++ + E E+ N D +T
Sbjct: 1717 KEEL---AEELASSLSGRNALQDEKR-RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 935 ADL--SGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQ 992
A+ + L E T ++S + + ++ + + K A E + Q
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 993 VSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSL 1052
LE+ V + + + + L+ KLK + + +R + ++ ++ +
Sbjct: 1833 ---------LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Query: 1053 EKARKAQEKMEKQREKL------RRKEQEQMQRKSKKTEKM 1087
+ ++ + ++E+ E+ RRK Q ++ ++ E M
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 47.4 bits (111), Expect = 8e-05
Identities = 71/333 (21%), Positives = 128/333 (38%), Gaps = 48/333 (14%)
Query: 591 EKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGS 650
EK Q+ LE ER+QR L + + D + E + + G
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD--------LKDLELQADSAIKGR 1647
Query: 651 DMAIEVFELPENEDMFSPSELDTSKLSHK-----FKELQIKHAVTEAEIQKLKTKLQAAE 705
+ AI+ + + EL+ ++ S KE + K EA++ +L+ L AAE
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 706 NEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYN 765
+ + +LEK +L + + + L+ + + E L+E Q +A+ +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 766 KA--------KKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVE----------VQGLQ 807
KA +L + + + RQ+ ER+ E K H +E + L+
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 808 VRIRDLEAEV----------FRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTME-NLDGK 856
+I LE +V + LKQ ++ E + E K + N K
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 857 QTSCQDGLSQDLNEAVPETERLDSKALKTRAQL 889
Q L + L EA E++R+++ K + +L
Sbjct: 1888 Q------LKRQLEEAEEESQRINANRRKLQREL 1914
Score = 44.3 bits (103), Expect = 6e-04
Identities = 100/522 (19%), Positives = 202/522 (38%), Gaps = 57/522 (10%)
Query: 590 REKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGP--VL 647
R QV E+ Q +Q +E+ Q E + + A+ D+ + E D G VL
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLE----QFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 648 PGSDMAIE------VFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKL 701
+ +E ++ E + S E ++L+ K +LQ E++ + L
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-------NEVESVTGML 1303
Query: 702 QAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQY---- 757
AE + ++ + L +++ +E + + + T + E Q Q
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 758 ---QALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLE 814
Q LE+ + + D ++K DF EA +E+ +K E++ L + +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA----LEEGKKRFQKEIENLTQQYEEKA 1419
Query: 815 AEVFRLLK-QNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVP 873
A +L K +N Q ++ + + VS NL+ KQ + ++ +
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS------NLEKKQ--------RKFDQLLA 1465
Query: 874 ETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSV-SSTDGEDSLERKNFTFNDDFSPSST 932
E + + SK R + + R + L ++ + + ++ LER N + +
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 933 SSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQ 992
S D +G S+ + E + +E+ D+ Q+ + ++ + + Q
Sbjct: 1526 SKDD---VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 993 VSHWLMSLNLEQYVSEFSAQNITGEQLLQL-DGNKLKALGMTASQDRAVVKKKLKEMKMS 1051
L + + + Q E +L D K +AL A + ++ LK++++
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK---LEGDLKDLELQ 1639
Query: 1052 LEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMTSTTAE 1093
+ A K +E+ KQ KL Q QM+ ++ E ++ E
Sbjct: 1640 ADSAIKGREEAIKQLRKL----QAQMKDFQRELEDARASRDE 1677
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 62.0 bits (149), Expect = 3e-09
Identities = 96/440 (21%), Positives = 187/440 (42%), Gaps = 77/440 (17%)
Query: 658 ELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQ 717
E+ ED ++ K ++ KEL+ KH+ E L+ +LQA +T+
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA-----------ETE 901
Query: 718 LQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQK 777
L EE + R+ + E + + H + L+E + + Q L+ + K + + D +++
Sbjct: 902 LYAEAEEMRVRLAAKKQ---ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 778 ELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFER 837
++ +EA R+K++ LEK + +I+ LE E+ + QN +++ + E
Sbjct: 959 ----LEEEEAARQKLQ-LEKV------TAEAKIKKLEDEILVMDDQN-NKLSKERKLLEE 1006
Query: 838 RTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQR 897
R S D NL ++ E +L +K ++L V+ +++
Sbjct: 1007 RIS-------DLTTNLAEEE------------EKAKNLTKLKNKHESMISELEVRLKKEE 1047
Query: 898 PSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSS 957
SR L + L+RK D S ADL AE L LA
Sbjct: 1048 KSRQEL----------EKLKRK---LEGDASDFHEQIADLQAQIAE-----LKMQLAKKE 1089
Query: 958 DE---SLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNI 1014
+E +L +DDEI + K++ + E + + L S + +E +++
Sbjct: 1090 EELQAALARLDDEI-----AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 1015 TGEQLLQLDGNKLKALGMTASQD--RAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRK 1072
GE+L L L TA+Q RA ++++ +K +L++ ++ E Q +++R+K
Sbjct: 1145 -GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH---EAQVQEMRQK 1200
Query: 1073 EQEQMQRKSKKTEKMTSTTA 1092
+ ++ +++ E+ A
Sbjct: 1201 HAQAVEELTEQLEQFKRAKA 1220
Score = 55.5 bits (132), Expect = 3e-07
Identities = 102/521 (19%), Positives = 210/521 (40%), Gaps = 78/521 (14%)
Query: 601 QLISQTLEQERRQRELL--EQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFE 658
QL+S +++R+ +LL E++ + AD+ + E E+E + + + A+E E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 659 ---------LPENEDMFSPSELDTSKLSHKFKE----LQIKHAVTEAEIQKLKTKLQAAE 705
E ED+ S + D K H+ ++ L+ + + ++++L+ +LQA E
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 706 NEKVRWELE--------KTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQY 757
+ K+R E+ + LQ E+N+E+ +L Q H L++ + Q
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-------QRQLHEYETELEDERKQR 1612
Query: 758 QALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEA-- 815
K + +KD + + IK +E K++ L+ +++ Q + D A
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ----AQMKDFQRELEDARASR 1668
Query: 816 -EVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPE 874
E+F K+N E++ E E+L + + + +A E
Sbjct: 1669 DEIFATAKEN-----------EKKAKSLEADLMQLQEDLAAAERARK--------QADLE 1709
Query: 875 TERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSS 934
E L A + + LS +N Q R RL ++ + E E+ N D +T
Sbjct: 1710 KEEL---AEELASSLSGRNALQDEKR-RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 935 ADL--SGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQ 992
A+ + L E T ++S + + ++ + + K A E + Q
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 993 VSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSL 1052
LE+ V + + + + L+ KLK + + +R + ++ ++ +
Sbjct: 1826 ---------LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Query: 1053 EKARKAQEKMEKQREKL------RRKEQEQMQRKSKKTEKM 1087
+ ++ + ++E+ E+ RRK Q ++ ++ E M
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 47.4 bits (111), Expect = 8e-05
Identities = 71/333 (21%), Positives = 128/333 (38%), Gaps = 48/333 (14%)
Query: 591 EKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGS 650
EK Q+ LE ER+QR L + + D + E + + G
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD--------LKDLELQADSAIKGR 1640
Query: 651 DMAIEVFELPENEDMFSPSELDTSKLSHK-----FKELQIKHAVTEAEIQKLKTKLQAAE 705
+ AI+ + + EL+ ++ S KE + K EA++ +L+ L AAE
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 706 NEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYN 765
+ + +LEK +L + + + L+ + + E L+E Q +A+ +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 766 KA--------KKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVE----------VQGLQ 807
KA +L + + + RQ+ ER+ E K H +E + L+
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 808 VRIRDLEAEV----------FRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTME-NLDGK 856
+I LE +V + LKQ ++ E + E K + N K
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 857 QTSCQDGLSQDLNEAVPETERLDSKALKTRAQL 889
Q L + L EA E++R+++ K + +L
Sbjct: 1881 Q------LKRQLEEAEEESQRINANRRKLQREL 1907
Score = 44.3 bits (103), Expect = 6e-04
Identities = 100/522 (19%), Positives = 202/522 (38%), Gaps = 57/522 (10%)
Query: 590 REKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGP--VL 647
R QV E+ Q +Q +E+ Q E + + A+ D+ + E D G VL
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLE----QFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 648 PGSDMAIE------VFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKL 701
+ +E ++ E + S E ++L+ K +LQ E++ + L
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-------NEVESVTGML 1296
Query: 702 QAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQY---- 757
AE + ++ + L +++ +E + + + T + E Q Q
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 758 ---QALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLE 814
Q LE+ + + D ++K DF EA +E+ +K E++ L + +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA----LEEGKKRFQKEIENLTQQYEEKA 1412
Query: 815 AEVFRLLK-QNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVP 873
A +L K +N Q ++ + + VS NL+ KQ + ++ +
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS------NLEKKQ--------RKFDQLLA 1458
Query: 874 ETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSV-SSTDGEDSLERKNFTFNDDFSPSST 932
E + + SK R + + R + L ++ + + ++ LER N + +
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 933 SSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQ 992
S D +G S+ + E + +E+ D+ Q+ + ++ + + Q
Sbjct: 1519 SKDD---VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 993 VSHWLMSLNLEQYVSEFSAQNITGEQLLQL-DGNKLKALGMTASQDRAVVKKKLKEMKMS 1051
L + + + Q E +L D K +AL A + ++ LK++++
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK---LEGDLKDLELQ 1632
Query: 1052 LEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMTSTTAE 1093
+ A K +E+ KQ KL Q QM+ ++ E ++ E
Sbjct: 1633 ADSAIKGREEAIKQLRKL----QAQMKDFQRELEDARASRDE 1670
>gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens]
Length = 388
Score = 60.8 bits (146), Expect = 7e-09
Identities = 72/316 (22%), Positives = 133/316 (42%), Gaps = 35/316 (11%)
Query: 680 FKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEE----NKERMLKLESY 735
+K LQ + V E + + +K ++ AENE E+ KT L Q EE ER L L S+
Sbjct: 17 YKALQEELTVKEKQEEDIKRRINLAENEL---EITKTLLNQTREEVLTLKNERELMLISH 73
Query: 736 WIEAQTLCHTVNEHLKETQSQYQALEKKYNKAK-KLIKDFQQKELDFIKRQ----EAERK 790
+ L T+ + L + + +E + K + + + +F+++ L F + + E++
Sbjct: 74 QKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKE 133
Query: 791 KIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTM 850
K +D+ + + E + LQ++I DL R L+Q T + + R + SK +
Sbjct: 134 KHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEI 193
Query: 851 ENLDG----------KQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSR 900
ENL K+ D +S++L + + + + + + QL + + +
Sbjct: 194 ENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEEN 253
Query: 901 TRLYDSVS-------------STDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTP 947
T L ++V S E LE + FSP S S L+ A
Sbjct: 254 TFLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNH 313
Query: 948 GLSQSLALSSDESLDM 963
G L+S++ + +
Sbjct: 314 GERSLARLNSEKGIQI 329
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 60.1 bits (144), Expect = 1e-08
Identities = 83/341 (24%), Positives = 131/341 (38%), Gaps = 30/341 (8%)
Query: 271 AHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKA 330
+HK + A L ++ + K+PED +S Q S P AE A
Sbjct: 785 SHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSS--QAFISTQNGSPRLNRAEVPA 842
Query: 331 MPKSEIPSPQSQLLEDAEANLVGREAAKQQRKELAGG-----DFTSPDASASSCGK-EVP 384
P + P +L+ E G + K G + A CGK +V
Sbjct: 843 RPAPQ--EPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
Query: 385 EDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGT------EQDEEEDSDENSYYQPDME 438
+ + +G + S N+ ++ D G T T E+ S NS Q
Sbjct: 901 DHISAVNGQSIVELSHDNIVQLIK----DAGVTVTLTVIAEEEHHGPPSGTNSARQSPAL 956
Query: 439 YSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVE 498
+G + IP +R V +Y + D ++ P A + +
Sbjct: 957 QHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKH-LAQPDTAVISVVGSRHNQ 1015
Query: 499 KLELFPVELEKDEDGLGISIIGMGVGADAGLE-KLGIFVKTVTEGGAAQRDGRIQVNDQI 557
L +PVELE+ G G S+ G G E +G+F+ + E G A +DGRI V DQI
Sbjct: 1016 NLGCYPVELERGPRGFGFSLRG-------GKEYNMGLFILRLAEDGPAIKDGRIHVGDQI 1068
Query: 558 VEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSE 598
VE++G G+T A +++ GN ++ R G + +
Sbjct: 1069 VEINGEPTQGITHTRAIELIQ-AGGNKVLLLLRPGTGLIPD 1108
Score = 41.2 bits (95), Expect = 0.005
Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 12/91 (13%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
V L K E G G ++G G G D I++ + GAA++DGR++ D+++ +DGI
Sbjct: 727 VFLRKQESGFGFRVLG-GDGPDQS-----IYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
Query: 565 LVGVTQ----NFAATVLRNTKGNVRFVIGRE 591
+ G + + T RN G+V + R+
Sbjct: 781 VKGKSHKQVLDLMTTAARN--GHVLLTVRRK 809
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 60.1 bits (144), Expect = 1e-08
Identities = 83/341 (24%), Positives = 131/341 (38%), Gaps = 30/341 (8%)
Query: 271 AHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKA 330
+HK + A L ++ + K+PED +S Q S P AE A
Sbjct: 785 SHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSS--QAFISTQNGSPRLNRAEVPA 842
Query: 331 MPKSEIPSPQSQLLEDAEANLVGREAAKQQRKELAGG-----DFTSPDASASSCGK-EVP 384
P + P +L+ E G + K G + A CGK +V
Sbjct: 843 RPAPQ--EPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
Query: 385 EDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGT------EQDEEEDSDENSYYQPDME 438
+ + +G + S N+ ++ D G T T E+ S NS Q
Sbjct: 901 DHISAVNGQSIVELSHDNIVQLIK----DAGVTVTLTVIAEEEHHGPPSGTNSARQSPAL 956
Query: 439 YSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVE 498
+G + IP +R V +Y + D ++ P A + +
Sbjct: 957 QHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKH-LAQPDTAVISVVGSRHNQ 1015
Query: 499 KLELFPVELEKDEDGLGISIIGMGVGADAGLE-KLGIFVKTVTEGGAAQRDGRIQVNDQI 557
L +PVELE+ G G S+ G G E +G+F+ + E G A +DGRI V DQI
Sbjct: 1016 NLGCYPVELERGPRGFGFSLRG-------GKEYNMGLFILRLAEDGPAIKDGRIHVGDQI 1068
Query: 558 VEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSE 598
VE++G G+T A +++ GN ++ R G + +
Sbjct: 1069 VEINGEPTQGITHTRAIELIQ-AGGNKVLLLLRPGTGLIPD 1108
Score = 41.2 bits (95), Expect = 0.005
Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 12/91 (13%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
V L K E G G ++G G G D I++ + GAA++DGR++ D+++ +DGI
Sbjct: 727 VFLRKQESGFGFRVLG-GDGPDQS-----IYIGAIIPLGAAEKDGRLRAADELMCIDGIP 780
Query: 565 LVGVTQ----NFAATVLRNTKGNVRFVIGRE 591
+ G + + T RN G+V + R+
Sbjct: 781 VKGKSHKQVLDLMTTAARN--GHVLLTVRRK 809
>gi|56550043 sarcolemma associated protein [Homo sapiens]
Length = 811
Score = 60.1 bits (144), Expect = 1e-08
Identities = 104/425 (24%), Positives = 190/425 (44%), Gaps = 47/425 (11%)
Query: 697 LKTKLQAAENEKVRWELE-KTQLQQNIEENKERMLKLESYWIEAQTLCHTVNE--HLKE- 752
L+ +L A + +K +E K L++ ++E E + KL ++L +T +E HLKE
Sbjct: 236 LRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEV---ERSLSNTEDECTHLKEM 292
Query: 753 ---TQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVR 809
TQ + + L KYN A IKD K +K E ++++I+ +A E + LQ +
Sbjct: 293 NERTQEELRELANKYNGAVNEIKDLSDK----LKVAEGKQEEIQQKGQA---EKKELQHK 345
Query: 810 IRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGE--VSKGDTMENLDGKQTSCQDGLSQD 867
I ++E + L + +N+ ER T+L E +SK + CQ L +
Sbjct: 346 IDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVE 405
Query: 868 --LNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFND 925
L +AV ET+ SK +TRA+ S + PS+ + S+D + N+
Sbjct: 406 GHLTKAVEETKL--SKENQTRAKESDFSDTLSPSKEK------SSDDTTDAQMDEQDLNE 457
Query: 926 DFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMID---------DEILDDGQSPK 976
+ S DL G +E + Q L E+ ++ +L++ +
Sbjct: 458 PLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAY 517
Query: 977 HSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQ-NITGEQLLQLDGNKL---KALGM 1032
+Q + + ++ V Q + ++ E E ++ T ++LL L +A
Sbjct: 518 RNQVE-ESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAK 576
Query: 1033 TASQ---DRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQR-KSKKTEKMT 1088
AS+ D A ++++LK+++ LE+ RKA + EK+ L+ Q + Q+ + ++ E+ T
Sbjct: 577 VASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEAT 636
Query: 1089 STTAE 1093
E
Sbjct: 637 RLQGE 641
Score = 34.3 bits (77), Expect = 0.66
Identities = 32/152 (21%), Positives = 68/152 (44%), Gaps = 17/152 (11%)
Query: 688 AVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIE------ENKER---------MLKL 732
A + E++K++ +L+ +E E T LQ + + E+++R + KL
Sbjct: 586 ASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKL 645
Query: 733 ESYWIEAQTLCHTVNEHLKETQSQYQALEKK-YNKAKKLIKDFQQKELDFIKRQEAERKK 791
W +T CH++ S+ Q EK+ +N K+ ++ + + R+E E +
Sbjct: 646 RKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELE-NQ 704
Query: 792 IEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQ 823
+ L++ HL + L+ + E + + K+
Sbjct: 705 VGSLKEQHLRDSADLKTLLSKAENQAKDVQKE 736
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 59.7 bits (143), Expect = 1e-08
Identities = 88/435 (20%), Positives = 192/435 (44%), Gaps = 43/435 (9%)
Query: 681 KELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEA- 739
KE++ A+ E I + K +E E++R E++ + +I +++ L E E+
Sbjct: 731 KEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESR 790
Query: 740 -QTLCHTVN---EHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDL 795
Q L + + L TQS Y++ ++++ K L DF+QK ++ E ++I +L
Sbjct: 791 VQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNL 850
Query: 796 EKAHLVEVQGLQVRIRDLEAEVF---RLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMEN 852
K E Q + L+ E+ + L++ +V N E+ E ++ T++
Sbjct: 851 SK----EAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE-NRDSTLQT 905
Query: 853 LDGKQTSCQDGLSQDLNEAVPET-ERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSST- 910
++ ++T + L Q L E T E+ D K L+ Q+ + ++ ++D+V+
Sbjct: 906 VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE-----RDQLKSDIHDTVNMNI 960
Query: 911 -------DGEDSLERKNFTFN---DDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDES 960
+ +SL++ T N S + + + E K + + + +
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 961 L----------DMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFS 1010
L D+ D+EI++ Q S Q + + ++ V L + + E
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQ-QRKIFSLIQEKNELQQMLESVIAEKEQLKTD--LKENI 1077
Query: 1011 AQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLR 1070
I ++ L+L G++LK +Q++ KK E+ + ++ + +EK++++ ++L+
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137
Query: 1071 RKEQEQMQRKSKKTE 1085
K+Q+ + + + +E
Sbjct: 1138 EKQQQLLNVQEEMSE 1152
Score = 53.9 bits (128), Expect = 8e-07
Identities = 109/523 (20%), Positives = 202/523 (38%), Gaps = 54/523 (10%)
Query: 591 EKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGS 650
EK +++ + I T+E + R L ++ Q + E E G +
Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE-----GELSRTC 1119
Query: 651 DMAIEVFE-LPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKV 709
D EV E L E + + + E+Q K EI+ LK +L+ E
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN----EIENLKNELKNKELTLE 1175
Query: 710 RWELEKTQLQQNIEENKER---MLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNK 766
E E+ +L Q + EN E + K E Q T +HL+ + +A + +
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235
Query: 767 AKKL----IKDFQQKELDFIKRQEAERK----KIEDLEKAHLVEVQGLQVRIRDLEAEVF 818
K+ +K+ Q+ +D ++R +E+ +DLEK+H + ++ + E E+
Sbjct: 1236 ELKIAHIHLKE-HQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE--EIPVLHEEQELL 1292
Query: 819 RLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERL 878
+K+ ++ N E T T+ ++ ++ + + E T+
Sbjct: 1293 PNVKE-VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKER 1351
Query: 879 DS-KALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSL---ERKNFTFNDDFSPSSTSS 934
D+ K +K ++ ++ T S + E SL E+ N T
Sbjct: 1352 DNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP 1411
Query: 935 ADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVS 994
D + L E + GLS+ L S DE + ++ DD Q +Q S Q
Sbjct: 1412 KDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK--DD------LQRLQEVLQSESDQ--- 1460
Query: 995 HWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEK 1054
L++ + E A+++ E+ L++ LK T ++ R + +K E+
Sbjct: 1461 -------LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS----- 1508
Query: 1055 ARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMTSTTAEGAGE 1097
Q+++E +KL+ K QE +++ + K S E E
Sbjct: 1509 --TIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE 1549
Score = 52.0 bits (123), Expect = 3e-06
Identities = 102/519 (19%), Positives = 213/519 (41%), Gaps = 54/519 (10%)
Query: 598 EVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVG--PVLPGSDMAIE 655
E Q++ + E+ +R +E L+ Q + E + +E E + ++ +
Sbjct: 1583 EEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEK 1642
Query: 656 VFELPENEDMFSPSELDTSKL-SHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELE 714
+ E+ ++ F +L+ + + + QI H E E++ + + + + ++E
Sbjct: 1643 MCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE-EMRSVTKERDDLRSVEETLKVE 1701
Query: 715 KTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALE----KKYNKAKKL 770
+ QL++N+ E R L E Q V+ HLKE Q L +K N+ +
Sbjct: 1702 RDQLKENLRETITRDL-------EKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754
Query: 771 IKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNN 830
KD + D +K Q+ + ++ + HL E Q ++R + +E L + N
Sbjct: 1755 QKDLEHSN-DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLEN 1813
Query: 831 NNNIFERRTSLGEVSKGDTME-----NLDGKQTSCQDGLSQDLNEAVPETERLDSKALKT 885
+N + + + ++ + N K+ S + L + + + +L+ + L
Sbjct: 1814 SNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL 1873
Query: 886 RAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPK 945
+L +N + S + D++ + LER S T + DL + E K
Sbjct: 1874 AQKLH-ENLEEMKSVMKERDNLRRVEETLKLERDQLKE----SLQETKARDLE-IQQELK 1927
Query: 946 TPGLSQSLALSSDESLDMIDDEILD----------------DGQSPKHSQCQNRAVQEWS 989
T ++ L+ E++D + ++I + D K + Q + +Q
Sbjct: 1928 T---ARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLR 1984
Query: 990 VQQ---VSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKK-- 1044
V++ +SH ++ +EQ +F AQN++ + + + K L + + R V K++
Sbjct: 1985 VKEDVNMSHKKIN-EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDE 2043
Query: 1045 LKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKK 1083
L+ +K SL+ R + + RE + R Q + K+
Sbjct: 2044 LRRIKESLKMER--DQFIATLREMIARDRQNHQVKPEKR 2080
Score = 39.3 bits (90), Expect = 0.021
Identities = 103/538 (19%), Positives = 225/538 (41%), Gaps = 51/538 (9%)
Query: 587 VIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPV 646
V ++ ++S +L+ + +Q ++ +E ++ + D + ++ + +
Sbjct: 568 VYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627
Query: 647 LPGSDMAIEVFELPENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAEN 706
+A++ + E F SE +L K KEL + E +IQ +++L+A
Sbjct: 628 FDAETVALDA----KRESAFLRSE--NLELKEKMKELATTYKQMENDIQLYQSQLEA--K 679
Query: 707 EKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNK 766
+K++ +LEK +LQ E ++ L + LC+ E + + L+K+ NK
Sbjct: 680 KKMQVDLEK-ELQSAFNE-ITKLTSLIDGKVPKDLLCNL------ELEGKITDLQKELNK 731
Query: 767 AKKLIKDFQQK-----ELDFIKRQ-EAERKKIED-LEKAHLV--EVQGLQVRIRDLEAEV 817
+ + +++ EL + + E RK+I+D E+ H++ E L + E+ V
Sbjct: 732 EVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRV 791
Query: 818 FRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQ-----TSCQDGLSQDLNEAV 872
LL++ G ++ S + + ++D +Q + ++Q++
Sbjct: 792 QGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS 851
Query: 873 PETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDG-EDSLERKNFTFNDDFSPSS 931
E ++ DS + +LS K + + + + ++ + ++ LE ++ T +
Sbjct: 852 KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT 911
Query: 932 TSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHSQCQNRAVQEWSVQ 991
+ L E KT + ESL + D++ D + + +++
Sbjct: 912 LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 992 QVSHWLMSLN-LEQYVSEFSAQNI-----TGEQLLQLDGNKLKALGMTASQD-----RAV 1040
+ ++N L+ +SE ++N+ TGE D + K +G+ QD
Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGE---TKDEFQQKMVGIDKKQDLEAKNTQT 1028
Query: 1041 VKKKLKEMKMSLEKARK----AQEKME-KQREKLRRKEQEQMQRKSKKTEKMTSTTAE 1093
+ +K+ ++ +E+ RK QEK E +Q + E+EQ++ K+ +MT E
Sbjct: 1029 LTADVKDNEI-IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQE 1085
Score = 38.5 bits (88), Expect = 0.035
Identities = 31/137 (22%), Positives = 66/137 (48%), Gaps = 13/137 (9%)
Query: 689 VTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNE 748
+T +I++L+ L A+ + E + ++Q+ +E + + KL Q H N+
Sbjct: 2378 LTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL-------QAKVHESNK 2430
Query: 749 HLKETQSQYQALEKKYN-KAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQ 807
L++T+ Q L+ K AK ++ + ++ +K + K ++ EK E+ +
Sbjct: 2431 CLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEK----EISATK 2486
Query: 808 VRIRDLEAEVFRLLKQN 824
+ + + EV RLL++N
Sbjct: 2487 ATV-EYQKEVIRLLREN 2502
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/86 (40%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
++L K GLG SI G GVG I+V + +GGAAQ+DGR+QV D+++ V+ S
Sbjct: 143 IKLFKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 201
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGR 590
L VT A +L+NT V +G+
Sbjct: 202 LEEVTHEEAVAILKNTSEVVYLKVGK 227
Score = 55.8 bits (133), Expect = 2e-07
Identities = 35/104 (33%), Positives = 52/104 (50%), Gaps = 10/104 (9%)
Query: 490 EYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDG 549
EYE E+ + LE+ GLG SI G G + GIF+ + GGAA DG
Sbjct: 42 EYEFEE---------ITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDG 91
Query: 550 RIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKP 593
R++VND I+ V+ + + V+ + A L+ VR + R +P
Sbjct: 92 RLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP 135
Score = 50.4 bits (119), Expect = 9e-06
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 8/105 (7%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
V L K GLG +I+G G + GIFV + GG A G +Q DQI+ V+GI
Sbjct: 319 VVLHKGSTGLGFNIVG-------GEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQ 609
L G + AA L+ G +I + +P + I EQ
Sbjct: 372 LRGASHEQAAAALKGA-GQTVTIIAQYQPEDYARFEAKIHDLREQ 415
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/86 (40%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
++L K GLG SI G GVG I+V + +GGAAQ+DGR+QV D+++ V+ S
Sbjct: 299 IKLFKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 357
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGR 590
L VT A +L+NT V +G+
Sbjct: 358 LEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 56.6 bits (135), Expect = 1e-07
Identities = 43/137 (31%), Positives = 65/137 (47%), Gaps = 17/137 (12%)
Query: 457 IKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGI 516
+K S API + NT D +D + E+E E+ + LE+ GLG
Sbjct: 172 LKASPAPI-IVNT----------DTLDTIPYVNGTEIEYEFEE-----ITLERGNSGLGF 215
Query: 517 SIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATV 576
SI G G + GIF+ + GGAA DGR++VND I+ V+ + + V+ + A
Sbjct: 216 SIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEA 274
Query: 577 LRNTKGNVRFVIGREKP 593
L+ VR + R +P
Sbjct: 275 LKEAGSIVRLYVRRRRP 291
Score = 50.4 bits (119), Expect = 9e-06
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 8/105 (7%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
V L K GLG +I+G G + GIFV + GG A G +Q DQI+ V+GI
Sbjct: 527 VVLHKGSTGLGFNIVG-------GEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 579
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQ 609
L G + AA L+ G +I + +P + I EQ
Sbjct: 580 LRGASHEQAAAALKGA-GQTVTIIAQYQPEDYARFEAKIHDLREQ 623
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/86 (40%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
++L K GLG SI G GVG I+V + +GGAAQ+DGR+QV D+++ V+ S
Sbjct: 194 IKLFKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 252
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGR 590
L VT A +L+NT V +G+
Sbjct: 253 LEEVTHEEAVAILKNTSEVVYLKVGK 278
Score = 56.6 bits (135), Expect = 1e-07
Identities = 43/137 (31%), Positives = 65/137 (47%), Gaps = 17/137 (12%)
Query: 457 IKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGI 516
+K S API + NT D +D + E+E E+ + LE+ GLG
Sbjct: 67 LKASPAPI-IVNT----------DTLDTIPYVNGTEIEYEFEE-----ITLERGNSGLGF 110
Query: 517 SIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATV 576
SI G G + GIF+ + GGAA DGR++VND I+ V+ + + V+ + A
Sbjct: 111 SIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEA 169
Query: 577 LRNTKGNVRFVIGREKP 593
L+ VR + R +P
Sbjct: 170 LKEAGSIVRLYVRRRRP 186
Score = 50.4 bits (119), Expect = 9e-06
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 8/105 (7%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
V L K GLG +I+G G + GIFV + GG A G +Q DQI+ V+GI
Sbjct: 422 VVLHKGSTGLGFNIVG-------GEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 474
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQ 609
L G + AA L+ G +I + +P + I EQ
Sbjct: 475 LRGASHEQAAAALKGA-GQTVTIIAQYQPEDYARFEAKIHDLREQ 518
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 59.7 bits (143), Expect = 1e-08
Identities = 33/79 (41%), Positives = 54/79 (68%), Gaps = 5/79 (6%)
Query: 513 GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNF 572
GLG+S+ G + G + LGIF+K++ GGAA +DGR+++NDQ++ V+G SL+G + +
Sbjct: 508 GLGVSLKG-NKSRETGTD-LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
Query: 573 AATVLRNT---KGNVRFVI 588
A LR + +GN+R +I
Sbjct: 566 AMETLRRSMSMEGNIRGMI 584
Score = 53.9 bits (128), Expect = 8e-07
Identities = 31/78 (39%), Positives = 48/78 (61%), Gaps = 5/78 (6%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLG-IFVKTVTEGGAAQRDGRIQVNDQIVEVDGI 563
++L+K +GLG ++ V D+ + G IFVK + GAA +DGR+Q D+I+EV+G
Sbjct: 384 IDLKKGPEGLGFTV----VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
Query: 564 SLVGVTQNFAATVLRNTK 581
+ G TQ +LR+TK
Sbjct: 440 DVTGRTQEELVAMLRSTK 457
Score = 33.1 bits (74), Expect = 1.5
Identities = 15/43 (34%), Positives = 28/43 (65%)
Query: 1041 VKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKK 1083
++ K +++K + EK +K ++ K +EK R++E E +RK KK
Sbjct: 827 MENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKK 869
Score = 32.7 bits (73), Expect = 1.9
Identities = 19/74 (25%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
VE+ + LGI ++ + LG+F++ + + ++R+G N+ IV+++ +
Sbjct: 204 VEISGEGGPLGIHVVPFFSSLSGRI--LGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261
Query: 565 LVGVTQNFAATVLR 578
LV T A V R
Sbjct: 262 LVDKTFAQAQDVFR 275
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 59.7 bits (143), Expect = 1e-08
Identities = 33/79 (41%), Positives = 54/79 (68%), Gaps = 5/79 (6%)
Query: 513 GLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNF 572
GLG+S+ G + G + LGIF+K++ GGAA +DGR+++NDQ++ V+G SL+G + +
Sbjct: 508 GLGVSLKG-NKSRETGTD-LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
Query: 573 AATVLRNT---KGNVRFVI 588
A LR + +GN+R +I
Sbjct: 566 AMETLRRSMSMEGNIRGMI 584
Score = 53.9 bits (128), Expect = 8e-07
Identities = 31/78 (39%), Positives = 48/78 (61%), Gaps = 5/78 (6%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLG-IFVKTVTEGGAAQRDGRIQVNDQIVEVDGI 563
++L+K +GLG ++ V D+ + G IFVK + GAA +DGR+Q D+I+EV+G
Sbjct: 384 IDLKKGPEGLGFTV----VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
Query: 564 SLVGVTQNFAATVLRNTK 581
+ G TQ +LR+TK
Sbjct: 440 DVTGRTQEELVAMLRSTK 457
Score = 33.1 bits (74), Expect = 1.5
Identities = 15/43 (34%), Positives = 28/43 (65%)
Query: 1041 VKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKK 1083
++ K +++K + EK +K ++ K +EK R++E E +RK KK
Sbjct: 758 MENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKK 800
Score = 32.7 bits (73), Expect = 1.9
Identities = 19/74 (25%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
VE+ + LGI ++ + LG+F++ + + ++R+G N+ IV+++ +
Sbjct: 204 VEISGEGGPLGIHVVPFFSSLSGRI--LGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261
Query: 565 LVGVTQNFAATVLR 578
LV T A V R
Sbjct: 262 LVDKTFAQAQDVFR 275
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 59.3 bits (142), Expect = 2e-08
Identities = 85/361 (23%), Positives = 149/361 (41%), Gaps = 59/361 (16%)
Query: 271 AHKSNATPVPEVASKSTSLASIP---------GEEIQQSKEPEDSTSNQQTPDSIDK--D 319
A SNA+P AS S + + G I S +S S P I + D
Sbjct: 900 APSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIID 959
Query: 320 G-PEEPCAESKAMPKSEIPSPQS----------QLLEDAEANLVGREAAKQQRKE---LA 365
G P + CA+ K + + QS +L++DA ++ R +++
Sbjct: 960 GSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAP 1019
Query: 366 GGDFTSPDASASSCGKEVP--EDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDE 423
+ SP A S ++ P + S S + + +++ NS E QD
Sbjct: 1020 SSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDV 1079
Query: 424 EEDSDE---NSYYQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRND 480
+ D + Y QP ++Y + G ++ P + + P+ + +S +
Sbjct: 1080 KPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPP----LDYRQPPLLDYRQHSPD------- 1128
Query: 481 EVDPVAASAEYELE--KRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLE-KLGIFVK 537
+ +Y L ++ + + F V++EK G G SI G G E K+ ++V
Sbjct: 1129 -------TRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRG-------GREYKMDLYVL 1174
Query: 538 TVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVS 597
+ E G A R+GR++V DQI+E++G S +T A ++++ VR ++ R GQV
Sbjct: 1175 RLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKR-GTGQVP 1233
Query: 598 E 598
E
Sbjct: 1234 E 1234
Score = 43.9 bits (102), Expect = 8e-04
Identities = 28/89 (31%), Positives = 43/89 (48%), Gaps = 8/89 (8%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
V L + E G G I+G G + G I + V G+A RDGR+ D++V VDGI
Sbjct: 779 VHLRRMESGFGFRILG---GDEPGQP---ILIGAVIAMGSADRDGRLHPGDELVYVDGIP 832
Query: 565 LVGVTQNFAATVLRNT--KGNVRFVIGRE 591
+ G T + ++ + G V + R+
Sbjct: 833 VAGKTHRYVIDLMHHAARNGQVNLTVRRK 861
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 58.2 bits (139), Expect = 4e-08
Identities = 47/167 (28%), Positives = 76/167 (45%), Gaps = 19/167 (11%)
Query: 432 YYQPDMEYSEIVGLPEE-----EEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVA 486
YY+ + S+ +E E PA+ + +S P+ + NT + E A
Sbjct: 44 YYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPV-IVNTDTLE------------A 90
Query: 487 ASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQ 546
E ++ ++E + LE+ GLG SI G G + IF+ + GGAA
Sbjct: 91 PGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIG-DDPSIFITKIIPGGAAA 149
Query: 547 RDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKP 593
+DGR++VND I+ V+ + + VT + A L+ VR + R KP
Sbjct: 150 QDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP 196
Score = 57.4 bits (137), Expect = 7e-08
Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 7/137 (5%)
Query: 491 YELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGR 550
Y + ++ ++ ++L K GLG SI G GVG I+V + EGGAA +DGR
Sbjct: 190 YVMRRKPPAEKVMEIKLIKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIEGGAAHKDGR 248
Query: 551 IQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVS------EVAQLIS 604
+Q+ D+I+ V+ + L V A L+NT V + + +S ++ S
Sbjct: 249 LQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYS 308
Query: 605 QTLEQERRQRELLEQHY 621
Q L+ E L Y
Sbjct: 309 QHLDNEISHSSYLGTDY 325
Score = 49.3 bits (116), Expect = 2e-05
Identities = 31/105 (29%), Positives = 49/105 (46%), Gaps = 8/105 (7%)
Query: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
+ + + GLG +I+G G + GIF+ + GG A G ++ DQI+ V+G+
Sbjct: 357 IVIHRGSTGLGFNIVG-------GEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVD 409
Query: 565 LVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQ 609
L + AA L+N G +I + KP + S I EQ
Sbjct: 410 LRNASHEQAAIALKNA-GQTVTIIAQYKPEEYSRFEAKIHDLREQ 453
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,074,739
Number of Sequences: 37866
Number of extensions: 1979333
Number of successful extensions: 17489
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 385
Number of HSP's successfully gapped in prelim test: 923
Number of HSP's that attempted gapping in prelim test: 9951
Number of HSP's gapped (non-prelim): 6603
length of query: 1098
length of database: 18,247,518
effective HSP length: 113
effective length of query: 985
effective length of database: 13,968,660
effective search space: 13759130100
effective search space used: 13759130100
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.