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Search of human proteins with 91199538
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
(870 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 1754 0.0
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 1723 0.0
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 1342 0.0
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 1197 0.0
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 1150 0.0
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 1004 0.0
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 974 0.0
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 964 0.0
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 739 0.0
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 628 e-180
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 214 4e-55
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 198 2e-50
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 182 2e-45
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 178 2e-44
gi|95089461 discs large homolog 5 [Homo sapiens] 172 9e-43
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 169 1e-41
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 167 3e-41
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 158 2e-38
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 156 7e-38
gi|10092691 tight junction protein 3 [Homo sapiens] 156 9e-38
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 152 1e-36
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 152 1e-36
gi|45827729 scribble isoform b [Homo sapiens] 145 2e-34
gi|45827731 scribble isoform a [Homo sapiens] 145 2e-34
gi|148746189 multiple PDZ domain protein [Homo sapiens] 139 1e-32
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 138 3e-32
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 138 3e-32
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 137 4e-32
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 137 4e-32
gi|112382257 InaD-like [Homo sapiens] 120 7e-27
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 1754 bits (4542), Expect = 0.0
Identities = 870/870 (100%), Positives = 870/870 (100%)
Query: 1 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL 60
MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
Sbjct: 1 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL 60
Query: 61 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH 120
QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
Sbjct: 61 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH 120
Query: 121 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY 180
IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
Sbjct: 121 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY 180
Query: 181 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ 240
VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
Sbjct: 181 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ 240
Query: 241 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP 300
VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
Sbjct: 241 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP 300
Query: 301 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS 360
MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
Sbjct: 301 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS 360
Query: 361 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR 420
PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
Sbjct: 361 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR 420
Query: 421 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 480
KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
Sbjct: 421 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 480
Query: 481 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY 540
EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
Sbjct: 481 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY 540
Query: 541 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR 600
VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
Sbjct: 541 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR 600
Query: 601 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER 660
RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER
Sbjct: 601 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER 660
Query: 661 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE 720
GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
Sbjct: 661 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE 720
Query: 721 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA 780
VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA
Sbjct: 721 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA 780
Query: 781 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG 840
IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG
Sbjct: 781 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG 840
Query: 841 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 870
DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Sbjct: 841 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 870
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 1723 bits (4463), Expect = 0.0
Identities = 856/856 (100%), Positives = 856/856 (100%)
Query: 15 KYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPI 74
KYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPI
Sbjct: 120 KYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPI 179
Query: 75 IVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 134
IVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIP
Sbjct: 180 IVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 239
Query: 135 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 194
GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI
Sbjct: 240 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 299
Query: 195 KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 254
KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE
Sbjct: 300 KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 359
Query: 255 EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLE 314
EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLE
Sbjct: 360 EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLE 419
Query: 315 YKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFL 374
YKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFL
Sbjct: 420 YKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFL 479
Query: 375 LSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFN 434
LSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFN
Sbjct: 480 LSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFN 539
Query: 435 IVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 494
IVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV
Sbjct: 540 IVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 599
Query: 495 TIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSG 554
TIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSG
Sbjct: 600 TIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSG 659
Query: 555 LPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVK 614
LPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVK
Sbjct: 660 LPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVK 719
Query: 615 FNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTR 674
FNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTR
Sbjct: 720 FNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTR 779
Query: 675 QEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQ 734
QEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQ
Sbjct: 780 QEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQ 839
Query: 735 MEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAI 794
MEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAI
Sbjct: 840 MEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAI 899
Query: 795 FIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVI 854
FIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVI
Sbjct: 900 FIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVI 959
Query: 855 EEQSGPFIWIPSKEKL 870
EEQSGPFIWIPSKEKL
Sbjct: 960 EEQSGPFIWIPSKEKL 975
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 1342 bits (3472), Expect = 0.0
Identities = 693/784 (88%), Positives = 698/784 (89%), Gaps = 70/784 (8%)
Query: 87 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 146
VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV
Sbjct: 36 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
Query: 147 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 206
NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS
Sbjct: 96 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
Query: 207 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 266
IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK
Sbjct: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
Query: 267 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 326
NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR
Sbjct: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
Query: 327 YSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGL 386
YSPI P+H +
Sbjct: 276 YSPI------------------------------PKH----------------------M 283
Query: 387 LPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV 446
L D + TSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV
Sbjct: 284 LVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV 343
Query: 447 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA 506
SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA
Sbjct: 344 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA 403
Query: 507 RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 566
RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD
Sbjct: 404 RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 463
Query: 567 ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG 626
ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG
Sbjct: 464 ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG 523
Query: 627 SFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIIL 686
+ + RGQEDLILSYEPVTRQEINYTRPVIIL
Sbjct: 524 DIPGLGDDGY------------------GTKTLRGQEDLILSYEPVTRQEINYTRPVIIL 565
Query: 687 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 746
GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE
Sbjct: 566 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 625
Query: 747 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 806
AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME
Sbjct: 626 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 685
Query: 807 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 866
MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS
Sbjct: 686 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
Query: 867 KEKL 870
KEKL
Sbjct: 746 KEKL 749
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 1197 bits (3096), Expect = 0.0
Identities = 622/911 (68%), Positives = 711/911 (78%), Gaps = 132/911 (14%)
Query: 8 ALRTNVKKYRYQDEDAP-HDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISP 66
+L +V+KYRYQDED P +H P++T+EV GPELVHVSEKNLS+IENVHG+V SHISP
Sbjct: 100 SLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISP 159
Query: 67 LK---------------------------------ASPAPIIVNTDTLDTIPYVNGTEIE 93
+K A+P P++VNTD+L+T YVNGT+ +
Sbjct: 160 IKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDAD 219
Query: 94 YEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRV 153
YE+EEITLERGNSGLGFSIAGGTDNPHIGDD IFITKII GGAAA+DGRLRVNDCILRV
Sbjct: 220 YEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRV 279
Query: 154 NEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGN 213
NEVDV +V+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFSIAGGVGN
Sbjct: 280 NEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGN 339
Query: 214 QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVY 273
QHIPGDNSIYVTKII+GGAA KDG+LQ+GD+LL VNN LEEVTHEEAV LKNTS+ VY
Sbjct: 340 QHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVY 399
Query: 274 LKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKH 333
LKV KPT++YM D Y PPDIT+S S P++NH +SP +
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNH-----------------VSPSSF------ 436
Query: 334 MLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMT 393
L PASP YSPV +L D E+T
Sbjct: 437 --------------------LGQTPASPARYSPVS---------------KAVLGDDEIT 461
Query: 394 SHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGG 453
EPRKVVLH+GSTGLGFNIVGGEDGEGIF+SFILAGG
Sbjct: 462 R-----------------------EPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGG 498
Query: 454 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 513
PADLSGEL++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+AQY+PE+Y+RFEAKIH
Sbjct: 499 PADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIH 558
Query: 514 DLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA 573
DLREQMMN S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQGL+FK+GDILHVINA
Sbjct: 559 DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA 618
Query: 574 SDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRK 633
SDDEWWQAR+V +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K D SFNDKRK
Sbjct: 619 SDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTR--DKGQSFNDKRK 676
Query: 634 KSFIFSRKFPFYKNKEQSEQETSDPE--------------RGQEDLILSYEPVTRQEINY 679
K+ +FSRKFPFYKNK+QSEQETSD + RGQE+ +LSYEPV +QE+NY
Sbjct: 677 KN-LFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNY 735
Query: 680 TRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDI 739
TRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFV SREQMEKDI
Sbjct: 736 TRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDI 795
Query: 740 QEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR 799
QEHKFIEAGQYN++LYGTSVQSVR VAE+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+
Sbjct: 796 QEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPK 855
Query: 800 SLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSG 859
S+E +MEMNKRLTEEQA+KT++RA+KLEQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG
Sbjct: 856 SMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSG 915
Query: 860 PFIWIPSKEKL 870
+IW+P+KEKL
Sbjct: 916 SYIWVPAKEKL 926
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 1150 bits (2975), Expect = 0.0
Identities = 598/897 (66%), Positives = 688/897 (76%), Gaps = 126/897 (14%)
Query: 8 ALRTNVKKYRYQDEDAP-HDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISP 66
+L +V+KYRYQDED P +H P++T+EV GPELVHVSEKNLS+IENVHG+V SHISP
Sbjct: 100 SLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISP 159
Query: 67 LK---------------------------------ASPAPIIVNTDTLDTIPYVNGTEIE 93
+K A+P P++VNTD+L+T YVNGT+ +
Sbjct: 160 IKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDAD 219
Query: 94 YEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRV 153
YE+EEITLERGNSGLGFSIAGGTDNPHIGDD IFITKII GGAAA+DGRLRVNDCILRV
Sbjct: 220 YEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRV 279
Query: 154 NEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGN 213
NEVDV +V+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFSIAGGVGN
Sbjct: 280 NEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGN 339
Query: 214 QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVY 273
QHIPGDNSIYVTKII+GGAA KDG+LQ+GD+LL VNN LEEVTHEEAV LKNTS+ VY
Sbjct: 340 QHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVY 399
Query: 274 LKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKH 333
LKV KPT++YM D Y PPDIT+S S P++NH +SP +
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNH-----------------VSPSSF------ 436
Query: 334 MLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMT 393
L PASP YSPV +L D E+T
Sbjct: 437 --------------------LGQTPASPARYSPVS---------------KAVLGDDEIT 461
Query: 394 SHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGG 453
EPRKVVLH+GSTGLGFNIVGGEDGEGIF+SFILAGG
Sbjct: 462 R-----------------------EPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGG 498
Query: 454 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 513
PADLSGEL++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+AQY+PE+Y+RFEAKIH
Sbjct: 499 PADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIH 558
Query: 514 DLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA 573
DLREQMMN S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQGL+FK+GDILHVINA
Sbjct: 559 DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA 618
Query: 574 SDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRK 633
SDDEWWQAR+V +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K KG D
Sbjct: 619 SDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTR---DKGEIPDDMG 675
Query: 634 KSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRI 693
+ K+ + ++ RGQE+ +LSYEPV +QE+NYTRPVIILGPMKDRI
Sbjct: 676 SKGL--------KHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRI 727
Query: 694 NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDN 753
NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFV SREQMEKDIQEHKFIEAGQYN++
Sbjct: 728 NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNH 787
Query: 754 LYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTE 813
LYGTSVQSVR VAE+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+S+E +MEMNKRLTE
Sbjct: 788 LYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTE 847
Query: 814 EQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 870
EQA+KT++RA+KLEQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG +IW+P+KEKL
Sbjct: 848 EQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 1004 bits (2596), Expect = 0.0
Identities = 519/793 (65%), Positives = 611/793 (77%), Gaps = 94/793 (11%)
Query: 82 DTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED 141
D VNG++ +++EEI LERGNSGLGFSIAGG DNPH+ DDPGIFITKIIPGGAAA D
Sbjct: 115 DWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD 174
Query: 142 GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK 201
GRL VNDC+LRVNEVDVSEV HS+AVEALKEAG +VRL VRRR+P ET++E+ L KGPK
Sbjct: 175 GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK 234
Query: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261
GLGFSIAGG+GNQHIPGDNSIY+TKII+GGAAQKDGRLQ+GDRLL VNN +L++V HEEA
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294
Query: 262 VAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN----GTLEYKT 317
VA LKNTS++VYLKV KP ++++ D Y PPD +++ +NH+ ++ G +E K
Sbjct: 295 VASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKV 354
Query: 318 SLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSA 377
S Y PP+ P YSP+
Sbjct: 355 S---------------------YPAPPQ-------------VPPTRYSPIPRH------- 373
Query: 378 PYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVG 437
+L + + T EPRK++LHKGSTGLGFNIVG
Sbjct: 374 --------MLAEEDFTR-----------------------EPRKIILHKGSTGLGFNIVG 402
Query: 438 GEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 497
GEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR A+HEQAAAALK AGQ+VTI+
Sbjct: 403 GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
Query: 498 AQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPS 557
AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KRSLYVRA+FDYD+++DS LPS
Sbjct: 463 AQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPS 522
Query: 558 QGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNA 617
QGLSF YGDILHVINASDDEWWQAR V G+SE++GVIPSK+RVE+KERARLKTVKF+A
Sbjct: 523 QGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA 582
Query: 618 KPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEI 677
+ G+I+S +R FP + + +GQED ILSYEPVTRQEI
Sbjct: 583 RTGMIES--------------NRDFPGLSDDYYGAKNL----KGQEDAILSYEPVTRQEI 624
Query: 678 NYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 737
+Y RPVIILGPMKDR+NDDLISEFP KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEK
Sbjct: 625 HYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 684
Query: 738 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 797
DIQ++KFIEAGQ+NDNLYGTS+QSVR VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIK
Sbjct: 685 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 744
Query: 798 PRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQ 857
P+S+E LMEMN+R T EQA K YD+A+KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+Q
Sbjct: 745 PKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQ 804
Query: 858 SGPFIWIPSKEKL 870
SG +IW+PS EKL
Sbjct: 805 SGHYIWVPSPEKL 817
Score = 70.9 bits (172), Expect = 5e-12
Identities = 57/192 (29%), Positives = 89/192 (46%), Gaps = 22/192 (11%)
Query: 43 HVSEKN----LSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEE 98
H+S + L +E+ Y + P + SP P + + + E +
Sbjct: 337 HISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEE----------DFTREPRK 386
Query: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
I L +G++GLGF+I GG D GIF++ I+ GG A G LR D IL VN V++
Sbjct: 387 IILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
Query: 159 SEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIP 217
+H +A ALK AG V + V + RP + E K+ + + S++ G G+
Sbjct: 441 RNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTS 499
Query: 218 GDNSIYVTKIID 229
S+YV + D
Sbjct: 500 EKRSLYVRALFD 511
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 974 bits (2517), Expect = 0.0
Identities = 511/867 (58%), Positives = 611/867 (70%), Gaps = 149/867 (17%)
Query: 5 CYCALRTNVKKYRYQDEDAPH-DHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSH 63
C C + T KKYRYQDED P +HS L ++ P
Sbjct: 3 CLCIVTT--KKYRYQDEDTPPLEHSPAHLPNQANSP------------------------ 36
Query: 64 ISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGD 123
P+IVNTDTL+ YVNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGD
Sbjct: 37 ---------PVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGD 87
Query: 124 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183
DP IFITKIIPGGAAA+DGRLRVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV R
Sbjct: 88 DPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMR 147
Query: 184 RRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGD 243
R+P E V+EIKL KGPKGLGFSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD
Sbjct: 148 RKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGD 207
Query: 244 RLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMEN 303
++L VN+ LE+V HE+AVA LKNT +VVYLKV KP+ Y++D Y PPDIT SYS ++N
Sbjct: 208 KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDN 267
Query: 304 HLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRH 363
+ + +Y T++ P SPR
Sbjct: 268 EISHSSYLGTDYPTAMTP-------------------------------------TSPRR 290
Query: 364 YSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVV 423
YSPV D LL + ++ EPR++V
Sbjct: 291 YSPVAKD---------------LLGEEDIPR-----------------------EPRRIV 312
Query: 424 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQA 483
+H+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQA
Sbjct: 313 IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 372
Query: 484 AAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRA 543
A ALK AGQTVTIIAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+RA
Sbjct: 373 AIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRA 432
Query: 544 MFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVE 603
+FDYDK+KD G SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRRVE
Sbjct: 433 LFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVE 492
Query: 604 RKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQE 663
R+E +RLK + + G +G+E
Sbjct: 493 RREWSRLKAKDWGSSSG--------------------------------------SQGRE 514
Query: 664 DLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDG 723
D +LSYE VT+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DG
Sbjct: 515 DSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDG 574
Query: 724 RDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKR 783
RDYHFV SRE+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDVS NA++R
Sbjct: 575 RDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRR 634
Query: 784 LQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTL 843
LQ A L+PIAIFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+AIV+GD+
Sbjct: 635 LQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSF 694
Query: 844 EDIYNQCKLVIEEQSGPFIWIPSKEKL 870
E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 695 EEIYHKVKRVIEDLSGPYIWVPARERL 721
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 964 bits (2493), Expect = 0.0
Identities = 509/869 (58%), Positives = 610/869 (70%), Gaps = 150/869 (17%)
Query: 6 YCALRTNVKKYRYQDEDAPH-DHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHI 64
Y A + +KYRYQDED P +HS L ++ P
Sbjct: 45 YEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSP------------------------- 79
Query: 65 SPLKASPAPIIVNTDTLDTIPY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHI 121
P+IVNTDTL+ Y VNGTE E E+EEITLERGNSGLGFSIAGGTDNPHI
Sbjct: 80 --------PVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHI 131
Query: 122 GDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 181
GDDP IFITKIIPGGAAA+DGRLRVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV
Sbjct: 132 GDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYV 191
Query: 182 RRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 241
RR+P E V+EIKL KGPKGLGFSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+
Sbjct: 192 MRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQI 251
Query: 242 GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPM 301
GD++L VN+ LE+V HE+AVA LKNT +VVYLKV KP+ Y++D Y PPDIT SYS +
Sbjct: 252 GDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHL 311
Query: 302 ENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASP 361
+N + + +Y T++ P SP
Sbjct: 312 DNEISHSSYLGTDYPTAMTP-------------------------------------TSP 334
Query: 362 RHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK 421
R YSPV D LL + ++ EPR+
Sbjct: 335 RRYSPVAKD---------------LLGEEDIPR-----------------------EPRR 356
Query: 422 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
+V+H+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHE
Sbjct: 357 IVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHE 416
Query: 482 QAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYV 541
QAA ALK AGQTVTIIAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+
Sbjct: 417 QAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYI 476
Query: 542 RAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRR 601
RA+FDYDK+KD G SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRR
Sbjct: 477 RALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRR 536
Query: 602 VERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERG 661
VER+E +RLK + + G +G
Sbjct: 537 VERREWSRLKAKDWGSSSG--------------------------------------SQG 558
Query: 662 QEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEV 721
+ED +LSYE VT+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+
Sbjct: 559 REDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEI 618
Query: 722 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 781
DGRDYHFV SRE+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDVS NA+
Sbjct: 619 DGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAV 678
Query: 782 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD 841
+RLQ A L+PIAIFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+AIV+GD
Sbjct: 679 RRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGD 738
Query: 842 TLEDIYNQCKLVIEEQSGPFIWIPSKEKL 870
+ E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 739 SFEEIYHKVKRVIEDLSGPYIWVPARERL 767
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 739 bits (1907), Expect = 0.0
Identities = 366/467 (78%), Positives = 417/467 (89%), Gaps = 14/467 (2%)
Query: 418 EPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 477
EPRK++LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR
Sbjct: 46 EPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105
Query: 478 ASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKR 537
A+HEQAAAALK AGQ+VTI+AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KR
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKR 165
Query: 538 SLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 597
SLYVRA+FDYD+++DS LPSQGLSF YGDILHVINASDDEWWQAR V G+SE++GVIP
Sbjct: 166 SLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIP 225
Query: 598 SKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQE--- 654
SK+RVE+KERARLKTVKF+A+ G+I+S S KRKKSF SRKFPFYK+KE QE
Sbjct: 226 SKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSI 285
Query: 655 --------TSDPE---RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPD 703
TSD E +GQED ILSYEPVTRQEI+Y RPVIILGPMKDR+NDDLISEFP
Sbjct: 286 QEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPH 345
Query: 704 KFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVR 763
KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEKDIQ++KFIEAGQ+NDNLYGTS+QSVR
Sbjct: 346 KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVR 405
Query: 764 FVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRA 823
VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIKP+S+E LMEMN+R T EQA K YD+A
Sbjct: 406 AVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKA 465
Query: 824 IKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 870
+KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+QSG +IW+PS EKL
Sbjct: 466 MKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 512
Score = 68.6 bits (166), Expect = 2e-11
Identities = 48/136 (35%), Positives = 71/136 (52%), Gaps = 8/136 (5%)
Query: 95 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154
E +I L +G++GLGF+I GG D GIF++ I+ GG A G LR D IL VN
Sbjct: 46 EPRKIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVN 99
Query: 155 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK-GPKGLGFSIAGGVGN 213
V++ +H +A ALK AG V + V + RP + E K+ + + S++ G G+
Sbjct: 100 GVNLRNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGS 158
Query: 214 QHIPGDNSIYVTKIID 229
S+YV + D
Sbjct: 159 LRTSEKRSLYVRALFD 174
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 12/122 (9%)
Query: 193 EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 252
+I L KG GLGF+I GG + I+V+ I+ GG A G L+ GDR+L VN +
Sbjct: 49 KIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVN 102
Query: 253 LEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGP-PDITHSYSPPMENHLLSGNNG 311
L THE+A A LK + V + Y + Y H M N +S +G
Sbjct: 103 LRNATHEQAAAALKRAGQSVTI-----VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSG 157
Query: 312 TL 313
+L
Sbjct: 158 SL 159
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 628 bits (1619), Expect = e-180
Identities = 319/352 (90%), Positives = 321/352 (91%), Gaps = 18/352 (5%)
Query: 519 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 578
MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW
Sbjct: 1 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 60
Query: 579 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIF 638
WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG +
Sbjct: 61 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGY-- 118
Query: 639 SRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLI 698
+ RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLI
Sbjct: 119 ----------------GTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLI 162
Query: 699 SEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTS 758
SEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTS
Sbjct: 163 SEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTS 222
Query: 759 VQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKK 818
VQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKK
Sbjct: 223 VQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKK 282
Query: 819 TYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 870
TYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Sbjct: 283 TYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 334
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 214 bits (544), Expect = 4e-55
Identities = 156/467 (33%), Positives = 231/467 (49%), Gaps = 63/467 (13%)
Query: 417 GEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476
GE K+V + + + + + + +S I+ GG A+ SG L GD++L +NGI++R
Sbjct: 251 GETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
Query: 477 GASHEQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTN 534
G + L T+T +I Q + E IH
Sbjct: 311 GKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIH--------------------- 349
Query: 535 QKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEE 592
V+A FDYD S D +P + GLSF+ GDILHVI+ D WWQA R E +
Sbjct: 350 ------VKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPL 403
Query: 593 MGVIPSKRRVERKERARLKTVKFNAKP---GVIDSKGSFNDKRKKSFIFSRKFPFYKNKE 649
G++P K +++E A +T++ + +P G + KRKK + K Y N+E
Sbjct: 404 AGLVPGKSFQQQRE-AMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEE 462
Query: 650 QSEQETSDPERGQEDLILSYEPVT--RQEINYTRPVIILGPM---KDRINDDLISEFPDK 704
IL+YE ++ Q N RP+I++GP ++ + L+++ D+
Sbjct: 463 ----------------ILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDR 506
Query: 705 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF 764
F S VPHTTR +RD EV GRDYHFV SR+ E DI KFIE G++ NLYGTS+ SVR
Sbjct: 507 FASAVPHTTRSRRDQEVAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQ 565
Query: 765 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEM----NKRLTEEQAKKTY 820
V GK C+L + ++K L+ + L P IFI P S E L + K E+ ++
Sbjct: 566 VINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREII 625
Query: 821 DRAIKLEQEFGEYF-TAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 866
++ ++EQ G YF TAIV D L+ Y + +I + W+PS
Sbjct: 626 EKTREMEQNNGHYFDTAIVNSD-LDKAYQELLRLINKLDTEPQWVPS 671
Score = 34.7 bits (78), Expect = 0.39
Identities = 15/48 (31%), Positives = 27/48 (56%)
Query: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 267
+S+ +++I+ GGAA+K G L GD +L +N + E +L +
Sbjct: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSD 323
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 198 bits (504), Expect = 2e-50
Identities = 149/479 (31%), Positives = 229/479 (47%), Gaps = 71/479 (14%)
Query: 416 EGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 475
E + + L K LG I E I V+ I+ GG AD SG + GD++ VNGI +
Sbjct: 134 EDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPV 193
Query: 476 RGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQ 535
E+ + I+AQ Q + + GS ++
Sbjct: 194 EDKRPEEI----------IQILAQSQGA----------------ITFKIIPGSKEETPSK 227
Query: 536 KRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-E 592
+ ++++A+FDY+ ++D +P + GLSFK GDIL +++ D WWQA+ E D+
Sbjct: 228 EGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKH---EADANPR 284
Query: 593 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFP-----FYKN 647
G+IPSK ER R L+ + +P + ++ S + KSF SRK Y+
Sbjct: 285 AGLIPSKHFQER--RLALRRPEILVQPLKVSNRKSSGFR--KSFRLSRKDKKTNKSMYEC 340
Query: 648 KEQSEQETSDPERGQEDLILSYEPVT---RQEINYTRPVIILGPMKDRIND---DLISEF 701
K+ + +T+D + +YE VT RQ R V+++GP+ +N+ L+
Sbjct: 341 KKSDQYDTAD--------VPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISD 392
Query: 702 PDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQS 761
+G VPHTTR +R E DG +Y F IS+ E D+Q +KFIE G+Y +N YGTS+ S
Sbjct: 393 TQHYGVTVPHTTRARRSQESDGVEYIF-ISKHLFETDVQNNKFIEYGEYKNNYYGTSIDS 451
Query: 762 VRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKR----------- 810
VR V + K C+LDV + +K L+ + P IFIKP S+E L E K
Sbjct: 452 VRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQG 511
Query: 811 ----LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 865
TEE ++ A +E ++G F I+ D L +N+ K ++ W+P
Sbjct: 512 AAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
Score = 41.6 bits (96), Expect = 0.003
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 6/88 (6%)
Query: 189 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 248
++V I+L K + LG +I + +I V +I+ GGAA + G + VGD L V
Sbjct: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
Query: 249 NNYSLEEVTHEEAVAILKNTSEVVYLKV 276
N +E+ EE + IL + + K+
Sbjct: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 182 bits (461), Expect = 2e-45
Identities = 137/482 (28%), Positives = 231/482 (47%), Gaps = 77/482 (15%)
Query: 422 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
V L K LG I E + V+ I+ GG AD SG + GD++ VNGI + +
Sbjct: 138 VRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPD 197
Query: 482 QAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 539
+ + L + ++T II Q ED + E+K+
Sbjct: 198 EISQILAQSQGSITLKIIPATQEEDRLK-ESKV--------------------------- 229
Query: 540 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-EMGVI 596
++RA+F Y+ +D +P Q GL F+ +L V++ D WWQA+RV GD+ G+I
Sbjct: 230 FMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRV---GDTNLRAGLI 286
Query: 597 PSKRRVERKERARLKTVKFNAKPGVIDSKGSFN--------DKR--------KKSFIFSR 640
PSK ER+ + + G + S S DK K ++
Sbjct: 287 PSKGFQERR-------LSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGL 339
Query: 641 KFPFY---KNKEQSEQETSDPERGQEDLILSYEPVTR---QEINYTRPVIILGPMKDRIN 694
+ F + + QE + +L+YE V R Q R V+++G + R++
Sbjct: 340 RRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLH 399
Query: 695 D---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYN 751
+ +++E P FG VPHTTRP++ +E +G +YHFV S++ E D+ +KF+E G+Y
Sbjct: 400 ELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFV-SKQAFEADLHHNKFLEHGEYK 458
Query: 752 DNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR--------SLEP 803
+NLYGTS+++++ V + K C++DV A+K+L+ ++ P IF+KP + P
Sbjct: 459 ENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSP 518
Query: 804 LMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIW 863
E +EQ ++ A +++ +G A++ + L+ Y+Q K+V+E+ S W
Sbjct: 519 ACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHW 578
Query: 864 IP 865
+P
Sbjct: 579 VP 580
Score = 38.1 bits (87), Expect = 0.036
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 189 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 248
E+V ++L K + LG +I ++H ++ V +I+ GGAA + G + VGD L V
Sbjct: 133 ESVKIVRLVKNKEPLGATIRR---DEH---SGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 249 NNYSLEEVTHEEAVAILKNTSEVVYLKV 276
N ++ +E IL + + LK+
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKI 214
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 178 bits (452), Expect = 2e-44
Identities = 131/453 (28%), Positives = 215/453 (47%), Gaps = 74/453 (16%)
Query: 430 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489
G+ F + GGE + ++ IL GG G L GD I VNG + G+ L+
Sbjct: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRN 206
Query: 490 AGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDY 547
A +V I+ YQ + R ++V+ FDY
Sbjct: 207 ASGSVILKILPSYQ------------------------------EPHLPRQVFVKCHFDY 236
Query: 548 DKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERK 605
D ++DS +P + GL F GD+L ++N D WWQA V EG S G+IPS+ E++
Sbjct: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHV--EGGSA--GLIPSQLLEEKR 292
Query: 606 ERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDL 665
+ + ++ G + GS + K+KK ++ KN E E
Sbjct: 293 KAFVKRDLELTPNSGTLC--GSLSGKKKKRMMYLTT----KNAEFDRHE----------- 335
Query: 666 ILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVD 722
+L YE V R + ++++G + + + LI PD++G+ VP+T+R +D E +
Sbjct: 336 LLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSERE 395
Query: 723 GRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIK 782
G+ Y FV SR +ME D++ +++E G+Y NLYGT + S+R V GK C+LDV+ A+K
Sbjct: 396 GQGYSFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVK 454
Query: 783 RLQVAQLYPIAIFIKPRSLEPLMEMN----------KRLTEEQAKKTYDRAIKLEQEFGE 832
L+ A+ P +FI+ E L MN K+LTE ++T + + ++++ +G
Sbjct: 455 VLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGH 514
Query: 833 YFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 865
YF + LE + + + +E+ W+P
Sbjct: 515 YFDLCLVNSNLERTFRELQTAMEKLRTEPQWVP 547
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 172 bits (437), Expect = 9e-43
Identities = 172/705 (24%), Positives = 298/705 (42%), Gaps = 147/705 (20%)
Query: 182 RRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 241
R+ RP +E +K+ KG + LG SI G IYV+K+ G A + G L+
Sbjct: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390
Query: 242 GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPM 301
GD+LL N +L T ++A I+ + + I Y+P +
Sbjct: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTI-------------------TILAQYNPHV 1431
Query: 302 ENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASP 361
H LS ++ S P H + T PE S ++ L ++ P
Sbjct: 1432 --HQLSSHSR-----------SSSHLDPAGTHSTLQGSGTTTPEHP-SVIDPLMEQDEGP 1477
Query: 362 RHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK 421
P ++ +S A ++ TL EPR
Sbjct: 1478 S------------------------TPPAKQSSSRIAGDANKK---TL--------EPRV 1502
Query: 422 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
V + K LG ++ GG + G+FV+ + PA L GD IL +D+R + E
Sbjct: 1503 VFIKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVE 1561
Query: 482 QAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYV 541
+ + V + QY+PE++ + + D S Y+
Sbjct: 1562 EVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYI 1598
Query: 542 RAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPS 598
RA+ YD+ D Q LSFK DIL+V + W A ++ + G IPS
Sbjct: 1599 RAL--YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPS 1653
Query: 599 KRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQE---- 654
K ++++ RL + + + ++SF F RK +K+K ++
Sbjct: 1654 KYVMDQEFSRRLSMSEVKDDNSATKTLSA---AARRSF-FRRK---HKHKRSGSKDGKDL 1706
Query: 655 ------TSDPERGQEDLI-LSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGS 707
+SD ED + L+Y+ V + + RPV+ILGP+ D + + L++E P KF
Sbjct: 1707 LALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCR 1766
Query: 708 CVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE 767
C + S++ +E+ +++ F++ + + + T+V S++ + E
Sbjct: 1767 CPLEVMKA---------------SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITE 1811
Query: 768 RGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME------MNKRLTEEQAKKTYD 821
+ +HC+LD++ +AI+RL +YPI IFI +S + + E + ++T+ +K+ ++
Sbjct: 1812 KNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFE 1871
Query: 822 RAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 866
A KLEQE+ YFT ++QG L I Q ++ ++ +WIP+
Sbjct: 1872 AAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
Score = 102 bits (255), Expect = 1e-21
Identities = 77/243 (31%), Positives = 125/243 (51%), Gaps = 30/243 (12%)
Query: 40 ELVHVSEKNLSQIENVHGY-VLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEE 98
EL + E+ SQ+E + L +H S A ++TD+++ V E E E E+
Sbjct: 578 ELKELKEQMESQLEKEARFRQLMAHSSHDSA------IDTDSMEWETEV--VEFERETED 629
Query: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
I L+ LGF +A G + P D GIF+TK+ G A DGRLRVND +LR+N+VD+
Sbjct: 630 IDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDL 683
Query: 159 SEVSHSKAVEALKEAGSIVRLYVRRRRPI---LETVVEIKLFKGPKGLGFSIAGGVGNQH 215
+A++AL + + VRRR+ + + T + I L G K G S+
Sbjct: 684 INKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINL-SGQKDSGISL-------- 734
Query: 216 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 275
+N +Y ++ G A K+G L VGDR++ +N +L+ + E ++L++ + + L
Sbjct: 735 ---ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLS 791
Query: 276 VGK 278
+ K
Sbjct: 792 LLK 794
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 412 AVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQ 466
A+++ RK + K T L N+ G +D G++ + +L G PA G L GD+
Sbjct: 701 AINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDR 760
Query: 467 ILSVNGIDLRGASHEQAAAALKGAGQTVTI 496
I+++NGI L S + + L+ ++T+
Sbjct: 761 IVAINGIALDNKSLNECESLLRSCQDSLTL 790
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 169 bits (427), Expect = 1e-41
Identities = 134/505 (26%), Positives = 226/505 (44%), Gaps = 88/505 (17%)
Query: 420 RKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479
R V L K LG I E I V+ I+ GG A+ SG L GD+++ VNG+ + G
Sbjct: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
Query: 480 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 539
EQ L + T+ K+ + + +N ++ +
Sbjct: 213 PEQVIHILAMSRGTIMF--------------KVVPVSDPPVN-------------SQQMV 245
Query: 540 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 597
YVRAM +Y +D +P GL F+ GDIL +++ +D WWQAR++ + G++P
Sbjct: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI--SDPATCAGLVP 303
Query: 598 SKRRVERKERARLKTVKFNA----KPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQ 653
S ++RK+R + + K + S +D + ++++E SE
Sbjct: 304 SNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSED 363
Query: 654 ETSDPERGQEDLILS----------------------------------YEPVTRQEINY 679
+ GQ+ I YE V R +
Sbjct: 364 KEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRP 423
Query: 680 T---RPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISRE 733
+ R ++++GP +N+ LI P F S VPHTTR K+ YE++GR+YH+V S+E
Sbjct: 424 SDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYV-SKE 482
Query: 734 QMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIA 793
E I H+ +E G+Y +LYGTSV +V+ V GK C++D+ I+ ++ +L P
Sbjct: 483 TFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYV 542
Query: 794 IFIKPRSLEPLMEMNK------------RLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD 841
IFIKP ++ + + K + +E ++ + A ++E +FG++F ++ D
Sbjct: 543 IFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVND 602
Query: 842 TLEDIYNQCKLVIEEQSGPFIWIPS 866
+L D Q I++ W+P+
Sbjct: 603 SLHDACAQLLSAIQKAQEEPQWVPA 627
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 6/81 (7%)
Query: 196 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 255
L K + LG +I + GD I V +II GG A++ G L GD+L+ VN S+E
Sbjct: 157 LVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEG 210
Query: 256 VTHEEAVAILKNTSEVVYLKV 276
+ E+ + IL + + KV
Sbjct: 211 LDPEQVIHILAMSRGTIMFKV 231
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 167 bits (424), Expect = 3e-41
Identities = 127/445 (28%), Positives = 209/445 (46%), Gaps = 76/445 (17%)
Query: 440 DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--II 497
+ + ++ IL GG D G L GD I VNG ++ G + ++ LK +VT I+
Sbjct: 148 ENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELLKNISGSVTLKIL 206
Query: 498 AQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPS 557
Y+ T + ++V+ FDY+ D+ +P
Sbjct: 207 PSYRD------------------------------TITPQQVFVKCHFDYNPYNDNLIPC 236
Query: 558 Q--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKF 615
+ GL F G+IL ++N D WWQA V G + G+IPS+ +E K +A ++
Sbjct: 237 KEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSA---GLIPSQF-LEEKRKAFVRRDWD 292
Query: 616 NAKP--GVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVT 673
N+ P G I SK K+K ++ +R F +++ Q YE V
Sbjct: 293 NSGPFCGTISSK----KKKKMMYLTTRNAEFDRHEIQI-----------------YEEVA 331
Query: 674 RQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVI 730
+ + ++++G + + + I P +FG+ VP T+R R+ E DG+ Y FV
Sbjct: 332 KMPPFQRKTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFV- 390
Query: 731 SREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLY 790
SR +ME DI+ K++E G+Y NLYGT + S+ V + G+ CILDV+ A+K L+ ++
Sbjct: 391 SRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFM 450
Query: 791 PIAIFIKPRSLEPLMEMNKR----------LTEEQAKKTYDRAIKLEQEFGEYFTAIVQG 840
P +FI LE L M+K LT+ KKT D + ++++ + YF I+
Sbjct: 451 PYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIIN 510
Query: 841 DTLEDIYNQCKLVIEEQSGPFIWIP 865
D L+ + + + IE+ W+P
Sbjct: 511 DNLDKAFEKLQTAIEKLRMEPQWVP 535
Score = 34.7 bits (78), Expect = 0.39
Identities = 19/58 (32%), Positives = 31/58 (53%), Gaps = 1/58 (1%)
Query: 219 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
+N + + +I+ GG + G L VGD + VN + + +E +LKN S V LK+
Sbjct: 149 NNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGN-NPKELQELLKNISGSVTLKI 205
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 158 bits (399), Expect = 2e-38
Identities = 114/432 (26%), Positives = 208/432 (48%), Gaps = 42/432 (9%)
Query: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 503
V+ I+ GG G L GD+I +NGI + + EQ L+ ++T I+ Y+ +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574
Query: 504 DYARFEAKIHDLREQMMN-HSMSSGSGS---LRTNQK-RSLYVRAMFDYDKSKDSGLPSQ 558
+ R+ N HS ++ S S T K R +YVRA F+YD +KD +P +
Sbjct: 575 SSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCK 634
Query: 559 --GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFN 616
G+ F+ GDI+ +I+ D WWQ + + + G+IPS E +
Sbjct: 635 EAGIRFRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEWRVAC-------- 684
Query: 617 AKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQE 676
I + + +++ F +K YK+K ++ +++YE V +
Sbjct: 685 -----IAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAD---------LVTYEEVVKLP 730
Query: 677 INYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISRE 733
+ +++LG + I + LI++ PD+F +PHTTRP + E +G++Y+FV S +
Sbjct: 731 AFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHD 789
Query: 734 QMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIA 793
QM +DI ++++E G + D +YGT ++++R + E+G ILDV A+K L+ A+ P
Sbjct: 790 QMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFV 849
Query: 794 IFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLV 853
+FI ++ P + ++ L Q + L++ + YF + + +++ +
Sbjct: 850 VFIAAPTITPGLNEDESLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEA 904
Query: 854 IEEQSGPFIWIP 865
+E W+P
Sbjct: 905 VELVCTAPQWVP 916
Score = 32.7 bits (73), Expect = 1.5
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
N V +I+ GG + G L VGD + +N S+ T E+ +L+ + K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 156 bits (395), Expect = 7e-38
Identities = 114/426 (26%), Positives = 198/426 (46%), Gaps = 66/426 (15%)
Query: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDY 505
V+ IL GG G L GD+IL +NG ++ S +Q A+K +++ + P
Sbjct: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
Query: 506 ARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFK 563
+R A +++RA FDYD KD+ +P + GL F
Sbjct: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
Query: 564 YGDILHVINASDDEWWQARRVMLEGDSEE-MGVIPSKRRVERKERARLKTVKFNAKPGVI 622
GDI+ +IN D WWQ R +EG S+E G+IPS E + + ++ P
Sbjct: 188 TGDIIQIINKDDSNWWQGR---VEGSSKESAGLIPSPELQEWRVASMAQSA-----PSEA 239
Query: 623 DSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRP 682
S F K+K YK+K ++ + + ++SYE V R +
Sbjct: 240 PSCSPFGKKKK-----------YKDKYLAKHSSIFDQLD----VVSYEEVVRLPAFKRKT 284
Query: 683 VIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDI 739
++++G + I + L+S+ P+KF VP+TTRP R E DG++YHF IS E+M ++I
Sbjct: 285 LVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHF-ISTEEMTRNI 343
Query: 740 QEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR 799
++F+E G Y N++GT ++V + ++ K ILD+ +K ++ A+L P +FI P
Sbjct: 344 SANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPT 403
Query: 800 SLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSG 859
E ++L ++ + ++ YF + + +++ + + ++
Sbjct: 404 DQGTQTEALQQLQKDSE--------AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACS 455
Query: 860 PFIWIP 865
W+P
Sbjct: 456 SPQWVP 461
Score = 35.4 bits (80), Expect = 0.23
Identities = 17/56 (30%), Positives = 30/56 (53%)
Query: 221 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
S V +I+ GG + G L VGD +L +N ++ + ++ +K T ++ LKV
Sbjct: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
Score = 35.4 bits (80), Expect = 0.23
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 12/121 (9%)
Query: 129 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV----RRR 184
+ +I+ GG G L V D IL +N +V+ S + +A+KE ++ L V + R
Sbjct: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
Query: 185 RPILETVVEIKLFKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKD 236
P L+ + + P K G A G Q I D+S + ++G + +
Sbjct: 156 LPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
Query: 237 G 237
G
Sbjct: 216 G 216
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 156 bits (394), Expect = 9e-38
Identities = 165/686 (24%), Positives = 275/686 (40%), Gaps = 156/686 (22%)
Query: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 279
+ I++ I D G A + LQ GD +L +N S + ++ L +T ++ GK
Sbjct: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLS-------LNDTRRLIEKSEGKL 283
Query: 280 TTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP-ISPGRYSPIPKHMLVDD 338
+ + + D ++ ++PP +S SP+ + + + D
Sbjct: 284 SLLVLRDRG-------------------------QFLVNIPPAVSDSDSSPLEEGVTMAD 318
Query: 339 DYTRPPEPVYSTVNKLCDKPAS-----PRHY--SPVECDKSFLLSAPYSHYHLGLLPDSE 391
+ + PP + ++L P S PRH SP + +P + +
Sbjct: 319 EMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTI 378
Query: 392 MTSHSQHSTATRQPSMTLQRAVSLEG--------EPRKVVLHKGSTGLGFNIVGGEDGEG 443
Q S R+ S + R S + + R V KG + +G + GG D G
Sbjct: 379 SEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGND-VG 436
Query: 444 IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQ 501
IFVS + AG PAD G +Q GDQIL VN + + + E+A L G G+ + ++ Q +
Sbjct: 437 IFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRK 495
Query: 502 PEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGL 560
+ + + ++++ D S Y+R F+ + S P GL
Sbjct: 496 QDIFWKMVQSRVGD-----------------------SFYIRTHFELEPS-----PPSGL 527
Query: 561 SFKYGDILHVINA---------SDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLK 611
F GD+ HV++ + W A R+ + +E G+IP++ R E + A L+
Sbjct: 528 GFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAE--QLASLE 585
Query: 612 TVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---- 667
+ G S GS + + F++ + +R +EDL
Sbjct: 586 AAQRAVGVGPGSSAGS-----------NARAEFWRLRGLRRGAKKTTQRSREDLSALTRQ 634
Query: 668 ----SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF--GSCVPHTTRPKRDYEV 721
YE V +E ++ RPV+ILGP+ D L +E PD+F V T P + ++
Sbjct: 635 GRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKL 694
Query: 722 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 781
D +VR +AE+ KH +LDV+ +AI
Sbjct: 695 D--------------------------------------TVRVIAEKDKHALLDVTPSAI 716
Query: 782 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIV 838
+RL Q YPI +F P S L + + L + ++ Y +A KL + FTA +
Sbjct: 717 ERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATI 776
Query: 839 Q-GDTLEDIYNQCKLVIEEQSGPFIW 863
T + Y + K +I EQ IW
Sbjct: 777 PLNGTSDTWYQELKAIIREQQTRPIW 802
Score = 55.1 bits (131), Expect = 3e-07
Identities = 34/90 (37%), Positives = 54/90 (60%), Gaps = 7/90 (7%)
Query: 196 LFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 254
L K P+ G G +I+GG + PG S+ V+ ++ GG A+ GRLQ GD ++MVN S+E
Sbjct: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSME 86
Query: 255 EVTHEEAVAILKNTSEVVYLKVGKPTTIYM 284
T A+ ILK +++ + V +P I++
Sbjct: 87 NATSAFAIQILKTCTKMANITVKRPRRIHL 116
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 12/81 (14%)
Query: 410 QRAVSLEGEPRKVVLHKGSTGLGFNIVGGED--GEGIFVSFILAGGPADLSGELQRGDQI 467
Q +L +PR+ G G I GG D G + VS ++ GGPA+ G LQ GD I
Sbjct: 28 QHTATLSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHI 77
Query: 468 LSVNGIDLRGASHEQAAAALK 488
+ VNG+ + A+ A LK
Sbjct: 78 VMVNGVSMENATSAFAIQILK 98
Score = 39.3 bits (90), Expect = 0.016
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 9/72 (12%)
Query: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253
++ KG K +G +AGG D I+V+ + G A G +Q GD++L VN+
Sbjct: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
Query: 254 EEVTHEEAVAIL 265
+ +T EEAV L
Sbjct: 468 QNLTREEAVQFL 479
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 152 bits (385), Expect = 1e-36
Identities = 111/427 (25%), Positives = 204/427 (47%), Gaps = 50/427 (11%)
Query: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 503
V+ I+ GG G L GD+I +NGI + + EQ L+ ++T I+ Y+ +
Sbjct: 509 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 568
Query: 504 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLS 561
+ E + + + G R +YVRA F+YD +KD +P + G+
Sbjct: 569 SSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDLIPCKEAGIR 610
Query: 562 FKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGV 621
F+ GDI+ +I+ D WWQ + + + G+IPS E +
Sbjct: 611 FRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEWRVAC------------- 655
Query: 622 IDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTR 681
I + + +++ F +K YK+K ++ Q DL+ +YE V + +
Sbjct: 656 IAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFD---QLDLV-TYEEVVKLPAFKRK 711
Query: 682 PVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKD 738
+++LG + I + LI++ PD+F +PHTTRP + E +G++Y+FV S +QM +D
Sbjct: 712 TLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQD 770
Query: 739 IQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKP 798
I ++++E G + D +YGT ++++R + E+G ILDV A+K L+ A+ P +FI
Sbjct: 771 ISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAA 830
Query: 799 RSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQS 858
++ P + ++ L Q + L++ + YF + + +++ + +E
Sbjct: 831 PTITPGLNEDESLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVC 885
Query: 859 GPFIWIP 865
W+P
Sbjct: 886 TAPQWVP 892
Score = 32.7 bits (73), Expect = 1.5
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
N V +I+ GG + G L VGD + +N S+ T E+ +L+ + K+
Sbjct: 505 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 561
Score = 30.8 bits (68), Expect = 5.7
Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 6/126 (4%)
Query: 83 TIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNP-----HIGDDPGIFITKIIPGGA 137
T PY+NG E ++ +E TD P + + + +I+ GG
Sbjct: 458 TSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGM 517
Query: 138 AAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKE-AGSIVRLYVRRRRPILETVVEIKL 196
G L V D I +N + V+ + + + L+E GSI V R + ++
Sbjct: 518 IHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPS 577
Query: 197 FKGPKG 202
PKG
Sbjct: 578 TTQPKG 583
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 152 bits (385), Expect = 1e-36
Identities = 108/427 (25%), Positives = 202/427 (47%), Gaps = 55/427 (12%)
Query: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 503
V+ I+ GG G L GD+I +NGI + + EQ L+ ++T I+ Y+ +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574
Query: 504 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLS 561
+ E + + + G R +YVRA F+YD +KD +P + G+
Sbjct: 575 SSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDLIPCKEAGIR 616
Query: 562 FKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGV 621
F+ GDI+ +I+ D WWQ + + + G+IPS E +
Sbjct: 617 FRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEWRVAC------------- 661
Query: 622 IDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTR 681
I + + +++ F +K YK+K ++ +++YE V + +
Sbjct: 662 IAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAD---------LVTYEEVVKLPAFKRK 712
Query: 682 PVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKD 738
+++LG + I + LI++ PD+F +PHTTRP + E +G++Y+FV S +QM +D
Sbjct: 713 TLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQD 771
Query: 739 IQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKP 798
I ++++E G + D +YGT ++++R + E+G ILDV A+K L+ A+ P +FI
Sbjct: 772 ISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAA 831
Query: 799 RSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQS 858
++ P + ++ L Q + L++ + YF + + +++ + +E
Sbjct: 832 PTITPGLNEDESLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVC 886
Query: 859 GPFIWIP 865
W+P
Sbjct: 887 TAPQWVP 893
Score = 32.7 bits (73), Expect = 1.5
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
N V +I+ GG + G L VGD + +N S+ T E+ +L+ + K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567
Score = 30.8 bits (68), Expect = 5.7
Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 6/126 (4%)
Query: 83 TIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNP-----HIGDDPGIFITKIIPGGA 137
T PY+NG E ++ +E TD P + + + +I+ GG
Sbjct: 464 TSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGM 523
Query: 138 AAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKE-AGSIVRLYVRRRRPILETVVEIKL 196
G L V D I +N + V+ + + + L+E GSI V R + ++
Sbjct: 524 IHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPS 583
Query: 197 FKGPKG 202
PKG
Sbjct: 584 TTQPKG 589
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 145 bits (366), Expect = 2e-34
Identities = 164/621 (26%), Positives = 264/621 (42%), Gaps = 106/621 (17%)
Query: 17 RYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV 76
R Q E+ + P+ E E E+ ++ E+ G V+ ++P+ V
Sbjct: 656 RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVV--------SAPSVKGV 707
Query: 77 NTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPG 135
+ D + + + IE E +T+ R GLG SIAGG + P+ GDD GIFI+++
Sbjct: 708 SFDQANNL-LIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
Query: 136 GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI-LETVVEI 194
G AA G +RV D +L VN V + H +AVEAL+ AG+ V++ V R R + E V I
Sbjct: 767 GPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTI 825
Query: 195 K--------------------------------------LFKGPKGLGFSIAGGVGN-QH 215
L + +GLGFSIAGG G+ +
Sbjct: 826 TPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPY 885
Query: 216 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 275
GD I+V++I +GGAA + G LQVGDR+L +N + E H+ AV++L S + L
Sbjct: 886 RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
Query: 276 VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP--------GRY 327
+ + P P + HS SPP + LP ++P G Y
Sbjct: 946 LEREA----GGPLPPSPLPHS-SPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
Query: 328 -----------SPIPKHMLVDDDYTRPPEPVYST---VNKLCDKPASPRHYSPVECDKSF 373
P+ ++ D++ P V ++K+ + + R V D+
Sbjct: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG-DRIL 1059
Query: 374 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-ST 429
++ D +H + +A +P + L V + P R++ + K
Sbjct: 1060 AVNG----------QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGE 1109
Query: 430 GLGFNIVGGEDG----------EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479
LG +I GG G EGIF+S + G A G L+ G ++L VN L G +
Sbjct: 1110 RLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
Query: 480 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 539
H +A L+ G T+T++ E A +A + ++ ++ + ++G G + + S
Sbjct: 1170 HGEAVQLLRSVGDTLTVLVCDGFE--ASTDAAL-EVSPGVIANPFAAGIGHRNSLESISS 1226
Query: 540 YVRAMFDYDKSKDSGLPSQGL 560
R + K+ LP Q L
Sbjct: 1227 IDRELSPEGPGKEKELPGQTL 1247
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 145 bits (366), Expect = 2e-34
Identities = 164/621 (26%), Positives = 264/621 (42%), Gaps = 106/621 (17%)
Query: 17 RYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV 76
R Q E+ + P+ E E E+ ++ E+ G V+ ++P+ V
Sbjct: 656 RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVV--------SAPSVKGV 707
Query: 77 NTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPG 135
+ D + + + IE E +T+ R GLG SIAGG + P+ GDD GIFI+++
Sbjct: 708 SFDQANNL-LIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
Query: 136 GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI-LETVVEI 194
G AA G +RV D +L VN V + H +AVEAL+ AG+ V++ V R R + E V I
Sbjct: 767 GPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTI 825
Query: 195 K--------------------------------------LFKGPKGLGFSIAGGVGN-QH 215
L + +GLGFSIAGG G+ +
Sbjct: 826 TPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPY 885
Query: 216 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 275
GD I+V++I +GGAA + G LQVGDR+L +N + E H+ AV++L S + L
Sbjct: 886 RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
Query: 276 VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP--------GRY 327
+ + P P + HS SPP + LP ++P G Y
Sbjct: 946 LEREA----GGPLPPSPLPHS-SPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
Query: 328 -----------SPIPKHMLVDDDYTRPPEPVYST---VNKLCDKPASPRHYSPVECDKSF 373
P+ ++ D++ P V ++K+ + + R V D+
Sbjct: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG-DRIL 1059
Query: 374 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-ST 429
++ D +H + +A +P + L V + P R++ + K
Sbjct: 1060 AVNG----------QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGE 1109
Query: 430 GLGFNIVGGEDG----------EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479
LG +I GG G EGIF+S + G A G L+ G ++L VN L G +
Sbjct: 1110 RLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
Query: 480 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 539
H +A L+ G T+T++ E A +A + ++ ++ + ++G G + + S
Sbjct: 1170 HGEAVQLLRSVGDTLTVLVCDGFE--ASTDAAL-EVSPGVIANPFAAGIGHRNSLESISS 1226
Query: 540 YVRAMFDYDKSKDSGLPSQGL 560
R + K+ LP Q L
Sbjct: 1227 IDRELSPEGPGKEKELPGQTL 1247
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 139 bits (349), Expect = 1e-32
Identities = 143/462 (30%), Positives = 203/462 (43%), Gaps = 64/462 (13%)
Query: 70 SPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFI 129
S P I +D T P + G E E + +G +GLG SI GG+D +G I I
Sbjct: 1607 SSTPAIFASDPA-TCPIIPGCETTIE-----ISKGRTGLGLSIVGGSDTL-LG---AIII 1656
Query: 130 TKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR-RRPIL 188
++ GAA +DGRL D IL VN +D+ + +H +A+ L++ VRL + R P
Sbjct: 1657 HEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYK 1716
Query: 189 ETVV----EIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGD 243
E V I+L K P KGLG SI G D ++V+ I+ GG A DGRL GD
Sbjct: 1717 EEEVCDTLTIELQKKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGD 1770
Query: 244 RLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSY-SPPME 302
++LMVN + T +EAVA L LKV + + T P + S S +
Sbjct: 1771 QILMVNGEDVRNAT-QEAVAAL--------LKVSEGSLSSFTFPLSGSSTSESLESSSKK 1821
Query: 303 NHLLSGNNGTLEYKTSLPP-------ISPGRYSPI-----------PKHMLVDDDYTRPP 344
N L S G + P I+ G SP+ P + R
Sbjct: 1822 NALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVG 1881
Query: 345 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 404
+ + + + H V K+ S G + S +T H Q ++
Sbjct: 1882 DRIVTICGTSTE---GMTHTQAVNLLKNASGSIEMQVVAGGDV--SVVTGHQQEPASSSL 1936
Query: 405 PSMTLQRAVSLE---GEP--RKVVLHKGSTGLGFNIVGGEDGEG----IFVSFILAGGPA 455
L + + G P + + L +G GLGF+IVGG I+V + A G A
Sbjct: 1937 SFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAA 1996
Query: 456 DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 497
G L+RGDQI++VNG L G +HE+A A LK TVT++
Sbjct: 1997 SEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
Score = 119 bits (297), Expect = 2e-26
Identities = 91/274 (33%), Positives = 135/274 (49%), Gaps = 42/274 (15%)
Query: 36 VRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYE 95
V G ++ + +++ ++ + V L S PL S +++L++ N E +
Sbjct: 1775 VNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSST-----SESLESSSKKNALASEIQ 1829
Query: 96 -FEEITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRV 153
+ +++G LG SIAGG +P +GD P IFI + P G AA+ +LRV D I+ +
Sbjct: 1830 GLRTVEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPTGVAAQTQKLRVGDRIVTI 1887
Query: 154 NEVDVSEVSHSKAVEALKEAGSIVRLYV-----------RRRRPILETVV---------- 192
++H++AV LK A + + V ++ P ++
Sbjct: 1888 CGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIF 1947
Query: 193 ----------EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVG 242
I L +GP GLGFSI GG G+ H GD IYV + GAA +DGRL+ G
Sbjct: 1948 QDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRG 2005
Query: 243 DRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
D+++ VN SLE VTHEEAVAILK T V L V
Sbjct: 2006 DQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 110 bits (275), Expect = 6e-24
Identities = 109/462 (23%), Positives = 195/462 (42%), Gaps = 98/462 (21%)
Query: 72 APIIVNTDTLDTIPYVNGTEIEYE-FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 130
+PI+ + + + + + ++ E I L SGLGF I GG G+ +
Sbjct: 230 SPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT-------GVIVK 282
Query: 131 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR------- 183
I+PGG A + GRL D IL++ + D++ +S + + L++ G+ V+L + R
Sbjct: 283 TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERT 342
Query: 184 --------------RRPILET-----------VVEIKLFKGPKGLGFSIAGGVGNQHIPG 218
P L +++L K +GLG +IAG +G++ +
Sbjct: 343 APTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLE- 401
Query: 219 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 278
+ I+V I A + DGR+Q+GD+++ V+ +L+ T+++AV +L++T + V L + +
Sbjct: 402 PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
Query: 279 PTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD 338
E L+S + T + L P++ ++ +
Sbjct: 462 ------------------RGMKQEAELMSREDVTKD--ADLSPVNAS---------IIKE 492
Query: 339 DYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQH 398
+Y + + + ST N + P E + LLSA + E +Q
Sbjct: 493 NYEKDEDFLSSTRN---------TNILPTEEEGYPLLSA-----------EIEEIEDAQK 532
Query: 399 STATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI---VGGEDGEGIFVSFILAGGPA 455
A ++ E V ++GLG ++ VG F+ +L GP
Sbjct: 533 QEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH-----FIRSVLPEGPV 587
Query: 456 DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 497
SG+L GD++L VNGI L G +H+ LK VT++
Sbjct: 588 GHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 99.4 bits (246), Expect = 1e-20
Identities = 112/475 (23%), Positives = 182/475 (38%), Gaps = 131/475 (27%)
Query: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
I + +GNS LG +++ D G+ + II GGA + DGR+ + DCIL +NE
Sbjct: 1009 INIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
Query: 159 SEVSHSKAVEALK----------------------------EAGSIVRL-----YVRRRR 185
V++++A L+ ++G ++ L Y R
Sbjct: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
Query: 186 PILETVVE---------------------IKLFKGP-KGLGFSIAGG--VGNQHIPGD-- 219
P L E ++L++ P K LG SI GG +G++ G+
Sbjct: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
Query: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 279
I++ +++ A K+G L+ GDR++ V+ L + +HE+AV ++ K G P
Sbjct: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR--------KAGNP 1234
Query: 280 TTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK--HMLVD 337
+ P R SP+P H L
Sbjct: 1235 VVFMVQSIINRP----------------------------------RKSPLPSLLHNLYP 1260
Query: 338 DDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQ 397
P ++ DK S P + + P S + +EM S
Sbjct: 1261 KYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAF-------AEMGSDHT 1313
Query: 398 HSTATRQPSMT-------------LQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGE-- 442
S+A++ +R +L GE + L KG +GLG ++ G +D
Sbjct: 1314 QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM 1373
Query: 443 GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 497
+F+ I G A G LQ D++L +NG L G SH+ A++ +K A V II
Sbjct: 1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKII 1428
Score = 85.9 bits (211), Expect = 1e-16
Identities = 127/459 (27%), Positives = 177/459 (38%), Gaps = 123/459 (26%)
Query: 116 TDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS 175
T+ PH+ D G FI G + ED L + D EV +A A+ EAG
Sbjct: 654 TEKPHV--DLGEFI-----GSSETEDPVLAMTDAGQSTEEV--------QAPLAMWEAG- 697
Query: 176 IVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQK 235
+ I+L KG KGLGFSI + P I + ++ GG A+K
Sbjct: 698 ---------------IQHIELEKGSKGLGFSILD-YQDPIDPASTVIIIRSLVPGGIAEK 741
Query: 236 DGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT-SEVVYLKVGKPTTI-----YMT---- 285
DGRL GDRL+ VN+ +LE + EEAV LK S V + V KP + Y++
Sbjct: 742 DGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKED 801
Query: 286 -----------------------------------------DPYGPPD--ITHSYSPPME 302
PY P + I + + +
Sbjct: 802 SFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILS 861
Query: 303 NHLLSGNNGTLEYKTSLPPISP-----GRYSPI-PKHMLVDDDYT-----RPPEPVYS-- 349
H S +G L Y +SLP P P+ HM +++ YT R E S
Sbjct: 862 LHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVD 920
Query: 350 ---------TVNKLCDKPASPRHYSPVECD------KSFLLSAPYSHYHL-GLLPDSEMT 393
T+N A + Y EC+ +S L S S L +LPDS
Sbjct: 921 ISMGPASGFTINDYTPANAIEQQY---ECENTIVWTESHLPSEVISSAELPSVLPDSAGK 977
Query: 394 SHS----QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFI 449
Q S A + LQ VS E R + + KG++ LG + +DG G+ V I
Sbjct: 978 GSEYLLEQSSLACNAECVMLQN-VSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSI 1036
Query: 450 LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488
+ GG G + GD ILS+N ++ QA A L+
Sbjct: 1037 IHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 85.5 bits (210), Expect = 2e-16
Identities = 90/311 (28%), Positives = 131/311 (42%), Gaps = 84/311 (27%)
Query: 194 IKLFKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 250
I + KG LG +++ G+G + V II GGA +DGR+ +GD +L +N
Sbjct: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
Query: 251 YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 310
S VT+ +A A+L+ S + PDI +Y P HL
Sbjct: 1060 ESTISVTNAQARAMLRRHSLI------------------GPDIKITYVPA--EHLE---- 1095
Query: 311 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECD 370
E+K SL G+ S + + YT D P P E +
Sbjct: 1096 ---EFKISL-----GQQSGRVMALDIFSSYTGR------------DIPELPEREEG-EGE 1134
Query: 371 KSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKV--VLHKGS 428
+S L + YS+++ QP R V L EP K + G
Sbjct: 1135 ESELQNTAYSNWN--------------------QP-----RRVELWREPSKSLGISIVGG 1169
Query: 429 TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488
G+G + GE GIF+ +L PA +G L+ GD+I+ V+G+DLR ASHEQA A++
Sbjct: 1170 RGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229
Query: 489 GAGQTVTIIAQ 499
AG V + Q
Sbjct: 1230 KAGNPVVFMVQ 1240
Score = 75.9 bits (185), Expect = 2e-13
Identities = 82/337 (24%), Positives = 138/337 (40%), Gaps = 66/337 (19%)
Query: 3 FACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQS 62
F+ +L+T+V++ + Q A T + + H+S + ++N ++L
Sbjct: 45 FSQILSLQTSVQQLKDQVNIATS------ATSNIEYAHVPHLSPAVIPTLQN-ESFLLSP 97
Query: 63 HISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEIT--------------LERGNSGL 108
+ L+A P IP++NG EF+++ L+ + GL
Sbjct: 98 NNGNLEALTGP---------GIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGL 148
Query: 109 GFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE-VSHSKAV 167
GFS+ G + GIF+ +I G A DGRL+ D IL +N + + ++H +A+
Sbjct: 149 GFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 168 EALKEAGSIVRLYVRR------------RRPILETVVE-------------IKLFKGPKG 202
L++A V+L + R R P + + I+L G
Sbjct: 207 SILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSG 266
Query: 203 LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAV 262
LGF I GG + V I+ GG A + GRL GD +L + + L ++ E+
Sbjct: 267 LGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVA 319
Query: 263 AILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSP 299
+L+ V L + + T P IT S SP
Sbjct: 320 QVLRQCGNRVKLMIARGAIEERTAPTA-LGITLSSSP 355
Score = 71.6 bits (174), Expect = 3e-12
Identities = 59/218 (27%), Positives = 96/218 (44%), Gaps = 40/218 (18%)
Query: 95 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154
E I LE+G+SGLG S+AG D + +FI I P GAA +DGRL++ D +L +N
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMS----VFIVGIDPNGAAGKDGRLQIADELLEIN 1402
Query: 155 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-------------------------- 188
+ SH A +K A S V++ R + +
Sbjct: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
Query: 189 -------ETVVEIKLFKGPKGLGF-SIAGGVGNQHIPGD--NSIYVTKIIDGGAAQKDGR 238
+ V++ FK + L GG+G D + + + + + G A DGR
Sbjct: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
Query: 239 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
L+VGD++L V++ + E+ +++LK V L +
Sbjct: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 61.2 bits (147), Expect = 4e-09
Identities = 44/118 (37%), Positives = 63/118 (53%), Gaps = 4/118 (3%)
Query: 73 PIIVNTDTLDTIPYVNGTEIEYE--FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 130
P++ TD + V +E + I LE+G+ GLGFSI D P I I
Sbjct: 673 PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
Query: 131 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS-IVRLYVRRRRPI 187
++PGG A +DGRL D ++ VN+V++ S +AVEALK A S VR+ V + P+
Sbjct: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPL 789
Score = 60.5 bits (145), Expect = 7e-09
Identities = 69/260 (26%), Positives = 98/260 (37%), Gaps = 66/260 (25%)
Query: 87 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 146
+ G E ++ NSGLG S+ T H FI ++P G G+L
Sbjct: 544 IMGINYEIVVAHVSKFSENSGLGISLEA-TVGHH-------FIRSVLPEGPVGHSGKLFS 595
Query: 147 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRR--PILET------VVEIKLFK 198
D +L VN + + +H V LKE V + RR P ++ + +I+L +
Sbjct: 596 GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
Query: 199 GPK-GLGFSIAGG---------------------------VGNQHI-------------- 216
P LG I G QHI
Sbjct: 656 KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
Query: 217 -------PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT- 268
P I + ++ GG A+KDGRL GDRL+ VN+ +LE + EEAV LK
Sbjct: 716 DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAP 775
Query: 269 SEVVYLKVGKPTTIYMTDPY 288
S V + V KP + + Y
Sbjct: 776 SGTVRIGVAKPLPLSPEEGY 795
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 7/129 (5%)
Query: 381 HYHLG-LLPDSEMTSHSQHSTATRQPSMTLQRAVSL-EGEPRKVVLHKGSTGLGFNIVGG 438
H LG + SE T Q + +Q +++ E + + L KGS GLGF+I+
Sbjct: 658 HVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717
Query: 439 ED-----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT 493
+D I + ++ GG A+ G L GD+++ VN ++L +S E+A ALKGA
Sbjct: 718 QDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSG 777
Query: 494 VTIIAQYQP 502
I +P
Sbjct: 778 TVRIGVAKP 786
Score = 46.6 bits (109), Expect = 1e-04
Identities = 33/80 (41%), Positives = 46/80 (57%), Gaps = 5/80 (6%)
Query: 423 VLHKGSTGLGFNIVGGED---GE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDL-RG 477
+L S GLGF++VG GE GIFV I G A G L+ DQIL++NG L +
Sbjct: 140 LLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQT 199
Query: 478 ASHEQAAAALKGAGQTVTII 497
+H+QA + L+ A TV ++
Sbjct: 200 ITHQQAISILQKAKDTVQLV 219
Score = 39.3 bits (90), Expect = 0.016
Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 6/95 (6%)
Query: 97 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 156
+ + L + GLG +I+ G+ I + G AA DGRL+V D IL V++
Sbjct: 1482 QHLELPKDQGGLGIAISEEDTLS------GVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 157 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETV 191
V K + LK A V+L + P + V
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAV 1570
Score = 38.1 bits (87), Expect = 0.036
Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 12/126 (9%)
Query: 191 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 250
V + F GLG S+ VG+ ++ ++ G G+L GD LL VN
Sbjct: 553 VAHVSKFSENSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNG 604
Query: 251 YSLEEVTHEEAVAILK----NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 306
+L H++ V ILK + V + PTT D DI + P ++
Sbjct: 605 ITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEF 664
Query: 307 SGNNGT 312
G++ T
Sbjct: 665 IGSSET 670
Score = 35.0 bits (79), Expect = 0.30
Identities = 25/81 (30%), Positives = 37/81 (45%)
Query: 424 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQA 483
L K GLG I + G+ + + G A G L+ GDQIL+V+ + G E+
Sbjct: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545
Query: 484 AAALKGAGQTVTIIAQYQPED 504
+ LK A TV + + D
Sbjct: 1546 ISLLKTAKMTVKLTIHAENPD 1566
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 138 bits (347), Expect = 3e-32
Identities = 165/696 (23%), Positives = 267/696 (38%), Gaps = 154/696 (22%)
Query: 222 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 281
I+V +I A +DG +Q GD +L +N E ++ +A +++ + + + V +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
Query: 282 IYMTDPYGPPDITHSYS------------------------PPMENHLLSGN-------- 309
+ + D HS + PP + S +
Sbjct: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDH 325
Query: 310 ---------NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDK--P 358
NG+L + PG S KH DD+T P+ V + +K P
Sbjct: 326 SRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHA---DDHT--PKTVEEVTVERNEKQTP 380
Query: 359 ASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 418
+ P K L + P + +S H +PSM L
Sbjct: 381 SLPE-------PKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKL--------- 424
Query: 419 PRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 478
V KG + +G + GG D GIFV+ +L PA G L+ GDQIL VN +D
Sbjct: 425 ---VKFRKGDS-VGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNI 478
Query: 479 SHEQAAAALKGA--GQTVTIIAQYQPEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQ 535
E+A L G+ VTI+AQ + + Y R E+ + D
Sbjct: 479 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD--------------------- 517
Query: 536 KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEE 592
S Y+R F+Y+K GLSF G++ V++ + W A R+ E
Sbjct: 518 --SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVE 570
Query: 593 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSE 652
G+IP+K R E+ L +V++ + F + F +N +S
Sbjct: 571 RGIIPNKNRAEQ-----LASVQYTLPKTAGGDRADF-------WRFRGLRSSKRNLRKSR 618
Query: 653 QETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHT 712
++ S + + +YE V +E + RPV I GP+ D + L E PD +
Sbjct: 619 EDLS--AQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIA 672
Query: 713 TRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHC 772
RD D R + + +++ + ++ KH
Sbjct: 673 KSEPRDAGTDQRSSGII----------------------------RLHTIKQIIDQDKHA 704
Query: 773 ILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE---QAKKTYDRAIKLEQE 829
+LDV+ NA+ RL AQ YPI +F+ P S + + M RL E A+K Y+R+ KL +
Sbjct: 705 LLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKN 764
Query: 830 FGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 864
FT + +++ D Y K I++Q +W+
Sbjct: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)
Query: 94 YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 151
+E +TL R G G +I+GG DNPH + I I+ ++ GG A +G+L+ ND +
Sbjct: 19 WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76
Query: 152 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 187
VN V + V H+ AV+ L+++G ++ +RR++ +
Sbjct: 77 MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
Score = 51.2 bits (121), Expect = 4e-06
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 5/92 (5%)
Query: 202 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 260
G G +I+GG N H G+ SI ++ ++ GG A+ G+LQ DR+ MVN S++ V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
Query: 261 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 292
AV L+ + + + + + + + P PD
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD 120
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 418 EPRKVVLHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 469
E V LH+ G G I GG D GE I +S +L GGPA+ G+LQ D++
Sbjct: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAM 77
Query: 470 VNGIDLRGASHEQAAAALKGAGQTVTI 496
VNG+ + H A L+ +G+ I
Sbjct: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKI 104
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)
Query: 103 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 162
R +G +AGG +D GIF+ ++ AA++G L D ILRVN VD + +
Sbjct: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 163 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 193
+AV L + G V + ++++ + +VE
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
Score = 40.8 bits (94), Expect = 0.006
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)
Query: 187 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 246
IL +++ F+ +G +AGG D I+V +++ A K+G L+ GD++L
Sbjct: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468
Query: 247 MVNNYSLEEVTHEEAVAIL 265
VNN + EEAV L
Sbjct: 469 RVNNVDFTNIIREEAVLFL 487
Score = 30.0 bits (66), Expect = 9.7
Identities = 14/57 (24%), Positives = 30/57 (52%)
Query: 127 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183
IF+ +I AA DG ++ D +L++N +S + A ++ + +++ V+R
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQR 262
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 138 bits (347), Expect = 3e-32
Identities = 165/696 (23%), Positives = 267/696 (38%), Gaps = 154/696 (22%)
Query: 222 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 281
I+V +I A +DG +Q GD +L +N E ++ +A +++ + + + V +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
Query: 282 IYMTDPYGPPDITHSYS------------------------PPMENHLLSGN-------- 309
+ + D HS + PP + S +
Sbjct: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDH 325
Query: 310 ---------NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDK--P 358
NG+L + PG S KH DD+T P+ V + +K P
Sbjct: 326 SRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHA---DDHT--PKTVEEVTVERNEKQTP 380
Query: 359 ASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 418
+ P K L + P + +S H +PSM L
Sbjct: 381 SLPE-------PKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKL--------- 424
Query: 419 PRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 478
V KG + +G + GG D GIFV+ +L PA G L+ GDQIL VN +D
Sbjct: 425 ---VKFRKGDS-VGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNI 478
Query: 479 SHEQAAAALKGA--GQTVTIIAQYQPEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQ 535
E+A L G+ VTI+AQ + + Y R E+ + D
Sbjct: 479 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD--------------------- 517
Query: 536 KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEE 592
S Y+R F+Y+K GLSF G++ V++ + W A R+ E
Sbjct: 518 --SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVE 570
Query: 593 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSE 652
G+IP+K R E+ L +V++ + F + F +N +S
Sbjct: 571 RGIIPNKNRAEQ-----LASVQYTLPKTAGGDRADF-------WRFRGLRSSKRNLRKSR 618
Query: 653 QETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHT 712
++ S + + +YE V +E + RPV I GP+ D + L E PD +
Sbjct: 619 EDLS--AQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIA 672
Query: 713 TRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHC 772
RD D R + + +++ + ++ KH
Sbjct: 673 KSEPRDAGTDQRSSGII----------------------------RLHTIKQIIDQDKHA 704
Query: 773 ILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE---QAKKTYDRAIKLEQE 829
+LDV+ NA+ RL AQ YPI +F+ P S + + M RL E A+K Y+R+ KL +
Sbjct: 705 LLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKN 764
Query: 830 FGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 864
FT + +++ D Y K I++Q +W+
Sbjct: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)
Query: 94 YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 151
+E +TL R G G +I+GG DNPH + I I+ ++ GG A +G+L+ ND +
Sbjct: 19 WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76
Query: 152 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 187
VN V + V H+ AV+ L+++G ++ +RR++ +
Sbjct: 77 MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
Score = 51.2 bits (121), Expect = 4e-06
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 5/92 (5%)
Query: 202 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 260
G G +I+GG N H G+ SI ++ ++ GG A+ G+LQ DR+ MVN S++ V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
Query: 261 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 292
AV L+ + + + + + + + P PD
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD 120
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 418 EPRKVVLHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 469
E V LH+ G G I GG D GE I +S +L GGPA+ G+LQ D++
Sbjct: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAM 77
Query: 470 VNGIDLRGASHEQAAAALKGAGQTVTI 496
VNG+ + H A L+ +G+ I
Sbjct: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKI 104
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)
Query: 103 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 162
R +G +AGG +D GIF+ ++ AA++G L D ILRVN VD + +
Sbjct: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 163 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 193
+AV L + G V + ++++ + +VE
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
Score = 40.8 bits (94), Expect = 0.006
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)
Query: 187 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 246
IL +++ F+ +G +AGG D I+V +++ A K+G L+ GD++L
Sbjct: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468
Query: 247 MVNNYSLEEVTHEEAVAIL 265
VNN + EEAV L
Sbjct: 469 RVNNVDFTNIIREEAVLFL 487
Score = 30.0 bits (66), Expect = 9.7
Identities = 14/57 (24%), Positives = 30/57 (52%)
Query: 127 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183
IF+ +I AA DG ++ D +L++N +S + A ++ + +++ V+R
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQR 262
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 137 bits (345), Expect = 4e-32
Identities = 166/677 (24%), Positives = 275/677 (40%), Gaps = 148/677 (21%)
Query: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 276
+ I+V ++ G A KDG L GD +L +N E ++ +A +++ + ++V L+
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 277 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK-HML 335
+ T I + P + S S + + N +SP + H
Sbjct: 385 SQQTLINI------PSLNDSDSEIEDISEIESNRS---------------FSPEERRHQY 423
Query: 336 VDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSH---YHLGLLPDSEM 392
D DY +S+ KL ++P+S R +P + P+ ++P++
Sbjct: 424 SDYDY-------HSSSEKLKERPSS-REDTPSRLSRMGATPTPFKSTGDIAGTVVPETNK 475
Query: 393 TSHSQHSTATRQPSMTLQRAV-------SLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF 445
Q QP + + ++ G K+V K +G + GG D GIF
Sbjct: 476 EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIF 534
Query: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPE 503
V+ I G A+ G LQ GDQIL VN D RG E A L G+ VTI+AQ + +
Sbjct: 535 VAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRAD 593
Query: 504 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFK 563
Y ++ G G S ++R+ F+ +K Q L+F
Sbjct: 594 VYRDI---------------LACGRGD-------SFFIRSHFECEKETP-----QSLAFT 626
Query: 564 YGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPG 620
G++ V++ D W A R+ G+ E G+IP+K R E+ + NA+
Sbjct: 627 RGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQR- 676
Query: 621 VIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---------SYEP 671
D+ G D F++ + Q + + +EDL +YE
Sbjct: 677 --DNAGDRAD-------------FWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYER 721
Query: 672 VTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVIS 731
V +E + RPV++ GP+ D + L +E PD F + T P
Sbjct: 722 VLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---------------- 762
Query: 732 REQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYP 791
KD K + N +VR + E+ KH +LDV+ A+ L Q +P
Sbjct: 763 -----KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFP 808
Query: 792 IAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDI-Y 847
I IF P S + + M +RL + + ++K +D+A KL++ FTA + ++ D +
Sbjct: 809 IVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWF 868
Query: 848 NQCKLVIEEQSGPFIWI 864
K I+ Q G +W+
Sbjct: 869 GSLKDTIQHQQGEAVWV 885
Score = 66.6 bits (161), Expect = 9e-11
Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 91 EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 148
E+ +E +TL++ + G G +++GG DNPH + I I+ ++PGG A DG L+ ND
Sbjct: 26 ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83
Query: 149 CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 187
++ VN + +V HS AV+ L+++G + + V+R R +
Sbjct: 84 RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
Score = 57.4 bits (137), Expect = 6e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 201 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 259
+G G +++GG N H G+ SI ++ ++ GG A DG LQ DR++MVN +E+V H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 260 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 293
AV L+ + +V + V +P + + P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)
Query: 418 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 469
E V L K S G G + GG D GE I +S +L GGPAD G LQ D+++
Sbjct: 30 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87
Query: 470 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 499
VNG + H A L+ +G+ I+ +
Sbjct: 88 VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
Score = 33.9 bits (76), Expect = 0.67
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
+ ++G+S +G +AGG +D GIF+ I G +A ++G L+ D IL+VN D
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
Query: 159 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 192
+ AV L E G +V + + R + ++
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
Score = 30.4 bits (67), Expect = 7.4
Identities = 16/57 (28%), Positives = 31/57 (54%)
Query: 127 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183
IF+ ++ G A +DG L D IL++N +S + A + ++++ ++L V R
Sbjct: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 137 bits (345), Expect = 4e-32
Identities = 166/677 (24%), Positives = 275/677 (40%), Gaps = 148/677 (21%)
Query: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 276
+ I+V ++ G A KDG L GD +L +N E ++ +A +++ + ++V L+
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 277 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK-HML 335
+ T I + P + S S + + N +SP + H
Sbjct: 385 SQQTLINI------PSLNDSDSEIEDISEIESNRS---------------FSPEERRHQY 423
Query: 336 VDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSH---YHLGLLPDSEM 392
D DY +S+ KL ++P+S R +P + P+ ++P++
Sbjct: 424 SDYDY-------HSSSEKLKERPSS-REDTPSRLSRMGATPTPFKSTGDIAGTVVPETNK 475
Query: 393 TSHSQHSTATRQPSMTLQRAV-------SLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF 445
Q QP + + ++ G K+V K +G + GG D GIF
Sbjct: 476 EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIF 534
Query: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPE 503
V+ I G A+ G LQ GDQIL VN D RG E A L G+ VTI+AQ + +
Sbjct: 535 VAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRAD 593
Query: 504 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFK 563
Y ++ G G S ++R+ F+ +K Q L+F
Sbjct: 594 VYRDI---------------LACGRGD-------SFFIRSHFECEKETP-----QSLAFT 626
Query: 564 YGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPG 620
G++ V++ D W A R+ G+ E G+IP+K R E+ + NA+
Sbjct: 627 RGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQR- 676
Query: 621 VIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---------SYEP 671
D+ G D F++ + Q + + +EDL +YE
Sbjct: 677 --DNAGDRAD-------------FWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYER 721
Query: 672 VTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVIS 731
V +E + RPV++ GP+ D + L +E PD F + T P
Sbjct: 722 VLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---------------- 762
Query: 732 REQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYP 791
KD K + N +VR + E+ KH +LDV+ A+ L Q +P
Sbjct: 763 -----KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFP 808
Query: 792 IAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDI-Y 847
I IF P S + + M +RL + + ++K +D+A KL++ FTA + ++ D +
Sbjct: 809 IVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWF 868
Query: 848 NQCKLVIEEQSGPFIWI 864
K I+ Q G +W+
Sbjct: 869 GSLKDTIQHQQGEAVWV 885
Score = 66.6 bits (161), Expect = 9e-11
Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 91 EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 148
E+ +E +TL++ + G G +++GG DNPH + I I+ ++PGG A DG L+ ND
Sbjct: 26 ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83
Query: 149 CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 187
++ VN + +V HS AV+ L+++G + + V+R R +
Sbjct: 84 RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
Score = 57.4 bits (137), Expect = 6e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 201 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 259
+G G +++GG N H G+ SI ++ ++ GG A DG LQ DR++MVN +E+V H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 260 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 293
AV L+ + +V + V +P + + P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)
Query: 418 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 469
E V L K S G G + GG D GE I +S +L GGPAD G LQ D+++
Sbjct: 30 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87
Query: 470 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 499
VNG + H A L+ +G+ I+ +
Sbjct: 88 VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
Score = 33.9 bits (76), Expect = 0.67
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
+ ++G+S +G +AGG +D GIF+ I G +A ++G L+ D IL+VN D
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
Query: 159 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 192
+ AV L E G +V + + R + ++
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
Score = 30.4 bits (67), Expect = 7.4
Identities = 16/57 (28%), Positives = 31/57 (54%)
Query: 127 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183
IF+ ++ G A +DG L D IL++N +S + A + ++++ ++L V R
Sbjct: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 120 bits (300), Expect = 7e-27
Identities = 114/437 (26%), Positives = 185/437 (42%), Gaps = 85/437 (19%)
Query: 97 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 156
EE+ L SGLGF I GG + G+ + I+PGG A DGRL+ D IL++
Sbjct: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
Query: 157 DVSEVSHSKAVEALKEAGSIVRLYVRRR-------RPILETVVEIKL----FKGP----- 200
+V ++ + + L+ G+ VR+ V R P + + L KGP
Sbjct: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
Query: 201 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 246
+ LG I G VG H + IYV II G AA +G +QV D+++
Sbjct: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
Query: 247 MVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 306
V+ +++ + + V +L+N +VV+L + + T T P PP + P++ L
Sbjct: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
Query: 307 SGNNGTLEYKTSLPPISPGRYSPIPKHM--LVDDDYTRPPEPVYSTVNKLCDKPASPRHY 364
G +E +T++ G I + + L +D+ + KL P SP +
Sbjct: 480 F-LTGAVETETNV----DGEDEEIKERIDTLKNDN--------IQALEKLEKVPDSPENE 526
Query: 365 SPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK--- 421
S + L PD E+ TL ++ + E +K
Sbjct: 527 LK-------------SRWENLLGPDYEVM------------VATLDTQIADDAELQKYSK 561
Query: 422 -VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 480
+ +H G+ + G ++S I++GGP D G LQ D++L VNG+ L G S
Sbjct: 562 LLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSR 617
Query: 481 EQAAAALKGAGQTVTII 497
+A + LK T++
Sbjct: 618 REAVSFLKEVPPPFTLV 634
Score = 108 bits (271), Expect = 2e-23
Identities = 77/220 (35%), Positives = 106/220 (48%), Gaps = 31/220 (14%)
Query: 65 SPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDD 124
+PL PA T P V G E+ E + +G SGLG SI GG D P
Sbjct: 1419 APLSVDPA----------TCPIVPGQEMIIE-----ISKGRSGLGLSIVGGKDTPL---- 1459
Query: 125 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 184
I I ++ GAAA DGRL D IL VN VD+ SH +A+ AL++ VRL V R
Sbjct: 1460 NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
Query: 185 RPILETVVEIKLF------KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 238
+++F K +GLG SI G + ++++ I+ GGAA DGR
Sbjct: 1520 EAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK------RNGSGVFISDIVKGGAADLDGR 1573
Query: 239 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 278
L GD++L VN + + E ILK +V L++G+
Sbjct: 1574 LIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR 1613
Score = 103 bits (258), Expect = 5e-22
Identities = 117/412 (28%), Positives = 169/412 (41%), Gaps = 60/412 (14%)
Query: 95 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154
E I LE+ +GLG S+AG D + IF+ I P G AA DGR+R+ D +L +N
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMS----IFVVGINPEGPAAADGRMRIGDELLEIN 1291
Query: 155 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ 214
+ SH A +K A S V+L R + + + F P SI G +
Sbjct: 1292 NQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMA-VTPFPVPSSSPSSIEDQSGTE 1350
Query: 215 HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL 274
I ++++DG ++VG + L E + + AV+ +K
Sbjct: 1351 PI---------------SSEEDGSVEVGIKQLP------ESESFKLAVSQMKQQKY---- 1385
Query: 275 KVGKPTTIYMTD---PYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIP 331
PT + + P P HS + G L + PI PG+
Sbjct: 1386 ----PTKVSFSSQEIPLAPASSYHSTDADFTGY--GGFQAPLSVDPATCPIVPGQ----- 1434
Query: 332 KHMLVDDDYTRPPEPVYSTVNKLCDKPASPRH--YSPVECDKSFLLSAPYSHYHLGLLPD 389
M+++ R + K A H Y + L A + + D
Sbjct: 1435 -EMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGV-D 1492
Query: 390 SEMTSHSQHSTATRQPSMTLQRAV-----------SLEGEPRKVVLHKGSTGLGFNIVGG 438
+SH + TA RQ ++ V +LE P + K GLG +IVG
Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQ-KKAGRGLGLSIVGK 1551
Query: 439 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 490
+G G+F+S I+ GG ADL G L +GDQILSVNG D+R AS E A LK A
Sbjct: 1552 RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603
Score = 99.0 bits (245), Expect = 2e-20
Identities = 93/325 (28%), Positives = 141/325 (43%), Gaps = 41/325 (12%)
Query: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253
I+L K GLG S+AG + SI+V I G A DGR+++GD LL +NN L
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 254 EEVTHEEAVAILKNTS---EVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 310
+H+ A AI+K ++V+++ P+ P S +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP---------------SSSP 1340
Query: 311 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHY-SPVEC 369
++E ++ PIS V+ + PE S KL + Y + V
Sbjct: 1341 SSIEDQSGTEPISSEEDGS------VEVGIKQLPE---SESFKLAVSQMKQQKYPTKVSF 1391
Query: 370 DKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST 429
+ AP S YH D++ T + T + G+ + + KG +
Sbjct: 1392 SSQEIPLAPASSYHS---TDADFTGYGGFQAPLSVDPATCP---IVPGQEMIIEISKGRS 1445
Query: 430 GLGFNIVGGEDG--EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 487
GLG +IVGG+D I + + G A G L GDQIL VNG+DLR +SHE+A AL
Sbjct: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
Query: 488 KGAGQTVTIIAQYQPEDYARFEAKI 512
+ Q V ++ Y+ E + R E +
Sbjct: 1506 RQTPQKVRLVV-YRDEAHYRDEENL 1529
Score = 88.2 bits (217), Expect = 3e-17
Identities = 69/227 (30%), Positives = 108/227 (47%), Gaps = 41/227 (18%)
Query: 89 GTEIEYEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 147
G +IEY I +ER ++G LGFS+ + ++G IF+ + PG A D RL+ N
Sbjct: 129 GRQIEY----IDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKEN 182
Query: 148 DCILRVNEVDVSE-VSHSKAVEALKEAGSIVRLYVRRR--------------RPILETVV 192
D IL +N + + +SH +A+ L++ +RL V R + ETV
Sbjct: 183 DQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVC 242
Query: 193 -----EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 247
E++L GLGF I GG + + V I+ GG A +DGRLQ GD +L
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 248 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDIT 294
+ +++ +T E+ +L+N V + V + DP G +T
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR-------DPAGDISVT 335
Score = 84.7 bits (208), Expect = 3e-16
Identities = 85/331 (25%), Positives = 139/331 (41%), Gaps = 38/331 (11%)
Query: 186 PILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 245
P E ++EI KG GLG SI GG N+I + ++ + GAA +DGRL GD++
Sbjct: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
Query: 246 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDP---YGPPDITHSYSPPME 302
L VN L +HEEA+ L+ T + V L V + Y + P D+ +
Sbjct: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLG 1545
Query: 303 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD--------DYTRPPEPVYSTVNKL 354
++ NG+ + + I G + + ++ D D + +T+ K
Sbjct: 1546 LSIVGKRNGSGVF---ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKC 1602
Query: 355 CD----------KPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 404
+ S + + +S H P + + Q+ T++
Sbjct: 1603 AQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP---VITGLQNLVGTKR 1659
Query: 405 PSMTLQRAVSLEGEPRKVVLHKG-STGLGFNIVGGEDGE----GIFVSFILAGGPADLSG 459
S Q+ + EPR V +++ S LG +I GG +F++ I A G A +
Sbjct: 1660 VSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
Query: 460 ELQRGDQILSVNGIDLRGASHEQAAAALKGA 490
+L+ GD+I+S+NG L G SH LK A
Sbjct: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 73.2 bits (178), Expect = 1e-12
Identities = 66/235 (28%), Positives = 96/235 (40%), Gaps = 62/235 (26%)
Query: 102 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 161
++ GLG SI G + G+FI+ I+ GGAA DGRL D IL VN D+
Sbjct: 1538 KKAGRGLGLSIVGKRNGS------GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
Query: 162 SHSKAVEALKEAGSIVRLYVRRRR------------------------------PI---L 188
S LK A +V+L + R R P+ L
Sbjct: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
Query: 189 ETVVEIKLFKGPK---------------------GLGFSIAGGVGNQHIPGDNSIYVTKI 227
+ +V K P LG SIAGG G+ GD +++ I
Sbjct: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
Query: 228 IDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI 282
G A + +L+VGDR++ +N L+ ++H + V +LKN + L+V T I
Sbjct: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
Score = 68.2 bits (165), Expect = 3e-11
Identities = 40/108 (37%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 395 HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGP 454
H++ ST++ TL V G +V L +GLGF IVGG+ G+ V I+ GG
Sbjct: 223 HTKSSTSSSLNDTTLPETVCW-GHVEEVELINDGSGLGFGIVGGKTS-GVVVRTIVPGGL 280
Query: 455 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 502
AD G LQ GD IL + G +++G + EQ A L+ G +V ++ P
Sbjct: 281 ADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 64.7 bits (156), Expect = 4e-10
Identities = 37/94 (39%), Positives = 53/94 (56%), Gaps = 11/94 (11%)
Query: 417 GEPRKV-VLHKGSTGLGFNIVGG----------EDGEGIFVSFILAGGPADLSGELQRGD 465
G PR V + + + LG +IVGG E+ +GIF+ +L PA + L+ GD
Sbjct: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
Query: 466 QILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 499
+IL V+G+DL+ ASH +A A+K AG V I Q
Sbjct: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 62.4 bits (150), Expect = 2e-09
Identities = 36/122 (29%), Positives = 62/122 (50%)
Query: 64 ISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGD 123
IS +PA + V T+ + + + + + + + LG I G H G+
Sbjct: 332 ISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGE 391
Query: 124 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183
GI++ IIPG AA +G ++VND I+ V+ V++ ++ VE L+ AG +V L + R
Sbjct: 392 ASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451
Query: 184 RR 185
R+
Sbjct: 452 RK 453
Score = 54.3 bits (129), Expect = 5e-07
Identities = 55/192 (28%), Positives = 80/192 (41%), Gaps = 41/192 (21%)
Query: 128 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR--- 184
+I+ I+ GG G L+ D +L VN + + S +AV LKE L RR
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 185 ------------RPILETVVE------------------------IKLFKGPKGLGFSIA 208
+ ET V+ ++L K KGLGFSI
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
Query: 209 GGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 268
+ P + I + ++ G A++ G L GDRL+ VN Y L+ + EAV ILK
Sbjct: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
Query: 269 SE-VVYLKVGKP 279
+V+L + KP
Sbjct: 761 PPGLVHLGICKP 772
Score = 53.9 bits (128), Expect = 6e-07
Identities = 68/315 (21%), Positives = 113/315 (35%), Gaps = 77/315 (24%)
Query: 194 IKLFKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 245
+++F+ P LG SI GG + + G I++ ++++ A K L+ GD++
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 246 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHL 305
L V+ L+ +H EAV +KN G P + P + +
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKN--------AGNPVVFIVQSLSSTPRVIPNVHNKANKIT 1177
Query: 306 LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPA---SPR 362
+ N T E K +P P + + DD E T K+ + A
Sbjct: 1178 GNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGEL 1237
Query: 363 HYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKV 422
H +E DK+ L +SL G
Sbjct: 1238 HIIELEKDKNGL-------------------------------------GLSLAG----- 1255
Query: 423 VLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 482
+K + + +VG I GPA G ++ GD++L +N L G SH+
Sbjct: 1256 --NKDRSRMSIFVVG-----------INPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
Query: 483 AAAALKGAGQTVTII 497
A+A +K A V ++
Sbjct: 1303 ASAIIKTAPSKVKLV 1317
Score = 53.1 bits (126), Expect = 1e-06
Identities = 45/128 (35%), Positives = 62/128 (48%), Gaps = 10/128 (7%)
Query: 61 QSHISPLKASPAPIIVNTDTL-------DTIPYVNGTEIEYEFEEITLERGNSGLGFSIA 113
QS S S AP+I L D +GT++E EI E ++ LG SIA
Sbjct: 1634 QSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDA-LGISIA 1692
Query: 114 GGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 173
GG +P +GD P +FI I G AA +L+V D I+ +N + +SH+ V LK A
Sbjct: 1693 GGRGSP-LGDIP-VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Query: 174 GSIVRLYV 181
+ L V
Sbjct: 1751 YGRIILQV 1758
Score = 50.1 bits (118), Expect = 9e-06
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 4/82 (4%)
Query: 105 NSGLGFSIAGGTD---NPHIGDD-PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 160
N LG SI GG G++ GIFI +++ A + L+ D IL V+ VD+
Sbjct: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
Query: 161 VSHSKAVEALKEAGSIVRLYVR 182
SHS+AVEA+K AG+ V V+
Sbjct: 1136 ASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 38.5 bits (88), Expect = 0.027
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 430 GLGFNIVGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDL-RGASHEQAA 484
GLGF++V IFV + G AD L+ DQIL++N L + SH+QA
Sbjct: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
Query: 485 AALKGAGQTVTIIAQYQP 502
A L+ ++ +I +P
Sbjct: 204 ALLQQTTGSLRLIVAREP 221
Score = 38.5 bits (88), Expect = 0.027
Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 23/126 (18%)
Query: 418 EPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQILSVNG 472
E + V L K GLGF+I+ +D I + ++A G A+ SG L GD+++SVN
Sbjct: 683 EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
Query: 473 IDLRGASHEQAAAALKGA------------------GQTVTIIAQYQPEDYARFEAKIHD 514
L S +A LK ++ I+ ED F IHD
Sbjct: 743 YCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHD 802
Query: 515 LREQMM 520
+ ++
Sbjct: 803 INSSLI 808
Score = 34.3 bits (77), Expect = 0.52
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 95 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154
E + + L + GLGFSI D P I I ++ G A G L D ++ VN
Sbjct: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Query: 155 EVDVSEVSHSKAVEALK 171
E + S ++AVE LK
Sbjct: 742 EYCLDNTSLAEAVEILK 758
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,084,173
Number of Sequences: 37866
Number of extensions: 1739569
Number of successful extensions: 5726
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 178
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 4389
Number of HSP's gapped (non-prelim): 1073
length of query: 870
length of database: 18,247,518
effective HSP length: 111
effective length of query: 759
effective length of database: 14,044,392
effective search space: 10659693528
effective search space used: 10659693528
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.