Search of human proteins with 87162461

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|87162461 fragile X mental retardation 2 [Homo sapiens]
         (1311 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|87162461 fragile X mental retardation 2 [Homo sapiens]            2647   0.0  
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                   634   0.0  
gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens]        462   e-130
gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens]        447   e-125
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...   331   2e-90
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   83   2e-15
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   83   2e-15
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   82   4e-15
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    82   4e-15
gi|113417084 PREDICTED: hypothetical protein [Homo sapiens]            65   3e-10
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    65   4e-10
gi|239743293 PREDICTED: mucin 12 [Homo sapiens]                        65   4e-10
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...    62   3e-09
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    62   4e-09
gi|169167859 PREDICTED: hypothetical protein, partial [Homo sapi...    62   5e-09
gi|239508976 PREDICTED: mucin 12, cell surface associated [Homo ...    62   5e-09
gi|91982772 mucin 17 [Homo sapiens]                                    61   6e-09
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        61   8e-09
gi|239758058 PREDICTED: similar to mucin, partial [Homo sapiens]       59   3e-08
gi|239749510 PREDICTED: hypothetical protein, partial [Homo sapi...    55   6e-07
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    55   6e-07
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    55   6e-07
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    55   6e-07
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    55   6e-07
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    55   6e-07
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    55   6e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     54   8e-07
gi|239740955 PREDICTED: similar to c114 SLIT-like testicular pro...    54   1e-06
gi|239740953 PREDICTED: similar to c114 SLIT-like testicular pro...    54   1e-06
gi|151301154 mucin 6, gastric [Homo sapiens]                           54   1e-06

>gi|87162461 fragile X mental retardation 2 [Homo sapiens]
          Length = 1311

 Score = 2647 bits (6860), Expect = 0.0
 Identities = 1311/1311 (100%), Positives = 1311/1311 (100%)

Query: 1    MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEY 60
            MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEY
Sbjct: 1    MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEY 60

Query: 61   TNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKN 120
            TNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKN
Sbjct: 61   TNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKN 120

Query: 121  RIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNK 180
            RIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNK
Sbjct: 121  RIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNK 180

Query: 181  MQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPE 240
            MQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPE
Sbjct: 181  MQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPE 240

Query: 241  ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 300
            ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD
Sbjct: 241  ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 300

Query: 301  ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI 360
            ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI
Sbjct: 301  ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI 360

Query: 361  LREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFK 420
            LREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFK
Sbjct: 361  LREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFK 420

Query: 421  SMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQA 480
            SMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQA
Sbjct: 421  SMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQA 480

Query: 481  SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 540
            SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ
Sbjct: 481  SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 540

Query: 541  NKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRP 600
            NKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRP
Sbjct: 541  NKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRP 600

Query: 601  TQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 660
            TQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES
Sbjct: 601  TQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 660

Query: 661  VELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS 720
            VELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS
Sbjct: 661  VELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS 720

Query: 721  NTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSP 780
            NTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSP
Sbjct: 721  NTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSP 780

Query: 781  IPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTA 840
            IPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTA
Sbjct: 781  IPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTA 840

Query: 841  VTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNS 900
            VTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNS
Sbjct: 841  VTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNS 900

Query: 901  SRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGK 960
            SRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGK
Sbjct: 901  SRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGK 960

Query: 961  FCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTT 1020
            FCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTT
Sbjct: 961  FCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTT 1020

Query: 1021 TTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAK 1080
            TTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAK
Sbjct: 1021 TTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAK 1080

Query: 1081 KLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRL 1140
            KLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRL
Sbjct: 1081 KLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRL 1140

Query: 1141 KNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIP 1200
            KNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIP
Sbjct: 1141 KNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIP 1200

Query: 1201 SPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHW 1260
            SPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHW
Sbjct: 1201 SPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHW 1260

Query: 1261 DMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL 1311
            DMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL
Sbjct: 1261 DMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL 1311


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score =  634 bits (1634), Expect = 0.0
 Identities = 484/1319 (36%), Positives = 681/1319 (51%), Gaps = 187/1319 (14%)

Query: 20   QDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEYTNKGDALANRVQNTLGNYD 79
            +DR+ L+ +E ERRNQE+QQ +D F     LF EPYKV   T+K D L++R+Q+ LGNYD
Sbjct: 4    EDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKV---TSKEDKLSSRIQSMLGNYD 60

Query: 80   EMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIPPHQDNTH-PSAPMPP 138
            EMK+ + + S    LV IPK +VP + + K+ P+FF ++       HQ +   P  P P 
Sbjct: 61   EMKDFIGDRSIPK-LVAIPKPTVPPSADEKSNPNFFEQRHGG---SHQSSKWTPVGPAPS 116

Query: 139  PSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFV 198
             S     S+ + S   S+    R S   S+   + +SGQ +  ++     S ++ +    
Sbjct: 117  TSQSQKRSSGLQSGHSSQ----RTSAGSSS--GTNSSGQRHDRESYNNSGSSSRKKG--Q 168

Query: 199  YPAEQPQIGEVEESNP---SAKEDSNPNSSGEDAF-KEIFQSNSPEESEFAVQAPGSPLV 254
            + +E  +        P   S+   S+  S G D   KE  +S SP + +    +P     
Sbjct: 169  HGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSP----- 223

Query: 255  ASSLLAPSSGL-SVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFEN 313
              S +  SSG  S Q+FPP L  K++   QKPTAYVRPMDGQ+    + P L        
Sbjct: 224  --SRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQES---MEPKLSSEHYSSQ 278

Query: 314  SFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLT 373
            S GN    ++ + KPS+ +  TKL   +  Q  + S   D SCV+EIL+EMTHSWP PLT
Sbjct: 279  SHGN----SMTELKPSSKAHLTKLKIPS--QPLDASASGDVSCVDEILKEMTHSWPPPLT 332

Query: 374  SMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDE 433
            ++HT   +E S F  P +ESQ    G   QK  +P+   ++     KSML+DDLKLSS E
Sbjct: 333  AIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSK--TSNGHQSKSMLKDDLKLSSSE 390

Query: 434  DDLEPVKTLTTQCTATELYQAVEKAKPRNNP-VNPPLATPQPPPAVQASGGSGSSSESES 492
            D              ++  Q  +K  PR+ P  N   +      A  +   S S S SES
Sbjct: 391  D--------------SDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSES 436

Query: 493  SSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETP 552
            SS SDS++ESS++DSE+NE  + A+PEPEPP TNKWQLD WLNKV     S        P
Sbjct: 437  SSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVS--------P 488

Query: 553  METISLPPPIIQPMEVQMKVKT--NASQVPAEPKERPLLSLIREKARPRPTQKIPETKAL 610
              ++    P  Q  + + + +   N+    + PKE    +  R+    +  QK  E+   
Sbjct: 489  ASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDS---KTIQKGSESGRG 545

Query: 611  KHKLSTTSETVSQR-TIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRG 669
            + K    S++ +QR T+GKKQPKK EK  + +     K  I S TP +  S      P  
Sbjct: 546  RQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLK--IESETPVDLAS----SMPSS 599

Query: 670  RNKAT---AHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEE 726
            R+KA    + KP  +KE + +     EKKKY+   K   KSRE IETD+S+SDS  D+ E
Sbjct: 600  RHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDS--DESE 657

Query: 727  TLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSP---IPV 783
            +L     PP       T K  E            S+       S+  E+  F      P+
Sbjct: 658  SL-----PP----SSQTPKYPE------------SNRTPVKPSSVEEEDSFFRQRMFSPM 696

Query: 784  MQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTA 843
             + E+LSPL + ++   L VKIDL+LL+R+PG       P K + K    K  R+    A
Sbjct: 697  EEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQA 756

Query: 844  VEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRR 903
             EK + KGKRKHK  +       KK + E+  +             HKP + RE++    
Sbjct: 757  SEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSA-----------GHKPSSNRESSKQSA 805

Query: 904  ANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCA 963
            A   KE+ L P P  P+P   P+  + S       + + I+ +  + S+     E     
Sbjct: 806  A---KEKDLLPSPAGPVPSKDPKTEHGS-------RKRTISQSSSLKSSSNSNKETS--- 852

Query: 964  TFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTI 1023
               G S N   T K+                T   T+  +  V   A ++++    +   
Sbjct: 853  ---GSSKNSSSTSKQKK--------------TEGKTSSSSKEVKEKAPSSSSNCPPSA-- 893

Query: 1024 STITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLK 1083
                                     P L SS    RR KL FDD  ++AD+Y+QEAKKLK
Sbjct: 894  -------------------------PTLDSSKP--RRTKLVFDDRNYSADHYLQEAKKLK 926

Query: 1084 HKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNF 1143
            H ADAL ++F KAV Y DA +SF ECGNA+E++  E+KSP+ MYSETV+L++Y M+LKN+
Sbjct: 927  HNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSETVDLIKYTMKLKNY 986

Query: 1144 ASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPW 1203
             +P A+  DK+L VLC RC SLLYLR+FKLKK++A+KYS++L E+ K N+   +Q PSP 
Sbjct: 987  LAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLK-NSYNNSQAPSPG 1045

Query: 1204 V-SNGKNTPSPVSLNNVSPINAMGNCNNG---------PVTIPQRIHHMAASHVNITSNV 1253
            + S     PSPVS   +SP N+ GN ++G          VTIPQ+IH MAAS+V +TSN 
Sbjct: 1046 LGSKAVGMPSPVS-PKLSPGNS-GNYSSGASSASASGSSVTIPQKIHQMAASYVQVTSNF 1103

Query: 1254 LRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSS-MTNLVRYVRQGLCWLRIDAHLL 1311
            L   E WD A++L++E KEFF +LD +MGPL  ++S MT+LVRY RQGL WLR DA L+
Sbjct: 1104 LYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLVRYTRQGLHWLRQDAKLI 1162


>gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens]
          Length = 1226

 Score =  462 bits (1190), Expect = e-130
 Identities = 334/995 (33%), Positives = 486/995 (48%), Gaps = 117/995 (11%)

Query: 1   MDLFDF--FRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVA 58
           MD FD    ++WDLE  C YE DR+AL+++E ERRNQE QQ+D  F+S + LF EPYK  
Sbjct: 1   MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYK-- 58

Query: 59  EYTNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQ 118
             TNKGD L+NR+QNTLGNYDEMK+ LT+ SNQ+HLVG+PK  VPQ P NK +  F  + 
Sbjct: 59  --TNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADS 116

Query: 119 KNRIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQP 178
           + +  P    +T  S P   P         +  +++    W +  H PS     Q + Q 
Sbjct: 117 RAQNQPSSICSTTTSTPAAVP---------VQQSKRGTMGWQKAGHPPSD--GQQRATQQ 165

Query: 179 NKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNS 238
             ++TL  D                     V    P AK+  N                 
Sbjct: 166 GSLRTLLGDG--------------------VGRQQPRAKQVCNV---------------- 189

Query: 239 PEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQA 298
               E  +Q    P  A +    SSG  VQNFPP L  K S+ QQKPTAYVRPMDGQDQA
Sbjct: 190 ----EVGLQTQERP-PAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQA 244

Query: 299 PDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDP-SCV 357
           PD SP LK S E   S    S+  +   KP  A +K KL KF+I +  E S   +  SCV
Sbjct: 245 PDESPKLKSSSE--TSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCV 302

Query: 358 EEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSV 417
           EEI+REMT  W  PL+++   G  E + F  P ++SQ ++ G    K  D    +     
Sbjct: 303 EEIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGT 360

Query: 418 SFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPA 477
           S  SMLEDDLKLSSDE++ E      T   A      V++   R +     + + +   +
Sbjct: 361 SNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTS-----VPSSKGSSS 415

Query: 478 VQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKV 537
             +SG S SSS+SESSS SDS+TESS+++SE ++ P  ++PE EP S+NKWQLDKWLNKV
Sbjct: 416 SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKV 475

Query: 538 TSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVP--AEP--KERPLLSLIR 593
                  +        E+     P+ + ++       +  +VP   +P  +E+ + S  +
Sbjct: 476 NPHKPPILIQNESHGSESNQYYNPVKEDVQ-------DCGKVPDVCQPSLREKEIKSTCK 528

Query: 594 EKARPRPTQKIPETKALKHKLSTTSETV----------------------SQRTIGKKQP 631
           E+ RPR   K P +K +K K    +  V                      ++R+ GKK  
Sbjct: 529 EEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPT 588

Query: 632 KKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLA 691
           ++ E+ ++ D     +P   ++      SV +   P        ++ + RKE R ++   
Sbjct: 589 RRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTC- 647

Query: 692 PEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLP-------PCIISGGNTA 744
            EK++ RG  +IVPKS+EFIET+SS+S S++D +   + +  P           S GN  
Sbjct: 648 -EKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQ 706

Query: 745 KSKEIC---GASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNL 801
           + KE     G+         ++ + ++++   EE  ++ +P  + E+LSPL+D + +++L
Sbjct: 707 RLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSL 766

Query: 802 WVKIDLDLLSRVPGHSSLH-AAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEV 860
           WVKIDL LLSR+P H        + P  K++ + P   T+ T  EK  PK KRK K    
Sbjct: 767 WVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNE 826

Query: 861 AEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPL 920
            +    KK + E+ ++  L     S +      +   N +S      K EK+   P+SPL
Sbjct: 827 DDYREIKKSQGEKDSSSRL---ATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPL 883

Query: 921 PEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPK 955
            +    +            + N   T   +S KPK
Sbjct: 884 SDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPK 918



 Score =  332 bits (852), Expect = 1e-90
 Identities = 164/270 (60%), Positives = 213/270 (78%), Gaps = 12/270 (4%)

Query: 1052 SSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGN 1111
            S+   + +R KL FDD   +ADY+MQEAK++KHKADA+ EKFGKA+NYA+AALSF ECGN
Sbjct: 957  SNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGN 1016

Query: 1112 AMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMF 1171
            AME+ P+E+KSPYTMYSETVEL+RYAMRLK  + P A+  DK+LA LCYRCL+LLY RMF
Sbjct: 1017 AMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMF 1076

Query: 1172 KLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKN--TPSPVSLN--NVSPINAMGN 1227
            +LK+DHA+KYS++L++YFK N+SK AQ PSPW ++GK+  TPSP+S N    S + + G+
Sbjct: 1077 RLKRDHAVKYSKALIDYFK-NSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGS 1135

Query: 1228 CNNGP-------VTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTL 1280
             +N         V+IPQRIH MAA+HV+IT+++L  Y++W+MAD L +EN+EFF DLD L
Sbjct: 1136 LSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLL 1195

Query: 1281 MGPLTQHSSMTNLVRYVRQGLCWLRIDAHL 1310
            MGP+T HSSM +LV+Y +QGL WLR  AHL
Sbjct: 1196 MGPVTLHSSMEHLVQYSQQGLHWLRNSAHL 1225


>gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens]
          Length = 1251

 Score =  447 bits (1149), Expect = e-125
 Identities = 325/976 (33%), Positives = 475/976 (48%), Gaps = 115/976 (11%)

Query: 18  YEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEYTNKGDALANRVQNTLGN 77
           YE DR+AL+++E ERRNQE QQ+D  F+S + LF EPYK    TNKGD L+NR+QNTLGN
Sbjct: 45  YEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYK----TNKGDELSNRIQNTLGN 100

Query: 78  YDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIPPHQDNTHPSAPMP 137
           YDEMK+ LT+ SNQ+HLVG+PK  VPQ P NK +  F  + + +  P    +T  S P  
Sbjct: 101 YDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAA 160

Query: 138 PPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFF 197
            P         +  +++    W +  H PS     Q + Q   ++TL  D          
Sbjct: 161 VP---------VQQSKRGTMGWQKAGHPPSD--GQQRATQQGSLRTLLGDG--------- 200

Query: 198 VYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASS 257
                      V    P AK+  N                     E  +Q    P  A +
Sbjct: 201 -----------VGRQQPRAKQVCNV--------------------EVGLQTQERP-PAMA 228

Query: 258 LLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGN 317
               SSG  VQNFPP L  K S+ QQKPTAYVRPMDGQDQAPD SP LK S E   S   
Sbjct: 229 AKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSE--TSVHC 286

Query: 318 LSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDP-SCVEEILREMTHSWPTPLTSMH 376
            S+  +   KP  A +K KL KF+I +  E S   +  SCVEEI+REMT  W  PL+++ 
Sbjct: 287 TSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMT--WLPPLSAIQ 344

Query: 377 TAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDL 436
             G  E + F  P ++SQ ++ G    K  D    +     S  SMLEDDLKLSSDE++ 
Sbjct: 345 APGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEEN 404

Query: 437 EPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSES 496
           E      T   A      V++   R +     + + +   +  +SG S SSS+SESSS S
Sbjct: 405 EQQAAQRTALRALSDSAVVQQPNCRTS-----VPSSKGSSSSSSSGSSSSSSDSESSSGS 459

Query: 497 DSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETI 556
           DS+TESS+++SE ++ P  ++PE EP S+NKWQLDKWLNKV       +        E+ 
Sbjct: 460 DSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESN 519

Query: 557 SLPPPIIQPMEVQMKVKTNASQVP--AEP--KERPLLSLIREKARPRPTQKIPETKALKH 612
               P+ + ++       +  +VP   +P  +E+ + S  +E+ RPR   K P +K +K 
Sbjct: 520 QYYNPVKEDVQ-------DCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQ 572

Query: 613 KLSTTSETV----------------------SQRTIGKKQPKKVEKNTSTDEFTWPKPNI 650
           K    +  V                      ++R+ GKK  ++ E+ ++ D     +P  
Sbjct: 573 KSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEE 632

Query: 651 TSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREF 710
            ++      SV +   P        ++ + RKE R ++    EK++ RG  +IVPKS+EF
Sbjct: 633 PAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTC--EKRRTRGLSRIVPKSKEF 690

Query: 711 IETDSSTSDSNTDQEETLQIKVLP-------PCIISGGNTAKSKEIC---GASLTLSTLM 760
           IET+SS+S S++D +   + +  P           S GN  + KE     G+        
Sbjct: 691 IETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGS 750

Query: 761 SSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLH 820
            ++ + ++++   EE  ++ +P  + E+LSPL+D + +++LWVKIDL LLSR+P H    
Sbjct: 751 INARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQE 810

Query: 821 -AAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICL 879
               + P  K++ + P   T+ T  EK  PK KRK K     +    KK + E+ ++  L
Sbjct: 811 PGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRL 870

Query: 880 LPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQ 939
                S +      +   N +S      K EK+   P+SPL +    +            
Sbjct: 871 ---ATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRP 927

Query: 940 DKNIAMTGQITSTKPK 955
           + N   T   +S KPK
Sbjct: 928 NGNSLFTSASSSKKPK 943



 Score =  332 bits (852), Expect = 1e-90
 Identities = 164/270 (60%), Positives = 213/270 (78%), Gaps = 12/270 (4%)

Query: 1052 SSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGN 1111
            S+   + +R KL FDD   +ADY+MQEAK++KHKADA+ EKFGKA+NYA+AALSF ECGN
Sbjct: 982  SNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGN 1041

Query: 1112 AMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMF 1171
            AME+ P+E+KSPYTMYSETVEL+RYAMRLK  + P A+  DK+LA LCYRCL+LLY RMF
Sbjct: 1042 AMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMF 1101

Query: 1172 KLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKN--TPSPVSLN--NVSPINAMGN 1227
            +LK+DHA+KYS++L++YFK N+SK AQ PSPW ++GK+  TPSP+S N    S + + G+
Sbjct: 1102 RLKRDHAVKYSKALIDYFK-NSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGS 1160

Query: 1228 CNNGP-------VTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTL 1280
             +N         V+IPQRIH MAA+HV+IT+++L  Y++W+MAD L +EN+EFF DLD L
Sbjct: 1161 LSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLL 1220

Query: 1281 MGPLTQHSSMTNLVRYVRQGLCWLRIDAHL 1310
            MGP+T HSSM +LV+Y +QGL WLR  AHL
Sbjct: 1221 MGPVTLHSSMEHLVQYSQQGLHWLRNSAHL 1250


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score =  331 bits (849), Expect = 2e-90
 Identities = 300/1012 (29%), Positives = 447/1012 (44%), Gaps = 129/1012 (12%)

Query: 14  QQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEYTNKGDALANRVQN 73
           Q   Y  DR+ L+ RE ERRNQE  QE + F     LFGEPYK A    KGD L++R+QN
Sbjct: 4   QSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTA----KGDELSSRIQN 59

Query: 74  TLGNYDEMKNLLTNHSNQNHLVGIPKNSV--PQNPNNKNEPSFFPEQKNRIIPPHQDNTH 131
            LGNY+E+K  L+  S+  H +   +N +  P+ P   ++ S  P         HQ    
Sbjct: 60  MLGNYEEVKEFLSTKSH-THRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHT 118

Query: 132 PSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQ--- 188
           P++   P SV          N    P+ ++    P   L +++ G P+  Q LTQD+   
Sbjct: 119 PASG--PLSV---------GNISHNPKMAQPRTEPMPSLHAKSCGPPDS-QHLTQDRLGQ 166

Query: 189 ---------------------------SQAKLEDFFVYPAEQPQIGEV---EESNPSAKE 218
                                       + +L      P+  P +  +   +++ P  + 
Sbjct: 167 EGFGSSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQG 226

Query: 219 DSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKT 278
            S  + S  ++ K    + SP++    V    +P    SL+AP+   S    PP L  K+
Sbjct: 227 SSKVHGSSNNS-KGYCPAKSPKDLAVKVHDKETP--QDSLVAPAQPPSQTFPPPSLPSKS 283

Query: 279 SMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFG-TLLDGKPSAASSKTKL 337
              QQKPTAYVRPMDGQDQAP  SP LKP  E    +   +F  T L     A  +K K+
Sbjct: 284 VAMQQKPTAYVRPMDGQDQAPSESPELKPLPE---DYRQQTFEKTDLKVPAKAKLTKLKM 340

Query: 338 PKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLT 397
           P  ++ QT      ++  CVEEIL+EMTHSWP PLT++HT   +E S F  P ++SQH++
Sbjct: 341 PSQSVEQTYS----NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVS 396

Query: 398 PGFTLQKWNDPTTRASTKSVS-FKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVE 456
                QK  D +++  + S     SMLEDDL+LS  ED              ++  Q  E
Sbjct: 397 SVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED--------------SDSEQTPE 442

Query: 457 KAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVA 516
           K    + P + P + P+P  +  +S    S S S+S S SDS++ESS++DSE NE     
Sbjct: 443 KPPSSSAPPSAPQSLPEPVASAHSSSAE-SESTSDSDSSSDSESESSSSDSEENEPLETP 501

Query: 517 TPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNA 576
            PEPEPP+TNKWQLD WL KV+           E P  T    PP   P E +    +  
Sbjct: 502 APEPEPPTTNKWQLDNWLTKVSQP-----AAPPEGPRST---EPPRRHP-ESKGSSDSAT 552

Query: 577 SQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEK 636
           SQ  +E K+ P  S    KA   P +     K    K     E   ++T+G KQPKK  K
Sbjct: 553 SQEHSESKDPPPKS--SSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVK 610

Query: 637 -----NTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLA 691
                 + T      +P +     +++ S    D P+ + K    + A   EP+P +P +
Sbjct: 611 ASARAGSRTSLQGEREPGLLPYGSRDQTS---KDKPKVKTKGRP-RAAASNEPKPAVPPS 666

Query: 692 PEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG 751
            EKKK++     +P   + +       D+  D+  T +   L P   S G          
Sbjct: 667 SEKKKHKSS---LPAPSKALSGPEPAKDNVEDR--TPEHFALVPLTESQGPPHSGSGSRT 721

Query: 752 ASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLS 811
           +    + ++      + L          P+P+  T++LSPLRD    ++L VKI LDLLS
Sbjct: 722 SGCRQAVVVQEDSRKDRL----------PLPLRDTKLLSPLRDTPPPQSLMVKITLDLLS 771

Query: 812 RVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRL 871
           R+P      +   K + K+     K  +   + +  +   K++    E       KK RL
Sbjct: 772 RIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKG--EAERDCDNKKIRL 829

Query: 872 EEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPP------ 925
           E+     +     S +  HK  +++   S   +   K+E L PPP+S   + P       
Sbjct: 830 EKE----IKSQSSSSSSSHK-ESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR 884

Query: 926 --RRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDT 975
             R  +  G + P       +     +  K +R EGK   +      + GDT
Sbjct: 885 SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDT 936



 Score =  206 bits (523), Expect = 2e-52
 Identities = 244/989 (24%), Positives = 403/989 (40%), Gaps = 97/989 (9%)

Query: 366  HSWPTPLTSMHTAGHSEQSTF---SIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSM 422
            H   TP  S+         TF   S+P +            +  D   +A ++S   K +
Sbjct: 254  HDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPL 313

Query: 423  LEDDLKLSSDEDDLE-PVKTLTT----------QCTATELYQAVEKAKPRNNPVNPPLAT 471
             ED  + + ++ DL+ P K   T          Q  + E++   E  K   +   PPL  
Sbjct: 314  PEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTA 373

Query: 472  PQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLD 531
               P   + S     + +S+  S    + +   T S+++   +  T        +  QL 
Sbjct: 374  IHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSM---LEDDLQLS 430

Query: 532  KWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSL 591
               +  + Q        +  P    SLP P+        + ++ +    +   E    S 
Sbjct: 431  DSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSS 490

Query: 592  IREKARP----RPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPK 647
              E+  P     P  + P T   K +L      VSQ     + P+  E      E     
Sbjct: 491  DSEENEPLETPAPEPEPPTTN--KWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSS 548

Query: 648  PNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKS 707
             + TS    E +      PP+  +KA     AP + P P      ++   + P +  P  
Sbjct: 549  DSATSQEHSESKD----PPPKSSSKAPR---APPEAPHPG-----KRSCQKSPAQQEPPQ 596

Query: 708  REFIETD--------SSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTL 759
            R+ + T         S+ + S T  +   +  +LP    S   T+K K            
Sbjct: 597  RQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLP--YGSRDQTSKDKPKVKTKGRPRAA 654

Query: 760  MSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSL 819
             S+         S ++   S +P     +  P    +N+++           R P H +L
Sbjct: 655  ASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVED-----------RTPEHFAL 703

Query: 820  HAAPAK--PDHKETATKPKRQTAVTAVEKPAPKGK-----RKHKPIEVAEKIPEKKQRLE 872
                    P H  + ++         V++ + K +     R  K +      P   Q L 
Sbjct: 704  VPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPP-QSLM 762

Query: 873  EATTICLLPPCISPAPPHKPPNTR--ENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNV 930
               T+ LL     P PP K    R  E+       +   EK      S L +        
Sbjct: 763  VKITLDLLSRI--PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAER 820

Query: 931  SGNNGPFGQDKNIAMTGQITSTKPKRT-EGKFCATFKGISVNEGDTPKKASSATITVTNT 989
              +N     +K I      +S+  K + + K        S  E   P   SS++      
Sbjct: 821  DCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKP 880

Query: 990  AIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITT---GLMDSSHLEMTSWA 1046
            A+  +   A      T       +A++T +    S+I         G   SS  + +S  
Sbjct: 881  ALKRSRREAD-----TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGD 935

Query: 1047 A-----LPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYAD 1101
                  +P L + ++   +P++ FD     AD +M+EAKK+K KA+ + ++ GKA  Y +
Sbjct: 936  TANPFPVPSLPNGNSKPGKPQVKFDKQ--QADLHMREAKKMKQKAELMTDRVGKAFKYLE 993

Query: 1102 AALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYR 1161
            A LSF ECG A E +   +KS Y++YSETV+L+++ M LK+F+   A   +K  AVLC R
Sbjct: 994  AVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMR 1053

Query: 1162 CLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSP 1221
            C S+L + MF+ KKD A+KYSR+L ++F +++SKVAQ PSP +++   TPSP+S    SP
Sbjct: 1054 CQSILNMAMFRCKKDIAIKYSRTLNKHF-ESSSKVAQAPSPCIAS-TGTPSPLS-PMPSP 1110

Query: 1222 INAMGNCNN----------GPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENK 1271
             +++G+ ++            ++ P  I +M +S+V ITS+VL  ++ W+ A+ LTR+NK
Sbjct: 1111 ASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNK 1170

Query: 1272 EFFGDLDTLMGPLTQHSSMTNLVRYVRQG 1300
            EFF  L T +  L  +SS+ +LV Y RQG
Sbjct: 1171 EFFARLSTNVCTLALNSSLVDLVHYTRQG 1199


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 152/753 (20%), Positives = 234/753 (31%), Gaps = 77/753 (10%)

Query: 284  KPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSA----ASSKTKLPK 339
            K T  +     +D AP      KP+ + E +    +  T  +  P+     AS+  K P 
Sbjct: 174  KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233

Query: 340  FTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPG 399
             T ++++  + P +P+         T   P P T+   A  + +              P 
Sbjct: 234  PTTIKSAPTT-PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKE-------------PA 279

Query: 400  FTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAK 459
             T  K   PTT  S  +   K       K  +     EP  T   + T T   +     K
Sbjct: 280  PTTTKEPAPTTTKSAPTTP-KEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTK 338

Query: 460  PRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPE 519
                    P  T    PA  A      ++  E +  +  +   +TT     + P   TP+
Sbjct: 339  E-------PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT-----KEPSPTTPK 386

Query: 520  PEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQV 579
               P+T K           +  KS      E    T   P P           K  A   
Sbjct: 387  EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTT 446

Query: 580  PAEPK----ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVE 635
            P EP     + P  +  ++ A   P +  P T   K    TT + ++  T  K  P   E
Sbjct: 447  PKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTP--KETAPTTPKKLTPTTPEKLAPTTPE 504

Query: 636  KNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKK 695
            K   T         +  +TP+E       +P     KA A  P   KEP P  P  P   
Sbjct: 505  KPAPTTP-----EELAPTTPEEPTPTTPEEPAPTTPKAAA--PNTPKEPAPTTPKEPAPT 557

Query: 696  KYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG--AS 753
              + P    PK         +   +  +   T   K  P  +        +   C   A 
Sbjct: 558  TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 617

Query: 754  LTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV 813
             T      ++      +   E    +P     T +  P                      
Sbjct: 618  TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP---------------------- 655

Query: 814  PGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEE 873
                     P KP  KE A    +    T  +KPAP   ++  P    E  P   ++   
Sbjct: 656  -----APTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK-PA 709

Query: 874  ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN 933
             TT    PP  S      P  T+E  +  ++      +L   P     E+ P+   V   
Sbjct: 710  PTTPETPPPTTSEV--STPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTT 767

Query: 934  NGPFGQDKNIAMTGQ-ITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIA 992
              P      +  T +  T+ +  RT  +       ++     T +K + + IT T T + 
Sbjct: 768  KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVT 827

Query: 993  TATVTATAIVTTTVTATATATATTTTTTTTIST 1025
            + T   T     T   T T     TTT  TI+T
Sbjct: 828  STTTQDTTPFKITTLKTTTLAPKVTTTKKTITT 860



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 139/600 (23%), Positives = 205/600 (34%), Gaps = 64/600 (10%)

Query: 458  AKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVAT 517
            A+ ++N  N     P P P V    GSG  +     +  D+   S+T  ++ + +P++ T
Sbjct: 64   AEVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDT---STTQHNKVSTSPKITT 120

Query: 518  PEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNAS 577
             +P  P  +        N  TS+  S    + ET +ET        Q      +  T+A 
Sbjct: 121  AKPINPRPSLPP-----NSDTSKETSLTVNK-ETTVETKETTTTNKQTSTDGKEKTTSAK 174

Query: 578  QVPAEPK--ERPLLSLIREKARPRP------------TQKIPETKALKHKLSTTSETVSQ 623
            +  +  K   + L    +  A+P P            T K P     K   STT +  + 
Sbjct: 175  ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTP 234

Query: 624  RTI--GKKQPKKVEKNTSTDEFTWPK---PNITS----STPKEKESVELHDPPRGRNKA- 673
             TI      PK+    T+    T PK   P  T     +TPKE       +P     K+ 
Sbjct: 235  TTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSA 294

Query: 674  --TAHKPAPR--KEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQ 729
              T  +PAP   K+P P  P  P     + P    PK        ++   + T  +E   
Sbjct: 295  PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKE----PAPTTKEPAPTTPKEPAP 350

Query: 730  IKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEIL 789
                 P   +    A +     A  T      ++      + +   PT +  P   T   
Sbjct: 351  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 410

Query: 790  SPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAP 849
            +P    E       K       + P  ++    PA    KE A    ++ A T  +KPAP
Sbjct: 411  APTTPKEPSPTT-TKEPAPTTPKEPAPTT-PKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 468

Query: 850  KGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKP-PNTRENNSSRRANRRK 908
               ++  P    E  P   ++L   T     P  ++P  P KP P T E      A    
Sbjct: 469  TTPKEPAPTTPKETAPTTPKKLTPTT-----PEKLAPTTPEKPAPTTPE----ELAPTTP 519

Query: 909  EEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMT--GQITSTKPKRT-----EGKF 961
            EE     P  P P  P      +         K  A T   +   T PK T     +G  
Sbjct: 520  EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA 579

Query: 962  CATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTT 1021
              T K  +     TPKK +   +  T T   T+T T      TT   TA  T      TT
Sbjct: 580  PTTLKEPAPT---TPKKPAPKELAPTTTKEPTST-TCDKPAPTTPKGTAPTTPKEPAPTT 635



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 131/628 (20%), Positives = 197/628 (31%), Gaps = 71/628 (11%)

Query: 464  PVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPP 523
            P  P   TP+ P          +  E   ++   + T        + + P   TP+   P
Sbjct: 221  PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 280

Query: 524  STNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEV-----QMKVKTNASQ 578
            +T K           +  K       + P  T    P    P E      +    T    
Sbjct: 281  TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 340

Query: 579  VPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNT 638
             P  PKE P  +  ++ A   P +  P T   K    TT++  S  T   K+P      +
Sbjct: 341  APTTPKE-PAPTAPKKPAPTTPKEPAPTTP--KEPAPTTTKEPSPTT--PKEPAPTTTKS 395

Query: 639  STDEFTWPKPNITSS---TPKEKESVELHDP----PRGRNKATAHKPAPR--KEPRPNIP 689
            +      P P  T S   TPKE       +P    P+     T  KPAP   KEP P  P
Sbjct: 396  APTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 455

Query: 690  LAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEI 749
              P     + P    PK        + T+   T      ++    P  ++     K    
Sbjct: 456  KEPAPTTTKKPAPTTPKE------PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPT 509

Query: 750  CGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDL 809
                L  +T               EEPT  P    +    +P     N      K     
Sbjct: 510  TPEELAPTT--------------PEEPT--PTTPEEPAPTTPKAAAPNTP----KEPAPT 549

Query: 810  LSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQ 869
              + P  ++    PA    KETA    + TA T +++PAP   +K  P E+A    +   
Sbjct: 550  TPKEPAPTT-PKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK--- 605

Query: 870  RLEEATTIC-----LLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDP 924
              E  +T C       P   +P  P +P  T     +    +         P    P+ P
Sbjct: 606  --EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 663

Query: 925  -PRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSAT 983
             P+    +   GP     +         T P   +     T K  +    +TP   +S  
Sbjct: 664  APKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEV 723

Query: 984  ITVTNTAIATATVTATAIVTTTVTATATATATTTT-------TTTTISTITSTITTGLMD 1036
             T T T   T    +    T  ++A  T  A   +       TT T +     +TT   D
Sbjct: 724  STPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD 783

Query: 1037 SSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
             +           L ++  T    PK+T
Sbjct: 784  KT-------TERDLRTTPETTTAAPKMT 804



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 87/409 (21%), Positives = 149/409 (36%), Gaps = 27/409 (6%)

Query: 341 TILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTP-- 398
           T L+    + P  P+  E  L   T   PT  T    A  + + T     +E    TP  
Sbjct: 581 TTLKEPAPTTPKKPAPKE--LAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 638

Query: 399 -GFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEK 457
              T  K   PTT       + K     +L  ++ +             T  E      K
Sbjct: 639 PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 698

Query: 458 AKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRV-- 515
                 P  P   TP+ PP   +   + ++++  ++     D   ST +  +   P+   
Sbjct: 699 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALE 756

Query: 516 -ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT 574
            +  EP  P+T      K     T+++K+       TP ET +  P + +      + KT
Sbjct: 757 NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP-ETTTAAPKMTKETATTTE-KT 814

Query: 575 NASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKK--QPK 632
             S++ A   +  + S   +   P     + +T  L  K++TT +T++   I  K  +  
Sbjct: 815 TESKITATTTQ--VTSTTTQDTTPFKITTL-KTTTLAPKVTTTKKTITTTEIMNKPEETA 871

Query: 633 KVEKNTSTDEFTWPKPNITSSTPKEKESVEL-HDPPRGRNKATAHKPAPRK------EPR 685
           K +   +  + T PKP   +  PK+  S +     PR R   T   P PRK      E  
Sbjct: 872 KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT--PTPRKMTSTMPELN 929

Query: 686 PNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLP 734
           P   +A    +        P S+  +E +  + D+   + ET  + + P
Sbjct: 930 PTSRIAEAMLQTTTRPNQTPNSK-LVEVNPKSEDAGGAEGETPHMLLRP 977



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 116/551 (21%), Positives = 179/551 (32%), Gaps = 61/551 (11%)

Query: 330 AASSKTKLPKFTILQTSEVSLPSDPS-CVEEILREMTHSWPTPLTSMHTAGHSEQSTFSI 388
           +A + TK P  T  +++  + P +PS    +     T   P P T    A  + +     
Sbjct: 395 SAPTTTKEPAPTTTKSAPTT-PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 453

Query: 389 PGQESQHLT---PGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLT-- 443
             +E    T   P  T  K   PTT   T   + K +     +  +     +P  T    
Sbjct: 454 TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 513

Query: 444 ---------TQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSS 494
                    T  T  E      KA   N P  P   TP+ P A         ++  E++ 
Sbjct: 514 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP-APTTPKEPAPTTPKETAP 572

Query: 495 ESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKV--TSQNKSFICGQNETP 552
            +   T  +T    +   P+   P+   P+T K       +K   T+   +      E  
Sbjct: 573 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 632

Query: 553 METISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKH 612
             T   P P          +K  A   P +P  + L            T K P +     
Sbjct: 633 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT---------TTKGPTSTTSDK 683

Query: 613 KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKE-KESVELHDPPRGRN 671
              TT +  +  T  +  P   +K   T   T P      STP   KE   +H  P    
Sbjct: 684 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 743

Query: 672 KATAHKPAPRK-EPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQI 730
              + +P P+  E  P  P  P  K    P    P+     +  ++  D  T  E T   
Sbjct: 744 PELSAEPTPKALENSPKEPGVPTTKT---PAATKPEMTTTAKDKTTERDLRTTPETTTAA 800

Query: 731 -KVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEIL 789
            K+      +   T +SK      +T +T   +S        + ++ T   I  ++T  L
Sbjct: 801 PKMTKETATTTEKTTESK------ITATTTQVTS-------TTTQDTTPFKITTLKTTTL 847

Query: 790 SPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKET---ATKPKRQTAVTAVEK 846
           +P      +      I    +   P  +      AKP  + T   AT PK Q    A +K
Sbjct: 848 AP-----KVTTTKKTITTTEIMNKPEET------AKPKDRATNSKATTPKPQKPTKAPKK 896

Query: 847 PAPKGKRKHKP 857
           P    K K  P
Sbjct: 897 PTSTKKPKTMP 907



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 32/125 (25%), Positives = 49/125 (39%), Gaps = 12/125 (9%)

Query: 916  PLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDT 975
            P++P P  PP        +    ++  +      T+ K   T+GK     K  S  E  +
Sbjct: 123  PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK----EKTTSAKETQS 178

Query: 976  PKKASSATITVTNTAIA-----TATVTATAIVTTTVTATATA---TATTTTTTTTISTIT 1027
             +K S+  +  T+  +A       T T    +TT    T T     A+TT    T +TI 
Sbjct: 179  IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK 238

Query: 1028 STITT 1032
            S  TT
Sbjct: 239  SAPTT 243



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 82/381 (21%), Positives = 122/381 (32%), Gaps = 40/381 (10%)

Query: 660  SVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSD 719
            S   H+      K T  KP     PRP++P   +  K          + E  ET ++   
Sbjct: 105  STTQHNKVSTSPKITTAKPI---NPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQ 161

Query: 720  SNTD-QEETLQIK------------VLPPCIISGGNTAKSKEIC-GASLTLSTLMSSSGS 765
            ++TD +E+T   K            + P   +    T K++    G +LT     + +  
Sbjct: 162  TSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTP 221

Query: 766  NNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAK 825
                S + +EPT + I    T    P            K      ++ P  ++    PA 
Sbjct: 222  KEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT-PKEPAP 280

Query: 826  PDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCIS 885
               KE A    + +A T  ++PAP   +K  P    E  P   +     T     P    
Sbjct: 281  TTTKEPAPTTTK-SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKE 339

Query: 886  PAP--PHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNI 943
            PAP  P +P  T     +    +       P P +P    P   +  S    P       
Sbjct: 340  PAPTTPKEPAPTAPKKPAPTTPKE------PAPTTPKEPAPTTTKEPSPTT-PKEPAPTT 392

Query: 944  AMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATI--TVTNTAIATATVTATAI 1001
              +   T+ +P  T  K   T          TPK+ S  T       T    A  T    
Sbjct: 393  TKSAPTTTKEPAPTTTKSAPT----------TPKEPSPTTTKEPAPTTPKEPAPTTPKKP 442

Query: 1002 VTTTVTATATATATTTTTTTT 1022
              TT    A  T      TTT
Sbjct: 443  APTTPKEPAPTTPKEPAPTTT 463


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 152/753 (20%), Positives = 234/753 (31%), Gaps = 77/753 (10%)

Query: 284  KPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSA----ASSKTKLPK 339
            K T  +     +D AP      KP+ + E +    +  T  +  P+     AS+  K P 
Sbjct: 215  KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274

Query: 340  FTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPG 399
             T ++++  + P +P+         T   P P T+   A  + +              P 
Sbjct: 275  PTTIKSAPTT-PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKE-------------PA 320

Query: 400  FTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAK 459
             T  K   PTT  S  +   K       K  +     EP  T   + T T   +     K
Sbjct: 321  PTTTKEPAPTTTKSAPTTP-KEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTK 379

Query: 460  PRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPE 519
                    P  T    PA  A      ++  E +  +  +   +TT     + P   TP+
Sbjct: 380  E-------PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT-----KEPSPTTPK 427

Query: 520  PEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQV 579
               P+T K           +  KS      E    T   P P           K  A   
Sbjct: 428  EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTT 487

Query: 580  PAEPK----ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVE 635
            P EP     + P  +  ++ A   P +  P T   K    TT + ++  T  K  P   E
Sbjct: 488  PKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTP--KETAPTTPKKLTPTTPEKLAPTTPE 545

Query: 636  KNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKK 695
            K   T         +  +TP+E       +P     KA A  P   KEP P  P  P   
Sbjct: 546  KPAPTTP-----EELAPTTPEEPTPTTPEEPAPTTPKAAA--PNTPKEPAPTTPKEPAPT 598

Query: 696  KYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG--AS 753
              + P    PK         +   +  +   T   K  P  +        +   C   A 
Sbjct: 599  TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 658

Query: 754  LTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV 813
             T      ++      +   E    +P     T +  P                      
Sbjct: 659  TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP---------------------- 696

Query: 814  PGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEE 873
                     P KP  KE A    +    T  +KPAP   ++  P    E  P   ++   
Sbjct: 697  -----APTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK-PA 750

Query: 874  ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN 933
             TT    PP  S      P  T+E  +  ++      +L   P     E+ P+   V   
Sbjct: 751  PTTPETPPPTTSEV--STPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTT 808

Query: 934  NGPFGQDKNIAMTGQ-ITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIA 992
              P      +  T +  T+ +  RT  +       ++     T +K + + IT T T + 
Sbjct: 809  KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVT 868

Query: 993  TATVTATAIVTTTVTATATATATTTTTTTTIST 1025
            + T   T     T   T T     TTT  TI+T
Sbjct: 869  STTTQDTTPFKITTLKTTTLAPKVTTTKKTITT 901



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 139/600 (23%), Positives = 205/600 (34%), Gaps = 64/600 (10%)

Query: 458  AKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVAT 517
            A+ ++N  N     P P P V    GSG  +     +  D+   S+T  ++ + +P++ T
Sbjct: 105  AEVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDT---STTQHNKVSTSPKITT 161

Query: 518  PEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNAS 577
             +P  P  +        N  TS+  S    + ET +ET        Q      +  T+A 
Sbjct: 162  AKPINPRPSLPP-----NSDTSKETSLTVNK-ETTVETKETTTTNKQTSTDGKEKTTSAK 215

Query: 578  QVPAEPK--ERPLLSLIREKARPRP------------TQKIPETKALKHKLSTTSETVSQ 623
            +  +  K   + L    +  A+P P            T K P     K   STT +  + 
Sbjct: 216  ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTP 275

Query: 624  RTI--GKKQPKKVEKNTSTDEFTWPK---PNITS----STPKEKESVELHDPPRGRNKA- 673
             TI      PK+    T+    T PK   P  T     +TPKE       +P     K+ 
Sbjct: 276  TTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSA 335

Query: 674  --TAHKPAPR--KEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQ 729
              T  +PAP   K+P P  P  P     + P    PK        ++   + T  +E   
Sbjct: 336  PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKE----PAPTTKEPAPTTPKEPAP 391

Query: 730  IKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEIL 789
                 P   +    A +     A  T      ++      + +   PT +  P   T   
Sbjct: 392  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 451

Query: 790  SPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAP 849
            +P    E       K       + P  ++    PA    KE A    ++ A T  +KPAP
Sbjct: 452  APTTPKEPSPTT-TKEPAPTTPKEPAPTT-PKKPAPTTPKEPAPTTPKEPAPTTTKKPAP 509

Query: 850  KGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKP-PNTRENNSSRRANRRK 908
               ++  P    E  P   ++L   T     P  ++P  P KP P T E      A    
Sbjct: 510  TTPKEPAPTTPKETAPTTPKKLTPTT-----PEKLAPTTPEKPAPTTPE----ELAPTTP 560

Query: 909  EEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMT--GQITSTKPKRT-----EGKF 961
            EE     P  P P  P      +         K  A T   +   T PK T     +G  
Sbjct: 561  EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA 620

Query: 962  CATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTT 1021
              T K  +     TPKK +   +  T T   T+T T      TT   TA  T      TT
Sbjct: 621  PTTLKEPAPT---TPKKPAPKELAPTTTKEPTST-TCDKPAPTTPKGTAPTTPKEPAPTT 676



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 131/628 (20%), Positives = 197/628 (31%), Gaps = 71/628 (11%)

Query: 464  PVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPP 523
            P  P   TP+ P          +  E   ++   + T        + + P   TP+   P
Sbjct: 262  PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 321

Query: 524  STNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEV-----QMKVKTNASQ 578
            +T K           +  K       + P  T    P    P E      +    T    
Sbjct: 322  TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 381

Query: 579  VPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNT 638
             P  PKE P  +  ++ A   P +  P T   K    TT++  S  T   K+P      +
Sbjct: 382  APTTPKE-PAPTAPKKPAPTTPKEPAPTTP--KEPAPTTTKEPSPTT--PKEPAPTTTKS 436

Query: 639  STDEFTWPKPNITSS---TPKEKESVELHDP----PRGRNKATAHKPAPR--KEPRPNIP 689
            +      P P  T S   TPKE       +P    P+     T  KPAP   KEP P  P
Sbjct: 437  APTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 496

Query: 690  LAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEI 749
              P     + P    PK        + T+   T      ++    P  ++     K    
Sbjct: 497  KEPAPTTTKKPAPTTPKE------PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPT 550

Query: 750  CGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDL 809
                L  +T               EEPT  P    +    +P     N      K     
Sbjct: 551  TPEELAPTT--------------PEEPT--PTTPEEPAPTTPKAAAPNTP----KEPAPT 590

Query: 810  LSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQ 869
              + P  ++    PA    KETA    + TA T +++PAP   +K  P E+A    +   
Sbjct: 591  TPKEPAPTT-PKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK--- 646

Query: 870  RLEEATTIC-----LLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDP 924
              E  +T C       P   +P  P +P  T     +    +         P    P+ P
Sbjct: 647  --EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 704

Query: 925  -PRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSAT 983
             P+    +   GP     +         T P   +     T K  +    +TP   +S  
Sbjct: 705  APKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEV 764

Query: 984  ITVTNTAIATATVTATAIVTTTVTATATATATTTT-------TTTTISTITSTITTGLMD 1036
             T T T   T    +    T  ++A  T  A   +       TT T +     +TT   D
Sbjct: 765  STPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD 824

Query: 1037 SSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
             +           L ++  T    PK+T
Sbjct: 825  KT-------TERDLRTTPETTTAAPKMT 845



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 87/409 (21%), Positives = 149/409 (36%), Gaps = 27/409 (6%)

Query: 341  TILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTP-- 398
            T L+    + P  P+  E  L   T   PT  T    A  + + T     +E    TP  
Sbjct: 622  TTLKEPAPTTPKKPAPKE--LAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 679

Query: 399  -GFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEK 457
               T  K   PTT       + K     +L  ++ +             T  E      K
Sbjct: 680  PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 739

Query: 458  AKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRV-- 515
                  P  P   TP+ PP   +   + ++++  ++     D   ST +  +   P+   
Sbjct: 740  EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALE 797

Query: 516  -ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT 574
             +  EP  P+T      K     T+++K+       TP ET +  P + +      + KT
Sbjct: 798  NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP-ETTTAAPKMTKETATTTE-KT 855

Query: 575  NASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKK--QPK 632
              S++ A   +  + S   +   P     + +T  L  K++TT +T++   I  K  +  
Sbjct: 856  TESKITATTTQ--VTSTTTQDTTPFKITTL-KTTTLAPKVTTTKKTITTTEIMNKPEETA 912

Query: 633  KVEKNTSTDEFTWPKPNITSSTPKEKESVEL-HDPPRGRNKATAHKPAPRK------EPR 685
            K +   +  + T PKP   +  PK+  S +     PR R   T   P PRK      E  
Sbjct: 913  KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT--PTPRKMTSTMPELN 970

Query: 686  PNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLP 734
            P   +A    +        P S+  +E +  + D+   + ET  + + P
Sbjct: 971  PTSRIAEAMLQTTTRPNQTPNSK-LVEVNPKSEDAGGAEGETPHMLLRP 1018



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 116/551 (21%), Positives = 179/551 (32%), Gaps = 61/551 (11%)

Query: 330 AASSKTKLPKFTILQTSEVSLPSDPS-CVEEILREMTHSWPTPLTSMHTAGHSEQSTFSI 388
           +A + TK P  T  +++  + P +PS    +     T   P P T    A  + +     
Sbjct: 436 SAPTTTKEPAPTTTKSAPTT-PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 494

Query: 389 PGQESQHLT---PGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLT-- 443
             +E    T   P  T  K   PTT   T   + K +     +  +     +P  T    
Sbjct: 495 TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 554

Query: 444 ---------TQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSS 494
                    T  T  E      KA   N P  P   TP+ P A         ++  E++ 
Sbjct: 555 LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP-APTTPKEPAPTTPKETAP 613

Query: 495 ESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKV--TSQNKSFICGQNETP 552
            +   T  +T    +   P+   P+   P+T K       +K   T+   +      E  
Sbjct: 614 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 673

Query: 553 METISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKH 612
             T   P P          +K  A   P +P  + L            T K P +     
Sbjct: 674 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT---------TTKGPTSTTSDK 724

Query: 613 KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKE-KESVELHDPPRGRN 671
              TT +  +  T  +  P   +K   T   T P      STP   KE   +H  P    
Sbjct: 725 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 784

Query: 672 KATAHKPAPRK-EPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQI 730
              + +P P+  E  P  P  P  K    P    P+     +  ++  D  T  E T   
Sbjct: 785 PELSAEPTPKALENSPKEPGVPTTKT---PAATKPEMTTTAKDKTTERDLRTTPETTTAA 841

Query: 731 -KVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEIL 789
            K+      +   T +SK      +T +T   +S        + ++ T   I  ++T  L
Sbjct: 842 PKMTKETATTTEKTTESK------ITATTTQVTS-------TTTQDTTPFKITTLKTTTL 888

Query: 790 SPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKET---ATKPKRQTAVTAVEK 846
           +P      +      I    +   P  +      AKP  + T   AT PK Q    A +K
Sbjct: 889 AP-----KVTTTKKTITTTEIMNKPEET------AKPKDRATNSKATTPKPQKPTKAPKK 937

Query: 847 PAPKGKRKHKP 857
           P    K K  P
Sbjct: 938 PTSTKKPKTMP 948



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 32/125 (25%), Positives = 49/125 (39%), Gaps = 12/125 (9%)

Query: 916  PLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDT 975
            P++P P  PP        +    ++  +      T+ K   T+GK     K  S  E  +
Sbjct: 164  PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK----EKTTSAKETQS 219

Query: 976  PKKASSATITVTNTAIA-----TATVTATAIVTTTVTATATA---TATTTTTTTTISTIT 1027
             +K S+  +  T+  +A       T T    +TT    T T     A+TT    T +TI 
Sbjct: 220  IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK 279

Query: 1028 STITT 1032
            S  TT
Sbjct: 280  SAPTT 284



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 82/381 (21%), Positives = 122/381 (32%), Gaps = 40/381 (10%)

Query: 660  SVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSD 719
            S   H+      K T  KP     PRP++P   +  K          + E  ET ++   
Sbjct: 146  STTQHNKVSTSPKITTAKPI---NPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQ 202

Query: 720  SNTD-QEETLQIK------------VLPPCIISGGNTAKSKEIC-GASLTLSTLMSSSGS 765
            ++TD +E+T   K            + P   +    T K++    G +LT     + +  
Sbjct: 203  TSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTP 262

Query: 766  NNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAK 825
                S + +EPT + I    T    P            K      ++ P  ++    PA 
Sbjct: 263  KEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT-PKEPAP 321

Query: 826  PDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCIS 885
               KE A    + +A T  ++PAP   +K  P    E  P   +     T     P    
Sbjct: 322  TTTKEPAPTTTK-SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKE 380

Query: 886  PAP--PHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNI 943
            PAP  P +P  T     +    +       P P +P    P   +  S    P       
Sbjct: 381  PAPTTPKEPAPTAPKKPAPTTPKE------PAPTTPKEPAPTTTKEPSPTT-PKEPAPTT 433

Query: 944  AMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATI--TVTNTAIATATVTATAI 1001
              +   T+ +P  T  K   T          TPK+ S  T       T    A  T    
Sbjct: 434  TKSAPTTTKEPAPTTTKSAPT----------TPKEPSPTTTKEPAPTTPKEPAPTTPKKP 483

Query: 1002 VTTTVTATATATATTTTTTTT 1022
              TT    A  T      TTT
Sbjct: 484  APTTPKEPAPTTPKEPAPTTT 504


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 157/762 (20%), Positives = 235/762 (30%), Gaps = 88/762 (11%)

Query: 284  KPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSA----ASSKTKLPK 339
            K T  +     +D AP      KP+ + E +    +  T  +  P+     AS+  K P 
Sbjct: 267  KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 326

Query: 340  FTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPG 399
             T ++++  + P +P+         T   P P T+   A  + +              P 
Sbjct: 327  PTTIKSAPTT-PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKE-------------PA 372

Query: 400  FTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAK 459
             T  K   PTT  S  +   K       K  +     EP  T   + T T   +     K
Sbjct: 373  PTTTKEPAPTTTKSAPTTP-KEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTK 431

Query: 460  PRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPE 519
                    P  T    PA  A      ++  E +  +  +   +TT     + P   TP+
Sbjct: 432  E-------PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT-----KEPSPTTPK 479

Query: 520  PEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQV 579
               P+T K           +  KS      E    T   P P           K  A   
Sbjct: 480  EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTT 539

Query: 580  PAEPK----ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVE 635
            P EP     + P  +  ++ A   P +  P T   K    TT + ++  T  K  P   E
Sbjct: 540  PKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTP--KETAPTTPKKLTPTTPEKLAPTTPE 597

Query: 636  KNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKK 695
            K   T         +  +TP+E       +P     KA A  P   KEP P  P  P   
Sbjct: 598  KPAPTTP-----EELAPTTPEEPTPTTPEEPAPTTPKAAA--PNTPKEPAPTTPKEPAPT 650

Query: 696  KYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG--AS 753
              + P    PK         +   +  +   T   K  P  +        +   C   A 
Sbjct: 651  TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 710

Query: 754  LTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV 813
             T      ++      +   E    +P     T +  P                      
Sbjct: 711  TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAP-------------------- 750

Query: 814  PGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEE 873
                     P KP  KE A    +    T  +KPAP   ++  P    E  P   ++   
Sbjct: 751  -------TTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK-PA 802

Query: 874  ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN 933
             TT    PP  S      P  T+E  +  ++      +L   P     E+ P+   V   
Sbjct: 803  PTTPETPPPTTSEVST--PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTT 860

Query: 934  NGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIAT 993
              P      +      T+ K K TE     T +  +      PK       T   T  + 
Sbjct: 861  KTPAATKPEMT-----TTAKDKTTERDLRTTPETTTA----APKMTKETATTTEKTTESK 911

Query: 994  ATVTATAIVTTTVTATATATATTTTTTTT---ISTITSTITT 1032
             T T T + +TT   T     TT  TTT    ++T   TITT
Sbjct: 912  ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITT 953



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 148/642 (23%), Positives = 217/642 (33%), Gaps = 67/642 (10%)

Query: 416  SVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPP 475
            SVS           SS    +  +K+        EL +   K K ++N  N     P P 
Sbjct: 118  SVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQK---KLKVKDNKKNRTKKKPTPK 174

Query: 476  PAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLN 535
            P V    GSG  +     +  D+   S+T  ++ + +P++ T +P  P  +        N
Sbjct: 175  PPVVDEAGSGLDNGDFKVTTPDT---STTQHNKVSTSPKITTAKPINPRPSLPP-----N 226

Query: 536  KVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPK--ERPLLSLIR 593
              TS+  S    + ET +ET        Q      +  T+A +  +  K   + L    +
Sbjct: 227  SDTSKETSLTVNK-ETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK 285

Query: 594  EKARPRP------------TQKIPETKALKHKLSTTSETVSQRTI--GKKQPKKVEKNTS 639
              A+P P            T K P     K   STT +  +  TI      PK+    T+
Sbjct: 286  VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 345

Query: 640  TDEFTWPK---PNITS----STPKEKESVELHDPPRGRNKA---TAHKPAPR--KEPRPN 687
                T PK   P  T     +TPKE       +P     K+   T  +PAP   K+P P 
Sbjct: 346  KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 405

Query: 688  IPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSK 747
             P  P     + P    PK        ++   + T  +E        P   +    A + 
Sbjct: 406  TPKEPAPTTPKEPTPTTPKE----PAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTT 461

Query: 748  EICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDL 807
                A  T      ++      + +   PT +  P   T   +P    E       K   
Sbjct: 462  PKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT-TKEPA 520

Query: 808  DLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEK 867
                + P  ++    PA    KE A    ++ A T  +KPAP   ++  P    E  P  
Sbjct: 521  PTTPKEPAPTT-PKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 579

Query: 868  KQRLEEATTICLLPPCISPAPPHKP-PNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPR 926
             ++L   T     P  ++P  P KP P T E      A    EE     P  P P  P  
Sbjct: 580  PKKLTPTT-----PEKLAPTTPEKPAPTTPE----ELAPTTPEEPTPTTPEEPAPTTPKA 630

Query: 927  RRNVSGNNGPFGQDKNIAMT--GQITSTKPKRT-----EGKFCATFKGISVNEGDTPKKA 979
                +         K  A T   +   T PK T     +G    T K  +     TPKK 
Sbjct: 631  AAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT---TPKKP 687

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTT 1021
            +   +  T T   T+T T      TT   TA  T      TT
Sbjct: 688  APKELAPTTTKEPTST-TCDKPAPTTPKGTAPTTPKEPAPTT 728



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 131/628 (20%), Positives = 197/628 (31%), Gaps = 71/628 (11%)

Query: 464  PVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPP 523
            P  P   TP+ P          +  E   ++   + T        + + P   TP+   P
Sbjct: 314  PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 373

Query: 524  STNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEV-----QMKVKTNASQ 578
            +T K           +  K       + P  T    P    P E      +    T    
Sbjct: 374  TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 433

Query: 579  VPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNT 638
             P  PKE P  +  ++ A   P +  P T   K    TT++  S  T   K+P      +
Sbjct: 434  APTTPKE-PAPTAPKKPAPTTPKEPAPTTP--KEPAPTTTKEPSPTT--PKEPAPTTTKS 488

Query: 639  STDEFTWPKPNITSS---TPKEKESVELHDP----PRGRNKATAHKPAPR--KEPRPNIP 689
            +      P P  T S   TPKE       +P    P+     T  KPAP   KEP P  P
Sbjct: 489  APTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 548

Query: 690  LAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEI 749
              P     + P    PK        + T+   T      ++    P  ++     K    
Sbjct: 549  KEPAPTTTKKPAPTTPKE------PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPT 602

Query: 750  CGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDL 809
                L  +T               EEPT  P    +    +P     N      K     
Sbjct: 603  TPEELAPTT--------------PEEPT--PTTPEEPAPTTPKAAAPNTP----KEPAPT 642

Query: 810  LSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQ 869
              + P  ++    PA    KETA    + TA T +++PAP   +K  P E+A    +   
Sbjct: 643  TPKEPAPTT-PKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK--- 698

Query: 870  RLEEATTIC-----LLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDP 924
              E  +T C       P   +P  P +P  T     +    +         P    P+ P
Sbjct: 699  --EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 756

Query: 925  -PRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSAT 983
             P+    +   GP     +         T P   +     T K  +    +TP   +S  
Sbjct: 757  APKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEV 816

Query: 984  ITVTNTAIATATVTATAIVTTTVTATATATATTTT-------TTTTISTITSTITTGLMD 1036
             T T T   T    +    T  ++A  T  A   +       TT T +     +TT   D
Sbjct: 817  STPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD 876

Query: 1037 SSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
             +           L ++  T    PK+T
Sbjct: 877  KT-------TERDLRTTPETTTAAPKMT 897



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 128/654 (19%), Positives = 208/654 (31%), Gaps = 55/654 (8%)

Query: 107 NNKNEPSFFPEQKNRIIPPHQDNTHPSAPMPPPSVVI-LNSTLIHSNRK-SKPEWSRDSH 164
           ++KN  +    QK   +  ++ N     P P P VV    S L + + K + P+ S   H
Sbjct: 143 SSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQH 202

Query: 165 NPSTVLASQASGQP-NKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPN 223
           N  +      + +P N   +L  +   +K     V      +  E   +N     D    
Sbjct: 203 NKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTD---- 258

Query: 224 SSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQ 283
             G++      ++ S E++     AP S ++A     P+         P L   T+  + 
Sbjct: 259 --GKEKTTSAKETQSIEKTSAKDLAPTSKVLAK----PTPKAETTTKGPAL---TTPKEP 309

Query: 284 KPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTIL 343
            PT    P     + P  + T+K +          +  +        A + TK P  T  
Sbjct: 310 TPTTPKEPASTTPKEPTPT-TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 368

Query: 344 QTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQ 403
           +    +   +P+         T   P P T    A  + +       +E    TP     
Sbjct: 369 KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 428

Query: 404 KWNDP--TTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPR 461
              +P  TT       + K       K  +     EP  T T + + T       K    
Sbjct: 429 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT-----TPKEPAP 483

Query: 462 NNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPE 521
               + P  T +P P    S  +     S ++++  + T        + + P   TP+  
Sbjct: 484 TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP 543

Query: 522 PPSTNKWQLDKWLNK--VTSQNKSFICGQNE----TPMETISLPPPIIQPMEVQMKVKTN 575
            P+T K        K   T+  +       E    TP +     P  + P   +    T 
Sbjct: 544 APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTT 603

Query: 576 ASQVPAEPKERPLLSLIREKARPRP------TQKIPETKALKHKLSTTSETVSQRTIGKK 629
             ++     E P  +   E A   P      T K P     K    TT +  +  T  K+
Sbjct: 604 PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP-TTPKE 662

Query: 630 QPKKVEKNTSTDEFTWPKP---------NITSSTPKEKESVELHDP----PRGRNKATAH 676
                 K T+      P P          +  +T KE  S     P    P+G    T  
Sbjct: 663 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 722

Query: 677 KPAPR--KEPRPNIPLAPEKKKYRGPGKIVPKS---REFIETDSSTSDSNTDQE 725
           +PAP   KEP P  P        + P    PK    +E   T +    S T  +
Sbjct: 723 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 776



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 87/409 (21%), Positives = 149/409 (36%), Gaps = 27/409 (6%)

Query: 341  TILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTP-- 398
            T L+    + P  P+  E  L   T   PT  T    A  + + T     +E    TP  
Sbjct: 674  TTLKEPAPTTPKKPAPKE--LAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 731

Query: 399  -GFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEK 457
               T  K   PTT       + K     +L  ++ +             T  E      K
Sbjct: 732  PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 791

Query: 458  AKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRV-- 515
                  P  P   TP+ PP   +   + ++++  ++     D   ST +  +   P+   
Sbjct: 792  EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALE 849

Query: 516  -ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT 574
             +  EP  P+T      K     T+++K+       TP ET +  P + +      + KT
Sbjct: 850  NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP-ETTTAAPKMTKETATTTE-KT 907

Query: 575  NASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKK--QPK 632
              S++ A   +  + S   +   P     + +T  L  K++TT +T++   I  K  +  
Sbjct: 908  TESKITATTTQ--VTSTTTQDTTPFKITTL-KTTTLAPKVTTTKKTITTTEIMNKPEETA 964

Query: 633  KVEKNTSTDEFTWPKPNITSSTPKEKESVEL-HDPPRGRNKATAHKPAPRK------EPR 685
            K +   +  + T PKP   +  PK+  S +     PR R   T   P PRK      E  
Sbjct: 965  KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT--PTPRKMTSTMPELN 1022

Query: 686  PNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLP 734
            P   +A    +        P S+  +E +  + D+   + ET  + + P
Sbjct: 1023 PTSRIAEAMLQTTTRPNQTPNSK-LVEVNPKSEDAGGAEGETPHMLLRP 1070



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 116/551 (21%), Positives = 179/551 (32%), Gaps = 61/551 (11%)

Query: 330  AASSKTKLPKFTILQTSEVSLPSDPS-CVEEILREMTHSWPTPLTSMHTAGHSEQSTFSI 388
            +A + TK P  T  +++  + P +PS    +     T   P P T    A  + +     
Sbjct: 488  SAPTTTKEPAPTTTKSAPTT-PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 546

Query: 389  PGQESQHLT---PGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLT-- 443
              +E    T   P  T  K   PTT   T   + K +     +  +     +P  T    
Sbjct: 547  TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 606

Query: 444  ---------TQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSS 494
                     T  T  E      KA   N P  P   TP+ P A         ++  E++ 
Sbjct: 607  LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP-APTTPKEPAPTTPKETAP 665

Query: 495  ESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKV--TSQNKSFICGQNETP 552
             +   T  +T    +   P+   P+   P+T K       +K   T+   +      E  
Sbjct: 666  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 725

Query: 553  METISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKH 612
              T   P P          +K  A   P +P  + L            T K P +     
Sbjct: 726  PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT---------TTKGPTSTTSDK 776

Query: 613  KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKE-KESVELHDPPRGRN 671
               TT +  +  T  +  P   +K   T   T P      STP   KE   +H  P    
Sbjct: 777  PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 836

Query: 672  KATAHKPAPRK-EPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQI 730
               + +P P+  E  P  P  P  K    P    P+     +  ++  D  T  E T   
Sbjct: 837  PELSAEPTPKALENSPKEPGVPTTKT---PAATKPEMTTTAKDKTTERDLRTTPETTTAA 893

Query: 731  -KVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEIL 789
             K+      +   T +SK      +T +T   +S        + ++ T   I  ++T  L
Sbjct: 894  PKMTKETATTTEKTTESK------ITATTTQVTS-------TTTQDTTPFKITTLKTTTL 940

Query: 790  SPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKET---ATKPKRQTAVTAVEK 846
            +P      +      I    +   P  +      AKP  + T   AT PK Q    A +K
Sbjct: 941  AP-----KVTTTKKTITTTEIMNKPEET------AKPKDRATNSKATTPKPQKPTKAPKK 989

Query: 847  PAPKGKRKHKP 857
            P    K K  P
Sbjct: 990  PTSTKKPKTMP 1000



 Score = 37.7 bits (86), Expect = 0.073
 Identities = 53/225 (23%), Positives = 81/225 (36%), Gaps = 18/225 (8%)

Query: 823  PAKPDHKETATKPKRQTAV---TAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICL 879
            P  P   + A  P   +     T    P P  K+K K +  +E+I E+    E   +   
Sbjct: 69   PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 128

Query: 880  LPPCISPAPPHKPPNTRENNSSRRANRR---KEEKLFPPPLSPLPEDPPRRRNVSG-NNG 935
                 S +   K  +++ + ++R   ++   K+ K       P P+ P      SG +NG
Sbjct: 129  SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 188

Query: 936  PFGQDKNIAMTGQIT--STKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIAT 993
             F        T Q    ST PK T  K       +  N  DT K+        T+  +  
Sbjct: 189  DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNS-DTSKE--------TSLTVNK 239

Query: 994  ATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSS 1038
             T   T   TTT   T+T     TT+     +I  T    L  +S
Sbjct: 240  ETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTS 284



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 99/470 (21%), Positives = 151/470 (32%), Gaps = 65/470 (13%)

Query: 592  IREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNIT 651
            +     P  ++K P        + +T++   +    KK  K +E    T+E +  +   +
Sbjct: 66   VHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQES 125

Query: 652  SSTPKEKESVELHDPPRGRNKATAH-------------KPAPRKEPRPNIPLAPEKKKYR 698
            SS+     S       +    + A+             K   +K+P P  P+  E     
Sbjct: 126  SSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGL 185

Query: 699  GPGKIVPKSREFIETDSSTSDSN---TDQEETLQIKVLP-PCIISGGNTAKSKEICGASL 754
              G       +    D+ST+  N   T  + T    + P P +    +T+K   +     
Sbjct: 186  DNGDF-----KVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKE 240

Query: 755  TLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVP 814
            T      ++ +N   S   +E T S       E  S        K+L       L    P
Sbjct: 241  TTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTS-------AKDL-APTSKVLAKPTP 292

Query: 815  GHSSLHAAPAKPDHKE-TATKPKRQTAVTAVE------KPAPKGKRKHKPIEVAEKIPEK 867
               +    PA    KE T T PK   + T  E      K AP   ++  P          
Sbjct: 293  KAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP 352

Query: 868  KQRLEEATTICLLPPCISPAPPHKPPNTRE--NNSSRRANRRKEEKLFPPPLSPLPEDP- 924
            K   E A T    P   +P  P  P  T+E    +++ A    +E     P  P P  P 
Sbjct: 353  K---EPAPTTTKEPAPTTPKEP-APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 408

Query: 925  ------PRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKK 978
                  P+    +    P    K  A T   T  +P  T  K  A           TPK+
Sbjct: 409  EPAPTTPKEPTPTTPKEPAPTTKEPAPT---TPKEPAPTAPKKPAP---------TTPKE 456

Query: 979  ASSAT---ITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTIST 1025
             +  T      T T   + T       TTT +A  T      TTT +  T
Sbjct: 457  PAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPT 506



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 32/125 (25%), Positives = 49/125 (39%), Gaps = 12/125 (9%)

Query: 916  PLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDT 975
            P++P P  PP        +    ++  +      T+ K   T+GK     K  S  E  +
Sbjct: 216  PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK----EKTTSAKETQS 271

Query: 976  PKKASSATITVTNTAIA-----TATVTATAIVTTTVTATATA---TATTTTTTTTISTIT 1027
             +K S+  +  T+  +A       T T    +TT    T T     A+TT    T +TI 
Sbjct: 272  IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK 331

Query: 1028 STITT 1032
            S  TT
Sbjct: 332  SAPTT 336


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 157/762 (20%), Positives = 235/762 (30%), Gaps = 88/762 (11%)

Query: 284  KPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSA----ASSKTKLPK 339
            K T  +     +D AP      KP+ + E +    +  T  +  P+     AS+  K P 
Sbjct: 308  KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 367

Query: 340  FTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPG 399
             T ++++  + P +P+         T   P P T+   A  + +              P 
Sbjct: 368  PTTIKSAPTT-PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKE-------------PA 413

Query: 400  FTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAK 459
             T  K   PTT  S  +   K       K  +     EP  T   + T T   +     K
Sbjct: 414  PTTTKEPAPTTTKSAPTTP-KEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTK 472

Query: 460  PRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPE 519
                    P  T    PA  A      ++  E +  +  +   +TT     + P   TP+
Sbjct: 473  E-------PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT-----KEPSPTTPK 520

Query: 520  PEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQV 579
               P+T K           +  KS      E    T   P P           K  A   
Sbjct: 521  EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTT 580

Query: 580  PAEPK----ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVE 635
            P EP     + P  +  ++ A   P +  P T   K    TT + ++  T  K  P   E
Sbjct: 581  PKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTP--KETAPTTPKKLTPTTPEKLAPTTPE 638

Query: 636  KNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKK 695
            K   T         +  +TP+E       +P     KA A  P   KEP P  P  P   
Sbjct: 639  KPAPTTP-----EELAPTTPEEPTPTTPEEPAPTTPKAAA--PNTPKEPAPTTPKEPAPT 691

Query: 696  KYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG--AS 753
              + P    PK         +   +  +   T   K  P  +        +   C   A 
Sbjct: 692  TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 751

Query: 754  LTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV 813
             T      ++      +   E    +P     T +  P                      
Sbjct: 752  TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAP-------------------- 791

Query: 814  PGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEE 873
                     P KP  KE A    +    T  +KPAP   ++  P    E  P   ++   
Sbjct: 792  -------TTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK-PA 843

Query: 874  ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN 933
             TT    PP  S      P  T+E  +  ++      +L   P     E+ P+   V   
Sbjct: 844  PTTPETPPPTTSEVST--PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTT 901

Query: 934  NGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIAT 993
              P      +      T+ K K TE     T +  +      PK       T   T  + 
Sbjct: 902  KTPAATKPEMT-----TTAKDKTTERDLRTTPETTTA----APKMTKETATTTEKTTESK 952

Query: 994  ATVTATAIVTTTVTATATATATTTTTTTT---ISTITSTITT 1032
             T T T + +TT   T     TT  TTT    ++T   TITT
Sbjct: 953  ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITT 994



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 148/642 (23%), Positives = 217/642 (33%), Gaps = 67/642 (10%)

Query: 416  SVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPP 475
            SVS           SS    +  +K+        EL +   K K ++N  N     P P 
Sbjct: 159  SVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQK---KLKVKDNKKNRTKKKPTPK 215

Query: 476  PAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLN 535
            P V    GSG  +     +  D+   S+T  ++ + +P++ T +P  P  +        N
Sbjct: 216  PPVVDEAGSGLDNGDFKVTTPDT---STTQHNKVSTSPKITTAKPINPRPSLPP-----N 267

Query: 536  KVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPK--ERPLLSLIR 593
              TS+  S    + ET +ET        Q      +  T+A +  +  K   + L    +
Sbjct: 268  SDTSKETSLTVNK-ETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK 326

Query: 594  EKARPRP------------TQKIPETKALKHKLSTTSETVSQRTI--GKKQPKKVEKNTS 639
              A+P P            T K P     K   STT +  +  TI      PK+    T+
Sbjct: 327  VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 386

Query: 640  TDEFTWPK---PNITS----STPKEKESVELHDPPRGRNKA---TAHKPAPR--KEPRPN 687
                T PK   P  T     +TPKE       +P     K+   T  +PAP   K+P P 
Sbjct: 387  KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 446

Query: 688  IPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSK 747
             P  P     + P    PK        ++   + T  +E        P   +    A + 
Sbjct: 447  TPKEPAPTTPKEPTPTTPKE----PAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTT 502

Query: 748  EICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDL 807
                A  T      ++      + +   PT +  P   T   +P    E       K   
Sbjct: 503  PKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT-TKEPA 561

Query: 808  DLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEK 867
                + P  ++    PA    KE A    ++ A T  +KPAP   ++  P    E  P  
Sbjct: 562  PTTPKEPAPTT-PKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 620

Query: 868  KQRLEEATTICLLPPCISPAPPHKP-PNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPR 926
             ++L   T     P  ++P  P KP P T E      A    EE     P  P P  P  
Sbjct: 621  PKKLTPTT-----PEKLAPTTPEKPAPTTPE----ELAPTTPEEPTPTTPEEPAPTTPKA 671

Query: 927  RRNVSGNNGPFGQDKNIAMT--GQITSTKPKRT-----EGKFCATFKGISVNEGDTPKKA 979
                +         K  A T   +   T PK T     +G    T K  +     TPKK 
Sbjct: 672  AAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT---TPKKP 728

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTT 1021
            +   +  T T   T+T T      TT   TA  T      TT
Sbjct: 729  APKELAPTTTKEPTST-TCDKPAPTTPKGTAPTTPKEPAPTT 769



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 131/628 (20%), Positives = 197/628 (31%), Gaps = 71/628 (11%)

Query: 464  PVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPP 523
            P  P   TP+ P          +  E   ++   + T        + + P   TP+   P
Sbjct: 355  PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 414

Query: 524  STNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEV-----QMKVKTNASQ 578
            +T K           +  K       + P  T    P    P E      +    T    
Sbjct: 415  TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 474

Query: 579  VPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNT 638
             P  PKE P  +  ++ A   P +  P T   K    TT++  S  T   K+P      +
Sbjct: 475  APTTPKE-PAPTAPKKPAPTTPKEPAPTTP--KEPAPTTTKEPSPTT--PKEPAPTTTKS 529

Query: 639  STDEFTWPKPNITSS---TPKEKESVELHDP----PRGRNKATAHKPAPR--KEPRPNIP 689
            +      P P  T S   TPKE       +P    P+     T  KPAP   KEP P  P
Sbjct: 530  APTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 589

Query: 690  LAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEI 749
              P     + P    PK        + T+   T      ++    P  ++     K    
Sbjct: 590  KEPAPTTTKKPAPTTPKE------PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPT 643

Query: 750  CGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDL 809
                L  +T               EEPT  P    +    +P     N      K     
Sbjct: 644  TPEELAPTT--------------PEEPT--PTTPEEPAPTTPKAAAPNTP----KEPAPT 683

Query: 810  LSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQ 869
              + P  ++    PA    KETA    + TA T +++PAP   +K  P E+A    +   
Sbjct: 684  TPKEPAPTT-PKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK--- 739

Query: 870  RLEEATTIC-----LLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDP 924
              E  +T C       P   +P  P +P  T     +    +         P    P+ P
Sbjct: 740  --EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 797

Query: 925  -PRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSAT 983
             P+    +   GP     +         T P   +     T K  +    +TP   +S  
Sbjct: 798  APKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEV 857

Query: 984  ITVTNTAIATATVTATAIVTTTVTATATATATTTT-------TTTTISTITSTITTGLMD 1036
             T T T   T    +    T  ++A  T  A   +       TT T +     +TT   D
Sbjct: 858  STPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD 917

Query: 1037 SSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
             +           L ++  T    PK+T
Sbjct: 918  KT-------TERDLRTTPETTTAAPKMT 938



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 128/654 (19%), Positives = 208/654 (31%), Gaps = 55/654 (8%)

Query: 107 NNKNEPSFFPEQKNRIIPPHQDNTHPSAPMPPPSVVI-LNSTLIHSNRK-SKPEWSRDSH 164
           ++KN  +    QK   +  ++ N     P P P VV    S L + + K + P+ S   H
Sbjct: 184 SSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQH 243

Query: 165 NPSTVLASQASGQP-NKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPN 223
           N  +      + +P N   +L  +   +K     V      +  E   +N     D    
Sbjct: 244 NKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTD---- 299

Query: 224 SSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQ 283
             G++      ++ S E++     AP S ++A     P+         P L   T+  + 
Sbjct: 300 --GKEKTTSAKETQSIEKTSAKDLAPTSKVLAK----PTPKAETTTKGPAL---TTPKEP 350

Query: 284 KPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTIL 343
            PT    P     + P  + T+K +          +  +        A + TK P  T  
Sbjct: 351 TPTTPKEPASTTPKEPTPT-TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 409

Query: 344 QTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQ 403
           +    +   +P+         T   P P T    A  + +       +E    TP     
Sbjct: 410 KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 469

Query: 404 KWNDP--TTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPR 461
              +P  TT       + K       K  +     EP  T T + + T       K    
Sbjct: 470 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT-----TPKEPAP 524

Query: 462 NNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPE 521
               + P  T +P P    S  +     S ++++  + T        + + P   TP+  
Sbjct: 525 TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP 584

Query: 522 PPSTNKWQLDKWLNK--VTSQNKSFICGQNE----TPMETISLPPPIIQPMEVQMKVKTN 575
            P+T K        K   T+  +       E    TP +     P  + P   +    T 
Sbjct: 585 APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTT 644

Query: 576 ASQVPAEPKERPLLSLIREKARPRP------TQKIPETKALKHKLSTTSETVSQRTIGKK 629
             ++     E P  +   E A   P      T K P     K    TT +  +  T  K+
Sbjct: 645 PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP-TTPKE 703

Query: 630 QPKKVEKNTSTDEFTWPKP---------NITSSTPKEKESVELHDP----PRGRNKATAH 676
                 K T+      P P          +  +T KE  S     P    P+G    T  
Sbjct: 704 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 763

Query: 677 KPAPR--KEPRPNIPLAPEKKKYRGPGKIVPKS---REFIETDSSTSDSNTDQE 725
           +PAP   KEP P  P        + P    PK    +E   T +    S T  +
Sbjct: 764 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 817



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 87/409 (21%), Positives = 149/409 (36%), Gaps = 27/409 (6%)

Query: 341  TILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTP-- 398
            T L+    + P  P+  E  L   T   PT  T    A  + + T     +E    TP  
Sbjct: 715  TTLKEPAPTTPKKPAPKE--LAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 772

Query: 399  -GFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEK 457
               T  K   PTT       + K     +L  ++ +             T  E      K
Sbjct: 773  PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 832

Query: 458  AKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRV-- 515
                  P  P   TP+ PP   +   + ++++  ++     D   ST +  +   P+   
Sbjct: 833  EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALE 890

Query: 516  -ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT 574
             +  EP  P+T      K     T+++K+       TP ET +  P + +      + KT
Sbjct: 891  NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP-ETTTAAPKMTKETATTTE-KT 948

Query: 575  NASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKK--QPK 632
              S++ A   +  + S   +   P     + +T  L  K++TT +T++   I  K  +  
Sbjct: 949  TESKITATTTQ--VTSTTTQDTTPFKITTL-KTTTLAPKVTTTKKTITTTEIMNKPEETA 1005

Query: 633  KVEKNTSTDEFTWPKPNITSSTPKEKESVEL-HDPPRGRNKATAHKPAPRK------EPR 685
            K +   +  + T PKP   +  PK+  S +     PR R   T   P PRK      E  
Sbjct: 1006 KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT--PTPRKMTSTMPELN 1063

Query: 686  PNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLP 734
            P   +A    +        P S+  +E +  + D+   + ET  + + P
Sbjct: 1064 PTSRIAEAMLQTTTRPNQTPNSK-LVEVNPKSEDAGGAEGETPHMLLRP 1111



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 116/551 (21%), Positives = 179/551 (32%), Gaps = 61/551 (11%)

Query: 330  AASSKTKLPKFTILQTSEVSLPSDPS-CVEEILREMTHSWPTPLTSMHTAGHSEQSTFSI 388
            +A + TK P  T  +++  + P +PS    +     T   P P T    A  + +     
Sbjct: 529  SAPTTTKEPAPTTTKSAPTT-PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 587

Query: 389  PGQESQHLT---PGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLT-- 443
              +E    T   P  T  K   PTT   T   + K +     +  +     +P  T    
Sbjct: 588  TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 647

Query: 444  ---------TQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSS 494
                     T  T  E      KA   N P  P   TP+ P A         ++  E++ 
Sbjct: 648  LAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP-APTTPKEPAPTTPKETAP 706

Query: 495  ESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKV--TSQNKSFICGQNETP 552
             +   T  +T    +   P+   P+   P+T K       +K   T+   +      E  
Sbjct: 707  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 766

Query: 553  METISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKH 612
              T   P P          +K  A   P +P  + L            T K P +     
Sbjct: 767  PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT---------TTKGPTSTTSDK 817

Query: 613  KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKE-KESVELHDPPRGRN 671
               TT +  +  T  +  P   +K   T   T P      STP   KE   +H  P    
Sbjct: 818  PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 877

Query: 672  KATAHKPAPRK-EPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQI 730
               + +P P+  E  P  P  P  K    P    P+     +  ++  D  T  E T   
Sbjct: 878  PELSAEPTPKALENSPKEPGVPTTKT---PAATKPEMTTTAKDKTTERDLRTTPETTTAA 934

Query: 731  -KVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEIL 789
             K+      +   T +SK      +T +T   +S        + ++ T   I  ++T  L
Sbjct: 935  PKMTKETATTTEKTTESK------ITATTTQVTS-------TTTQDTTPFKITTLKTTTL 981

Query: 790  SPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKET---ATKPKRQTAVTAVEK 846
            +P      +      I    +   P  +      AKP  + T   AT PK Q    A +K
Sbjct: 982  AP-----KVTTTKKTITTTEIMNKPEET------AKPKDRATNSKATTPKPQKPTKAPKK 1030

Query: 847  PAPKGKRKHKP 857
            P    K K  P
Sbjct: 1031 PTSTKKPKTMP 1041



 Score = 37.7 bits (86), Expect = 0.073
 Identities = 53/225 (23%), Positives = 81/225 (36%), Gaps = 18/225 (8%)

Query: 823  PAKPDHKETATKPKRQTAV---TAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICL 879
            P  P   + A  P   +     T    P P  K+K K +  +E+I E+    E   +   
Sbjct: 110  PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 169

Query: 880  LPPCISPAPPHKPPNTRENNSSRRANRR---KEEKLFPPPLSPLPEDPPRRRNVSG-NNG 935
                 S +   K  +++ + ++R   ++   K+ K       P P+ P      SG +NG
Sbjct: 170  SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 229

Query: 936  PFGQDKNIAMTGQIT--STKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIAT 993
             F        T Q    ST PK T  K       +  N  DT K+        T+  +  
Sbjct: 230  DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNS-DTSKE--------TSLTVNK 280

Query: 994  ATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSS 1038
             T   T   TTT   T+T     TT+     +I  T    L  +S
Sbjct: 281  ETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTS 325



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 99/470 (21%), Positives = 151/470 (32%), Gaps = 65/470 (13%)

Query: 592  IREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNIT 651
            +     P  ++K P        + +T++   +    KK  K +E    T+E +  +   +
Sbjct: 107  VHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQES 166

Query: 652  SSTPKEKESVELHDPPRGRNKATAH-------------KPAPRKEPRPNIPLAPEKKKYR 698
            SS+     S       +    + A+             K   +K+P P  P+  E     
Sbjct: 167  SSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGL 226

Query: 699  GPGKIVPKSREFIETDSSTSDSN---TDQEETLQIKVLP-PCIISGGNTAKSKEICGASL 754
              G       +    D+ST+  N   T  + T    + P P +    +T+K   +     
Sbjct: 227  DNGDF-----KVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKE 281

Query: 755  TLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVP 814
            T      ++ +N   S   +E T S       E  S        K+L       L    P
Sbjct: 282  TTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTS-------AKDL-APTSKVLAKPTP 333

Query: 815  GHSSLHAAPAKPDHKE-TATKPKRQTAVTAVE------KPAPKGKRKHKPIEVAEKIPEK 867
               +    PA    KE T T PK   + T  E      K AP   ++  P          
Sbjct: 334  KAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP 393

Query: 868  KQRLEEATTICLLPPCISPAPPHKPPNTRE--NNSSRRANRRKEEKLFPPPLSPLPEDP- 924
            K   E A T    P   +P  P  P  T+E    +++ A    +E     P  P P  P 
Sbjct: 394  K---EPAPTTTKEPAPTTPKEP-APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 449

Query: 925  ------PRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKK 978
                  P+    +    P    K  A T   T  +P  T  K  A           TPK+
Sbjct: 450  EPAPTTPKEPTPTTPKEPAPTTKEPAPT---TPKEPAPTAPKKPAP---------TTPKE 497

Query: 979  ASSAT---ITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTIST 1025
             +  T      T T   + T       TTT +A  T      TTT +  T
Sbjct: 498  PAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPT 547



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 32/125 (25%), Positives = 49/125 (39%), Gaps = 12/125 (9%)

Query: 916  PLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDT 975
            P++P P  PP        +    ++  +      T+ K   T+GK     K  S  E  +
Sbjct: 257  PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK----EKTTSAKETQS 312

Query: 976  PKKASSATITVTNTAIA-----TATVTATAIVTTTVTATATA---TATTTTTTTTISTIT 1027
             +K S+  +  T+  +A       T T    +TT    T T     A+TT    T +TI 
Sbjct: 313  IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIK 372

Query: 1028 STITT 1032
            S  TT
Sbjct: 373  SAPTT 377


>gi|113417084 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 194

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 39/89 (43%), Positives = 47/89 (52%), Gaps = 2/89 (2%)

Query: 946  TGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATI--TVTNTAIATATVTATAIVT 1003
            T  IT+T    T      T   I+     T    ++ T   T+T T   T T T T I T
Sbjct: 103  TTTITTTTTTTTTTTTTTTITTITTTTTTTITTTTTTTTITTITTTTTTTITTTTTTITT 162

Query: 1004 TTVTATATATATTTTTTTTISTITSTITT 1032
            TT+T T T T TTTTTTTTI+TIT+T TT
Sbjct: 163  TTITTTTTTTITTTTTTTTITTITTTTTT 191



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 33/90 (36%), Positives = 48/90 (53%), Gaps = 1/90 (1%)

Query: 975  TPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGL 1034
            T    ++ T T+T T   T T T T  +TT +T T T T TTTTTTTTI+TIT+T TT +
Sbjct: 95   TTTTTTTTTTTITTTTTTTTTTTTTTTITT-ITTTTTTTITTTTTTTTITTITTTTTTTI 153

Query: 1035 MDSSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
              ++    T+       ++ +T      +T
Sbjct: 154  TTTTTTITTTTITTTTTTTITTTTTTTTIT 183



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 30/82 (36%), Positives = 45/82 (54%)

Query: 975  TPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGL 1034
            T    ++ T T+T T   T+T T T I TTT T T T T  TTTTTTT +T T+T  T +
Sbjct: 66   TTTTITTTTSTITTTTTTTSTTTITTITTTTTTTTTTTTTITTTTTTTTTTTTTTTITTI 125

Query: 1035 MDSSHLEMTSWAALPLLSSSST 1056
              ++   +T+      +++ +T
Sbjct: 126  TTTTTTTITTTTTTTTITTITT 147



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 29/77 (37%), Positives = 44/77 (57%)

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSH 1039
            ++ T T   T  +T T T T   TTT+T   T T TTTTTTTTI+T T+T TT    ++ 
Sbjct: 63   TTTTTTTITTTTSTITTTTTTTSTTTITTITTTTTTTTTTTTTITTTTTTTTTTTTTTTI 122

Query: 1040 LEMTSWAALPLLSSSST 1056
              +T+     + ++++T
Sbjct: 123  TTITTTTTTTITTTTTT 139



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 45/169 (26%), Positives = 68/169 (40%), Gaps = 13/169 (7%)

Query: 890  HKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQI 949
            HK     +++ S   ++R+ +   P P            N +G++           T   
Sbjct: 18   HKELWADQDSGSNSISQRRNQIYAPLP------------NTAGSSIALLLPTTTITTTTT 65

Query: 950  TSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTAT 1009
            T+T    T      T    S     T    ++ T T T T   T T T T   TTT+T  
Sbjct: 66   TTTTITTTTSTITTTTTTTSTTTITTITTTTTTTTTTTTTITTTTTTTTTTTTTTTITTI 125

Query: 1010 ATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNV 1058
             T T TT TTTTT +TIT TITT    +     T+     + ++++T +
Sbjct: 126  TTTTTTTITTTTTTTTIT-TITTTTTTTITTTTTTITTTTITTTTTTTI 173



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 28/77 (36%), Positives = 42/77 (54%)

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSH 1039
            ++ T T T T I T T T T  +TTT T T   T TTTTTTT  +T T+  TT +  ++ 
Sbjct: 111  TTTTTTTTTTTITTITTTTTTTITTTTTTTTITTITTTTTTTITTTTTTITTTTITTTTT 170

Query: 1040 LEMTSWAALPLLSSSST 1056
              +T+      +++ +T
Sbjct: 171  TTITTTTTTTTITTITT 187



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 31/94 (32%), Positives = 47/94 (50%), Gaps = 4/94 (4%)

Query: 975  TPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTT----TTISTITSTI 1030
            T    ++ T T + T I T T T T   TTT T T T T TTTTTT    TTI+T T+T 
Sbjct: 73   TTSTITTTTTTTSTTTITTITTTTTTTTTTTTTITTTTTTTTTTTTTTTITTITTTTTTT 132

Query: 1031 TTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
             T    ++ +   +      +++++T +    +T
Sbjct: 133  ITTTTTTTTITTITTTTTTTITTTTTTITTTTIT 166



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 36/114 (31%), Positives = 50/114 (43%)

Query: 943  IAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIV 1002
            I  T   TST    T      T    +     T    ++ T T T T I T T T     
Sbjct: 77   ITTTTTTTSTTTITTITTTTTTTTTTTTTITTTTTTTTTTTTTTTITTITTTTTTTITTT 136

Query: 1003 TTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSST 1056
            TTT T T   T TTTT TTT +TIT+T  T    ++    T+   +  +++++T
Sbjct: 137  TTTTTITTITTTTTTTITTTTTTITTTTITTTTTTTITTTTTTTTITTITTTTT 190



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 6/90 (6%)

Query: 981  SATITVTNTAIATATVTATAIVTTTVTA------TATATATTTTTTTTISTITSTITTGL 1034
            + TIT T T   T T T + I TTT T       T T T TTTTTTTT  T T+T TT  
Sbjct: 57   TTTITTTTTTTTTITTTTSTITTTTTTTSTTTITTITTTTTTTTTTTTTITTTTTTTTTT 116

Query: 1035 MDSSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
              ++ +   +      +++++T      +T
Sbjct: 117  TTTTTITTITTTTTTTITTTTTTTTITTIT 146



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 29/88 (32%), Positives = 38/88 (43%)

Query: 943  IAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIV 1002
            I  T   T+T    T      T    ++    T    ++ T T T T   T T   T  +
Sbjct: 106  ITTTTTTTTTTTTTTTITTITTTTTTTITTTTTTTTITTITTTTTTTITTTTTTITTTTI 165

Query: 1003 TTTVTATATATATTTTTTTTISTITSTI 1030
            TTT T T T T TTTT TT  +T T+ +
Sbjct: 166  TTTTTTTITTTTTTTTITTITTTTTTCV 193


>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
            sapiens]
          Length = 1393

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 193/958 (20%), Positives = 319/958 (33%), Gaps = 135/958 (14%)

Query: 155  SKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNP 214
            ++P  +R+         S A    N+  T  +  + + +E     P E  +    E++ P
Sbjct: 439  AEPTENRERTANENTTPSPAGPTENRETTANEKTTLSPVE-----PTENRETTANEKTTP 493

Query: 215  SAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGL 274
            S  E +  N        E   S+S E +E   + P    +A+    PS     +N     
Sbjct: 494  SPAEPTE-NGQRTPFANEKTTSSSAEPTEHGERTP----LANENTTPSPAEPTENRERTA 548

Query: 275  YCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSK 334
              KT+    +PT      +  D+ P  +    PS+      G          +   A+ K
Sbjct: 549  NEKTTPSPAEPT------ENGDRTPLANEKTTPSLAEPTENGQ---------RTPFANEK 593

Query: 335  TKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQ 394
            T         TS  + P++            H   TPL + +T     + T +     ++
Sbjct: 594  T---------TSSSAEPTE------------HEERTPLANENTTPSPAEPTENRERTANE 632

Query: 395  HLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQA 454
            + TP       N   T A+ K+  F +   ++ + +++E      KT ++    TE  Q 
Sbjct: 633  NTTPSPAGPTENREMT-ANEKTTLFPAEPTENRERTANE------KTTSSPAEPTENGQR 685

Query: 455  VEKAKPRNN-----PVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSES 509
               A  +       P      TP        S    + +   +++E  +   +  T++  
Sbjct: 686  TPFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRE 745

Query: 510  NEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQ 569
              A    TP P  P+ N  +      K T            TP           +P E  
Sbjct: 746  RTANENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTEHA 805

Query: 570  MKV---KTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTI 626
             +      N +  PAEP E       RE+     T + P  +  +++ ST +E       
Sbjct: 806  ERTPLANENTTSSPAEPTEN------RERTANEKTTQFP-AEPTENRESTANE------- 851

Query: 627  GKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKE--- 683
             K  P   E    T+   W     T+ +P E    E   P    N+ T   PA   E   
Sbjct: 852  -KTTPFPAEP---TENREWTANENTTLSPAEPTEHEEMTPLA--NEKTTLSPAEPTENGE 905

Query: 684  --PRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGG 741
              P  N    P   +    G+  P + E   T  S ++     E     K  P       
Sbjct: 906  RTPFTNEKTTPSSAEPTEHGERTPLANEI--TTPSRAEPTEHGERIANEKATP------- 956

Query: 742  NTAKSKEICGASLTLSTLMSSSGSNNN---LSISNEEPTFSPIPVMQTEILSPLRDHENL 798
            + AK  E    ++   T  SS+    N     ++NE  T SP     TE         N 
Sbjct: 957  SPAKPTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSP-----TESTEHGERTANE 1011

Query: 799  KNLWVKID-LDLLSRVPG-HSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHK 856
            K      +  +   R P  +     +PAKP   E  T    +    +  KP   G++   
Sbjct: 1012 KTTPSPAEPTEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTL 1071

Query: 857  PIEVAEKIPEKKQRLEEATTIC--LLPPCISPAPPH----KPPNTRENNSSRRANRRKEE 910
              E     PE        TT     + P ++    H      PN +  +S+  +   ++ 
Sbjct: 1072 ANEKITLSPEGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDR 1131

Query: 911  KLFPPPLSPLPEDP---PRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRT---------- 957
                  ++P P +P    +R  ++        +K+     + TST  K T          
Sbjct: 1132 ATSANVITPAPAEPIKHAKRTTLAHEKMTQVTEKSTEHPEKTTSTTEKTTRTPEKPTLYS 1191

Query: 958  EGKFCATFKGISVNE------GDTPKKASSATITVTNTAIATATVTATAIVTTTVTATAT 1011
            E   C   K   V E      G+T     +    V +T     T   T  +  +V  T  
Sbjct: 1192 EKTICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTENPEKTAAVTKTIKPSVKVTGD 1251

Query: 1012 ATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSST-NVRRPKLTFDDS 1068
             + TTT++    + +T  + TG    S   +TS   L  ++S +T N   P L  D S
Sbjct: 1252 KSLTTTSSHLNKTEVTHQVPTG----SFTLITSRTKLSSITSEATGNESHPYLNKDGS 1305



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 141/707 (19%), Positives = 235/707 (33%), Gaps = 111/707 (15%)

Query: 476  PAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLN 535
            PA     G  +++E+ + S ++       T +E+       TP P  P+ +  +     +
Sbjct: 358  PAEPTEHGERTANENTTPSPAEPTEHGERTANENT------TPSPAEPTEHGERTPFAND 411

Query: 536  KVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMK-VKTNASQVPAEPKERPLLSLIRE 594
            K TS +         TP+   +  P   +P E + +    N +  PA P E    +   E
Sbjct: 412  KTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTEN-RETTANE 470

Query: 595  KARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNIT--- 651
            K    P +   E +       TT         G++ P   EK TS+          T   
Sbjct: 471  KTTLSPVEP-TENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLA 529

Query: 652  --SSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEK-----KKYRGPGKIV 704
              ++TP   E  E  +  R  N+ T   PA   E     PLA EK      +    G+  
Sbjct: 530  NENTTPSPAEPTENRE--RTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRT 587

Query: 705  PKSREFIETDSSTSDSNTDQEET-LQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSS 763
            P + E  +T SS+++    +E T L  +   P      + A+  E    +   +T  S +
Sbjct: 588  PFANE--KTTSSSAEPTEHEERTPLANENTTP------SPAEPTENRERTANENTTPSPA 639

Query: 764  GSNNNLSI-SNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAA 822
            G   N  + +NE+ T  P          P  + E   N                    ++
Sbjct: 640  GPTENREMTANEKTTLFP--------AEPTENRERTAN----------------EKTTSS 675

Query: 823  PAKPDHKETATKPKRQTAVTAVEKPAPKGKR-----KHKPIEVAEKIPEKKQRLEEATTI 877
            PA+P      T    +   ++  +P   G+R     ++  +  AE    +++   E TT 
Sbjct: 676  PAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTP 735

Query: 878  CLLPP------------CISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPP 925
                P              SPA P     T   + +  AN +    L  P  +       
Sbjct: 736  FPAEPTENRERTANENTTPSPAQP-----TENGDRTPLANEKTTPSLAEPTENGKRTPFA 790

Query: 926  RRRNVSGNNGPFGQDKNIAMTGQITSTKP-------KRTEGKFCATF-------KGISVN 971
              +  S +  P    +   +  + T++ P       +RT  +    F       +  + N
Sbjct: 791  NEKTTSSSAEPTEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTAN 850

Query: 972  EGDTPKKASSAT----ITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTIT 1027
            E  TP  A            NT ++ A  T    +T       T +    T     +  T
Sbjct: 851  EKTTPFPAEPTENREWTANENTTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTPFT 910

Query: 1028 STITT--GLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHK 1085
            +  TT      + H E T     PL +  +T  R       + + N       AK  +H 
Sbjct: 911  NEKTTPSSAEPTEHGERT-----PLANEITTPSRAEPTEHGERIANEKATPSPAKPTEH- 964

Query: 1086 ADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVE 1132
                    G+     D   S  E     ER PL  ++  T  +E+ E
Sbjct: 965  --------GETTVNEDTTPSSAEPTENGERTPLANENTTTSPTESTE 1003


>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
          Length = 5478

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 193/947 (20%), Positives = 316/947 (33%), Gaps = 122/947 (12%)

Query: 154  KSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESN 213
            +S P     S   +T L    +  P+  +  T   +  +  D  + PA     G  EES+
Sbjct: 4051 ESTPSRLSPSSTETTTLPGSPT-TPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESS 4109

Query: 214  PSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPG 273
             S    S P S+   AF +   ++   +          P  + S    S G +     PG
Sbjct: 4110 TS---HSQPGSTHTTAFPDSTTTSGLSQE---------PTTSHS----SQGSTEATLSPG 4153

Query: 274  LYCKTSMGQQKPTAYVRPMDGQDQA-PDISPT---LKPSIEFENSFGNLSFGTLLDGKPS 329
                +S+GQQ  T +  P D +    PD + T   ++ S    +S G+L   TL     +
Sbjct: 4154 STTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHT-TLTPASST 4212

Query: 330  AASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMT--HSWPTPLTSMH------TAGHS 381
            +   + +   F    +S  + PS PS     +   T  HS P+   + H      T G S
Sbjct: 4213 STGLQEESTTFQSWPSSSDTTPSPPSTTAVPVEVSTTYHSRPSSTPTTHFSASSTTLGRS 4272

Query: 382  EQST--FSIPGQESQHLTP--GFTLQKWNDPTTR----ASTKSVSFK-SMLEDDLKLSSD 432
            E+ST   S PG     L P    T     +PTT      ST++ +   S     L   S 
Sbjct: 4273 EESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKST 4332

Query: 433  EDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESES 492
                 P    TT   A+     V +    ++     + T   P +    G S  S+ S S
Sbjct: 4333 TFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSMHTTAFPSSTTMPGVSQESTASHS 4392

Query: 493  SSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQL-DKWLNKVTSQNKSFICGQNET 551
            S  S   T S  + + S+  P   T    P ST    L D        +  + +     +
Sbjct: 4393 SPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGS 4452

Query: 552  PMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALK 611
            P  T+S      +  E      T     P      P        A P  T    E     
Sbjct: 4453 PHTTLSPAGSTTRQGE-----STTFQSWPNSKDTTP--------APPTTTSAFVELSTTS 4499

Query: 612  H----KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPP 667
            H       TT  + S  T+G+ +      ++     T P P  ++++   +ES   H  P
Sbjct: 4500 HGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSP 4559

Query: 668  ----------------RGRNKATAHKPAPR---KEPRPNIPLAPEKKKYR-GPGKIVPKS 707
                            RG    T+H          P     L  E   Y   PG      
Sbjct: 4560 GSTQTMHFPESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTH 4619

Query: 708  REFIETDSSTSDSNT---DQEETLQIKVLP----PCIISGGNTAKSKEICGASLTLSTLM 760
                 T S  S+ +T     ++     VLP      ++ G +T  +  I   S+  + L 
Sbjct: 4620 FPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGEST--TSPISSGSMETTAL- 4676

Query: 761  SSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLH 820
               GS     +S +  TF   P              +            L R    +++H
Sbjct: 4677 --PGSTTTPGLSEKSTTFHSSP-------------SSTPTTHFSASSTTLGRSEESTTVH 4721

Query: 821  AAPAKPDHKETATKPKRQTAVTAVEKPAP------KGKRKHKPIEVAEKIPEKKQRLEEA 874
            ++P       T   P R T    VE+           +  H P         ++ R   +
Sbjct: 4722 SSPVA---TATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRTSHS 4778

Query: 875  TTICLL--PPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSG 932
            +T   +  PP  + A   +P +   +  S       E        S   E+     +   
Sbjct: 4779 STTHTISSPPSTTSALVEEPTSYHSSPGSIATTHFPESS----TTSGRSEESTASHSSPD 4834

Query: 933  NNGPFGQDKNIAMTGQIT-STKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAI 991
             NG      +   +G+I  ST    + G    T      +   TP  ++ +TI  +++  
Sbjct: 4835 TNGITPLPAHFTTSGRIAESTTFYISPGSMETTL----ASTATTPGLSAKSTILYSSSRS 4890

Query: 992  ATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSS 1038
               T++  ++ +++++   T+  +   +T T +   ST T+GL   S
Sbjct: 4891 PDQTLSPASMTSSSISGEPTSLYSQAESTHTTAFPASTTTSGLSQES 4937



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 193/935 (20%), Positives = 311/935 (33%), Gaps = 118/935 (12%)

Query: 154  KSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESN 213
            +S P     S   +T L    +  P+  +  T   +  +  D  + PA     G  EES+
Sbjct: 2494 ESTPSRLSPSSTETTTLPGSPT-TPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESS 2552

Query: 214  PSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSS---------- 263
             S    S P S+   AF +   + +P  S  +  +  SP    + L P+S          
Sbjct: 2553 TS---HSQPGSTHTTAFPD--STTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQES 2607

Query: 264  -------GLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFG 316
                   G +     PG     S GQ+  T +  P          S T    +E      
Sbjct: 2608 TTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVH 2667

Query: 317  NLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSL---PSDPSCVEEILREMT--HSWP-- 369
            + +        P++++S     + T  QT   S    PS PS     + E T  H  P  
Sbjct: 2668 SSTGSPRTTLSPASSTSPGLQGESTTFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGS 2727

Query: 370  TPLT----SMHTAGHSEQSTFSIPGQESQHLTP----GFTLQKWNDPTTRASTKSVSFK- 420
            TP T    S  T+GHSE+ST      ++   TP      T  +    T+R S  S     
Sbjct: 2728 TPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITT 2787

Query: 421  ---SMLEDDLKLSSDEDDLEPVKTLTTQCTA--TELYQAVEKAKPRNNPVNPPLATPQPP 475
               S     L  +S      P    TT   A  T L    E    R+ P +    +   P
Sbjct: 2788 LPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGS--THSTVSP 2845

Query: 476  PAVQASGGSGSSSESESSSESDSDT---ESSTTDSESNEAPRVATPEPEPPSTNKWQLDK 532
             +    G S  S+   SSS   ++T     STT S   E P      P    T  +  D 
Sbjct: 2846 ASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPASTHTTLFTEDS 2905

Query: 533  WLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT-----NASQVPAEPKERP 587
              + +T ++ +F      +P  T +  P  +   ++  +  T      ++     P    
Sbjct: 2906 TTSGLTEESTAF----PGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARST 2961

Query: 588  LLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPK 647
               L+ E    R +    ET  L     TT     + T     P+  +   S        
Sbjct: 2962 TSGLVGESTPSRLSPSSTETTTLPGS-PTTPSLSEKSTTFYTSPRSPDATLS-------- 3012

Query: 648  PNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKS 707
            P  T+S+   +ES   H  P G    TA   +         P A    +      + P S
Sbjct: 3013 PATTTSSGVSEESSTSHSQP-GSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSPGS 3071

Query: 708  --REFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGS 765
                 +   S+T  S+    ET    +LP   I+ G    S     ++ +L T ++ + S
Sbjct: 3072 TTASSLGQQSTTFHSSPGDTET---TLLPDDTITSGLVEASTPTHSSTGSLHTTLTPA-S 3127

Query: 766  NNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAK 825
            + +  +  E  TF   P       SP           V++          HS   + P  
Sbjct: 3128 STSAGLQEESTTFQSWPSSSDTTPSP----PGTTAAPVEVSTTY------HSRPSSTPTT 3177

Query: 826  PDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCIS 885
                 + T  + + + T    P   G             P +      AT++ +  P  S
Sbjct: 3178 HFSASSTTLGRSEESTTVHSSPGATG---------TALFPTR-----SATSVLVGEPTTS 3223

Query: 886  PAPPHKPPNTRENNSSRRAN-RRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIA 944
            P        T    S+  A    K    +  P SP     P     SG            
Sbjct: 3224 PISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSG------------ 3271

Query: 945  MTGQITSTKPKRTEGKFCATFKGISVNEGDTPKK-ASSATITVTNTAIATATVTATAIVT 1003
               + ++T   R        F G +   G + +  AS ++   T+T ++  + TA+++  
Sbjct: 3272 -VSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGP 3330

Query: 1004 TTVTATATATATTTTTTTTISTITSTITTGLMDSS 1038
             + T  +   +T TT         +T  +GL+++S
Sbjct: 3331 ESTTFHSGPGSTETTLLP-----DNTTASGLLEAS 3360



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 185/889 (20%), Positives = 294/889 (33%), Gaps = 117/889 (13%)

Query: 200  PAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLL 259
            PA     G  EES  S    S P S+   AF +   + +P  S  +  +  SP    + L
Sbjct: 982  PASTTSSGVSEESTTSR---SRPGSTHTTAFPD--STTTPGLSRHSTTSHSSPGSTDTTL 1036

Query: 260  AP-----------------SSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDIS 302
             P                 SSG +     PG     S GQ+  T +  P          S
Sbjct: 1037 LPASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDS 1096

Query: 303  PTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSL---PSDPSCVEE 359
             T    +E      + +        P++++S     + T  QT   S    PS PS    
Sbjct: 1097 TTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATA 1156

Query: 360  ILREMT--HSWP--TPLT----SMHTAGHSEQSTFSIPGQESQHLTP----GFTLQKWND 407
             + E T  H  P  TP T    S  T+GHSE+ST      ++   TP      T  +   
Sbjct: 1157 PVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGES 1216

Query: 408  PTTRASTKSVSFK----SMLEDDLKLSSDEDDLEPVKTLTTQCTA--TELYQAVEKAKPR 461
             T+R S  S        S     L  +S      P    TT   A  T L    E    R
Sbjct: 1217 TTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSR 1276

Query: 462  NNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDT---ESSTTDSESNEAPRVATP 518
            + P +    +   P +    G S  S+   SSS   ++T     STT S   E P     
Sbjct: 1277 SQPGS--THSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTFHS 1334

Query: 519  EPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT---- 574
             P    T  +  D   + +T ++ +F      +P  T +  P  +   ++  +  T    
Sbjct: 1335 RPASTHTTLFTEDSTTSGLTEESTAF----PGSPASTQTGLPATLTTADLGEESTTFPSS 1390

Query: 575  -NASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKK 633
              ++     P       L+ E    R +    ET  L     TT     + T     P+ 
Sbjct: 1391 SGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGS-PTTPSLSEKSTTFYTSPRS 1449

Query: 634  VEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPE 693
             +   S        P  T+S+   +ES   H  P G    TA   +         P    
Sbjct: 1450 PDATLS--------PATTTSSGVSEESSTSHSQP-GSTHTTAFPDSTTTSDLSQEPTTSH 1500

Query: 694  KKKYRGPGKIVPKS--REFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG 751
              +      + P S     +   S+T  S+    ET    +LP   I+ G    S     
Sbjct: 1501 SSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTET---TLLPDDTITSGLVEASTPTHS 1557

Query: 752  ASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLS 811
            ++ +L T ++ + S+ +  +  E  TF   P       SP           V++      
Sbjct: 1558 STGSLHTTLTPA-SSTSAGLQEESTTFQSWPSSSDTTPSP----PGTTAAPVEVSTTY-- 1610

Query: 812  RVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRL 871
                HS   + P       + T  + + + T    P   G             P +    
Sbjct: 1611 ----HSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGATG---------TALFPTR---- 1653

Query: 872  EEATTICLLPPCISPAPPHKPPNTRENNSSRRAN-RRKEEKLFPPPLSPLPEDPPRRRNV 930
              AT++ +  P  SP        T    S+  A    K    +  P SP     P     
Sbjct: 1654 -SATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTS 1712

Query: 931  SGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKK-ASSATITVTNT 989
            SG               + ++T   R        F G +   G + +  AS ++   T+T
Sbjct: 1713 SG-------------VSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDT 1759

Query: 990  AIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSS 1038
             ++  + TA+++   + T  ++  +T TT         +T  +GL+++S
Sbjct: 1760 TLSPGSTTASSLGPESTTFHSSPGSTETTLLP-----DNTTASGLLEAS 1803



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 186/892 (20%), Positives = 297/892 (33%), Gaps = 123/892 (13%)

Query: 200  PAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLL 259
            PA     G  EES  S    S P S+   AF +   + +P  S  +  +  SP    + L
Sbjct: 3622 PASTTSSGVSEESTTS---HSRPGSTHTTAFPD--STTTPGLSRHSTTSHSSPGSTDTTL 3676

Query: 260  AP-----------------SSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDIS 302
             P                 SSG +     PG     S GQ+  T +  P          S
Sbjct: 3677 LPASTTTSGSSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDS 3736

Query: 303  PTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSL---PSDPSCVEE 359
             T    +E      + +        P++++S     + T  QT   S    PS PS    
Sbjct: 3737 TTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATA 3796

Query: 360  ILREMT--HSWP--TPLT----SMHTAGHSEQSTFSIPGQESQHLTP----GFTLQKWND 407
             + E T  H  P  TP T    S  T+GHSE+ST      ++   TP      T  +   
Sbjct: 3797 PVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGES 3856

Query: 408  PTTRASTKSVSFK----SMLEDDLKLSSDEDDLEPVKTLTTQCTA--TELYQAVEKAKPR 461
             T+R S  S        S     L  +S      P    TT   A  T L    E    R
Sbjct: 3857 TTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSR 3916

Query: 462  NNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDT---ESSTTDSESNEAPRVATP 518
            + P +    +   P +    G S  S+   SSS   ++T     STT S   E P     
Sbjct: 3917 SQPGS--THSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRREEPTTFHS 3974

Query: 519  EPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT---- 574
             P    T  +  D   + +T ++ +F      +P  T +  P  +   ++  +  T    
Sbjct: 3975 RPASTHTTLFTEDSTTSGLTEESTAF----PGSPASTQTGLPATLTTADLGEESTTFPSS 4030

Query: 575  -NASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKK 633
              ++     P       L+ E    R +    ET  L     TT     + T     P+ 
Sbjct: 4031 SGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGS-PTTPSLSEKSTTFYTSPRS 4089

Query: 634  VEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAP-----RKEPRPNI 688
             +   S        P  T+S+   +ES   H  P G    TA   +       +EP  + 
Sbjct: 4090 PDATLS--------PATTTSSGVSEESSTSHSQP-GSTHTTAFPDSTTTSGLSQEPTTSH 4140

Query: 689  PLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKE 748
                  +    PG     S   +   S+T  S+    ET    +LP   I+ G    S  
Sbjct: 4141 SSQGSTEATLSPGSTTASS---LGQQSTTFHSSPGDTET---TLLPDDTITSGLVEASTP 4194

Query: 749  ICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLD 808
               ++ +L T ++ + S+ +  +  E  TF   P       SP           V +++ 
Sbjct: 4195 THSSTGSLHTTLTPA-SSTSTGLQEESTTFQSWPSSSDTTPSP------PSTTAVPVEVS 4247

Query: 809  LLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKK 868
                   HS   + P       + T  + + + T    P   G             P + 
Sbjct: 4248 ----TTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGATG---------TALFPTR- 4293

Query: 869  QRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRAN-RRKEEKLFPPPLSPLPEDPPRR 927
                 AT++ +  P  SP        T    S+  A    K    +  P SP     P  
Sbjct: 4294 ----SATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPAS 4349

Query: 928  RNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKK-ASSATITV 986
               SG               + ++T   R        F   +   G + +  AS ++   
Sbjct: 4350 TTSSG-------------VSEESTTSHSRPGSMHTTAFPSSTTMPGVSQESTASHSSPGS 4396

Query: 987  TNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSS 1038
            T+T ++  + TA+++   + T  ++  +T TT         +T  +GL+++S
Sbjct: 4397 TDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLP-----DNTTASGLLEAS 4443



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 151/691 (21%), Positives = 229/691 (33%), Gaps = 89/691 (12%)

Query: 154  KSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESN 213
            +S P     S   +T L    +  P+  +  T   +  +  D  + PA     G  EES+
Sbjct: 2968 ESTPSRLSPSSTETTTLPGSPT-TPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESS 3026

Query: 214  PSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPG 273
             S    S P S+   AF +   ++   +   A  +             S G +     PG
Sbjct: 3027 TS---HSQPGSTHTTAFPDSTTTSGLSQEPTASHS-------------SQGSTEATLSPG 3070

Query: 274  LYCKTSMGQQKPTAYVRPMDGQDQA-PDISPT---LKPSIEFENSFGNLSFGTLLDGKPS 329
                +S+GQQ  T +  P D +    PD + T   ++ S    +S G+L   TL     +
Sbjct: 3071 STTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHT-TLTPASST 3129

Query: 330  AASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMT--HSWPTPLTSMH------TAGHS 381
            +A  + +   F    +S  + PS P      +   T  HS P+   + H      T G S
Sbjct: 3130 SAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRS 3189

Query: 382  EQST--FSIPGQESQHLTP--GFTLQKWNDPTTR----ASTKSVSFK-SMLEDDLKLSSD 432
            E+ST   S PG     L P    T     +PTT      ST++ +   S     L   S 
Sbjct: 3190 EESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKST 3249

Query: 433  EDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESES 492
                 P    TT   A+     V +    ++       T   P +    G S  S+ S S
Sbjct: 3250 TFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHS 3309

Query: 493  SSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQL-DKWLNKVTSQNKSFICGQNET 551
            S  S   T S  + + S+  P   T    P ST    L D        +  + +     +
Sbjct: 3310 SPGSTDTTLSPGSTTASSLGPESTTFHSGPGSTETTLLPDNTTASGLLEASTPVHSSTGS 3369

Query: 552  PMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALK 611
            P  T+S      +  E      T     P      P        A P  T    E     
Sbjct: 3370 PHTTLSPAGSTTRQGE-----STTFQSWPNSKDTTP--------APPTTTSAFVELSTTS 3416

Query: 612  H----KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPP 667
            H       TT  + S  T+G+ +      ++     T P P  ++++   +ES   H  P
Sbjct: 3417 HGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSP 3476

Query: 668  ----------------RGRNKATAHKPAPR---KEPRPNIPLAPEKKKYR-GPGKIVPKS 707
                            RG    T+H          P     L  E   Y   PG      
Sbjct: 3477 GSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTH 3536

Query: 708  REFIETDSSTSDSNT---DQEETLQIKVLP----PCIISGGNTAKSKEICGASLTLSTLM 760
                 T S  S+ +T     ++     VLP      ++ G +T  +  I   S+  + L 
Sbjct: 3537 FPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGEST--TSPISSGSMETTAL- 3593

Query: 761  SSSGSNNNLSISNEEPTFSPIPVMQTEILSP 791
               GS     +S +  TF   P      LSP
Sbjct: 3594 --PGSTTTPGLSEKSTTFHSSPRSPATTLSP 3622



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 153/691 (22%), Positives = 232/691 (33%), Gaps = 89/691 (12%)

Query: 154  KSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESN 213
            +S P     S   +T L    +  P+  +  T   +  +  D  + PA     G  EES+
Sbjct: 1411 ESTPSRLSPSSTETTTLPGSPT-TPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESS 1469

Query: 214  PSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPG 273
             S    S P S+   AF +     S   S+ + +    P  + S    S G +     PG
Sbjct: 1470 TS---HSQPGSTHTTAFPD-----STTTSDLSQE----PTTSHS----SQGSTEATLSPG 1513

Query: 274  LYCKTSMGQQKPTAYVRPMDGQDQA-PDISPT---LKPSIEFENSFGNLSFGTLLDGKPS 329
                +S+GQQ  T +  P D +    PD + T   ++ S    +S G+L   TL     +
Sbjct: 1514 STTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHT-TLTPASST 1572

Query: 330  AASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMT--HSWPTPLTSMH------TAGHS 381
            +A  + +   F    +S  + PS P      +   T  HS P+   + H      T G S
Sbjct: 1573 SAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRS 1632

Query: 382  EQST--FSIPGQESQHLTP--GFTLQKWNDPTTR----ASTKSVSFK-SMLEDDLKLSSD 432
            E+ST   S PG     L P    T     +PTT      ST++ +   S     L   S 
Sbjct: 1633 EESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKST 1692

Query: 433  EDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESES 492
                 P    TT   A+     V +    ++       T   P +    G S  S+ S S
Sbjct: 1693 TFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHS 1752

Query: 493  SSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQL-DKWLNKVTSQNKSFICGQNET 551
            S  S   T S  + + S+  P   T    P ST    L D        +  + +     +
Sbjct: 1753 SPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGS 1812

Query: 552  PMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALK 611
            P  T+S      +  E      T     P+     P        A P  T    E     
Sbjct: 1813 PHTTLSPAGSTTRQGE-----STTFQSWPSSKDTMP--------APPTTTSAFVELSTTS 1859

Query: 612  H----KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPP 667
            H       TT  + S  T+G+ +      ++     T P P  ++++   +ES   H  P
Sbjct: 1860 HGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSP 1919

Query: 668  ----------------RGRNKATAHKPAPR---KEPRPNIPLAPEKKKYR-GPGKIVPKS 707
                            R     T+H          P     L  E   Y   PG      
Sbjct: 1920 GSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTATTH 1979

Query: 708  REFIETDSSTSDSNT---DQEETLQIKVLP----PCIISGGNTAKSKEICGASLTLSTLM 760
                 T S  S+ +T     ++     VLP      ++ G +T  +  I   S+  + L 
Sbjct: 1980 FPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGEST--TSPISSGSMETTAL- 2036

Query: 761  SSSGSNNNLSISNEEPTFSPIPVMQTEILSP 791
               GS     +S +  TF   P      LSP
Sbjct: 2037 --PGSTTTPGLSEKSTTFHSSPRSPATTLSP 2065



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 183/904 (20%), Positives = 295/904 (32%), Gaps = 163/904 (18%)

Query: 200  PAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLL 259
            PA     G  EES  S    S P S+   AF +   + +P  S  +  +  SP    + L
Sbjct: 2065 PASTTSSGVSEESTTS---HSRPGSTHTTAFPD--STTTPGLSRHSTTSHSSPGSTDTTL 2119

Query: 260  APSS-----------------GLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDIS 302
             P+S                 G +     PG     S GQ+  T +  P          S
Sbjct: 2120 LPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDS 2179

Query: 303  PTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSL---PSDPSCVEE 359
             T    +E      + +        P++++S     + T  QT   S    PS PS    
Sbjct: 2180 TTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATA 2239

Query: 360  ILREMT--HSWP--TPLT----SMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTR 411
             + E T  H  P  TP T    S  T+GHSE+ST      ++   TP          TT 
Sbjct: 2240 PVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSA-----HSTTS 2294

Query: 412  ASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCT--ATELYQAVEKAKPRNNPVN-PP 468
               +S + +      +   S E    P  T T   +  +T  Y +        +P +   
Sbjct: 2295 GRGESTTSR------ISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTS 2348

Query: 469  LATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTN-K 527
            L   +     ++  GS  S+ S +S+ +   +E STT   S+      T  P  P+T+ +
Sbjct: 2349 LGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRTPTTSVR 2408

Query: 528  WQLDKWLNKVTSQNKSFICGQNETPM----ETISLPPPIIQPMEVQMKVKTNASQVPAEP 583
             +     +   +   + +  ++ T      E+ + P     P   Q  +    +      
Sbjct: 2409 GEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPG---SPASTQTGLPATLTTAD--- 2462

Query: 584  KERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNT----- 638
                    + E++   P+        L    STTS  V + T  +  P   E  T     
Sbjct: 2463 --------LGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSP 2514

Query: 639  --------STDEFTWPK-------PNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKE 683
                    ST  +T P+       P  T+S+   +ES   H  P G    TA        
Sbjct: 2515 TTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQP-GSTHTTAF------- 2566

Query: 684  PRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNT 743
              P+    P   ++       P S +     +ST+ S   QE T           S G+T
Sbjct: 2567 --PDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHS-------SPGST 2617

Query: 744  AKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWV 803
              +               S GS   LS   E  TF   P      L P  D      +  
Sbjct: 2618 DTA--------------LSPGSTTALSFGQESTTFHSSPGSTHTTLFP--DSTTSSGI-- 2659

Query: 804  KIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEK 863
               ++  +RV  HSS   +P       ++T P  Q   T  +           P   A  
Sbjct: 2660 ---VEASTRV--HSST-GSPRTTLSPASSTSPGLQGESTTFQTHPASTHTTPSPPSTA-- 2711

Query: 864  IPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPED 923
                   +EE+TT            P   P T    SS  +   ++  +F          
Sbjct: 2712 ----TAPVEESTTY--------HRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTT 2759

Query: 924  PPRRRNVSGNNGPFGQDKNIAMTGQIT-----STKPKRTEGKFC--------------AT 964
            P    + +   G     +    + +IT     +T P  +E                  A+
Sbjct: 2760 PSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPAS 2819

Query: 965  FKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTIS 1024
               + V E  T  ++   +   T++ ++ A+ T   +   + T  +++  +T TT    S
Sbjct: 2820 MTSLGVGEESTTSRSQPGS---THSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRS 2876

Query: 1025 TITS 1028
            T TS
Sbjct: 2877 TTTS 2880



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 59/240 (24%), Positives = 85/240 (35%), Gaps = 15/240 (6%)

Query: 299 PDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLP-SDPSCV 357
           P  SP    S+E     G+ +   L + K +   S  + P  T+      S   S+ S  
Sbjct: 252 PKTSPITSASMETTALPGSTTTAGLSE-KSTTFYSSPRSPDRTLSPARTTSSGVSEKSTT 310

Query: 358 EEILREMTHSWPTP-LTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDP--TTRAST 414
                  TH+   P  T+M        ++ SIPG     L+PG T      P  TT  S+
Sbjct: 311 SHSRPGPTHTIAFPDSTTMPGVSQESTASHSIPGSTDTTLSPGTTTPSSLGPESTTFHSS 370

Query: 415 KSVSFKSMLEDDLKLSSDEDDLEPVKTLT--TQCTATELYQAVEKAKPRNNPVNPPLATP 472
              +  + L D+   S   +   PV + T     T +       + +P      P     
Sbjct: 371 PGYTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSPSSSTTHEGEPTTFQSWPSSKDT 430

Query: 473 QPPPAVQASGGSGSSSESESSSESDSDTE---SSTTDSESNE-----APRVATPEPEPPS 524
            P P+   S     S+   SS  S   T    SSTT   S E     +  VAT    PP+
Sbjct: 431 SPAPSGTTSAFVKLSTTYHSSPSSTPTTHFSASSTTLGHSEESTPVHSSPVATATTPPPA 490


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical
            region 1 [Homo sapiens]
          Length = 1400

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 149/744 (20%), Positives = 246/744 (33%), Gaps = 95/744 (12%)

Query: 362  REMTHSWPTPLTSMHTAGHSE----QSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSV 417
            REMT +  T L       H E    ++T   P + ++H     T  +   P+    T+  
Sbjct: 408  REMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHGER--TANENTTPSPAEPTEHG 465

Query: 418  SFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPA 477
                   D    SS E      +T       T        A+P  N          P PA
Sbjct: 466  ERTPFANDKTTSSSAESTEHGERTPLANENTTP-----SPAEPTENRERTANENTTPSPA 520

Query: 478  VQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKV 537
                    +++E  + S  +      TT +E        TP P  P+ N  +      K 
Sbjct: 521  GPTENRETTANEKTTLSPVEPTENRETTANEKT------TPSPAEPTENGQRTPFANEKT 574

Query: 538  TSQNKSFICGQNETPMETISLPPPIIQPMEVQMKV---KTNASQVPAEPKER-PLLSLIR 593
            TS +         TP+   +  P   +P E + +    KT  S  PAEP E      L  
Sbjct: 575  TSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPS--PAEPTENGDRTPLAN 632

Query: 594  EKARP---RPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNT------------ 638
            EK  P    PT+    T     K  TTS +       ++ P   E  T            
Sbjct: 633  EKTTPSLAEPTENGQRTPFANEK--TTSSSAEPTEHEERTPLANENTTPSPAEPTENRER 690

Query: 639  STDEFTWPKP----NITSSTPKEKESVELHDPPRGR----NKATAHKPAPRKEPRPNIPL 690
            + +E T P P         T  EK ++   +P   R    N+ T   PA   E     P 
Sbjct: 691  TANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPF 750

Query: 691  APEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEIC 750
            A EK                    +S+S   T+  E   +      +   G T   +   
Sbjct: 751  ANEKT-------------------TSSSAEPTEHGERTPLANENTTLSPAGPTENRERTA 791

Query: 751  GASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLL 810
                  +T   +  + N    +NE  T SP    +    +PL + +   +L    +    
Sbjct: 792  NEK---TTPFPAEPTENRERTANENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKR 848

Query: 811  SRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQR 870
            +      +  ++    +H E        T  +  E   P   R+    E   + P +   
Sbjct: 849  TPFANEKTTSSSAEPTEHAERTPLANENTTSSPAE---PTENRERTANEKTTQFPAEPTE 905

Query: 871  LEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNV 930
              E+T      P  +    ++     EN +   A   + E++ P  +    + P R+ + 
Sbjct: 906  NRESTANEKTTPFPAEPTENREWTANENTTLSPAEPTEHEEMTPLMVDENLQAPFRQGSC 965

Query: 931  SGNNGPFGQDKNIAMTGQITSTKPKRTEGKFC-ATFKGISVNEGDTPKKA------SSAT 983
            +       + K+I  T   T+     T  +   ++   +S     T          SSA 
Sbjct: 966  AE------RPKDICATVASTTGSESSTASEIITSSTMSVSATASSTASSTASEITMSSAA 1019

Query: 984  ITVTNTAIATAT--------VTATAI-VTTTVTATATATATTTTTTTTISTITSTITTGL 1034
            I V++TA  T          VTA+ + + +T+  T  +  TT++T T++ T  ST  +  
Sbjct: 1020 IPVSSTAYETIRFSTAVSEPVTASILALESTLAFTTVSNTTTSSTVTSVPTTASTSGSKN 1079

Query: 1035 MDSSHLEMTSWAALPLLSSSSTNV 1058
              +    M+      + +S  T V
Sbjct: 1080 TTACEATMSETTIAAITASEDTTV 1103



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 180/931 (19%), Positives = 317/931 (34%), Gaps = 113/931 (12%)

Query: 185  TQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEF 244
            T+++     E+  ++PAE  + GE   +  +    + P   GE    E    +  E +E 
Sbjct: 405  TENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEH 464

Query: 245  AVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPT-AYVRPMDGQDQAPDISP 303
              + P     A+     SS  S ++       +T +  +  T +   P + +++  + + 
Sbjct: 465  GERTP----FANDKTTSSSAESTEHGE-----RTPLANENTTPSPAEPTENRERTANENT 515

Query: 304  TLKPSIEFENSFGNLSFGTLL------DGKPSAASSKTKLPKFTILQTSEVSLPSDPSCV 357
            T  P+   EN     +  T L      + + + A+ KT        +  + +  ++    
Sbjct: 516  TPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTT 575

Query: 358  EEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWN-DPTTRASTKS 416
                    H   TPL + +T     + T +     ++  TP       N D T  A+ K+
Sbjct: 576  SSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKT 635

Query: 417  VSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPP 476
                      L   ++     P     T  ++ E  +  E+    N    P  A P    
Sbjct: 636  TP-------SLAEPTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTPSPAEPTENR 688

Query: 477  AVQASGGSGSSSESESSSESDSDTESST------TDSESNEAPRVATPEPEPPSTNKWQL 530
               A+  +  S    + +   +  E +T      T++    A    T  P  P+ N  + 
Sbjct: 689  ERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRT 748

Query: 531  DKWLNKVTSQNKSFICGQNETPM--ETISLPPPIIQPMEVQMKVKTN-ASQVPAEPKERP 587
                 K TS +         TP+  E  +L P    P E + +      +  PAEP E  
Sbjct: 749  PFANEKTTSSSAEPTEHGERTPLANENTTLSPA--GPTENRERTANEKTTPFPAEPTENR 806

Query: 588  LLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTI-GKKQPKKVEKNTST------ 640
              +   E   P P Q              T+ ++++ T  GK+ P   EK TS+      
Sbjct: 807  ERTA-NENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTE 865

Query: 641  --DEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYR 698
              +       N TSS  +  E+ E     R  N+ T   PA   EP  N      +K   
Sbjct: 866  HAERTPLANENTTSSPAEPTENRE-----RTANEKTTQFPA---EPTENRESTANEKTTP 917

Query: 699  GPGKIVPKSREFIETDSSTSD--SNTDQEETLQIKV---LPPCIISGGNTAKSKEICGAS 753
             P +   ++RE+   +++T      T+ EE   + V   L      G    + K+IC   
Sbjct: 918  FPAEPT-ENREWTANENTTLSPAEPTEHEEMTPLMVDENLQAPFRQGSCAERPKDICATV 976

Query: 754  --------------LTLSTLMSSSGSNNNLSISNEEPTFSP--IPVMQTEILSPLRDHEN 797
                          +T ST+  S+ +++  S +  E T S   IPV  T           
Sbjct: 977  ASTTGSESSTASEIITSSTMSVSATASSTASSTASEITMSSAAIPVSSTA---------- 1026

Query: 798  LKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKP 857
                +  I        P  +S+ A  +       +      T  +     +  G +    
Sbjct: 1027 ----YETIRFSTAVSEPVTASILALESTLAFTTVSNTTTSSTVTSVPTTASTSGSKNTTA 1082

Query: 858  IE--VAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPP 915
             E  ++E         E+ T         + + PH    T  + ++   +    +     
Sbjct: 1083 CEATMSETTIAAITASEDTTVSTQTSVIAAESVPHTATKTPTDTTTASVSATVPKNNTLS 1142

Query: 916  PLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDT 975
             ++  P   P   +         +    A     TST        F  T K  + +E  T
Sbjct: 1143 VITSTPSTAPNTAS---------KTMTTASKTTTTSTITSLPTTVFTTTSKITAGSEIPT 1193

Query: 976  PKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTT--------TISTIT 1027
                 SAT  ++  A  T   +A +    T   T TA+  TTT+TT        T+S++ 
Sbjct: 1194 ASTTDSATTAISTKASGTTVESAPSTAPPTPAETTTASVPTTTSTTGSENTGHHTVSSVP 1253

Query: 1028 STITTGLMDSSHLEMTSWAALPLLSSSSTNV 1058
            +T+     +SS    T+ A     S+S+T V
Sbjct: 1254 TTVFATASESSTGSETTRA-----STSATEV 1279


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 94/392 (23%), Positives = 150/392 (38%), Gaps = 64/392 (16%)

Query: 391 QESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATE 450
           +E Q   P   +QK   P  +A+ K+   K+   D    SS ED  EP K    + T   
Sbjct: 138 EEDQKKQP---VQKGVKPQAKAA-KAPPKKAKSSDSDSDSSSED--EPPKNQKPKITPVT 191

Query: 451 LYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESN 510
           + +A  KA P+     P +A  +       +  S SSS S SSS+   + +++ T  ++ 
Sbjct: 192 V-KAQTKAPPKPARAAPKIANGK-------AASSSSSSSSSSSSDDSEEEKAAATPKKTV 243

Query: 511 EAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMET-----ISLPPPIIQP 565
              +V    P   +T   +        +S  +     + + PM+       S+PPP   P
Sbjct: 244 PKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE----EQKKPMKNKPGPYSSVPPPSAPP 299

Query: 566 ----MEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETV 621
               +  Q   K    Q P E  E        E       +K P TKA+  K +T     
Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSE----DSSDESDSSSEEEKKPPTKAVVSKATT----- 350

Query: 622 SQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPR 681
                 K  P K    +S+D          SS     E  E    P G  K +++KPA  
Sbjct: 351 ------KPPPAKKAAESSSD----------SSDSDSSEDDEAPSKPAGTTKNSSNKPAVT 394

Query: 682 KEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGG 741
            +     P A  K+   G  K++ +     ++ SS  +S++ +EE  +  V         
Sbjct: 395 TKSPAVKPAAAPKQPVGGGQKLLTRK---ADSSSSEEESSSSEEEKTKKMVA-------- 443

Query: 742 NTAKSKEICGASLTLSTLMSSSGSNNNLSISN 773
            T K K    A+L+L    +  GS ++ S S+
Sbjct: 444 -TTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 130/647 (20%), Positives = 230/647 (35%), Gaps = 121/647 (18%)

Query: 172 SQASGQPNKMQTLT----QDQSQAKLEDFFVYPAEQPQIGE--VEESNPSAKEDSNPNSS 225
           +Q S   NK    T    QD + + L D + +  +  ++ E  ++ + P AK+       
Sbjct: 25  NQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKK------- 77

Query: 226 GEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKP 285
              A K+   S+S + SE   +  G P   +++ A   GL     PPG     +      
Sbjct: 78  ---AKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL-----PPGKAAAKASESSSS 129

Query: 286 TAYVRPMDGQDQAPD-ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASS--KTKLPKFT- 341
                  D +DQ    +   +KP  +   +    +  +  D   S+     K + PK T 
Sbjct: 130 EESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITP 189

Query: 342 ILQTSEVSLPSDPS-CVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGF 400
           +   ++   P  P+    +I      S  +  +S  ++  SE+        E    TP  
Sbjct: 190 VTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEE--------EKAAATPKK 241

Query: 401 TLQKWN---DPTTRASTKSVSFKSMLEDDLKLSSDEDDLE-------------------- 437
           T+ K         +A+T      S  ED    SSDE++ +                    
Sbjct: 242 TVPKKQVVAKAPVKAATTPTRKSSSSEDS---SSDEEEEQKKPMKNKPGPYSSVPPPSAP 298

Query: 438 -PVKTLTTQCT--ATELYQAVEKAKPRNNPVN--------PPL------ATPQPPPAVQA 480
            P K+L TQ    A E  Q VE ++  ++  +        PP       AT +PPPA +A
Sbjct: 299 PPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKA 358

Query: 481 SGGSGSSSESE--SSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQ-------LD 531
           +  S  SS+S+     E+ S    +T +S +  A    +P  +P +  K         L 
Sbjct: 359 AESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLT 418

Query: 532 KWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVK-----------TNASQVP 580
           +  +  +S+ +S    + +T     +  P       + +  K            + S   
Sbjct: 419 RKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSS 478

Query: 581 AEPKERPLLSLIREK----------ARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQ 630
            E +E+   S +++K          ++P   +K     +       +SE   ++  GK  
Sbjct: 479 EEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGS 538

Query: 631 PK-KVEKNTSTDEFTWPKPNITSSTPKEKE---------SVELHDPPRGRNKATAHKPAP 680
           P+ +  K   T   T        ++ +E+E         S       R +N+A      P
Sbjct: 539 PRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETP 598

Query: 681 R----KEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTD 723
           +    K   PN     +K + R          E IE DS  +D++ D
Sbjct: 599 QAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFD 645



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 115/591 (19%), Positives = 205/591 (34%), Gaps = 96/591 (16%)

Query: 628  KKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPN 687
            K   +K++ N    +    K + + S    +E  E+  PP       A K A        
Sbjct: 62   KVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPP-------AKKAA-------- 106

Query: 688  IPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTD--QEETLQIKVLPPCIISGGNTAK 745
                P K+    PGK   K+ E   ++ S+ D + +  +++ +Q  V P    +     K
Sbjct: 107  ---VPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKK 163

Query: 746  SKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKI 805
            +K         S+   S  S+ +    N++P  +P+ V       P       K    K 
Sbjct: 164  AK---------SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKA 214

Query: 806  DLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVA---E 862
                 S     SS  +   K       T PK+Q    A  K A    RK    E +   E
Sbjct: 215  ASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDE 274

Query: 863  KIPEKKQRLEEATTICLLPPCISPAP--------------PHKPPNTRENNSSRRANRRK 908
            +  +KK    +      +PP  +P P                +P  + E++S    +  +
Sbjct: 275  EEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSE 334

Query: 909  EEK------------LFPPPLSPLPE------DPPRRRNVSGNNGPFGQDKNI----AMT 946
            EEK              PPP     E      D     +    + P G  KN     A+T
Sbjct: 335  EEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVT 394

Query: 947  GQITSTKPKRTEGKFCATFKGISVNEGD---TPKKASSATITVTNTAIATATVTATAIVT 1003
             +  + KP     +     + +   + D   + +++SS+    T   +AT    ATA   
Sbjct: 395  TKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAA 454

Query: 1004 TTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKL 1063
             ++ A      +  +++ + S+ +         S+  +     A     S   + ++ K 
Sbjct: 455  LSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKA 514

Query: 1064 TFDDSVHNADYYMQEAKKLKHK------------ADALFEKFGKAVNYAD--------AA 1103
               +S  + D   +E +KLK K              AL  + GKA   ++        AA
Sbjct: 515  ESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA 574

Query: 1104 LSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKK 1154
            +  ++ G+  +R   EA       +ET +  +  ++  N   P    G+K+
Sbjct: 575  VVVSKSGSLKKRKQNEAAKE----AETPQAKKIKLQTPN-TFPKRKKGEKR 620


>gi|169167859 PREDICTED: hypothetical protein, partial [Homo sapiens]
          Length = 214

 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 32/85 (37%), Positives = 46/85 (54%)

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSH 1039
            ++ T T T T   T T T T   TTT+T T   T TTTTTTTT +TIT+TITT +  ++ 
Sbjct: 83   TTITTTTTTTITTTTTTTTTITTTTTITTTTITTTTTTTTTTTTTTITTTITTTITTTTI 142

Query: 1040 LEMTSWAALPLLSSSSTNVRRPKLT 1064
               T+   +   ++ +T      +T
Sbjct: 143  TTTTTTTTITTTTTITTTTTTTTIT 167



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 34/87 (39%), Positives = 48/87 (55%), Gaps = 2/87 (2%)

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTI--TSTITTGLMDS 1037
            ++ T T T T I T T T T I TTT T T T T T TTTTTT +TI  T+TITT  + +
Sbjct: 57   TTTTTTTTTTTITTTTTTTTTITTTTTTITTTTTTTITTTTTTTTTITTTTTITTTTITT 116

Query: 1038 SHLEMTSWAALPLLSSSSTNVRRPKLT 1064
            +    T+     + ++ +T +    +T
Sbjct: 117  TTTTTTTTTTTTITTTITTTITTTTIT 143



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 29/53 (54%), Positives = 34/53 (64%)

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITT 1032
            ++ T T+T T I T T T T   TTT+T T T T  TTTTTTTI+T T T TT
Sbjct: 131  TTITTTITTTTITTTTTTTTITTTTTITTTTTTTTITTTTTTTITTSTITTTT 183



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 34/88 (38%), Positives = 42/88 (47%)

Query: 945  MTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTT 1004
            +T   T+T    T      T    ++    T     + T T+T T I T T T T   TT
Sbjct: 68   ITTTTTTTTTITTTTTTITTTTTTTITTTTTTTTTITTTTTITTTTITTTTTTTTTTTTT 127

Query: 1005 TVTATATATATTTTTTTTISTITSTITT 1032
            T+T T T T TTTT TTT +T T T TT
Sbjct: 128  TITTTITTTITTTTITTTTTTTTITTTT 155



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 41/131 (31%), Positives = 60/131 (45%), Gaps = 1/131 (0%)

Query: 926  RRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATIT 985
            +RRN      P     +IA+    T+T    T      T    ++    T    ++ T  
Sbjct: 34   QRRNQIYAPLPNTAGSSIALLLPTTTTTTTTTTTITTTTTTTTTITTTTTTITTTTTTTI 93

Query: 986  VTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSW 1045
             T T   T   T T I TTT+T T T T TTTTTT T +TIT+TITT  + ++    T  
Sbjct: 94   TTTTTTTTTITTTTTITTTTITTTTTTTTTTTTTTIT-TTITTTITTTTITTTTTTTTIT 152

Query: 1046 AALPLLSSSST 1056
                + ++++T
Sbjct: 153  TTTTITTTTTT 163



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 36/87 (41%), Positives = 45/87 (51%), Gaps = 1/87 (1%)

Query: 946  TGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTT 1005
            T  IT+T    T          I+     T    ++ T T+T T   T T T T I TTT
Sbjct: 111  TTTITTTTTTTTTTTTTTITTTITTTITTTTITTTTTTTTITTTTTITTTTTTTTITTTT 170

Query: 1006 VTATATATATTTTTTTTISTITSTITT 1032
             T   T+T TTTTT+TTI+T T+TITT
Sbjct: 171  TTTITTSTITTTTTSTTITT-TTTITT 196



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 40/111 (36%), Positives = 54/111 (48%), Gaps = 4/111 (3%)

Query: 946  TGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTT 1005
            T  IT+T    T      T   I+     T    ++ T T T T   T T+T T I TTT
Sbjct: 90   TTTITTTTTTTTT---ITTTTTITTTTITTTTTTTTTTTTTTITTTITTTITTTTITTTT 146

Query: 1006 VTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSST 1056
             T T T T T TTTTTT +TIT+T TT +  S+    T+   +   ++ +T
Sbjct: 147  TTTTITTTTTITTTTTT-TTITTTTTTTITTSTITTTTTSTTITTTTTITT 196



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 30/76 (39%), Positives = 41/76 (53%)

Query: 981  SATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHL 1040
            + TIT T T     T T T  +TTT T T T T TT TTTTT +  TSTITT    ++  
Sbjct: 130  TTTITTTITTTTITTTTTTTTITTTTTITTTTTTTTITTTTTTTITTSTITTTTTSTTIT 189

Query: 1041 EMTSWAALPLLSSSST 1056
              T+      +++++T
Sbjct: 190  TTTTITTTTTITTTTT 205



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 1/119 (0%)

Query: 946  TGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTT 1005
            T   T T    T      T   I+     T    ++ T T+T T   T T   T   TTT
Sbjct: 63   TTTTTITTTTTTTTTITTTTTTITTTTTTTITTTTTTTTTITTTTTITTTTITTTTTTTT 122

Query: 1006 VTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
             T T T T T TTT TT +TIT+T TT  + ++    T+     + ++++T +    +T
Sbjct: 123  TTTTTTITTTITTTITT-TTITTTTTTTTITTTTTITTTTTTTTITTTTTTTITTSTIT 180



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 28/54 (51%), Positives = 35/54 (64%), Gaps = 1/54 (1%)

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATA-TTTTTTTTISTITSTITT 1032
            ++ TIT T T     T T T I T+T+T T T+T  TTTTT TT +TIT+T TT
Sbjct: 153  TTTTITTTTTTTTITTTTTTTITTSTITTTTTSTTITTTTTITTTTTITTTTTT 206



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 34/102 (33%), Positives = 46/102 (45%)

Query: 943  IAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIV 1002
            I  T  IT+T    T      T          T    ++ T T T T I T T   T   
Sbjct: 103  ITTTTTITTTTITTTTTTTTTTTTTTITTTITTTITTTTITTTTTTTTITTTTTITTTTT 162

Query: 1003 TTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTS 1044
            TTT+T T T T TT+T TTT ++ T T TT +  ++ +  T+
Sbjct: 163  TTTITTTTTTTITTSTITTTTTSTTITTTTTITTTTTITTTT 204



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 27/57 (47%), Positives = 33/57 (57%)

Query: 975  TPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTIT 1031
            T    ++   T T T I T+T+T T   TT  T T   T TT TTTTT +TIT+TIT
Sbjct: 158  TTTTTTTTITTTTTTTITTSTITTTTTSTTITTTTTITTTTTITTTTTTTTITTTIT 214



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 1/91 (1%)

Query: 975  TPKKASSATITVT-NTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTG 1033
            T    ++ TIT T  T I T T+T T   TT  T T   T TTTTT TT +T T T +T 
Sbjct: 120  TTTTTTTTTITTTITTTITTTTITTTTTTTTITTTTTITTTTTTTTITTTTTTTITTSTI 179

Query: 1034 LMDSSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
               ++   +T+   +   ++ +T      +T
Sbjct: 180  TTTTTSTTITTTTTITTTTTITTTTTTTTIT 210



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 26/77 (33%), Positives = 40/77 (51%)

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSH 1039
            ++ TIT T T     T T     TTT T T T T T TT+T T +T ++TITT    ++ 
Sbjct: 138  TTTTITTTTTTTTITTTTTITTTTTTTTITTTTTTTITTSTITTTTTSTTITTTTTITTT 197

Query: 1040 LEMTSWAALPLLSSSST 1056
              +T+      ++++ T
Sbjct: 198  TTITTTTTTTTITTTIT 214



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 29/82 (35%), Positives = 37/82 (45%), Gaps = 1/82 (1%)

Query: 945  MTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTT 1004
            +T  IT+T    T      T          T    ++ T T+T + I T T + T   TT
Sbjct: 133  ITTTITTTTITTTTTTTTITTTTTITTTTTTTTITTTTTTTITTSTITTTTTSTTITTTT 192

Query: 1005 TVTATAT-ATATTTTTTTTIST 1025
            T+T T T  T TTTTT TT  T
Sbjct: 193  TITTTTTITTTTTTTTITTTIT 214



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 17/55 (30%), Positives = 32/55 (58%)

Query: 1004 TTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNV 1058
            +++      T TTTTTTTTI+T T+T TT    ++ +  T+   +   ++++T +
Sbjct: 49   SSIALLLPTTTTTTTTTTTITTTTTTTTTITTTTTTITTTTTTTITTTTTTTTTI 103


>gi|239508976 PREDICTED: mucin 12, cell surface associated [Homo
            sapiens]
          Length = 2036

 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 155/694 (22%), Positives = 235/694 (33%), Gaps = 92/694 (13%)

Query: 154  KSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESN 213
            +S P     S   +T L    +  P+  +  T   +  +  D  + PA     G  EES+
Sbjct: 898  ESTPSRLSPSSTETTTLPGSPT-TPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESS 956

Query: 214  PSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPG 273
             S    S P S+   AF +     S   S+ + +    P  + S    S G +     PG
Sbjct: 957  TS---HSQPGSTHTTAFPD-----STTTSDLSQE----PTTSHS----SQGSTEATLSPG 1000

Query: 274  LYCKTSMGQQKPTAYVRPMDGQDQA-PDISPT---LKPSIEFENSFGNLSFGTLLDGKPS 329
                +S+GQQ  T +  P D +    PD + T   ++ S    +S G+L   TL     +
Sbjct: 1001 STTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHT-TLTPASST 1059

Query: 330  AASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMT--HSWPTPLTSMH------TAGHS 381
            +A  + +   F    +S  + PS P      +   T  HS P+   + H      T G S
Sbjct: 1060 SAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRS 1119

Query: 382  EQST--FSIPGQESQHLTP--GFTLQKWNDPTTR----ASTKSVSFK-SMLEDDLKLSSD 432
            E+ST   S PG     L P    T     +PTT      ST++ +   S     L   S 
Sbjct: 1120 EESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKST 1179

Query: 433  EDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESES 492
                 P    TT   A+     V +    ++       T   P +    G S  S+ S S
Sbjct: 1180 TFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHS 1239

Query: 493  SSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQL-DKWLNKVTSQNKSFICGQNET 551
            S  S   T S  + + S+  P   T    P ST    L D        +  + +     +
Sbjct: 1240 SPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGS 1299

Query: 552  PMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALK 611
            P  T+S      +  E      T     P+     P        A P  T    E     
Sbjct: 1300 PHTTLSPAGSTTRQGE-----STTFQSWPSSKDTMP--------APPTTTSAFVELSTTS 1346

Query: 612  H----KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPP 667
            H       TT  + S  T+G+ +      ++     T P P  ++++   +ES   H  P
Sbjct: 1347 HGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSP 1406

Query: 668  ----------------RGRNKATAHKPAPR---KEPRPNIPLAPEKKKYR-GPGKIVPKS 707
                            R     T+H          P     L  E   Y   PG I    
Sbjct: 1407 GSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTH 1466

Query: 708  REFIETDSSTSDSNT---DQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSG 764
                 T S  S+ +T      +T  I  LP    + G  A+S     +  ++ T ++S+ 
Sbjct: 1467 FPESSTTSGRSEESTASHSSPDTNGITPLPAHFTTSGRIAESTTFYISPGSMETTLASTA 1526

Query: 765  SNNNLSISNE---------EPT---FSPIPVMQT 786
            +   LS  +          EPT    SP P   T
Sbjct: 1527 TTPGLSAKSTILYTSDLVGEPTTFYISPSPTYTT 1560



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 185/889 (20%), Positives = 294/889 (33%), Gaps = 117/889 (13%)

Query: 200  PAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLL 259
            PA     G  EES  S    S P S+   AF +   + +P  S  +  +  SP    + L
Sbjct: 469  PASTTSSGVSEESTTSR---SRPGSTHTTAFPD--STTTPGLSRHSTTSHSSPGSTDTTL 523

Query: 260  AP-----------------SSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDIS 302
             P                 SSG +     PG     S GQ+  T +  P          S
Sbjct: 524  LPASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDS 583

Query: 303  PTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSL---PSDPSCVEE 359
             T    +E      + +        P++++S     + T  QT   S    PS PS    
Sbjct: 584  TTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATA 643

Query: 360  ILREMT--HSWP--TPLT----SMHTAGHSEQSTFSIPGQESQHLTP----GFTLQKWND 407
             + E T  H  P  TP T    S  T+GHSE+ST      ++   TP      T  +   
Sbjct: 644  PVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGES 703

Query: 408  PTTRASTKSVSFK----SMLEDDLKLSSDEDDLEPVKTLTTQCTA--TELYQAVEKAKPR 461
             T+R S  S        S     L  +S      P    TT   A  T L    E    R
Sbjct: 704  TTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSR 763

Query: 462  NNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDT---ESSTTDSESNEAPRVATP 518
            + P +    +   P +    G S  S+   SSS   ++T     STT S   E P     
Sbjct: 764  SQPGS--THSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTFHS 821

Query: 519  EPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT---- 574
             P    T  +  D   + +T ++ +F      +P  T +  P  +   ++  +  T    
Sbjct: 822  RPASTHTTLFTEDSTTSGLTEESTAF----PGSPASTQTGLPATLTTADLGEESTTFPSS 877

Query: 575  -NASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKK 633
              ++     P       L+ E    R +    ET  L     TT     + T     P+ 
Sbjct: 878  SGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGS-PTTPSLSEKSTTFYTSPRS 936

Query: 634  VEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPE 693
             +   S        P  T+S+   +ES   H  P G    TA   +         P    
Sbjct: 937  PDATLS--------PATTTSSGVSEESSTSHSQP-GSTHTTAFPDSTTTSDLSQEPTTSH 987

Query: 694  KKKYRGPGKIVPKS--REFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG 751
              +      + P S     +   S+T  S+    ET    +LP   I+ G    S     
Sbjct: 988  SSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTET---TLLPDDTITSGLVEASTPTHS 1044

Query: 752  ASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLS 811
            ++ +L T ++ + S+ +  +  E  TF   P       SP           V++      
Sbjct: 1045 STGSLHTTLTPA-SSTSAGLQEESTTFQSWPSSSDTTPSP----PGTTAAPVEVSTTY-- 1097

Query: 812  RVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRL 871
                HS   + P       + T  + + + T    P   G             P +    
Sbjct: 1098 ----HSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGATG---------TALFPTR---- 1140

Query: 872  EEATTICLLPPCISPAPPHKPPNTRENNSSRRAN-RRKEEKLFPPPLSPLPEDPPRRRNV 930
              AT++ +  P  SP        T    S+  A    K    +  P SP     P     
Sbjct: 1141 -SATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTS 1199

Query: 931  SGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKK-ASSATITVTNT 989
            SG               + ++T   R        F G +   G + +  AS ++   T+T
Sbjct: 1200 SG-------------VSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDT 1246

Query: 990  AIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSS 1038
             ++  + TA+++   + T  ++  +T TT         +T  +GL+++S
Sbjct: 1247 TLSPGSTTASSLGPESTTFHSSPGSTETTLLP-----DNTTASGLLEAS 1290


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 180/787 (22%), Positives = 279/787 (35%), Gaps = 123/787 (15%)

Query: 329  SAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHS-WPTPLTSMHTAGH----SEQ 383
            S   + T  P  T  Q S  S  +D + +       T+S   TPLTS+  +      SE 
Sbjct: 1063 STTPADTSTPVTTYSQASSSSTTADGTSMPT----STYSEGSTPLTSVPVSTRLVVSSEA 1118

Query: 384  STFS-------IPGQESQHLTPGFTLQKWND-PTTRASTKSVSFKSM-LEDDLKLSSDED 434
            ST S       IP   S   +   T  +    PT+  S  +    SM +   L +SS+ +
Sbjct: 1119 STLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEAN 1178

Query: 435  DLE--PVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESES 492
             L   PV + T   T+TE       A+  + P + P     P  ++       +SSE+ +
Sbjct: 1179 TLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEAST 1238

Query: 493  SSESDSDTESS-TTDSESNEAPRVATPEPEPPSTNK------WQLDKWLNKVTSQNKSFI 545
             S S  DT +  TT +E++ +P  A     P ST          +      VTS   S +
Sbjct: 1239 LSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTL 1298

Query: 546  CGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIP 605
                 TP++T     P++   EV      ++S  PAE    P  S   E   P  +  + 
Sbjct: 1299 L---TTPVDTKG---PVVTSNEV------SSSPTPAEGTSMPT-STYSEGRTPLTSIPVN 1345

Query: 606  ETKALKHKLSTTSET-------VSQRTIGKKQPKKVE----KNTSTDEFTWPKPNITSST 654
             T      +S  S T       V+  T     P   E     N++  E T P  +I  ST
Sbjct: 1346 TTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVST 1405

Query: 655  PKEKES---------VELHDPPRGRNKATAHK------------PAPRKEPRPNIPLA-- 691
                 S         V+   P     +AT+              P+  K P  +IP++  
Sbjct: 1406 TPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNT 1465

Query: 692  PEKKKYRGPGKIVP-KSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEIC 750
            P            P  S   + T ++ S S T  E T  I +  P   S G+TA +    
Sbjct: 1466 PVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGT-SIAISTP---SEGSTALT---- 1517

Query: 751  GASLTLSTLMSSSGSNNNLSIS--------------NEEPTFSPIPVMQTEILS----PL 792
              S+ +ST   +S   N+LS +              +  PT +    MQT   S    PL
Sbjct: 1518 --SIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGSTPL 1575

Query: 793  RDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGK 852
                    L V  + + LS  P  S      +      T  +    T  T  E       
Sbjct: 1576 TSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEG------ 1629

Query: 853  RKHKPIEVAEKIPEKKQRLEEATTICLLP-----PCISPAPPHKPPNTRENNSSRRANRR 907
                P+  +  +        EA+T+   P     P I+       P   E  S   +   
Sbjct: 1630 ---SPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYT 1686

Query: 908  KEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKG 967
              E   P     +   P     +S  +     +     T     + P  +EG    +   
Sbjct: 1687 --EGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEG---TSMPN 1741

Query: 968  ISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTIT 1027
             + +EG TP  +   + T   ++ A+ T++AT I T+T   T+T   ++ TT    S  T
Sbjct: 1742 STPSEGTTPLTSIPVSTTPVLSSEAS-TLSATPIDTSTPVTTSTEATSSPTTAEGTSIPT 1800

Query: 1028 STITTGL 1034
            ST++ G+
Sbjct: 1801 STLSEGM 1807



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 209/1073 (19%), Positives = 353/1073 (32%), Gaps = 147/1073 (13%)

Query: 34   NQEVQQEDDLFSSGFDLFGEPYKVAEYTNKGDALANR-VQNTLGNYDEMKNLLTNHSNQN 92
            N  V    +  SS     G     + Y+ +G  + +  V  TL    E   L T   + N
Sbjct: 598  NTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSN 657

Query: 93   HLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIPPHQDNTHPSAPMPPPSVVILNSTLIHSN 152
                +  ++   + +   E +  P         + + + P   MP      +N+TL+ S+
Sbjct: 658  --TPVTTSTEATSSSTTAEGTSMPTST------YTEGSTPLTSMP------VNTTLVASS 703

Query: 153  RKSKPEWSRDSHNPSTVLASQASGQPN-----KMQTLTQDQSQAKLEDFFVYPAEQPQIG 207
              S    +    +     +++AS  P       M T T  +    L      P  +  + 
Sbjct: 704  EASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSM---PVSKTLLT 760

Query: 208  EVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESE-----FAVQAPGSPLVASSLLAPS 262
              E S  S    + P  +          S SP  +E      +  + GSPL+ S    P 
Sbjct: 761  SSEASTLS----TTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTS---IPV 813

Query: 263  SGLSVQNFPPGLYCKTSMGQQKP-TAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFG 321
            S   V +        T +    P T           A   S       E      ++   
Sbjct: 814  SITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVS 873

Query: 322  TLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWP----TPLTSMHT 377
            T L    + ++  T     +   T+     S P+  E     M  S P    TPLTSM  
Sbjct: 874  TTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGT--SMPTSTPGEGSTPLTSMPD 931

Query: 378  AG----HSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDE 433
            +      SE  T S    ++   TP  T  +     T A   S+   +  E    L+S  
Sbjct: 932  STTPVVSSEARTLSATPVDTS--TPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTP 989

Query: 434  DD-------------LEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQA 480
                             PV + T   T+TE       A+  + P + P     P   +  
Sbjct: 990  VSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPV 1049

Query: 481  SGGSGSSSESESSSESDSDTESS-TTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTS 539
            S    +SSE+ + S + +DT +  TT S+++ +   A     P ST   +    L  V  
Sbjct: 1050 STTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYS-EGSTPLTSVPV 1108

Query: 540  QNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPR 599
              +  +  +  T   T     P+   + V    + ++S   AE    P  S   E   P 
Sbjct: 1109 STRLVVSSEASTLSTT-----PVDTSIPVTTSTEASSSPTTAEGTSIPT-SPPSEGTTPL 1162

Query: 600  PTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKE 659
             +  +  T  +    S+ + T+S   +  K         S+   T    ++ +STP E+ 
Sbjct: 1163 ASMPVSTTLVV----SSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERS 1218

Query: 660  ----SVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDS 715
                S+ +   P   ++A+    +P     P                        + T +
Sbjct: 1219 TPLTSMPVRHTPVASSEASTLSTSPVDTSTP------------------------VTTSA 1254

Query: 716  STSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLS----TLMSSSGSNNNLSI 771
             TS S T  E T     LP    S G+T  +      +L  S    TL+++        +
Sbjct: 1255 ETSSSPTTAEGTS----LPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVV 1310

Query: 772  SNEEPTFSPIPVMQTEI--------LSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAP 823
            ++ E + SP P   T +         +PL        L     + +LS  P  +S     
Sbjct: 1311 TSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTT 1370

Query: 824  AKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEK-IPEKKQRLEEATTICLLPP 882
            +     E  + P      +       +G      I V+   +   +     AT +    P
Sbjct: 1371 ST----EACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTP 1426

Query: 883  CISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKN 942
              + A     P T E  S              P  +P     P +     N      + +
Sbjct: 1427 GTTSAEATSSPTTAEGISI-------------PTSTPSEGKTPLKSIPVSNTPVANSEAS 1473

Query: 943  IAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTN---TAIATATVTAT 999
               T  + S  P  T           +V+   TP + +S  I+  +   TA+ +  V+ T
Sbjct: 1474 TLSTTPVDSNSPVVTS---------TAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTT 1524

Query: 1000 AIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLS 1052
             + ++ + + +T  A T+T  TT S  +S+ TT    S      S  + PL S
Sbjct: 1525 TVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGSTPLTS 1577



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 186/940 (19%), Positives = 316/940 (33%), Gaps = 97/940 (10%)

Query: 128  DNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPN----KMQT 183
            + T P   +P    ++ NS +  S   + P    DS+ P T     +S  P      M T
Sbjct: 2276 EGTTPLTSIPVSHTLVANSEV--STLSTTPV---DSNTPFTTSTEASSPPPTAEGTSMPT 2330

Query: 184  LTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAK--EDSNPNSSGEDAFKEIFQSNSPEE 241
             T  +    L      P     +   E S  S    + S P ++   A      ++    
Sbjct: 2331 STSSEGNTPLTRM---PVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSM 2387

Query: 242  SEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKP-TAYVRPMDGQDQAPD 300
                     +PL +     P S + V +     +  T +    P T           A  
Sbjct: 2388 PTSTYSEGSTPLTS----VPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEG 2443

Query: 301  ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI 360
             S    P  E      ++   T       A +  T     +   T+     S P+  E+I
Sbjct: 2444 TSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDI 2503

Query: 361  LREMTHS--WPTPLTSMHTA----GHSEQSTFSI-------PGQESQHLTPGFTLQKWND 407
            +  ++ +    T LTS+  +       E ST S        P   S  ++   T  +   
Sbjct: 2504 VVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTS 2563

Query: 408  -PTTRASTKSVSFKSMLEDDLKLSSDEDDL---EPVKTLTTQCTATELYQAVEKAKPRNN 463
             PT+  S  S   +SM      L+S E       PV T     T+TE   +   AK  + 
Sbjct: 2564 MPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSM 2623

Query: 464  PVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESS-TTDSESNEAPRVATPEPEP 522
            P++ P        ++  S    +SSE+ + S +  DT +  TT + ++ +P  A     P
Sbjct: 2624 PISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMP 2683

Query: 523  PSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAE 582
             ST   +     N + S   + +     + + T     P+     V    + ++S   AE
Sbjct: 2684 TSTPGERSTPLTNILVST--TLLANSEASTLSTT----PVDTSTPVTTSAEASSSPTTAE 2737

Query: 583  PKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDE 642
                 + S   + + P  +  +        + ST S T    +I      +   + +T E
Sbjct: 2738 GTSMRI-STPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAE 2796

Query: 643  FTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGK 702
             T    +  S T     S+ ++  P   ++A      P     P                
Sbjct: 2797 VTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSS------ 2850

Query: 703  IVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSS 762
              P + E I    ST+   +    ++ +   P         + +       +T ST  SS
Sbjct: 2851 --PTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSS 2908

Query: 763  S---GSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSL 819
            S       ++ IS      +P+  +    + P+   E        +D    +R P  +S 
Sbjct: 2909 SPTTAEGTSMPISTPSEVSTPLTSILVSTV-PVAGSEASTLSTTPVD----TRTPVTTSA 2963

Query: 820  HAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICL 879
             A+ + P   E  + P      T  E+  P        + VA           EA+T+  
Sbjct: 2964 EAS-SSPTTAEGTSMP----ISTPGERRTPLTSMSVSTMPVASS---------EASTLSR 3009

Query: 880  LP-----PCISPAPPHKPPNTRENNSSRRANRRK-EEKLFPPPLSPLPEDPPRRRNVSGN 933
             P     P  +       P T E      +   +    L   P+S  P   P    +S  
Sbjct: 3010 TPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTT 3069

Query: 934  NGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISV-NEGDTPKKASSATITVTNTAIA 992
              P   +  +  + +++S+ P   EG    T   IS  +EG TP         +T   ++
Sbjct: 3070 --PVDSNSPVVTSTEVSSS-PTPAEG----TSMPISTYSEGSTP---------LTGVPVS 3113

Query: 993  TATVTATAIVTTTVTATATATATTTTTTTTISTITSTITT 1032
            T  VT++AI T + T   T+T  TT+T    S  TS  T+
Sbjct: 3114 TTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTS 3153



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 208/994 (20%), Positives = 351/994 (35%), Gaps = 149/994 (14%)

Query: 145  NSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQP 204
            N+ L  S   S P  + +  +  T   S+ S    +M   T   + ++       PA+  
Sbjct: 1011 NTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTS 1070

Query: 205  Q----IGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSL-- 258
                   +   S+ +A   S P S+  +    +  ++ P  +   V +  S L  + +  
Sbjct: 1071 TPVTTYSQASSSSTTADGTSMPTSTYSEGSTPL--TSVPVSTRLVVSSEASTLSTTPVDT 1128

Query: 259  LAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNL 318
              P +  +  +  P     TS+    P+    P+        +S TL  S E      N 
Sbjct: 1129 SIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMP----VSTTLVVSSE-----ANT 1179

Query: 319  SFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSM--- 375
               T +D K   A+S            +E S P   + V  +         TPLTSM   
Sbjct: 1180 LSTTPVDSKTQVATS------------TEASSPPPTAEVTSMPTSTPGERSTPLTSMPVR 1227

Query: 376  HT-AGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDED 434
            HT    SE ST S    ++   TP  T  + +   T A   S+   +  E    L+S   
Sbjct: 1228 HTPVASSEASTLSTSPVDTS--TPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTS--- 1282

Query: 435  DLEPVKTLTTQCTATELYQAVEKAKPRNNPV---NPPLATPQPPPAVQASGGSGSSSESE 491
                +   TT  T+ E    +        PV   N   ++P P          G+S  + 
Sbjct: 1283 ----IPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTP--------AEGTSMPTS 1330

Query: 492  SSSESDSDTES---STTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQ 548
            + SE  +   S   +TT   S+    ++T   +  +      +   +  TS+  S     
Sbjct: 1331 TYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSM---P 1387

Query: 549  NETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQ----KI 604
            N  P E  +  P    P+     V + AS + A P +         +A   PT      I
Sbjct: 1388 NSNPSEGTT--PLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISI 1445

Query: 605  PETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSS------TPKEK 658
            P +   + K    S  VS   +   +   +    ST       P +TS+      TP E 
Sbjct: 1446 PTSTPSEGKTPLKSIPVSNTPVANSEASTL----STTPVDSNSPVVTSTAVSSSPTPAEG 1501

Query: 659  ESVELHDPPRGRNKATAHKPAPRKEPRPNI-PLAPEKKKYRGPGKIVPKSREFIETDSST 717
             S+ +  P  G    T+   +        I  L+        P     ++     T   T
Sbjct: 1502 TSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGT 1561

Query: 718  S-DSNTDQEETLQIKVLPPC----IISGGNTAKSKEICGAS-LTLSTLMSSS----GSNN 767
            S  ++T  E +  +  LP      + S  NT  +  I   + +T ST  SSS    GS+ 
Sbjct: 1562 SMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSM 1621

Query: 768  NLSISNE-EPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKP 826
             +S  +E  P  + IPV  T + SP  +   L    V  +  +++     SS    PA+ 
Sbjct: 1622 TISTPSEGSPLLTSIPVSTTPVASP--EASTLSTTPVDSNSPVITSTEVSSS--PTPAEG 1677

Query: 827  DHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISP 886
                T+T  + +T +T++         +  P+  +         ++ +T      P  + 
Sbjct: 1678 TSMPTSTYTEGRTPLTSITV-------RTTPVASSAISTLSTTPVDNST------PVTTS 1724

Query: 887  APPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNG-PFGQDKNIAM 945
                  P T E  S    N    E   P    P+   P      S  +  P      +  
Sbjct: 1725 TEARSSPTTSEGTSM--PNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTT 1782

Query: 946  TGQITSTKPKRTEGKFCATFKGISVNEGDTP-------------KKASSATIT------- 985
            + + TS+ P   EG    T    +++EG TP              +AS+ + T       
Sbjct: 1783 STEATSS-PTTAEGTSIPTS---TLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSP 1838

Query: 986  -VTNTAIATATVTA--------------TAIVTTTVTATATATATTTTTTTTISTITSTI 1030
             VT+TA++++   A              TA+ +  V+ T  A++ T T +TT +  ++ +
Sbjct: 1839 VVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPV 1898

Query: 1031 TTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
            TT    SS       +++P   +S+    RP LT
Sbjct: 1899 TTYAQVSSSPTTADGSSMP---TSTPREGRPPLT 1929



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 181/948 (19%), Positives = 321/948 (33%), Gaps = 101/948 (10%)

Query: 129  NTHPSAPMPP-PSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQD 187
            N++PS    P  S+ +  + ++ S   +      D+  P T  A +A+  P   + ++  
Sbjct: 1388 NSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSA-EATSSPTTAEGIS-- 1444

Query: 188  QSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQ 247
                        P   P  G+    +         NS           SNSP  +  AV 
Sbjct: 1445 -----------IPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVS 1493

Query: 248  APGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKP 307
            +  +P       A  + +++     G    TS+     T     ++     P ++ T   
Sbjct: 1494 SSPTP-------AEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVT 1546

Query: 308  SIEFENSFGNLSFGTLLDGKPSAASSK--TKLPKFTILQTSEVSLPSDPSCVEEILREMT 365
            +    +S    + GT +     +  S   T LP  T+L  S  +     + ++      T
Sbjct: 1547 TYSQASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDS----KT 1602

Query: 366  HSWPTPLTSMHTAGHSEQSTFSIPGQESQHLT--PGFTLQKWNDPTTRASTKSVSFKSML 423
                +   S  T       T S P + S  LT  P  T    +   +  ST  V   S +
Sbjct: 1603 QVTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPV 1662

Query: 424  EDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGG 483
                ++SS     E     T+  T TE    +     R  PV     +      V  S  
Sbjct: 1663 ITSTEVSSSPTPAEGTSMPTS--TYTEGRTPLTSITVRTTPVASSAISTLSTTPVDNSTP 1720

Query: 484  SGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPP--STNKWQLDKW-LNKVTSQ 540
              +S+E+ SS  +   T    +       P  + P    P  S+    L    ++  T  
Sbjct: 1721 VTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPV 1780

Query: 541  NKSFICGQNETPMETISLP---------PPIIQPMEVQMKVKTNASQVPAEPKER--PLL 589
              S     + T  E  S+P         P    P+   +   + AS +   P +   P++
Sbjct: 1781 TTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVV 1840

Query: 590  SLIREKARPRPTQ--KIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKN---TSTDEFT 644
            +     + P P +   I  +   +   + TS  VS  T+   +   +      TST   T
Sbjct: 1841 TSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTT 1900

Query: 645  WPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPE---KKKYRGPG 701
            + + + +S T  +  S+    P  GR             P  +IP++       +     
Sbjct: 1901 YAQVS-SSPTTADGSSMPTSTPREGR------------PPLTSIPVSTTTVASSEINTLS 1947

Query: 702  KIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLS---- 757
              +  +R  + T S  S S T  + T     +P    S G+T  +      +L +S    
Sbjct: 1948 TTLADTRTPVTTYSQASSSPTTADGTS----MPTPAYSEGSTPLTSMPLSTTLVVSSEAS 2003

Query: 758  TLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHS 817
            TL ++    +  + ++ E + SP     T I +            + +   L+    G++
Sbjct: 2004 TLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNT 2063

Query: 818  SLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTI 877
             L   P     + T +     +A             +  P+  +  +        EA+T+
Sbjct: 2064 -LSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTL 2122

Query: 878  CLLP-----PCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSG 932
               P     P I+       P   E  S + +           PL+ +P        VS 
Sbjct: 2123 STTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRT----PLTSMP--------VST 2170

Query: 933  NNGPFGQDKNIAMTGQITSTK-PKRTEGKFC-ATFKGISV-----NEGDTPKKASSATIT 985
                      ++ T   TST     TE +    T +G S+     +EG TP  +   +  
Sbjct: 2171 TVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTM 2230

Query: 986  VTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTG 1033
               T+ A+ T++AT + T+T   T+T   ++ TT    S  TST++ G
Sbjct: 2231 PVVTSEAS-TLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEG 2277



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 184/920 (20%), Positives = 320/920 (34%), Gaps = 133/920 (14%)

Query: 212  SNPSAKEDS----NPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSV 267
            S+P+  ED     +  S G      I  S +P  S  A     +P+ ++S +  S+ +S 
Sbjct: 2495 SSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISS 2554

Query: 268  QNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGK 327
                      ++ G   PT+     +G      +  + KP    E S   LS   +    
Sbjct: 2555 S-------ATSAEGTSMPTSTYS--EGSTPLRSMPVSTKPLASSEAS--TLSTTPVDTSI 2603

Query: 328  PSAASSKTKLPKFTILQTS-EVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTF 386
            P   S++T     T   TS  +S PS          E++ S  + L S      SE ST 
Sbjct: 2604 PVTTSTETSSSPTTAKDTSMPISTPS----------EVSTSLTSILVSTMPVASSEASTL 2653

Query: 387  SIPGQESQHL--------TPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDL-- 436
            S    +++ L        +   T +  + PT+    +S    ++L     L++ E     
Sbjct: 2654 STTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLS 2713

Query: 437  -EPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSE 495
              PV T T   T+ E   +   A+  +  ++ P     P  ++  S    +SSE+ + S 
Sbjct: 2714 TTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVST 2773

Query: 496  SDSDTESS-TTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ--NKSFICGQNETP 552
            +  DT    TT +E++ +P  A     P ST      +    +TS   N + +       
Sbjct: 2774 TAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPS----ETSTPLTSMPVNHTPVASSEAGT 2829

Query: 553  METISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKH 612
            + T     P+     V    K ++S   AE    P+ S   E +    +  +  T     
Sbjct: 2830 LSTT----PVDTSTPVTTSTKASSSPTTAEGIVVPI-STASEGSTLLTSIPVSTTPVASS 2884

Query: 613  KLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNK 672
            + ST S T    +I      +   + +T E T    +  S       S+ +   P   ++
Sbjct: 2885 EASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSE 2944

Query: 673  ATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKV 732
            A+     P     P    A             P + E      ST         ++ +  
Sbjct: 2945 ASTLSTTPVDTRTPVTTSAEASSS--------PTTAEGTSMPISTPGERRTPLTSMSVST 2996

Query: 733  LPPCIISGGNTAKSKEICGASLTLSTLMSSS-----GSNNNLSISNEEPT-FSPIPVMQT 786
            +P         +++       +T ST  SSS     G+   +S  +E  T  + IPV  T
Sbjct: 2997 MPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTT 3056

Query: 787  EILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEK 846
             +  P  +   L    V  +  +++     SS    PA+      +T  +  T +T V  
Sbjct: 3057 PVAIP--EASTLSTTPVDSNSPVVTSTEVSSS--PTPAEGTSMPISTYSEGSTPLTGV-- 3110

Query: 847  PAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANR 906
                      P+            L   T +    P  +    H  P T E  S   +  
Sbjct: 3111 ----------PVSTTPVTSSAISTLS-TTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTP 3159

Query: 907  RKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTK-PKRTEGKFCATF 965
             +       PL+ +P        VS       +D  ++ T   TST     TE     T 
Sbjct: 3160 SEGST----PLTYMP--------VSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTA 3207

Query: 966  KGISV-----NEGDTP---------------------------------KKASSATITVT 987
            +G S+     +EG TP                                  +ASS+  T  
Sbjct: 3208 EGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAE 3267

Query: 988  NTAIATATVT--ATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSW 1045
             T++ T+T +  +T + +  V+ T  A++ T+T +TT +  ++ +TT    SS   +   
Sbjct: 3268 GTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADG 3327

Query: 1046 AALPLLSSSSTNVRRPKLTF 1065
             ++P  + S  +     ++F
Sbjct: 3328 TSMPTSTYSEGSTPLTNMSF 3347



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 148/738 (20%), Positives = 260/738 (35%), Gaps = 96/738 (13%)

Query: 370  TPLTSMHTAG----HSEQSTFSI-------PGQESQHLTPGFTLQKWNDPTTRASTKSVS 418
            TPLT M  +      SE ST S        P   S   T   T +  + PT+  S     
Sbjct: 3164 TPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTP 3223

Query: 419  FKSMLEDDLKLSSDEDDL---EPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPP 475
              S+   +  ++S E  +    PV + T   T+TE   +   A+  + P + P     P 
Sbjct: 3224 LTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPL 3283

Query: 476  PAVQASGGSGSSSESESSSESDSDTESS-TTDSESNEAPRVATPEPEPPSTNKWQLDKWL 534
             ++  S  + +SSE+ + S + +DT +  TT S+++ +P +A     P ST   +    L
Sbjct: 3284 TSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYS-EGSTPL 3342

Query: 535  NKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIRE 594
              ++      +  +  T   T     P+     V    + + S   AE    P  S   E
Sbjct: 3343 TNMSFSTTPVVSSEASTLSTT-----PVDTSTPVTTSTEASLSPTTAEGTSIP-TSSPSE 3396

Query: 595  KARPRPTQKIPETKALKHKLSTTSET-VSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSS 653
               P  +  +  T  +  +++T S T V   T+     +     T  +  + P  + TS 
Sbjct: 3397 GTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLP-TSTTSE 3455

Query: 654  TPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIET 713
                   + L   P   ++A+     P     P    +P            P + E    
Sbjct: 3456 GSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSS--------PTTAEVTSM 3507

Query: 714  DSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISN 773
             +ST+   +     + +   P                 AS   STL ++   +N    S+
Sbjct: 3508 PTSTAGEGSTPLTNMPVSTTPV----------------ASSEASTLSTTPVDSNTFVTSS 3551

Query: 774  EEPTFSP--IPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPD-HKE 830
             + + SP  + V    + +P     +L  +       LLS     SS  + P+ P   + 
Sbjct: 3552 SQASSSPATLQVTTMRMSTPSEGSSSLTTM-------LLSSTYVTSSEASTPSTPSVDRS 3604

Query: 831  TATKPKRQTAVT-----AVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLP---- 881
            T      Q+  T      +  P         P+ +   +      + EA T   LP    
Sbjct: 3605 TPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIM-PVSTTSVTISEAGTASTLPVDTS 3663

Query: 882  -PCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQD 940
             P I+       P T E  +       +       PL+ +P    R  +  G+       
Sbjct: 3664 TPVITSTQVSSSPVTPEGTTMPIWTPSEGS----TPLTTMPVSTTRVTSSEGST--LSTP 3717

Query: 941  KNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASS--ATITVTNTAIATATVTA 998
              +  T   TST+   +     +T   +S+     P + S+   TI V+ T +     ++
Sbjct: 3718 SVVTSTPVTTSTEAISSSATLDSTTMSVSM-----PMEISTLGTTILVSTTPVTRFPESS 3772

Query: 999  TAIVTTTVTATATATA------------TTTTTTTTISTITSTITTGLMDSSHLEMTSWA 1046
            T  + +  T+ +  TA            TTT   +T S  ++ +TT L+  S + + S +
Sbjct: 3773 TPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLI--SPISVMSPS 3830

Query: 1047 ALPLLSSSSTNVRRPKLT 1064
                LS+   +   P LT
Sbjct: 3831 EASTLSTPPGDTSTPLLT 3848



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 193/967 (19%), Positives = 323/967 (33%), Gaps = 106/967 (10%)

Query: 133  SAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNK-------MQTLT 185
            + P+      IL++T + SN          S  P+    S  +  P++       M   T
Sbjct: 3231 NTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVST 3290

Query: 186  QDQSQAKLEDFFVYPAEQPQ----IGEVEESNPSAKEDSNPNSS---GEDAFKEIFQSNS 238
               + ++       PA+         +   S P A   S P S+   G      +  S +
Sbjct: 3291 TTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTT 3350

Query: 239  PEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQA 298
            P  S  A     +P+  S+ +  S+  S+          T+ G   PT+   P +G    
Sbjct: 3351 PVVSSEASTLSTTPVDTSTPVTTSTEASLSP-------TTAEGTSIPTS--SPSEGTTPL 3401

Query: 299  PDISPTLKPSIEFE-NSFGN--LSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPS 355
              +  +  P +  E N+     +   TL+     A+SS T + + T L TS  S  S P 
Sbjct: 3402 ASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPT-IAEGTSLPTSTTSEGSTPL 3460

Query: 356  CVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTK 415
             +  +         TP+ S      SE ST S    ++   TP  T    N   T A   
Sbjct: 3461 SIMPLST-------TPVAS------SEASTLSTTPVDTS--TPVTTSSPTNSSPTTAEVT 3505

Query: 416  SVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPP 475
            S+   +  E    L++      PV +      +T    +       +   + P AT Q  
Sbjct: 3506 SMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSP-ATLQVT 3564

Query: 476  PAVQASGGSGSSS------------ESESSSESDSDTESST---TDSESNEAP---RVAT 517
                ++   GSSS             SE+S+ S    + ST   T ++SN  P    V T
Sbjct: 3565 TMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVIT 3624

Query: 518  PEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNAS 577
                 PS     L       TS   S     +  P++T +   P+I   +V      ++S
Sbjct: 3625 LPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTST---PVITSTQV------SSS 3675

Query: 578  QVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKN 637
             V  E    P+ +   E + P  T  +  T+      S+   T+S  ++    P      
Sbjct: 3676 PVTPEGTTMPIWTP-SEGSTPLTTMPVSTTRVT----SSEGSTLSTPSVVTSTPVTTSTE 3730

Query: 638  TSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPR--KEPRPNIPLAPEKK 695
              +   T     ++ S P E  ++       G     +  P  R  +   P+IP      
Sbjct: 3731 AISSSATLDSTTMSVSMPMEISTL-------GTTILVSTTPVTRFPESSTPSIPSVYTSM 3783

Query: 696  KYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLT 755
                  +    S   +E  ++   S T +  TL   VL    IS  +     E       
Sbjct: 3784 SMTTASE-GSSSPTTLEGTTTMPMSTTSERSTLLTTVL----ISPISVMSPSEA------ 3832

Query: 756  LSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPG 815
             STL +  G  +   +++ +     IP   T I   +    +     + +   L +  PG
Sbjct: 3833 -STLSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLPTSFPG 3891

Query: 816  HSSLHAAPAKPD-----HKETATKPKRQTAVTAVEKPAPKGKRKHKPIEV-AEKIPEKKQ 869
             S     P           +TA+ P    A T       +G      I + +  +     
Sbjct: 3892 ASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGSTPGTTIFIPSTPVTSSTA 3951

Query: 870  RLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRN 929
             +  ATT  +  P I+        NT   +SS         K F  P             
Sbjct: 3952 DVFPATTGAVSTPVITSTEL----NTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTM 4007

Query: 930  VSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNT 989
             +  + P    +    +    S            T      +E   P   +S TI  T  
Sbjct: 4008 STAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTITSHTIPPTFP 4067

Query: 990  AIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALP 1049
               ++T   T+  +TTV   A  T TT T  +T +T   T+TT  + ++    ++  + P
Sbjct: 4068 PAHSSTPPTTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTP 4127

Query: 1050 LLSSSST 1056
             +  ++T
Sbjct: 4128 TVPRTTT 4134



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 158/796 (19%), Positives = 275/796 (34%), Gaps = 139/796 (17%)

Query: 317  NLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEE--ILREMTHSWPTPLTS 374
            N+   T+L     A+++ T         T+     S P+  E+  I         TPLTS
Sbjct: 397  NMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTS 456

Query: 375  MHTA----GHSEQSTFSI-PGQESQHLTPGF-------TLQKWNDPTTRASTKSVSFKSM 422
            M  +      SE S  S  P      +T          T +  + PT+  S  S    SM
Sbjct: 457  MPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSM 516

Query: 423  LEDDLKLSSDEDDL---EPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQ 479
                + ++S E       PV T T   T++E   +    +  + P + P     P   + 
Sbjct: 517  SVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMP 576

Query: 480  ASGGSGSSSESESSSESDSDTESS-TTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVT 538
             S     SSE+ ++S + +D+ +  TT SE++ +   A     P ST      +    +T
Sbjct: 577  VSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTST----YSERGTTIT 632

Query: 539  SQNKS--FICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKA 596
            S + S   +     + + T     P+     V    +  +S   AE    P  S   E +
Sbjct: 633  SMSVSTTLVASSEASTLSTT----PVDSNTPVTTSTEATSSSTTAEGTSMPT-STYTEGS 687

Query: 597  RPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPK 656
             P  +  +  T     + ST S T     +    P       S+   T    ++ +STP 
Sbjct: 688  TPLTSMPVNTTLVASSEASTLSTT----PVDTSTPVTTSTEASSSPTTADGASMPTSTPS 743

Query: 657  EKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSS 716
            E  +                                       P   +P S+  + +  +
Sbjct: 744  EGST---------------------------------------PLTSMPVSKTLLTSSEA 764

Query: 717  TSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEP 776
            ++ S T  + +  I            T  ++  C  + T  T M  S      + S   P
Sbjct: 765  STLSTTPLDTSTHI------------TTSTEASCSPTTTEGTSMPIS------TPSEGSP 806

Query: 777  TFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPK 836
              + IPV  T + SP  +   L    V  +  + +     SS    PA+     T+T  +
Sbjct: 807  LLTSIPVSITPVTSP--EASTLSTTPVDSNSPVTTSTEVSSS--PTPAEGTSMPTSTYSE 862

Query: 837  RQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTR 896
             +T +T++            P+            L   T +    P  +       P T 
Sbjct: 863  GRTPLTSM------------PVSTTLVATSAISTLS-TTPVDTSTPVTNSTEARSSPTTS 909

Query: 897  ENNSSRRANRRK-EEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPK 955
            E  S   +   +    L   P S  P      R +S    P      +  + + TS+ P 
Sbjct: 910  EGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSAT--PVDTSTPVTTSTEATSS-PT 966

Query: 956  RTEGKFCATFKGISVNEGDTP-----------KKASSATITVT----NTAIATATVTA-- 998
              EG    T    + +EG TP             + ++T++ T    NT + T+T  +  
Sbjct: 967  TAEGTSIPTS---TPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSP 1023

Query: 999  ------TAIVTTTVTATAT-ATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLL 1051
                  T++ T+T +  +T  T    +TT   S+ TST++T   D+S   +T+++     
Sbjct: 1024 PPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTS-TPVTTYSQASSS 1082

Query: 1052 SSSSTNVRRPKLTFDD 1067
            S+++     P  T+ +
Sbjct: 1083 STTADGTSMPTSTYSE 1098



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 163/835 (19%), Positives = 289/835 (34%), Gaps = 137/835 (16%)

Query: 329  SAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMH----TAGHSEQS 384
            S   + T  P  T  Q S     +D S +             PLTS+     T   SE +
Sbjct: 1888 STTPAVTSTPVTTYAQVSSSPTTADGSSMPT---STPREGRPPLTSIPVSTTTVASSEIN 1944

Query: 385  TFSIPGQESQHLTPGFTL-QKWNDPTTRASTK---------SVSFKSM-LEDDLKLSSDE 433
            T S    +++  TP  T  Q  + PTT   T          S    SM L   L +SS+ 
Sbjct: 1945 TLSTTLADTR--TPVTTYSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEA 2002

Query: 434  DDLE--PVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPA--------VQASGG 483
              L   PV T T   T+TE   +   A   +   + P     P           V + G 
Sbjct: 2003 STLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGN 2062

Query: 484  SGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKS 543
            + S++  +S ++  + TE+S++ +    +  ++ P    P      L      V S   S
Sbjct: 2063 TLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLST--TPVASPEAS 2120

Query: 544  FICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQK 603
             +   + TP+++ S   P+I   EV      ++S +P E       S   ++  P  +  
Sbjct: 2121 TL---STTPVDSNS---PVITSTEV------SSSPIPTEGTSMQT-STYSDRRTPLTSMP 2167

Query: 604  IPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES--- 660
            +  T      +ST S T    +       +   + +T E T    ++ +STP E  +   
Sbjct: 2168 VSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGT----SMPTSTPSEGSTPFT 2223

Query: 661  ---------------------VELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRG 699
                                 V+   P     +AT+   +P      +IP +   +    
Sbjct: 2224 SMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATS---SPTTAEGTSIPTSTLSEGTT- 2279

Query: 700  PGKIVPKSREFI---------------ETDSSTSDSNTDQEETLQIKVLPPCIISGGNTA 744
            P   +P S   +                T  +TS   +    T +   +P    S GNT 
Sbjct: 2280 PLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTP 2339

Query: 745  KSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPI---------PVMQTEILSPLRDH 795
             ++      + +ST M +S   + LS +  + T +P+         P    +   P   +
Sbjct: 2340 LTR------MPVSTTMVASFETSTLSTTPAD-TSTPVTTYSQAGSSPTTADDTSMPTSTY 2392

Query: 796  ENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVE------KPAP 849
                     + +  +  V   +S H+           T  +  ++ T  E       P  
Sbjct: 2393 SEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPS 2452

Query: 850  KGKRK--HKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRR 907
            +G       P+     +  +   L   T +    P  +       P T E+     +   
Sbjct: 2453 EGTTPLASMPVSTTPVVSSEAGTLS-TTPVDTSTPMTTSTEASSSPTTAEDIVVPISTAS 2511

Query: 908  KEEKLFPP-PLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFK 966
            +   L    P+S  P   P    +S    P   +  +  + +I+S+     EG    T  
Sbjct: 2512 EGSTLLTSIPVSTTPVASPEASTLSTT--PVDSNSPVVTSTEISSSATS-AEGTSMPTS- 2567

Query: 967  GISVNEGDTPKK---------ASSATITVTNTAIATATVTATAIVTTTVTATATATATTT 1017
              + +EG TP +         ASS   T++ T + T+    T+  T++   TA  T+   
Sbjct: 2568 --TYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPI 2625

Query: 1018 TTTTTISTITSTITTGLMDSSHLEMTSWAALPL----LSSSSTNVRRPKLTFDDS 1068
            +T + +ST  ++I    M  +  E ++ +  P+    L ++ST       T + S
Sbjct: 2626 STPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGS 2680



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 124/684 (18%), Positives = 236/684 (34%), Gaps = 68/684 (9%)

Query: 397  TPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVE 456
            TPG +  +     +R +++S             +SD   L P  T  T    T     V 
Sbjct: 102  TPGVSSTRMTPTESRTTSES-------------TSDSTTLFPSSTEDTSSPTTPEGTDVP 148

Query: 457  KAKPRNNPVNPPLA--TPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPR 514
             + P    ++  +A  +  P P+ +A        +  +   + +   SS T  ES   P+
Sbjct: 149  MSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPK 208

Query: 515  VATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT 574
                E   P T+   +     KV S              E I+L   +  P+E+   V T
Sbjct: 209  STNSEGSTPLTS---MPASTMKVASS-------------EAITL---LTTPVEISTPV-T 248

Query: 575  NASQVPAEPK--ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPK 632
             ++Q  + P   E P LS         P  ++P +  L   +S+ + T+S        P 
Sbjct: 249  ISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLV--VSSEASTLSTTPAATNIPV 306

Query: 633  KVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAP 692
                  S+   T    +I +ST  E  +     P      AT+        P     L  
Sbjct: 307  ITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVT 366

Query: 693  EKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGA 752
               +   P  + P + E     +ST    +     + +  +   +++    + +  I   
Sbjct: 367  TSTE---PSSL-PTTAEATSMLTSTLSEGSTPLTNMPVSTI---LVASSEASTTSTIPVD 419

Query: 753  SLTLSTLMSSSGSN----NNLSISNEEPTFSPIPVMQTEI-LSPLRDHENLKNLWVKIDL 807
            S T  T  S + S+     + SI+   P+    P+    +  +P+   E        +D 
Sbjct: 420  SKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDS 479

Query: 808  DLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVE------KPAPKGKRKHKPIEVA 861
                     +S     A+ +   T+T  +  T +T++         +        P++ +
Sbjct: 480  KTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTS 539

Query: 862  EKIPEKKQRLEEATT-----ICLLPPCISPAP-PHKPPNTR---ENNSSRRANRRKEEKL 912
              +    +    +TT     I    P     P  + P +TR    + +S  +    +   
Sbjct: 540  TPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNT 599

Query: 913  FPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNE 972
            F    S            S     + +      +  +++T    +E    +T    S   
Sbjct: 600  FVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTP 659

Query: 973  GDTPKKASSATITVTNTAIATATVT--ATAIVTTTVTATATATATTTTTTTTISTITSTI 1030
              T  +A+S++ T   T++ T+T T  +T + +  V  T  A++  +T +TT    ++ +
Sbjct: 660  VTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPV 719

Query: 1031 TTGLMDSSHLEMTSWAALPLLSSS 1054
            TT    SS       A++P  + S
Sbjct: 720  TTSTEASSSPTTADGASMPTSTPS 743



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 208/1007 (20%), Positives = 347/1007 (34%), Gaps = 147/1007 (14%)

Query: 128  DNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQD 187
            + + P   MP  ++++++S    S   + P  +      ST   S  + +   + T T  
Sbjct: 3161 EGSTPLTYMPVSTMLVVSSE--DSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPS 3218

Query: 188  QSQAKLEDFFVYPAEQPQIGEVEESNPSAKE-DSN-PNSSGEDAFKEIFQSNSPEESEFA 245
            +    L      P     +   E S  S    DSN P ++  +A      S+SP  +E  
Sbjct: 3219 EGMTPLTSV---PVSNTPVASSEASILSTTPVDSNTPLTTSTEA------SSSPPTAEGT 3269

Query: 246  VQAPGSPLVASSLLA--PSSGLSVQNFPPGLYCKTSMGQQKP-TAYVRPMDGQDQAPDIS 302
                 +P   S+ L   P S  +V +        T      P T Y +       A   S
Sbjct: 3270 SMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTS 3329

Query: 303  PTLKPSIEFENSFGNLSFGT--LLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI 360
                   E      N+SF T  ++  + S  S+        +  ++E SL    +    I
Sbjct: 3330 MPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSI 3389

Query: 361  LREMTHSWPTPLTSMHTAG----HSEQSTFSIPGQESQHLTPGFTLQKWNDPT----TRA 412
                     TPL SM  +      SE +T S    +S  L    T +  + PT    T  
Sbjct: 3390 PTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTST-EASSSPTIAEGTSL 3448

Query: 413  STKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATP 472
             T + S  S     + LS+         TL+T  T  +    V  + P N+       T 
Sbjct: 3449 PTSTTSEGSTPLSIMPLSTTPVASSEASTLST--TPVDTSTPVTTSSPTNSSPTTAEVTS 3506

Query: 473  QPPPAVQASGGSGSS------------SESESSSESDSDTESSTTDSESNEAP------R 514
             P     ++ G GS+            + SE+S+ S +  +S+T  + S++A       +
Sbjct: 3507 MPT----STAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQ 3562

Query: 515  VATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKT 574
            V T     PS     L   L   T    S    +  TP       P + +   V    ++
Sbjct: 3563 VTTMRMSTPSEGSSSLTTMLLSSTYVTSS----EASTPST-----PSVDRSTPVTTSTQS 3613

Query: 575  NASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKV 634
            N++  P E     +++L      P  T     T      +STTS T+S+       P   
Sbjct: 3614 NSTPTPPE-----VITL------PMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPV-- 3660

Query: 635  EKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEK 694
              +TST   T  + + +  TP E  ++ +  P  G    T    +  +        + E 
Sbjct: 3661 --DTSTPVITSTQVSSSPVTP-EGTTMPIWTPSEGSTPLTTMPVSTTRVT------SSEG 3711

Query: 695  KKYRGPGKI----VPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGG--------N 742
                 P  +    V  S E I + ++   +       ++I  L   I+           +
Sbjct: 3712 STLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGTTILVSTTPVTRFPES 3771

Query: 743  TAKSKEICGASLTLSTLMSSSGSNNNLSISNEEP---TFSPIPVMQTEILSPLRDHENLK 799
            +  S      S++++T    S S   L  +   P   T     ++ T ++SP+       
Sbjct: 3772 STPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPI------- 3824

Query: 800  NLWVKIDLDLLSRVPGHSSL----------HAAPAKPDHKETATKPKRQTAVTA--VEKP 847
            ++    +   LS  PG +S            + PA+      +   +R T +T   V   
Sbjct: 3825 SVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTT 3884

Query: 848  APKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRR 907
             P          +A   P     L+ +TT    P   + + P  P  T  + S       
Sbjct: 3885 LPTS---FPGASIASTPP-----LDTSTTFT--PSTDTASTPTIPVATTISVSVITEGST 3934

Query: 908  KEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKG 967
                +F      +P  P      S     F        T  ITST+         +T   
Sbjct: 3935 PGTTIF------IPSTPV----TSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTS 3984

Query: 968  ISVN-EGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATT-TTTTTTIST 1025
             S   E  TP   ++A +T    + A +T   T+   TT  +T +AT+T  T+T+ T   
Sbjct: 3985 FSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRP 4044

Query: 1026 IT--------STITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
            +T        STIT+  +  +     S +  P  S+SST V    +T
Sbjct: 4045 VTPSSESSRPSTITSHTIPPTFPPAHS-STPPTTSASSTTVNPEAVT 4090



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 79/350 (22%), Positives = 129/350 (36%), Gaps = 48/350 (13%)

Query: 735  PCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILS---- 790
            P + S   T         S + ST +  S + +  S +  E T  P+     E +S    
Sbjct: 103  PGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMA 162

Query: 791  -----PLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVE 845
                 PL   E   +L  K+D+      P  +S  A+ + P   E+ T PK     T  E
Sbjct: 163  FVSTAPLPSFEAYTSLTYKVDMS----TPLTTSTQAS-SSPTTPESTTIPKS----TNSE 213

Query: 846  KPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLP-----PCISPAPPHKPPNTRENNS 900
               P        ++VA           EA T+   P     P    A     P T E  S
Sbjct: 214  GSTPLTSMPASTMKVASS---------EAITLLTTPVEISTPVTISAQASSSPTTAEGPS 264

Query: 901  -SRRANRRKEEKLFPPPLSPL----PEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPK 955
             S  A       L   PLS +     E        +  N P        +T    S+ P 
Sbjct: 265  LSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIP-------VITSTEASSSPT 317

Query: 956  RTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATAT 1015
              EG    T    +  EG TP  ++ A+     T+   +T++ T + T+T+  T+T  ++
Sbjct: 318  TAEGTSIPTS---TYTEGSTPLTSTPASTMPVATS-EMSTLSITPVDTSTLVTTSTEPSS 373

Query: 1016 TTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTF 1065
              TT    S +TST++ G    +++ +++       +S+++ +     TF
Sbjct: 374  LPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTF 423



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 144/789 (18%), Positives = 271/789 (34%), Gaps = 70/789 (8%)

Query: 321  GTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGH 380
            G+  +      S+    P+  +  ++   + S  S V      ++ +  TP  S  T+  
Sbjct: 62   GSAANTATGTTSTNVVEPRMYLSCSTNPEMTSIESSVTSDTPGVSSTRMTPTESRTTSES 121

Query: 381  SEQSTFSIPGQE---SQHLTPGFTLQKWNDPTTRASTKSVSFKSM-----LEDDLKLSSD 432
            +  ST   P      S   TP  T    + P+  + + +++F S       E    L+  
Sbjct: 122  TSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYK 181

Query: 433  EDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESES 492
             D   P+ T T   ++    ++    K  N+  + PL T  P   ++ +     +  +  
Sbjct: 182  VDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPL-TSMPASTMKVASSEAITLLTTP 240

Query: 493  SSESDSDTESSTTDSESN--EAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFI----- 545
               S   T S+   S     E P ++   P   ST   ++   +  V S   S +     
Sbjct: 241  VEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPA 300

Query: 546  -----------CGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIRE 594
                          + T  E  S+P          +   T AS +P    E   LS+   
Sbjct: 301  ATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPL-TSTPASTMPVATSEMSTLSIT-- 357

Query: 595  KARPRPTQKIPETKALKHKLSTTSETVSQ--RTIGKKQPKKVEKNTSTDEFTWPKPNITS 652
               P  T  +  T      L TT+E  S    T+ +          ST      + + TS
Sbjct: 358  ---PVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTS 414

Query: 653  STPKEKESVELHDPPRGRNKATAHK-------PAPRKEPRPNIPLA--PEKKKYRGPGKI 703
            + P + ++          +  TA         P+    P  ++P++  P           
Sbjct: 415  TIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLST 474

Query: 704  VPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG----ASLTLSTL 759
             P   +   T  +TS   +    T ++  +P    S G+T  +         AS   STL
Sbjct: 475  TPVDSK---TQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTL 531

Query: 760  MSSSGSNNNLSISNEEPTFSPIPVMQTEI--LSPLRDHENLKNLWVKIDLDLLSRVPGHS 817
             ++    +    ++ E + S      T I   +P      L N+ V   L + S     S
Sbjct: 532  STTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEA---S 588

Query: 818  SLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAE-KIPEKKQRLEEATT 876
            +    PA  +   T +     ++ TA     P      +   +    +        EA+T
Sbjct: 589  TTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEAST 648

Query: 877  ICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGP 936
            +   P  +    P        ++S+           +    +PL   P     V+ +   
Sbjct: 649  LSTTP--VDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEAS 706

Query: 937  FGQDKNIAMTGQIT-----STKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAI 991
                  +  +  +T     S+ P   +G   A+    + +EG TP  +   + T+  ++ 
Sbjct: 707  TLSTTPVDTSTPVTTSTEASSSPTTADG---ASMPTSTPSEGSTPLTSMPVSKTLLTSSE 763

Query: 992  ATATVTATAIVTTT--VTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALP 1049
            A+ T++ T + T+T   T+T  + + TTT  T++   T +  + L+ S  + +T   +  
Sbjct: 764  AS-TLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPE 822

Query: 1050 LLSSSSTNV 1058
              + S+T V
Sbjct: 823  ASTLSTTPV 831



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 196/991 (19%), Positives = 324/991 (32%), Gaps = 158/991 (15%)

Query: 125  PHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQA-SGQPNKMQT 183
            P  + T P A MP  + ++++S    +   + P  S+     ST  +S   + +   M T
Sbjct: 1154 PPSEGTTPLASMPVSTTLVVSSEA--NTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPT 1211

Query: 184  LTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESE 243
             T  +    L               V  +  ++ E S  ++S  D    +  + S E S 
Sbjct: 1212 STPGERSTPLTSM-----------PVRHTPVASSEASTLSTSPVDTSTPV--TTSAETSS 1258

Query: 244  FAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQ-----DQA 298
                A G+ L  S+    S+ L+  + P      TS   +  T    P+D +        
Sbjct: 1259 SPTTAEGTSLPTSTTSEGSTLLT--SIPVSTTLVTS--PEASTLLTTPVDTKGPVVTSNE 1314

Query: 299  PDISPTLKPSIEFENSF---GNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPS 355
               SPT         S    G     ++       ASS   +   T +  S     S  +
Sbjct: 1315 VSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEA 1374

Query: 356  CVEEILRE---MTHSWP----TPLTSMHTAG----HSEQSTFSIPGQESQHLTPGFTLQK 404
            C      E   M +S P    TPLTS+  +      SE ST S    ++   TPG T  +
Sbjct: 1375 CSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTS--TPGTTSAE 1432

Query: 405  WNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNP 464
                 T A   S+   +  E    L S      PV        +T    +       N+P
Sbjct: 1433 ATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDS-------NSP 1485

Query: 465  VNPPLA-TPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPP 523
            V    A +  P PA   S    + SE  ++  S   + ++   SE N           P 
Sbjct: 1486 VVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPV 1545

Query: 524  STNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEP 583
            +T             +  ++    +  TP+ ++        P+   + V + A+ +   P
Sbjct: 1546 TTYSQASSSPTTADGTSMQTSTYSEGSTPLTSL--------PVSTMLVVSSEANTLSTTP 1597

Query: 584  KERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQR--TIGKKQPKKVEKNTSTD 641
             +                 K   T + +   STT+E  S    T  +  P       ST 
Sbjct: 1598 ID----------------SKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTT 1641

Query: 642  EFTWPKPNITSSTPKEKESVELHD--------PPRGRNKATAHKPAPRKEPRPNIPLAPE 693
                P+ +  S+TP +  S  +          P  G +  T+     R  P  +I +   
Sbjct: 1642 PVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGRT-PLTSITV--- 1697

Query: 694  KKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGA- 752
                    +  P +   I T S+T   N+    T       P    G +   S    G  
Sbjct: 1698 --------RTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTT 1749

Query: 753  ---SLTLSTLMSSSGSNNNLSIS----------NEEPTFSPIPVMQTEI--------LSP 791
               S+ +ST    S   + LS +          + E T SP     T I        ++P
Sbjct: 1750 PLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTP 1809

Query: 792  LRDHENLKNLWVKIDLDLLSRVPGHS----------SLHAAPAKPDHKETATKPKRQTAV 841
            L        L    +   LS  P  S          S    PA+     T+T  +  TA+
Sbjct: 1810 LTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTPSEGSTAL 1869

Query: 842  TAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSS 901
            T++            P+        +   L   T      P  + A     P T + +S 
Sbjct: 1870 TSI------------PVSTTTVASSETNTLS-TTPAVTSTPVTTYAQVSSSPTTADGSSM 1916

Query: 902  RRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN--NGPFGQDKNIAMTGQITSTKPKRTEG 959
              +  R+      PPL+ +P       +   N  +      +    T    S+ P   +G
Sbjct: 1917 PTSTPREGR----PPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADG 1972

Query: 960  KFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTT 1019
                T    + +EG TP         +T+  ++T  V ++   T + T   T+T  TT+T
Sbjct: 1973 TSMPT---PAYSEGSTP---------LTSMPLSTTLVVSSEASTLSTTPVDTSTPATTST 2020

Query: 1020 TTTISTITSTITTGLMDSSHLEMTSWAALPL 1050
              + S  T+  T+    +     T  A +P+
Sbjct: 2021 EGSSSPTTAGGTSIQTSTPSERTTPLAGMPV 2051



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 82/411 (19%), Positives = 147/411 (35%), Gaps = 36/411 (8%)

Query: 739  SGGNTAKSKEICGASLTLS----TLMSSSGSNNNLSISNEEPTFSP-------IPVMQ-T 786
            SGG+T  ++      L +S    TL ++  + N   I++ E + SP       IP    T
Sbjct: 271  SGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYT 330

Query: 787  EILSPLRDHENLKNLWVKIDLDLLSRVP-GHSSLHAAPAKPDHKETATKPKRQTAVTAVE 845
            E  +PL             ++  LS  P   S+L     +P    T  +       T  E
Sbjct: 331  EGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSE 390

Query: 846  KPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPP-----CISPAPPHKPPNTRENNS 900
               P        I VA           EA+T   +P        + +     P T E+ S
Sbjct: 391  GSTPLTNMPVSTILVASS---------EASTTSTIPVDSKTFVTTASEASSSPTTAEDTS 441

Query: 901  SRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGK 960
               A     E   P    P+   P      S  +      K    T    S+ P   E  
Sbjct: 442  I--ATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVN 499

Query: 961  FCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTT 1020
               T    + +EG TP  + S + T+   +   +T++ T + T+T   T++  ++++TT 
Sbjct: 500  SMPTS---TPSEGSTPLTSMSVS-TMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTP 555

Query: 1021 TTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAK 1080
               S  TST + G    +++ +++   +   +S+++       TF  +   A      A+
Sbjct: 556  EGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAE 615

Query: 1081 KLKHKADALFEKFGKAVNYADAALSFTECGNA--MERDPLEAKSPYTMYSE 1129
                      E+ G  +     + +      A  +   P+++ +P T  +E
Sbjct: 616  GTSMPTSTYSER-GTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTE 665



 Score = 34.3 bits (77), Expect = 0.81
 Identities = 25/113 (22%), Positives = 52/113 (46%), Gaps = 14/113 (12%)

Query: 970  VNEGDTPKKASSATITVTNTAIATAT-----VTATAIVTTTVTAT-----ATATATTTTT 1019
            + EG TP      TI + +T + ++T      T  A+ T  +T+T     +T++++TTT+
Sbjct: 3929 ITEGSTP----GTTIFIPSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTS 3984

Query: 1020 TTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNA 1072
             +T    T+   T     +++ M++  + P  +S         L+   + H +
Sbjct: 3985 FSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTS 4037


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 106/487 (21%), Positives = 181/487 (37%), Gaps = 47/487 (9%)

Query: 236  SNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQ 295
            S   +ES  A   P  P   +    P +  S ++  P       +   KPT      DG 
Sbjct: 1027 SRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGS 1086

Query: 296  DQAPD--ISPTL-----KPSIEFENSFGNLSF---GTLLDGKPSAASSKTKLPKFTILQT 345
             +AP+  +S  L     KP I    S     F       +  PS ++++   PK T   T
Sbjct: 1087 QEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQAT 1146

Query: 346  SEVSLPSDPSCVEEILREMTHSWPT-----PLTSMHTA----GHSEQSTFSIPGQ---ES 393
               +  S     E ++       P+     P+TS  T+    G   +S+   P      +
Sbjct: 1147 RSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTA 1206

Query: 394  QHLTPGFTLQK--WNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATEL 451
              L P  +  +   ++PT++A T+    +S ++    +     +L+P  +     T+   
Sbjct: 1207 LELQPSTSTDRPVTSEPTSQA-TRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPT 1265

Query: 452  YQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNE 511
            YQA    K R++     + TP+P           +S++   + +  S T  S T+  S  
Sbjct: 1266 YQATRGRKNRSS-----VKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSS-- 1318

Query: 512  APRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMK 571
               V TPE   P+  + Q+    ++  +   +    ++ T M ++  P   + P+  ++ 
Sbjct: 1319 ---VKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTV-PIAPELP 1374

Query: 572  VKTNASQ-VPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLST----TSETVSQRTI 626
              T+  Q V  EP  R         +   P   +P    L+   ST    T E  SQ T 
Sbjct: 1375 PSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATR 1434

Query: 627  GKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRP 686
            G+     V K   T   T P+   ++ST +           RGR   ++      K P  
Sbjct: 1435 GRTNRSSV-KTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSS-----VKTPET 1488

Query: 687  NIPLAPE 693
             +P APE
Sbjct: 1489 VVPTAPE 1495



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 127/608 (20%), Positives = 215/608 (35%), Gaps = 68/608 (11%)

Query: 456  EKAKPRNNPVN---------PPLATPQPP---PAVQASGGSGSSSESESSSESDSDTESS 503
            E   P   P+N         PPL +P  P   P V+ +   GS    E+   S+ +    
Sbjct: 1044 EAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHP 1103

Query: 504  TTDSESNEAPRV-------ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETI 556
                 + ++ R+       A PEP P ++    +     K TSQ       ++ T   ++
Sbjct: 1104 KPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTP---KPTSQ-----ATRSRTNRSSV 1155

Query: 557  SLPPPIIQPMEVQMKVKTNASQ-VPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLS 615
              P P++ P   +++  T+  Q V +EP  +         +   P   +P    L+   S
Sbjct: 1156 KTPEPVV-PTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTS 1214

Query: 616  T----TSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRN 671
            T    TSE  SQ T G+K    V K       T P+   ++ST +   S   +   RGR 
Sbjct: 1215 TDRPVTSEPTSQATRGRKNRSSV-KTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRK 1273

Query: 672  KATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIK 731
              ++ K      P P +P APE +      + V        T S T+ S+    ET+ + 
Sbjct: 1274 NRSSVKT-----PEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETV-VP 1327

Query: 732  VLPPCIISGG--NTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEP--TFSPIPVMQTE 787
              P   IS         K     + + + + S     + + I+ E P  T +  PV    
Sbjct: 1328 TAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEP 1387

Query: 788  ILSPLRDHENLKNLWVKIDLDLLSRVP--GHSSLHAAPAKPDHKETATKPK-RQTAVTAV 844
                 R  +N  +   K    L+   P    S+    P  P+    AT+ +  +++V   
Sbjct: 1388 TSRATRGRKNRSS--GKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTP 1445

Query: 845  EKPAPKGKRKH-----------KPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPP 893
            E   P                 +P   A +    +  ++   T+    P +  +     P
Sbjct: 1446 ETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQP 1505

Query: 894  NTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTK 953
             T E  +SR    RK       P + +P  P  + + S +     +  + A  G+   + 
Sbjct: 1506 VTSE-PTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSS 1564

Query: 954  PKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATAT 1013
             K  E         + +     P  + +  +T   T+ AT   T  + V T      TA 
Sbjct: 1565 VKTPESI-------VPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAP 1617

Query: 1014 ATTTTTTT 1021
                TT+T
Sbjct: 1618 EPHPTTST 1625



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 86/408 (21%), Positives = 138/408 (33%), Gaps = 32/408 (7%)

Query: 301  ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTK------LPKFTILQTSEVSLPSDP 354
            I+P L PS   E             G+ + +S KT        PK     +++  +  +P
Sbjct: 1369 IAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEP 1428

Query: 355  SCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRAST 414
            +      R    S  TP T + TA   + ST +      Q +TP  T Q     T R+S 
Sbjct: 1429 TSQATRGRTNRSSVKTPETVVPTAPELQPSTST-----DQPVTPEPTSQATRGRTDRSSV 1483

Query: 415  KSVSFKSMLEDDLKLSSDEDD---LEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLAT 471
            K+         +L+ S+  D     EP    T         +  E   P    + P  +T
Sbjct: 1484 KTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTST 1543

Query: 472  PQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLD 531
             QP      S  +   +   S    +S    +     S    ++ TPEP   +T      
Sbjct: 1544 DQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATR----- 1598

Query: 532  KWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQ-MKVKTNASQVPAEPKERPLLS 590
               N+ + +    +      P  T S   P+   +  +  + KTN S V       P  S
Sbjct: 1599 CRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAAS 1658

Query: 591  LIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNI 650
             + E   P      PE  A +   S T  + + R +      + +   +TD+   P+P  
Sbjct: 1659 DL-EPFTPTDQSVTPEAIA-QGGQSKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPIT 1716

Query: 651  TSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYR 698
              S  K + +      P        HKP        + PL P+ +  R
Sbjct: 1717 QPSCIKRQRAA---GNPGSLAAPIDHKPC-------SAPLEPKSQASR 1754


>gi|239758058 PREDICTED: similar to mucin, partial [Homo sapiens]
          Length = 967

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 168/806 (20%), Positives = 269/806 (33%), Gaps = 109/806 (13%)

Query: 278  TSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKL 337
            TS      T+ +   + +  +P I  +   +IE   S    SF +L+    + + S    
Sbjct: 201  TSHSNPSLTSAITTTETRSHSPPIFTSSITTIE-TTSHSTPSFTSLMTTTETTSLSP--- 256

Query: 338  PKFTI-LQTSEVSLPSDPSCVEEILREMTHSWPTP-----LTSMHTAGHSEQSTFSI--P 389
            P FT  + T+E +  S PS    I    T S   P     +T+  +  HS  S  S+   
Sbjct: 257  PAFTFSISTTETNSHSPPSFTSSIATTETPSHSPPSFTSLITTTESTSHSPLSFTSVITT 316

Query: 390  GQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTAT 449
             + + H TP FT       TT  S    SF S++      ++ E       + T+  TAT
Sbjct: 317  TESTSHSTPSFTSSIATTETT--SHTPPSFTSLI------TTTETPSHSNPSFTSLITAT 368

Query: 450  ELYQAVEKAKPRNNPVNPPL-----ATPQPPPAVQASGGSGSSSESESSSESDSDTESST 504
            E   +   + P              +TP     +  +  +  S+ S +SS + ++T S +
Sbjct: 369  E---STSHSPPSFTSAIATTGITSHSTPIFTSLIATTDSTSHSTPSFTSSITSTETISHS 425

Query: 505  TDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQ 564
            T S S+      T     PS           K T  N S     ++           I Q
Sbjct: 426  TPSFSSLITATKTTSHSTPSLTSLITT---TKSTPHNASSFTSYSQLHFFDHHHRGHIPQ 482

Query: 565  PMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRP--TQKIPETKALKHKL-STTSETV 621
              ++      N   +    +   L++  +  +   P  T  I  TK   H   S TS   
Sbjct: 483  YSQLDFFDHYNRDHLT---QFTSLITTTKTTSHSPPSFTALITSTKTTSHSTPSFTSSIA 539

Query: 622  SQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPR 681
            +  T     P     +T+T+  +   P  +SS    K +     PPR        K    
Sbjct: 540  TTETTSHSPPSFTSSSTTTETHSHSTPGFSSSIATSKTTST--SPPRFTFAIATTKTTLH 597

Query: 682  KEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGG 741
              PR  + +A  K          P     I T  +TS              L   I + G
Sbjct: 598  STPRFTLAIASTKTTSHS----TPSLTSLITTIETTSHCTPS---------LTSSITTSG 644

Query: 742  NTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIP-----VMQTEILSPLRDHE 796
              + S     + +T++   S S ++   SI+  E T    P     +  TEI+S      
Sbjct: 645  TISHSTPSFTSLITITESTSHSTTSFPSSITTTETTSHSTPSFTSLIATTEIIS------ 698

Query: 797  NLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHK 856
                             P ++S  A    P H  T + P   T    +    P       
Sbjct: 699  --------------HSTPSYTSSIATTETPSHS-TPSFPFSITTTETIPHSTPSLNSAIT 743

Query: 857  PIE-VAEKIPEKKQRLEEATTICLLPP------CISPAPPHKPPNTRENNSSRRANRRKE 909
              E ++  IP     +  + T    PP        +    H PP+   + +S  A     
Sbjct: 744  TTETMSHSIPGFASSITTSETTSPFPPRFTSLITTTKTTSHSPPSFTASLTSTEATSHSP 803

Query: 910  -------------EKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIA-MTGQITS---- 951
                          +  P   S +        N  G +      K  +  T   TS    
Sbjct: 804  LSFTSVIASTKITSQSTPSLTSLITTTGTSSHNTLGLSSSVDTTKTTSHSTASFTSLIAT 863

Query: 952  --TKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTAT 1009
              T    T G F ++     +    TP   SS T   T +  + +  +   I  +T  +T
Sbjct: 864  TETTSHNTPG-FTSSIATTEITSHSTPSFTSSITTMETTSRSSPSFTSLITITGSTSHST 922

Query: 1010 ATATATTTTTTTT---ISTITSTITT 1032
            A+ T++ TTT TT     +ITS++TT
Sbjct: 923  ASFTSSITTTETTSHSTPSITSSVTT 948



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 108/489 (22%), Positives = 170/489 (34%), Gaps = 63/489 (12%)

Query: 333 SKTKLPKFT-ILQTSEVSLPSDPSCVEEILREMTHSWPTP-----LTSMHTAGHSEQS-- 384
           ++  L +FT ++ T++ +  S PS    I    T S  TP     + +  T  HS  S  
Sbjct: 493 NRDHLTQFTSLITTTKTTSHSPPSFTALITSTKTTSHSTPSFTSSIATTETTSHSPPSFT 552

Query: 385 TFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTT 444
           + S   +   H TPGF+       TT  S    +F          S+    L    T TT
Sbjct: 553 SSSTTTETHSHSTPGFSSSIATSKTTSTSPPRFTFAIATTKTTLHSTPRFTLAIASTKTT 612

Query: 445 QCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSES--------ESSSES 496
             +   L   +   +  ++       TP    ++  SG    S+ S        ES+S S
Sbjct: 613 SHSTPSLTSLITTIETTSH------CTPSLTSSITTSGTISHSTPSFTSLITITESTSHS 666

Query: 497 DSDTESS--TTDSESNEAPR----VATPEPEPPSTNKWQLDKWLNKVTSQNKS---FICG 547
            +   SS  TT++ S+  P     +AT E    ST  +       +  S +     F   
Sbjct: 667 TTSFPSSITTTETTSHSTPSFTSLIATTEIISHSTPSYTSSIATTETPSHSTPSFPFSIT 726

Query: 548 QNET-PMETISLPPPIIQPMEVQMKVKTNASQV-------PAEPKERPLLSLIREKARPR 599
             ET P  T SL   I     +   +   AS +       P  P+   L++  +  +   
Sbjct: 727 TTETIPHSTPSLNSAITTTETMSHSIPGFASSITTSETTSPFPPRFTSLITTTKTTSHSP 786

Query: 600 P--TQKIPETKALKHK-LSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPK 656
           P  T  +  T+A  H  LS TS   S +   +  P      T+T   +     ++SS   
Sbjct: 787 PSFTASLTSTEATSHSPLSFTSVIASTKITSQSTPSLTSLITTTGTSSHNTLGLSSSVDT 846

Query: 657 EKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPG---KIVPKSREFIET 713
                          K T+H  A       ++    E   +  PG    I         T
Sbjct: 847 --------------TKTTSHSTASFT----SLIATTETTSHNTPGFTSSIATTEITSHST 888

Query: 714 DSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISN 773
            S TS   T +  +         I   G+T+ S     +S+T +   S S  +   S++ 
Sbjct: 889 PSFTSSITTMETTSRSSPSFTSLITITGSTSHSTASFTSSITTTETTSHSTPSITSSVTT 948

Query: 774 EEPTFSPIP 782
            E TF   P
Sbjct: 949 AERTFHSTP 957



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 118/616 (19%), Positives = 205/616 (33%), Gaps = 90/616 (14%)

Query: 486  SSSESESSSESDSDTESSTTDSESNEAP----RVATPEPEPPSTNKWQLDKWLNKVTSQN 541
            +++E  S S     + S+TT++ S+  P     +AT E    ST  +       +  SQN
Sbjct: 26   ATTEITSHSPPSFTSSSTTTETPSHSTPGFSSSIATTETTSHSTASFTSSIATTETMSQN 85

Query: 542  -KSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRP 600
               F      T + + S P            + T  +   + P    L+++         
Sbjct: 86   IPGFTSSIATTEITSHSTP-------SFTSSITTTETTSQSSPSFTSLITI--------- 129

Query: 601  TQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 660
            T     + A      TT+ET S  T          K TS    ++     TS TP     
Sbjct: 130  TGSTSHSTASFTSSITTTETTSHSTRSITSSITTTKRTSHSSLSYTSSIATSETPS---- 185

Query: 661  VELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS 720
               H  P   +  T  +      P     +   + +   P  I   S   IET S ++ S
Sbjct: 186  ---HTVPSFTSLITTTESTSHSNPSLTSAITTTETRSHSP-PIFTSSITTIETTSHSTPS 241

Query: 721  NTDQEETLQIKVL-PPCIISGGNTAKSKEICGASLTLSTLMSSSGSNN-----NLSISNE 774
             T    T +   L PP      +T ++      S T S   + + S++     +L  + E
Sbjct: 242  FTSLMTTTETTSLSPPAFTFSISTTETNSHSPPSFTSSIATTETPSHSPPSFTSLITTTE 301

Query: 775  EPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV-PGHSSLHAAPAKPDHKETAT 833
              + SP+        +    H            +  S   P  +SL      P H    +
Sbjct: 302  STSHSPLSFTSVITTTESTSHSTPSFTSSIATTETTSHTPPSFTSLITTTETPSH----S 357

Query: 834  KPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPP 893
             P   + +TA E  +      H P      I         +T I       + +  H  P
Sbjct: 358  NPSFTSLITATESTS------HSPPSFTSAI-ATTGITSHSTPIFTSLIATTDSTSHSTP 410

Query: 894  NTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTK 953
            +   + +S             P  S L          + ++ P       ++T  IT+TK
Sbjct: 411  SFTSSITSTETISHS-----TPSFSSL----ITATKTTSHSTP-------SLTSLITTTK 454

Query: 954  PKRTEGKFCATFKGISV----NEGDTPKKAS---------------SATITVTNTA---- 990
                      ++  +      + G  P+ +                ++ IT T T     
Sbjct: 455  STPHNASSFTSYSQLHFFDHHHRGHIPQYSQLDFFDHYNRDHLTQFTSLITTTKTTSHSP 514

Query: 991  -IATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALP 1049
               TA +T+T   + +  +  ++ ATT TT+ +  + TS+ TT     +H   T   +  
Sbjct: 515  PSFTALITSTKTTSHSTPSFTSSIATTETTSHSPPSFTSSSTT---TETHSHSTPGFSSS 571

Query: 1050 LLSSSSTNVRRPKLTF 1065
            + +S +T+   P+ TF
Sbjct: 572  IATSKTTSTSPPRFTF 587



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 90/394 (22%), Positives = 138/394 (35%), Gaps = 62/394 (15%)

Query: 329 SAASSKT---KLPKFTI-LQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQS 384
           S A+++T    +P FT  + T+E++  S PS    I    T S  +P         S  S
Sbjct: 75  SIATTETMSQNIPGFTSSIATTEITSHSTPSFTSSITTTETTSQSSP---------SFTS 125

Query: 385 TFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFK---------SMLEDDLKLSSDEDD 435
             +I G  S H T  FT       TT  ST+S++           S L     +++ E  
Sbjct: 126 LITITGSTS-HSTASFTSSITTTETTSHSTRSITSSITTTKRTSHSSLSYTSSIATSETP 184

Query: 436 LEPVKTLTTQCTATE--------LYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSS 487
              V + T+  T TE        L  A+   + R++  +PP+ T         S  + S 
Sbjct: 185 SHTVPSFTSLITTTESTSHSNPSLTSAITTTETRSH--SPPIFTSSITTIETTSHSTPSF 242

Query: 488 SESESSSESDSDTES------STTDSESNEAPRVA-------TPEPEPPSTNKWQLDKWL 534
           +   +++E+ S +        STT++ S+  P          TP   PPS     L    
Sbjct: 243 TSLMTTTETTSLSPPAFTFSISTTETNSHSPPSFTSSIATTETPSHSPPSFT--SLITTT 300

Query: 535 NKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIRE 594
              +    SF      T   + S P            + T  +     P    L++    
Sbjct: 301 ESTSHSPLSFTSVITTTESTSHSTP-------SFTSSIATTETTSHTPPSFTSLITTTET 353

Query: 595 KARPRP--TQKIPETKALKHK-LSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNIT 651
            +   P  T  I  T++  H   S TS   +        P       +TD  +   P+ T
Sbjct: 354 PSHSNPSFTSLITATESTSHSPPSFTSAIATTGITSHSTPIFTSLIATTDSTSHSTPSFT 413

Query: 652 SS-TPKEKESVELHDPPRGRNKATAHKPAPRKEP 684
           SS T  E  S   H  P   +  TA K      P
Sbjct: 414 SSITSTETIS---HSTPSFSSLITATKTTSHSTP 444



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 45/152 (29%), Positives = 63/152 (41%), Gaps = 39/152 (25%)

Query: 944  AMTGQITSTKP-KRTEGKFCATFKGISVNEGDTPKKASSATITVTNT--------AIATA 994
            + T  ITSTK    +   F ++           P   SS+T T T++        +IAT+
Sbjct: 516  SFTALITSTKTTSHSTPSFTSSIATTETTSHSPPSFTSSSTTTETHSHSTPGFSSSIATS 575

Query: 995  TVTAT-------AIVTTTVTATAT-----ATATTTTTT----------TTIST------- 1025
              T+T       AI TT  T  +T     A A+T TT+          TTI T       
Sbjct: 576  KTTSTSPPRFTFAIATTKTTLHSTPRFTLAIASTKTTSHSTPSLTSLITTIETTSHCTPS 635

Query: 1026 ITSTITT-GLMDSSHLEMTSWAALPLLSSSST 1056
            +TS+ITT G +  S    TS   +   +S ST
Sbjct: 636  LTSSITTSGTISHSTPSFTSLITITESTSHST 667


>gi|239749510 PREDICTED: hypothetical protein, partial [Homo sapiens]
          Length = 108

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 29/79 (36%), Positives = 42/79 (53%), Gaps = 1/79 (1%)

Query: 983  TITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEM 1042
            T T+TNT     T T   I TTT+  T T T TTT T TT +T+T T TT +  ++   M
Sbjct: 24   TTTITNTTTTNTTTTTITITTTTIAMTTTTTTTTTMTITTTTTMTITTTT-MTTTTTTTM 82

Query: 1043 TSWAALPLLSSSSTNVRRP 1061
            T+     + ++++T    P
Sbjct: 83   TTTTITSITNTTTTTTMTP 101



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 30/68 (44%), Positives = 39/68 (57%), Gaps = 1/68 (1%)

Query: 969  SVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTT-TTTTISTIT 1027
            + N   T    ++ TI +T T   T T+T T   T T+T T   T TTTT TTTTI++IT
Sbjct: 32   TTNTTTTTITITTTTIAMTTTTTTTTTMTITTTTTMTITTTTMTTTTTTTMTTTTITSIT 91

Query: 1028 STITTGLM 1035
            +T TT  M
Sbjct: 92   NTTTTTTM 99



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 1/92 (1%)

Query: 981  SATITVTNTAIATATV-TATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSH 1039
            + TIT+T T   T T+ T T  +TTT+T T T   TTTT T T +TI  T TT    +  
Sbjct: 1    TTTITITTTTTTTTTIITTTMTITTTITNTTTTNTTTTTITITTTTIAMTTTTTTTTTMT 60

Query: 1040 LEMTSWAALPLLSSSSTNVRRPKLTFDDSVHN 1071
            +  T+   +   + ++T       T   S+ N
Sbjct: 61   ITTTTTMTITTTTMTTTTTTTMTTTTITSITN 92



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 36/95 (37%), Positives = 48/95 (50%), Gaps = 3/95 (3%)

Query: 946  TGQITSTKPKRTEGKFCATFKGISVN-EGDTPKKASSATITVTNTAIATATVTATAIVTT 1004
            T  IT T    T      T   I+      T    ++ TIT+T T IA  T T T   T 
Sbjct: 1    TTTITITTTTTTTTTIITTTMTITTTITNTTTTNTTTTTITITTTTIAMTTTTTTT-TTM 59

Query: 1005 TVTATATATATTTT-TTTTISTITSTITTGLMDSS 1038
            T+T T T T TTTT TTTT +T+T+T  T + +++
Sbjct: 60   TITTTTTMTITTTTMTTTTTTTMTTTTITSITNTT 94



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 33/90 (36%), Positives = 45/90 (50%), Gaps = 5/90 (5%)

Query: 980  SSATITVTNTAIATATVTATAI-VTTTVTATATATATTTT---TTTTISTITSTI-TTGL 1034
            ++ T T T     T T+T T    TTT T T T T TTTT   TTTT +T T TI TT  
Sbjct: 7    TTTTTTTTTIITTTMTITTTITNTTTTNTTTTTITITTTTIAMTTTTTTTTTMTITTTTT 66

Query: 1035 MDSSHLEMTSWAALPLLSSSSTNVRRPKLT 1064
            M  +   MT+     + +++ T++     T
Sbjct: 67   MTITTTTMTTTTTTTMTTTTITSITNTTTT 96



 Score = 38.5 bits (88), Expect = 0.043
 Identities = 23/53 (43%), Positives = 30/53 (56%), Gaps = 2/53 (3%)

Query: 975  TPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTIT 1027
            T    ++ T+T+T T   T T T T   TTT T T T T T+ T TTT +T+T
Sbjct: 50   TTTTTTTTTMTITTTTTMTITTT-TMTTTTTTTMT-TTTITSITNTTTTTTMT 100


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 79/329 (24%), Positives = 122/329 (37%), Gaps = 53/329 (16%)

Query: 424 EDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPL---ATPQPPPAVQA 480
           E+D + SS+E D +            +      + KP +     PL   A P PP  V  
Sbjct: 395 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP 454

Query: 481 SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 540
           +  S    + E  SES S+  S   DS   E P    P  E    N  Q      K TS 
Sbjct: 455 ATPSAQVGKWEEDSESSSEESS---DSSDGEVPTAVAPAQEKSLGNILQA-----KPTS- 505

Query: 541 NKSFICGQNETPMETISLPPPIIQPMEVQMKVK-----TNASQVPAEPKERPLLSLIREK 595
                     +P +    PP    P+ VQ+K +     + +S+  ++  +          
Sbjct: 506 ----------SPAKG---PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 552

Query: 596 ARPRPTQKIPETKALKHKLSTT-SETVSQRTIGKKQPKKVEKNTSTDEFT------WPKP 648
           A+ +P  KIP+TKA   K +TT S  V+   +G + P+K    TS    +        +P
Sbjct: 553 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 612

Query: 649 NITSSTPKEKESVE-----------LHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKY 697
              SS+ +E +S E                +G     A  P      +   P+ P K   
Sbjct: 613 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK--- 669

Query: 698 RGPGKIVPKSREFIETDSSTSDSNTDQEE 726
              G  V + +   + DS +S+  +D EE
Sbjct: 670 --TGPTVTQVKAEKQEDSESSEEESDSEE 696



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 151/789 (19%), Positives = 259/789 (32%), Gaps = 156/789 (19%)

Query: 192 KLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSP-----------E 240
           K E+     A++ ++ +   ++ S++E+    +    A   +  +NS            E
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 241 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 300
           +++   +  G     +S+  P++G +V N   G   + S      T  V   + +   P 
Sbjct: 124 KAKAETEKAGK--TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181

Query: 301 ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI 360
                KP             G +  G+  ++S  T         +S      +    E+I
Sbjct: 182 FGAAAKP-------------GMVSAGQADSSSEDTS--------SSSDETDVEVKASEKI 220

Query: 361 LREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFK 420
           L+    S P   T               PG+ +    PG            + TK+   +
Sbjct: 221 LQVRAASAPAKGT---------------PGKGATPAPPG------KAGAVASQTKAGKPE 259

Query: 421 SMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPP----P 476
              E   + SSD ++  P      Q  A+     V  A           A P PP    P
Sbjct: 260 EDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGP 319

Query: 477 AV-QASGGSGSSSESESSSESDSDTESSTTDSESNEAPRV-ATPEPEPPSTNKWQLDKWL 534
           AV +A  G        SS ESDS+ E+      S +AP+V A   P   S  K       
Sbjct: 320 AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK------- 372

Query: 535 NKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIRE 594
                       G    P        P    ++V  + + + S       +R  L+ +  
Sbjct: 373 ------------GAAPAPPRKTG---PAAAQVQVGKQEEDSRSSSEESDSDREALAAM-N 416

Query: 595 KARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSST 654
            A+ +P  K P+ K      ST       +  G   P KV   T + +    + +  SS+
Sbjct: 417 AAQVKPLGKSPQVK----PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSS 472

Query: 655 PKEKESVELHDPPRGRNKATAHKPAPRK------EPRPNIPLAPEKKKYRGPGKIVPKSR 708
            +  +S +   P       TA  PA  K      + +P    A    +  GP  +  K+ 
Sbjct: 473 EESSDSSDGEVP-------TAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 525

Query: 709 EFIETDSSTSDS--NTDQEE------------TLQIKVLPPCIISGGNTAKSKEI----- 749
           + ++   S+ +S  + D EE             L+I     C      TA +K       
Sbjct: 526 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 585

Query: 750 CGASLTLSTLMSSSG----------------SNNNLSISNEEPTFSPIPVMQTEILSPLR 793
             A     T  S +G                S++  S S EE T   + V Q + +    
Sbjct: 586 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG--- 642

Query: 794 DHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKR 853
                K L VK     +    G  +    P K     T  K ++Q    + E+ +   + 
Sbjct: 643 -----KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 697

Query: 854 KHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTREN---NSSRRANRRKEE 910
              P +V   + + + +           P  + AP  K   +       ++ +A +R   
Sbjct: 698 AASPAQVKTSVKKTQAKAN---------PAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 748

Query: 911 KLFPPPLSP 919
           K+ PP  +P
Sbjct: 749 KVKPPVRNP 757



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 176/889 (19%), Positives = 299/889 (33%), Gaps = 157/889 (17%)

Query: 201  AEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLA 260
            A Q Q+G+ EE + S+ E+S+ +     A       N+ +           P  AS++  
Sbjct: 386  AAQVQVGKQEEDSRSSSEESDSDREALAAM------NAAQVKPLGKSPQVKP--ASTMGM 437

Query: 261  PSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFG---N 317
               G      PPG      +G   P+A V   +   ++     +     E   +      
Sbjct: 438  GPLGKGAGPVPPG-----KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 492

Query: 318  LSFGTLLDGKPSAASSK----------TKLPKFTILQTSEVS-LPSDPSCVEEILREMTH 366
             S G +L  KP+++ +K           ++     +  SE S   SD +  EE    MT 
Sbjct: 493  KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 552

Query: 367  SWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTT--RASTKSVSFKSMLE 424
            +   P   +       + T +    +   +  G    +     T    S+ +V+  +   
Sbjct: 553  AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 612

Query: 425  DDLKLSSDEDDLEPVKT--LTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASG 482
             +   SS+E D E  KT    T   A  + + ++  K  + PV   L     P       
Sbjct: 613  AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ-VKAASVPVKGSLGQGTAP----VLP 667

Query: 483  GSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNK 542
            G    + ++  +E   D+ESS  +S+S EA   A+P     S  K          T    
Sbjct: 668  GKTGPTVTQVKAEKQEDSESSEEESDSEEA--AASPAQVKTSVKK----------TQAKA 715

Query: 543  SFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQ 602
            +    +  +   TIS P           KV T A+Q              R  ++ +P  
Sbjct: 716  NPAAARAPSAKGTISAPG----------KVVTAAAQAKQ-----------RSPSKVKPPV 754

Query: 603  KIPE--TKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 660
            + P+  T   +   S  S   +  T  + Q    E + S++E          S  +E+  
Sbjct: 755  RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE---------ESDSEEEAE 805

Query: 661  VELHDPPRGRNKATAHKPAPRKE-PRPNIPLAPEKKKYRGPGKIVPKSREFIETD---SS 716
                  P G+        AP KE PR      P       PGK  P + +  + D   SS
Sbjct: 806  TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-------PGKTGPSAAQAGKQDDSGSS 858

Query: 717  TSDSNTDQEETLQIK----VLPPCII------SGGNTAKSKEICGASLTLSTLMSSSGSN 766
            + +S++D E    +     + PP I         G  A   +   AS       S S + 
Sbjct: 859  SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 918

Query: 767  NNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKP 826
            ++ S S +E       +  T+ L+P                 + + V    + H   A  
Sbjct: 919  SSSSESEDEDV-----IPATQCLTP----------------GIRTNVVTMPTAHPRIAPK 957

Query: 827  DHKETATKPKRQTAVTAVEKPAPKGKRKHKP-IEVAEKIPEKKQRLEEATTICLLPPCIS 885
                 A+  K  + ++        GK++  P  +V++K P      + A     L     
Sbjct: 958  ASMAGASSSKESSRIS-------DGKKQEGPATQVSKKNPASLPLTQAA-----LKVLAQ 1005

Query: 886  PAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAM 945
             A   +PP  R   SS               +  LP   P+  +V        +   +  
Sbjct: 1006 KASEAQPPVARTQPSSG----------VDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPE 1055

Query: 946  TGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTT 1005
              Q T       + +  +     S  +G+ P+ A SA   V  T   T T+         
Sbjct: 1056 VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETL--------- 1106

Query: 1006 VTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSS 1054
            V  TA  ++       + S ++  +T GL  ++     +  A P L SS
Sbjct: 1107 VEETAAESSEDDVVAPSQSLLSGYMTPGLTPAN---SQASKATPKLDSS 1152



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 75/346 (21%), Positives = 129/346 (37%), Gaps = 52/346 (15%)

Query: 200  PAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAP--GSPLVASS 257
            PA  P +G+   +  +A+  + P    ED+     +S+S EE+E   Q    G      +
Sbjct: 767  PASVPSVGKAVAT--AAQAQTGPE---EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRA 821

Query: 258  LLAPSSGLSVQNFPPGLYCKTSMG------QQKPTAYVRPMDGQDQAPDI---SPTLKPS 308
             LAP+     +   P    KT         Q    +     D   +AP     +  +KP 
Sbjct: 822  ALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPP 881

Query: 309  IEFENSFGNLSFGTLLDGKPSAASS--KTKLPKFTILQTSEVSLPSD----PSCVEEILR 362
            + F +   + +       +  AAS+  K +  + T   +S  S   D      C+   +R
Sbjct: 882  LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 941

Query: 363  EMTHSWPT------PLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKS 416
                + PT      P  SM  A  S+         ES  ++ G   +K   P T+ S K+
Sbjct: 942  TNVVTMPTAHPRIAPKASMAGASSSK---------ESSRISDG---KKQEGPATQVSKKN 989

Query: 417  VSFKSMLEDDLK-LSSDEDDLEPVKTLTTQCTATE-LYQAVEKAKPRNNPVNPP----LA 470
             +   + +  LK L+    + +P    T   +  +     +    P++  V       L 
Sbjct: 990  PASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLR 1049

Query: 471  TPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVA 516
             P+ P   QA+         ESS +S+  ++SS+   E  E P+ A
Sbjct: 1050 KPKLPEVQQAT------KAPESSDDSEDSSDSSSGSEEDGEGPQGA 1089


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 79/329 (24%), Positives = 122/329 (37%), Gaps = 53/329 (16%)

Query: 424 EDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPL---ATPQPPPAVQA 480
           E+D + SS+E D +            +      + KP +     PL   A P PP  V  
Sbjct: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP 531

Query: 481 SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 540
           +  S    + E  SES S+  S   DS   E P    P  E    N  Q      K TS 
Sbjct: 532 ATPSAQVGKWEEDSESSSEESS---DSSDGEVPTAVAPAQEKSLGNILQA-----KPTS- 582

Query: 541 NKSFICGQNETPMETISLPPPIIQPMEVQMKVK-----TNASQVPAEPKERPLLSLIREK 595
                     +P +    PP    P+ VQ+K +     + +S+  ++  +          
Sbjct: 583 ----------SPAKG---PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 596 ARPRPTQKIPETKALKHKLSTT-SETVSQRTIGKKQPKKVEKNTSTDEFT------WPKP 648
           A+ +P  KIP+TKA   K +TT S  V+   +G + P+K    TS    +        +P
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689

Query: 649 NITSSTPKEKESVE-----------LHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKY 697
              SS+ +E +S E                +G     A  P      +   P+ P K   
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK--- 746

Query: 698 RGPGKIVPKSREFIETDSSTSDSNTDQEE 726
              G  V + +   + DS +S+  +D EE
Sbjct: 747 --TGPTVTQVKAEKQEDSESSEEESDSEE 773



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 156/826 (18%), Positives = 270/826 (32%), Gaps = 153/826 (18%)

Query: 192 KLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSP-----------E 240
           K E+     A++ ++ +   ++ S++E+    +    A   +  +NS            E
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 241 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 300
           +++   +  G     +S+  P++G +V N   G   + S      T  V   + +   P 
Sbjct: 124 KAKAETEKAGK--TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181

Query: 301 ISPTLKPSI-------EFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSD 353
                KP +              + S  T ++GKPS   ++ K    +  ++        
Sbjct: 182 FGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA 241

Query: 354 PSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQ---------- 403
           P  V ++  ++      P  +       E+S  S  G ES+   P  T            
Sbjct: 242 PGKVGDVTPQVKGGALPP--AKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299

Query: 404 -------------KWNDPT-------TRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLT 443
                        K   P          + TK+   +   E   + SSD ++  P     
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359

Query: 444 TQCTATELYQAVEKAKPRNNPVNPPLATPQPP----PAV-QASGGSGSSSESESSSESDS 498
            Q  A+     V  A           A P PP    PAV +A  G        SS ESDS
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419

Query: 499 DTESSTTDSESNEAPRV-ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETIS 557
           + E+      S +AP+V A   P   S  K                   G    P     
Sbjct: 420 EEEAPAQAKPSGKAPQVRAASAPAKESPRK-------------------GAAPAPPRKTG 460

Query: 558 LPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTT 617
              P    ++V  + + + S       +R  L+ +   A+ +P  K P+ K      ST 
Sbjct: 461 ---PAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVK----PASTM 512

Query: 618 SETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHK 677
                 +  G   P KV   T + +    + +  SS+ +  +S +   P       TA  
Sbjct: 513 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP-------TAVA 565

Query: 678 PAPRK------EPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS--NTDQEE--- 726
           PA  K      + +P    A    +  GP  +  K+ + ++   S+ +S  + D EE   
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA 625

Query: 727 ---------TLQIKVLPPCIISGGNTAKSKEI-----CGASLTLSTLMSSSG-------- 764
                     L+I     C      TA +K         A     T  S +G        
Sbjct: 626 AMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 685

Query: 765 --------SNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGH 816
                   S++  S S EE T   + V Q + +         K L VK     +    G 
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG--------KGLQVKAASVPVKGSLGQ 737

Query: 817 SSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATT 876
            +    P K     T  K ++Q    + E+ +   +    P +V   + + + +      
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN---- 793

Query: 877 ICLLPPCISPAPPHKPPNTREN---NSSRRANRRKEEKLFPPPLSP 919
                P  + AP  K   +       ++ +A +R   K+ PP  +P
Sbjct: 794 -----PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNP 834



 Score = 38.1 bits (87), Expect = 0.056
 Identities = 148/717 (20%), Positives = 244/717 (34%), Gaps = 109/717 (15%)

Query: 201  AEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLA 260
            A Q Q+G+ EE + S+ E+S+ +     A       N+ +           P  AS++  
Sbjct: 463  AAQVQVGKQEEDSRSSSEESDSDREALAAM------NAAQVKPLGKSPQVKP--ASTMGM 514

Query: 261  PSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFG---N 317
               G      PPG      +G   P+A V   +   ++     +     E   +      
Sbjct: 515  GPLGKGAGPVPPG-----KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569

Query: 318  LSFGTLLDGKPSAASSK----------TKLPKFTILQTSEVS-LPSDPSCVEEILREMTH 366
             S G +L  KP+++ +K           ++     +  SE S   SD +  EE    MT 
Sbjct: 570  KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 367  SWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTT--RASTKSVSFKSMLE 424
            +   P   +       + T +    +   +  G    +     T    S+ +V+  +   
Sbjct: 630  AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689

Query: 425  DDLKLSSDEDDLEPVKT--LTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASG 482
             +   SS+E D E  KT    T   A  + + ++  K  + PV   L     P       
Sbjct: 690  AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ-VKAASVPVKGSLGQGTAP----VLP 744

Query: 483  GSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNK 542
            G    + ++  +E   D+ESS  +S+S EA   A+P     S  K          T    
Sbjct: 745  GKTGPTVTQVKAEKQEDSESSEEESDSEEA--AASPAQVKTSVKK----------TQAKA 792

Query: 543  SFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQ 602
            +    +  +   TIS P           KV T A+Q              R  ++ +P  
Sbjct: 793  NPAAARAPSAKGTISAPG----------KVVTAAAQAKQ-----------RSPSKVKPPV 831

Query: 603  KIPE--TKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 660
            + P+  T   +   S  S   +  T  + Q    E + S++E          S  +E+  
Sbjct: 832  RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE---------ESDSEEEAE 882

Query: 661  VELHDPPRGRNKATAHKPAPRKE-PRPNIPLAPEKKKYRGPGKIVPKSREFIETD---SS 716
                  P G+        AP KE PR      P       PGK  P + +  + D   SS
Sbjct: 883  TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-------PGKTGPSAAQAGKQDDSGSS 935

Query: 717  TSDSNTDQEETLQIK----VLPPCII------SGGNTAKSKEICGASLTLSTLMSSSGSN 766
            + +S++D E    +     + PP I         G  A   +   AS       S S + 
Sbjct: 936  SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 995

Query: 767  NNLSISNEE----PTFSPIPVMQTEILSPLRDHENL--KNLWVKIDLDLLSRVPGHSSLH 820
            ++ S S +E     T    P ++T +++    H  +  K           S         
Sbjct: 996  SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQ 1055

Query: 821  AAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEV--AEKIPEKKQRLEEAT 875
              PA        T P      T+V+       RK K  EV  A K PE     E+++
Sbjct: 1056 EGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1112



 Score = 34.7 bits (78), Expect = 0.62
 Identities = 158/745 (21%), Positives = 264/745 (35%), Gaps = 145/745 (19%)

Query: 198  VYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASS 257
            V PA++  +G + ++ P++     P         ++      + SE + ++  S   A S
Sbjct: 564  VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS---ADS 620

Query: 258  LLAPSSGLSVQNFPPGLYCKTSMGQQKP----TAYVRPMDGQDQAPDISPTLKPSIEFEN 313
              AP++  + Q  P     +T    +K     +A V P+    QAP  + T         
Sbjct: 621  EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGT--------- 671

Query: 314  SFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLT 373
                    T   G   A +  T+ P       +E S  S+ S  EE   E T    T   
Sbjct: 672  -------ATSPAGSSPAVAGGTQRP-------AEDSSSSEESDSEE---EKTGLAVTVGQ 714

Query: 374  SMHTAGHSEQSTFSIP-----GQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLK 428
            +       +    S+P     GQ +  + PG T      PT          K+  ++D +
Sbjct: 715  AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKT-----GPTV------TQVKAEKQEDSE 763

Query: 429  LSSDEDDLEP-------VKTLT--TQCTAT-----------------ELYQAVEKAKPRN 462
             S +E D E        VKT    TQ  A                  ++  A  +AK R+
Sbjct: 764  SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 823

Query: 463  -NPVNPPLATPQP-------PPAVQASGGS-GSSSESESSSESDSDTESSTTDSESNEAP 513
             + V PP+  PQ        P +V + G +  +++++++  E DS +    +DSE  EA 
Sbjct: 824  PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE-EEAE 882

Query: 514  RVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVK 573
             +A  +P              +  T Q ++ +    E+P +  +  PP           K
Sbjct: 883  TLAQVKP--------------SGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928

Query: 574  TNASQVPAEPK----ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKK 629
             + S   +E      E P      +  +P P   +   ++     +T ++  +  T    
Sbjct: 929  QDDSGSSSEESDSDGEAPAAVTSAQVIKP-PLIFVDPNRSPAGPAATPAQAQAAST---- 983

Query: 630  QPKKVEKNTSTDEFTWPKPNITSSTPKEKESV----ELHDPPRGRNKATAHKPAPRKEPR 685
             P+K   + ST          +SS+  E E V    +   P    N  T     PR  P+
Sbjct: 984  -PRKARASESTAR--------SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPK 1034

Query: 686  PNIPLA---------PEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPC 736
             ++  A          + KK  GP   V  +   + T  +TS  +T  +     K+  P 
Sbjct: 1035 ASMAGASSSKESSRISDGKKQEGPATQVDSA---VGTLPATSPQSTSVQAKGTNKLRKPK 1091

Query: 737  IISGGNTAKSKEICGASLTLSTLMSSSGSNNN----LSISNEEPTFSPIPVMQTEILSPL 792
            +       K+ E    S   S   SSSGS  +        +      P P  +TE L   
Sbjct: 1092 LPEVQQATKAPESSDDSEDSSD--SSSGSEEDGEGPQGAKSAHTLVGPTP-SRTETLVEE 1148

Query: 793  RDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAV--TAVEKPAPK 850
               E+ ++  V     LLS   G+ +    PA     +   K     +V  T   K  P 
Sbjct: 1149 TAAESSEDDVVAPSQSLLS---GYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPD 1205

Query: 851  GKRKHKPIEVAEKIPEKKQRLEEAT 875
            GK++ KP + A  +  K    E A+
Sbjct: 1206 GKQEAKPQQAAGMLSPKTGGKEAAS 1230


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 79/329 (24%), Positives = 122/329 (37%), Gaps = 53/329 (16%)

Query: 424 EDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPL---ATPQPPPAVQA 480
           E+D + SS+E D +            +      + KP +     PL   A P PP  V  
Sbjct: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP 531

Query: 481 SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 540
           +  S    + E  SES S+  S   DS   E P    P  E    N  Q      K TS 
Sbjct: 532 ATPSAQVGKWEEDSESSSEESS---DSSDGEVPTAVAPAQEKSLGNILQA-----KPTS- 582

Query: 541 NKSFICGQNETPMETISLPPPIIQPMEVQMKVK-----TNASQVPAEPKERPLLSLIREK 595
                     +P +    PP    P+ VQ+K +     + +S+  ++  +          
Sbjct: 583 ----------SPAKG---PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 596 ARPRPTQKIPETKALKHKLSTT-SETVSQRTIGKKQPKKVEKNTSTDEFT------WPKP 648
           A+ +P  KIP+TKA   K +TT S  V+   +G + P+K    TS    +        +P
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689

Query: 649 NITSSTPKEKESVE-----------LHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKY 697
              SS+ +E +S E                +G     A  P      +   P+ P K   
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK--- 746

Query: 698 RGPGKIVPKSREFIETDSSTSDSNTDQEE 726
              G  V + +   + DS +S+  +D EE
Sbjct: 747 --TGPTVTQVKAEKQEDSESSEEESDSEE 773



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 156/826 (18%), Positives = 270/826 (32%), Gaps = 153/826 (18%)

Query: 192 KLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSP-----------E 240
           K E+     A++ ++ +   ++ S++E+    +    A   +  +NS            E
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 241 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 300
           +++   +  G     +S+  P++G +V N   G   + S      T  V   + +   P 
Sbjct: 124 KAKAETEKAGK--TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181

Query: 301 ISPTLKPSI-------EFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSD 353
                KP +              + S  T ++GKPS   ++ K    +  ++        
Sbjct: 182 FGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA 241

Query: 354 PSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQ---------- 403
           P  V ++  ++      P  +       E+S  S  G ES+   P  T            
Sbjct: 242 PGKVGDVTPQVKGGALPP--AKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299

Query: 404 -------------KWNDPT-------TRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLT 443
                        K   P          + TK+   +   E   + SSD ++  P     
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359

Query: 444 TQCTATELYQAVEKAKPRNNPVNPPLATPQPP----PAV-QASGGSGSSSESESSSESDS 498
            Q  A+     V  A           A P PP    PAV +A  G        SS ESDS
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419

Query: 499 DTESSTTDSESNEAPRV-ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETIS 557
           + E+      S +AP+V A   P   S  K                   G    P     
Sbjct: 420 EEEAPAQAKPSGKAPQVRAASAPAKESPRK-------------------GAAPAPPRKTG 460

Query: 558 LPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTT 617
              P    ++V  + + + S       +R  L+ +   A+ +P  K P+ K      ST 
Sbjct: 461 ---PAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVK----PASTM 512

Query: 618 SETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHK 677
                 +  G   P KV   T + +    + +  SS+ +  +S +   P       TA  
Sbjct: 513 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP-------TAVA 565

Query: 678 PAPRK------EPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS--NTDQEE--- 726
           PA  K      + +P    A    +  GP  +  K+ + ++   S+ +S  + D EE   
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA 625

Query: 727 ---------TLQIKVLPPCIISGGNTAKSKEI-----CGASLTLSTLMSSSG-------- 764
                     L+I     C      TA +K         A     T  S +G        
Sbjct: 626 AMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 685

Query: 765 --------SNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGH 816
                   S++  S S EE T   + V Q + +         K L VK     +    G 
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG--------KGLQVKAASVPVKGSLGQ 737

Query: 817 SSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATT 876
            +    P K     T  K ++Q    + E+ +   +    P +V   + + + +      
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN---- 793

Query: 877 ICLLPPCISPAPPHKPPNTREN---NSSRRANRRKEEKLFPPPLSP 919
                P  + AP  K   +       ++ +A +R   K+ PP  +P
Sbjct: 794 -----PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNP 834



 Score = 38.5 bits (88), Expect = 0.043
 Identities = 77/355 (21%), Positives = 131/355 (36%), Gaps = 46/355 (12%)

Query: 200  PAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAP--GSPLVASS 257
            PA  P +G+   +  +A+  + P    ED+     +S+S EE+E   Q    G      +
Sbjct: 844  PASVPSVGKAVAT--AAQAQTGPE---EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRA 898

Query: 258  LLAPSSGLSVQNFPPGLYCKTSMG------QQKPTAYVRPMDGQDQAPDI---SPTLKPS 308
             LAP+     +   P    KT         Q    +     D   +AP     +  +KP 
Sbjct: 899  ALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPP 958

Query: 309  IEFENSFGNLSFGTLLDGKPSAASS--KTKLPKFTILQTSEVSLPSD----PSCVEEILR 362
            + F +   + +       +  AAS+  K +  + T   +S  S   D      C+   +R
Sbjct: 959  LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018

Query: 363  EMTHSWPT------PLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKS 416
                + PT      P  SM  A  S+         ES  ++ G   +K   P T+ S K+
Sbjct: 1019 TNVVTMPTAHPRIAPKASMAGASSSK---------ESSRISDG---KKQEGPATQVSKKN 1066

Query: 417  VSFKSMLEDDLK-LSSDEDDLEPVKTLTTQCTATE-LYQAVEKAKPRNNPVNPP----LA 470
             +   + +  LK L+    + +P    T   +  +     +    P++  V       L 
Sbjct: 1067 PASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLR 1126

Query: 471  TPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPST 525
             P+ P   QA+    SS +SE SS+S S +E      +  ++     P P    T
Sbjct: 1127 KPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTET 1181



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 157/802 (19%), Positives = 273/802 (34%), Gaps = 128/802 (15%)

Query: 201  AEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLA 260
            A Q Q+G+ EE + S+ E+S+ +     A       N+ +           P  AS++  
Sbjct: 463  AAQVQVGKQEEDSRSSSEESDSDREALAAM------NAAQVKPLGKSPQVKP--ASTMGM 514

Query: 261  PSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFG---N 317
               G      PPG      +G   P+A V   +   ++     +     E   +      
Sbjct: 515  GPLGKGAGPVPPG-----KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569

Query: 318  LSFGTLLDGKPSAASSK----------TKLPKFTILQTSEVS-LPSDPSCVEEILREMTH 366
             S G +L  KP+++ +K           ++     +  SE S   SD +  EE    MT 
Sbjct: 570  KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 367  SWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTT--RASTKSVSFKSMLE 424
            +   P   +       + T +    +   +  G    +     T    S+ +V+  +   
Sbjct: 630  AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689

Query: 425  DDLKLSSDEDDLEPVKT--LTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASG 482
             +   SS+E D E  KT    T   A  + + ++  K  + PV   L     P       
Sbjct: 690  AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ-VKAASVPVKGSLGQGTAP----VLP 744

Query: 483  GSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNK 542
            G    + ++  +E   D+ESS  +S+S EA   A+P     S  K          T    
Sbjct: 745  GKTGPTVTQVKAEKQEDSESSEEESDSEEA--AASPAQVKTSVKK----------TQAKA 792

Query: 543  SFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQ 602
            +    +  +   TIS P           KV T A+Q              R  ++ +P  
Sbjct: 793  NPAAARAPSAKGTISAPG----------KVVTAAAQAKQ-----------RSPSKVKPPV 831

Query: 603  KIPE--TKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 660
            + P+  T   +   S  S   +  T  + Q    E + S++E          S  +E+  
Sbjct: 832  RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE---------ESDSEEEAE 882

Query: 661  VELHDPPRGRNKATAHKPAPRKE-PRPNIPLAPEKKKYRGPGKIVPKSREFIETD---SS 716
                  P G+        AP KE PR      P       PGK  P + +  + D   SS
Sbjct: 883  TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-------PGKTGPSAAQAGKQDDSGSS 935

Query: 717  TSDSNTDQEETLQIK----VLPPCII------SGGNTAKSKEICGASLTLSTLMSSSGSN 766
            + +S++D E    +     + PP I         G  A   +   AS       S S + 
Sbjct: 936  SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 995

Query: 767  NNLSISNEE----PTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAA 822
            ++ S S +E     T    P ++T +++    H                R+   +S+  A
Sbjct: 996  SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAH---------------PRIAPKASMAGA 1040

Query: 823  PAKPDHKETATKPKRQTAVTAVEK--PAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLL 880
             +  +    +   K++   T V K  PA     +     +A+K  E +  +        +
Sbjct: 1041 SSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGV 1100

Query: 881  PPCISPAPPHKPPNT----RENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGP 936
               +   P   P +T    +  N  R+    + ++    P S   +D     + S  +  
Sbjct: 1101 DSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPES--SDDSEDSSDSSSGSEE 1158

Query: 937  FGQDKNIAMTGQITSTKPKRTE 958
             G+    A +       P RTE
Sbjct: 1159 DGEGPQGAKSAHTLGPTPSRTE 1180


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 79/329 (24%), Positives = 122/329 (37%), Gaps = 53/329 (16%)

Query: 424 EDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPL---ATPQPPPAVQA 480
           E+D + SS+E D +            +      + KP +     PL   A P PP  V  
Sbjct: 395 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP 454

Query: 481 SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 540
           +  S    + E  SES S+  S   DS   E P    P  E    N  Q      K TS 
Sbjct: 455 ATPSAQVGKWEEDSESSSEESS---DSSDGEVPTAVAPAQEKSLGNILQA-----KPTS- 505

Query: 541 NKSFICGQNETPMETISLPPPIIQPMEVQMKVK-----TNASQVPAEPKERPLLSLIREK 595
                     +P +    PP    P+ VQ+K +     + +S+  ++  +          
Sbjct: 506 ----------SPAKG---PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 552

Query: 596 ARPRPTQKIPETKALKHKLSTT-SETVSQRTIGKKQPKKVEKNTSTDEFT------WPKP 648
           A+ +P  KIP+TKA   K +TT S  V+   +G + P+K    TS    +        +P
Sbjct: 553 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 612

Query: 649 NITSSTPKEKESVE-----------LHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKY 697
              SS+ +E +S E                +G     A  P      +   P+ P K   
Sbjct: 613 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK--- 669

Query: 698 RGPGKIVPKSREFIETDSSTSDSNTDQEE 726
              G  V + +   + DS +S+  +D EE
Sbjct: 670 --TGPTVTQVKAEKQEDSESSEEESDSEE 696



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 151/789 (19%), Positives = 259/789 (32%), Gaps = 156/789 (19%)

Query: 192 KLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSP-----------E 240
           K E+     A++ ++ +   ++ S++E+    +    A   +  +NS            E
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 241 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 300
           +++   +  G     +S+  P++G +V N   G   + S      T  V   + +   P 
Sbjct: 124 KAKAETEKAGK--TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181

Query: 301 ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI 360
                KP             G +  G+  ++S  T         +S      +    E+I
Sbjct: 182 FGAAAKP-------------GMVSAGQADSSSEDTS--------SSSDETDVEVKASEKI 220

Query: 361 LREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFK 420
           L+    S P   T               PG+ +    PG            + TK+   +
Sbjct: 221 LQVRAASAPAKGT---------------PGKGATPAPPG------KAGAVASQTKAGKPE 259

Query: 421 SMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPP----P 476
              E   + SSD ++  P      Q  A+     V  A           A P PP    P
Sbjct: 260 EDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGP 319

Query: 477 AV-QASGGSGSSSESESSSESDSDTESSTTDSESNEAPRV-ATPEPEPPSTNKWQLDKWL 534
           AV +A  G        SS ESDS+ E+      S +AP+V A   P   S  K       
Sbjct: 320 AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK------- 372

Query: 535 NKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIRE 594
                       G    P        P    ++V  + + + S       +R  L+ +  
Sbjct: 373 ------------GAAPAPPRKTG---PAAAQVQVGKQEEDSRSSSEESDSDREALAAM-N 416

Query: 595 KARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSST 654
            A+ +P  K P+ K      ST       +  G   P KV   T + +    + +  SS+
Sbjct: 417 AAQVKPLGKSPQVK----PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSS 472

Query: 655 PKEKESVELHDPPRGRNKATAHKPAPRK------EPRPNIPLAPEKKKYRGPGKIVPKSR 708
            +  +S +   P       TA  PA  K      + +P    A    +  GP  +  K+ 
Sbjct: 473 EESSDSSDGEVP-------TAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 525

Query: 709 EFIETDSSTSDS--NTDQEE------------TLQIKVLPPCIISGGNTAKSKEI----- 749
           + ++   S+ +S  + D EE             L+I     C      TA +K       
Sbjct: 526 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 585

Query: 750 CGASLTLSTLMSSSG----------------SNNNLSISNEEPTFSPIPVMQTEILSPLR 793
             A     T  S +G                S++  S S EE T   + V Q + +    
Sbjct: 586 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG--- 642

Query: 794 DHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKR 853
                K L VK     +    G  +    P K     T  K ++Q    + E+ +   + 
Sbjct: 643 -----KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 697

Query: 854 KHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTREN---NSSRRANRRKEE 910
              P +V   + + + +           P  + AP  K   +       ++ +A +R   
Sbjct: 698 AASPAQVKTSVKKTQAKAN---------PAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 748

Query: 911 KLFPPPLSP 919
           K+ PP  +P
Sbjct: 749 KVKPPVRNP 757



 Score = 38.5 bits (88), Expect = 0.043
 Identities = 77/355 (21%), Positives = 131/355 (36%), Gaps = 46/355 (12%)

Query: 200  PAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAP--GSPLVASS 257
            PA  P +G+   +  +A+  + P    ED+     +S+S EE+E   Q    G      +
Sbjct: 767  PASVPSVGKAVAT--AAQAQTGPE---EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRA 821

Query: 258  LLAPSSGLSVQNFPPGLYCKTSMG------QQKPTAYVRPMDGQDQAPDI---SPTLKPS 308
             LAP+     +   P    KT         Q    +     D   +AP     +  +KP 
Sbjct: 822  ALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPP 881

Query: 309  IEFENSFGNLSFGTLLDGKPSAASS--KTKLPKFTILQTSEVSLPSD----PSCVEEILR 362
            + F +   + +       +  AAS+  K +  + T   +S  S   D      C+   +R
Sbjct: 882  LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 941

Query: 363  EMTHSWPT------PLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKS 416
                + PT      P  SM  A  S+         ES  ++ G   +K   P T+ S K+
Sbjct: 942  TNVVTMPTAHPRIAPKASMAGASSSK---------ESSRISDG---KKQEGPATQVSKKN 989

Query: 417  VSFKSMLEDDLK-LSSDEDDLEPVKTLTTQCTATE-LYQAVEKAKPRNNPVNPP----LA 470
             +   + +  LK L+    + +P    T   +  +     +    P++  V       L 
Sbjct: 990  PASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLR 1049

Query: 471  TPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPST 525
             P+ P   QA+    SS +SE SS+S S +E      +  ++     P P    T
Sbjct: 1050 KPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTET 1104



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 157/802 (19%), Positives = 273/802 (34%), Gaps = 128/802 (15%)

Query: 201  AEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLA 260
            A Q Q+G+ EE + S+ E+S+ +     A       N+ +           P  AS++  
Sbjct: 386  AAQVQVGKQEEDSRSSSEESDSDREALAAM------NAAQVKPLGKSPQVKP--ASTMGM 437

Query: 261  PSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFG---N 317
               G      PPG      +G   P+A V   +   ++     +     E   +      
Sbjct: 438  GPLGKGAGPVPPG-----KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 492

Query: 318  LSFGTLLDGKPSAASSK----------TKLPKFTILQTSEVS-LPSDPSCVEEILREMTH 366
             S G +L  KP+++ +K           ++     +  SE S   SD +  EE    MT 
Sbjct: 493  KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 552

Query: 367  SWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTT--RASTKSVSFKSMLE 424
            +   P   +       + T +    +   +  G    +     T    S+ +V+  +   
Sbjct: 553  AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 612

Query: 425  DDLKLSSDEDDLEPVKT--LTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASG 482
             +   SS+E D E  KT    T   A  + + ++  K  + PV   L     P       
Sbjct: 613  AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ-VKAASVPVKGSLGQGTAP----VLP 667

Query: 483  GSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNK 542
            G    + ++  +E   D+ESS  +S+S EA   A+P     S  K          T    
Sbjct: 668  GKTGPTVTQVKAEKQEDSESSEEESDSEEA--AASPAQVKTSVKK----------TQAKA 715

Query: 543  SFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQ 602
            +    +  +   TIS P           KV T A+Q              R  ++ +P  
Sbjct: 716  NPAAARAPSAKGTISAPG----------KVVTAAAQAKQ-----------RSPSKVKPPV 754

Query: 603  KIPE--TKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 660
            + P+  T   +   S  S   +  T  + Q    E + S++E          S  +E+  
Sbjct: 755  RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE---------ESDSEEEAE 805

Query: 661  VELHDPPRGRNKATAHKPAPRKE-PRPNIPLAPEKKKYRGPGKIVPKSREFIETD---SS 716
                  P G+        AP KE PR      P       PGK  P + +  + D   SS
Sbjct: 806  TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-------PGKTGPSAAQAGKQDDSGSS 858

Query: 717  TSDSNTDQEETLQIK----VLPPCII------SGGNTAKSKEICGASLTLSTLMSSSGSN 766
            + +S++D E    +     + PP I         G  A   +   AS       S S + 
Sbjct: 859  SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 918

Query: 767  NNLSISNEE----PTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAA 822
            ++ S S +E     T    P ++T +++    H                R+   +S+  A
Sbjct: 919  SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAH---------------PRIAPKASMAGA 963

Query: 823  PAKPDHKETATKPKRQTAVTAVEK--PAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLL 880
             +  +    +   K++   T V K  PA     +     +A+K  E +  +        +
Sbjct: 964  SSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGV 1023

Query: 881  PPCISPAPPHKPPNT----RENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGP 936
               +   P   P +T    +  N  R+    + ++    P S   +D     + S  +  
Sbjct: 1024 DSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPES--SDDSEDSSDSSSGSEE 1081

Query: 937  FGQDKNIAMTGQITSTKPKRTE 958
             G+    A +       P RTE
Sbjct: 1082 DGEGPQGAKSAHTLGPTPSRTE 1103


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 79/329 (24%), Positives = 122/329 (37%), Gaps = 53/329 (16%)

Query: 424 EDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPL---ATPQPPPAVQA 480
           E+D + SS+E D +            +      + KP +     PL   A P PP  V  
Sbjct: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP 531

Query: 481 SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 540
           +  S    + E  SES S+  S   DS   E P    P  E    N  Q      K TS 
Sbjct: 532 ATPSAQVGKWEEDSESSSEESS---DSSDGEVPTAVAPAQEKSLGNILQA-----KPTS- 582

Query: 541 NKSFICGQNETPMETISLPPPIIQPMEVQMKVK-----TNASQVPAEPKERPLLSLIREK 595
                     +P +    PP    P+ VQ+K +     + +S+  ++  +          
Sbjct: 583 ----------SPAKG---PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 596 ARPRPTQKIPETKALKHKLSTT-SETVSQRTIGKKQPKKVEKNTSTDEFT------WPKP 648
           A+ +P  KIP+TKA   K +TT S  V+   +G + P+K    TS    +        +P
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689

Query: 649 NITSSTPKEKESVE-----------LHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKY 697
              SS+ +E +S E                +G     A  P      +   P+ P K   
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK--- 746

Query: 698 RGPGKIVPKSREFIETDSSTSDSNTDQEE 726
              G  V + +   + DS +S+  +D EE
Sbjct: 747 --TGPTVTQVKAEKQEDSESSEEESDSEE 773



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 156/826 (18%), Positives = 270/826 (32%), Gaps = 153/826 (18%)

Query: 192 KLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSP-----------E 240
           K E+     A++ ++ +   ++ S++E+    +    A   +  +NS            E
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 241 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 300
           +++   +  G     +S+  P++G +V N   G   + S      T  V   + +   P 
Sbjct: 124 KAKAETEKAGK--TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181

Query: 301 ISPTLKPSI-------EFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSD 353
                KP +              + S  T ++GKPS   ++ K    +  ++        
Sbjct: 182 FGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA 241

Query: 354 PSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQ---------- 403
           P  V ++  ++      P  +       E+S  S  G ES+   P  T            
Sbjct: 242 PGKVGDVTPQVKGGALPP--AKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299

Query: 404 -------------KWNDPT-------TRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLT 443
                        K   P          + TK+   +   E   + SSD ++  P     
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359

Query: 444 TQCTATELYQAVEKAKPRNNPVNPPLATPQPP----PAV-QASGGSGSSSESESSSESDS 498
            Q  A+     V  A           A P PP    PAV +A  G        SS ESDS
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419

Query: 499 DTESSTTDSESNEAPRV-ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETIS 557
           + E+      S +AP+V A   P   S  K                   G    P     
Sbjct: 420 EEEAPAQAKPSGKAPQVRAASAPAKESPRK-------------------GAAPAPPRKTG 460

Query: 558 LPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTT 617
              P    ++V  + + + S       +R  L+ +   A+ +P  K P+ K      ST 
Sbjct: 461 ---PAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVK----PASTM 512

Query: 618 SETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHK 677
                 +  G   P KV   T + +    + +  SS+ +  +S +   P       TA  
Sbjct: 513 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP-------TAVA 565

Query: 678 PAPRK------EPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS--NTDQEE--- 726
           PA  K      + +P    A    +  GP  +  K+ + ++   S+ +S  + D EE   
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA 625

Query: 727 ---------TLQIKVLPPCIISGGNTAKSKEI-----CGASLTLSTLMSSSG-------- 764
                     L+I     C      TA +K         A     T  S +G        
Sbjct: 626 AMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 685

Query: 765 --------SNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGH 816
                   S++  S S EE T   + V Q + +         K L VK     +    G 
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG--------KGLQVKAASVPVKGSLGQ 737

Query: 817 SSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATT 876
            +    P K     T  K ++Q    + E+ +   +    P +V   + + + +      
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN---- 793

Query: 877 ICLLPPCISPAPPHKPPNTREN---NSSRRANRRKEEKLFPPPLSP 919
                P  + AP  K   +       ++ +A +R   K+ PP  +P
Sbjct: 794 -----PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNP 834



 Score = 38.1 bits (87), Expect = 0.056
 Identities = 148/717 (20%), Positives = 244/717 (34%), Gaps = 109/717 (15%)

Query: 201  AEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLA 260
            A Q Q+G+ EE + S+ E+S+ +     A       N+ +           P  AS++  
Sbjct: 463  AAQVQVGKQEEDSRSSSEESDSDREALAAM------NAAQVKPLGKSPQVKP--ASTMGM 514

Query: 261  PSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFG---N 317
               G      PPG      +G   P+A V   +   ++     +     E   +      
Sbjct: 515  GPLGKGAGPVPPG-----KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569

Query: 318  LSFGTLLDGKPSAASSK----------TKLPKFTILQTSEVS-LPSDPSCVEEILREMTH 366
             S G +L  KP+++ +K           ++     +  SE S   SD +  EE    MT 
Sbjct: 570  KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 367  SWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTT--RASTKSVSFKSMLE 424
            +   P   +       + T +    +   +  G    +     T    S+ +V+  +   
Sbjct: 630  AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689

Query: 425  DDLKLSSDEDDLEPVKT--LTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASG 482
             +   SS+E D E  KT    T   A  + + ++  K  + PV   L     P       
Sbjct: 690  AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ-VKAASVPVKGSLGQGTAP----VLP 744

Query: 483  GSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNK 542
            G    + ++  +E   D+ESS  +S+S EA   A+P     S  K          T    
Sbjct: 745  GKTGPTVTQVKAEKQEDSESSEEESDSEEA--AASPAQVKTSVKK----------TQAKA 792

Query: 543  SFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQ 602
            +    +  +   TIS P           KV T A+Q              R  ++ +P  
Sbjct: 793  NPAAARAPSAKGTISAPG----------KVVTAAAQAKQ-----------RSPSKVKPPV 831

Query: 603  KIPE--TKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 660
            + P+  T   +   S  S   +  T  + Q    E + S++E          S  +E+  
Sbjct: 832  RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE---------ESDSEEEAE 882

Query: 661  VELHDPPRGRNKATAHKPAPRKE-PRPNIPLAPEKKKYRGPGKIVPKSREFIETD---SS 716
                  P G+        AP KE PR      P       PGK  P + +  + D   SS
Sbjct: 883  TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-------PGKTGPSAAQAGKQDDSGSS 935

Query: 717  TSDSNTDQEETLQIK----VLPPCII------SGGNTAKSKEICGASLTLSTLMSSSGSN 766
            + +S++D E    +     + PP I         G  A   +   AS       S S + 
Sbjct: 936  SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTAR 995

Query: 767  NNLSISNEE----PTFSPIPVMQTEILSPLRDHENL--KNLWVKIDLDLLSRVPGHSSLH 820
            ++ S S +E     T    P ++T +++    H  +  K           S         
Sbjct: 996  SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQ 1055

Query: 821  AAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEV--AEKIPEKKQRLEEAT 875
              PA        T P      T+V+       RK K  EV  A K PE     E+++
Sbjct: 1056 EGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1112



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 72/338 (21%), Positives = 120/338 (35%), Gaps = 50/338 (14%)

Query: 200  PAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAP--GSPLVASS 257
            PA  P +G+   +  +A+  + P    ED+     +S+S EE+E   Q    G      +
Sbjct: 844  PASVPSVGKAVAT--AAQAQTGPE---EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRA 898

Query: 258  LLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGN 317
             LAP+                   ++ P     P       P  +   K     ++  G+
Sbjct: 899  ALAPA-------------------KESPRKGAAPTPPGKTGPSAAQAGK-----QDDSGS 934

Query: 318  LSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHT 377
             S  +  DG+  AA +  ++ K  ++       P+ P+      +    S P    +  +
Sbjct: 935  SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPA--QAQAASTPRKARASES 992

Query: 378  AGHSEQSTFS----IPGQESQHLTPGFTLQKWNDPTTR---ASTKSVSFKSMLEDDLKLS 430
               S  S       IP   +Q LTPG        PT     A   S++  S  ++  ++S
Sbjct: 993  TARSSSSESEDEDVIPA--TQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRIS 1050

Query: 431  SDEDDLEP---VKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSS 487
              +    P   V +      AT       +AK  N      L  P+ P   QA+    SS
Sbjct: 1051 DGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNK-----LRKPKLPEVQQATKAPESS 1105

Query: 488  SESESSSESDSDTESSTTDSESNEAPRVATPEPEPPST 525
             +SE SS+S S +E      +  ++     P P    T
Sbjct: 1106 DDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTET 1143



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 159/744 (21%), Positives = 265/744 (35%), Gaps = 144/744 (19%)

Query: 198  VYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASS 257
            V PA++  +G + ++ P++     P         ++      + SE + ++  S   A S
Sbjct: 564  VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS---ADS 620

Query: 258  LLAPSSGLSVQNFPPGLYCKTSMGQQKP----TAYVRPMDGQDQAPDISPTLKPSIEFEN 313
              AP++  + Q  P     +T    +K     +A V P+    QAP  + T         
Sbjct: 621  EEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGT--------- 671

Query: 314  SFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLT 373
                    T   G   A +  T+ P       +E S  S+ S  EE   E T    T   
Sbjct: 672  -------ATSPAGSSPAVAGGTQRP-------AEDSSSSEESDSEE---EKTGLAVTVGQ 714

Query: 374  SMHTAGHSEQSTFSIP-----GQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLK 428
            +       +    S+P     GQ +  + PG T      PT          K+  ++D +
Sbjct: 715  AKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKT-----GPTV------TQVKAEKQEDSE 763

Query: 429  LSSDEDDLEP-------VKTLT--TQCTAT-----------------ELYQAVEKAKPRN 462
             S +E D E        VKT    TQ  A                  ++  A  +AK R+
Sbjct: 764  SSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRS 823

Query: 463  -NPVNPPLATPQP-------PPAVQASGGS-GSSSESESSSESDSDTESSTTDSESNEAP 513
             + V PP+  PQ        P +V + G +  +++++++  E DS +    +DSE  EA 
Sbjct: 824  PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE-EEAE 882

Query: 514  RVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVK 573
             +A  +P              +  T Q ++ +    E+P +  +  PP           K
Sbjct: 883  TLAQVKP--------------SGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928

Query: 574  TNASQVPAEPK----ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKK 629
             + S   +E      E P      +  +P P   +   ++     +T ++  +  T    
Sbjct: 929  QDDSGSSSEESDSDGEAPAAVTSAQVIKP-PLIFVDPNRSPAGPAATPAQAQAAST---- 983

Query: 630  QPKKVEKNTSTDEFTWPKPNITSSTPKEKESV----ELHDPPRGRNKATAHKPAPRKEPR 685
             P+K   + ST          +SS+  E E V    +   P    N  T     PR  P+
Sbjct: 984  -PRKARASESTAR--------SSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPK 1034

Query: 686  PNIPLA---------PEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPC 736
             ++  A          + KK  GP   V  +   + T  +TS  +T  +     K+  P 
Sbjct: 1035 ASMAGASSSKESSRISDGKKQEGPATQVDSA---VGTLPATSPQSTSVQAKGTNKLRKPK 1091

Query: 737  IISGGNTAKSKEICGASLTLSTLMSSSGSNNN---LSISNEEPTFSPIPVMQTEILSPLR 793
            +       K+ E    S   S   SSSGS  +      +    T  P P  +TE L    
Sbjct: 1092 LPEVQQATKAPESSDDSEDSSD--SSSGSEEDGEGPQGAKSAHTLGPTP-SRTETLVEET 1148

Query: 794  DHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAV--TAVEKPAPKG 851
              E+ ++  V     LLS   G+ +    PA     +   K     +V  T   K  P G
Sbjct: 1149 AAESSEDDVVAPSQSLLS---GYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDG 1205

Query: 852  KRKHKPIEVAEKIPEKKQRLEEAT 875
            K++ KP + A  +  K    E A+
Sbjct: 1206 KQEAKPQQAAGMLSPKTGGKEAAS 1229


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 79/329 (24%), Positives = 122/329 (37%), Gaps = 53/329 (16%)

Query: 424 EDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPL---ATPQPPPAVQA 480
           E+D + SS+E D +            +      + KP +     PL   A P PP  V  
Sbjct: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP 531

Query: 481 SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 540
           +  S    + E  SES S+  S   DS   E P    P  E    N  Q      K TS 
Sbjct: 532 ATPSAQVGKWEEDSESSSEESS---DSSDGEVPTAVAPAQEKSLGNILQA-----KPTS- 582

Query: 541 NKSFICGQNETPMETISLPPPIIQPMEVQMKVK-----TNASQVPAEPKERPLLSLIREK 595
                     +P +    PP    P+ VQ+K +     + +S+  ++  +          
Sbjct: 583 ----------SPAKG---PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629

Query: 596 ARPRPTQKIPETKALKHKLSTT-SETVSQRTIGKKQPKKVEKNTSTDEFT------WPKP 648
           A+ +P  KIP+TKA   K +TT S  V+   +G + P+K    TS    +        +P
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689

Query: 649 NITSSTPKEKESVE-----------LHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKY 697
              SS+ +E +S E                +G     A  P      +   P+ P K   
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK--- 746

Query: 698 RGPGKIVPKSREFIETDSSTSDSNTDQEE 726
              G  V + +   + DS +S+  +D EE
Sbjct: 747 --TGPTVTQVKAEKQEDSESSEEESDSEE 773



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 156/826 (18%), Positives = 270/826 (32%), Gaps = 153/826 (18%)

Query: 192 KLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSP-----------E 240
           K E+     A++ ++ +   ++ S++E+    +    A   +  +NS            E
Sbjct: 64  KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123

Query: 241 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 300
           +++   +  G     +S+  P++G +V N   G   + S      T  V   + +   P 
Sbjct: 124 KAKAETEKAGK--TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181

Query: 301 ISPTLKPSI-------EFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSD 353
                KP +              + S  T ++GKPS   ++ K    +  ++        
Sbjct: 182 FGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA 241

Query: 354 PSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQ---------- 403
           P  V ++  ++      P  +       E+S  S  G ES+   P  T            
Sbjct: 242 PGKVGDVTPQVKGGALPP--AKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299

Query: 404 -------------KWNDPT-------TRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLT 443
                        K   P          + TK+   +   E   + SSD ++  P     
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359

Query: 444 TQCTATELYQAVEKAKPRNNPVNPPLATPQPP----PAV-QASGGSGSSSESESSSESDS 498
            Q  A+     V  A           A P PP    PAV +A  G        SS ESDS
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419

Query: 499 DTESSTTDSESNEAPRV-ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETIS 557
           + E+      S +AP+V A   P   S  K                   G    P     
Sbjct: 420 EEEAPAQAKPSGKAPQVRAASAPAKESPRK-------------------GAAPAPPRKTG 460

Query: 558 LPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTT 617
              P    ++V  + + + S       +R  L+ +   A+ +P  K P+ K      ST 
Sbjct: 461 ---PAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVK----PASTM 512

Query: 618 SETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHK 677
                 +  G   P KV   T + +    + +  SS+ +  +S +   P       TA  
Sbjct: 513 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP-------TAVA 565

Query: 678 PAPRK------EPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS--NTDQEE--- 726
           PA  K      + +P    A    +  GP  +  K+ + ++   S+ +S  + D EE   
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA 625

Query: 727 ---------TLQIKVLPPCIISGGNTAKSKEI-----CGASLTLSTLMSSSG-------- 764
                     L+I     C      TA +K         A     T  S +G        
Sbjct: 626 AMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 685

Query: 765 --------SNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGH 816
                   S++  S S EE T   + V Q + +         K L VK     +    G 
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG--------KGLQVKAASVPVKGSLGQ 737

Query: 817 SSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATT 876
            +    P K     T  K ++Q    + E+ +   +    P +V   + + + +      
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN---- 793

Query: 877 ICLLPPCISPAPPHKPPNTREN---NSSRRANRRKEEKLFPPPLSP 919
                P  + AP  K   +       ++ +A +R   K+ PP  +P
Sbjct: 794 -----PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNP 834


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 102/435 (23%), Positives = 154/435 (35%), Gaps = 73/435 (16%)

Query: 456 EKAK-PRNNPVNPPLATPQPPPA---VQASGGSGSSSESESSSESDSDTE-------SST 504
           EKAK P       P     P  A   V+    S + ++S    E+ S  E        S 
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641

Query: 505 TDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQ 564
           T  E+    +  +PE E   +     +K  + V ++ KS    ++    E  S P     
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSP----EKAKSPVKAEAKSPEKAKSPVKAEAKS-PEKAKS 696

Query: 565 PMEVQMKVKTNASQVPAEPKERP--LLSLIREKARPRPTQKIPETKALKH----KLSTTS 618
           P++ + K    A     E  + P    S ++E+A+     K P  +  K     K    +
Sbjct: 697 PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA 756

Query: 619 ETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKP 678
           +T+  ++   K P K E  +  D+F    P    S  KE    E+  P + ++       
Sbjct: 757 KTLDVKSPEAKTPAKEEARSPADKF----PEKAKSPVKE----EVKSPEKAKSPLKEDAK 808

Query: 679 APRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCII 738
           AP KE        P+K++ + P K                    ++E+  ++KV  P   
Sbjct: 809 APEKE-------IPKKEEVKSPVK--------------------EEEKPQEVKVKEP--- 838

Query: 739 SGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENL 798
                 K  E   A  T  T      S    +   E P        +  +  P       
Sbjct: 839 -----PKKAEEEKAPATPKT-EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA 892

Query: 799 KNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPI 858
           K    K + +   +VP       APAK + KE A KPK +T V   E    K K   KP 
Sbjct: 893 K----KEEAEDKKKVPTPEK--EAPAKVEVKEDA-KPKEKTEVAKKEPDDAKAKEPSKPA 945

Query: 859 EVAEKIPEKKQRLEE 873
           E  E  PEKK   EE
Sbjct: 946 EKKEAAPEKKDTKEE 960



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 106/445 (23%), Positives = 165/445 (37%), Gaps = 48/445 (10%)

Query: 457 KAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVA 516
           K+ P     +P      P   V+    S + ++S    E+ S  E  + +   + A   A
Sbjct: 502 KSPPAEEAASPEKEAKSP---VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558

Query: 517 TPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNA 576
              PE  S  K +  K   +V S  K+          E    P     P + +  VK  A
Sbjct: 559 KSPPEAKSPEKEEA-KSPAEVKSPEKA-----KSPAKEEAKSPAEAKSPEKAKSPVKEEA 612

Query: 577 SQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEK 636
              PAE K     S ++E+A+     K PE    K K  T  E  S      K P+K E+
Sbjct: 613 KS-PAEAK-----SPVKEEAKSPAEVKSPE----KAKSPTKEEAKSPEKA--KSPEK-EE 659

Query: 637 NTSTDEFTWPKPNITSSTPKEKESV--ELHDPPRGRN--KATAHKPAPRKEPRPNIPLAP 692
             S ++   P      S  K K  V  E   P + ++  K  A  P   K P      +P
Sbjct: 660 AKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719

Query: 693 EKKK--YRGPGKIVPKSREFIETDSSTSDS--NTDQEETLQIKVLPPCIISGGNTAKSKE 748
           EK K   +   K   K++  ++ ++ + +   + ++ +TL +K  P         A+S  
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKS-PEAKTPAKEEARSPA 778

Query: 749 ICGASLTLSTLMSSSGSNNNLSISNEEPTFSP---IPVMQTEILSPLRDHENLKNLWVKI 805
                   S +     S        +E   +P   IP  + E+ SP+++ E  + + VK 
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE-EVKSPVKEEEKPQEVKVK- 836

Query: 806 DLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIP 865
                   P  +    APA P  +E     K +    A +K APK K + K     EK  
Sbjct: 837 ------EPPKKAEEEKAPATPKTEEKKDSKKEE----APKKEAPKPKVEEKKEPAVEKPK 886

Query: 866 EKK--QRLEEATTICLLPPCISPAP 888
           E K   + EEA     +P     AP
Sbjct: 887 ESKVEAKKEEAEDKKKVPTPEKEAP 911



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 53/236 (22%), Positives = 99/236 (41%), Gaps = 32/236 (13%)

Query: 420  KSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQ 479
            KS +++++K  S E    P+K         E  +A EK  P+   V  P+   + P  V+
Sbjct: 786  KSPVKEEVK--SPEKAKSPLK---------EDAKAPEKEIPKKEEVKSPVKEEEKPQEVK 834

Query: 480  ASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTS 539
                   + E ++ +   ++ +    DS+  EAP+   P+P+     +  ++K       
Sbjct: 835  VKEPPKKAEEEKAPATPKTEEKK---DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVE 891

Query: 540  QNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQ------------VPAEPKE-R 586
              K     + + P      P  +    + + K KT  ++             PAE KE  
Sbjct: 892  AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951

Query: 587  PLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDE 642
            P     +E+   +P +K P+T+A   K     +T+S+    K + +K EK++STD+
Sbjct: 952  PEKKDTKEEKAKKPEEK-PKTEA---KAKEDDKTLSKEP-SKPKAEKAEKSSSTDQ 1002



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 65/298 (21%), Positives = 118/298 (39%), Gaps = 25/298 (8%)

Query: 403 QKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAK-PR 461
           +K   P    +      KS ++++ K  ++    E  K+ T      E  ++ EKAK P 
Sbjct: 602 EKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK-----EEAKSPEKAKSPE 656

Query: 462 NNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPE 521
                 P     P   V+A   S   ++S   +E+ S  ++ +   E  ++P  A     
Sbjct: 657 KEEAKSPEKAKSP---VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK---S 710

Query: 522 PPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQ-MKVKTNASQVP 580
           P        +K  + V  + K+    ++    E  S P     P + + + VK+  ++ P
Sbjct: 711 PVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS-PEKAKSPEKAKTLDVKSPEAKTP 769

Query: 581 AEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTST 640
           A+ + R       EKA+    +++   +  K  L   ++        K+ PKK E  +  
Sbjct: 770 AKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE-----KEIPKKEEVKSPV 824

Query: 641 DEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHK-PAPRKE-PRPNIPLAPEKKK 696
            E   P+       PK+ E  +    P+   K  + K  AP+KE P+P +    E+KK
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV----EEKK 878



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 69/354 (19%), Positives = 129/354 (36%), Gaps = 48/354 (13%)

Query: 571 KVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQ 630
           + K+  ++  A P E+   S ++E+A+     K PE +  K                 K 
Sbjct: 500 ETKSPPAEEAASP-EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV------------KS 546

Query: 631 PKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPL 690
           P+K  K+ + +E   P    +    + K   E+  P + ++ A     +P +   P    
Sbjct: 547 PEKA-KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK 605

Query: 691 APEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEIC 750
           +P K++ + P +     +E  ++ +        +  T +    P         AKS E  
Sbjct: 606 SPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP-------EKAKSPEKE 658

Query: 751 GASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLL 810
            A        S   + + +    + P  +  PV + E  SP +    +K           
Sbjct: 659 EAK-------SPEKAKSPVKAEAKSPEKAKSPV-KAEAKSPEKAKSPVKE---------- 700

Query: 811 SRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQR 870
                  +     AK   KE A  P++  A + V++ A   ++   P++   K PEK + 
Sbjct: 701 ------EAKSPEKAKSPVKEEAKSPEK--AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKS 752

Query: 871 LEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPL-SPLPED 923
            E+A T+ +  P        +  +  +    +  +  KEE   P    SPL ED
Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKED 806



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 36/161 (22%), Positives = 57/161 (35%), Gaps = 5/161 (3%)

Query: 822 APAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLP 881
           +PA+    E A  P ++ A +  E  +P+ +    P EV      K    EEA +     
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA--- 596

Query: 882 PCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPL-SPLPEDPPRRRNVSGNNGPFGQD 940
              SP     P      + +   +  KEE   P  + SP     P +            +
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE 656

Query: 941 KNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASS 981
           K  A + +  +  P + E K     K     E  +P+KA S
Sbjct: 657 KEEAKSPE-KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKS 696


>gi|239740955 PREDICTED: similar to c114 SLIT-like testicular
           protein isoform 1 [Homo sapiens]
          Length = 1635

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 132/597 (22%), Positives = 217/597 (36%), Gaps = 81/597 (13%)

Query: 200 PAEQPQIG------EVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPL 253
           P    Q+G      E E  NP   ED   +S  ++A  ++ Q    E S    +AP  P 
Sbjct: 207 PGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPP 266

Query: 254 VAS--SLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEF 311
            +S  SL  P+  +SVQ  PPG   +       P   V+P D      +++ T +P+ E 
Sbjct: 267 ESSMESLTLPNHEVSVQ--PPG---EDQAYYHLPNITVKPAD-----VEVTITSEPTNET 316

Query: 312 ENSFGNLSFGTLL--DGKPSAASSKTKL-----PKFTILQTSEVSLPSDPSCVEEILREM 364
           E+S            + +PSA   +  +     P    L  SE   P  PS   E  RE+
Sbjct: 317 ESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPS---ESPREV 373

Query: 365 THSWPTPLTSMHTAGHSEQSTFSIPGQESQH--LTPGFTLQKWNDPTTRASTKSVSFKSM 422
             S PT   +        + T S PG    H   +P  +++  +   T A+  S    + 
Sbjct: 374 ESS-PTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTS 432

Query: 423 L---EDDLKLSSDEDDLEPV------KTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQ 473
           L   E   +LS   +D+EP         L  + +      AV++     +P   P+    
Sbjct: 433 LVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSP--EPINNEN 490

Query: 474 PPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKW 533
           P P  Q      ++   +++ E +S        +++ E P V   +P   S       + 
Sbjct: 491 PSPTQQ----EAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQP 546

Query: 534 LN---KVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTN------ASQVPAEPK 584
           L+    +T ++K+ +   + T  ET + PP  + P     +  TN       +Q P  P 
Sbjct: 547 LDLGFTITPESKTEV-ELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPS 605

Query: 585 ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFT 644
               L  +     P PT ++  +   K  +   S    + T+      + + +  T    
Sbjct: 606 VTVQLLDLGLTITPEPTTEVGHSTPPKRTI--VSPKHPEVTLPHPDQVQTQHSHLTRATV 663

Query: 645 WPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKK-----KYRG 699
            P     + TPK    VE    P      TA  P       P + L P  K      +  
Sbjct: 664 QPLDLGFTITPKSMTEVE----PSTALMTTAPPPG-----HPEVTLPPSDKGQAQHSHLT 714

Query: 700 PGKIVPKSREFIET--------DSSTSDSNTDQEETLQIKVLP-PCIISGGNTAKSK 747
              + P   E   T         S T++  + Q   L + ++P P   +G +TA  K
Sbjct: 715 QATVQPLDLELTITTKPTTEVKPSPTTEETSTQPPDLGLAIIPEPTTETGHSTALEK 771


>gi|239740953 PREDICTED: similar to c114 SLIT-like testicular
           protein isoform 2 [Homo sapiens]
          Length = 1700

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 132/597 (22%), Positives = 217/597 (36%), Gaps = 81/597 (13%)

Query: 200 PAEQPQIG------EVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPL 253
           P    Q+G      E E  NP   ED   +S  ++A  ++ Q    E S    +AP  P 
Sbjct: 207 PGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPP 266

Query: 254 VAS--SLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEF 311
            +S  SL  P+  +SVQ  PPG   +       P   V+P D      +++ T +P+ E 
Sbjct: 267 ESSMESLTLPNHEVSVQ--PPG---EDQAYYHLPNITVKPAD-----VEVTITSEPTNET 316

Query: 312 ENSFGNLSFGTLL--DGKPSAASSKTKL-----PKFTILQTSEVSLPSDPSCVEEILREM 364
           E+S            + +PSA   +  +     P    L  SE   P  PS   E  RE+
Sbjct: 317 ESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPS---ESPREV 373

Query: 365 THSWPTPLTSMHTAGHSEQSTFSIPGQESQH--LTPGFTLQKWNDPTTRASTKSVSFKSM 422
             S PT   +        + T S PG    H   +P  +++  +   T A+  S    + 
Sbjct: 374 ESS-PTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTS 432

Query: 423 L---EDDLKLSSDEDDLEPV------KTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQ 473
           L   E   +LS   +D+EP         L  + +      AV++     +P   P+    
Sbjct: 433 LVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSP--EPINNEN 490

Query: 474 PPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKW 533
           P P  Q      ++   +++ E +S        +++ E P V   +P   S       + 
Sbjct: 491 PSPTQQ----EAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQP 546

Query: 534 LN---KVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTN------ASQVPAEPK 584
           L+    +T ++K+ +   + T  ET + PP  + P     +  TN       +Q P  P 
Sbjct: 547 LDLGFTITPESKTEV-ELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPS 605

Query: 585 ERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFT 644
               L  +     P PT ++  +   K  +   S    + T+      + + +  T    
Sbjct: 606 VTVQLLDLGLTITPEPTTEVGHSTPPKRTI--VSPKHPEVTLPHPDQVQTQHSHLTRATV 663

Query: 645 WPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKK-----KYRG 699
            P     + TPK    VE    P      TA  P       P + L P  K      +  
Sbjct: 664 QPLDLGFTITPKSMTEVE----PSTALMTTAPPPG-----HPEVTLPPSDKGQAQHSHLT 714

Query: 700 PGKIVPKSREFIET--------DSSTSDSNTDQEETLQIKVLP-PCIISGGNTAKSK 747
              + P   E   T         S T++  + Q   L + ++P P   +G +TA  K
Sbjct: 715 QATVQPLDLELTITTKPTTEVKPSPTTEETSTQPPDLGLAIIPEPTTETGHSTALEK 771


>gi|151301154 mucin 6, gastric [Homo sapiens]
          Length = 2439

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 185/973 (19%), Positives = 310/973 (31%), Gaps = 131/973 (13%)

Query: 125  PHQDNTHPSAPMPPPSVVILNSTLIHSN----RKSKPEWSRDSHNP--STVLASQASG-- 176
            PH  ++ P+A  P PS   + +T  H+       S PE +  +H P  ST L + ++   
Sbjct: 1403 PHTTHSPPTAGSPVPSTGPVTATSFHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTV 1462

Query: 177  -QPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQ 235
              P   Q  T   + +        P      G    + P       P +SG       F 
Sbjct: 1463 ITPTHAQMATSASNHSAPTGTIPPPTTLKATGSTHTAPP-----ITPTTSGTSQAHSSFS 1517

Query: 236  SN-SPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDG 294
            +N +P        +   P V      P+S  ++   P      TS   + P A+      
Sbjct: 1518 TNKTPTSLHSHTSSTHHPEV-----TPTSTTTITPNP------TSTRTRTPVAHTNSATS 1566

Query: 295  QDQAPDIS----PTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSL 350
                P  +    PT              SF T     P+ +  +T LP      ++ +  
Sbjct: 1567 SRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTT-YPTPSHPQTTLPTHVPPFSTSLVT 1625

Query: 351  PSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTT 410
            PS  + +     +M  S    + SM T      +T    G  S H  P  TL      TT
Sbjct: 1626 PSTHTVITPTHAQMATS--ASIHSMPTGTIPPPTTLKATG--STHTAPTMTL------TT 1675

Query: 411  RASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNP-PL 469
              +++++S                 L   KT T+  + T      E        + P P 
Sbjct: 1676 SGTSQALS----------------SLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPT 1719

Query: 470  ATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQ 529
            +T  PP  V  SG S S S S S++++ +   S T+ +   E    +T    P  T+   
Sbjct: 1720 STGTPPMTVTTSGTSQSRS-SFSTAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTS--- 1775

Query: 530  LDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLL 589
                     +   S    +  TP  T S PP    P+                    P+ 
Sbjct: 1776 --TGTRTPVAHTTSATSSRLPTPFTTHS-PPTGTTPIS----------------STGPVT 1816

Query: 590  SLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPN 649
            +   +     PT   P T    H  S ++  V+  T     P   +  TS    + P   
Sbjct: 1817 ATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMPTGT 1876

Query: 650  I-TSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSR 708
            I   +T K   S     P       T+  P+     + +  L         P ++ P S 
Sbjct: 1877 IPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHP-EVTPTST 1935

Query: 709  EFIETDSSTSDSNTDQEETLQI---KVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGS 765
              I    +++ + T    T      ++  P       T  S       +T ++  +++  
Sbjct: 1936 TNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSSTGPMTATSFQTTTTY 1995

Query: 766  NNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAK 825
                      PT   +P   T +++P             + +   +++   +S+H+ P  
Sbjct: 1996 PTPSHPQTTLPTH--VPPFSTSLVTPSTH---------TVIITTHTQMATSASIHSTPT- 2043

Query: 826  PDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCIS 885
                 T   P    A  +     P         +               ++   LP   S
Sbjct: 2044 ----GTVPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSS 2099

Query: 886  PAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNV--SGNNGPFGQDKNI 943
              PP  P  T+  + S                SP P  P    +   S ++ P     ++
Sbjct: 2100 SRPPSSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSV 2159

Query: 944  AMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVT 1003
              +    S           A     +++ G     +S +T   T +  A+    ++   +
Sbjct: 2160 GTSSSFVS-----------APVHSTTLSSG---SHSSLSTHPTTASVSASPLFPSSPAAS 2205

Query: 1004 TTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWA------------ALPLL 1051
            TT+ AT   T ++  T + +  I ST+T     SSHL  ++ A              P  
Sbjct: 2206 TTIRATLPHTISSPFTLSALLPI-STVTVSPTPSSHLASSTIAFPSTPRTTASTHTAPAF 2264

Query: 1052 SSSSTNVRRPKLT 1064
            SS ST  R   LT
Sbjct: 2265 SSQSTTSRSTSLT 2277



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 119/616 (19%), Positives = 194/616 (31%), Gaps = 58/616 (9%)

Query: 468  PLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNK 527
            P   P  P +V  S   G  + S+   E     E           P+  T  P+ P+T  
Sbjct: 1159 PCLCPSQPQSVPGSNIEGCYNCSQD--EYFDHEEGVCVPCMPPTTPQPPTT-PQLPTTGS 1215

Query: 528  WQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERP 587
                 W    TS     +     +P    +   P   P+       +  +    EP  RP
Sbjct: 1216 RPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASPTQTPLLPATLTSSKPTASSGEPP-RP 1274

Query: 588  LLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDE----- 642
              ++      P+ T  +P T  L+   + T  TV+Q T            TST +     
Sbjct: 1275 TTAVT-----PQATSGLPPTATLRS--TATKPTVTQATTRATASTASPATTSTAQSTTRT 1327

Query: 643  -FTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPG 701
              T P P  + ++P   +S     P     + T  +P P     P  P   +  +     
Sbjct: 1328 TMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPGQPTR----- 1382

Query: 702  KIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMS 761
               P + E  +T ++T  +      T      PP   + G+   S     A+   +T   
Sbjct: 1383 ---PTATETTQTRTTTEYTTPQTPHTTHS---PP---TAGSPVPSTGPVTATSFHATTTY 1433

Query: 762  SSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHA 821
             + S+   ++    P FS      T +++P             +     +++   +S H+
Sbjct: 1434 PTPSHPETTLPTHVPPFS------TSLVTPSTH---------TVITPTHAQMATSASNHS 1478

Query: 822  APAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLP 881
            AP       T  K    T       P   G  +        K P        +T    + 
Sbjct: 1479 APTGTIPPPTTLKATGSTHTAPPITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVT 1538

Query: 882  PCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDK 941
            P  +      P +TR        N     +  PPP +     PP   +   + GP     
Sbjct: 1539 PTSTTTITPNPTSTRTRTPVAHTNSATSSRP-PPPFTT--HSPPTGSSPFSSTGPMTATS 1595

Query: 942  NIAMTGQITSTKPKRTEGKFCATFKGISVNEGD----TPKKASSATITV-----TNTAIA 992
                T   T + P+ T       F    V        TP  A  AT        T T   
Sbjct: 1596 FKTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPP 1655

Query: 993  TATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLS 1052
              T+ AT    T  T T T + T+   ++  +  TST       S+H    +  +   ++
Sbjct: 1656 PTTLKATGSTHTAPTMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNIT 1715

Query: 1053 SSSTNVRRPKLTFDDS 1068
             + T+   P +T   S
Sbjct: 1716 PNPTSTGTPPMTVTTS 1731



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 168/794 (21%), Positives = 258/794 (32%), Gaps = 112/794 (14%)

Query: 328  PSAASSKTKLPKFTILQTS-----EVSLPSDPSCVEEILREMTHSWPTPLT-----SMHT 377
            P   +++T  P+ T   T+     +   P+ P+  E      T  + TP T     S  T
Sbjct: 1352 PGTTATQTTGPRPTPASTTGPTTPQPGQPTRPTATETTQTRTTTEYTTPQTPHTTHSPPT 1411

Query: 378  AGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLE 437
            AG    ST  +    S H T  +     + P T   T    F +     L   S    + 
Sbjct: 1412 AGSPVPSTGPVTAT-SFHATTTYPTP--SHPETTLPTHVPPFST----SLVTPSTHTVIT 1464

Query: 438  PVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESD 497
            P  T     T+   + A     P    +    +T   PP    + G+  +  S S++++ 
Sbjct: 1465 P--THAQMATSASNHSAPTGTIPPPTTLKATGSTHTAPPITPTTSGTSQAHSSFSTNKTP 1522

Query: 498  SDTESSTTDSESNEAPRVATPE--PEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMET 555
            +   S T+ +   E    +T    P P ST         N  TS         +  P  T
Sbjct: 1523 TSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVAHTNSATSSRPPPPFTTHSPP--T 1580

Query: 556  ISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKI-PETKAL---K 611
             S P     PM       T     P+ P+     + +     P  T  + P T  +    
Sbjct: 1581 GSSPFSSTGPMTATSFKTTTTYPTPSHPQ-----TTLPTHVPPFSTSLVTPSTHTVITPT 1635

Query: 612  HKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKE--------KESVEL 663
            H    TS ++     G   P    K T +   T P   +T+S   +        K S  L
Sbjct: 1636 HAQMATSASIHSMPTGTIPPPTTLKATGSTH-TAPTMTLTTSGTSQALSSLNTAKTSTSL 1694

Query: 664  HDPPRGRNKATAHK-------PAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSS 716
            H      + A A         P P     P + +               K+   + + +S
Sbjct: 1695 HSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSFSTAKTSTSLHSHTS 1754

Query: 717  TSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSS-SGSNNNLSISNEE 775
             S  + +   T    + P    +G  T  +      S  L T  ++ S       IS+  
Sbjct: 1755 -STHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTHSPPTGTTPISSTG 1813

Query: 776  PTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAK-----PDHKE 830
            P  +      T   +P   H  L            + VP  S+    P+      P H +
Sbjct: 1814 PVTATSFQTTTTYPTPSHPHTTLP-----------THVPSFSTSLVTPSTHTVIIPTHTQ 1862

Query: 831  TATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIP------EKKQRLEEATTICLLP--- 881
             AT     +  T    P    K            P      +       A T   LP   
Sbjct: 1863 MATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHT 1922

Query: 882  -----PCISPA------PPHKPPNTRE---NNSSRRANRRKEEKLFPPPLSPLPEDPPRR 927
                 P ++P       P H    TR    + +S  ++R       P P +     PP  
Sbjct: 1923 SSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSASSSR------LPTPFTT--HSPPTG 1974

Query: 928  RNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVT 987
             +   + GP         T   T + P+ T       F    V    TP  ++   I  T
Sbjct: 1975 SSPFSSTGPMTATSFQTTTTYPTPSHPQTTLPTHVPPFSTSLV----TP--STHTVIITT 2028

Query: 988  NTAIATA-----TVTATAIVTTTVTAT-ATATATTTTTTTTISTIT-STITTGLMDSSHL 1040
            +T +AT+     T T T    TT+ AT +T TA   T TT+ ++ T S+ +T    SS +
Sbjct: 2029 HTQMATSASIHSTPTGTVPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFI 2088

Query: 1041 EMTSWAALPLLSSS 1054
              +SW  LP  SSS
Sbjct: 2089 SSSSW--LPQNSSS 2100



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 162/833 (19%), Positives = 256/833 (30%), Gaps = 112/833 (13%)

Query: 249  PGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPS 308
            P +P   ++   P++G       P     T++G    T    P    +  P  SPT  P 
Sbjct: 1199 PTTPQPPTTPQLPTTGSRPTQVWPMTGTSTTIGLLSSTG---PSPSSNHTP-ASPTQTPL 1254

Query: 309  IEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSC--------VEEI 360
            +            TL   KP+A+S +   P   +   +   LP   +         V + 
Sbjct: 1255 LP----------ATLTSSKPTASSGEPPRPTTAVTPQATSGLPPTATLRSTATKPTVTQA 1304

Query: 361  LREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDP----TTRASTKS 416
                T S  +P T+  TA  + ++T ++P   +   +P  TL K  +     TT   T  
Sbjct: 1305 TTRATASTASPATTS-TAQSTTRTTMTLPTPATSGTSP--TLPKSTNQELPGTTATQTTG 1361

Query: 417  VSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPP 476
                                 P  T TTQ   T  Y                  TPQ P 
Sbjct: 1362 PRPTPASTTGPTTPQPGQPTRPTATETTQTRTTTEY-----------------TTPQTPH 1404

Query: 477  AVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNK 536
               +   +GS   S     + S   ++T  + S+  P    P   PP +           
Sbjct: 1405 TTHSPPTAGSPVPSTGPVTATSFHATTTYPTPSH--PETTLPTHVPPFSTSLVTPSTHTV 1462

Query: 537  VTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKA 596
            +T  +       +     T ++PPP          +K   S   A P   P  S   +  
Sbjct: 1463 ITPTHAQMATSASNHSAPTGTIPPPTT--------LKATGSTHTAPPIT-PTTSGTSQAH 1513

Query: 597  RPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTP- 655
                T K P T    H  ST    V+  +     P      T T     P  +  S+T  
Sbjct: 1514 SSFSTNKTP-TSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRT-----PVAHTNSATSS 1567

Query: 656  KEKESVELHDPPRGRN-------------KATAHKPAPRKEPRPNIP--LAPEKKKYRGP 700
            +       H PP G +             K T   P P   P+  +P  + P       P
Sbjct: 1568 RPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTP-SHPQTTLPTHVPPFSTSLVTP 1626

Query: 701  GK---IVPKSREFIETDS------STSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICG 751
                 I P   +   + S       T    T  + T      P   ++   T+++     
Sbjct: 1627 STHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTTSGTSQALSSLN 1686

Query: 752  ASLTLSTLMSSSGSNNNLSISNEE-------PTFSPIPVMQTEILSPLRDHENLKNLWVK 804
             + T ++L S + S ++   ++         PT +  P M        +   +       
Sbjct: 1687 TAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSFSTAKTS 1746

Query: 805  IDLDLLSRVPGH---SSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVA 861
              L   +    H   +S       P+H  T T+       +A     P     H P    
Sbjct: 1747 TSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTHSP--PT 1804

Query: 862  EKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLP 921
               P        AT+        +P+ PH    T   + S          +  P  + + 
Sbjct: 1805 GTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMA 1864

Query: 922  EDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGD--TPKKA 979
                     +G   P      I  TG  T T P  T      T  G S +     T K +
Sbjct: 1865 TSASIHSMPTGTIPP---PTTIKATGS-THTAPPMTP-----TTSGTSQSPSSFSTAKTS 1915

Query: 980  SSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITT 1032
            +S     ++T     T T+T  +T   T+T T T    TT+ + S + +  TT
Sbjct: 1916 TSLPYHTSSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTT 1968


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,099,714
Number of Sequences: 37866
Number of extensions: 3082036
Number of successful extensions: 31261
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 177
Number of HSP's successfully gapped in prelim test: 639
Number of HSP's that attempted gapping in prelim test: 17313
Number of HSP's gapped (non-prelim): 7149
length of query: 1311
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1197
effective length of database: 13,930,794
effective search space: 16675160418
effective search space used: 16675160418
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.