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Search of human proteins with 7662240
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens]
(536 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] 1107 0.0
gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] 1107 0.0
gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] 434 e-122
gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] 434 e-122
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 102 9e-22
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 76 7e-14
gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] 75 2e-13
gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 68 2e-11
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 68 2e-11
gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] 54 5e-07
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 49 1e-05
gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] 46 7e-05
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 44 3e-04
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 44 3e-04
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 42 0.001
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 42 0.001
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 42 0.001
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 42 0.001
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 40 0.004
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 40 0.004
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 40 0.004
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 39 0.009
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 39 0.009
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 37 0.059
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 37 0.059
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 37 0.059
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 37 0.059
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 35 0.13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 35 0.17
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 35 0.17
>gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 1107 bits (2862), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR 60
MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR
Sbjct: 1 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR 60
Query: 61 ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW 120
ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW
Sbjct: 61 ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW 120
Query: 121 GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR 180
GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR
Sbjct: 121 GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR 180
Query: 181 LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV 240
LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV
Sbjct: 181 LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV 240
Query: 241 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG 300
SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG
Sbjct: 241 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG 300
Query: 301 PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH 360
PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH
Sbjct: 301 PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH 360
Query: 361 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR 420
TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR
Sbjct: 361 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR 420
Query: 421 RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF 480
RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF
Sbjct: 421 RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF 480
Query: 481 PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK 536
PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
Sbjct: 481 PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK 536
>gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 1107 bits (2862), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR 60
MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR
Sbjct: 1 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR 60
Query: 61 ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW 120
ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW
Sbjct: 61 ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW 120
Query: 121 GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR 180
GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR
Sbjct: 121 GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR 180
Query: 181 LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV 240
LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV
Sbjct: 181 LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV 240
Query: 241 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG 300
SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG
Sbjct: 241 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG 300
Query: 301 PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH 360
PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH
Sbjct: 301 PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH 360
Query: 361 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR 420
TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR
Sbjct: 361 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR 420
Query: 421 RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF 480
RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF
Sbjct: 421 RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF 480
Query: 481 PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK 536
PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
Sbjct: 481 PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK 536
>gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 434 bits (1117), Expect = e-122
Identities = 234/436 (53%), Positives = 295/436 (67%), Gaps = 15/436 (3%)
Query: 93 SIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFG--RTRSGLQ 150
+I K+ D V P T +R W GKK S S K++S DA+ G +T L+
Sbjct: 7 NISKNVD--VRPKTSRSRSADRKDGYVWSGKKL-SWSKKSESYSDAETVNGIEKTEVSLR 63
Query: 151 RRERRYGVSSVH-DMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIH 209
+ER++ SS+ D+D RSL+Q+LQD VG CFP++ S + +KRKIH
Sbjct: 64 NQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKRKIH 123
Query: 210 LSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRR 269
+SELML+KCPFP SDLA +WH IK+HTAP++ S + + D L TE + +L+ R
Sbjct: 124 ISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTD--LSQTELRDGQLKRR-- 179
Query: 270 LSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTT 329
++EE ++ + + T N L + GP M +S +S I ++ DS+++
Sbjct: 180 -NMEENINCFSHTNVQPCVITTD-NALCREGPMTGSVMNLVSNNS--IEDSDMDSDDEIL 235
Query: 330 TLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRY 389
TLC SR++ + + D + + K HTQIDY+HCLVPDLLQI NPCYWGVMD+Y
Sbjct: 236 TLCTSSRKRNKPKWDLDDEI-LQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKY 294
Query: 390 EAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHS 449
AEALLEGKPEGTFLLRDSAQEDYLFSVSFRRY+RSLHARIEQWNHNFSFDAHDPCVFHS
Sbjct: 295 AAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHS 354
Query: 450 STVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSM 509
+TGLLEHYKDPS+CMFFEPLL+ L RTFPFSLQ+ICR VIC CTTYDGID LP+PS
Sbjct: 355 PDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSS 414
Query: 510 LQDFLKEYHYKQKVRV 525
++ +LKEYHYK KVRV
Sbjct: 415 MKLYLKEYHYKSKVRV 430
>gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 434 bits (1117), Expect = e-122
Identities = 234/436 (53%), Positives = 295/436 (67%), Gaps = 15/436 (3%)
Query: 93 SIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFG--RTRSGLQ 150
+I K+ D V P T +R W GKK S S K++S DA+ G +T L+
Sbjct: 7 NISKNVD--VRPKTSRSRSADRKDGYVWSGKKL-SWSKKSESYSDAETVNGIEKTEVSLR 63
Query: 151 RRERRYGVSSVH-DMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIH 209
+ER++ SS+ D+D RSL+Q+LQD VG CFP++ S + +KRKIH
Sbjct: 64 NQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKRKIH 123
Query: 210 LSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRR 269
+SELML+KCPFP SDLA +WH IK+HTAP++ S + + D L TE + +L+ R
Sbjct: 124 ISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTD--LSQTELRDGQLKRR-- 179
Query: 270 LSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTT 329
++EE ++ + + T N L + GP M +S +S I ++ DS+++
Sbjct: 180 -NMEENINCFSHTNVQPCVITTD-NALCREGPMTGSVMNLVSNNS--IEDSDMDSDDEIL 235
Query: 330 TLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRY 389
TLC SR++ + + D + + K HTQIDY+HCLVPDLLQI NPCYWGVMD+Y
Sbjct: 236 TLCTSSRKRNKPKWDLDDEI-LQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKY 294
Query: 390 EAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHS 449
AEALLEGKPEGTFLLRDSAQEDYLFSVSFRRY+RSLHARIEQWNHNFSFDAHDPCVFHS
Sbjct: 295 AAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHS 354
Query: 450 STVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSM 509
+TGLLEHYKDPS+CMFFEPLL+ L RTFPFSLQ+ICR VIC CTTYDGID LP+PS
Sbjct: 355 PDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSS 414
Query: 510 LQDFLKEYHYKQKVRV 525
++ +LKEYHYK KVRV
Sbjct: 415 MKLYLKEYHYKSKVRV 430
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 102 bits (254), Expect = 9e-22
Identities = 61/165 (36%), Positives = 91/165 (55%), Gaps = 15/165 (9%)
Query: 369 LVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHA 428
L +L ++ YWG + R+EAE L P+G+FL+RDS+ + YL S+SFR + ++LH
Sbjct: 372 LTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHT 431
Query: 429 RIEQWNHNFSFDAHDPCVFHSSTVTGLLEH-YKDPSSCMFFEPLLTISLNRTFPF----- 482
RIE N FSF P V +++ L+EH +D + F + + T+P
Sbjct: 432 RIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNP 490
Query: 483 --------SLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHY 519
SLQY+CR VI + T D I LPLP+ ++D+L+E HY
Sbjct: 491 VSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 76.3 bits (186), Expect = 7e-14
Identities = 55/152 (36%), Positives = 80/152 (52%), Gaps = 16/152 (10%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
YWG M EA+ L+ PEGTFL+RDS+ DYL ++S + + RIE + F D+
Sbjct: 49 YWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDS 108
Query: 442 HDPCVFHS----STVTGLLEHY----KDPSSCMFFEPLLTISLNRTFPF-----SLQYIC 488
CV +V L+++Y KD + T+ L T P SLQ++C
Sbjct: 109 -IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLC 167
Query: 489 RAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520
R I +CT I GLPLP+ L+D+L+EY ++
Sbjct: 168 RLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197
>gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens]
Length = 581
Score = 75.1 bits (183), Expect = 2e-13
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 15/153 (9%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
YWG M+ +AE L+GKP+G+FL+RDS+ Y+ S+SFR + H R+E + FS
Sbjct: 401 YWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWC 460
Query: 442 H----DPCVFHSSTVTGLLEHYKDPSSCMFFEP----LLTISLNRTFPF-------SLQY 486
H D C + + H K+ F L + +P SLQ+
Sbjct: 461 HPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQH 520
Query: 487 ICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHY 519
+CR I + D I LPLP L ++++++Y
Sbjct: 521 LCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYY 553
>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
[Homo sapiens]
Length = 275
Score = 68.2 bits (165), Expect = 2e-11
Identities = 52/191 (27%), Positives = 80/191 (41%), Gaps = 40/191 (20%)
Query: 368 CLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLH 427
C+ + + YWG + EA L+ PEGTFL+RDS YLF++S + +
Sbjct: 86 CIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTN 145
Query: 428 ARIEQWNHNFSFDAH---DPCVFHSSTVTGLLEHY------------KDPSSCMFF---- 468
RIE + +F D++ P + V L++HY DP+
Sbjct: 146 VRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPK 205
Query: 469 ------------EPLLTISLNRTFPF-------SLQYICRAVICRCTTYDGIDGLPLPSM 509
P + L PF SLQ++CR VI R +D LPLP
Sbjct: 206 EDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVA--DVDCLPLPRR 263
Query: 510 LQDFLKEYHYK 520
+ D+L++Y ++
Sbjct: 264 MADYLRQYPFQ 274
>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
Length = 258
Score = 68.2 bits (165), Expect = 2e-11
Identities = 52/191 (27%), Positives = 80/191 (41%), Gaps = 40/191 (20%)
Query: 368 CLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLH 427
C+ + + YWG + EA L+ PEGTFL+RDS YLF++S + +
Sbjct: 69 CIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTN 128
Query: 428 ARIEQWNHNFSFDAH---DPCVFHSSTVTGLLEHY------------KDPSSCMFF---- 468
RIE + +F D++ P + V L++HY DP+
Sbjct: 129 VRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPK 188
Query: 469 ------------EPLLTISLNRTFPF-------SLQYICRAVICRCTTYDGIDGLPLPSM 509
P + L PF SLQ++CR VI R +D LPLP
Sbjct: 189 EDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVA--DVDCLPLPRR 246
Query: 510 LQDFLKEYHYK 520
+ D+L++Y ++
Sbjct: 247 MADYLRQYPFQ 257
>gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
Length = 211
Score = 53.5 bits (127), Expect = 5e-07
Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 14/142 (9%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
YWG + + A L +P GTFL+RDS Q + F++S + + R+ F D
Sbjct: 80 YWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG 139
Query: 442 HD---PCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTY 498
C+F LLEHY M PL R P LQ +CR I
Sbjct: 140 SRESFDCLFE------LLEHYVAAPRRMLGAPL---RQRRVRP--LQELCRQRIVATVGR 188
Query: 499 DGIDGLPLPSMLQDFLKEYHYK 520
+ + +PL +L+D+L + ++
Sbjct: 189 ENLARIPLNPVLRDYLSSFPFQ 210
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 48.9 bits (115), Expect = 1e-05
Identities = 36/101 (35%), Positives = 51/101 (50%), Gaps = 10/101 (9%)
Query: 362 QIDYIHCLVPDLL-QITGNPCYWGVMDRYEAE-ALLEGKPEGTFLLRDSAQEDYLFSVSF 419
Q DYI P L + GNP Y+G + R++AE AL E EG FL+RDS FSVS
Sbjct: 265 QCDYIR---PSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSL 321
Query: 420 RRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYK 460
+ ++ H +++ + ST+ L+EHYK
Sbjct: 322 KAQGKNKHFKVQLKETVYCIGQR-----KFSTMEELVEHYK 357
>gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens]
Length = 225
Score = 46.2 bits (108), Expect = 7e-05
Identities = 29/91 (31%), Positives = 45/91 (49%), Gaps = 5/91 (5%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
YW + EA LL +P GTFL+RDS+ + + F++S + + + + RI+ +FS +
Sbjct: 47 YWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQS 106
Query: 442 HDP----CVFHSSTVTGLLEHYKDPSSCMFF 468
DP V V L+ HY P F
Sbjct: 107 -DPRSTQPVPRFDCVLKLVHHYMPPPGAPSF 136
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 44.3 bits (103), Expect = 3e-04
Identities = 42/144 (29%), Positives = 62/144 (43%), Gaps = 19/144 (13%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSA---QEDYLFSVSFRRYNRSLHARIEQWNHNFS 438
YWG + R E L P+GTFL+RD++ Q DY ++ N+ + + FS
Sbjct: 66 YWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFS 125
Query: 439 FDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTY 498
DP F+S V L+ HY S + P L + L +P S R +
Sbjct: 126 ----DPLTFNS--VVELINHYHHESLAQ-YNPKLDVKL--MYPVS-----RYQQDQLVKE 171
Query: 499 DGIDGLPLPSMLQDFLKEYHYKQK 522
D ID + LQ++ +Y K K
Sbjct: 172 DNIDA--VGKKLQEYHSQYQEKSK 193
Score = 33.1 bits (74), Expect = 0.66
Identities = 16/31 (51%), Positives = 23/31 (74%), Gaps = 2/31 (6%)
Query: 383 WGVMD--RYEAEALLEGKPEGTFLLRDSAQE 411
W V D R +AE LL GKP+G FL+R+S+++
Sbjct: 358 WFVEDINRVQAEDLLYGKPDGAFLIRESSKK 388
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 44.3 bits (103), Expect = 3e-04
Identities = 42/144 (29%), Positives = 62/144 (43%), Gaps = 19/144 (13%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSA---QEDYLFSVSFRRYNRSLHARIEQWNHNFS 438
YWG + R E L P+GTFL+RD++ Q DY ++ N+ + + FS
Sbjct: 66 YWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFS 125
Query: 439 FDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTY 498
DP F+S V L+ HY S + P L + L +P S R +
Sbjct: 126 ----DPLTFNS--VVELINHYHHESLAQ-YNPKLDVKL--MYPVS-----RYQQDQLVKE 171
Query: 499 DGIDGLPLPSMLQDFLKEYHYKQK 522
D ID + LQ++ +Y K K
Sbjct: 172 DNIDA--VGKKLQEYHSQYQEKSK 193
Score = 33.1 bits (74), Expect = 0.66
Identities = 16/31 (51%), Positives = 23/31 (74%), Gaps = 2/31 (6%)
Query: 383 WGVMD--RYEAEALLEGKPEGTFLLRDSAQE 411
W V D R +AE LL GKP+G FL+R+S+++
Sbjct: 358 WFVEDINRVQAEDLLYGKPDGAFLIRESSKK 388
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/39 (53%), Positives = 27/39 (69%), Gaps = 2/39 (5%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQE--DYLFSVS 418
YWG + R EA ALL+G+ G FL+RDS+ DY+ SVS
Sbjct: 14 YWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVS 52
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/39 (53%), Positives = 27/39 (69%), Gaps = 2/39 (5%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQE--DYLFSVS 418
YWG + R EA ALL+G+ G FL+RDS+ DY+ SVS
Sbjct: 14 YWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVS 52
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 42.4 bits (98), Expect = 0.001
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%)
Query: 375 QITGNPCYWGVMDRYEAE-ALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQW 433
+ G Y+G + R++AE AL E EG FL+RDS FSVS + ++ H +++
Sbjct: 279 RFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLV 338
Query: 434 NHNFSFDAHDPCVFHSSTVTGLLEHYK 460
++ + FH T+ L+EHYK
Sbjct: 339 DNVYCIGQRR---FH--TMDELVEHYK 360
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 42.4 bits (98), Expect = 0.001
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%)
Query: 375 QITGNPCYWGVMDRYEAE-ALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQW 433
+ G Y+G + R++AE AL E EG FL+RDS FSVS + ++ H +++
Sbjct: 279 RFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLV 338
Query: 434 NHNFSFDAHDPCVFHSSTVTGLLEHYK 460
++ + FH T+ L+EHYK
Sbjct: 339 DNVYCIGQRR---FH--TMDELVEHYK 360
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 10/98 (10%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQE---DYLFSVSFRRYNRSLHARIEQWNHNFS 438
YWG + R E L +GTFL+RD++ + DY ++ N+ + + FS
Sbjct: 64 YWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFS 123
Query: 439 FDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISL 476
DP F S+V L+ HY++ S + P L + L
Sbjct: 124 ----DPLTF--SSVVELINHYRNESLAQ-YNPKLDVKL 154
Score = 32.0 bits (71), Expect = 1.5
Identities = 14/28 (50%), Positives = 22/28 (78%)
Query: 384 GVMDRYEAEALLEGKPEGTFLLRDSAQE 411
G +R +AE LL GK +GTFL+R+S+++
Sbjct: 357 GSSNRNKAENLLRGKRDGTFLVRESSKQ 384
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 10/98 (10%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQE---DYLFSVSFRRYNRSLHARIEQWNHNFS 438
YWG + R E L +GTFL+RD++ + DY ++ N+ + + FS
Sbjct: 34 YWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFS 93
Query: 439 FDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISL 476
DP F S+V L+ HY++ S + P L + L
Sbjct: 94 ----DPLTF--SSVVELINHYRNESLAQ-YNPKLDVKL 124
Score = 32.0 bits (71), Expect = 1.5
Identities = 14/28 (50%), Positives = 22/28 (78%)
Query: 384 GVMDRYEAEALLEGKPEGTFLLRDSAQE 411
G +R +AE LL GK +GTFL+R+S+++
Sbjct: 327 GSSNRNKAENLLRGKRDGTFLVRESSKQ 354
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 10/98 (10%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQE---DYLFSVSFRRYNRSLHARIEQWNHNFS 438
YWG + R E L +GTFL+RD++ + DY ++ N+ + + FS
Sbjct: 334 YWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFS 393
Query: 439 FDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISL 476
DP F S+V L+ HY++ S + P L + L
Sbjct: 394 ----DPLTF--SSVVELINHYRNESLAQ-YNPKLDVKL 424
Score = 32.0 bits (71), Expect = 1.5
Identities = 14/28 (50%), Positives = 22/28 (78%)
Query: 384 GVMDRYEAEALLEGKPEGTFLLRDSAQE 411
G +R +AE LL GK +GTFL+R+S+++
Sbjct: 627 GSSNRNKAENLLRGKRDGTFLVRESSKQ 654
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 39.3 bits (90), Expect = 0.009
Identities = 26/89 (29%), Positives = 42/89 (47%), Gaps = 9/89 (10%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSA---QEDYLFSVSFRRYNRSLHARIEQWNHNFS 438
YWG + R E L P+GTFL+RD++ Q +Y ++ N+ + ++ FS
Sbjct: 331 YWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFS 390
Query: 439 FDAHDPCVFHSSTVTGLLEHYKDPSSCMF 467
+P F S V L+ HY+ S +
Sbjct: 391 ----EPLTFCS--VVDLINHYRHESLAQY 413
Score = 35.4 bits (80), Expect = 0.13
Identities = 15/29 (51%), Positives = 23/29 (79%)
Query: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQ 410
Y G ++R +AE +L GK +GTFL+R+S+Q
Sbjct: 623 YVGKINRTQAEEMLSGKRDGTFLIRESSQ 651
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 39.3 bits (90), Expect = 0.009
Identities = 26/69 (37%), Positives = 39/69 (56%), Gaps = 3/69 (4%)
Query: 372 DLLQITGNPCYWGVMDRYEAEALLEGKP-EGTFLLRDSAQEDYLFSVSFRRYNRSLHARI 430
+LLQ G Y G + R+ AEALL +G++LLRDS + L+S+S R + H +
Sbjct: 28 ELLQDLG--WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHV 85
Query: 431 EQWNHNFSF 439
E ++F F
Sbjct: 86 EYTGYSFKF 94
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 36.6 bits (83), Expect = 0.059
Identities = 18/61 (29%), Positives = 32/61 (52%)
Query: 370 VPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHAR 429
VP + + P Y G M+R +AE L + T+L+R +E +++S + N + H +
Sbjct: 101 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK 160
Query: 430 I 430
I
Sbjct: 161 I 161
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 36.6 bits (83), Expect = 0.059
Identities = 18/61 (29%), Positives = 32/61 (52%)
Query: 370 VPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHAR 429
VP + + P Y G M+R +AE L + T+L+R +E +++S + N + H +
Sbjct: 661 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK 720
Query: 430 I 430
I
Sbjct: 721 I 721
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 36.6 bits (83), Expect = 0.059
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 10/98 (10%)
Query: 91 EISIEKDNDSCVTPGTRLARRDSYSRHAPWGGK--KKHSCSTKTQSSLDADKKFGRTRSG 148
E ++ D+D P + +DS S+ K +K CS+ + SSL KK + R+G
Sbjct: 1866 ETDLDSDDDKIEKPNNFM--KDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTG 1923
Query: 149 LQRRERRYGVSSVH------DMDSVSSRTVGSRSLRQR 180
L R RR ++ + D++ VS V +RS R
Sbjct: 1924 LLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGR 1961
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 36.6 bits (83), Expect = 0.059
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 10/98 (10%)
Query: 91 EISIEKDNDSCVTPGTRLARRDSYSRHAPWGGK--KKHSCSTKTQSSLDADKKFGRTRSG 148
E ++ D+D P + +DS S+ K +K CS+ + SSL KK + R+G
Sbjct: 1866 ETDLDSDDDKIEKPNNFM--KDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTG 1923
Query: 149 LQRRERRYGVSSVH------DMDSVSSRTVGSRSLRQR 180
L R RR ++ + D++ VS V +RS R
Sbjct: 1924 LLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGR 1961
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 35.4 bits (80), Expect = 0.13
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 385 VMDRYEAEALLE------GKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFS 438
V R AE LL+ G +GTFL+R+S +++SF R R H RI +
Sbjct: 537 VEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGT 596
Query: 439 FDAHDPCVFHSSTVTGLLEHYKDPS-SCMFFEPLLT 473
+ S++ L++HY++ C FE LT
Sbjct: 597 LKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLT 632
Score = 31.2 bits (69), Expect = 2.5
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 370 VPDLLQITGNPCYWGVMDRYEAEALLEGKP-EGTFLLRDSAQEDYLFSVSFRRYNRSLHA 428
VP+ P Y+ + R EAE +L P +G FL+R D ++++FR + H
Sbjct: 635 VPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSD-SYAITFRARGKVKHC 693
Query: 429 RIEQWNHNF 437
RI + +F
Sbjct: 694 RINRDGRHF 702
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 35.0 bits (79), Expect = 0.17
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 374 LQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARI--- 430
+ T P + G M+R + + LL+ GT+L+R+ E F++S + + H ++
Sbjct: 666 IDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEK 725
Query: 431 EQWNH 435
+ W H
Sbjct: 726 DNWIH 730
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 35.0 bits (79), Expect = 0.17
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 374 LQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARI--- 430
+ T P + G M+R + + LL+ GT+L+R+ E F++S + + H ++
Sbjct: 656 IDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEK 715
Query: 431 EQWNH 435
+ W H
Sbjct: 716 DNWIH 720
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,294,987
Number of Sequences: 37866
Number of extensions: 1044140
Number of successful extensions: 2808
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 2716
Number of HSP's gapped (non-prelim): 120
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.