Guide to the Human Genome
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Search of human proteins with 7019561

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo
sapiens]
         (1024 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo ...  2085   0.0  
gi|157266300 membrane alanine aminopeptidase precursor [Homo sap...   570   e-162
gi|132814467 glutamyl aminopeptidase [Homo sapiens]                   504   e-142
gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]    495   e-139
gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]     495   e-139
gi|94818891 type 1 tumor necrosis factor receptor shedding amino...   478   e-134
gi|94818901 type 1 tumor necrosis factor receptor shedding amino...   478   e-134
gi|194239713 laeverin [Homo sapiens]                                  473   e-133
gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens]   460   e-129
gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens]   460   e-129
gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]        390   e-108
gi|4505029 leukotriene A4 hydrolase [Homo sapiens]                     85   3e-16
gi|40316915 arginyl aminopeptidase [Homo sapiens]                      80   1e-14
gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Ho...    67   1e-10
gi|188536004 zinc finger protein 469 [Homo sapiens]                    35   0.28 
gi|21389407 hexamthylene bis-acetamide inducible 2 [Homo sapiens]      35   0.28 
gi|4507347 TBP-associated factor 2 [Homo sapiens]                      35   0.28 
gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]       35   0.36 
gi|116256354 alpha 2 type IV collagen preproprotein [Homo sapiens]     35   0.36 
gi|153267418 EDAR-associated death domain isoform A [Homo sapiens]     34   0.62 
gi|18152769 EDAR-associated death domain isoform B [Homo sapiens]      34   0.62 
gi|239756892 PREDICTED: hypothetical protein [Homo sapiens]            34   0.81 
gi|239751388 PREDICTED: hypothetical protein XP_002347834 [Homo ...    34   0.81 
gi|239745895 PREDICTED: hypothetical protein XP_002343612 [Homo ...    34   0.81 
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    34   0.81 
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      33   1.4  
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]                 33   1.8  
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]       32   2.3  
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]       32   3.1  
gi|239744898 PREDICTED: hypothetical protein XP_002343297 [Homo ...    32   3.1  

>gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo
            sapiens]
          Length = 1024

 Score = 2085 bits (5401), Expect = 0.0
 Identities = 1024/1024 (100%), Positives = 1024/1024 (100%)

Query: 1    MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVL 60
            MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVL
Sbjct: 1    MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVL 60

Query: 61   LSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTT 120
            LSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTT
Sbjct: 61   LSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTT 120

Query: 121  SAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYV 180
            SAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYV
Sbjct: 121  SAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYV 180

Query: 181  VLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNAL 240
            VLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNAL
Sbjct: 181  VLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNAL 240

Query: 241  IENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLS 300
            IENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLS
Sbjct: 241  IENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLS 300

Query: 301  LSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDA 360
            LSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDA
Sbjct: 301  LSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDA 360

Query: 361  IRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRIL 420
            IRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRIL
Sbjct: 361  IRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRIL 420

Query: 421  LDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPG 480
            LDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPG
Sbjct: 421  LDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPG 480

Query: 481  WNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANF 540
            WNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANF
Sbjct: 481  WNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANF 540

Query: 541  MGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVI 600
            MGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVI
Sbjct: 541  MGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVI 600

Query: 601  TILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIW 660
            TILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIW
Sbjct: 601  TILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIW 660

Query: 661  VSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGL 720
            VSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGL
Sbjct: 661  VSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGL 720

Query: 721  IDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEY 780
            IDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEY
Sbjct: 721  IDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEY 780

Query: 781  ILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDW 840
            ILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDW
Sbjct: 781  ILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDW 840

Query: 841  ISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNL 900
            ISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNL
Sbjct: 841  ISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNL 900

Query: 901  LNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK 960
            LNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK
Sbjct: 901  LNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK 960

Query: 961  LISGVTEFLNTEGELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGK 1020
            LISGVTEFLNTEGELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGK
Sbjct: 961  LISGVTEFLNTEGELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGK 1020

Query: 1021 ALRH 1024
            ALRH
Sbjct: 1021 ALRH 1024


>gi|157266300 membrane alanine aminopeptidase precursor [Homo sapiens]
          Length = 967

 Score =  570 bits (1468), Expect = e-162
 Identities = 331/946 (34%), Positives = 495/946 (52%), Gaps = 41/946 (4%)

Query: 95   SARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLML 154
            S  +N +A      P A    S   T+  P S    +  + W + RL   LKP  Y + L
Sbjct: 34   SQEKNKNANSS---PVASTTPSASATT-NPASATTLDQSKAWNRYRLPNTLKPDSYRVTL 89

Query: 155  TAFMEN-----FTFSGEVNVEIACRNATRYVVLHASRVAVEKVQ---LAEDRAFGAVP-- 204
              ++       + F G   V   C+ AT  +++H+ ++     Q   +      G+ P  
Sbjct: 90   RPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPD 149

Query: 205  VAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGERRFLGV 264
            +    L   T+ LVV L  +L     Y +   +   + ++L GF+RS Y+    R+ +  
Sbjct: 150  IDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVAT 209

Query: 265  TQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVE---TSVFEEDGWVTDHF 321
            TQ     ARK+FPCFDEP  KA F I++ H     +LSNM  +   T + E+  W    F
Sbjct: 210  TQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEF 269

Query: 322  SQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYE 381
              TP MSTY LA+ +  F Y E    +GV++R++ARP AI  G GDYAL++T  ++ F+ 
Sbjct: 270  HTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFA 329

Query: 382  DYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 441
             ++  PY LPK D + +P     AMENWGL  + E  +L DP  SS S    V  VI HE
Sbjct: 330  GHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHE 389

Query: 442  ICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDG 501
            + HQWFG+LVT  WW D+WL EGFA Y E++G DY  P WN++    L DV + VM +D 
Sbjct: 390  LAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDV-YRVMAVDA 448

Query: 502  LASSHPVS---QEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHK 558
            LASSHP+S    E+     I  +FD I+Y KGA+++RML++F+   VF++GL  YL    
Sbjct: 449  LASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFA 508

Query: 559  YGNAARNDLWNTLSEALKRNGKYV--NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQ 616
            Y N    +LW+ L EA+      +   ++++M++WTLQMG+PVIT+  +T       ++Q
Sbjct: 509  YQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGT-----LSQ 563

Query: 617  QHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKG 676
            +HF+ D    +   +    +Y+W +P+T +   R     +   W+ +    + +      
Sbjct: 564  EHFLLD--PDSNVTRPSEFNYVWIVPITSIRDGR----QQQDYWLIDVRAQNDLFSTSGN 617

Query: 677  SWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQN 736
             W+L N+N TGY+RVNYD  NWR +  QL R+H  + V NRA +I+DAF+LA A  +P  
Sbjct: 618  EWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVT 677

Query: 737  IPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPK 796
            + L    +L EE+ ++PW AA  +L     + DR E Y     Y+ KQV   +I      
Sbjct: 678  LALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNT 737

Query: 797  NNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISS-NRNRIPLNVRDI 855
            NN+         Q+ E+    I  ACS G   C +  S L   W+ + N N I  N+R  
Sbjct: 738  NNWREIPENLMDQYSEV--NAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRST 795

Query: 856  VYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVL 915
            VYC  ++   E+ W+F W +F + T V+E   L  AL CS +  +LNR L+ +LN +++ 
Sbjct: 796  VYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIR 855

Query: 916  DQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGEL 975
             QDA   II +  N  G+ L W F +  WK L   YG   F  S LI  VT   +TE EL
Sbjct: 856  KQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYEL 915

Query: 976  KELKNFMKNYD----GVAAASFSRAVETVEANVRWKMLYQDELFQW 1017
            ++L+ F K+ +    G    +  +A+E  +AN++W    ++ + QW
Sbjct: 916  QQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQW 961


>gi|132814467 glutamyl aminopeptidase [Homo sapiens]
          Length = 957

 Score =  504 bits (1297), Expect = e-142
 Identities = 329/1004 (32%), Positives = 508/1004 (50%), Gaps = 79/1004 (7%)

Query: 30   TERHIAVHKRLVLAFAVSLVALLAVTMLAVLLSLRFDECGASATPGADGGPSGFPERGGN 89
            ++R+    K + +  AV +V +  +  LAV L+   D  G       DGGP   P     
Sbjct: 9    SKRYCIQTKHVAILCAV-VVGVGLIVGLAVGLTRSCDSSG-------DGGPGTAP---AP 57

Query: 90   GSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQ-----PPSEEEREPWEPWTQLRLSGH 144
              LP S                   ASP    AQ     P SE+E   W+     RL   
Sbjct: 58   SHLPSST------------------ASPSGPPAQDQDICPASEDESGQWK---NFRLPDF 96

Query: 145  LKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAEDRAFGAVP 204
            + P+HY+L +   +E  T++G V++ I     TRY+ LH     + ++   +  +   V 
Sbjct: 97   VNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQ 156

Query: 205  VAGFFLYPQTQVLVVVLNRTLDAQRN---YNLKIIYNALIENELLGFFRSSYVLHGERRF 261
            V   F Y + + +VV     L        Y L + +   +   L+GF+R++Y  +G+ + 
Sbjct: 157  VRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKS 216

Query: 262  LGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHF 321
            +  T   PT ARK+FPCFDEP  KAT+ ISI H   Y +LSNMPV      +D W    F
Sbjct: 217  IVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTF 276

Query: 322  SQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYE 381
             ++  MSTY + +A+  F   +  + SG  + +Y +P+  ++ + +YA +ITK + +++E
Sbjct: 277  EKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPE--QKHTAEYAANITKSVFDYFE 334

Query: 382  DYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 441
            +YF + YSLPKLD +A+P     AMENWGL  + E  +L DP  S+ S    V  V+ HE
Sbjct: 335  EYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHE 394

Query: 442  ICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDG 501
            + HQWFG++VT  WWED+WL EGFA +FEF+G ++    W M  Q  L DVL  V   D 
Sbjct: 395  LVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVL-PVQEDDS 453

Query: 502  LASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGN 561
            L SSHP+   V    +I  VFD I+Y KG++++RML +++    FQ+G Q YL  +++ N
Sbjct: 454  LMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKN 513

Query: 562  AARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIY 621
            A  +D W  L EA +     + ++EVMD WT QMGYPV+ + G         ITQ+ F+ 
Sbjct: 514  AKTSDFWAALEEASR-----LPVKEVMDTWTRQMGYPVLNVNGVKN------ITQKRFLL 562

Query: 622  DISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDK----GS 677
            D  A   +    +  Y W IP   V     +++S  +    N+SE   IT         +
Sbjct: 563  DPRA-NPSQPPSDLGYTWNIP---VKWTEDNITSSVLF---NRSEKEGITLNSSNPSGNA 615

Query: 678  WLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNI 737
            +L  N +  G++RVNY++  W  +   L  NH+  S ++RA LIDDAF+LARA  L   +
Sbjct: 616  FLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKV 675

Query: 738  PLEIIRYLSEEKDFLPW-HAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPK 796
             L + +YL  E++FLPW    S   Y +    D  E Y +  EY   QV      LGW  
Sbjct: 676  ALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGW-- 733

Query: 797  NNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIV 856
             N  G  V      + LR  V+  AC  G++     AS+L   W++   + +P+N+R +V
Sbjct: 734  -NDAGDHVT-----KLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVS-LPVNLRLLV 786

Query: 857  YCTGVSLLDEDV-WEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVL 915
            Y  G+     ++ W +   ++  T+   EK+ LL  L    +  LL+R L+L  ++ ++ 
Sbjct: 787  YRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIK 846

Query: 916  DQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGEL 975
             QD   VI +++ N +G+++AW + +  W  L  RY      N   I  + E  NTE +L
Sbjct: 847  TQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRY-TLNNRNLGRIVTIAEPFNTELQL 905

Query: 976  KELKNFMKNYDGVAAASFSR--AVETVEANVRWKMLYQDELFQW 1017
             ++++F   Y    A    R   +ETV+ N+ W   +++ + +W
Sbjct: 906  WQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949


>gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
          Length = 960

 Score =  495 bits (1274), Expect = e-139
 Identities = 299/914 (32%), Positives = 467/914 (51%), Gaps = 50/914 (5%)

Query: 135  PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194
            PW +LRL   + PLHY+L +   + +  F     +E+   NAT++++LH+  + +    L
Sbjct: 63   PWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATL 122

Query: 195  AED---RAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRS 251
              +   R            YP  + + +++   L     Y + + + A + +   GF++S
Sbjct: 123  QSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKS 182

Query: 252  SY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSV 310
            +Y  L GE R L VT F PT AR AFPCFDEP++KA F I I+ ++ +++LSNMP   ++
Sbjct: 183  TYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTI 242

Query: 311  FEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYAL 370
              E G + DHF  T  MSTY +A+ +C+F      T SGV V +YA PD  +R    YAL
Sbjct: 243  ELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPD--KRNQTHYAL 300

Query: 371  HITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISY 430
              + +L++FYE YF + Y L KLDL+A+P     AMENWGL  + E  +L DP  SS S 
Sbjct: 301  QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360

Query: 431  LLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLT 490
             L VT VI HE+ HQWFG+LVT  WW D+WLKEGFA Y E +  +  YP   ++   +  
Sbjct: 361  KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYP--ELQFDDYFL 418

Query: 491  DVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGL 550
            +V  EV+  D L SS P+S+     T I  +FD ++Y KGA ++ ML +F+G   FQ+G+
Sbjct: 419  NVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGI 478

Query: 551  QDYLTIHKYGNAARNDLWNTLSEALKRN----------------------GKYVNIQEVM 588
              YL    Y NA  +DLW++LS +   +                      G+   ++E+M
Sbjct: 479  IQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMM 538

Query: 589  DQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVG 648
              WTLQ G P++ +  +  +   + + Q+ F+  +  +    +     YLW IPLT    
Sbjct: 539  TTWTLQKGIPLLVVKQDGCS---LRLQQERFLQGVFQEDPEWRALQERYLWHIPLTY--- 592

Query: 649  NRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRN 708
              S  SS  I     KS+   +   +K SW+  N++  GY+ V+Y+   W  LI QL +N
Sbjct: 593  --STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650

Query: 709  HEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLL 768
            H +L   +R GLI D F L  AG L  +  L++  YL  E       A    L  L+   
Sbjct: 651  HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLESFY 707

Query: 769  DRMENYNIFN-EYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNK 827
              M+  NI +    LK+    Y K    + +++    + S     LR  ++ LAC   + 
Sbjct: 708  HMMDRRNISDISENLKRYLLQYFKPVIDRQSWSD---KGSVWDRMLRSALLKLACDLNHA 764

Query: 828  HCHQQASTLISDWI-SSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKK 886
             C Q+A+ L S W+ SS +  IP +V  IVY  G        W ++  ++  + + +E+ 
Sbjct: 765  PCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAG--WNYLLEQYELSMSSAEQN 822

Query: 887  ILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKI 946
             +L AL+ S  +  L +L+ L +  +V+  Q+   ++  +AR P G+ LAW F R+ W  
Sbjct: 823  KILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTH 882

Query: 947  LNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYD--GVAAASFSRAVETVEANV 1004
            L  ++    +    +ISG T   +++ +L+E+K F ++ +  G     F   +ET+  N+
Sbjct: 883  LLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNI 942

Query: 1005 RWKMLYQDELFQWL 1018
            +W       L  WL
Sbjct: 943  KWLEKNLPTLRTWL 956


>gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
          Length = 960

 Score =  495 bits (1274), Expect = e-139
 Identities = 299/914 (32%), Positives = 467/914 (51%), Gaps = 50/914 (5%)

Query: 135  PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194
            PW +LRL   + PLHY+L +   + +  F     +E+   NAT++++LH+  + +    L
Sbjct: 63   PWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATL 122

Query: 195  AED---RAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRS 251
              +   R            YP  + + +++   L     Y + + + A + +   GF++S
Sbjct: 123  QSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKS 182

Query: 252  SY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSV 310
            +Y  L GE R L VT F PT AR AFPCFDEP++KA F I I+ ++ +++LSNMP   ++
Sbjct: 183  TYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTI 242

Query: 311  FEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYAL 370
              E G + DHF  T  MSTY +A+ +C+F      T SGV V +YA PD  +R    YAL
Sbjct: 243  ELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPD--KRNQTHYAL 300

Query: 371  HITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISY 430
              + +L++FYE YF + Y L KLDL+A+P     AMENWGL  + E  +L DP  SS S 
Sbjct: 301  QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360

Query: 431  LLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLT 490
             L VT VI HE+ HQWFG+LVT  WW D+WLKEGFA Y E +  +  YP   ++   +  
Sbjct: 361  KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYP--ELQFDDYFL 418

Query: 491  DVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGL 550
            +V  EV+  D L SS P+S+     T I  +FD ++Y KGA ++ ML +F+G   FQ+G+
Sbjct: 419  NVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGI 478

Query: 551  QDYLTIHKYGNAARNDLWNTLSEALKRN----------------------GKYVNIQEVM 588
              YL    Y NA  +DLW++LS +   +                      G+   ++E+M
Sbjct: 479  IQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMM 538

Query: 589  DQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVG 648
              WTLQ G P++ +  +  +   + + Q+ F+  +  +    +     YLW IPLT    
Sbjct: 539  TTWTLQKGIPLLVVKQDGCS---LRLQQERFLQGVFQEDPEWRALQERYLWHIPLTY--- 592

Query: 649  NRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRN 708
              S  SS  I     KS+   +   +K SW+  N++  GY+ V+Y+   W  LI QL +N
Sbjct: 593  --STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650

Query: 709  HEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLL 768
            H +L   +R GLI D F L  AG L  +  L++  YL  E       A    L  L+   
Sbjct: 651  HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLESFY 707

Query: 769  DRMENYNIFN-EYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNK 827
              M+  NI +    LK+    Y K    + +++    + S     LR  ++ LAC   + 
Sbjct: 708  HMMDRRNISDISENLKRYLLQYFKPVIDRQSWSD---KGSVWDRMLRSALLKLACDLNHA 764

Query: 828  HCHQQASTLISDWI-SSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKK 886
             C Q+A+ L S W+ SS +  IP +V  IVY  G        W ++  ++  + + +E+ 
Sbjct: 765  PCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAG--WNYLLEQYELSMSSAEQN 822

Query: 887  ILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKI 946
             +L AL+ S  +  L +L+ L +  +V+  Q+   ++  +AR P G+ LAW F R+ W  
Sbjct: 823  KILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTH 882

Query: 947  LNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYD--GVAAASFSRAVETVEANV 1004
            L  ++    +    +ISG T   +++ +L+E+K F ++ +  G     F   +ET+  N+
Sbjct: 883  LLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNI 942

Query: 1005 RWKMLYQDELFQWL 1018
            +W       L  WL
Sbjct: 943  KWLEKNLPTLRTWL 956


>gi|94818891 type 1 tumor necrosis factor receptor shedding
            aminopeptidase regulator isoform b [Homo sapiens]
          Length = 941

 Score =  478 bits (1230), Expect = e-134
 Identities = 285/925 (30%), Positives = 456/925 (49%), Gaps = 61/925 (6%)

Query: 125  PSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHA 184
            P   +  P+ PW ++RL  ++ P+HY+L++ A +   TF G   VEI     T  ++LH+
Sbjct: 39   PKRSDGTPF-PWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHS 97

Query: 185  SRVAVEKVQLAEDRA--FGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIE 242
              + + +  L +         P+     +P+ + + ++    L     Y + I Y   + 
Sbjct: 98   HHLQISRATLRKGAGERLSEEPLQ-VLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLS 156

Query: 243  NELLGFFRSSY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSL 301
                GF++S+Y    GE R L  TQF PT AR AFPCFDEP +KA+F I I+ +  +L++
Sbjct: 157  ETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAI 216

Query: 302  SNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAI 361
            SNMP+  SV   +G + DHF  T  MSTY +A+ I +F      TKSGV V +YA PD I
Sbjct: 217  SNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKI 276

Query: 362  RRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILL 421
             +   DYAL     L+EFYEDYF +PY LPK DL A+P     AMENWGL+ + E  +L 
Sbjct: 277  NQA--DYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLF 334

Query: 422  DPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGW 481
            D   SS S  L +TM + HE+ HQWFG+LVT  WW D+WL EGFA + EFV     +P  
Sbjct: 335  DAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHP-- 392

Query: 482  NMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFM 541
             ++   +      + M +D L SSHPVS  V     I  +FD ++Y KGA ++ ML  ++
Sbjct: 393  ELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYL 452

Query: 542  GHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNG---------------------- 579
                F+ G+  YL  H Y N    DLW++++     +G                      
Sbjct: 453  SADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQ 512

Query: 580  KYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLW 639
            + V+++ +M+ WTLQ G+P+ITI   T     + + Q+H++             +  YLW
Sbjct: 513  EGVDVKTMMNTWTLQKGFPLITI---TVRGRNVHMKQEHYMKGSDG------APDTGYLW 563

Query: 640  QIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWR 699
             +PLT +      V    +     K++   +   ++  W+  N+   GY+ V+Y+   W 
Sbjct: 564  HVPLTFITSKSDMVHRFLL-----KTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWD 618

Query: 700  LLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASR 759
             L   L   H  +S ++RA LI++AF L   G L     L++  YL  E + +P      
Sbjct: 619  SLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLN 678

Query: 760  ALYPLDKLLDRMENYNI---FNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRRE 816
             L P+ KL+++ +   +   F  ++++ +     K  W          + S     LR +
Sbjct: 679  ELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTD--------EGSVSERMLRSQ 730

Query: 817  VIMLACSFGNKHCHQQASTLISDWISSNRN-RIPLNVRDIVYCTGVSLLDEDVWEFIWMK 875
            +++LAC    + C Q+A      W  SN N  +P++V   V+  G      + W+F++ K
Sbjct: 731  LLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQ--STEGWDFLYSK 788

Query: 876  FHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDL 935
            +  + + +EK  +  AL  + ++  L  LL+ S   + +  Q+   ++  + RNP G  L
Sbjct: 789  YQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPL 848

Query: 936  AWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNY--DGVAAASF 993
            AW+F R  W  L  ++       + ++ G T   +T   L+E+K F  +   +G      
Sbjct: 849  AWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCV 908

Query: 994  SRAVETVEANVRWKMLYQDELFQWL 1018
             + +ET+E N+ W     D++  WL
Sbjct: 909  QQTIETIEENIGWMDKNFDKIRVWL 933


>gi|94818901 type 1 tumor necrosis factor receptor shedding
            aminopeptidase regulator isoform a [Homo sapiens]
          Length = 948

 Score =  478 bits (1230), Expect = e-134
 Identities = 285/925 (30%), Positives = 456/925 (49%), Gaps = 61/925 (6%)

Query: 125  PSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHA 184
            P   +  P+ PW ++RL  ++ P+HY+L++ A +   TF G   VEI     T  ++LH+
Sbjct: 39   PKRSDGTPF-PWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHS 97

Query: 185  SRVAVEKVQLAEDRA--FGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIE 242
              + + +  L +         P+     +P+ + + ++    L     Y + I Y   + 
Sbjct: 98   HHLQISRATLRKGAGERLSEEPLQ-VLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLS 156

Query: 243  NELLGFFRSSY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSL 301
                GF++S+Y    GE R L  TQF PT AR AFPCFDEP +KA+F I I+ +  +L++
Sbjct: 157  ETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAI 216

Query: 302  SNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAI 361
            SNMP+  SV   +G + DHF  T  MSTY +A+ I +F      TKSGV V +YA PD I
Sbjct: 217  SNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKI 276

Query: 362  RRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILL 421
             +   DYAL     L+EFYEDYF +PY LPK DL A+P     AMENWGL+ + E  +L 
Sbjct: 277  NQA--DYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLF 334

Query: 422  DPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGW 481
            D   SS S  L +TM + HE+ HQWFG+LVT  WW D+WL EGFA + EFV     +P  
Sbjct: 335  DAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHP-- 392

Query: 482  NMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFM 541
             ++   +      + M +D L SSHPVS  V     I  +FD ++Y KGA ++ ML  ++
Sbjct: 393  ELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYL 452

Query: 542  GHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNG---------------------- 579
                F+ G+  YL  H Y N    DLW++++     +G                      
Sbjct: 453  SADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQ 512

Query: 580  KYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLW 639
            + V+++ +M+ WTLQ G+P+ITI   T     + + Q+H++             +  YLW
Sbjct: 513  EGVDVKTMMNTWTLQKGFPLITI---TVRGRNVHMKQEHYMKGSDG------APDTGYLW 563

Query: 640  QIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWR 699
             +PLT +      V    +     K++   +   ++  W+  N+   GY+ V+Y+   W 
Sbjct: 564  HVPLTFITSKSDMVHRFLL-----KTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWD 618

Query: 700  LLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASR 759
             L   L   H  +S ++RA LI++AF L   G L     L++  YL  E + +P      
Sbjct: 619  SLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLN 678

Query: 760  ALYPLDKLLDRMENYNI---FNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRRE 816
             L P+ KL+++ +   +   F  ++++ +     K  W          + S     LR +
Sbjct: 679  ELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTD--------EGSVSERMLRSQ 730

Query: 817  VIMLACSFGNKHCHQQASTLISDWISSNRN-RIPLNVRDIVYCTGVSLLDEDVWEFIWMK 875
            +++LAC    + C Q+A      W  SN N  +P++V   V+  G      + W+F++ K
Sbjct: 731  LLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQ--STEGWDFLYSK 788

Query: 876  FHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDL 935
            +  + + +EK  +  AL  + ++  L  LL+ S   + +  Q+   ++  + RNP G  L
Sbjct: 789  YQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPL 848

Query: 936  AWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNY--DGVAAASF 993
            AW+F R  W  L  ++       + ++ G T   +T   L+E+K F  +   +G      
Sbjct: 849  AWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCV 908

Query: 994  SRAVETVEANVRWKMLYQDELFQWL 1018
             + +ET+E N+ W     D++  WL
Sbjct: 909  QQTIETIEENIGWMDKNFDKIRVWL 933


>gi|194239713 laeverin [Homo sapiens]
          Length = 990

 Score =  473 bits (1216), Expect = e-133
 Identities = 290/884 (32%), Positives = 466/884 (52%), Gaps = 52/884 (5%)

Query: 132 PWEPWTQLRLSGHLKPLHYNLMLTAFME-------NFTFSGEVNVEIACRNATRYVVLHA 184
           P  PW QLRL   L PLHY+L L   +        +  F+G VN+ + C  AT  ++LH+
Sbjct: 89  PPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHS 148

Query: 185 SRVAVEKVQL-------AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIY 237
                E+ ++         +   G VPV   +    T+ +V+ L+  L    +Y L++ +
Sbjct: 149 LFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSF 208

Query: 238 NALIENELL-GFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA 296
           + L++ +L  G F + Y   GERR L  +Q  PT AR  FPCFDEP  KATF I++ H  
Sbjct: 209 SGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHP 268

Query: 297 TYLSLSNMPVETSVFEED----GWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVV 352
           +Y++LSNMP      +ED     W    FS TP M TY +A+ IC++ +   T + G  +
Sbjct: 269 SYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTER-GKEI 327

Query: 353 RLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLS 412
           R++AR DAI  GS D+AL+IT  +  F ED F + YSLPK D++A+P     AMENWGL 
Sbjct: 328 RIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLM 387

Query: 413 IFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFV 472
           IF E  +LL+P          ++ V+ HEI HQWFG+LVT  WW ++WL EGFA YFEF 
Sbjct: 388 IFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFE 447

Query: 473 GTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEV--LQATDIDRVFDWIAYKKG 530
             +Y  P      + F +++LH ++  D    +  V+ +V   + ++I  +FD   Y KG
Sbjct: 448 VINYFNPKL-PRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKG 506

Query: 531 AALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV---NIQEV 587
           A++ RML+ F+   +F   L+ YL    Y NA ++DLW     A+      +    I+ +
Sbjct: 507 ASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNI 566

Query: 588 MDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVV 647
           MD WT Q G+PVIT+  +T       + +Q   Y  + K + L   N++  W +P+  + 
Sbjct: 567 MDSWTHQSGFPVITLNVSTG------VMKQEPFYLENIKNRTLLTSNDT--WIVPILWI- 617

Query: 648 GNRSHVSSEAIIWVSNKSE---HHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQ 704
               + +++ ++W+   S+     +++  D   W++ N+N TGY+RVNYD   W+ L  Q
Sbjct: 618 ---KNGTTQPLVWLDQSSKVFPEMQVSDSDH-DWVILNLNMTGYYRVNYDKLGWKKLNQQ 673

Query: 705 LIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPL 764
           L ++ + + V +R  LIDDAFSL++  Y+     LE+ +YL+EE + + WH     L   
Sbjct: 674 LEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTR 733

Query: 765 DKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNF----NGSLVQASYQHEELRREVIML 820
           D L+  +  Y+I++  +LK+     + L W   +     N   +Q  Y       ++ + 
Sbjct: 734 D-LVSEVNIYDIYS--LLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLALISLEKLFVT 790

Query: 821 ACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTT 880
           AC  G + C Q +  L + W+    N IP  ++D+V C G++L  +  W+ +   + +TT
Sbjct: 791 ACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTT 850

Query: 881 AVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFF 940
              EK  L  A++CS D  +LNR +  ++++      +  ++I  VA +  GR +A  F 
Sbjct: 851 NKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNET-NIIEVVASSEVGRYVAKDFL 909

Query: 941 RDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKN 984
            + W+ ++ RYG    +N  LI  +   + T+ ++ EL+ F  N
Sbjct: 910 VNNWQAVSKRYGTQSLIN--LIYTIGRTVTTDLQIVELQQFFSN 951


>gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens]
          Length = 1025

 Score =  460 bits (1184), Expect = e-129
 Identities = 284/888 (31%), Positives = 449/888 (50%), Gaps = 28/888 (3%)

Query: 135  PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194
            PW Q+RL   + PL Y L L   + + TF G V + +     T  ++LH++   + +V  
Sbjct: 162  PWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTF 221

Query: 195  AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYV 254
                       A    Y     + +V    L A  NY LKI Y+A I +   GF+  SY 
Sbjct: 222  MS-AVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYT 280

Query: 255  LHG-ERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEE 313
                E+++   TQF P  AR AFPCFDEP +KATF I I     Y +LSNMP ++SV  +
Sbjct: 281  DESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLD 340

Query: 314  DGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHIT 373
            DG V D FS++  MSTY +A+ +           +G +V +YA P+ I  G   YAL  T
Sbjct: 341  DGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKI--GQVHYALETT 397

Query: 374  KRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD 433
             +L+EF+++YF++ Y L KLDL+A+P     AMENWGL  F E+ +L D + SS++    
Sbjct: 398  VKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKL 457

Query: 434  VTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVL 493
            VT +I HE+ HQWFG+LVT  WW D+WL EGFA + E+   + ++    +       D  
Sbjct: 458  VTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFK--ELSSYEDFLDAR 515

Query: 494  HEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDY 553
             + M  D L SSHP+S  V  +  I+ +FD ++Y KG++L+ ML  ++   VFQ  +  Y
Sbjct: 516  FKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLY 575

Query: 554  LTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRII 613
            L  H Y +   +DLW++ +E   +    ++++ +M  WTLQ G+P++T+         + 
Sbjct: 576  LHNHSYASIQSDDLWDSFNEVTNQT---LDVKRMMKTWTLQKGFPLVTV---QKKGKELF 629

Query: 614  ITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYL 673
            I Q+ F  ++  +   ++  + SYLW IPL+ V   R++   +++  +  KS    +T  
Sbjct: 630  IQQERFFLNMKPE---IQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLT-- 684

Query: 674  DKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYL 733
            ++  W+  NIN  GY+ V+Y   +W  LI QL  N  VLS  +RA LI++ F LA  G +
Sbjct: 685  EEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKV 744

Query: 734  PQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLG 793
            P     ++I YL  E    P    + AL+  D + + +E     +  +  ++ T   KL 
Sbjct: 745  PLKRAFDLINYLGNENHTAP---ITEALFQTDLIYNLLEKLGYMD--LASRLVTRVFKLL 799

Query: 794  WPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNR-IPLNV 852
              +        + +    ELR  ++  AC+    +C   A  L  DW++SN  + +P +V
Sbjct: 800  QNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDV 859

Query: 853  RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSE 912
               V+  G     +  W F+  K+ S  + +EK  +LEAL  S+D   L  L+  SLN +
Sbjct: 860  MTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGD 917

Query: 913  VVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTE 972
                Q    +I  V R+  G  LAW F ++ W  L  ++    +    +++G T   +T+
Sbjct: 918  NFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTK 977

Query: 973  GELKELKNFMKNYDGVA--AASFSRAVETVEANVRWKMLYQDELFQWL 1018
              L E++ F +N             A+E ++ N++W       L  WL
Sbjct: 978  THLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1025


>gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens]
          Length = 1011

 Score =  460 bits (1184), Expect = e-129
 Identities = 284/888 (31%), Positives = 449/888 (50%), Gaps = 28/888 (3%)

Query: 135  PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194
            PW Q+RL   + PL Y L L   + + TF G V + +     T  ++LH++   + +V  
Sbjct: 148  PWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTF 207

Query: 195  AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYV 254
                       A    Y     + +V    L A  NY LKI Y+A I +   GF+  SY 
Sbjct: 208  MS-AVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYT 266

Query: 255  LHG-ERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEE 313
                E+++   TQF P  AR AFPCFDEP +KATF I I     Y +LSNMP ++SV  +
Sbjct: 267  DESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLD 326

Query: 314  DGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHIT 373
            DG V D FS++  MSTY +A+ +           +G +V +YA P+ I  G   YAL  T
Sbjct: 327  DGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKI--GQVHYALETT 383

Query: 374  KRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD 433
             +L+EF+++YF++ Y L KLDL+A+P     AMENWGL  F E+ +L D + SS++    
Sbjct: 384  VKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKL 443

Query: 434  VTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVL 493
            VT +I HE+ HQWFG+LVT  WW D+WL EGFA + E+   + ++    +       D  
Sbjct: 444  VTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFK--ELSSYEDFLDAR 501

Query: 494  HEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDY 553
             + M  D L SSHP+S  V  +  I+ +FD ++Y KG++L+ ML  ++   VFQ  +  Y
Sbjct: 502  FKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLY 561

Query: 554  LTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRII 613
            L  H Y +   +DLW++ +E   +    ++++ +M  WTLQ G+P++T+         + 
Sbjct: 562  LHNHSYASIQSDDLWDSFNEVTNQT---LDVKRMMKTWTLQKGFPLVTV---QKKGKELF 615

Query: 614  ITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYL 673
            I Q+ F  ++  +   ++  + SYLW IPL+ V   R++   +++  +  KS    +T  
Sbjct: 616  IQQERFFLNMKPE---IQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLT-- 670

Query: 674  DKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYL 733
            ++  W+  NIN  GY+ V+Y   +W  LI QL  N  VLS  +RA LI++ F LA  G +
Sbjct: 671  EEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKV 730

Query: 734  PQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLG 793
            P     ++I YL  E    P    + AL+  D + + +E     +  +  ++ T   KL 
Sbjct: 731  PLKRAFDLINYLGNENHTAP---ITEALFQTDLIYNLLEKLGYMD--LASRLVTRVFKLL 785

Query: 794  WPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNR-IPLNV 852
              +        + +    ELR  ++  AC+    +C   A  L  DW++SN  + +P +V
Sbjct: 786  QNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDV 845

Query: 853  RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSE 912
               V+  G     +  W F+  K+ S  + +EK  +LEAL  S+D   L  L+  SLN +
Sbjct: 846  MTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGD 903

Query: 913  VVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTE 972
                Q    +I  V R+  G  LAW F ++ W  L  ++    +    +++G T   +T+
Sbjct: 904  NFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTK 963

Query: 973  GELKELKNFMKNYDGVA--AASFSRAVETVEANVRWKMLYQDELFQWL 1018
              L E++ F +N             A+E ++ N++W       L  WL
Sbjct: 964  THLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1011


>gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]
          Length = 919

 Score =  390 bits (1003), Expect = e-108
 Identities = 275/899 (30%), Positives = 451/899 (50%), Gaps = 45/899 (5%)

Query: 129  EREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVA 188
            E+ P+E     RL   + P++Y+L L   + +FTF G++      R AT  +V++ + + 
Sbjct: 47   EKRPFE-----RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADID 101

Query: 189  VEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGF 248
            +     A +     +   GF    + + + +    TL       LKI +   + +++ GF
Sbjct: 102  IITASYAPE-GDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGF 159

Query: 249  FRSSYVL-HGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV- 306
            +RS Y    GE R+  VTQF  T AR+AFPC+DEP  KATF IS+      ++LSNM V 
Sbjct: 160  YRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVI 219

Query: 307  -ETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGS 365
                  +++  V   F++TP+MSTY +A+ +  + + ET +K GV VR+Y       +G 
Sbjct: 220  DRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 279

Query: 366  GDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSV 425
              +AL +  + + FY+DYF VPY LPK+DL+A+      AMENWGL  + E  +L+DP  
Sbjct: 280  --FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKN 337

Query: 426  SSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEK 485
            S  S    V +V+ HE+ HQWFG+LVT  WW  +WL EGFA + E++  D+ +P +++  
Sbjct: 338  SCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWT 397

Query: 486  QRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSV 545
            Q F++        LD L +SHP+   V   +++D +FD I+Y KGA++IRML +++G   
Sbjct: 398  Q-FVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKD 456

Query: 546  FQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGN 605
            F++G+  YLT  +  NAA  DLW +L  A   +GK   I  VM+ WT QMG+P+I +   
Sbjct: 457  FKKGMNMYLTKFQQKNAATEDLWESLENA---SGK--PIAAVMNTWTKQMGFPLIYVEAE 511

Query: 606  TTAENRII-ITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNK 664
               ++R++ ++Q+ F    S       +  +   W +P+TI      + +   I+ +   
Sbjct: 512  QVEDDRLLRLSQKKFCAGGS------YVGEDCPQWMVPITISTSEDPNQAKLKIL-MDKP 564

Query: 665  SEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVS--NRAGLID 722
              +  +  +    W+  N+   G++R  Y       +++ L+     LS+   +R GL +
Sbjct: 565  EMNVVLKNVKPDQWVKLNLGTVGFYRTQYS----SAMLESLLPGIRDLSLPPVDRLGLQN 620

Query: 723  DAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYIL 782
            D FSLARAG +     L+++     E ++  W   S  L  L  LL   + Y    E++ 
Sbjct: 621  DLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVK 680

Query: 783  KQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWIS 842
               +    +LGW      G L         LR  V+      G+K   ++A     D + 
Sbjct: 681  DVFSPIGERLGWDPKPGEGHL------DALLRGLVLGKLGKAGHKATLEEARRRFKDHV- 733

Query: 843  SNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLE-ALTCSDDRNLL 901
              +  +  ++R  VY T +   D    + I +K H    + E+K  +E  L  +   +L+
Sbjct: 734  EGKQILSADLRSPVYLTVLKHGDGTTLD-IMLKLHKQADMQEEKNRIERVLGATLLPDLI 792

Query: 902  NRLLNLSLNSEVVLDQDAIDVIIHVA-RNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK 960
             ++L  +L SE V  QD + VI  VA  + HGR  AWKF +D W+ L  RY +  F+ S+
Sbjct: 793  QKVLTFAL-SEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRY-QGGFLISR 850

Query: 961  LISGVTEFLNTEGELKELKNFMKNYDGVAA-ASFSRAVETVEANVRWKMLYQDELFQWL 1018
            LI    E    +    E+K F +++   +A  +  +  E +  N  W     + + Q+L
Sbjct: 851  LIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYL 909


>gi|4505029 leukotriene A4 hydrolase [Homo sapiens]
          Length = 611

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 93/372 (25%), Positives = 147/372 (39%), Gaps = 44/372 (11%)

Query: 265 TQFSPTHARKAFPCFDEPIYKATF--KISIKHQATYLSLSNMPVETSVFEEDGWVTDHFS 322
           +Q    H R   PC D P  K T+  ++S+  +   L  +    ET   E+       F 
Sbjct: 134 SQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFI 193

Query: 323 QTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYED 382
           Q   +  Y +A  +     R+   ++ V    ++  + + + +  Y    T+ +++  ED
Sbjct: 194 QKVPIPCYLIALVVGALESRQIGPRTLV----WSEKEQVEKSA--YEFSETESMLKIAED 247

Query: 383 YFKVPYSLPKLDLLAVP-KHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 441
               PY   + DLL +P   PY  MEN  L+      +  D S+S+         VI HE
Sbjct: 248 -LGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSN---------VIAHE 297

Query: 442 ICHQWFGDLVTPVWWEDVWLKEGFAHYFE------FVGTDYLY----PGWNMEKQRFLTD 491
           I H W G+LVT   W+  WL EG   Y E        G  + +     GW   +    T 
Sbjct: 298 ISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKT- 356

Query: 492 VLHEVMLLDGLASSHPVSQEVLQATDIDR--VFDWIAYKKGAALIRMLANFM-GHSVFQR 548
                        +HP ++ V+  TDID    +  + Y+KG AL+  L   + G  +F  
Sbjct: 357 ----------FGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLG 406

Query: 549 GLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTA 608
            L+ Y+    Y +   +D  + L    K     +N Q   + W    G P I    + T 
Sbjct: 407 FLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLN-QVDWNAWLYSPGLPPIKPNYDMTL 465

Query: 609 ENRIIITQQHFI 620
            N  I   Q +I
Sbjct: 466 TNACIALSQRWI 477


>gi|40316915 arginyl aminopeptidase [Homo sapiens]
          Length = 650

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 86/351 (24%), Positives = 147/351 (41%), Gaps = 30/351 (8%)

Query: 257 GERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGW 316
           G+++    TQ      R  FPCFD P  K  +   I+    + ++    +  S +E+ G 
Sbjct: 160 GKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAV----MSASTWEKRGP 215

Query: 317 VTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRL 376
               F     + +Y +A AI +    E   +S    R++A P  I     +Y   + +  
Sbjct: 216 NKFFFQMCQPIPSYLIALAIGDLVSAEVGPRS----RVWAEPCLIDAAKEEYN-GVIEEF 270

Query: 377 IEFYEDYFKVPYSLPKLDLLAVP-KHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVT 435
           +   E  F  PY   + DLL +P   P+  MEN  L+      +  D S++         
Sbjct: 271 LATGEKLFG-PYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLAD-------- 321

Query: 436 MVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFE-FVGTDYLYPGWNMEKQRFLTDVLH 494
            VI+HEI H WFG+LVT   W + WL EGF  Y +  + T      +   +      +L 
Sbjct: 322 -VIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLR 380

Query: 495 EVMLLDGLASSHPVSQ---EVLQATDIDRVFDWIAYKKGAALIRMLANFMG-HSVFQRGL 550
           + M + G    +P+++   ++    D D  ++   Y+KG   +  LA+ +G    F   L
Sbjct: 381 QHMDITG--EENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFL 438

Query: 551 QDYLTIHKYGNAARNDLWNTLSE---ALKRNGKYVNIQEVMDQWTLQMGYP 598
           + Y+   K+ +   +D  +   E    LK+    +      D+W    G+P
Sbjct: 439 KAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWP 489


>gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Homo
           sapiens]
          Length = 494

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 17/187 (9%)

Query: 387 PYSLPKLDLLAVP-KHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQ 445
           PY   + D++ +P   P  AMEN  L+  +   +  D  +     ++DV    +HE+ H 
Sbjct: 77  PYMWGRYDIVFLPPSFPIVAMENPCLTFIISSILESDEFL-----VIDV----IHEVAHS 127

Query: 446 WFGDLVTPVWWEDVWLKEGFAHYFE-FVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLAS 504
           WFG+ VT   WE++WL EG A Y +  + T+     +   +  F  D LH  M L  L  
Sbjct: 128 WFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKL--LGE 185

Query: 505 SHPVSQ---EVLQATDIDRVFDWIAYKKGAALIRMLANFMGH-SVFQRGLQDYLTIHKYG 560
             PVS+   ++    +   + +   Y+KG   +  L+   G    F   L+ Y+  +K+ 
Sbjct: 186 DSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFT 245

Query: 561 NAARNDL 567
           +    DL
Sbjct: 246 SVVAQDL 252


>gi|188536004 zinc finger protein 469 [Homo sapiens]
          Length = 3925

 Score = 35.4 bits (80), Expect = 0.28
 Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 4/71 (5%)

Query: 62  SLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTS 121
           S  +    A+  P A G P     RG +   PGS      +G DSW P A   + PG   
Sbjct: 193 STNYTSPSATPRPPAPGPPQS---RGTSPLQPGSYPEYQASGADSWPPAAEN-SFPGANF 248

Query: 122 AQPPSEEEREP 132
             PP+E E  P
Sbjct: 249 GVPPAEPEPIP 259



 Score = 31.2 bits (69), Expect = 5.2
 Identities = 24/74 (32%), Positives = 31/74 (41%), Gaps = 4/74 (5%)

Query: 75   GADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVA-SPGTTSAQPPSEEEREPW 133
            G DG P+   E GG+   PG   R+  A G S   E G  A   G   A  PS   ++P 
Sbjct: 1119 GGDGAPANPEEPGGSRPGPG---RSPQARGPSRSLETGAAAREGGPKCADRPSVAPKDPL 1175

Query: 134  EPWTQLRLSGHLKP 147
            +  T    S   +P
Sbjct: 1176 QVPTNTETSEETRP 1189


>gi|21389407 hexamthylene bis-acetamide inducible 2 [Homo sapiens]
          Length = 286

 Score = 35.4 bits (80), Expect = 0.28
 Identities = 28/87 (32%), Positives = 36/87 (41%), Gaps = 21/87 (24%)

Query: 73  TPGADGGPSGFPER-GGNGSLPGSARRNHHA---------GGDSWQPEAGGVASPGTTSA 122
           T GA G P   PER    GSLP + R   H+         GG  W   +    SPG  SA
Sbjct: 23  TSGAPGSPQTPPERHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSPRTQSPGGCSA 82

Query: 123 QP----------PSEEEREPWEPWTQL 139
           +           PS+ +R  W P+ +L
Sbjct: 83  EAVLARKKHRRRPSKRKRH-WRPYLEL 108


>gi|4507347 TBP-associated factor 2 [Homo sapiens]
          Length = 1199

 Score = 35.4 bits (80), Expect = 0.28
 Identities = 43/199 (21%), Positives = 80/199 (40%), Gaps = 18/199 (9%)

Query: 276 FPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEED-GWVTDHFSQTPLMSTYYLAW 334
           FPC D      T+K+     A  +++SN  +  +V+  D    T H+  T   +   ++ 
Sbjct: 190 FPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISL 249

Query: 335 AICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYF--KVPYSLPK 392
           AI  F          V      +   + + +  Y LH    + EFYE+    + PYS  K
Sbjct: 250 AIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSY-LH---EVFEFYEEILTCRYPYSCFK 305

Query: 393 ---LDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGD 449
              +D   V    YA+M  +  ++     I+ +  ++           +   +  Q+FG 
Sbjct: 306 TVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTR--------RCLAQSLAQQFFGC 357

Query: 450 LVTPVWWEDVWLKEGFAHY 468
            ++ + W D W+ +G + Y
Sbjct: 358 FISRMSWSDEWVLKGISGY 376


>gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]
          Length = 1838

 Score = 35.0 bits (79), Expect = 0.36
 Identities = 23/63 (36%), Positives = 25/63 (39%), Gaps = 5/63 (7%)

Query: 69   GASATPGADG-----GPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQ 123
            G    PG DG     GP GFP   G    PG A ++   G      E G   SPG T   
Sbjct: 1324 GPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEP 1383

Query: 124  PPS 126
             PS
Sbjct: 1384 GPS 1386


>gi|116256354 alpha 2 type IV collagen preproprotein [Homo sapiens]
          Length = 1712

 Score = 35.0 bits (79), Expect = 0.36
 Identities = 23/65 (35%), Positives = 27/65 (41%), Gaps = 1/65 (1%)

Query: 69  GASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEE 128
           G S  PGADG P G P +GG    PG    N   G    Q   G     G    Q P  +
Sbjct: 109 GVSGFPGADGIP-GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQ 167

Query: 129 EREPW 133
           + EP+
Sbjct: 168 KGEPY 172


>gi|153267418 EDAR-associated death domain isoform A [Homo sapiens]
          Length = 215

 Score = 34.3 bits (77), Expect = 0.62
 Identities = 27/91 (29%), Positives = 39/91 (42%), Gaps = 8/91 (8%)

Query: 893 TCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYG 952
           +C ++    + LL     S+++ DQD +DVI       H     W+ F  KW      Y 
Sbjct: 95  SCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKW---GMSYD 151

Query: 953 EALFMNSKLISGVTEFL-----NTEGELKEL 978
           E  F+  +  S   EFL      T G+L EL
Sbjct: 152 ELCFLEQRPQSPTLEFLLRNSQRTVGQLMEL 182


>gi|18152769 EDAR-associated death domain isoform B [Homo sapiens]
          Length = 205

 Score = 34.3 bits (77), Expect = 0.62
 Identities = 27/91 (29%), Positives = 39/91 (42%), Gaps = 8/91 (8%)

Query: 893 TCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYG 952
           +C ++    + LL     S+++ DQD +DVI       H     W+ F  KW      Y 
Sbjct: 85  SCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKW---GMSYD 141

Query: 953 EALFMNSKLISGVTEFL-----NTEGELKEL 978
           E  F+  +  S   EFL      T G+L EL
Sbjct: 142 ELCFLEQRPQSPTLEFLLRNSQRTVGQLMEL 172


>gi|239756892 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 576

 Score = 33.9 bits (76), Expect = 0.81
 Identities = 18/50 (36%), Positives = 24/50 (48%)

Query: 75  GADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQP 124
           G  GG +   +R G  + PGS RR   AG  +  P  GG + P   +A P
Sbjct: 256 GPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPP 305


>gi|239751388 PREDICTED: hypothetical protein XP_002347834 [Homo
           sapiens]
          Length = 404

 Score = 33.9 bits (76), Expect = 0.81
 Identities = 18/50 (36%), Positives = 24/50 (48%)

Query: 75  GADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQP 124
           G  GG +   +R G  + PGS RR   AG  +  P  GG + P   +A P
Sbjct: 256 GPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPP 305


>gi|239745895 PREDICTED: hypothetical protein XP_002343612 [Homo
           sapiens]
          Length = 404

 Score = 33.9 bits (76), Expect = 0.81
 Identities = 18/50 (36%), Positives = 24/50 (48%)

Query: 75  GADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQP 124
           G  GG +   +R G  + PGS RR   AG  +  P  GG + P   +A P
Sbjct: 256 GPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPP 305


>gi|122937249 glutamate receptor interacting protein 2 [Homo
           sapiens]
          Length = 1141

 Score = 33.9 bits (76), Expect = 0.81
 Identities = 21/69 (30%), Positives = 27/69 (39%), Gaps = 1/69 (1%)

Query: 70  ASATPGADGGPSGF-PERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEE 128
           +SAT G  GGP  + P+    G+ P   R     G            +P       P EE
Sbjct: 887 SSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEE 946

Query: 129 EREPWEPWT 137
           E + WEP T
Sbjct: 947 EEDDWEPPT 955


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 33.1 bits (74), Expect = 1.4
 Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 1/58 (1%)

Query: 69   GASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPS 126
            G+   PG DG P G  +RG NGS PG+     H G       AG     G +    P+
Sbjct: 1017 GSDGLPGRDGSPGGKGDRGENGS-PGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPA 1073



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 21/70 (30%), Positives = 28/70 (40%), Gaps = 2/70 (2%)

Query: 67  ECGASATPGADGGPS--GFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQP 124
           E G+   PGA G P   G P   G+   PG    +   G D     AG   +PG+     
Sbjct: 862 ERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSG 921

Query: 125 PSEEEREPWE 134
           P  +  +P E
Sbjct: 922 PKGDAGQPGE 931



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 23/58 (39%), Positives = 26/58 (44%), Gaps = 9/58 (15%)

Query: 69  GASATPGADG-----GPSGFPERGGNGSLPGS--ARRNHHAGGDSWQPEAGGVASPGT 119
           G +  PG +G     GP G P   G   LPG+  AR N  A G   QP  G    PGT
Sbjct: 285 GENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQP--GPPGPPGT 340



 Score = 31.2 bits (69), Expect = 5.2
 Identities = 20/50 (40%), Positives = 23/50 (46%), Gaps = 1/50 (2%)

Query: 69  GASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPG 118
           GA+  PG DG P G   RG  GS PG    +   G    Q E+G    PG
Sbjct: 519 GAAGEPGRDGVPGGPGMRGMPGS-PGGPGSDGKPGPPGSQGESGRPGPPG 567



 Score = 30.4 bits (67), Expect = 8.9
 Identities = 22/67 (32%), Positives = 29/67 (43%), Gaps = 8/67 (11%)

Query: 69  GASATPGADG-----GPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASP--GTTS 121
           G   +PG  G     GP+GFP   G    PG  +    A G+  +    GVA P  G+  
Sbjct: 792 GPRGSPGERGETGPPGPAGFPGAPGQNGEPG-GKGERGAPGEKGEGGPPGVAGPPGGSGP 850

Query: 122 AQPPSEE 128
           A PP  +
Sbjct: 851 AGPPGPQ 857


>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
          Length = 1796

 Score = 32.7 bits (73), Expect = 1.8
 Identities = 23/68 (33%), Positives = 27/68 (39%), Gaps = 4/68 (5%)

Query: 67   ECGASATPGADG--GPSGFPERGGNGSLPGSARRNHHAG--GDSWQPEAGGVASPGTTSA 122
            E G   +PGA G  GP G P   GN  +PG+       G  G+   P  G     G    
Sbjct: 1658 EPGRPGSPGAPGEQGPPGTPGFPGNAGVPGTPGERGLTGIKGEKGNPGVGTQGPRGPPGP 1717

Query: 123  QPPSEEER 130
              PS E R
Sbjct: 1718 AGPSGESR 1725


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score = 32.3 bits (72), Expect = 2.3
 Identities = 20/67 (29%), Positives = 27/67 (40%)

Query: 64  RFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQ 123
           R D  G    PG   GP+G  E     + PG  R    +  +S Q E  G+ +      Q
Sbjct: 7   RRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQ 66

Query: 124 PPSEEER 130
           PP   +R
Sbjct: 67  PPQPLQR 73


>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
          Length = 1499

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 10/76 (13%)

Query: 67  ECGASATPGADGGPSGFPERGGNGS--------LPGSARRNHHAG--GDSWQPEAGGVAS 116
           E G + TPG  G   G  E+G  G+        LPG       AG  G+  +P   G+  
Sbjct: 766 ERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVG 825

Query: 117 PGTTSAQPPSEEEREP 132
           P  +   P S  E  P
Sbjct: 826 PPGSRGNPGSRGENGP 841


>gi|239744898 PREDICTED: hypothetical protein XP_002343297 [Homo
           sapiens]
          Length = 210

 Score = 32.0 bits (71), Expect = 3.1
 Identities = 38/130 (29%), Positives = 48/130 (36%), Gaps = 30/130 (23%)

Query: 11  GSRGLSDP--WAD--SVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTM---------- 56
           GSRG   P  WA   + G R    E H+    R  +A A      L V+           
Sbjct: 83  GSRGRRRPPSWARRRARGGRGSCPEPHVRAGPRFFIALAAPAARGLRVSSQGPGLWRGPA 142

Query: 57  ----------LAVLLSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDS 106
                     +A  L LR    G   TP   G P+ FP + G+        RNH A   +
Sbjct: 143 ARKEGVARVGVAAGLRLRPRGRGRKTTPALSGHPARFPLQPGDSR---ERSRNHRALELT 199

Query: 107 WQP---EAGG 113
           WQP   +AGG
Sbjct: 200 WQPRGAKAGG 209


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,108,081
Number of Sequences: 37866
Number of extensions: 1651718
Number of successful extensions: 6035
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 5584
Number of HSP's gapped (non-prelim): 390
length of query: 1024
length of database: 18,247,518
effective HSP length: 112
effective length of query: 912
effective length of database: 14,006,526
effective search space: 12773951712
effective search space used: 12773951712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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