BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo sapiens] (1024 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo ... 2085 0.0 gi|157266300 membrane alanine aminopeptidase precursor [Homo sap... 570 e-162 gi|132814467 glutamyl aminopeptidase [Homo sapiens] 504 e-142 gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 495 e-139 gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 495 e-139 gi|94818891 type 1 tumor necrosis factor receptor shedding amino... 478 e-134 gi|94818901 type 1 tumor necrosis factor receptor shedding amino... 478 e-134 gi|194239713 laeverin [Homo sapiens] 473 e-133 gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens] 460 e-129 gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens] 460 e-129 gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens] 390 e-108 gi|4505029 leukotriene A4 hydrolase [Homo sapiens] 85 3e-16 gi|40316915 arginyl aminopeptidase [Homo sapiens] 80 1e-14 gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Ho... 67 1e-10 gi|188536004 zinc finger protein 469 [Homo sapiens] 35 0.28 gi|21389407 hexamthylene bis-acetamide inducible 2 [Homo sapiens] 35 0.28 gi|4507347 TBP-associated factor 2 [Homo sapiens] 35 0.28 gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens] 35 0.36 gi|116256354 alpha 2 type IV collagen preproprotein [Homo sapiens] 35 0.36 gi|153267418 EDAR-associated death domain isoform A [Homo sapiens] 34 0.62 gi|18152769 EDAR-associated death domain isoform B [Homo sapiens] 34 0.62 gi|239756892 PREDICTED: hypothetical protein [Homo sapiens] 34 0.81 gi|239751388 PREDICTED: hypothetical protein XP_002347834 [Homo ... 34 0.81 gi|239745895 PREDICTED: hypothetical protein XP_002343612 [Homo ... 34 0.81 gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 34 0.81 gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens] 33 1.4 gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] 33 1.8 gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 32 2.3 gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens] 32 3.1 gi|239744898 PREDICTED: hypothetical protein XP_002343297 [Homo ... 32 3.1 >gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo sapiens] Length = 1024 Score = 2085 bits (5401), Expect = 0.0 Identities = 1024/1024 (100%), Positives = 1024/1024 (100%) Query: 1 MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVL 60 MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVL Sbjct: 1 MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVL 60 Query: 61 LSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTT 120 LSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTT Sbjct: 61 LSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTT 120 Query: 121 SAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYV 180 SAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYV Sbjct: 121 SAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYV 180 Query: 181 VLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNAL 240 VLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNAL Sbjct: 181 VLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNAL 240 Query: 241 IENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLS 300 IENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLS Sbjct: 241 IENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLS 300 Query: 301 LSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDA 360 LSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDA Sbjct: 301 LSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDA 360 Query: 361 IRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRIL 420 IRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRIL Sbjct: 361 IRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRIL 420 Query: 421 LDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPG 480 LDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPG Sbjct: 421 LDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPG 480 Query: 481 WNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANF 540 WNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANF Sbjct: 481 WNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANF 540 Query: 541 MGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVI 600 MGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVI Sbjct: 541 MGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVI 600 Query: 601 TILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIW 660 TILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIW Sbjct: 601 TILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIW 660 Query: 661 VSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGL 720 VSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGL Sbjct: 661 VSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGL 720 Query: 721 IDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEY 780 IDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEY Sbjct: 721 IDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEY 780 Query: 781 ILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDW 840 ILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDW Sbjct: 781 ILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDW 840 Query: 841 ISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNL 900 ISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNL Sbjct: 841 ISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNL 900 Query: 901 LNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK 960 LNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK Sbjct: 901 LNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK 960 Query: 961 LISGVTEFLNTEGELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGK 1020 LISGVTEFLNTEGELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGK Sbjct: 961 LISGVTEFLNTEGELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGK 1020 Query: 1021 ALRH 1024 ALRH Sbjct: 1021 ALRH 1024 >gi|157266300 membrane alanine aminopeptidase precursor [Homo sapiens] Length = 967 Score = 570 bits (1468), Expect = e-162 Identities = 331/946 (34%), Positives = 495/946 (52%), Gaps = 41/946 (4%) Query: 95 SARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLML 154 S +N +A P A S T+ P S + + W + RL LKP Y + L Sbjct: 34 SQEKNKNANSS---PVASTTPSASATT-NPASATTLDQSKAWNRYRLPNTLKPDSYRVTL 89 Query: 155 TAFMEN-----FTFSGEVNVEIACRNATRYVVLHASRVAVEKVQ---LAEDRAFGAVP-- 204 ++ + F G V C+ AT +++H+ ++ Q + G+ P Sbjct: 90 RPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPD 149 Query: 205 VAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGERRFLGV 264 + L T+ LVV L +L Y + + + ++L GF+RS Y+ R+ + Sbjct: 150 IDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVAT 209 Query: 265 TQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVE---TSVFEEDGWVTDHF 321 TQ ARK+FPCFDEP KA F I++ H +LSNM + T + E+ W F Sbjct: 210 TQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEF 269 Query: 322 SQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYE 381 TP MSTY LA+ + F Y E +GV++R++ARP AI G GDYAL++T ++ F+ Sbjct: 270 HTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFA 329 Query: 382 DYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 441 ++ PY LPK D + +P AMENWGL + E +L DP SS S V VI HE Sbjct: 330 GHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHE 389 Query: 442 ICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDG 501 + HQWFG+LVT WW D+WL EGFA Y E++G DY P WN++ L DV + VM +D Sbjct: 390 LAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDV-YRVMAVDA 448 Query: 502 LASSHPVS---QEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHK 558 LASSHP+S E+ I +FD I+Y KGA+++RML++F+ VF++GL YL Sbjct: 449 LASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFA 508 Query: 559 YGNAARNDLWNTLSEALKRNGKYV--NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQ 616 Y N +LW+ L EA+ + ++++M++WTLQMG+PVIT+ +T ++Q Sbjct: 509 YQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGT-----LSQ 563 Query: 617 QHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKG 676 +HF+ D + + +Y+W +P+T + R + W+ + + + Sbjct: 564 EHFLLD--PDSNVTRPSEFNYVWIVPITSIRDGR----QQQDYWLIDVRAQNDLFSTSGN 617 Query: 677 SWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQN 736 W+L N+N TGY+RVNYD NWR + QL R+H + V NRA +I+DAF+LA A +P Sbjct: 618 EWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVT 677 Query: 737 IPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPK 796 + L +L EE+ ++PW AA +L + DR E Y Y+ KQV +I Sbjct: 678 LALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNT 737 Query: 797 NNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISS-NRNRIPLNVRDI 855 NN+ Q+ E+ I ACS G C + S L W+ + N N I N+R Sbjct: 738 NNWREIPENLMDQYSEV--NAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRST 795 Query: 856 VYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVL 915 VYC ++ E+ W+F W +F + T V+E L AL CS + +LNR L+ +LN +++ Sbjct: 796 VYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIR 855 Query: 916 DQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGEL 975 QDA II + N G+ L W F + WK L YG F S LI VT +TE EL Sbjct: 856 KQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYEL 915 Query: 976 KELKNFMKNYD----GVAAASFSRAVETVEANVRWKMLYQDELFQW 1017 ++L+ F K+ + G + +A+E +AN++W ++ + QW Sbjct: 916 QQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQW 961 >gi|132814467 glutamyl aminopeptidase [Homo sapiens] Length = 957 Score = 504 bits (1297), Expect = e-142 Identities = 329/1004 (32%), Positives = 508/1004 (50%), Gaps = 79/1004 (7%) Query: 30 TERHIAVHKRLVLAFAVSLVALLAVTMLAVLLSLRFDECGASATPGADGGPSGFPERGGN 89 ++R+ K + + AV +V + + LAV L+ D G DGGP P Sbjct: 9 SKRYCIQTKHVAILCAV-VVGVGLIVGLAVGLTRSCDSSG-------DGGPGTAP---AP 57 Query: 90 GSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQ-----PPSEEEREPWEPWTQLRLSGH 144 LP S ASP AQ P SE+E W+ RL Sbjct: 58 SHLPSST------------------ASPSGPPAQDQDICPASEDESGQWK---NFRLPDF 96 Query: 145 LKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAEDRAFGAVP 204 + P+HY+L + +E T++G V++ I TRY+ LH + ++ + + V Sbjct: 97 VNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQ 156 Query: 205 VAGFFLYPQTQVLVVVLNRTLDAQRN---YNLKIIYNALIENELLGFFRSSYVLHGERRF 261 V F Y + + +VV L Y L + + + L+GF+R++Y +G+ + Sbjct: 157 VRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKS 216 Query: 262 LGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHF 321 + T PT ARK+FPCFDEP KAT+ ISI H Y +LSNMPV +D W F Sbjct: 217 IVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTF 276 Query: 322 SQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYE 381 ++ MSTY + +A+ F + + SG + +Y +P+ ++ + +YA +ITK + +++E Sbjct: 277 EKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPE--QKHTAEYAANITKSVFDYFE 334 Query: 382 DYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 441 +YF + YSLPKLD +A+P AMENWGL + E +L DP S+ S V V+ HE Sbjct: 335 EYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHE 394 Query: 442 ICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDG 501 + HQWFG++VT WWED+WL EGFA +FEF+G ++ W M Q L DVL V D Sbjct: 395 LVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVL-PVQEDDS 453 Query: 502 LASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGN 561 L SSHP+ V +I VFD I+Y KG++++RML +++ FQ+G Q YL +++ N Sbjct: 454 LMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKN 513 Query: 562 AARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIY 621 A +D W L EA + + ++EVMD WT QMGYPV+ + G ITQ+ F+ Sbjct: 514 AKTSDFWAALEEASR-----LPVKEVMDTWTRQMGYPVLNVNGVKN------ITQKRFLL 562 Query: 622 DISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDK----GS 677 D A + + Y W IP V +++S + N+SE IT + Sbjct: 563 DPRA-NPSQPPSDLGYTWNIP---VKWTEDNITSSVLF---NRSEKEGITLNSSNPSGNA 615 Query: 678 WLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNI 737 +L N + G++RVNY++ W + L NH+ S ++RA LIDDAF+LARA L + Sbjct: 616 FLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKV 675 Query: 738 PLEIIRYLSEEKDFLPW-HAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPK 796 L + +YL E++FLPW S Y + D E Y + EY QV LGW Sbjct: 676 ALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGW-- 733 Query: 797 NNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIV 856 N G V + LR V+ AC G++ AS+L W++ + +P+N+R +V Sbjct: 734 -NDAGDHVT-----KLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVS-LPVNLRLLV 786 Query: 857 YCTGVSLLDEDV-WEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVL 915 Y G+ ++ W + ++ T+ EK+ LL L + LL+R L+L ++ ++ Sbjct: 787 YRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIK 846 Query: 916 DQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGEL 975 QD VI +++ N +G+++AW + + W L RY N I + E NTE +L Sbjct: 847 TQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRY-TLNNRNLGRIVTIAEPFNTELQL 905 Query: 976 KELKNFMKNYDGVAAASFSR--AVETVEANVRWKMLYQDELFQW 1017 ++++F Y A R +ETV+ N+ W +++ + +W Sbjct: 906 WQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949 >gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] Length = 960 Score = 495 bits (1274), Expect = e-139 Identities = 299/914 (32%), Positives = 467/914 (51%), Gaps = 50/914 (5%) Query: 135 PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194 PW +LRL + PLHY+L + + + F +E+ NAT++++LH+ + + L Sbjct: 63 PWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATL 122 Query: 195 AED---RAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRS 251 + R YP + + +++ L Y + + + A + + GF++S Sbjct: 123 QSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKS 182 Query: 252 SY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSV 310 +Y L GE R L VT F PT AR AFPCFDEP++KA F I I+ ++ +++LSNMP ++ Sbjct: 183 TYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTI 242 Query: 311 FEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYAL 370 E G + DHF T MSTY +A+ +C+F T SGV V +YA PD +R YAL Sbjct: 243 ELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPD--KRNQTHYAL 300 Query: 371 HITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISY 430 + +L++FYE YF + Y L KLDL+A+P AMENWGL + E +L DP SS S Sbjct: 301 QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360 Query: 431 LLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLT 490 L VT VI HE+ HQWFG+LVT WW D+WLKEGFA Y E + + YP ++ + Sbjct: 361 KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYP--ELQFDDYFL 418 Query: 491 DVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGL 550 +V EV+ D L SS P+S+ T I +FD ++Y KGA ++ ML +F+G FQ+G+ Sbjct: 419 NVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGI 478 Query: 551 QDYLTIHKYGNAARNDLWNTLSEALKRN----------------------GKYVNIQEVM 588 YL Y NA +DLW++LS + + G+ ++E+M Sbjct: 479 IQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMM 538 Query: 589 DQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVG 648 WTLQ G P++ + + + + + Q+ F+ + + + YLW IPLT Sbjct: 539 TTWTLQKGIPLLVVKQDGCS---LRLQQERFLQGVFQEDPEWRALQERYLWHIPLTY--- 592 Query: 649 NRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRN 708 S SS I KS+ + +K SW+ N++ GY+ V+Y+ W LI QL +N Sbjct: 593 --STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650 Query: 709 HEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLL 768 H +L +R GLI D F L AG L + L++ YL E A L L+ Sbjct: 651 HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLESFY 707 Query: 769 DRMENYNIFN-EYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNK 827 M+ NI + LK+ Y K + +++ + S LR ++ LAC + Sbjct: 708 HMMDRRNISDISENLKRYLLQYFKPVIDRQSWSD---KGSVWDRMLRSALLKLACDLNHA 764 Query: 828 HCHQQASTLISDWI-SSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKK 886 C Q+A+ L S W+ SS + IP +V IVY G W ++ ++ + + +E+ Sbjct: 765 PCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAG--WNYLLEQYELSMSSAEQN 822 Query: 887 ILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKI 946 +L AL+ S + L +L+ L + +V+ Q+ ++ +AR P G+ LAW F R+ W Sbjct: 823 KILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTH 882 Query: 947 LNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYD--GVAAASFSRAVETVEANV 1004 L ++ + +ISG T +++ +L+E+K F ++ + G F +ET+ N+ Sbjct: 883 LLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNI 942 Query: 1005 RWKMLYQDELFQWL 1018 +W L WL Sbjct: 943 KWLEKNLPTLRTWL 956 >gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] Length = 960 Score = 495 bits (1274), Expect = e-139 Identities = 299/914 (32%), Positives = 467/914 (51%), Gaps = 50/914 (5%) Query: 135 PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194 PW +LRL + PLHY+L + + + F +E+ NAT++++LH+ + + L Sbjct: 63 PWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATL 122 Query: 195 AED---RAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRS 251 + R YP + + +++ L Y + + + A + + GF++S Sbjct: 123 QSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKS 182 Query: 252 SY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSV 310 +Y L GE R L VT F PT AR AFPCFDEP++KA F I I+ ++ +++LSNMP ++ Sbjct: 183 TYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTI 242 Query: 311 FEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYAL 370 E G + DHF T MSTY +A+ +C+F T SGV V +YA PD +R YAL Sbjct: 243 ELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPD--KRNQTHYAL 300 Query: 371 HITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISY 430 + +L++FYE YF + Y L KLDL+A+P AMENWGL + E +L DP SS S Sbjct: 301 QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360 Query: 431 LLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLT 490 L VT VI HE+ HQWFG+LVT WW D+WLKEGFA Y E + + YP ++ + Sbjct: 361 KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYP--ELQFDDYFL 418 Query: 491 DVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGL 550 +V EV+ D L SS P+S+ T I +FD ++Y KGA ++ ML +F+G FQ+G+ Sbjct: 419 NVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGI 478 Query: 551 QDYLTIHKYGNAARNDLWNTLSEALKRN----------------------GKYVNIQEVM 588 YL Y NA +DLW++LS + + G+ ++E+M Sbjct: 479 IQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMM 538 Query: 589 DQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVG 648 WTLQ G P++ + + + + + Q+ F+ + + + YLW IPLT Sbjct: 539 TTWTLQKGIPLLVVKQDGCS---LRLQQERFLQGVFQEDPEWRALQERYLWHIPLTY--- 592 Query: 649 NRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRN 708 S SS I KS+ + +K SW+ N++ GY+ V+Y+ W LI QL +N Sbjct: 593 --STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650 Query: 709 HEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLL 768 H +L +R GLI D F L AG L + L++ YL E A L L+ Sbjct: 651 HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLESFY 707 Query: 769 DRMENYNIFN-EYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNK 827 M+ NI + LK+ Y K + +++ + S LR ++ LAC + Sbjct: 708 HMMDRRNISDISENLKRYLLQYFKPVIDRQSWSD---KGSVWDRMLRSALLKLACDLNHA 764 Query: 828 HCHQQASTLISDWI-SSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKK 886 C Q+A+ L S W+ SS + IP +V IVY G W ++ ++ + + +E+ Sbjct: 765 PCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAG--WNYLLEQYELSMSSAEQN 822 Query: 887 ILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKI 946 +L AL+ S + L +L+ L + +V+ Q+ ++ +AR P G+ LAW F R+ W Sbjct: 823 KILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTH 882 Query: 947 LNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYD--GVAAASFSRAVETVEANV 1004 L ++ + +ISG T +++ +L+E+K F ++ + G F +ET+ N+ Sbjct: 883 LLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNI 942 Query: 1005 RWKMLYQDELFQWL 1018 +W L WL Sbjct: 943 KWLEKNLPTLRTWL 956 >gi|94818891 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator isoform b [Homo sapiens] Length = 941 Score = 478 bits (1230), Expect = e-134 Identities = 285/925 (30%), Positives = 456/925 (49%), Gaps = 61/925 (6%) Query: 125 PSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHA 184 P + P+ PW ++RL ++ P+HY+L++ A + TF G VEI T ++LH+ Sbjct: 39 PKRSDGTPF-PWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHS 97 Query: 185 SRVAVEKVQLAEDRA--FGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIE 242 + + + L + P+ +P+ + + ++ L Y + I Y + Sbjct: 98 HHLQISRATLRKGAGERLSEEPLQ-VLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLS 156 Query: 243 NELLGFFRSSY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSL 301 GF++S+Y GE R L TQF PT AR AFPCFDEP +KA+F I I+ + +L++ Sbjct: 157 ETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAI 216 Query: 302 SNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAI 361 SNMP+ SV +G + DHF T MSTY +A+ I +F TKSGV V +YA PD I Sbjct: 217 SNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKI 276 Query: 362 RRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILL 421 + DYAL L+EFYEDYF +PY LPK DL A+P AMENWGL+ + E +L Sbjct: 277 NQA--DYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLF 334 Query: 422 DPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGW 481 D SS S L +TM + HE+ HQWFG+LVT WW D+WL EGFA + EFV +P Sbjct: 335 DAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHP-- 392 Query: 482 NMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFM 541 ++ + + M +D L SSHPVS V I +FD ++Y KGA ++ ML ++ Sbjct: 393 ELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYL 452 Query: 542 GHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNG---------------------- 579 F+ G+ YL H Y N DLW++++ +G Sbjct: 453 SADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQ 512 Query: 580 KYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLW 639 + V+++ +M+ WTLQ G+P+ITI T + + Q+H++ + YLW Sbjct: 513 EGVDVKTMMNTWTLQKGFPLITI---TVRGRNVHMKQEHYMKGSDG------APDTGYLW 563 Query: 640 QIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWR 699 +PLT + V + K++ + ++ W+ N+ GY+ V+Y+ W Sbjct: 564 HVPLTFITSKSDMVHRFLL-----KTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWD 618 Query: 700 LLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASR 759 L L H +S ++RA LI++AF L G L L++ YL E + +P Sbjct: 619 SLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLN 678 Query: 760 ALYPLDKLLDRMENYNI---FNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRRE 816 L P+ KL+++ + + F ++++ + K W + S LR + Sbjct: 679 ELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTD--------EGSVSERMLRSQ 730 Query: 817 VIMLACSFGNKHCHQQASTLISDWISSNRN-RIPLNVRDIVYCTGVSLLDEDVWEFIWMK 875 +++LAC + C Q+A W SN N +P++V V+ G + W+F++ K Sbjct: 731 LLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQ--STEGWDFLYSK 788 Query: 876 FHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDL 935 + + + +EK + AL + ++ L LL+ S + + Q+ ++ + RNP G L Sbjct: 789 YQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPL 848 Query: 936 AWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNY--DGVAAASF 993 AW+F R W L ++ + ++ G T +T L+E+K F + +G Sbjct: 849 AWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCV 908 Query: 994 SRAVETVEANVRWKMLYQDELFQWL 1018 + +ET+E N+ W D++ WL Sbjct: 909 QQTIETIEENIGWMDKNFDKIRVWL 933 >gi|94818901 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator isoform a [Homo sapiens] Length = 948 Score = 478 bits (1230), Expect = e-134 Identities = 285/925 (30%), Positives = 456/925 (49%), Gaps = 61/925 (6%) Query: 125 PSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHA 184 P + P+ PW ++RL ++ P+HY+L++ A + TF G VEI T ++LH+ Sbjct: 39 PKRSDGTPF-PWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHS 97 Query: 185 SRVAVEKVQLAEDRA--FGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIE 242 + + + L + P+ +P+ + + ++ L Y + I Y + Sbjct: 98 HHLQISRATLRKGAGERLSEEPLQ-VLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLS 156 Query: 243 NELLGFFRSSY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSL 301 GF++S+Y GE R L TQF PT AR AFPCFDEP +KA+F I I+ + +L++ Sbjct: 157 ETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAI 216 Query: 302 SNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAI 361 SNMP+ SV +G + DHF T MSTY +A+ I +F TKSGV V +YA PD I Sbjct: 217 SNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKI 276 Query: 362 RRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILL 421 + DYAL L+EFYEDYF +PY LPK DL A+P AMENWGL+ + E +L Sbjct: 277 NQA--DYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLF 334 Query: 422 DPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGW 481 D SS S L +TM + HE+ HQWFG+LVT WW D+WL EGFA + EFV +P Sbjct: 335 DAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHP-- 392 Query: 482 NMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFM 541 ++ + + M +D L SSHPVS V I +FD ++Y KGA ++ ML ++ Sbjct: 393 ELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYL 452 Query: 542 GHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNG---------------------- 579 F+ G+ YL H Y N DLW++++ +G Sbjct: 453 SADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQ 512 Query: 580 KYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLW 639 + V+++ +M+ WTLQ G+P+ITI T + + Q+H++ + YLW Sbjct: 513 EGVDVKTMMNTWTLQKGFPLITI---TVRGRNVHMKQEHYMKGSDG------APDTGYLW 563 Query: 640 QIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWR 699 +PLT + V + K++ + ++ W+ N+ GY+ V+Y+ W Sbjct: 564 HVPLTFITSKSDMVHRFLL-----KTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWD 618 Query: 700 LLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASR 759 L L H +S ++RA LI++AF L G L L++ YL E + +P Sbjct: 619 SLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLN 678 Query: 760 ALYPLDKLLDRMENYNI---FNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRRE 816 L P+ KL+++ + + F ++++ + K W + S LR + Sbjct: 679 ELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTD--------EGSVSERMLRSQ 730 Query: 817 VIMLACSFGNKHCHQQASTLISDWISSNRN-RIPLNVRDIVYCTGVSLLDEDVWEFIWMK 875 +++LAC + C Q+A W SN N +P++V V+ G + W+F++ K Sbjct: 731 LLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQ--STEGWDFLYSK 788 Query: 876 FHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDL 935 + + + +EK + AL + ++ L LL+ S + + Q+ ++ + RNP G L Sbjct: 789 YQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPL 848 Query: 936 AWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNY--DGVAAASF 993 AW+F R W L ++ + ++ G T +T L+E+K F + +G Sbjct: 849 AWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCV 908 Query: 994 SRAVETVEANVRWKMLYQDELFQWL 1018 + +ET+E N+ W D++ WL Sbjct: 909 QQTIETIEENIGWMDKNFDKIRVWL 933 >gi|194239713 laeverin [Homo sapiens] Length = 990 Score = 473 bits (1216), Expect = e-133 Identities = 290/884 (32%), Positives = 466/884 (52%), Gaps = 52/884 (5%) Query: 132 PWEPWTQLRLSGHLKPLHYNLMLTAFME-------NFTFSGEVNVEIACRNATRYVVLHA 184 P PW QLRL L PLHY+L L + + F+G VN+ + C AT ++LH+ Sbjct: 89 PPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHS 148 Query: 185 SRVAVEKVQL-------AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIY 237 E+ ++ + G VPV + T+ +V+ L+ L +Y L++ + Sbjct: 149 LFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSF 208 Query: 238 NALIENELL-GFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA 296 + L++ +L G F + Y GERR L +Q PT AR FPCFDEP KATF I++ H Sbjct: 209 SGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHP 268 Query: 297 TYLSLSNMPVETSVFEED----GWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVV 352 +Y++LSNMP +ED W FS TP M TY +A+ IC++ + T + G + Sbjct: 269 SYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTER-GKEI 327 Query: 353 RLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLS 412 R++AR DAI GS D+AL+IT + F ED F + YSLPK D++A+P AMENWGL Sbjct: 328 RIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLM 387 Query: 413 IFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFV 472 IF E +LL+P ++ V+ HEI HQWFG+LVT WW ++WL EGFA YFEF Sbjct: 388 IFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFE 447 Query: 473 GTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEV--LQATDIDRVFDWIAYKKG 530 +Y P + F +++LH ++ D + V+ +V + ++I +FD Y KG Sbjct: 448 VINYFNPKL-PRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKG 506 Query: 531 AALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV---NIQEV 587 A++ RML+ F+ +F L+ YL Y NA ++DLW A+ + I+ + Sbjct: 507 ASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNI 566 Query: 588 MDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVV 647 MD WT Q G+PVIT+ +T + +Q Y + K + L N++ W +P+ + Sbjct: 567 MDSWTHQSGFPVITLNVSTG------VMKQEPFYLENIKNRTLLTSNDT--WIVPILWI- 617 Query: 648 GNRSHVSSEAIIWVSNKSE---HHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQ 704 + +++ ++W+ S+ +++ D W++ N+N TGY+RVNYD W+ L Q Sbjct: 618 ---KNGTTQPLVWLDQSSKVFPEMQVSDSDH-DWVILNLNMTGYYRVNYDKLGWKKLNQQ 673 Query: 705 LIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPL 764 L ++ + + V +R LIDDAFSL++ Y+ LE+ +YL+EE + + WH L Sbjct: 674 LEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTR 733 Query: 765 DKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNF----NGSLVQASYQHEELRREVIML 820 D L+ + Y+I++ +LK+ + L W + N +Q Y ++ + Sbjct: 734 D-LVSEVNIYDIYS--LLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLALISLEKLFVT 790 Query: 821 ACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTT 880 AC G + C Q + L + W+ N IP ++D+V C G++L + W+ + + +TT Sbjct: 791 ACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTT 850 Query: 881 AVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFF 940 EK L A++CS D +LNR + ++++ + ++I VA + GR +A F Sbjct: 851 NKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNET-NIIEVVASSEVGRYVAKDFL 909 Query: 941 RDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKN 984 + W+ ++ RYG +N LI + + T+ ++ EL+ F N Sbjct: 910 VNNWQAVSKRYGTQSLIN--LIYTIGRTVTTDLQIVELQQFFSN 951 >gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens] Length = 1025 Score = 460 bits (1184), Expect = e-129 Identities = 284/888 (31%), Positives = 449/888 (50%), Gaps = 28/888 (3%) Query: 135 PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194 PW Q+RL + PL Y L L + + TF G V + + T ++LH++ + +V Sbjct: 162 PWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTF 221 Query: 195 AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYV 254 A Y + +V L A NY LKI Y+A I + GF+ SY Sbjct: 222 MS-AVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYT 280 Query: 255 LHG-ERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEE 313 E+++ TQF P AR AFPCFDEP +KATF I I Y +LSNMP ++SV + Sbjct: 281 DESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLD 340 Query: 314 DGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHIT 373 DG V D FS++ MSTY +A+ + +G +V +YA P+ I G YAL T Sbjct: 341 DGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKI--GQVHYALETT 397 Query: 374 KRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD 433 +L+EF+++YF++ Y L KLDL+A+P AMENWGL F E+ +L D + SS++ Sbjct: 398 VKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKL 457 Query: 434 VTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVL 493 VT +I HE+ HQWFG+LVT WW D+WL EGFA + E+ + ++ + D Sbjct: 458 VTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFK--ELSSYEDFLDAR 515 Query: 494 HEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDY 553 + M D L SSHP+S V + I+ +FD ++Y KG++L+ ML ++ VFQ + Y Sbjct: 516 FKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLY 575 Query: 554 LTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRII 613 L H Y + +DLW++ +E + ++++ +M WTLQ G+P++T+ + Sbjct: 576 LHNHSYASIQSDDLWDSFNEVTNQT---LDVKRMMKTWTLQKGFPLVTV---QKKGKELF 629 Query: 614 ITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYL 673 I Q+ F ++ + ++ + SYLW IPL+ V R++ +++ + KS +T Sbjct: 630 IQQERFFLNMKPE---IQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLT-- 684 Query: 674 DKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYL 733 ++ W+ NIN GY+ V+Y +W LI QL N VLS +RA LI++ F LA G + Sbjct: 685 EEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKV 744 Query: 734 PQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLG 793 P ++I YL E P + AL+ D + + +E + + ++ T KL Sbjct: 745 PLKRAFDLINYLGNENHTAP---ITEALFQTDLIYNLLEKLGYMD--LASRLVTRVFKLL 799 Query: 794 WPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNR-IPLNV 852 + + + ELR ++ AC+ +C A L DW++SN + +P +V Sbjct: 800 QNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDV 859 Query: 853 RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSE 912 V+ G + W F+ K+ S + +EK +LEAL S+D L L+ SLN + Sbjct: 860 MTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGD 917 Query: 913 VVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTE 972 Q +I V R+ G LAW F ++ W L ++ + +++G T +T+ Sbjct: 918 NFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTK 977 Query: 973 GELKELKNFMKNYDGVA--AASFSRAVETVEANVRWKMLYQDELFQWL 1018 L E++ F +N A+E ++ N++W L WL Sbjct: 978 THLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1025 >gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens] Length = 1011 Score = 460 bits (1184), Expect = e-129 Identities = 284/888 (31%), Positives = 449/888 (50%), Gaps = 28/888 (3%) Query: 135 PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194 PW Q+RL + PL Y L L + + TF G V + + T ++LH++ + +V Sbjct: 148 PWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTF 207 Query: 195 AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYV 254 A Y + +V L A NY LKI Y+A I + GF+ SY Sbjct: 208 MS-AVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYT 266 Query: 255 LHG-ERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEE 313 E+++ TQF P AR AFPCFDEP +KATF I I Y +LSNMP ++SV + Sbjct: 267 DESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLD 326 Query: 314 DGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHIT 373 DG V D FS++ MSTY +A+ + +G +V +YA P+ I G YAL T Sbjct: 327 DGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKI--GQVHYALETT 383 Query: 374 KRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD 433 +L+EF+++YF++ Y L KLDL+A+P AMENWGL F E+ +L D + SS++ Sbjct: 384 VKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKL 443 Query: 434 VTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVL 493 VT +I HE+ HQWFG+LVT WW D+WL EGFA + E+ + ++ + D Sbjct: 444 VTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFK--ELSSYEDFLDAR 501 Query: 494 HEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDY 553 + M D L SSHP+S V + I+ +FD ++Y KG++L+ ML ++ VFQ + Y Sbjct: 502 FKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLY 561 Query: 554 LTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRII 613 L H Y + +DLW++ +E + ++++ +M WTLQ G+P++T+ + Sbjct: 562 LHNHSYASIQSDDLWDSFNEVTNQT---LDVKRMMKTWTLQKGFPLVTV---QKKGKELF 615 Query: 614 ITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYL 673 I Q+ F ++ + ++ + SYLW IPL+ V R++ +++ + KS +T Sbjct: 616 IQQERFFLNMKPE---IQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLT-- 670 Query: 674 DKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYL 733 ++ W+ NIN GY+ V+Y +W LI QL N VLS +RA LI++ F LA G + Sbjct: 671 EEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKV 730 Query: 734 PQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLG 793 P ++I YL E P + AL+ D + + +E + + ++ T KL Sbjct: 731 PLKRAFDLINYLGNENHTAP---ITEALFQTDLIYNLLEKLGYMD--LASRLVTRVFKLL 785 Query: 794 WPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNR-IPLNV 852 + + + ELR ++ AC+ +C A L DW++SN + +P +V Sbjct: 786 QNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDV 845 Query: 853 RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSE 912 V+ G + W F+ K+ S + +EK +LEAL S+D L L+ SLN + Sbjct: 846 MTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGD 903 Query: 913 VVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTE 972 Q +I V R+ G LAW F ++ W L ++ + +++G T +T+ Sbjct: 904 NFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTK 963 Query: 973 GELKELKNFMKNYDGVA--AASFSRAVETVEANVRWKMLYQDELFQWL 1018 L E++ F +N A+E ++ N++W L WL Sbjct: 964 THLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1011 >gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens] Length = 919 Score = 390 bits (1003), Expect = e-108 Identities = 275/899 (30%), Positives = 451/899 (50%), Gaps = 45/899 (5%) Query: 129 EREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVA 188 E+ P+E RL + P++Y+L L + +FTF G++ R AT +V++ + + Sbjct: 47 EKRPFE-----RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADID 101 Query: 189 VEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGF 248 + A + + GF + + + + TL LKI + + +++ GF Sbjct: 102 IITASYAPE-GDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGF 159 Query: 249 FRSSYVL-HGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV- 306 +RS Y GE R+ VTQF T AR+AFPC+DEP KATF IS+ ++LSNM V Sbjct: 160 YRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVI 219 Query: 307 -ETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGS 365 +++ V F++TP+MSTY +A+ + + + ET +K GV VR+Y +G Sbjct: 220 DRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 279 Query: 366 GDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSV 425 +AL + + + FY+DYF VPY LPK+DL+A+ AMENWGL + E +L+DP Sbjct: 280 --FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKN 337 Query: 426 SSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEK 485 S S V +V+ HE+ HQWFG+LVT WW +WL EGFA + E++ D+ +P +++ Sbjct: 338 SCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWT 397 Query: 486 QRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSV 545 Q F++ LD L +SHP+ V +++D +FD I+Y KGA++IRML +++G Sbjct: 398 Q-FVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKD 456 Query: 546 FQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGN 605 F++G+ YLT + NAA DLW +L A +GK I VM+ WT QMG+P+I + Sbjct: 457 FKKGMNMYLTKFQQKNAATEDLWESLENA---SGK--PIAAVMNTWTKQMGFPLIYVEAE 511 Query: 606 TTAENRII-ITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNK 664 ++R++ ++Q+ F S + + W +P+TI + + I+ + Sbjct: 512 QVEDDRLLRLSQKKFCAGGS------YVGEDCPQWMVPITISTSEDPNQAKLKIL-MDKP 564 Query: 665 SEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVS--NRAGLID 722 + + + W+ N+ G++R Y +++ L+ LS+ +R GL + Sbjct: 565 EMNVVLKNVKPDQWVKLNLGTVGFYRTQYS----SAMLESLLPGIRDLSLPPVDRLGLQN 620 Query: 723 DAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYIL 782 D FSLARAG + L+++ E ++ W S L L LL + Y E++ Sbjct: 621 DLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVK 680 Query: 783 KQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWIS 842 + +LGW G L LR V+ G+K ++A D + Sbjct: 681 DVFSPIGERLGWDPKPGEGHL------DALLRGLVLGKLGKAGHKATLEEARRRFKDHV- 733 Query: 843 SNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLE-ALTCSDDRNLL 901 + + ++R VY T + D + I +K H + E+K +E L + +L+ Sbjct: 734 EGKQILSADLRSPVYLTVLKHGDGTTLD-IMLKLHKQADMQEEKNRIERVLGATLLPDLI 792 Query: 902 NRLLNLSLNSEVVLDQDAIDVIIHVA-RNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK 960 ++L +L SE V QD + VI VA + HGR AWKF +D W+ L RY + F+ S+ Sbjct: 793 QKVLTFAL-SEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRY-QGGFLISR 850 Query: 961 LISGVTEFLNTEGELKELKNFMKNYDGVAA-ASFSRAVETVEANVRWKMLYQDELFQWL 1018 LI E + E+K F +++ +A + + E + N W + + Q+L Sbjct: 851 LIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYL 909 >gi|4505029 leukotriene A4 hydrolase [Homo sapiens] Length = 611 Score = 85.1 bits (209), Expect = 3e-16 Identities = 93/372 (25%), Positives = 147/372 (39%), Gaps = 44/372 (11%) Query: 265 TQFSPTHARKAFPCFDEPIYKATF--KISIKHQATYLSLSNMPVETSVFEEDGWVTDHFS 322 +Q H R PC D P K T+ ++S+ + L + ET E+ F Sbjct: 134 SQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFI 193 Query: 323 QTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYED 382 Q + Y +A + R+ ++ V ++ + + + + Y T+ +++ ED Sbjct: 194 QKVPIPCYLIALVVGALESRQIGPRTLV----WSEKEQVEKSA--YEFSETESMLKIAED 247 Query: 383 YFKVPYSLPKLDLLAVP-KHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 441 PY + DLL +P PY MEN L+ + D S+S+ VI HE Sbjct: 248 -LGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSN---------VIAHE 297 Query: 442 ICHQWFGDLVTPVWWEDVWLKEGFAHYFE------FVGTDYLY----PGWNMEKQRFLTD 491 I H W G+LVT W+ WL EG Y E G + + GW + T Sbjct: 298 ISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKT- 356 Query: 492 VLHEVMLLDGLASSHPVSQEVLQATDIDR--VFDWIAYKKGAALIRMLANFM-GHSVFQR 548 +HP ++ V+ TDID + + Y+KG AL+ L + G +F Sbjct: 357 ----------FGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLG 406 Query: 549 GLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTA 608 L+ Y+ Y + +D + L K +N Q + W G P I + T Sbjct: 407 FLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLN-QVDWNAWLYSPGLPPIKPNYDMTL 465 Query: 609 ENRIIITQQHFI 620 N I Q +I Sbjct: 466 TNACIALSQRWI 477 >gi|40316915 arginyl aminopeptidase [Homo sapiens] Length = 650 Score = 79.7 bits (195), Expect = 1e-14 Identities = 86/351 (24%), Positives = 147/351 (41%), Gaps = 30/351 (8%) Query: 257 GERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGW 316 G+++ TQ R FPCFD P K + I+ + ++ + S +E+ G Sbjct: 160 GKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAV----MSASTWEKRGP 215 Query: 317 VTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRL 376 F + +Y +A AI + E +S R++A P I +Y + + Sbjct: 216 NKFFFQMCQPIPSYLIALAIGDLVSAEVGPRS----RVWAEPCLIDAAKEEYN-GVIEEF 270 Query: 377 IEFYEDYFKVPYSLPKLDLLAVP-KHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVT 435 + E F PY + DLL +P P+ MEN L+ + D S++ Sbjct: 271 LATGEKLFG-PYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLAD-------- 321 Query: 436 MVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFE-FVGTDYLYPGWNMEKQRFLTDVLH 494 VI+HEI H WFG+LVT W + WL EGF Y + + T + + +L Sbjct: 322 -VIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLR 380 Query: 495 EVMLLDGLASSHPVSQ---EVLQATDIDRVFDWIAYKKGAALIRMLANFMG-HSVFQRGL 550 + M + G +P+++ ++ D D ++ Y+KG + LA+ +G F L Sbjct: 381 QHMDITG--EENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFL 438 Query: 551 QDYLTIHKYGNAARNDLWNTLSE---ALKRNGKYVNIQEVMDQWTLQMGYP 598 + Y+ K+ + +D + E LK+ + D+W G+P Sbjct: 439 KAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWP 489 >gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Homo sapiens] Length = 494 Score = 66.6 bits (161), Expect = 1e-10 Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 17/187 (9%) Query: 387 PYSLPKLDLLAVP-KHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQ 445 PY + D++ +P P AMEN L+ + + D + ++DV +HE+ H Sbjct: 77 PYMWGRYDIVFLPPSFPIVAMENPCLTFIISSILESDEFL-----VIDV----IHEVAHS 127 Query: 446 WFGDLVTPVWWEDVWLKEGFAHYFE-FVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLAS 504 WFG+ VT WE++WL EG A Y + + T+ + + F D LH M L L Sbjct: 128 WFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKL--LGE 185 Query: 505 SHPVSQ---EVLQATDIDRVFDWIAYKKGAALIRMLANFMGH-SVFQRGLQDYLTIHKYG 560 PVS+ ++ + + + Y+KG + L+ G F L+ Y+ +K+ Sbjct: 186 DSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFT 245 Query: 561 NAARNDL 567 + DL Sbjct: 246 SVVAQDL 252 >gi|188536004 zinc finger protein 469 [Homo sapiens] Length = 3925 Score = 35.4 bits (80), Expect = 0.28 Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 4/71 (5%) Query: 62 SLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTS 121 S + A+ P A G P RG + PGS +G DSW P A + PG Sbjct: 193 STNYTSPSATPRPPAPGPPQS---RGTSPLQPGSYPEYQASGADSWPPAAEN-SFPGANF 248 Query: 122 AQPPSEEEREP 132 PP+E E P Sbjct: 249 GVPPAEPEPIP 259 Score = 31.2 bits (69), Expect = 5.2 Identities = 24/74 (32%), Positives = 31/74 (41%), Gaps = 4/74 (5%) Query: 75 GADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVA-SPGTTSAQPPSEEEREPW 133 G DG P+ E GG+ PG R+ A G S E G A G A PS ++P Sbjct: 1119 GGDGAPANPEEPGGSRPGPG---RSPQARGPSRSLETGAAAREGGPKCADRPSVAPKDPL 1175 Query: 134 EPWTQLRLSGHLKP 147 + T S +P Sbjct: 1176 QVPTNTETSEETRP 1189 >gi|21389407 hexamthylene bis-acetamide inducible 2 [Homo sapiens] Length = 286 Score = 35.4 bits (80), Expect = 0.28 Identities = 28/87 (32%), Positives = 36/87 (41%), Gaps = 21/87 (24%) Query: 73 TPGADGGPSGFPER-GGNGSLPGSARRNHHA---------GGDSWQPEAGGVASPGTTSA 122 T GA G P PER GSLP + R H+ GG W + SPG SA Sbjct: 23 TSGAPGSPQTPPERHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSPRTQSPGGCSA 82 Query: 123 QP----------PSEEEREPWEPWTQL 139 + PS+ +R W P+ +L Sbjct: 83 EAVLARKKHRRRPSKRKRH-WRPYLEL 108 >gi|4507347 TBP-associated factor 2 [Homo sapiens] Length = 1199 Score = 35.4 bits (80), Expect = 0.28 Identities = 43/199 (21%), Positives = 80/199 (40%), Gaps = 18/199 (9%) Query: 276 FPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEED-GWVTDHFSQTPLMSTYYLAW 334 FPC D T+K+ A +++SN + +V+ D T H+ T + ++ Sbjct: 190 FPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISL 249 Query: 335 AICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYF--KVPYSLPK 392 AI F V + + + + Y LH + EFYE+ + PYS K Sbjct: 250 AIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSY-LH---EVFEFYEEILTCRYPYSCFK 305 Query: 393 ---LDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGD 449 +D V YA+M + ++ I+ + ++ + + Q+FG Sbjct: 306 TVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTR--------RCLAQSLAQQFFGC 357 Query: 450 LVTPVWWEDVWLKEGFAHY 468 ++ + W D W+ +G + Y Sbjct: 358 FISRMSWSDEWVLKGISGY 376 >gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens] Length = 1838 Score = 35.0 bits (79), Expect = 0.36 Identities = 23/63 (36%), Positives = 25/63 (39%), Gaps = 5/63 (7%) Query: 69 GASATPGADG-----GPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQ 123 G PG DG GP GFP G PG A ++ G E G SPG T Sbjct: 1324 GPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEP 1383 Query: 124 PPS 126 PS Sbjct: 1384 GPS 1386 >gi|116256354 alpha 2 type IV collagen preproprotein [Homo sapiens] Length = 1712 Score = 35.0 bits (79), Expect = 0.36 Identities = 23/65 (35%), Positives = 27/65 (41%), Gaps = 1/65 (1%) Query: 69 GASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEE 128 G S PGADG P G P +GG PG N G Q G G Q P + Sbjct: 109 GVSGFPGADGIP-GHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQ 167 Query: 129 EREPW 133 + EP+ Sbjct: 168 KGEPY 172 >gi|153267418 EDAR-associated death domain isoform A [Homo sapiens] Length = 215 Score = 34.3 bits (77), Expect = 0.62 Identities = 27/91 (29%), Positives = 39/91 (42%), Gaps = 8/91 (8%) Query: 893 TCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYG 952 +C ++ + LL S+++ DQD +DVI H W+ F KW Y Sbjct: 95 SCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKW---GMSYD 151 Query: 953 EALFMNSKLISGVTEFL-----NTEGELKEL 978 E F+ + S EFL T G+L EL Sbjct: 152 ELCFLEQRPQSPTLEFLLRNSQRTVGQLMEL 182 >gi|18152769 EDAR-associated death domain isoform B [Homo sapiens] Length = 205 Score = 34.3 bits (77), Expect = 0.62 Identities = 27/91 (29%), Positives = 39/91 (42%), Gaps = 8/91 (8%) Query: 893 TCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYG 952 +C ++ + LL S+++ DQD +DVI H W+ F KW Y Sbjct: 85 SCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKW---GMSYD 141 Query: 953 EALFMNSKLISGVTEFL-----NTEGELKEL 978 E F+ + S EFL T G+L EL Sbjct: 142 ELCFLEQRPQSPTLEFLLRNSQRTVGQLMEL 172 >gi|239756892 PREDICTED: hypothetical protein [Homo sapiens] Length = 576 Score = 33.9 bits (76), Expect = 0.81 Identities = 18/50 (36%), Positives = 24/50 (48%) Query: 75 GADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQP 124 G GG + +R G + PGS RR AG + P GG + P +A P Sbjct: 256 GPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPP 305 >gi|239751388 PREDICTED: hypothetical protein XP_002347834 [Homo sapiens] Length = 404 Score = 33.9 bits (76), Expect = 0.81 Identities = 18/50 (36%), Positives = 24/50 (48%) Query: 75 GADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQP 124 G GG + +R G + PGS RR AG + P GG + P +A P Sbjct: 256 GPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPP 305 >gi|239745895 PREDICTED: hypothetical protein XP_002343612 [Homo sapiens] Length = 404 Score = 33.9 bits (76), Expect = 0.81 Identities = 18/50 (36%), Positives = 24/50 (48%) Query: 75 GADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQP 124 G GG + +R G + PGS RR AG + P GG + P +A P Sbjct: 256 GPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPP 305 >gi|122937249 glutamate receptor interacting protein 2 [Homo sapiens] Length = 1141 Score = 33.9 bits (76), Expect = 0.81 Identities = 21/69 (30%), Positives = 27/69 (39%), Gaps = 1/69 (1%) Query: 70 ASATPGADGGPSGF-PERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEE 128 +SAT G GGP + P+ G+ P R G +P P EE Sbjct: 887 SSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEE 946 Query: 129 EREPWEPWT 137 E + WEP T Sbjct: 947 EEDDWEPPT 955 >gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens] Length = 1466 Score = 33.1 bits (74), Expect = 1.4 Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 1/58 (1%) Query: 69 GASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPS 126 G+ PG DG P G +RG NGS PG+ H G AG G + P+ Sbjct: 1017 GSDGLPGRDGSPGGKGDRGENGS-PGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPA 1073 Score = 32.7 bits (73), Expect = 1.8 Identities = 21/70 (30%), Positives = 28/70 (40%), Gaps = 2/70 (2%) Query: 67 ECGASATPGADGGPS--GFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQP 124 E G+ PGA G P G P G+ PG + G D AG +PG+ Sbjct: 862 ERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSG 921 Query: 125 PSEEEREPWE 134 P + +P E Sbjct: 922 PKGDAGQPGE 931 Score = 31.6 bits (70), Expect = 4.0 Identities = 23/58 (39%), Positives = 26/58 (44%), Gaps = 9/58 (15%) Query: 69 GASATPGADG-----GPSGFPERGGNGSLPGS--ARRNHHAGGDSWQPEAGGVASPGT 119 G + PG +G GP G P G LPG+ AR N A G QP G PGT Sbjct: 285 GENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQP--GPPGPPGT 340 Score = 31.2 bits (69), Expect = 5.2 Identities = 20/50 (40%), Positives = 23/50 (46%), Gaps = 1/50 (2%) Query: 69 GASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPG 118 GA+ PG DG P G RG GS PG + G Q E+G PG Sbjct: 519 GAAGEPGRDGVPGGPGMRGMPGS-PGGPGSDGKPGPPGSQGESGRPGPPG 567 Score = 30.4 bits (67), Expect = 8.9 Identities = 22/67 (32%), Positives = 29/67 (43%), Gaps = 8/67 (11%) Query: 69 GASATPGADG-----GPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASP--GTTS 121 G +PG G GP+GFP G PG + A G+ + GVA P G+ Sbjct: 792 GPRGSPGERGETGPPGPAGFPGAPGQNGEPG-GKGERGAPGEKGEGGPPGVAGPPGGSGP 850 Query: 122 AQPPSEE 128 A PP + Sbjct: 851 AGPPGPQ 857 >gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] Length = 1796 Score = 32.7 bits (73), Expect = 1.8 Identities = 23/68 (33%), Positives = 27/68 (39%), Gaps = 4/68 (5%) Query: 67 ECGASATPGADG--GPSGFPERGGNGSLPGSARRNHHAG--GDSWQPEAGGVASPGTTSA 122 E G +PGA G GP G P GN +PG+ G G+ P G G Sbjct: 1658 EPGRPGSPGAPGEQGPPGTPGFPGNAGVPGTPGERGLTGIKGEKGNPGVGTQGPRGPPGP 1717 Query: 123 QPPSEEER 130 PS E R Sbjct: 1718 AGPSGESR 1725 >gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] Length = 2217 Score = 32.3 bits (72), Expect = 2.3 Identities = 20/67 (29%), Positives = 27/67 (40%) Query: 64 RFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQ 123 R D G PG GP+G E + PG R + +S Q E G+ + Q Sbjct: 7 RRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQ 66 Query: 124 PPSEEER 130 PP +R Sbjct: 67 PPQPLQR 73 >gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens] Length = 1499 Score = 32.0 bits (71), Expect = 3.1 Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 10/76 (13%) Query: 67 ECGASATPGADGGPSGFPERGGNGS--------LPGSARRNHHAG--GDSWQPEAGGVAS 116 E G + TPG G G E+G G+ LPG AG G+ +P G+ Sbjct: 766 ERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVG 825 Query: 117 PGTTSAQPPSEEEREP 132 P + P S E P Sbjct: 826 PPGSRGNPGSRGENGP 841 >gi|239744898 PREDICTED: hypothetical protein XP_002343297 [Homo sapiens] Length = 210 Score = 32.0 bits (71), Expect = 3.1 Identities = 38/130 (29%), Positives = 48/130 (36%), Gaps = 30/130 (23%) Query: 11 GSRGLSDP--WAD--SVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTM---------- 56 GSRG P WA + G R E H+ R +A A L V+ Sbjct: 83 GSRGRRRPPSWARRRARGGRGSCPEPHVRAGPRFFIALAAPAARGLRVSSQGPGLWRGPA 142 Query: 57 ----------LAVLLSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDS 106 +A L LR G TP G P+ FP + G+ RNH A + Sbjct: 143 ARKEGVARVGVAAGLRLRPRGRGRKTTPALSGHPARFPLQPGDSR---ERSRNHRALELT 199 Query: 107 WQP---EAGG 113 WQP +AGG Sbjct: 200 WQPRGAKAGG 209 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.136 0.420 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 37,108,081 Number of Sequences: 37866 Number of extensions: 1651718 Number of successful extensions: 6035 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 21 Number of HSP's successfully gapped in prelim test: 46 Number of HSP's that attempted gapping in prelim test: 5584 Number of HSP's gapped (non-prelim): 390 length of query: 1024 length of database: 18,247,518 effective HSP length: 112 effective length of query: 912 effective length of database: 14,006,526 effective search space: 12773951712 effective search space used: 12773951712 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.