Search of human proteins with 68160947

Search of human proteins with 68160947

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|68160947 secretogranin II precursor [Homo sapiens]
         (617 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|68160947 secretogranin II precursor [Homo sapiens]                1239   0.0  
gi|148746195 trichohyalin [Homo sapiens]                               46   1e-04
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    44   4e-04
gi|221219020 NYD-SP11 protein [Homo sapiens]                           44   6e-04
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...    43   7e-04
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr...    43   7e-04
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    42   0.002
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    42   0.002
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              40   0.005
gi|96975038 coiled-coil domain containing 100 [Homo sapiens]           40   0.005
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    40   0.006
gi|239745058 PREDICTED: hypothetical protein XP_002343353 [Homo ...    40   0.006
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     40   0.006
gi|94721321 coiled-coil domain containing 11 [Homo sapiens]            40   0.006
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    39   0.011
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    39   0.014
gi|150170670 piccolo isoform 2 [Homo sapiens]                          39   0.014
gi|150378539 piccolo isoform 1 [Homo sapiens]                          39   0.014
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    39   0.018
gi|21735569 claspin [Homo sapiens]                                     39   0.018
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]               39   0.018
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    38   0.024
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    38   0.024
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ...    38   0.024
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s...    38   0.024
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa...    38   0.024
gi|52856430 protein expressed in prostate, ovary, testis, and pl...    38   0.031
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]           38   0.031
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    37   0.041
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    37   0.041

>gi|68160947 secretogranin II precursor [Homo sapiens]
          Length = 617

 Score = 1239 bits (3207), Expect = 0.0
 Identities = 617/617 (100%), Positives = 617/617 (100%)

Query: 1   MAEAKTHWLGAALSLIPLIFLISGAEAASFQRNQLLQKEPDLRLENVQKFPSPEMIRALE 60
           MAEAKTHWLGAALSLIPLIFLISGAEAASFQRNQLLQKEPDLRLENVQKFPSPEMIRALE
Sbjct: 1   MAEAKTHWLGAALSLIPLIFLISGAEAASFQRNQLLQKEPDLRLENVQKFPSPEMIRALE 60

Query: 61  YIENLRQQAHKEESSPDYNPYQGVSVPLQQKENGDESHLPERDSLSEEDWMRIILEALRQ 120
           YIENLRQQAHKEESSPDYNPYQGVSVPLQQKENGDESHLPERDSLSEEDWMRIILEALRQ
Sbjct: 61  YIENLRQQAHKEESSPDYNPYQGVSVPLQQKENGDESHLPERDSLSEEDWMRIILEALRQ 120

Query: 121 AENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFK 180
           AENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFK
Sbjct: 121 AENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFK 180

Query: 181 RTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIA 240
           RTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIA
Sbjct: 181 RTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIA 240

Query: 241 YEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESK 300
           YEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESK
Sbjct: 241 YEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESK 300

Query: 301 DQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQI 360
           DQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQI
Sbjct: 301 DQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQI 360

Query: 361 PPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLFQNRMLSKSGYPKTPG 420
           PPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLFQNRMLSKSGYPKTPG
Sbjct: 361 PPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLFQNRMLSKSGYPKTPG 420

Query: 421 RAGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLPYGAGRSRSNQLPK 480
           RAGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLPYGAGRSRSNQLPK
Sbjct: 421 RAGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLPYGAGRSRSNQLPK 480

Query: 481 AAWIPHVENRQMAYENLNDKDQELGEYLARMLVKYPEIINSNQVKRVPGQGSSEDDLQEE 540
           AAWIPHVENRQMAYENLNDKDQELGEYLARMLVKYPEIINSNQVKRVPGQGSSEDDLQEE
Sbjct: 481 AAWIPHVENRQMAYENLNDKDQELGEYLARMLVKYPEIINSNQVKRVPGQGSSEDDLQEE 540

Query: 541 EQIEQAIKEHLNQGSSQETDKLAPVSKRFPVGPPKNDDTPNRQYWDEDLLMKVLEYLNQE 600
           EQIEQAIKEHLNQGSSQETDKLAPVSKRFPVGPPKNDDTPNRQYWDEDLLMKVLEYLNQE
Sbjct: 541 EQIEQAIKEHLNQGSSQETDKLAPVSKRFPVGPPKNDDTPNRQYWDEDLLMKVLEYLNQE 600

Query: 601 KAEKGREHIAKRAMENM 617
           KAEKGREHIAKRAMENM
Sbjct: 601 KAEKGREHIAKRAMENM 617


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/278 (21%), Positives = 115/278 (41%), Gaps = 31/278 (11%)

Query: 31   QRNQLLQKEPDLRL--ENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPL 88
            +  QLL +EP+ R   E  +K+   E ++  E  E L ++  ++    ++          
Sbjct: 969  KEEQLLGEEPEKRRRQEREKKYREEEELQQEE--EQLLREEREKRRRQEWE--------- 1017

Query: 89   QQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMS 148
            +Q    DE    E   L EE   R + E  RQ   E +   +E +      E     ++ 
Sbjct: 1018 RQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077

Query: 149  DDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKL 208
              Y  ++  +++          E+  R+ P KR  +  E Q   +     E + QE  +L
Sbjct: 1078 RQYRKEEELQQE---------EEQLLREEPEKRRRQERERQCREE-----EELQQEEEQL 1123

Query: 209  TGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDS 268
                 +KR R + E++ Y ++E+   +   +  E+    E     E + + + +EE++  
Sbjct: 1124 LREEREKRRRQELERQ-YREEEEVQQEEEQLLREEP---EKRRRQELERQYREEEELQQE 1179

Query: 269  KENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDD 306
            +E + + EQ     +R  Q   +EE  R++ K +  D+
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 63/315 (20%), Positives = 129/315 (40%), Gaps = 40/315 (12%)

Query: 32  RNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPY-QGVSVPLQQ 90
           R++ L++EP  R    ++    E+    E  E   +   ++    D   + Q      ++
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184

Query: 91  KENGDESHLP-----ERDSLSEEDWMRI--ILEALRQAENEPQSAPKENKPYALNSEKNF 143
           +   +E  L      E +   +E+ +R   +LE  R+   E Q   +E +      E   
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE--- 241

Query: 144 PMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQ 203
                   E ++W +R+    +     EE  ++   +R  E+ EE+   + L  LE   Q
Sbjct: 242 --------EEKEWRKRETVLRK----EEEKLQEEEPQRQRELQEEE---EQLRKLER--Q 284

Query: 204 ELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQE 263
           EL +      Q+++R+  EQ+L    E++  +            E+    +E+ E Q  E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ----------EERREQQERREQQ--E 332

Query: 264 EVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGS 323
           E R+ +   E+ E+   +++R  +   +E+ LR+E +++  +   +    L+R       
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392

Query: 324 GRLQNGQNGERATRL 338
            +L+  Q   R  +L
Sbjct: 393 QQLRREQQLRREQQL 407



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 54/277 (19%), Positives = 120/277 (43%), Gaps = 30/277 (10%)

Query: 31   QRNQLLQKEPDLR-LENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQ 89
            +R Q  ++E +L+ LE  ++    E  + L+  E+  Q+  +   S +    Q     L+
Sbjct: 820  RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879

Query: 90   QKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSD 149
            ++       L  + +L E+  +R   + L++ E E Q   +E +                
Sbjct: 880  EERKRRRHTLYAKPALQEQ--LRKEQQLLQEEEEELQREEREKR-------------RRQ 924

Query: 150  DYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLT 209
            + E Q   E +L+  +     E+  R+   KR  +  E QY        + + Q+  +L 
Sbjct: 925  EQERQYREEEQLQQEE-----EQLLREEREKRRRQERERQYRKD-----KKLQQKEEQLL 974

Query: 210  GPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSK 269
            G   +KR R + E+K Y ++E+   +   +  E+    E     E + + + ++E++  +
Sbjct: 975  GEEPEKRRRQEREKK-YREEEELQQEEEQLLREE---REKRRRQEWERQYRKKDELQQEE 1030

Query: 270  ENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDD 306
            E + + E+    ++   +   +EE+L++E +  L ++
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 56/283 (19%), Positives = 113/283 (39%), Gaps = 36/283 (12%)

Query: 26   EAASFQRNQLLQKEPDLRLENV---QKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQ 82
            E    +  QLL++EP+ R       Q     E+ +  E +    Q+  ++E    Y   +
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203

Query: 83   GVSVPLQQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKN 142
             +    +++   DE      D  S+  W         Q E E ++A ++NK Y    E  
Sbjct: 1204 ELQRQKRKQRYRDE------DQRSDLKW---------QWEPEKENAVRDNKVYCKGRENE 1248

Query: 143  FPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVF 202
                + D     +  ++ L+H+    + E+  RD   +R      +++ P+         
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHL----LGEQQERDREQERRRWQQRDRHFPEE-------- 1296

Query: 203  QELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQ 262
            ++L +      ++R+R  +E+K    +E +  +       D    E+   ++E+ E   +
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREERE--EKRRRQETDRKFREEEQLLQEREEQPLR 1354

Query: 263  EEVRDSK---ENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQ 302
             + RD K   E +   EQ    ++   +L  QE + RK  K++
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE-RKFLKEE 1396



 Score = 36.6 bits (83), Expect = 0.070
 Identities = 60/287 (20%), Positives = 112/287 (39%), Gaps = 38/287 (13%)

Query: 31   QRNQLLQKEPDLRL-ENVQKFPSPEMIRA-LEYIENLRQQAHKEESSPDYNPYQGVSVPL 88
            +  QL ++E D +  E  Q+    E  R  LE  + LRQ+ H++    +    +     L
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478

Query: 89   QQKENGDESHLPERDSLSEEDWMRIILEA-LRQAENEPQSAPKENKPYALNSEKNFPMDM 147
             ++E  D   L E   L  ++  R   E  LR  E E +   +E + +    ++ F  + 
Sbjct: 1479 HRQER-DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537

Query: 148  SDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGK 207
                  ++  +R+              RD  F+   ++ +E+   Q         QE  +
Sbjct: 1538 QQLRRQERGQQRR------------QDRDRKFREEEQLRQEREEQQLSR------QERDR 1579

Query: 208  LTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAY----EDVVGGEDWNPVEEKIESQTQE 263
                  QK  R ++E+K + +DE  + +           D    ED   ++E+ E Q   
Sbjct: 1580 KFRLEEQKVRRQEQERK-FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638

Query: 264  EVRDSK--------ENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQ 302
            + RD K           E+ +Q+  +  R  +   +EE L +E ++Q
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHDRDRKFR---EEEQLLQEGEEQ 1682



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 61/291 (20%), Positives = 116/291 (39%), Gaps = 25/291 (8%)

Query: 30   FQRNQLLQKEPDLR-LENVQKFPSPEMIRA-LEYIENLRQQAHKEESSPDYNPYQGVSVP 87
            F+  +L  +EP+ + LE  Q+    +  R  L+  + LR+Q   ++   D +        
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562

Query: 88   LQQKENGDESHLPERDSLS--EEDWMRIILEALRQAENEPQSAPKENKPYALNS-EKNFP 144
            L+Q+    +    ERD     EE  +R   +  +  E+E Q   +E +       ++ F 
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622

Query: 145  MD--MSDDYETQQW--PERKLKHMQFPPMYEENSRDNPFK--RTNEIVEEQYTPQSLATL 198
             D  +  + E QQ    ER  K ++  P      R+   +  R  +  EE+   Q     
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682

Query: 199  ESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIE 258
            +   QE  +      Q+  R + E+K   +++    +     + +          EE++ 
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE----------EEQLR 1732

Query: 259  SQTQEEVRDSKENIEK---NEQINDEMKRSGQLGIQEEDLRKESKDQLSDD 306
             +T++E    +E   K    EQ+  E +   QL  QE D +   ++QL  +
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPE-REEQQLRRQERDRKFREEEQLRQE 1782



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 57/282 (20%), Positives = 113/282 (40%), Gaps = 24/282 (8%)

Query: 31   QRNQLLQKEPD--LRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPL 88
            +  QL ++E D   RLE  +     +  + +E  + LR+Q  +++   + +        L
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627

Query: 89   QQKENGDESHLPERDS--LSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMD 146
             Q+    + H  ERD   L EE         LR+ E E Q     ++ +    E+    +
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEP-------QLRRQEREQQLRHDRDRKF--REEEQLLQE 1678

Query: 147  MSDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELG 206
              +    +Q  +RK +  +         R+  F +  + +  Q   +     E + QE  
Sbjct: 1679 GEEQQLRRQERDRKFREEE--QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE 1736

Query: 207  KLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVR 266
            +      ++  ++ EE++L  + E+   +       D    E+    +E+ E Q + +  
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQQLRRQE---RDRKFREEEQLRQEREEQQLRSQES 1793

Query: 267  DSK----ENI--EKNEQINDEMKRSGQLGIQEEDLRKESKDQ 302
            D K    E +  E+ EQ     +R G+   +EE L+ E ++Q
Sbjct: 1794 DRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 65/300 (21%), Positives = 114/300 (38%), Gaps = 32/300 (10%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKE------------ESSPDY 78
           +  +L ++E + RLE   K    E  R  E  E  ++QA +             ES  D 
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714

Query: 79  NPYQGVSVPLQQK--ENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAP------K 130
              +  S P +Q+      E     R   SE  W      A RQ + E Q          
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE-RAHRQQQEEEQRRDFTWQWQA 773

Query: 131 ENKPYALNSEKNFPMDMSDDYETQ-QWPERKLKHMQFPPMYEENSRDNPFKRTNE----I 185
           E K        +    + +  E Q +  ER+ +  +F P  EE  +    +R  E     
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833

Query: 186 VEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEE---QKLYTDDEDDIYKANNIAYE 242
           +EE+   Q     + + +E   L    +Q+R R  E+   QK     E++  +  +  Y 
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQ--EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891

Query: 243 DVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQ 302
                E     ++ ++ + +E  R+ +E   + EQ   + +   QL  +EE L +E +++
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ-ERQYREEEQLQQEEEQLLREEREK 950



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 56/280 (20%), Positives = 110/280 (39%), Gaps = 10/280 (3%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQ 90
           +R Q L++E  LR E  Q+    + +R  +  E   Q+  +E         Q       +
Sbjct: 402 RREQQLRREQQLRRE--QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459

Query: 91  KENGDESHLPERDSLS-EEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMS- 148
           +E   E H  ER     + D      E   + E E +   +E +   L  E+    +   
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519

Query: 149 DDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKL 208
              E ++  +++L+  Q     +E  R+   KR  E   EQ   +     E   +    L
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579

Query: 209 TGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGG--EDWNPVEEK----IESQTQ 262
                ++++R+  EQ+   +      +   +  E+      +   P EE+    ++S+ Q
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639

Query: 263 EEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQ 302
           EE R  +   E+ E+    +KR  +    E+ L++E +++
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 22/110 (20%), Positives = 52/110 (47%), Gaps = 3/110 (2%)

Query: 199 ESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIE 258
           ++ +  LG+ TG + +KR R D ++ L  D   +  +      +  +  E      +K +
Sbjct: 83  QACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ 142

Query: 259 SQTQEEVRDSKENIEKNEQI--NDEMKRSGQLGIQEEDLRKESKDQLSDD 306
            Q + E+ + +E  EK E++   D  +R  +L  Q ++ ++  + +  ++
Sbjct: 143 EQ-ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 55/297 (18%), Positives = 124/297 (41%), Gaps = 22/297 (7%)

Query: 31  QRNQLLQKEPDLR-----LENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVS 85
           Q  +L +KE  +R      E  +K    E IR  E  + +R++        +    Q  +
Sbjct: 364 QDERLREKEERMREQEKMWEQEEKMQEEERIRERE--KKMREEEETMREQEEKMQKQEEN 421

Query: 86  VPLQQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPM 145
           +  Q+++   +  LPE+    E+ W +  ++   +   E +   ++ +      +K +  
Sbjct: 422 MWEQEEKEWQQQRLPEQ---KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 478

Query: 146 DMSDDYETQQWPERKLKHMQFPPMYEENSR----DNPFKRTNEIVEEQ---YTPQSLATL 198
           +   + E Q W + +    Q   M+++  R    D   +   E + EQ   +  +     
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538

Query: 199 ESVFQELGKLTGPNNQK---RERMDEEQKLYTDDEDDIYKANNIAYE--DVVGGEDWNPV 253
           E   QE  K T    +K    ERM E +K   ++E+ + +      E  + +  ++    
Sbjct: 539 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598

Query: 254 EEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKV 310
           E++ + Q QEE    +E     ++  D+M+   ++  ++E+  +E ++++ +   K+
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM 655



 Score = 30.8 bits (68), Expect = 3.8
 Identities = 34/200 (17%), Positives = 84/200 (42%), Gaps = 25/200 (12%)

Query: 89  QQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMS 148
           ++K   +E  + E++   +E   ++  +  +  E E +   +E K +    EK +  +  
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE-QEEKMWEQEEE 624

Query: 149 DDYETQQ---WPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQEL 205
           D  + Q+   W + +    Q   M+E+  +    +      EE+   Q     E + ++ 
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE----EKMREQE 680

Query: 206 GKLTGPNNQKRERMD----EEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQT 261
            K+ G   + RE+ +    +E+K++               E+ + G++     ++   + 
Sbjct: 681 EKMQGQEEKMREQEEKMRGQEEKMW-------------GQEEKMWGQEEKMWGQEEMREK 727

Query: 262 QEEVRDSKENIEKNEQINDE 281
           +E +RD KE +++    ++E
Sbjct: 728 EERIRDQKEKMQERLPEHEE 747


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 44/215 (20%), Positives = 99/215 (46%), Gaps = 28/215 (13%)

Query: 95   DESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSD--DYE 152
            DE  L  +         R+I +  +  E E + A K ++   L+ E+   ++  +   + 
Sbjct: 2135 DEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSE-VILDDEEEGGIEEEEVIPFL 2193

Query: 153  TQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLAT-LESVFQELGKLTGP 211
             ++W +RK          E    D P ++ +  V+E  + +  +  +ES+  EL K    
Sbjct: 2194 KRRWRKRK----------EAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESL 2243

Query: 212  NNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKEN 271
            ++++ E  +EE++    +E+++ +      E+  G E    VE++ E + +++    KE 
Sbjct: 2244 SSEEEEEREEEEER---EEEEVREEEEERKEEEEGEE--KQVEKEEEEKKKKKKEKKKEE 2298

Query: 272  IEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDD 306
            +++ E++ +E         +EE + +E  + LSD+
Sbjct: 2299 VQEKEEVFEE---------KEEIMSEEETESLSDE 2324



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 19/101 (18%), Positives = 52/101 (51%), Gaps = 5/101 (4%)

Query: 214  QKRERMDEEQKLYTDDEDDIYKANNIAYE-----DVVGGEDWNPVEEKIESQTQEEVRDS 268
            ++ +R D+ ++ ++   D++    + + E     D +  ++    EE+ E + +EE  + 
Sbjct: 2201 KEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEE 2260

Query: 269  KENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSK 309
            +   E+ E+  +E     Q+  +EE+ +K+ K++  ++V +
Sbjct: 2261 EVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301



 Score = 30.8 bits (68), Expect = 3.8
 Identities = 41/220 (18%), Positives = 96/220 (43%), Gaps = 20/220 (9%)

Query: 158  ERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRE 217
            ++KLK  ++  ++E          +++  E+QY  +   TLE      G+      +K +
Sbjct: 1513 DKKLKWEEWKQVWEN-------MLSSKSKEQQYKDEEEVTLEEEVSREGE------EKEQ 1559

Query: 218  RMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIE---- 273
            ++ EEQ+   ++          A  +    ++   + ++ E   QEE + ++E  +    
Sbjct: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619

Query: 274  --KNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQN 331
              K  Q + EM ++     Q+E+   +  ++LS +  K+    K+L         +  + 
Sbjct: 1620 YVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKL 1679

Query: 332  GERATRLFE-KPLDSQSIYQLIEISRNLQIPPEDLIEMLK 370
             ++  +L E K + +Q + +L +  +NL    ++L + L+
Sbjct: 1680 AKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 42/188 (22%), Positives = 89/188 (47%), Gaps = 14/188 (7%)

Query: 178  PFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDI-YKA 236
            P +  N   +E+   Q L  LE   +EL       NQ+  ++ EE+K   ++E+ + ++ 
Sbjct: 1701 PQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQR 1760

Query: 237  NNIAYEDV-VGGEDWNPVEEKIE-SQTQEEVRDSKENI-EKNEQ-INDEMKRSGQLGIQE 292
              ++ E+  +  E+   ++EK + +Q +E++ + +E +  K EQ I  +MK +     Q+
Sbjct: 1761 EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLA-----QK 1815

Query: 293  EDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQN--GERATRLFEKPLDSQSIYQ 350
             +    S ++L+   +K+I Y K+ +        Q  +     +   L+ K   + S  Q
Sbjct: 1816 RERWINSMEELTK--NKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQ 1873

Query: 351  LIEISRNL 358
            L+++   L
Sbjct: 1874 LVQVKNKL 1881


>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 66/353 (18%)

Query: 31   QRNQLLQKE-----PDLRLENVQKFPSPEMIRALEY------------------IENLRQ 67
            Q N  L+KE      DLR + V    S EM RAL                    ++N+++
Sbjct: 1015 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1074

Query: 68   QAHKEESSPD------YNPYQGVSVPLQQKENGDESHLPERDSLSEEDWMRIILEALRQA 121
            +  +E +          N  Q   VPL+Q E   +S     ++L EE      L+++++ 
Sbjct: 1075 KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE------LKSMQRC 1128

Query: 122  -ENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFK 180
             E E Q+  K ++   L ++KN  + +++  + ++  E+++  ++     +E    N  +
Sbjct: 1129 YEKEQQTVTKLHQ--LLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1186

Query: 181  RTNEIVEE-QYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKAN-N 238
              +++  E Q T Q+L  LE+      ++   +  K  + D E ++ + +E     AN N
Sbjct: 1187 EVSKLQSEVQNTKQALKKLET-----REVVDLSKYKATKSDLETQISSLNEK---LANLN 1238

Query: 239  IAYEDV-----------VGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQ 287
              YE+V           +  +D    +E +    ++E++D KE  +K+     E++R   
Sbjct: 1239 RKYEEVCEEVLHAKKKEISAKD---EKELLHFSIEQEIKDQKERCDKSLTTITELQRR-- 1293

Query: 288  LGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFE 340
              IQE   + E+KD    ++   +  LK+ +N        +G   +R ++L +
Sbjct: 1294 --IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLID 1344



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 21/85 (24%), Positives = 46/85 (54%), Gaps = 9/85 (10%)

Query: 222  EQKLYTDDEDDIYKANNIAYEDVVGGED----WNPVEEKIESQTQEEVRD---SKENIEK 274
            E K    + D I +   + Y  +V  E+    +   E++++ Q  E+ +    S+E ++K
Sbjct: 953  EIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1012

Query: 275  NEQINDEMKRSGQLGIQEEDLRKES 299
            N+Q ND++K+  ++   ++DLR ++
Sbjct: 1013 NKQENDKLKK--EIFTLQKDLRDKT 1035


>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 1 [Homo sapiens]
          Length = 1416

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 66/353 (18%)

Query: 31   QRNQLLQKE-----PDLRLENVQKFPSPEMIRALEY------------------IENLRQ 67
            Q N  L+KE      DLR + V    S EM RAL                    ++N+++
Sbjct: 1028 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1087

Query: 68   QAHKEESSPD------YNPYQGVSVPLQQKENGDESHLPERDSLSEEDWMRIILEALRQA 121
            +  +E +          N  Q   VPL+Q E   +S     ++L EE      L+++++ 
Sbjct: 1088 KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE------LKSMQRC 1141

Query: 122  -ENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFK 180
             E E Q+  K ++   L ++KN  + +++  + ++  E+++  ++     +E    N  +
Sbjct: 1142 YEKEQQTVTKLHQ--LLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199

Query: 181  RTNEIVEE-QYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKAN-N 238
              +++  E Q T Q+L  LE+      ++   +  K  + D E ++ + +E     AN N
Sbjct: 1200 EVSKLQSEVQNTKQALKKLET-----REVVDLSKYKATKSDLETQISSLNEK---LANLN 1251

Query: 239  IAYEDV-----------VGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQ 287
              YE+V           +  +D    +E +    ++E++D KE  +K+     E++R   
Sbjct: 1252 RKYEEVCEEVLHAKKKEISAKD---EKELLHFSIEQEIKDQKERCDKSLTTITELQRR-- 1306

Query: 288  LGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFE 340
              IQE   + E+KD    ++   +  LK+ +N        +G   +R ++L +
Sbjct: 1307 --IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLID 1357



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 21/85 (24%), Positives = 46/85 (54%), Gaps = 9/85 (10%)

Query: 222  EQKLYTDDEDDIYKANNIAYEDVVGGED----WNPVEEKIESQTQEEVRD---SKENIEK 274
            E K    + D I +   + Y  +V  E+    +   E++++ Q  E+ +    S+E ++K
Sbjct: 966  EIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1025

Query: 275  NEQINDEMKRSGQLGIQEEDLRKES 299
            N+Q ND++K+  ++   ++DLR ++
Sbjct: 1026 NKQENDKLKK--EIFTLQKDLRDKT 1048


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 53/281 (18%), Positives = 109/281 (38%), Gaps = 42/281 (14%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQ 90
           Q   + +KE  +R +    +   E +R        RQ+    E        + +    ++
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMR--------RQEEMMWEKEEKMRRQEEMMWEKEE 391

Query: 91  KENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDD 150
           K    E  + E++ + E++  R   E +R+ E   +   +E K +    +     +   +
Sbjct: 392 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE---QEAKMWRQEEKIREQEEKIRE 448

Query: 151 YETQQWPERKLKHMQFPPMYEENSRDNP-FKRTNEIVEEQYTPQSLATLESVFQELGKLT 209
            E + W + +  H Q     EE  ++     R  E + EQ         E ++++     
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ---------EEIWRQ----- 494

Query: 210 GPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSK 269
                 +E+M E+++     E+ +++      E           EEKI  Q ++  R  +
Sbjct: 495 ------KEKMHEQEEKIRKQEEKVWRQEEKIREQ----------EEKIREQEEKMWRQEE 538

Query: 270 ENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKV 310
           +  E+ E   +E K   Q  I EE+ R+E +D++     K+
Sbjct: 539 KIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKI 579


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 53/284 (18%), Positives = 122/284 (42%), Gaps = 49/284 (17%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQ 90
           Q  Q+ ++E  +R +  + +   E +R  E  E +R+Q    E        + +    ++
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLREKE--ERMREQEKMWEQVEKMREEKKMQEQ-EK 437

Query: 91  KENGDESHLPERDSLSE-EDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSD 149
           K    E  + E + + E E  MR   E +R+ E + Q             E+N       
Sbjct: 438 KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK-----------QEENMWEQEEK 486

Query: 150 DYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLT 209
           +++ Q+ PE+K K  +   M E+  +         I E++   + +   E ++ +  K+ 
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEK---------IWEQE---EKIRDQEEMWGQEKKMW 534

Query: 210 GPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVR--- 266
                ++E+M E++    + E+ +       ++           EE++E +TQE+ +   
Sbjct: 535 -----RQEKMREQEDQMWEQEEKMRDQEQKMWDQ----------EERMEKKTQEQEKKTW 579

Query: 267 DSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKV 310
           D +E + + E++ +  K+      +EE++ +E ++++ +   K+
Sbjct: 580 DQEEKMREEERMREREKKMR----EEEEMMREQEEKMQEQEEKM 619



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 54/276 (19%), Positives = 113/276 (40%), Gaps = 25/276 (9%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQ 90
           +R + +++E +   E  +K    E        EN+ +Q  KE       P Q   +  Q+
Sbjct: 454 EREKKMREEEETMREQEEKMQKQE--------ENMWEQEEKEWQQQRL-PEQKEKLWEQE 504

Query: 91  KENGDESHLPERDSL---SEEDW--MRIILEALRQAENEPQSAPKENKPYALNSEKNFPM 145
           K    E  + E++      EE W   + +    +  E E Q   +E K   +  ++    
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK---MRDQEQKMW 561

Query: 146 DMSDDYETQQWPERKLKHMQFPPMYEEN---SRDNPFKRTNEIVEEQYTPQSLATLESVF 202
           D  +  E +   + K    Q   M EE     R+   +   E++ EQ   + +   E   
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ--EEKMQEQEEKM 619

Query: 203 QELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQ 262
           QE  +      ++ E+M E+++   + E+ +++     +E     E    + E  + Q Q
Sbjct: 620 QEQEEKMW---EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676

Query: 263 EEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKE 298
           E++++ +E I + E++  + +   +    +E +R+E
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE 712



 Score = 36.6 bits (83), Expect = 0.070
 Identities = 54/255 (21%), Positives = 105/255 (41%), Gaps = 20/255 (7%)

Query: 60  EYIENLRQQAHK----EESSPDYNPYQGVSVPLQQKENGDESHLPERDSL--SEEDWMRI 113
           E  E +R Q  K    EE        Q      Q+++  +E  + ER+     EE+ MR 
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607

Query: 114 ILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWP-ERKLKHMQFPPMYEE 172
             E +++ E + Q   +E K +    +     +   + E + W  E K+   Q  P  +E
Sbjct: 608 QEEKMQEQEEKMQE--QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKE 665

Query: 173 NSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDD 232
              ++   +  E ++EQ         E    E  K+     Q++E+   +Q+   ++E  
Sbjct: 666 KLWEHEKMQEQEKMQEQ---------EEKIWEQEKME-KKTQEQEKKTWDQEKMREEESM 715

Query: 233 IYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQE 292
             +   +  E+ +  E    ++E+ E + QE+  +  E  EK  +  ++M    +L  Q+
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQ-EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK 774

Query: 293 EDLRKESKDQLSDDV 307
           E L +  K Q  + +
Sbjct: 775 EKLWEHEKMQEQEKI 789



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 49/283 (17%), Positives = 108/283 (38%), Gaps = 54/283 (19%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQ 90
           Q  ++ ++E  +R +        +M R  +  E   Q   +EE   D            +
Sbjct: 509 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERME 568

Query: 91  KENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDD 150
           K+  ++    E+ +  +E+ MR   E  R  E E +   +E        +     +   +
Sbjct: 569 KKTQEQ----EKKTWDQEEKMR---EEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621

Query: 151 YETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTG 210
            E + W + +    Q   M+E+  +   +++  ++ E+Q  P+    L            
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEK--MWEQEEKMWEQQRLPEQKEKL------------ 667

Query: 211 PNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVR---- 266
               + E+M E++K+   +E                 + W   +EK+E +TQE+ +    
Sbjct: 668 ---WEHEKMQEQEKMQEQEE-----------------KIWE--QEKMEKKTQEQEKKTWD 705

Query: 267 -------DSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQ 302
                  +S    EK  +  +EM R  +  +QE++ + + +++
Sbjct: 706 QEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 52/243 (21%), Positives = 105/243 (43%), Gaps = 40/243 (16%)

Query: 101 ERDSLSEEDWMRIIL-EALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPER 159
           ERD+LS E +   I  E L++   E Q    E  P A + +    +++ +        +R
Sbjct: 205 ERDALSLELYRNTITNEELKKKNAELQ----EKLPLAESEKSEIQLNVKE-------LKR 253

Query: 160 KLKHMQFP-PMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRER 218
           KL+  +F  P  + N+      R  E + EQ             +++ K      ++ ER
Sbjct: 254 KLERAKFLLPQVQTNTLQEEMWRQEEELREQE------------KKIRKQEEKMWRQEER 301

Query: 219 MDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQI 278
           + E++    + E+ +++      E           +EK   + ++E+R+ KE  E+ EQ+
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLRE-----------QEKELREQEKELREQKELREQEEQM 350

Query: 279 NDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRL 338
            ++ ++  +   QEE +R E ++++     ++    K++       R Q  +  E+  RL
Sbjct: 351 QEQEEKMWE---QEEKMR-EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406

Query: 339 FEK 341
            EK
Sbjct: 407 REK 409


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 79/405 (19%), Positives = 159/405 (39%), Gaps = 35/405 (8%)

Query: 187  EEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVG 246
            E Q   +S+  LE+  ++  +  G   Q+ E   +E +  T  E ++ ++     E    
Sbjct: 1914 EAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPE 1973

Query: 247  GEDWNPVEEKIESQTQE-EVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSD 305
             ED   +E ++E+Q  E E +   E++E  E    EM+ + +    E D  +       +
Sbjct: 1974 SEDVEALEVEVETQEAEGEAQPESEDVEAPE-AEGEMQEAEEEAQPESDGVEAQPKSEGE 2032

Query: 306  DVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQIPPEDL 365
            +  +V    ++       G  Q   +G  A    E+  +++   Q  E         ED+
Sbjct: 2033 EAQEVEGETQKT-----EGDAQPESDGVEAPEAEEEAQEAEGEVQ--EAEGEAHPESEDV 2085

Query: 366  IEMLKTGEKPNGSVEPERE-LDLPVDLDDISEAD-LDHPDLFQNRMLSKSGY--PKTPGR 421
                   ++  G  +PE E ++ P    +  +A+ ++ P+          G   P+  G 
Sbjct: 2086 -----DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140

Query: 422  AGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLP-YGAGRSRSNQLPK 480
            A  E+  +G+  +D       E  A  ++        +E+  P L    A  +     P+
Sbjct: 2141 AQPES--EGVEAQD------AEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE 2192

Query: 481  AAWIPHVENRQMAYENLNDKDQELGEYLARMLVKYPEIINSNQVKRVPGQGSSEDDLQEE 540
            +  I   E    A   L   +    E  A+     PE + + + +   G+   E + + +
Sbjct: 2193 SEGIEAPEAEGEAQPELEGVEAPEAEEEAQ---PEPEGVETPEAE---GEAQPESEGETQ 2246

Query: 541  EQIEQAIKEHLNQGSSQE-TDKLAPVSKRFPVGPPK-NDDTPNRQ 583
             + + + +  L  G S+E ++  +PV +  P  PP    DTP+++
Sbjct: 2247 GEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQR 2291


>gi|96975038 coiled-coil domain containing 100 [Homo sapiens]
          Length = 986

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 56/291 (19%), Positives = 120/291 (41%), Gaps = 30/291 (10%)

Query: 123 NEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQ-FPPMYEENSRDNPFKR 181
           +E Q+ P+E   Y    E     +M +D    Q  +++L HMQ     +++  R+     
Sbjct: 639 SEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLV 698

Query: 182 TNEIVE----EQYTPQSLATLESVFQELGKLTGP-NNQKRERMDEEQKLYTDDEDDIYKA 236
             ++ E    E    ++L  LE   Q+L  +      +K+E   E Q+   + +D I +A
Sbjct: 699 KKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRA 758

Query: 237 NNIAYEDVVGGEDWNPVE----EKIESQTQEEVRDSKEN---IEKN-EQINDEMKRSGQL 288
                ED +   +   ++    E+ + + Q+++ D++     +EK  +Q  D+     ++
Sbjct: 759 K----EDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEI 814

Query: 289 GIQEE-DLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQS 347
            +Q E +L    K +           L+R + +A   +L   Q   RA +   +    + 
Sbjct: 815 RLQSEINLLTLEKVE-----------LERKLESATKSKLHYKQQWGRALKELARLKQREQ 863

Query: 348 IYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEAD 398
             Q+  + +  +   +  +  L   EK     E +  LD+  +L+ + + +
Sbjct: 864 ESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQE 914


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/242 (21%), Positives = 107/242 (44%), Gaps = 23/242 (9%)

Query: 88   LQQKENGDESHLPE-RDSLSEEDWMRIILEA-LRQAENEPQSAPKEN--KPYALNSEKNF 143
            L ++  G+E  + E +D L  E +   + +  +++ + E +   +EN  K   L +EK  
Sbjct: 828  LTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKET 887

Query: 144  PMDMSDDYETQQWPERKLKHMQFPPMYE--ENSRDNPFKRTNEIVEEQYTPQSLATLESV 201
                 D  ET+   E+  + +     +E  + S+    +   EI ++ +T   L    S+
Sbjct: 888  LATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSM 947

Query: 202  F-QELGKLTGPNNQKRERM---DEEQKLYTDDEDDIYKA---NNIAYEDVVGGEDWNPVE 254
              +++  L   N +  E+M   +EE KL  ++E    KA    NI  E  +  +  N + 
Sbjct: 948  LTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLA 1007

Query: 255  E----------KIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLS 304
            E          + ++ TQ+  +  KEN +   ++N E ++  Q+ ++ +    + + QL 
Sbjct: 1008 EIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV 1067

Query: 305  DD 306
            ++
Sbjct: 1068 EE 1069



 Score = 31.2 bits (69), Expect = 2.9
 Identities = 58/236 (24%), Positives = 97/236 (41%), Gaps = 31/236 (13%)

Query: 91  KENGDESHLPERDSLSEEDWMRI---ILEALRQAENEPQSAPKENKPYALNSEKNFPMDM 147
           +E     +L    S  E++ M +   I E  R+AE E +   + N    +++ K+   D+
Sbjct: 469 EEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEK--RRNVENEVSTLKDQLEDL 526

Query: 148 SDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTP--QSLATLESVFQEL 205
               +  Q    KL  +Q   + E N        T   + + +T   +S++ LES+ +EL
Sbjct: 527 KKVSQNSQLANEKLSQLQ-KQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNREL 585

Query: 206 GKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAY-EDVVGGEDWNPV---EEKIESQT 261
                   Q+R R+ E  K  TD   D Y+   I   E    G D   +   + +I S  
Sbjct: 586 --------QERNRILENSKSQTDK--DYYQLQAILEAERRDRGHDSEMIGDLQARITS-L 634

Query: 262 QEEVRDSKENIEK--------NEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSK 309
           QEEV+  K N+EK         + +N   K    L I      K  + +L  +V++
Sbjct: 635 QEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNE 690


>gi|239745058 PREDICTED: hypothetical protein XP_002343353 [Homo
           sapiens]
          Length = 544

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/236 (22%), Positives = 96/236 (40%), Gaps = 30/236 (12%)

Query: 60  EYIENLRQQAHKEESSPDYNPYQGVSVPLQQKENG---DESHLPERDSLSEE---DWMRI 113
           E + + +++   + SS + NP Q + +  +++       E+  PE+ S   E   D  R 
Sbjct: 318 ELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDRE 377

Query: 114 ILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMY-EE 172
           + E +++  + P   P+       N          DD    Q   RK ++ QFP    EE
Sbjct: 378 VEEEIKKHGSNPVGLPE-------NLTNGASAGNGDDGLIPQRKSRKPENQQFPDTENEE 430

Query: 173 NSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQ---KRERMDEEQKLYTDD 229
              D       ++ EEQ T  S   +         LT    Q     + M+ E  L    
Sbjct: 431 YHSDEQNDTQKQLSEEQNTGISQDEI---------LTNKQKQIEVAEKEMNSELSLSHKK 481

Query: 230 EDDIYKANNIAYEDV----VGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDE 281
           E+D+ + N++  E++    +  ++     +  E++  EE+   KE + K  Q+N+E
Sbjct: 482 EEDLLRENSMLREEIAKLRLELDETKHQNQLRENKILEEIESVKEKLLKTIQLNEE 537


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 86/400 (21%), Positives = 167/400 (41%), Gaps = 47/400 (11%)

Query: 62  IENLRQQAHKEESSPDYNPYQGVSVPLQQKENGDESHLPE-RDSLSEEDWMRIILEA--- 117
           I+ L+Q+  K+ES  +    Q     L  + +  + H+   ++SL+ ++    IL+    
Sbjct: 436 IDQLKQELSKKES--ELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVD 493

Query: 118 ---LRQAENEPQSAPKENKPYALNSEKNFPM----DMSDDYETQQWP----ERKLKHMQF 166
              LR  E E     K  +   L  EK        DM D  E ++      ++K++++Q 
Sbjct: 494 ALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQE 553

Query: 167 PPMYEENSRDNPFKRTNEI-VEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKL 225
               ++    N   R   +  +   T  +LATLE    E  ++     ++RER D E+  
Sbjct: 554 QLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER-- 611

Query: 226 YTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRS 285
             ++ +   K N    E V      N ++ ++ ++ +  + D KE+   +   +  +KR 
Sbjct: 612 -LEEIESFRKENKDLKEKV------NALQAEL-TEKESSLIDLKEH--ASSLASAGLKRD 661

Query: 286 GQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDS 345
            +L   E  +     +Q  ++ SK+ A LK+  N     R+    N E A ++  K LD 
Sbjct: 662 SKLKSLEIAI-----EQKKEECSKLEAQLKKAHNIEDDSRM----NPEFADQI--KQLDK 710

Query: 346 QSIYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLF 405
           ++ Y   E  +  Q   + L+E+LK  E      + +      + L  + + +    +L 
Sbjct: 711 EASYYRDECGK-AQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLK 769

Query: 406 QNRMLSKSGYPK--TPGRAGTEALPDG---LSVEDILNLL 440
            N+ L K    +     R   +++ D    L +E+++N L
Sbjct: 770 HNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNAL 809


>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
          Length = 514

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 11/170 (6%)

Query: 184 EIVEEQYTPQ---SLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIA 240
           E ++++Y  +   ++  ++   Q+L +      QKRE M  EQK+Y       Y A    
Sbjct: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHK-----YLAQRRE 351

Query: 241 YEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESK 300
            E     E    +EE    +  E+ ++ +   E   Q+ DE+  + +L +QE+ L++E+K
Sbjct: 352 EEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEK-LQREAK 410

Query: 301 DQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQ 350
           +Q  ++ +    ++   +        +N    +R  + + K L  Q  YQ
Sbjct: 411 EQ--EERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQ 458


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 53/306 (17%), Positives = 122/306 (39%), Gaps = 21/306 (6%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALE-YIENLRQQAHKEESSPDYNPYQGVSVPLQ 89
           Q  Q+ ++E  +R +  Q       +R  E  +     Q  ++E        Q      Q
Sbjct: 148 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQ 207

Query: 90  QKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSD 149
             E  ++    E     +E+ MR   E + + E + Q   ++ +       K        
Sbjct: 208 MGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQ 267

Query: 150 DYETQQWPERKLKHMQFPPMYEENS-RDNPFKRTNEIVEEQYTPQSLATLESVFQELGKL 208
           + + ++  E+ LK  +     E+   ++   +   E + EQ   + +   E   +E  + 
Sbjct: 268 EEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQ--EEQMREQEEQMREQEEQ 325

Query: 209 TGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDS 268
            G   ++ E+M E+++   + ++ ++K            E     EE+++ Q +E+VR  
Sbjct: 326 MG---KQEEQMWEQKEQMWEQKEQMWKQE----------EQMGEQEEQMQKQ-EEQVRKQ 371

Query: 269 KENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQN 328
           +E + K E+   +M++  +   ++E+   E K+Q+ +   ++    +++       R Q 
Sbjct: 372 EEQMRKQEE---QMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQE 428

Query: 329 GQNGER 334
              GE+
Sbjct: 429 EHMGEQ 434



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 51/274 (18%), Positives = 109/274 (39%), Gaps = 19/274 (6%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQ 90
           Q  Q+ ++E  +R +  Q       +R  E  +   Q+    E        +G     + 
Sbjct: 85  QEGQVREQEGQVREQEGQVREQEGQVREQEG-QVREQEGQVREQEGQVREQEGQVREQEG 143

Query: 91  KENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDD 150
           +    E  + E++    E   ++  +  +  E E Q   +E +      +         +
Sbjct: 144 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGE 203

Query: 151 YETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTG 210
            E Q   + +    Q   M E+  +    +      EEQ   Q         +++ K   
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE--------EQVQKQEE 255

Query: 211 PNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKE 270
              ++ E+M E+++   + E+ + K      ++   GE     EE++  Q +E++R+ +E
Sbjct: 256 QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ----EEQMREQ-EEQMREQEE 310

Query: 271 NI-EKNEQINDEMKRSGQLGIQEEDLRKESKDQL 303
            + E+ EQ+ ++ +   Q+G QEE +  E K+Q+
Sbjct: 311 QMREQEEQMREQEE---QMGKQEEQM-WEQKEQM 340



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 57/305 (18%), Positives = 122/305 (40%), Gaps = 30/305 (9%)

Query: 31  QRNQLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQ 90
           Q  Q+ ++E  +R +  Q       +R  E    +R+Q  +          Q   V  Q+
Sbjct: 134 QEGQVREQEGQVREQEGQVREQEGQVREQE--GQVREQEGQVREQEGQVREQEGQVREQE 191

Query: 91  KENGD-ESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSD 149
            + G+ E  + E++    E   ++  +  +  E E Q   +E +   +  ++       +
Sbjct: 192 GQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQ---MGEQEEQVQKQEE 248

Query: 150 DYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLT 209
             + Q+   RK          EE  R+   +   +  EEQ   Q   T +   ++ G+  
Sbjct: 249 QVQKQEEQMRK---------QEEQMREQEEQMREQ--EEQMLKQKEQTEQE--EQTGEQE 295

Query: 210 GPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSK 269
               ++ E+M E+++   + E+ + +      E+ +G ++    E+K +   Q+E    +
Sbjct: 296 EQMREQEEQMREQEEQMREQEEQMREQ-----EEQMGKQEEQMWEQKEQMWEQKEQMWKQ 350

Query: 270 ENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNG 329
           E  +  EQ     K+  Q+  QEE +RK+      + + K    +++     G  + Q G
Sbjct: 351 EE-QMGEQEEQMQKQEEQVRKQEEQMRKQ-----EEQMRKQEEQMRKQEEQMGEQKEQMG 404

Query: 330 QNGER 334
           +  E+
Sbjct: 405 EQKEQ 409


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 47/225 (20%), Positives = 100/225 (44%), Gaps = 19/225 (8%)

Query: 179  FKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANN 238
            F +   +++   T + +AT++  FQ+       +  KR+ ++E+      +++D+     
Sbjct: 834  FFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ 893

Query: 239  IAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKE 298
               E+++  E+      K + Q + ++++  E  E  E+IN E+    +   + ED   E
Sbjct: 894  AESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKR---KLEDECSE 950

Query: 299  SKDQLSDDVSKVIAYLKRLVNAAGSGRLQN------GQNGERATRLFEKPLDSQSIYQLI 352
             K  + DD+   +A +++  +A    +++N      G +   A    EK    ++  Q +
Sbjct: 951  LKKDI-DDLELTLAKVEKEKHAT-ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAL 1008

Query: 353  EISRNLQIPPEDLIEMLKTGEKPNGSVEP-----ERELDLPVDLD 392
            +   +LQ   + +  + KT  K    VE      E+E  L VDL+
Sbjct: 1009 D---DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLE 1050


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 59/283 (20%), Positives = 111/283 (39%), Gaps = 29/283 (10%)

Query: 34   QLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVP-----L 88
            Q L KE D   + +++ P P      + +E  +++  KE+   D +  Q    P      
Sbjct: 1304 QSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDT 1363

Query: 89   QQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMS 148
                +G  S L E  SL   D  + IL+ L++     +S+P              P D++
Sbjct: 1364 GYSSDGISSSLGEIPSLIPTD-EKDILKGLKKDSFSQESSPSS------------PSDLA 1410

Query: 149  DDYETQQWPERKLKHMQFPPMYEENS--RDNPFKRTNEIVEEQYTPQSLA-TLESVFQEL 205
                T       +   Q   + +E S  +  P + + E  ++Q   QSL+ TLE    E 
Sbjct: 1411 KLEST----VLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISE- 1465

Query: 206  GKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEV 265
             ++     ++++   ++ +       D  + +    +     E ++ VEE  ES+    V
Sbjct: 1466 EEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESE-NSPV 1524

Query: 266  RDSKENIEKNEQINDEMKRSGQLGIQEED--LRKESKDQLSDD 306
               K         +DE K+    G  EE+  +RK+  +  +D+
Sbjct: 1525 PQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADE 1567


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 59/283 (20%), Positives = 111/283 (39%), Gaps = 29/283 (10%)

Query: 34   QLLQKEPDLRLENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVP-----L 88
            Q L KE D   + +++ P P      + +E  +++  KE+   D +  Q    P      
Sbjct: 1304 QSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDT 1363

Query: 89   QQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMS 148
                +G  S L E  SL   D  + IL+ L++     +S+P              P D++
Sbjct: 1364 GYSSDGISSSLGEIPSLIPTD-EKDILKGLKKDSFSQESSPSS------------PSDLA 1410

Query: 149  DDYETQQWPERKLKHMQFPPMYEENS--RDNPFKRTNEIVEEQYTPQSLA-TLESVFQEL 205
                T       +   Q   + +E S  +  P + + E  ++Q   QSL+ TLE    E 
Sbjct: 1411 KLEST----VLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISE- 1465

Query: 206  GKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEV 265
             ++     ++++   ++ +       D  + +    +     E ++ VEE  ES+    V
Sbjct: 1466 EEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESE-NSPV 1524

Query: 266  RDSKENIEKNEQINDEMKRSGQLGIQEED--LRKESKDQLSDD 306
               K         +DE K+    G  EE+  +RK+  +  +D+
Sbjct: 1525 PQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADE 1567


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 38.5 bits (88), Expect = 0.018
 Identities = 113/535 (21%), Positives = 216/535 (40%), Gaps = 92/535 (17%)

Query: 59   LEYIENLRQQAHKEESSPDYNPYQGVSVPLQQKENGDESHLPERDSLSEEDWMRIILEAL 118
            LE +  L+ +  K  S  +  P    ++   Q++NG         SLS+ D M      L
Sbjct: 534  LETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL-----SLSQRDTM------L 582

Query: 119  RQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNP 178
            ++ E +  S  +E   + +N  KN   +M + ++  +  ER +  ++     E+  + N 
Sbjct: 583  KELEGKINSLTEEKDDF-INKLKNSHEEMDNFHKKCEREERLI--LELGKKVEQTIQYN- 638

Query: 179  FKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDED------- 231
                +E+  EQ   +    LE   +E  +    N+QK E++  + K+ ++D++       
Sbjct: 639  ----SEL--EQKVNELTGGLEETLKEKDQ----NDQKLEKLMVQMKVLSEDKEVLSAEVK 688

Query: 232  DIYKANN-----------------IAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEK 274
             +Y+ NN                    EDV+  E    +E+K++   +E+  D+   + +
Sbjct: 689  SLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQ--DNLNKLLE 746

Query: 275  NEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGER 334
            NEQ+     ++   G  +E   + S+D    DV  V+        A G    +   N E+
Sbjct: 747  NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVL-------QAVGESLAK--INEEK 797

Query: 335  ATRLFEKPLDSQSIYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDI 394
                F++        +++E+ + ++   E+ +   +  +      E E+ L L  +L++I
Sbjct: 798  CNLAFQRD------EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL-LRKELEEI 850

Query: 395  -SEADLDHPDLFQNRMLSKSGYPKTPGRAGTEALPDGLSVEDILNLLGMESAANQKTSYF 453
             SE +    DL +     K+   KT  R   + L   + VE++          N+K   F
Sbjct: 851  QSEKEALQSDLLE----MKNANEKT--RLENQNLL--IQVEEVSQTCSKSEIHNEKEKCF 902

Query: 454  PNPYNQEKVLPRLPYGAGRSRSNQL----PKAAWIPHVENRQM-AYENLNDKDQELGEYL 508
               +  E + P L     R R  +L       A  P V+N  + + + L +K + L +  
Sbjct: 903  IKEH--ENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC 960

Query: 509  ARMLVKYPEIINSNQVKRVPGQGSSEDDLQEEEQIEQAIKEHLNQGSSQETDKLA 563
                 K       N++K V  +   E D   +E   Q +KE L +    E D+L+
Sbjct: 961  KEKEEKI------NKIKLVAVKAKKELDSSRKE--TQTVKEEL-ESLRSEKDQLS 1006


>gi|21735569 claspin [Homo sapiens]
          Length = 1339

 Score = 38.5 bits (88), Expect = 0.018
 Identities = 32/127 (25%), Positives = 63/127 (49%), Gaps = 10/127 (7%)

Query: 193 QSLATLESVFQELGKLTG-PNNQKRE---RMDEEQKLYTDDEDDIYKANNIAYEDVVGGE 248
           + L  L++  QE  KL      QKR+   ++D E     ++E++      +  E    GE
Sbjct: 592 EKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEE----EEMTDESEEDGE 647

Query: 249 DWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEE-DLRKESKDQLSDDV 307
           +    EEK E   +EE ++ +E  E N++  + +  S ++  ++E ++ KE+ D  S ++
Sbjct: 648 EKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDG-SSEI 706

Query: 308 SKVIAYL 314
            K + +L
Sbjct: 707 GKAVGFL 713


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score = 38.5 bits (88), Expect = 0.018
 Identities = 34/149 (22%), Positives = 68/149 (45%), Gaps = 9/149 (6%)

Query: 155 QWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQ 214
           QW  R    ++  P      +  P  +++E+ EE      +A L+    +L K    +  
Sbjct: 827 QWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEE------VAGLKEECAQLQKALEKSEF 880

Query: 215 KRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEK 274
           +RE +  +Q   T +++D+        E +   E+      K + Q +  V++  E +E+
Sbjct: 881 QREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEE 940

Query: 275 NEQINDEMKRSGQLGIQEE--DLRKESKD 301
            E+IN E+   G+  +++E  +L+KE  D
Sbjct: 941 EEEINSELTARGR-KLEDECFELKKEIDD 968



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 25/95 (26%), Positives = 51/95 (53%), Gaps = 8/95 (8%)

Query: 256  KIESQTQEEVRDSKENIE-KNEQINDEMKRSGQLGIQEEDLRKESKD--QLSDDVSKVIA 312
            +++ + +E++ + +  +   N Q+++  K  GQL IQ +DL+ +  D  QL+ D+ + +A
Sbjct: 1625 RLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVA 1684

Query: 313  YLKRLVNAAGSGRLQN----GQNGERATRLFEKPL 343
              +R  N+     L++     +  ER  RL E+ L
Sbjct: 1685 VAERR-NSLLQSELEDLRSLQEQTERGRRLSEEEL 1718


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 38.1 bits (87), Expect = 0.024
 Identities = 65/288 (22%), Positives = 113/288 (39%), Gaps = 57/288 (19%)

Query: 72   EESSPDYNPYQGVSVPLQQKEN--GDESHLPERDSLSEEDWMRIILEALRQAENEPQSAP 129
            E+ S D  P +G     +Q E   GDE                   EA  Q  +E  S  
Sbjct: 1250 EDGSSDDEPEEGKKRTGKQNEENPGDE-------------------EAKNQVNSESDSDS 1290

Query: 130  KENK-PYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEE 188
            +E+K P   +      + +SD    +   E+K K    P  ++E    N  K ++E  E+
Sbjct: 1291 EESKKPRYRHRLLRHKLTVSDG---ESGEEKKTK----PKEHKEVKGRNRRKVSSEDSED 1343

Query: 189  QYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGE 248
                +S  + E    E  +     + K+  ++E Q+ Y   +    K   I  ++    E
Sbjct: 1344 SDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKK----KRRRIKVQEDSSSE 1399

Query: 249  DWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVS 308
            + +  EE+ E + +EE  + +E  E+ E  ND+ K  G+        RK+ +  L DD  
Sbjct: 1400 NKSNSEEE-EEEKEEEEEEEEEEEEEEEDENDDSKSPGK-------GRKKIRKILKDDKL 1451

Query: 309  KVIAYLKRLVNAAGSGRLQNG--QNGERATRLFEKPLDSQSIYQLIEI 354
            +                 QN   +  ER  R+ E+  + + + ++IEI
Sbjct: 1452 RT--------------ETQNALKEEEERRKRIAEREREREKLREVIEI 1485


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 38.1 bits (87), Expect = 0.024
 Identities = 65/288 (22%), Positives = 113/288 (39%), Gaps = 57/288 (19%)

Query: 72   EESSPDYNPYQGVSVPLQQKEN--GDESHLPERDSLSEEDWMRIILEALRQAENEPQSAP 129
            E+ S D  P +G     +Q E   GDE                   EA  Q  +E  S  
Sbjct: 1288 EDGSSDDEPEEGKKRTGKQNEENPGDE-------------------EAKNQVNSESDSDS 1328

Query: 130  KENK-PYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMYEENSRDNPFKRTNEIVEE 188
            +E+K P   +      + +SD    +   E+K K    P  ++E    N  K ++E  E+
Sbjct: 1329 EESKKPRYRHRLLRHKLTVSDG---ESGEEKKTK----PKEHKEVKGRNRRKVSSEDSED 1381

Query: 189  QYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGE 248
                +S  + E    E  +     + K+  ++E Q+ Y   +    K   I  ++    E
Sbjct: 1382 SDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKK----KRRRIKVQEDSSSE 1437

Query: 249  DWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVS 308
            + +  EE+ E + +EE  + +E  E+ E  ND+ K  G+        RK+ +  L DD  
Sbjct: 1438 NKSNSEEE-EEEKEEEEEEEEEEEEEEEDENDDSKSPGK-------GRKKIRKILKDDKL 1489

Query: 309  KVIAYLKRLVNAAGSGRLQNG--QNGERATRLFEKPLDSQSIYQLIEI 354
            +                 QN   +  ER  R+ E+  + + + ++IEI
Sbjct: 1490 RT--------------ETQNALKEEEERRKRIAEREREREKLREVIEI 1523


>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
           sapiens]
          Length = 1188

 Score = 38.1 bits (87), Expect = 0.024
 Identities = 84/400 (21%), Positives = 157/400 (39%), Gaps = 59/400 (14%)

Query: 86  VPLQQKENGDESHLPERDS--LSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNF 143
           V  + +EN D +   ER+   L      R I   +   + E +    E+K    ++E   
Sbjct: 443 VKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENK- 501

Query: 144 PMDMSDDYETQQWPERKLK-HMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVF 202
             D+ DDYET +  E +L    +  P  +E           +  EE+   Q     ES  
Sbjct: 502 --DVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKC 559

Query: 203 QELGK---------LTGPNNQKRERMDEEQKLYT--------DDEDDIYKAN----NIAY 241
              G+         LTG   + +    + QK+Y         DD + +Y  +    N+ Y
Sbjct: 560 DSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRY 619

Query: 242 EDVVGGED--WNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKES 299
           ++ V  +   W P+++    + Q++   +KE+ EK+E+ ++E ++S           K  
Sbjct: 620 DEWVKADRIIW-PLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKS-----------KRG 667

Query: 300 KDQLSDDVSKVIAY-LKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNL 358
           +  L   +S  + Y L +  N+   G+  +  +        EK L ++ +    E+ +N 
Sbjct: 668 RPPLKSTLSSNMPYGLSKTANS--EGKSDSCSSDSETEDALEKNLINEELSLKDELEKNE 725

Query: 359 QIPPEDLIEMLKTGEKPNGSV----EPERELDLPVDLDDISEADLDH-PDLFQNRMLS-- 411
            +  + L E     E P  S     E +R    P++   +   + +    +F N+M    
Sbjct: 726 NLNDDKLDE-----ENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780

Query: 412 --KSGYPKTPGRAGTEALPDGLSVEDI-LNLLGMESAANQ 448
             K    K+P   G  +    LS+E I ++  G   A ++
Sbjct: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSE 820



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 76/345 (22%), Positives = 137/345 (39%), Gaps = 48/345 (13%)

Query: 89  QQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPM--- 145
           +QK+        E+D   +E+  +      ++     +S    N PY L+   N      
Sbjct: 640 KQKKKAKNKEDSEKDEKRDEERQKS-----KRGRPPLKSTLSSNMPYGLSKTANSEGKSD 694

Query: 146 DMSDDYETQQWPERKL--KHMQFPPMYEENSRDNPFKRTNE-------IVEEQYTPQSLA 196
             S D ET+   E+ L  + +      E+N   N  K   E       I++E    Q + 
Sbjct: 695 SCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQ-MQ 753

Query: 197 TLESVFQELGK------LTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVV---GG 247
            LE++  E+G+      + G   +K E + +E +     +    K  +++ E +     G
Sbjct: 754 PLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFG 813

Query: 248 EDWNPVEEKIESQTQE-EVRDSKENIEKNEQINDEMKRSGQL-------GIQEEDLRKES 299
           ++    E  IE+ + E    D+K      E   D+  +  +L          E+ +R E+
Sbjct: 814 QNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIEN 873

Query: 300 KDQLSDDVSKVIAYLKRLVNAAGSGRLQN---GQNGERATRLFEKPL--DSQSIYQLIEI 354
             ++++ VS+     +R  +  GS  ++N    Q+ ER        +   +Q I QL   
Sbjct: 874 GMEMTNTVSQ-----ERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLT-- 926

Query: 355 SRNLQIPPEDLIEM-LKTGEKPNGSVEPERELDLPVDLDDISEAD 398
           S     P E+ + + LK  E     + PE  +   VDLDD+ E D
Sbjct: 927 SERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKD 971


>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
           sapiens]
          Length = 1203

 Score = 38.1 bits (87), Expect = 0.024
 Identities = 84/400 (21%), Positives = 157/400 (39%), Gaps = 59/400 (14%)

Query: 86  VPLQQKENGDESHLPERDS--LSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNF 143
           V  + +EN D +   ER+   L      R I   +   + E +    E+K    ++E   
Sbjct: 443 VKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENK- 501

Query: 144 PMDMSDDYETQQWPERKLK-HMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVF 202
             D+ DDYET +  E +L    +  P  +E           +  EE+   Q     ES  
Sbjct: 502 --DVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKC 559

Query: 203 QELGK---------LTGPNNQKRERMDEEQKLYT--------DDEDDIYKAN----NIAY 241
              G+         LTG   + +    + QK+Y         DD + +Y  +    N+ Y
Sbjct: 560 DSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRY 619

Query: 242 EDVVGGED--WNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKES 299
           ++ V  +   W P+++    + Q++   +KE+ EK+E+ ++E ++S           K  
Sbjct: 620 DEWVKADRIIW-PLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKS-----------KRG 667

Query: 300 KDQLSDDVSKVIAY-LKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNL 358
           +  L   +S  + Y L +  N+   G+  +  +        EK L ++ +    E+ +N 
Sbjct: 668 RPPLKSTLSSNMPYGLSKTANS--EGKSDSCSSDSETEDALEKNLINEELSLKDELEKNE 725

Query: 359 QIPPEDLIEMLKTGEKPNGSV----EPERELDLPVDLDDISEADLDH-PDLFQNRMLS-- 411
            +  + L E     E P  S     E +R    P++   +   + +    +F N+M    
Sbjct: 726 NLNDDKLDE-----ENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780

Query: 412 --KSGYPKTPGRAGTEALPDGLSVEDI-LNLLGMESAANQ 448
             K    K+P   G  +    LS+E I ++  G   A ++
Sbjct: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSE 820



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 76/345 (22%), Positives = 137/345 (39%), Gaps = 48/345 (13%)

Query: 89  QQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPM--- 145
           +QK+        E+D   +E+  +      ++     +S    N PY L+   N      
Sbjct: 640 KQKKKAKNKEDSEKDEKRDEERQKS-----KRGRPPLKSTLSSNMPYGLSKTANSEGKSD 694

Query: 146 DMSDDYETQQWPERKL--KHMQFPPMYEENSRDNPFKRTNE-------IVEEQYTPQSLA 196
             S D ET+   E+ L  + +      E+N   N  K   E       I++E    Q + 
Sbjct: 695 SCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQ-MQ 753

Query: 197 TLESVFQELGK------LTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVV---GG 247
            LE++  E+G+      + G   +K E + +E +     +    K  +++ E +     G
Sbjct: 754 PLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFG 813

Query: 248 EDWNPVEEKIESQTQE-EVRDSKENIEKNEQINDEMKRSGQL-------GIQEEDLRKES 299
           ++    E  IE+ + E    D+K      E   D+  +  +L          E+ +R E+
Sbjct: 814 QNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIEN 873

Query: 300 KDQLSDDVSKVIAYLKRLVNAAGSGRLQN---GQNGERATRLFEKPL--DSQSIYQLIEI 354
             ++++ VS+     +R  +  GS  ++N    Q+ ER        +   +Q I QL   
Sbjct: 874 GMEMTNTVSQ-----ERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLT-- 926

Query: 355 SRNLQIPPEDLIEM-LKTGEKPNGSVEPERELDLPVDLDDISEAD 398
           S     P E+ + + LK  E     + PE  +   VDLDD+ E D
Sbjct: 927 SERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKD 971


>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
           sapiens]
          Length = 1257

 Score = 38.1 bits (87), Expect = 0.024
 Identities = 84/400 (21%), Positives = 157/400 (39%), Gaps = 59/400 (14%)

Query: 86  VPLQQKENGDESHLPERDS--LSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNF 143
           V  + +EN D +   ER+   L      R I   +   + E +    E+K    ++E   
Sbjct: 443 VKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENK- 501

Query: 144 PMDMSDDYETQQWPERKLK-HMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVF 202
             D+ DDYET +  E +L    +  P  +E           +  EE+   Q     ES  
Sbjct: 502 --DVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKC 559

Query: 203 QELGK---------LTGPNNQKRERMDEEQKLYT--------DDEDDIYKAN----NIAY 241
              G+         LTG   + +    + QK+Y         DD + +Y  +    N+ Y
Sbjct: 560 DSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRY 619

Query: 242 EDVVGGED--WNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKES 299
           ++ V  +   W P+++    + Q++   +KE+ EK+E+ ++E ++S           K  
Sbjct: 620 DEWVKADRIIW-PLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKS-----------KRG 667

Query: 300 KDQLSDDVSKVIAY-LKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNL 358
           +  L   +S  + Y L +  N+   G+  +  +        EK L ++ +    E+ +N 
Sbjct: 668 RPPLKSTLSSNMPYGLSKTANS--EGKSDSCSSDSETEDALEKNLINEELSLKDELEKNE 725

Query: 359 QIPPEDLIEMLKTGEKPNGSV----EPERELDLPVDLDDISEADLDH-PDLFQNRMLS-- 411
            +  + L E     E P  S     E +R    P++   +   + +    +F N+M    
Sbjct: 726 NLNDDKLDE-----ENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780

Query: 412 --KSGYPKTPGRAGTEALPDGLSVEDI-LNLLGMESAANQ 448
             K    K+P   G  +    LS+E I ++  G   A ++
Sbjct: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSE 820



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 76/345 (22%), Positives = 137/345 (39%), Gaps = 48/345 (13%)

Query: 89  QQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPM--- 145
           +QK+        E+D   +E+  +      ++     +S    N PY L+   N      
Sbjct: 640 KQKKKAKNKEDSEKDEKRDEERQKS-----KRGRPPLKSTLSSNMPYGLSKTANSEGKSD 694

Query: 146 DMSDDYETQQWPERKL--KHMQFPPMYEENSRDNPFKRTNE-------IVEEQYTPQSLA 196
             S D ET+   E+ L  + +      E+N   N  K   E       I++E    Q + 
Sbjct: 695 SCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQ-MQ 753

Query: 197 TLESVFQELGK------LTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVV---GG 247
            LE++  E+G+      + G   +K E + +E +     +    K  +++ E +     G
Sbjct: 754 PLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFG 813

Query: 248 EDWNPVEEKIESQTQE-EVRDSKENIEKNEQINDEMKRSGQL-------GIQEEDLRKES 299
           ++    E  IE+ + E    D+K      E   D+  +  +L          E+ +R E+
Sbjct: 814 QNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIEN 873

Query: 300 KDQLSDDVSKVIAYLKRLVNAAGSGRLQN---GQNGERATRLFEKPL--DSQSIYQLIEI 354
             ++++ VS+     +R  +  GS  ++N    Q+ ER        +   +Q I QL   
Sbjct: 874 GMEMTNTVSQ-----ERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLT-- 926

Query: 355 SRNLQIPPEDLIEM-LKTGEKPNGSVEPERELDLPVDLDDISEAD 398
           S     P E+ + + LK  E     + PE  +   VDLDD+ E D
Sbjct: 927 SERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKD 971


>gi|52856430 protein expressed in prostate, ovary, testis, and
           placenta 15 [Homo sapiens]
          Length = 581

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 51/236 (21%), Positives = 96/236 (40%), Gaps = 30/236 (12%)

Query: 60  EYIENLRQQAHKEESSPDYNPYQGVSVPLQQKENG---DESHLPERDSLSEE---DWMRI 113
           E + + +++   + SS + NP Q + +  +++       E+  PE+ S   E   D  R 
Sbjct: 355 ELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDRE 414

Query: 114 ILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMY-EE 172
           + E +++  + P   P+       N          DD    Q   RK ++ QFP    EE
Sbjct: 415 VEEEIKKHGSNPVGLPE-------NLTNGASAGNGDDGLIPQRKSRKPENQQFPDTENEE 467

Query: 173 NSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQ---KRERMDEEQKLYTDD 229
              D       ++ EEQ T  S   +         LT    Q     + M+ +  L    
Sbjct: 468 YHSDEQNDTQKQLSEEQNTGISQDEI---------LTNKQKQIEVAEKEMNSKLSLSHKK 518

Query: 230 EDDIYKANNIAYEDV----VGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDE 281
           E+D+ + N++  E++    +  ++     +  E++  EE+   KE + K  Q+N+E
Sbjct: 519 EEDLLRENSMLREEIAMLRLELDETKHQNQLRENKILEEIESVKEKLLKAIQLNEE 574


>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
          Length = 709

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 70/366 (19%), Positives = 149/366 (40%), Gaps = 36/366 (9%)

Query: 122 ENEPQSAPKENKPYALNSEKNFPMDMSDDYET-QQWPERKLKHMQFPPMYEENSRDNPFK 180
           +NE     + NK   L++++   +  S   E  +  PE+     + P    ++   +  +
Sbjct: 96  KNEEYQRSERNK--RLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSE 153

Query: 181 RTNEIVEEQYTPQSLATLESV-FQELGK-----LTGPNNQKRERMDEEQKLYTDDEDDIY 234
           R    V+ + +  S ++ E V  +E G       +G ++++    + E++   +D ++  
Sbjct: 154 RIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDE 213

Query: 235 KANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEED 294
           +    A ED    ED    EE+ E + +EE    +E  E+ EQ   + K  G     + D
Sbjct: 214 EVEEDAEEDEEVDEDGEEEEEEEEEEEEEE----EEEEEEYEQDERDQKEEGN----DYD 265

Query: 295 LRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATR--LFEKPLDSQSIYQLI 352
            R E+ D  S+ VS     ++      GS   +  +   R     +F++   S S     
Sbjct: 266 TRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAD 325

Query: 353 EISRNLQIPPEDLIEMLKTGEKPNGSVEPEREL--DLPVDLDDISEADLDHPDLFQNRML 410
           + S+   +  +    ++K+    N S+   + +   LPV+   ++ A      +     +
Sbjct: 326 QTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSV 385

Query: 411 SKSGYPKTPGRAGTEA----------LPDGLSVEDILNLLGMESAANQ-----KTSYFPN 455
            +SG  +   R  +E+          LP G+S + +  +  ++    +     K+++  N
Sbjct: 386 RESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTN 445

Query: 456 PYNQEK 461
           P+N+ K
Sbjct: 446 PWNEHK 451


>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member B [Homo sapiens]
          Length = 251

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 33/121 (27%), Positives = 56/121 (46%), Gaps = 21/121 (17%)

Query: 187 EEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVG 246
           E+Q  P S A ++ V +E     G + +  +  D E++ + +++D+         EDV G
Sbjct: 151 EDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDED--------EDVEG 202

Query: 247 GEDWNPV-EEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSD 305
            ED + V EE+ E    EE  D  E+ E+ E            G + E  ++E+ D+  D
Sbjct: 203 DEDDDEVSEEEEEFGLDEEDEDEDEDEEEEE------------GGKGEKRKRETDDEGED 250

Query: 306 D 306
           D
Sbjct: 251 D 251


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
           sapiens]
          Length = 1941

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 24/124 (19%), Positives = 59/124 (47%), Gaps = 1/124 (0%)

Query: 179 FKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANN 238
           F +   +++   T + +AT++  FQ++      +  KR+ ++E+      +++D+     
Sbjct: 839 FFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ 898

Query: 239 IAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEM-KRSGQLGIQEEDLRK 297
              E +   E+      K + Q + ++++  E  E  E+IN E+  +  +L  +  +L+K
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958

Query: 298 ESKD 301
           +  D
Sbjct: 959 DIDD 962


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.129    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,229,599
Number of Sequences: 37866
Number of extensions: 1267678
Number of successful extensions: 5562
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 284
Number of HSP's that attempted gapping in prelim test: 4811
Number of HSP's gapped (non-prelim): 816
length of query: 617
length of database: 18,247,518
effective HSP length: 108
effective length of query: 509
effective length of database: 14,157,990
effective search space: 7206416910
effective search space used: 7206416910
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.