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Search of human proteins with 5902122
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
(2390 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 4718 0.0
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 2982 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 2748 0.0
gi|67782321 spectrin beta isoform a [Homo sapiens] 2427 0.0
gi|67782319 spectrin beta isoform b [Homo sapiens] 2303 0.0
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 1962 0.0
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 936 0.0
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 565 e-160
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 558 e-158
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 531 e-150
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 483 e-136
gi|12025678 actinin, alpha 4 [Homo sapiens] 444 e-124
gi|4501893 actinin, alpha 2 [Homo sapiens] 431 e-120
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 431 e-120
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 430 e-120
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 429 e-119
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 427 e-119
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 427 e-119
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 427 e-119
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 427 e-119
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 427 e-119
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 427 e-119
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 427 e-119
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 427 e-119
gi|4557241 actinin, alpha 3 [Homo sapiens] 422 e-117
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 351 6e-96
gi|221316624 dystonin isoform 4 [Homo sapiens] 315 4e-85
gi|221316622 dystonin isoform 3 [Homo sapiens] 315 4e-85
gi|221316618 dystonin isoform 2 [Homo sapiens] 315 4e-85
gi|34577047 dystonin isoform 1 [Homo sapiens] 312 2e-84
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 4718 bits (12238), Expect = 0.0
Identities = 2390/2390 (100%), Positives = 2390/2390 (100%)
Query: 1 MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQK 60
MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQK
Sbjct: 1 MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQK 60
Query: 61 KTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVD 120
KTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVD
Sbjct: 61 KTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVD 120
Query: 121 KALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKD 180
KALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKD
Sbjct: 121 KALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKD 180
Query: 181 ALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNA 240
ALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNA
Sbjct: 181 ALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNA 240
Query: 241 FNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHA 300
FNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHA
Sbjct: 241 FNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHA 300
Query: 301 MEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFT 360
MEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFT
Sbjct: 301 MEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFT 360
Query: 361 EKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQ 420
EKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQ
Sbjct: 361 EKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQ 420
Query: 421 EKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGR 480
EKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGR
Sbjct: 421 EKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGR 480
Query: 481 VQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDL 540
VQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDL
Sbjct: 481 VQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDL 540
Query: 541 LYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNP 600
LYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNP
Sbjct: 541 LYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNP 600
Query: 601 GKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQ 660
GKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQ
Sbjct: 601 GKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQ 660
Query: 661 QHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASA 720
QHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASA
Sbjct: 661 QHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASA 720
Query: 721 RAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
RAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF
Sbjct: 721 RAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
Query: 781 STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQAR 840
STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQAR
Sbjct: 781 STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQAR 840
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE
Sbjct: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI
Sbjct: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTR 1020
QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTR
Sbjct: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTR 1020
Query: 1021 EANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAW 1080
EANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAW
Sbjct: 1021 EANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAW 1080
Query: 1081 LGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQC 1140
LGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQC
Sbjct: 1081 LGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQC 1140
Query: 1141 LFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
LFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM
Sbjct: 1141 LFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
Query: 1201 PGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRH 1260
PGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRH
Sbjct: 1201 PGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRH 1260
Query: 1261 KKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQ 1320
KKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQ
Sbjct: 1261 KKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQ 1320
Query: 1321 AFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLF 1380
AFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLF
Sbjct: 1321 AFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLF 1380
Query: 1381 DANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE 1440
DANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE
Sbjct: 1381 DANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE 1440
Query: 1441 AIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDE 1500
AIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDE
Sbjct: 1441 AIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDE 1500
Query: 1501 ILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAG 1560
ILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAG
Sbjct: 1501 ILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAG 1560
Query: 1561 PELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDE 1620
PELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDE
Sbjct: 1561 PELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDE 1620
Query: 1621 LSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK 1680
LSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK
Sbjct: 1621 LSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK 1680
Query: 1681 ELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFS 1740
ELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFS
Sbjct: 1681 ELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFS 1740
Query: 1741 RDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAA 1800
RDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAA
Sbjct: 1741 RDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAA 1800
Query: 1801 YELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQ 1860
YELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQ
Sbjct: 1801 YELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQ 1860
Query: 1861 DDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELM 1920
DDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELM
Sbjct: 1861 DDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELM 1920
Query: 1921 LWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYA 1980
LWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYA
Sbjct: 1921 LWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYA 1980
Query: 1981 AEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAE 2040
AEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAE
Sbjct: 1981 AEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAE 2040
Query: 2041 LGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPA 2100
LGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPA
Sbjct: 2041 LGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPA 2100
Query: 2101 PEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEH 2160
PEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEH
Sbjct: 2101 PEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEH 2160
Query: 2161 SSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQ 2220
SSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQ
Sbjct: 2161 SSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQ 2220
Query: 2221 MEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLAR 2280
MEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLAR
Sbjct: 2221 MEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLAR 2280
Query: 2281 AQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEP 2340
AQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEP
Sbjct: 2281 AQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEP 2340
Query: 2341 VVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK 2390
VVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK
Sbjct: 2341 VVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK 2390
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 2982 bits (7731), Expect = 0.0
Identities = 1494/2400 (62%), Positives = 1866/2400 (77%), Gaps = 49/2400 (2%)
Query: 3 STLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKT 62
+T TD+D++EIQ QYSD+NNRWD+ DWDN++SSARLFERSRIKALADEREAVQKKT
Sbjct: 2 TTTVATDYDNIEIQQQYSDVNNRWDV--DDWDNENSSARLFERSRIKALADEREAVQKKT 59
Query: 63 FTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKA 122
FTKWVNSHLARV+CR+ DLY+DLRDGR L++LLEVLSGE LPKPTKGRMRIHCLENVDKA
Sbjct: 60 FTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKA 119
Query: 123 LQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDAL 182
LQFLKEQ+VHLENMGSHDIVDGNHRLTLGL+WTIILRFQIQDISVETEDNKEKKSAKDAL
Sbjct: 120 LQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDAL 179
Query: 183 LLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFN 242
LLWCQMKTAGYPNVN+HNFTTSWRDG+AFNA++HKHRPDL+DF+ LKK NAHYNLQNAFN
Sbjct: 180 LLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFN 239
Query: 243 LAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAME 302
LAE+ LGLTKLLDPED++VD PDEKSIITYV TYYHYFSKMKALAVEGKRIGKVLD+A+E
Sbjct: 240 LAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIE 299
Query: 303 AERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEK 362
E+++EKYESLAS+LL+WIEQTI+ LN+R+ ANSL GVQ QLQ+FN+YRTVEKPPKFTEK
Sbjct: 300 TEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEK 359
Query: 363 GNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEK 422
GNLEVLLFTIQSK+RANNQKVY PREG+LISDINKAWERLEKAEHERELALR ELIRQEK
Sbjct: 360 GNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEK 419
Query: 423 LEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQ 482
LEQLA RFDRKAAMRETWLSENQRLVSQDNFG +L AVEAA +KHEAIETDI AY RVQ
Sbjct: 420 LEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQ 479
Query: 483 AVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLY 542
AV AVA EL AE YHDIKRI AR+ NV RLW++L +++ ARR+RL +NL LQK+FQ++LY
Sbjct: 480 AVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY 539
Query: 543 LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGK 602
+MDWM+EMK + SQD G+HL GVEDLLQ H LVEADI +QAERVR V+ASA +F G+
Sbjct: 540 IMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGE 599
Query: 603 EYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQH 662
Y+PCDPQ++ +RVA +E Y+ LC+LAA RRARLEESRRLW+F WE+ E E W+RE++
Sbjct: 600 GYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEK 659
Query: 663 LLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARA 722
+L+S D G+DLT +RLL+KH A EMSGR G + +++G+ ++AE H G+ + R
Sbjct: 660 ILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERI 719
Query: 723 AELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFST 782
++ QW LE L+ R +RL +A+ L+QFQADA+D++AW++D L++VSS ++GHDE+ST
Sbjct: 720 IYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYST 779
Query: 783 QALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAG 842
Q+L ++H+ + EEI ++RPTLD L EQA+ALP + +P+V+GR+ +E Y+E+
Sbjct: 780 QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTR 839
Query: 843 ERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMN 902
R +AL+ LALY M SEA AC LW++EKEQWLN + +PE+LEDLEV+Q RFE+LEPEMN
Sbjct: 840 LRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMN 899
Query: 903 TLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN 962
A+++ VN IA QL+ + P + I Q++LN RW QFR L D KK AL SALSIQN
Sbjct: 900 NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQN 959
Query: 963 YHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREA 1022
YHLEC ET++W+REKTKVIESTQ LGNDLAGV+ALQRKL G ERDL AI A++ +L +EA
Sbjct: 960 YHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEA 1019
Query: 1023 NALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLG 1082
L + HP QA AI +RL E+ WE+++ T++ RE SLGEA +LQ FLR LDDFQ+WL
Sbjct: 1020 EKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS 1079
Query: 1083 RTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF 1142
RTQTA+ASE+ P TL EAE LL QH ++ E++ + +Y ++R +GE VT+ Q D Q +F
Sbjct: 1080 RTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMF 1139
Query: 1143 LRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
LRQRL+AL TGW EL +MWE+RQ L+Q+H +Q FLRD +QAE L++QEYVL+HTEMP
Sbjct: 1140 LRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPT 1199
Query: 1203 TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKK 1262
TL+ A+AAIKK EDFM+TMDAN E+I+ ++E GR+LVS+GNI++D+I+EK DSI+ RH+K
Sbjct: 1200 TLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRK 1259
Query: 1263 NQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAF 1322
N++ A + L RL+DNR+ Q FLQDC EL LWI+EKMLTAQD+SYDEARNLH+KW KHQAF
Sbjct: 1260 NRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAF 1319
Query: 1323 MAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDA 1382
MAELA+NK+WLDK++KEG +L EKPE +A+V EKL LH+ W+ LE+TTQ KA+ LFDA
Sbjct: 1320 MAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA 1379
Query: 1383 NRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAI 1442
N+AELF QSC L+ WL L++Q+ SDDYGKDLTSVNILLKKQQMLE +M VR+KE+E +
Sbjct: 1380 NKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEEL 1439
Query: 1443 QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEIL 1502
Q+QA+AL+QE + EV+ V+ KF L +P+ ER L AS+E HQF+RDVEDEIL
Sbjct: 1440 QSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL 1499
Query: 1503 WVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQR-------ALG 1555
WV ER+P+A+S +HG +L +VQLL+KKNQTLQKEIQGH+PRI D+ ER + +L
Sbjct: 1500 WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS 1559
Query: 1556 AAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQE 1615
A A LA+L+++W L E E R +RLE+A RAQQ+Y DAAEAEAWM EQEL+MM +E
Sbjct: 1560 AEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEE 1619
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKL 1675
KAKDE SA + +KKHQ+LEQA+ DYA+T+HQL+ +S+ ++ HPES RIS+RQ++VDKL
Sbjct: 1620 KAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKL 1679
Query: 1676 YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDK 1735
YAGLK+LA ERR +L E RL QL RE+DDLEQWI EREVVA SHELGQDYEHVTML+++
Sbjct: 1680 YAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQER 1739
Query: 1736 FREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQ 1795
FREF+RDT IGQERVD+ N LA+ LI GH+ AT+AEWKD LNEAWADLLEL+DTR Q
Sbjct: 1740 FREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQ 1799
Query: 1796 VLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQ 1855
+LAA+YEL +F H A++ R+Q K ++LP+ GRD N E LQR H +EHDIQAL Q
Sbjct: 1800 ILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQ 1859
Query: 1856 VQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA 1915
V+Q+Q+D RLQ AYAGDKA++I + V EAW L + +RR L+DT DKFRFF
Sbjct: 1860 VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSM 1919
Query: 1916 VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLA 1975
VR+LMLWM++V Q++AQE+PRDVSS +L++ N QGIKAEI+AR D F++CI++GK LLA
Sbjct: 1920 VRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLA 1979
Query: 1976 RSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPL 2035
R HYA+EEI EKL QL +R+E +KW+++ +WL+L+LEV F RDA +AEAWL QEP
Sbjct: 1980 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPY 2039
Query: 2036 VRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERR 2095
+ S E+G +VDEVE LIKRHEAF+KSA W+ERF ALE+LT LE E +R++EEEER+
Sbjct: 2040 LSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEV--RRQQEEEERK 2097
Query: 2096 KQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNG---VCTDGEPSQPL 2152
++PP+PEP+ V + S WD ++ P+ G + + S+ +
Sbjct: 2098 RRPPSPEPSTK------VSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMV 2151
Query: 2153 LGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRG 2212
G SS P P P +R+ +T PA S AATLP R
Sbjct: 2152 NGATEQRTSSKESSPIP-------SPTSDRKAKTALPAQS------------AATLPART 2192
Query: 2213 PE-PSAQEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYH 2271
E PSA QMEG L RK E EA KKA++RSW NVYCV+ +GFYKDAK A++G+PYH
Sbjct: 2193 QETPSA--QMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYH 2250
Query: 2272 GEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATAS 2331
EVPVSL A VA DY+K+KHVFKL L DG EYLFQAKD+ EM++W++ +++AI
Sbjct: 2251 SEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAI---- 2306
Query: 2332 SASGEPEEPVVPSTTRGMTRAMTMP-PVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK 2390
+S + E +T +RA T+P V + +E R KD +E+++EKRFS F K K
Sbjct: 2307 -SSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKD-KEKDKEKRFSLFGKKK 2364
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 2748 bits (7124), Expect = 0.0
Identities = 1352/2102 (64%), Positives = 1681/2102 (79%), Gaps = 15/2102 (0%)
Query: 47 RIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKP 106
R K L DEREAVQKKTFTKWVNSHLARV+CR+ DLY+DLRDGR L++LLEVLSGE LPKP
Sbjct: 31 RFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKP 90
Query: 107 TKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDIS 166
TKGRMRIHCLENVDKALQFLKEQ+VHLENMGSHDIVDGNHRLTLGL+WTIILRFQIQDIS
Sbjct: 91 TKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDIS 150
Query: 167 VETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFE 226
VETEDNKEKKSAKDALLLWCQMKTAGYPNVN+HNFTTSWRDG+AFNA++HKHRPDL+DF+
Sbjct: 151 VETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFD 210
Query: 227 SLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKAL 286
LKK NAHYNLQNAFNLAE+ LGLTKLLDPED++VD PDEKSIITYV TYYHYFSKMKAL
Sbjct: 211 KLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKAL 270
Query: 287 AVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQS 346
AVEGKRIGKVLD+A+E E+++EKYESLAS+LL+WIEQTI+ LN+R+ ANSL GVQ QLQ+
Sbjct: 271 AVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQA 330
Query: 347 FNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAE 406
FN+YRTVEKPPKFTEKGNLEVLLFTIQSK+RANNQKVY PREG+LISDINKAWERLEKAE
Sbjct: 331 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAE 390
Query: 407 HERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRK 466
HERELALR ELIRQEKLEQLA RFDRKAAMRETWLSENQRLVSQDNFG +L AVEAA +K
Sbjct: 391 HERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK 450
Query: 467 HEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRER 526
HEAIETDI AY RVQAV AVA EL AE YHDIKRI AR+ NV RLW++L +++ ARR+R
Sbjct: 451 HEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQR 510
Query: 527 LLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAER 586
L +NL LQK+FQ++LY+MDWM+EMK + SQD G+HL GVEDLLQ H LVEADI +QAER
Sbjct: 511 LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAER 570
Query: 587 VRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRF 646
VR V+ASA +F G+ Y+PCDPQ++ +RVA +E Y+ LC+LAA RRARLEESRRLW+F
Sbjct: 571 VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKF 630
Query: 647 LWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQ 706
WE+ E E W+RE++ +L+S D G+DLT +RLL+KH A EMSGR G + +++G+
Sbjct: 631 FWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED 690
Query: 707 LVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDA 766
++AE H G+ + R ++ QW LE L+ R +RL +A+ L+QFQADA+D++AW++D
Sbjct: 691 MIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDI 750
Query: 767 LRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGR 826
L++VSS ++GHDE+STQ+L ++H+ + EEI ++RPTLD L EQA+ALP + +P+V+GR
Sbjct: 751 LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGR 810
Query: 827 VPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLED 886
+ +E Y+E+ R +AL+ LALY M SEA AC LW++EKEQWLN + +PE+LED
Sbjct: 811 LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED 870
Query: 887 LEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRL 946
LEV+Q RFE+LEPEMN A+++ VN IA QL+ + P + I Q++LN RW QFR L
Sbjct: 871 LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL 930
Query: 947 ADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTER 1006
D KK AL SALSIQNYHLEC ET++W+REKTKVIESTQ LGNDLAGV+ALQRKL G ER
Sbjct: 931 VDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 990
Query: 1007 DLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARR 1066
DL AI A++ +L +EA L + HP QA AI +RL E+ WE+++ T++ RE SLGEA +
Sbjct: 991 DLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASK 1050
Query: 1067 LQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRA 1126
LQ FLR LDDFQ+WL RTQTA+ASE+ P TL EAE LL QH ++ E++ + +Y ++R
Sbjct: 1051 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD 1110
Query: 1127 LGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEG 1186
+GE VT+ Q D Q +FLRQRL+AL TGW EL +MWE+RQ L+Q+H +Q FLRD +QAE
Sbjct: 1111 MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA 1170
Query: 1187 VLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHA 1246
L++QEYVL+HTEMP TL+ A+AAIKK EDFM+TMDAN E+I+ ++E GR+LVS+GNI++
Sbjct: 1171 FLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINS 1230
Query: 1247 DKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSY 1306
D+I+EK DSI+ RH+KN++ A + L RL+DNR+ Q FLQDC EL LWI+EKMLTAQD+SY
Sbjct: 1231 DRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY 1290
Query: 1307 DEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWD 1366
DEARNLH+KW KHQAFMAELA+NK+WLDK++KEG +L EKPE +A+V EKL LH+ W+
Sbjct: 1291 DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE 1350
Query: 1367 ELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQ 1426
LE+TTQ KA+ LFDAN+AELF QSC L+ WL L++Q+ SDDYGKDLTSVNILLKKQQ
Sbjct: 1351 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1410
Query: 1427 MLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQA 1486
MLE +M VR+KE+E +Q+QA+AL+QE + EV+ V+ KF L +P+ ER L A
Sbjct: 1411 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1470
Query: 1487 SREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIAD 1546
S+E HQF+RDVEDEILWV ER+P+A+S +HG +L +VQLL+KKNQTLQKEIQGH+PRI D
Sbjct: 1471 SKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD 1530
Query: 1547 LRERQR-------ALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
+ ER + +L A A LA+L+++W L E E R +RLE+A RAQQ+Y DAAE
Sbjct: 1531 IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE 1590
Query: 1600 AEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEH 1659
AEAWM EQEL+MM +EKAKDE SA + +KKHQ+LEQA+ DYA+T+HQL+ +S+ ++ H
Sbjct: 1591 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSH 1650
Query: 1660 PESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAAS 1719
PES RIS+RQ++VDKLYAGLK+LA ERR +L E RL QL RE+DDLEQWI EREVVA S
Sbjct: 1651 PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGS 1710
Query: 1720 HELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSL 1779
HELGQDYEHVTML+++FREF+RDT IGQERVD+ N LA+ LI GH+ AT+AEWKD L
Sbjct: 1711 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1770
Query: 1780 NEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQ 1839
NEAWADLLEL+DTR Q+LAA+YEL +F H A++ R+Q K ++LP+ GRD N E LQ
Sbjct: 1771 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ 1830
Query: 1840 RRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAAR 1899
R H +EHDIQAL QV+Q+Q+D RLQ AYAGDKA++I + V EAW L + +R
Sbjct: 1831 RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR 1890
Query: 1900 RQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR 1959
R L+DT DKFRFF VR+LMLWM++V Q++AQE+PRDVSS +L++ N QGIKAEI+AR
Sbjct: 1891 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1950
Query: 1960 ADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFG 2019
D F++CI++GK LLAR HYA+EEI EKL QL +R+E +KW+++ +WL+L+LEV F
Sbjct: 1951 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2010
Query: 2020 RDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALE 2079
RDA +AEAWL QEP + S E+G +VDEVE LIKRHEAF+KSA W+ERF ALE+LT LE
Sbjct: 2011 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2070
Query: 2080 EREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSV 2139
E +R++EEEER+++PP+PEP+ V + S WD ++ P+
Sbjct: 2071 LLEV--RRQQEEEERKRRPPSPEPSTK------VSEEAESQQQWDTSKGEQVSQNGLPAE 2122
Query: 2140 NG 2141
G
Sbjct: 2123 QG 2124
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 2427 bits (6291), Expect = 0.0
Identities = 1250/2392 (52%), Positives = 1659/2392 (69%), Gaps = 73/2392 (3%)
Query: 6 SPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTK 65
S T+F+++ Q YS IN RWD PD + DND+SSARLFERSRIKALADERE VQKKTFTK
Sbjct: 3 SATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTFTK 62
Query: 66 WVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQF 125
WVNSHLARV+CR+ DLY DLRDGR L++LLEVLSGE+LPKPTKG+MRIHCLENVDKALQF
Sbjct: 63 WVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQF 122
Query: 126 LKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLW 185
LKEQ+VHLENMGSHDIVDGNHRL LGL+WTIILRFQIQDI V+T++ +E +SAKDALLLW
Sbjct: 123 LKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLW 182
Query: 186 CQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAE 245
CQMKTAGYP+VNV NFT+SW+DGLAFNA++HKHRPDL+DF+ LK NA +NL++AFN+AE
Sbjct: 183 CQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAE 242
Query: 246 KELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAER 305
++LG+ LLDPEDV + PDEKSIITYV +YHYFSKMK LAVEGKR+GKV+DHA+E E+
Sbjct: 243 RQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEK 302
Query: 306 LVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNL 365
++EKY LAS+LL WIEQTI LN R+ ANSL+GVQ QLQ+F++YRTVEKPPKF EKGNL
Sbjct: 303 MIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNL 362
Query: 366 EVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQ 425
EVLLFTIQS++RANNQKVYTP +G+L+SDIN+AWE LE+AE+ RELALR ELIRQEKLEQ
Sbjct: 363 EVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQ 422
Query: 426 LAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVD 485
LA RFDRKAAMRETWLSENQRLV+QDNFG +LAAVEAA +KHEAIETD AY RV+A++
Sbjct: 423 LARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALE 482
Query: 486 AVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD 545
+A EL E YHD KRI AR+ N+ RLW +L++++ +RR+RL L LQK+FQD+L+ +D
Sbjct: 483 DLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSID 542
Query: 546 WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR 605
WM+E+K L S + G+HL VEDLLQ H+L+EADIA+Q ++V+A++A+ L+F GK Y+
Sbjct: 543 WMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTE-GKGYQ 601
Query: 606 PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665
PCDPQ++ +R++ LEQ +E L +AA R+A+LE+S+RLW+F WE+ EAE+W++E++ + +
Sbjct: 602 PCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYS 661
Query: 666 SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL 725
S D G+DLT L L KH A E+ G L+ ++ +VA G Q AR E+
Sbjct: 662 SLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEV 721
Query: 726 QAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL 785
AQW++L+ LA + L A + +QFQ DA+D++AWL DA RL+S ++G DE +T+AL
Sbjct: 722 SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRAL 781
Query: 786 ARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERA 845
++H+ EE+ R ++ L +QA P +P+V R+ L Y+++ A+A R
Sbjct: 782 GKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQ 841
Query: 846 RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLA 905
+ L+ AL LYT+ E AC LW+ EKE+WL + +P+ LEDLEVVQ RF+ L+ EM TL
Sbjct: 842 QRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLM 901
Query: 906 AQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHL 965
QI VN A L+++ P + Q+ LN RWQ F+ L ++ A+ SAL + NY +
Sbjct: 902 TQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCV 961
Query: 966 ECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL 1025
+C ET W+ +KTKV+EST+ LG DLAG++A+QRKL+G ERD+ AI ARV L RE+ L
Sbjct: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
Query: 1026 AAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQ 1085
HP Q I R + ++ W+ L+ +++ +E+ LGE +LQ FL+ LDDFQAWL TQ
Sbjct: 1022 MDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ 1081
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AVASE+ P +LPEAE LL QHA ++ E++ Q Y R++ GE+V + Q DP+ L L Q
Sbjct: 1082 KAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQ 1141
Query: 1146 RLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQ 1205
RLE L TGW LGRMWESR LAQ GFQ F +DA+QAE +LS+QEY L+H E P +L+
Sbjct: 1142 RLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLE 1201
Query: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQD 1265
AA+A I+K EDF+ +M+ N +++ +++G +LV+EGN+++DKI+EK IE RH+KN +
Sbjct: 1202 AAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNE 1261
Query: 1266 AAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAE 1325
AQ+ LRDN E Q+FLQ+C EL LWI++K+LT+QDVSYDEARNLH KW KHQAF+AE
Sbjct: 1262 KAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAE 1321
Query: 1326 LAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRA 1385
LA+++ WL+ +D EG++L EKP+ ALVS+KL LHR WDEL+ TT+ K + L A +
Sbjct: 1322 LASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSS 1381
Query: 1386 ELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQ 1445
+L Q+ L W+ +++ QL SDD GKDLTSVN +L K + +E ++ VR++E+ + AQ
Sbjct: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
Query: 1446 AKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVT 1505
++ +E A ++E++F L +P+ R ++L++SR + Q RD+EDE LWV
Sbjct: 1442 VPSMGEEGGDA------DLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
Query: 1506 ERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAA------ 1559
ERLP+A S ++G +L +VQL MKKNQTLQ EI GH PR+ D+ +R + L AA
Sbjct: 1496 ERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDL 1555
Query: 1560 GPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKD 1619
L LQ W RL R +RL DA AQQ+Y DA EAEAW+GEQEL+++ E KD
Sbjct: 1556 EERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKD 1615
Query: 1620 ELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGL 1679
E A +K+H ++A+ DY + I QLA+ +Q ++ HPE +I Q QVDK YAGL
Sbjct: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
Query: 1680 KELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREF 1739
K++A ER+ +L+ L QL+RE DDLEQWI E+E+VA+S E+GQD++HVT+LRDKFR+F
Sbjct: 1676 KDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDF 1735
Query: 1740 SRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAA 1799
+R+T IGQERVD+ NA LI GH+ AT+AEWKD LNE WADLLEL+DTR Q+LAA
Sbjct: 1736 ARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAA 1795
Query: 1800 AYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQV 1859
+Y+L R+ + + L + K ++LP+ G D + AE+ R H A+E ++ L QVQQ
Sbjct: 1796 SYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQF 1855
Query: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVREL 1919
QD RLQ AYAG+KAE I Q V+ AW L + A RR L+DT DKFRFF R+L
Sbjct: 1856 QDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDL 1915
Query: 1920 MLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHY 1979
+ WM+ + Q++ QERPRDVSS +L++K QGI AEIE R+ FS+C+++G+ LL R H
Sbjct: 1916 LSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQ 1975
Query: 1980 AAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSA 2039
A+EEI EKL Q+ +RR+E EKW+ + + L+++LEV F RDA +AEAWL +QEP + S
Sbjct: 1976 ASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASG 2035
Query: 2040 ELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPP 2099
+ G TVD VE LIKRHEAF+KS +W ERF ALEK T LE +E++ +R EE Q
Sbjct: 2036 DFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIA-ERPAEETGPQEE 2094
Query: 2100 APEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLE 2159
E P + S +GT P+ + Q P G DG+ S
Sbjct: 2095 EGETAGEAPVSHHAATERTSPGEEEGTWPQ---NLQQPPPPGQHKDGQKS---------- 2141
Query: 2160 HSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQE 2219
+GDE T P + S E ATLP P Q
Sbjct: 2142 -----------TGDERP---------TTEPLFKVLDTPLS-EGDEPATLP--APRDHGQS 2178
Query: 2220 -QMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSL 2278
QMEG L RK ++E KKA+NRSW N+YCVLR L FYKDAK + G+PYHGE P++L
Sbjct: 2179 VQMEGYLGRKHDLEGPNKKASNRSWNNLYCVLRNSELTFYKDAKNLALGMPYHGEEPLAL 2238
Query: 2279 ARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPE 2338
A +A +Y+K+KHVFKL L +G E+LF KDE EM SWL+ V+ AI + S
Sbjct: 2239 RHAICEIAANYKKKKHVFKLRLSNGSEWLFHGKDEEEMLSWLQGVSTAINESQS------ 2292
Query: 2339 EPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK 2390
R +++ +P +S GP K +++EKRFSFF K K
Sbjct: 2293 -------IRVKAQSLPLPSLS-----GPDASLGK----KDKEKRFSFFPKKK 2328
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 2303 bits (5969), Expect = 0.0
Identities = 1154/2139 (53%), Positives = 1535/2139 (71%), Gaps = 22/2139 (1%)
Query: 6 SPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTK 65
S T+F+++ Q YS IN RWD PD + DND+SSARLFERSRIKALADERE VQKKTFTK
Sbjct: 3 SATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTFTK 62
Query: 66 WVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQF 125
WVNSHLARV+CR+ DLY DLRDGR L++LLEVLSGE+LPKPTKG+MRIHCLENVDKALQF
Sbjct: 63 WVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQF 122
Query: 126 LKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLW 185
LKEQ+VHLENMGSHDIVDGNHRL LGL+WTIILRFQIQDI V+T++ +E +SAKDALLLW
Sbjct: 123 LKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLW 182
Query: 186 CQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAE 245
CQMKTAGYP+VNV NFT+SW+DGLAFNA++HKHRPDL+DF+ LK NA +NL++AFN+AE
Sbjct: 183 CQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAE 242
Query: 246 KELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAER 305
++LG+ LLDPEDV + PDEKSIITYV +YHYFSKMK LAVEGKR+GKV+DHA+E E+
Sbjct: 243 RQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEK 302
Query: 306 LVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNL 365
++EKY LAS+LL WIEQTI LN R+ ANSL+GVQ QLQ+F++YRTVEKPPKF EKGNL
Sbjct: 303 MIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNL 362
Query: 366 EVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQ 425
EVLLFTIQS++RANNQKVYTP +G+L+SDIN+AWE LE+AE+ RELALR ELIRQEKLEQ
Sbjct: 363 EVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQ 422
Query: 426 LAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVD 485
LA RFDRKAAMRETWLSENQRLV+QDNFG +LAAVEAA +KHEAIETD AY RV+A++
Sbjct: 423 LARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALE 482
Query: 486 AVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD 545
+A EL E YHD KRI AR+ N+ RLW +L++++ +RR+RL L LQK+FQD+L+ +D
Sbjct: 483 DLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSID 542
Query: 546 WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR 605
WM+E+K L S + G+HL VEDLLQ H+L+EADIA+Q ++V+A++A+ L+F GK Y+
Sbjct: 543 WMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF-TEGKGYQ 601
Query: 606 PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665
PCDPQ++ +R++ LEQ +E L +AA R+A+LE+S+RLW+F WE+ EAE+W++E++ + +
Sbjct: 602 PCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYS 661
Query: 666 SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL 725
S D G+DLT L L KH A E+ G L+ ++ +VA G Q AR E+
Sbjct: 662 SLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEV 721
Query: 726 QAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL 785
AQW++L+ LA + L A + +QFQ DA+D++AWL DA RL+S ++G DE +T+AL
Sbjct: 722 SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRAL 781
Query: 786 ARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERA 845
++H+ EE+ R ++ L +QA P +P+V R+ L Y+++ A+A R
Sbjct: 782 GKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQ 841
Query: 846 RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLA 905
+ L+ AL LYT+ E AC LW+ EKE+WL + +P+ LEDLEVVQ RF+ L+ EM TL
Sbjct: 842 QRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLM 901
Query: 906 AQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHL 965
QI VN A L+++ P + Q+ LN RWQ F+ L ++ A+ SAL + NY +
Sbjct: 902 TQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCV 961
Query: 966 ECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL 1025
+C ET W+ +KTKV+EST+ LG DLAG++A+QRKL+G ERD+ AI ARV L RE+ L
Sbjct: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
Query: 1026 AAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQ 1085
HP Q I R + ++ W+ L+ +++ +E+ LGE +LQ FL+ LDDFQAWL TQ
Sbjct: 1022 MDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ 1081
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AVASE+ P +LPEAE LL QHA ++ E++ Q Y R++ GE+V + Q DP+ L L Q
Sbjct: 1082 KAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQ 1141
Query: 1146 RLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQ 1205
RLE L TGW LGRMWESR LAQ GFQ F +DA+QAE +LS+QEY L+H E P +L+
Sbjct: 1142 RLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLE 1201
Query: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQD 1265
AA+A I+K EDF+ +M+ N +++ +++G +LV+EGN+++DKI+EK IE RH+KN +
Sbjct: 1202 AAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNE 1261
Query: 1266 AAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAE 1325
AQ+ LRDN E Q+FLQ+C EL LWI++K+LT+QDVSYDEARNLH KW KHQAF+AE
Sbjct: 1262 KAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAE 1321
Query: 1326 LAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRA 1385
LA+++ WL+ +D EG++L EKP+ ALVS+KL LHR WDEL+ TT+ K + L A +
Sbjct: 1322 LASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSS 1381
Query: 1386 ELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQ 1445
+L Q+ L W+ +++ QL SDD GKDLTSVN +L K + +E ++ VR++E+ + AQ
Sbjct: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
Query: 1446 AKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVT 1505
++ +E A ++E++F L +P+ R ++L++SR + Q RD+EDE LWV
Sbjct: 1442 VPSMGEEGGDA------DLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
Query: 1506 ERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAA------A 1559
ERLP+A S ++G +L +VQL MKKNQTLQ EI GH PR+ D+ +R + L AA
Sbjct: 1496 ERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDL 1555
Query: 1560 GPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKD 1619
L LQ W RL R +RL DA AQQ+Y DA EAEAW+GEQEL+++ E KD
Sbjct: 1556 EERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKD 1615
Query: 1620 ELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGL 1679
E A +K+H ++A+ DY + I QLA+ +Q ++ HPE +I Q QVDK YAGL
Sbjct: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
Query: 1680 KELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREF 1739
K++A ER+ +L+ L QL+RE DDLEQWI E+E+VA+S E+GQD++HVT+LRDKFR+F
Sbjct: 1676 KDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDF 1735
Query: 1740 SRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAA 1799
+R+T IGQERVD+ NA LI GH+ AT+AEWKD LNE WADLLEL+DTR Q+LAA
Sbjct: 1736 ARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAA 1795
Query: 1800 AYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQV 1859
+Y+L R+ + + L + K ++LP+ G D + AE+ R H A+E ++ L QVQQ
Sbjct: 1796 SYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQF 1855
Query: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVREL 1919
QD RLQ AYAG+KAE I Q V+ AW L + A RR L+DT DKFRFF R+L
Sbjct: 1856 QDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDL 1915
Query: 1920 MLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHY 1979
+ WM+ + Q++ QERPRDVSS +L++K QGI AEIE R+ FS+C+++G+ LL R H
Sbjct: 1916 LSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQ 1975
Query: 1980 AAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSA 2039
A+EEI EKL Q+ +RR+E EKW+ + + L+++LEV F RDA +AEAWL +QEP + S
Sbjct: 1976 ASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASG 2035
Query: 2040 ELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPP 2099
+ G TVD VE LIKRHEAF+KS +W ERF ALEK T LE +E++ +R EE Q
Sbjct: 2036 DFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQ-IAERPAEETGPQEE 2094
Query: 2100 APEPTASVPPGDLVGGQTAS--------DTTWDGTQPRP 2130
E P + S ++W+ QP P
Sbjct: 2095 EGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEP 2133
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 1962 bits (5082), Expect = 0.0
Identities = 1093/2290 (47%), Positives = 1477/2290 (64%), Gaps = 112/2290 (4%)
Query: 7 PTDFDSLEIQGQYSDINN---RWDLPDSDWDND-----SSSARLFERSRIKALADEREAV 58
P + D++E G + NN RW+ PD W+ + +++A LFE SRIKALADEREAV
Sbjct: 5 PGEVDNME--GLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAV 62
Query: 59 QKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLEN 118
QKKTFTKWVNSHLARV C +GDLY DLRDG L RLLEVLSGE LP+PT+GRMRIH LEN
Sbjct: 63 QKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLEN 122
Query: 119 VDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSA 178
VDKALQFLKEQ+VHLEN+GSHDIVDGNHRLTLGLVWTIILRFQIQ I +ETEDN+E +SA
Sbjct: 123 VDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSA 182
Query: 179 KDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQ 238
KDALLLWCQMKTAGYP VN+ NFTTSWRDGLAFNA++H+HRPDL+DF L K NA+YNLQ
Sbjct: 183 KDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQ 242
Query: 239 NAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLD 298
AF AE+ LGL +LLDPEDVN++ PDEKSIITYV ++YHYFSKMKALAVEGKRIGKVLD
Sbjct: 243 RAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLD 302
Query: 299 HAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPK 358
+E +++E+YE LA+ELL WI +T+ +++++ ANSLSGVQ QLQ+F +Y T+EKP K
Sbjct: 303 QVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVK 362
Query: 359 FTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELI 418
F EKGNLEVLLF+IQSKLRA N++++ PREG I DI+KAW LEKAEHERE ALR ELI
Sbjct: 363 FQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELI 422
Query: 419 RQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYS 478
RQEKLE LA RFD K AMRE+WL+ENQRLVSQDNFG EL AVEAA++KHEAIE DI AY
Sbjct: 423 RQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYE 482
Query: 479 GRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQ 538
RVQ V +A LAAE Y+DI+R+AA++ +V R W L +V ARR RL NL LQKVFQ
Sbjct: 483 ERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQ 542
Query: 539 DLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFC 598
+++Y++DWMEEM+ +L S++ G+HL +DLLQ H L+E DIA Q+ERV A++A+ALRF
Sbjct: 543 EMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRF- 601
Query: 599 NPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVR 658
+ + Y+PCDPQ++ RV + L E AA RRA LE SR LW L E+ EAE+W R
Sbjct: 602 SQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWAR 661
Query: 659 EQQHLLASADTG---------------RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQ 703
+++ LL +A G DL+ RLL +H L+GE+ GR L+ L
Sbjct: 662 DKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRC 721
Query: 704 GQQLVAEG---HPGASQA-----SARAAELQAQWERLEALAEERAQRLAQAASLYQFQAD 755
G++LVA G PGA + RAA + +W+RLE A R +RL +A +L+QF AD
Sbjct: 722 GEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGAD 781
Query: 756 ANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPP 815
+ + WL DA RL ++ + GHDE S++ LARQHRAL E+ +HR + LR Q A L
Sbjct: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
Query: 816 TLSRTPEV---QGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKE 872
P V Q RV E+ + E+ A R + L ALA+Y M E AC LW+ EKE
Sbjct: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
Query: 873 QWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNT 932
QWL + +P+ L+D+EVVQ RFE+L+ EMN+L ++ VN ++L++ P D + +
Sbjct: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
Query: 933 QEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLA 992
Q+ LN RW + L + +K +++ L ++N+ LE E +A +REK + +ES G
Sbjct: 962 QDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG--- 1018
Query: 993 GVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRA 1052
ALQ +L+G E L+A+ R L EA LA PAQA ++ E+ W L +
Sbjct: 1019 ---ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALAS 1075
Query: 1053 TMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPA--TLPEAEALLAQHAAL 1110
+ E++ A RLQ FL LD F WL R Q A EGP +L EA+ALLA+HAAL
Sbjct: 1076 AAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAAL 1135
Query: 1111 RGEVERAQSEYSRLRALGEE-VTRDQAD-PQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
+ EV++ + +Y+R+ A E + D A+ L L + L L GW +L +WE+R+ L
Sbjct: 1136 KEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREAL 1195
Query: 1169 AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228
QAH +Q FLRD RQA VL +QE LS E+PGT+++ + A+K+ DF++TM+ + +++
Sbjct: 1196 VQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKM 1255
Query: 1229 HGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCH 1288
++A L+ +GNI+ ++ +E + ++++NQ AQQ++ +L D E QHFL+DCH
Sbjct: 1256 QVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCH 1315
Query: 1289 ELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP 1348
EL WI EKML A+D + ++ LH +W +HQAFMAELA NK+WL+K+++EG++L EKP
Sbjct: 1316 ELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP 1375
Query: 1349 ELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS 1408
EL A V +KL ++ + W ELE+TTQAKAR LF+A++A+ QS L+ L +++QL
Sbjct: 1376 ELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQD 1435
Query: 1409 DDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEE 1468
D G DL +VN LKK Q +E ++ +EV +QAQ AL E V AV E
Sbjct: 1436 VDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGE 1495
Query: 1469 KFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMK 1528
+ L +P++ER R L AS+E HQ D++DE+ WV ERLP+A E G L +VQ +K
Sbjct: 1496 RLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIK 1555
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRG 1581
KNQ L++EIQ H PR+ ++ ER AL A+ PE L +LQ W L E R
Sbjct: 1556 KNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQ 1614
Query: 1582 KRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYA 1641
+ L+ A + +Q+Y D AE EAW+GEQEL MM ++K KDE S +KKH LEQ + +Y
Sbjct: 1615 QVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYE 1674
Query: 1642 QTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRR 1701
++I QL+ + +++ HP+S +IS RQ+QVD+LY LKEL ERR L++ L QL R
Sbjct: 1675 ESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSR 1734
Query: 1702 ELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGL 1761
++ +LE WI E+EVVA S ELGQD+EHV++L++KF EF+ +T G+ER+ + N + + L
Sbjct: 1735 QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL 1794
Query: 1762 IAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQ 1821
I GH A AT+AEWKD LNEAWA+LLEL+ TR Q+LAA+ EL +F AR+ +++ K+
Sbjct: 1795 IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKR 1854
Query: 1822 QQLPDGT--GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879
++LP T +A ++QR A+EHD+Q L QV+Q+Q+ +L+ YAG+ AE I
Sbjct: 1855 RRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 1914
Query: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDV 1939
Q V + W +L + R + T D RF VR+L+ WMD + Q+ A ++PRDV
Sbjct: 1915 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDV 1974
Query: 1940 SSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETA 1999
SS ++++ QG+K E+EAR ++C ++G+ LL A+EI +L +L R++E +
Sbjct: 1975 SSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVS 2034
Query: 2000 EKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQ 2059
EKW +WLQ +LEV F ++A +A+AWL +QEPL++S ELG +VDEVE LI+RHEAF+
Sbjct: 2035 EKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFR 2094
Query: 2060 KSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAP--------EPT---ASVP 2108
K+A AWEERF +L +LT +E + + E+ KQPP P +PT A
Sbjct: 2095 KAAAAWEERFSSLRRLTTIE---------KIKAEQSKQPPTPLLGRKFFGDPTELAAKAA 2145
Query: 2109 PGDLVGG---------QTASDTTWDGTQPRP-------PPSTQAPSVNGVCTDGEPSQPL 2152
P GG + ASDT + R P P + D P P
Sbjct: 2146 PLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRI-----DRLPEIP- 2199
Query: 2153 LGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRG 2212
R+E ++ P P D A P T A P+ ESA A PR
Sbjct: 2200 ---GRVEPAALPAAP----EDAAETP------ATPAAAEQVRPRPERQESADRAEELPRR 2246
Query: 2213 PEPSAQEQME 2222
P QE ++
Sbjct: 2247 RRPERQESVD 2256
Score = 361 bits (926), Expect = 5e-99
Identities = 487/2091 (23%), Positives = 833/2091 (39%), Gaps = 208/2091 (9%)
Query: 409 RELALRTELI--RQEKLEQLAA--RFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAV 464
R+ AL T L+ R+ +LEQ A + ++ W+ E Q + G L + +
Sbjct: 515 RQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLL 574
Query: 465 RKHEAIETDIVAYSGRVQAVDAVA---AELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
+KH +E DI A S RV+A++A A ++L + D + I R ++V L++ A
Sbjct: 575 QKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAA 634
Query: 522 ARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLG---------------RHLAGV 566
RR L + L + Q+L W + + L++ G L+
Sbjct: 635 RRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
Query: 567 EDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL----VSERVAKLEQS 622
LL H++++ ++ + ++ G P + ++ER A +
Sbjct: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
Query: 623 YEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNK 682
++ L E AA R RL+E+R L +F ++ W+R+ L A+ D G D + RL +
Sbjct: 755 WQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQ 814
Query: 683 HTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEE---- 738
H AL GE+ GP+ +QL G GAS A LQ + E L E
Sbjct: 815 HRALTGEVEAHRGPVS---GLRRQLATLG--GASGAGPLVVALQVRVVEAEQLFAEVTEV 869
Query: 739 ---RAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
R Q L A ++Y+ + + E W+ + + + S + + + + +L++E
Sbjct: 870 AALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQE 929
Query: 796 IRSHRP-TLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALAL 854
+ S LD + + EV+ L + + +R + A L +
Sbjct: 930 MNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLV 989
Query: 855 YTMLSEAGACGLWVEEKEQWLN-----GLALPERLEDLEVVQQRFETLEPEMNTLAAQIT 909
+ E V EK + + G AL RL LE Q LEP L +
Sbjct: 990 ENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQ---ALEPRQAALLEE-- 1044
Query: 910 AVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTE 969
A L + P R+ E+L W A A+ +A +Q + +
Sbjct: 1045 -----AALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
Query: 970 TQAWMREKTKVIESTQG-LGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
W+ + ++G L N L AL + A + +++ + + AL A
Sbjct: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAA 1159
Query: 1029 HPAQ---AVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQ 1085
A+ +A++ L ++ GW L R E+L +A Q FLR L L +
Sbjct: 1160 DGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQE 1219
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
A++ E P T+ E L QH +E +Q + E + R ++ Q
Sbjct: 1220 MALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGN----IYGEQ 1275
Query: 1146 RLEALGTGWEELGRMWESRQGRLAQAHG---FQGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
EA+ E+ Q + + H Q FLRD + +G + + + G
Sbjct: 1276 AQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARD----G 1331
Query: 1203 TLQAADAAIKKL---EDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERR 1259
T + K+ + FM+ + N E + + G+QL+ E A +R+K I +
Sbjct: 1332 TREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQC 1391
Query: 1260 HKKNQDAAQQFLGRLRDNREQQHFLQDCHEL--KLWIDEKMLTAQDVSYDEARNLHTKWQ 1317
+ + Q +L + + +Q EL KL E L D D A ++++ +
Sbjct: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLA-TVNSQLK 1450
Query: 1318 KHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKAR 1377
K Q+ +++ + ++ + L LE P K LV E+ + R L Q + R
Sbjct: 1451 KLQSMESQVEEWYREVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRR 1509
Query: 1378 SLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
L + A +W++ + G L +V +KK Q L E+
Sbjct: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 1569
Query: 1438 EVEAIQAQAKALAQ-EDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRD 1496
+E + +A ALA A V R ++ + L + R + L A+ + Q++ D
Sbjct: 1570 RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 1629
Query: 1497 VEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGA 1556
V + W+ E+ + S + GKD S L+KK+ L++ ++ +E IA L + RAL
Sbjct: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 1689
Query: 1557 AAA--GPELAELQEMWKRLGHELELRGKRLEDALRAQ----QFYRDAAEAEAWMGEQELH 1610
+++ Q RL L+ G+ AL Q Q R +E E W+ E+E+
Sbjct: 1690 MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
Query: 1611 MMGQEKAKDELSAQAEVKKHQVLEQALADYAQTI-----HQLAASSQ---DMIDHEHPES 1662
E +D + VL++ +++A +LAA +Q ++I+ H +
Sbjct: 1750 AGSPELGQD-------FEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
Query: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQE-REVVAASHE 1721
++ + +++ +A L EL G R + L L + + +L+ I+E R +
Sbjct: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 1862
Query: 1722 LGQDYEHVTMLRDKFREFSRDTSTIGQE--RVDSANALANGLIAGGHAARATVAEWKDSL 1779
+ + ++ R F D + + ++ A + AG HA +A + +
Sbjct: 1863 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAE--AIASREQEV 1920
Query: 1780 NEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTG-RDLNAAEAL 1838
+ W +LL + +++ + RF R L+ + Q+ RD+++ E L
Sbjct: 1921 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL 1980
Query: 1839 QRRHCAYEHDIQALSPQVQQVQDDGHRL-------------QKAYAGDKAEEIG----RH 1881
H + +++A P++ Q+ G L Q G + EE+ RH
Sbjct: 1981 MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
Query: 1882 MQ---------------AVAEAWAQLQ---------GSSAARRQLLLDTTDKFRF----- 1912
+ VA+AW Q GSS + L+ + FR
Sbjct: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100
Query: 1913 ---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRF--SSCI 1967
F ++R L ++++ + Q L+ + G E+ A+A
Sbjct: 2101 EERFSSLRRLTT-IEKIKAEQSKQP------PTPLLGRKFFGDPTELAAKAAPLLRPGGY 2153
Query: 1968 DMGKELLAR--SHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLV------LEVLVFG 2019
+ G E LAR S + E+ ++ + R++ E+ Q ++D L + +
Sbjct: 2154 ERGLEPLARRASDTLSAEVRTRVGYV--RQELKPERLQPRIDRLPEIPGRVEPAALPAAP 2211
Query: 2020 RDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALE 2079
DA A + E + E + D E L +R ++ +V E + E
Sbjct: 2212 EDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQE 2271
Query: 2080 EREKER------------KRKREEEERRKQPPAPEPTASVPPGDLVGGQ-TASDTTWDGT 2126
E E +R+RE ERR + GDLV G+ T +D
Sbjct: 2272 SAEHEAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQ 2331
Query: 2127 QPRPPPSTQAPSVNGVCTDGEPSQPLLGQQR-LEHSSFPEG-------PGPGSGDEANGP 2178
+ P G P+ P L Q R L P G P P + P
Sbjct: 2332 EKEAGP-------------GLPAGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARDRP 2378
Query: 2179 RGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEMEAFGKKA 2238
+ R+ R R + + A + P P P+ Q EG L RK+E++A +K+
Sbjct: 2379 KPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDA-NRKS 2437
Query: 2239 ANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKL 2298
+NRSW ++YCVL +G LGFYKD+K ++G + GE +SL +A VA DY+K+KHVFKL
Sbjct: 2438 SNRSWVSLYCVLSKGELGFYKDSKGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVFKL 2497
Query: 2299 GLQDGKEYLFQAKDEAEMSSWLRVVNAAIAT-ASSASGEPEEPVVPSTTRG 2348
QDG E+L QAKDE EM+ WL V +++A A A P ST G
Sbjct: 2498 QTQDGSEFLLQAKDEEEMNGWLEAVASSVAEHAEIARWGQTLPTTSSTDEG 2548
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 936 bits (2418), Expect = 0.0
Identities = 641/2107 (30%), Positives = 1030/2107 (48%), Gaps = 85/2107 (4%)
Query: 43 FERSRIKALADEREAVQKKTFTKWVNS--HLARVTCRVGDLYSDLRDGRNLLRLLEVLSG 100
+E I+ L +Q+KTFTKW+N+ + ++ +LY++L DG +LLRLLE++SG
Sbjct: 5 YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
Query: 101 EILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRF 160
E LP P++GR+R+H LEN +AL FL+ KV + +G +IVDG+ L LGL+W IILRF
Sbjct: 65 EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
Query: 161 QIQDISVETED---NKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHK 217
QI IS++ E+ + S K+ALL+WCQ KTA Y NVN+ +F+ SW DGL FNA++H
Sbjct: 124 QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
Query: 218 HRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYY 277
HRPDLLD+ SL+ +NL AF +AE+ELG+ +LLDPEDV QPDE+SI+TYV+ YY
Sbjct: 184 HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
Query: 278 HYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSL 337
HY S++ +R+ K+L E E L +YE L ++LL+WI + + L R +SL
Sbjct: 244 HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
Query: 338 SGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINK 397
++ L +F +RT EKPP+ ++G E LLF +Q+ L+A N++ + P EG ++++++
Sbjct: 304 PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
Query: 398 AWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNF-GLE 456
W LE AE R AL+ L++ ++LE LA RF KAA+RE++L + ++++ Q
Sbjct: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
Query: 457 LAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL 516
LA VEAAV++ +E I+ GR QA+ +A L E+YH +A RQ V W L
Sbjct: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
Query: 517 RQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELV 576
Q + +R+++ + + Q++ +EE++ +S G+ LA V +LLQ H+L+
Sbjct: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
Query: 577 EADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
EA ++ V ++ +++ + L Q ++L L ARRA
Sbjct: 544 EAQVSAHGAHVSHLAQQTAEL----DSSLGTSVEVLQAKARTLAQLQQSLVALVRARRAL 599
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGP 696
LE++ + FL E EAW++E + +A GRDL+ L KH AL E+
Sbjct: 600 LEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAV 659
Query: 697 LKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADA 756
+ +G+ L A P RA +Q W+ L+ R RL A + Q+ ADA
Sbjct: 660 CVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADA 719
Query: 757 NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQ------- 809
+ +WL + + G D+ + + L R+H LE +R+ L L EQ
Sbjct: 720 AEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASAR 779
Query: 810 -------AAALPP-------------------------TLSRTPEVQGRVPT-------L 830
+A PP L P+ T L
Sbjct: 780 ASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHL 839
Query: 831 ERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVV 890
+ YE L+A A R LE A+AL+ S G LW+E++ L + + + LEV+
Sbjct: 840 SQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQ--RVQPQADTLEVM 897
Query: 891 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950
Q ++E + V+ AEQL + P +I QE+L+ RW Q L K
Sbjct: 898 QLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREK 957
Query: 951 KAALTSALSIQNYHLECTETQAWMREKTKVIESTQ-GLGNDLAGVLAL-QRKLAGTERDL 1008
L ++ + ++ EC TQ +R+ +E+ Q G D L L Q+K ER +
Sbjct: 958 AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRV 1017
Query: 1009 EAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ 1068
+ + V ++ A + Q + L++VQ + R R ++ +AR Q
Sbjct: 1018 HFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQE-----QVAQRARRQAETQAR--Q 1070
Query: 1069 DFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128
FL+ W Q + S+E + A+ LL +H L E+ Q +L A
Sbjct: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQS 1130
Query: 1129 EEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL 1188
+ + P + L LG +EL +WE RQ L + Q F R+
Sbjct: 1131 QPMAALDC-PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATC 1189
Query: 1189 SSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK 1248
++ + L + ++ A + +++ +F + G R L G +LV + A
Sbjct: 1190 ANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHT 1249
Query: 1249 IREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDE 1308
+RE+ SI+ + + Q ++Q +L + + Q + QD EL W++EK L A
Sbjct: 1250 VREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGA 1309
Query: 1309 ARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDEL 1368
RN+ ++H+A +EL A + ++ + + GREL +P + + +L+ L +W+ L
Sbjct: 1310 RRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
Query: 1369 ETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML 1428
+ L A + E + + LE L+ L S + G+DL S L K+ Q L
Sbjct: 1370 NRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQL 1429
Query: 1429 EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASR 1488
E E ++ A+ + A +A E ++ R +E L + R +LQAS
Sbjct: 1430 ESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLE----LLQGHLAIRGLQLQASV 1485
Query: 1489 EQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR 1548
E HQF E+ WV E +P S + + L Q L +K++ LQ E++ H+ ++ +
Sbjct: 1486 ELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL 1545
Query: 1549 ERQRALGAAAAGP-------ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
R+L AA+ P + EL+ W L E R + L+ A+ QQ++ D +E E
Sbjct: 1546 SSGRSL-AASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELE 1604
Query: 1602 AWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPE 1661
W+ E+ + ++ +DE + + KHQ L++ LA Y ++ +L ++Q + E PE
Sbjct: 1605 GWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPE 1664
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI-QEREVVAASH 1720
R+ Q ++ + L+ELA R L+ LRL + RE +DL+ W+ +++
Sbjct: 1665 QQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGE 1722
Query: 1721 ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLN 1780
LG+D EH L KF +F +G +RV + LA L+ GH+A V + + L
Sbjct: 1723 SLGEDPEHALHLCTKFAKFQHQVE-MGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQ 1781
Query: 1781 EAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQR 1840
AW++L EL RG L R + L +VQ K LP+ RDL EA R
Sbjct: 1782 TAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLR 1841
Query: 1841 RHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARR 1900
H E ++ Q+Q++ + R+QK G +A + + QAV +AWA LQ RR
Sbjct: 1842 SHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRR 1901
Query: 1901 QLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARA 1960
L RF AVR+ W V + +E ++ SS L + Q ++AE+EAR
Sbjct: 1902 AQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE 1961
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGR 2020
+ +G++ L + +E+ E+L LQ +R + + W K + LQ + +F R
Sbjct: 1962 KLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLR 2021
Query: 2021 DAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEE 2080
+ G E L +QE ++++ LG +V+EVE LI++HE F K A +++ AL +
Sbjct: 2022 ECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR 2081
Query: 2081 REKERKR 2087
R + R R
Sbjct: 2082 RPRVRDR 2088
Score = 499 bits (1284), Expect = e-140
Identities = 425/1715 (24%), Positives = 754/1715 (43%), Gaps = 70/1715 (4%)
Query: 394 DINKAWERLEKAEHERELALR----TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVS 449
D+ AW L + R ALR T + ++ LE L ++ ++
Sbjct: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
Query: 450 QDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELA----AERYHDIKRIAAR 505
+N +L +EA +R H+ +E ++V ++Q + A + + H +++ R
Sbjct: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQ---R 1882
Query: 506 QHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAG 565
Q V + W L++ + RR +L L + + W ++ LQ ++ + +
Sbjct: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
Query: 566 VEDLLQLHELVEADIAVQA----ERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQ 621
L H+ + A++ + + + + L P KE V E + L+
Sbjct: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKE--------VQEELRALQD 1994
Query: 622 SYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLN 681
+ + + A ++ RL+ ++ FL E G E + Q+ L ++ G + +L+
Sbjct: 1995 QRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIR 2054
Query: 682 KHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAE----LQAQWERLEALAE 737
KH LK+ Q ++ A + R + L + R++ LAE
Sbjct: 2055 KHEVF----------LKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAE 2104
Query: 738 ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIR 797
R L + + F A E W+ + + P D +H+A E E++
Sbjct: 2105 SRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQ 2164
Query: 798 SHRPTLDALREQAAAL-PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYT 856
+H + ++ ++ AL + R EV R+ L +H+E+L+ R + LE
Sbjct: 2165 AHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLE 2224
Query: 857 MLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEM--NTLA-AQITAVND 913
L W++EKE +N L + LE +++R +T+ A I +++D
Sbjct: 2225 FLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISD 2284
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++ QL +P I + QLN+RW F + L AL I E
Sbjct: 2285 LSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKR 2344
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQA 1033
++EK +I++ G DL V L RK ER++ I A+V L RE L P A
Sbjct: 2345 IQEKEALIQALD-CGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAA 2403
Query: 1034 VAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEG 1093
+ R +EV W LR+ ++R E+L + Q L + R + + +
Sbjct: 2404 HGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPA 2463
Query: 1094 PATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTG 1153
P + EA +L +H + E++ S R+ G+++ P +RQ L L
Sbjct: 2464 PRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLT-AGHPFSSDIRQVLAGLEQE 2522
Query: 1154 WEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKK 1213
L W+ Q +L QA Q FL + E L S+E L+ + L + + K
Sbjct: 2523 LSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWK 2582
Query: 1214 LEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGR 1273
+ ++ +I L R L G+ A + ++ R + A R
Sbjct: 2583 HKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHR 2642
Query: 1274 LRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWL 1333
L + R+ Q FLQD E+ W+ EK L A + + L + QK Q F AEL A+
Sbjct: 2643 LEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ 2702
Query: 1334 DKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCC 1393
++ +EG+ L + E+L +L W EL+ +Q K L A A +S
Sbjct: 2703 QELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSME 2762
Query: 1394 ALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED 1453
LE+WLE ++ +L + G+ L V LL Q+ LE + + ++ EA+ QA+A +E
Sbjct: 2763 ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREG 2822
Query: 1454 QG-AGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMAS 1512
A +VE +R + ++F++L +P++ER L+A +F RD ++E+ WV E+LP+A+
Sbjct: 2823 HCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAA 2882
Query: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPR---IADLRERQRALGAAAAGPELAELQEM 1569
+ ++G+ L +V+ L +++Q L+ E+ HE + + G AA A +Q++
Sbjct: 2883 AQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQL 2942
Query: 1570 WKRLGH---ELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAE 1626
K + H E R L+ A AQQF + EA +W+ E+ + ++ + QA
Sbjct: 2943 EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQAL 3002
Query: 1627 VKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGER 1686
+++ + ++ L ++ I +L ++ + ++PES ++ + V + +A L A R
Sbjct: 3003 LRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEAR 3062
Query: 1687 RERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTI 1746
LQE L+L QL RE L+ W+ + A S + GQD E V +L +KF F ++ ++
Sbjct: 3063 GHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSL 3122
Query: 1747 GQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRF 1806
GQ +V + LA L G + + + AW L + + R + LAAA+E+ F
Sbjct: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSF 3182
Query: 1807 LHGARQALARVQHKQQQLP-DGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHR 1865
A + R+Q K + + G L++ LQ++H E +++A+ +V ++Q + R
Sbjct: 3183 QQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACR 3242
Query: 1866 LQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
L + + + V EAWA LQ + R Q L F +EL+ W E
Sbjct: 3243 LGQLHPAAPG-----GLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQE 3297
Query: 1926 VNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEIS 1985
++E DV+ A+ ++ + + EI + G++L+ SH+ + E++
Sbjct: 3298 RQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVT 3357
Query: 1986 EKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTV 2045
E L +L+ R QE E W + + + AEAWL E L+ + G +V
Sbjct: 3358 ECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSV 3417
Query: 2046 DEVESLIKRHEAFQKSAVAWEERFCALEKLTALEE 2080
+VE L+ RH+ +K A EE+F ++K T +E+
Sbjct: 3418 SDVELLLHRHQDLEKLLAAQEEKFAQMQK-TEMEQ 3451
Score = 431 bits (1109), Expect = e-120
Identities = 408/1783 (22%), Positives = 762/1783 (42%), Gaps = 89/1783 (4%)
Query: 361 EKGNLEVLLFTIQSKLRANNQKV--------YTPREGRLISDINKAWERLEKAEHERELA 412
E G L L LRA+ +K+ +T RE + I W RL+ +R
Sbjct: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQ--LQSIQAQWTRLQGRSEQRRRQ 1274
Query: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472
L L QE + +A W+ E + + + G ++ +++HEA E+
Sbjct: 1275 LLASLQLQEWKQDVAELMQ--------WMEEKGLMAAHEPSGARRNILQT-LKRHEAAES 1325
Query: 473 DIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLE 532
+++A V+A+ V EL + R + I R + W+ L + + R + L +
Sbjct: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
Query: 533 LQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSA 592
+++ + L + +E+++G LQS + G+ L + L + H+ +E++ A ++ A+++
Sbjct: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445
Query: 593 SALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGE 652
A G P + E K + E L A R +L+ S L +F
Sbjct: 1446 MA-----HGMAASPA----ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNM 1496
Query: 653 AEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGH 712
+WV E + L GA L KH L+ E+ G ++ L G+ L A GH
Sbjct: 1497 ELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGH 1556
Query: 713 PGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSS 772
P A + EL+ W LE E RAQ L QA + Q+ D +++E W+ + LVSS
Sbjct: 1557 PQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSS 1616
Query: 773 PELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRV-PTLE 831
+ G DE +T L +H+AL+EE+ + +++ L + A L T PE Q V L
Sbjct: 1617 RDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTL--TGPEVPEQQRVVQERLR 1674
Query: 832 RHYEELQARAGERARALEAALALYTMLSEAGACGLWV-EEKEQWLNGLALPERLEDLEVV 890
LQ A R R LE L L+ L EA W+ +K+ G +L E E +
Sbjct: 1675 EQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHL 1734
Query: 891 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950
+F + ++ + ++ A +AE LL+ + Q+ L W + L +
Sbjct: 1735 CTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQAR 1794
Query: 951 KAALTSALSIQNYHLECTETQAWMREK-----TKVIESTQGLGNDLAGVLALQRKLAGTE 1005
AL + H + E ++EK V GL L L+R+L GTE
Sbjct: 1795 GHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTE 1854
Query: 1006 RDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR 1065
R L+ + G + + L G QA A+ R + V W L+ M +R L AR
Sbjct: 1855 RQLQELLETAGRVQK----LCPG--PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERAR 1908
Query: 1066 RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR 1125
L F ++ D+ +W R + + EE L+ H LR E+E + + +
Sbjct: 1909 LLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQAT 1968
Query: 1126 ALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAE 1185
LG++ P +++ L AL +++ + W +Q RL Q FLR+ + E
Sbjct: 1969 QLGQQALLAAGTP-TKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLE 2027
Query: 1186 GVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIH 1245
+L++QE L + + +++ + I+K E F+ + A ++ L E + L
Sbjct: 2028 EILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL------R 2081
Query: 1246 ADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDE-KMLTAQDV 1304
++R++ + +R + ++ A+ L + F Q + + WI + V
Sbjct: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141
Query: 1305 SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRR 1364
+ R+ KHQAF AE+ A+++ + V K+G L + VS++L+ L +
Sbjct: 2142 PPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKH 2201
Query: 1365 WDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKK 1424
W++L + + L D F Q E+W++ + +++ D G+DL L ++
Sbjct: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRR 2261
Query: 1425 QQMLEWEMA---VREKEVEAIQAQAKALAQEDQGAGEV--ERTSRAVEEKFRALCQPMRE 1479
+ A V + + +I + L D ++ +R S+ + ++ + +
Sbjct: 2262 LREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQ-LNNRWASFHGNLLR 2320
Query: 1480 RCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQG 1539
++L+ + E H R++++ + E+ + +++ GKDL SVQ L++K++ L++E+
Sbjct: 2321 YQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREV-- 2378
Query: 1540 HEPRIADLRERQRALG-AAAAGPELA--------ELQEMWKRLGHELELRGKRLEDALRA 1590
P A + +R +G PE A E+ E W +L + R + L+ +A
Sbjct: 2379 -HPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQA 2437
Query: 1591 QQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAAS 1650
Q+ E M + + A+ +++HQ + L + +I ++
Sbjct: 2438 QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARST 2497
Query: 1651 SQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
Q ++ HP S+ I A +++ + L+ E + +LQ+ L L ++ +E+W+
Sbjct: 2498 GQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWL 2557
Query: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGH-AAR 1769
+E AS L + L K + D + ++ + A A GL GGH A+
Sbjct: 2558 CSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLE-VQAGKISALEATARGLHQGGHPEAQ 2616
Query: 1770 ATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTG 1829
+ + + L A L TR L +LQ FL +++ A ++ K +
Sbjct: 2617 SALGRCQAMLLRKEA-LFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGL 2675
Query: 1830 RDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAW 1889
D A ++ ++ ++ A Q Q++Q +G RL + +E I ++ + W
Sbjct: 2676 LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALW 2734
Query: 1890 AQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQ 1949
+LQ +S + L + R +++ EL W++ + +++ A + + ++ Q
Sbjct: 2735 GELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQ 2794
Query: 1950 QGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
+ ++A ++ +A + + + + + H A+++ E+ +L R + E QE+ L
Sbjct: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTAL 2854
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE-- 2067
+ +L F RDA AW+ + PL + + G ++ V L ++H+ + + E
Sbjct: 2855 EARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALT 2914
Query: 2068 --------------RFCALEKLTALEEREKERKRKREEEERRK 2096
F A E +++ EK R E RR+
Sbjct: 2915 RVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRR 2957
Score = 335 bits (858), Expect = 4e-91
Identities = 397/1733 (22%), Positives = 699/1733 (40%), Gaps = 154/1733 (8%)
Query: 419 RQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVA 476
R+ LEQ R F R E WL E + V G +L+ + A++KH+A+E ++
Sbjct: 596 RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV-- 653
Query: 477 YSGRVQAVDAV--AAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534
+ + VD V +L+A R R V W L+ V R RL L +
Sbjct: 654 HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVL 713
Query: 535 KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVE-------ADIAVQAERV 587
+ F D W+ E + L+ G+ A E LL+ H +E A++ E+
Sbjct: 714 QYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQG 773
Query: 588 RAVSASALRF-----------------------CNPG-----KEYRPC------DPQLVS 613
RA SA A F C+PG K P DP +
Sbjct: 774 RAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTIL 833
Query: 614 ERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDL 673
+ L Q YE+L LA RRARLEE+ L+ F GE + W+ +Q LL D
Sbjct: 834 QTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADT 893
Query: 674 TGALRLL--NKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG-ASQASARAAELQAQWE 730
++L N TAL G + + EQ + + +PG ++Q + EL +W
Sbjct: 894 LEVMQLKYENFLTAL-AVGKGLWAEVSSSAEQ----LRQRYPGNSTQIQRQQEELSQRWG 948
Query: 731 RLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL-ARQH 789
+LEAL E+A +LA + + F + + L D L + + + G E + AL Q
Sbjct: 949 QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQK 1008
Query: 790 RALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALE 849
+ L E R H ++ + P + + +QG+V TL+ +++Q + +RAR
Sbjct: 1009 KTLVLERRVHFLQSVVVKVE----EPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
Query: 850 AALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQIT 909
A + L E+ LW E + L + + + + + + L E++ ++
Sbjct: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
Query: 910 AVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLE--- 966
++ ++ + + P + NT L + Q+ + L + ++ L L +Q + E
Sbjct: 1125 QLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDG 1184
Query: 967 ----CTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREA 1022
C QAW+ LG D+ L+L ++ R L + R L
Sbjct: 1185 FTATCANHQAWLH--------LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHG 1236
Query: 1023 NALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLG 1082
L A + +L+ +Q W L+ +R L + +LQ++ + + + W+
Sbjct: 1237 EKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWM- 1295
Query: 1083 RTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF 1142
+ +A+ E L +H A E+ + L+ +G E+ + Q
Sbjct: 1296 EEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQ-ED 1354
Query: 1143 LRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
++ RL+ L + WE L R R L QA + LR + A+ L E L +E
Sbjct: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQ 1414
Query: 1203 TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKK 1262
L+++ K+ + S ++ L ++ G + I E+ ++H +
Sbjct: 1415 DLRSSQRLQKRHQQLESESRTLAAKMAALAS-----MAHGMAASPAILEET----QKHLR 1465
Query: 1263 NQDAAQQFLG----RLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDE----ARNLHT 1314
+ Q L +L+ + E F + W+ E M SY E A++LH
Sbjct: 1466 RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH- 1524
Query: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQA 1374
+KH+ E+ A++ + +V GR L + E+ ++L W ELE +A
Sbjct: 1525 --RKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEA 1582
Query: 1375 KARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAV 1434
+A+ L A + + LE W+E + + S DYG+D + L+ K Q L+ E+A+
Sbjct: 1583 RAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAI 1642
Query: 1435 REKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE----RCRRLQASREQ 1490
+E + A+ L EV R V+E+ R + ++E R R L+ +
Sbjct: 1643 YWSSMEELDQTAQTLT-----GPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRL 1697
Query: 1491 HQFHRDVEDEILWVTERLPMASSMEH-GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRE 1549
H+F R+ ED W+ + A E G+D L K Q +++ R+A R
Sbjct: 1698 HEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRL 1757
Query: 1550 RQRAL--GAAAAGPEL----AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAW 1603
+L +AGP + +LQ W L + RG L D + +RD E
Sbjct: 1758 LAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
Query: 1604 MGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQL---AASSQDMIDHEHP 1660
+ +++ + A+D +A+++ HQ LE+ L + + +L A Q + P
Sbjct: 1818 V-QEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLC--PGP 1874
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI----QEREVV 1716
++ + RQ V + +A L+ +RR +L+ L + R + D W Q+ +V
Sbjct: 1875 QAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVE 1934
Query: 1717 AASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALA-NGLIAGGHAAR------ 1769
+S E L+ ++ R ++ A L L+A G +
Sbjct: 1935 ESSQEPSSG-----PLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEEL 1989
Query: 1770 ATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYELQRFLHGARQALARVQHKQQQLPD 1826
+ + +D + + WA E L Q L L+ L A V K L
Sbjct: 1990 RALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEIL-----AAQEVSLKTSAL-- 2042
Query: 1827 GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVA 1886
G + E L R+H + + A + +++ L++ D+ + + V
Sbjct: 2043 --GSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100
Query: 1887 EAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVI 1946
E A+ +G A LL+ + F +A + W+ Q+ P D+ +
Sbjct: 2101 EL-AESRG-HALHASLLMAS-----FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL 2153
Query: 1947 KNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKM 2006
Q +AE++A + +S G+ LLA+SH A E+S++L L+ ++ + +
Sbjct: 2154 LKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRG 2213
Query: 2007 DWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQ 2059
L+ L F + +AEAW+ +E + +LG ++ L +R F+
Sbjct: 2214 QELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFR 2266
Score = 295 bits (756), Expect = 3e-79
Identities = 402/1834 (21%), Positives = 756/1834 (41%), Gaps = 137/1834 (7%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQ-NQLQSFNSYRTVEKPPKFTEKG-- 363
+++++ +EL+QW+E+ A+ SG + N LQ+ + E T +
Sbjct: 1281 LQEWKQDVAELMQWMEE-----KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVE 1335
Query: 364 NLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKL 423
L+ + + S+ + + T +G + WE L + ER L+ +++ L
Sbjct: 1336 ALQQVGRELLSRRPCGQEDIQTRLQG-----LRSKWEALNRKMTERGDELQQAGQQEQLL 1390
Query: 424 EQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQA 483
QL ++ L + + + G +L + + ++H+ +E++ + ++ A
Sbjct: 1391 RQLQDAKEQ--------LEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAA 1442
Query: 484 VDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL 543
+ ++A +AA + Q ++ RL + L+ +A R +L ++EL +
Sbjct: 1443 LASMAHGMAASP----AILEETQKHLRRL-ELLQGHLAIRGLQLQASVELHQFCHLSNME 1497
Query: 544 MDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKE 603
+ W+ E L G + L + H+ ++ ++ +V+ V +S G
Sbjct: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHP 1557
Query: 604 YRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHL 663
Q + E+ +LE + L AR L+++ ++ +V E E WV E++ L
Sbjct: 1558 ----QAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPL 1613
Query: 664 LASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAA 723
++S D GRD LRL+NKH AL+ E++ ++ + Q L P Q
Sbjct: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVP--EQQRVVQE 1671
Query: 724 ELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE-LGHDEFST 782
L+ Q L+ LA R + L L++F +A D++ WL + E LG D
Sbjct: 1672 RLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHA 1731
Query: 783 QALARQHRALEEEIRSHRPTLDALREQAAALPPT-LSRTPEVQGRVPTLERHYEEL---- 837
L + + ++ + A R A +L S P V+ R L+ + EL
Sbjct: 1732 LHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT 1791
Query: 838 QARAGERARALEAALALYTMLSEAGACGLWVEEKEQWL-NGLALPERLEDLEVVQQRFET 896
QAR G R E L ++ L E V+EK L N +A L LE + +
Sbjct: 1792 QAR-GHALRDTETTLRVHRDLLEVLT---QVQEKATSLPNNVA--RDLCGLEAQLRSHQG 1845
Query: 897 LEPEMNTLAAQITAVNDIAEQLLKANP-PGKDRIVNTQEQLNHRWQQFRRLADGKKAALT 955
LE E+ Q+ + + A ++ K P P + Q+ + W +R + ++A L
Sbjct: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905
Query: 956 SALSIQNYHLECTETQAW---MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIA 1012
A + + + +W +R+ +V ES+Q + + A Q A E E +
Sbjct: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAR-EKLW 1964
Query: 1013 ARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLR 1072
+ +L ++A LAAG P + V LR +Q + + T R++E L ++ Q FLR
Sbjct: 1965 QQATQLGQQA-LLAAGTPTKEV--QEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLR 2021
Query: 1073 SLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAA----LRGEVERAQSEYSRLRALG 1128
+ L + ++ + +++ E E L+ +H L + ++ + RL+ L
Sbjct: 2022 ECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR 2081
Query: 1129 EEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL 1188
RD+ P L R R++ L ESR L + F + A QAE +
Sbjct: 2082 RPRVRDRL-PILLQRRMRVKELA----------ESRGHALHASLLMASFTQAATQAEDWI 2130
Query: 1189 SSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK 1248
+ L PG L+ + K + F + + A+ E + + + G L+++ + A +
Sbjct: 2131 QAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE 2190
Query: 1249 IREKADSIERRHKKNQDAAQQFLGR-LRDNREQQHFLQDCHELKLWIDEK--MLTAQDVS 1305
+ ++ + R+H ++ A G+ L D R FLQ + WI EK + D+
Sbjct: 2191 VSQRLQGL-RKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLG 2249
Query: 1306 YD--EARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHR 1363
D L + ++ + A + + +L PE ++ ++ L+
Sbjct: 2250 QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNN 2309
Query: 1364 RWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLK 1423
RW + L A + ++ + ++ +A + + D GKDL SV LL+
Sbjct: 2310 RWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLR 2369
Query: 1424 KQQMLEWEMAVREKEVEAIQAQAKALAQED-QGAGEVERTSRAVEEKFRALCQPMRERCR 1482
K + LE E+ + +VE+++ + L Q + A + + V E + L ++R
Sbjct: 2370 KHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
Query: 1483 RLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLP-SVQLLMKKNQTLQKEIQGHE 1541
L A + + ++ E+L +RL P + +++++Q + E+
Sbjct: 2430 ALDALHQAQKLQAMLQ-ELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWT 2488
Query: 1542 PRIADLRERQRALGAAAAGPELAELQEMWKRLGHELE-LRGK------RLEDALRAQQFY 1594
I+ R + L A P ++++++ L EL L G +L+ AL Q F
Sbjct: 2489 DSISLARSTGQQL-LTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFL 2547
Query: 1595 RDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK-KHQVLEQALADYAQTIHQLAASSQD 1653
+ E W+ +E + E D L+ + KH++LE L A I L A+++
Sbjct: 2548 SSVEKMERWLCSKE-DSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARG 2606
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
+ HPE+ R + L AG RR RL+E +L ++ ++ W++E+
Sbjct: 2607 LHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK 2666
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+VA L D + K + F + ++ + L+ GGH A +
Sbjct: 2667 NLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQRE-GQRLLQGGHPASEAIQ 2724
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQ---------ALARVQHKQQQL 1824
E + L W +L + + L A E R + R Q L
Sbjct: 2725 ERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQAL 2784
Query: 1825 PD-----GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879
P GT R+L AA + R +AL Q Q +GH L A+++
Sbjct: 2785 PGVGELLGTQRELEAAVDKKARQA------EALLGQAQAFVREGHCL--------AQDVE 2830
Query: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDV 1939
+ + + + L+ RR L + +FF+ E M W+ E AQ+ + +
Sbjct: 2831 EQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSL 2890
Query: 1940 SSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQ------- 1992
S+ + + Q +++E+ + + G +L+ H+AA E++ ++ QL+
Sbjct: 2891 SAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLR 2950
Query: 1993 ---ARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVE 2049
ARR+ ++ QE +L +LE A +WL + ++ S ++G + + +
Sbjct: 2951 AEAARRRLLLQQAQEAQQFLTELLE----------AGSWLAERGHVLDSEDMGHSAEATQ 3000
Query: 2050 SLIKRHEAFQKSAVAWEERFCALEKLTALEEREK 2083
+L++R EA ++ A+ R L++ AL E K
Sbjct: 3001 ALLRRLEATKRDLEAFSPRIERLQQTAALLESRK 3034
Score = 276 bits (707), Expect = 1e-73
Identities = 420/1956 (21%), Positives = 757/1956 (38%), Gaps = 98/1956 (5%)
Query: 430 FDRKAAMRETWL-SENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVA 488
F R+A + WL S+ Q ++ G + K + + S RV A +A
Sbjct: 1700 FLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLA 1759
Query: 489 AELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWME 548
L + + RQ ++ W L ++ AR L +V +DLL ++ ++
Sbjct: 1760 ESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQ 1819
Query: 549 EMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCD 608
E L + ++ R L G+E L+ H+ +E ++ +++ + +A G+ + C
Sbjct: 1820 EKATSLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETA------GRVQKLCP 1872
Query: 609 -PQL--VSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWV-REQQHLL 664
PQ V +R + Q++ L RRA+LE +R L RF V + +W R +Q L
Sbjct: 1873 GPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQ 1932
Query: 665 ASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQ-LVAEGHPGASQASARAA 723
+ +G L+L + H LR E+ R + + GQQ L+A G P +
Sbjct: 1933 VEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTP-TKEVQEELR 1990
Query: 724 ELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQ 783
LQ Q +++ + +RL F + +E L + + LG +
Sbjct: 1991 ALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVE 2050
Query: 784 ALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGE 843
L R+H + + + ALRE+ L R P V+ R+P L + ++ A
Sbjct: 2051 QLIRKHEVFLKVLTAQDKKEAALRERLKTL-----RRPRVRDRLPILLQRRMRVKELAES 2105
Query: 844 RARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNT 903
R AL A+L + + A W++ Q L P L D + + E E+
Sbjct: 2106 RGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
Query: 904 LAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNY 963
+T+V E LL + P + + L W+ R+ + L + +
Sbjct: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
Query: 964 HLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLA---GTERDLEAIAARVGELTR 1020
+AW++EK +V + LG DL L L+R+L G A + ++
Sbjct: 2226 LQRVDLAEAWIQEK-EVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISD 2284
Query: 1021 EANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAW 1080
+ L P + I R ++ W + R ++ L A + R LD+
Sbjct: 2285 LSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKR 2344
Query: 1081 LGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR-DQADPQ 1139
+ + + + + L + LL +H L EV Q++ + +L EV R Q P+
Sbjct: 2345 IQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQ---VESLEREVGRLCQRSPE 2401
Query: 1140 CLF-LRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHT 1198
LR R + + W +L + R+ L H Q A E ++S+Q
Sbjct: 2402 AAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKL--QAMLQELLVSAQRLRAQMD 2459
Query: 1199 EMPGTLQAADAA--IKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSI 1256
P +A +++ ++ + +D+ + I G+QL++ G+ + IR+ +
Sbjct: 2460 TSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGL 2519
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT-AQDVSYDEARNLHTK 1315
E+ + A Q+ +L+ E Q FL +++ W+ K + A + +D +
Sbjct: 2520 EQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPL 2579
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLE-KPELKALVSEKLRDLHRRWDELETTTQA 1374
KH+ +L + ++ R L PE ++ + L R+ + L
Sbjct: 2580 LWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRK-EALFRQAGT 2638
Query: 1375 KARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK-DLTSVNILLKKQQMLEWEMA 1433
+ L + + + F Q + +WL + L + + G D + L+KQQ + E+
Sbjct: 2639 RRHRLEELRQLQAFLQDSQEVAAWLR--EKNLVALEEGLLDTAMLPAQLQKQQNFQAELD 2696
Query: 1434 VREKEVEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRLQASREQHQ 1492
+ + +Q + + L Q A E ++ + + L +++ +LQ + E +
Sbjct: 2697 ASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALR 2756
Query: 1493 FHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQR 1552
R +E+ W+ + G+ LP V L+ + L+ + R+ +
Sbjct: 2757 LRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD------KKARQAEA 2810
Query: 1553 ALGAAAA----GPELAE--------LQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA 1600
LG A A G LA+ L + +K L L+ R LE +F+RDA E
Sbjct: 2811 LLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEE 2870
Query: 1601 EAWMGEQELHMMGQEKAKDELSAQAEVKK-HQVLEQALADYAQTIHQLAASSQDMIDHEH 1659
AW+ +++L + + LSA +++ HQ LE ++ + + + ++ H
Sbjct: 2871 MAWV-QEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGH 2929
Query: 1660 PESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAAS 1719
+ ++ R Q++K A L+ A RR LQ+ Q EL + W+ ER V S
Sbjct: 2930 FAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDS 2989
Query: 1720 HELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSL 1779
++G E L + RD R++ A L + + V ++
Sbjct: 2990 EDMGHSAEATQALLRRLEATKRDLEAFSP-RIERLQQTAALLESRKNPESPKVLAQLQAV 3048
Query: 1780 NEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGT-GRDLNAAEAL 1838
EA A+LL + RG L +L + A + K G+DL + L
Sbjct: 3049 REAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVL 3108
Query: 1839 QRRHCAYEHDIQALSP-QVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSA 1897
+ + A+ ++Q+L +V ++ L++ A + I + AW +L +
Sbjct: 3109 EEKFDAFRKEVQSLGQAKVYALRKLAGTLERG-APRRYPHIQAQRSRIEAAWERLDQAIK 3167
Query: 1898 ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIE 1957
AR + L + F +A EL M E M ++ +SS + + + ++ E+E
Sbjct: 3168 ARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELE 3227
Query: 1958 ARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLV 2017
A + + L + H AA K+ + A Q A QE+ WL +
Sbjct: 3228 AMEKEVAR-LQTEACRLGQLHPAAPGGLAKVQEAWATLQAKA---QERGQWLAQAAQGHA 3283
Query: 2018 FGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAF----------------QKS 2061
F AW ++ L S EL V E L+ +HE +
Sbjct: 3284 FLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQ 3343
Query: 2062 AVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTASDT 2121
+ F + E L+E E R ++ EE + E + A
Sbjct: 3344 QLVDNSHFMSAEVTECLQELEG-RLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLA 3402
Query: 2122 TWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEANGPRGE 2181
W+G +P V + + + LL Q + + + + +
Sbjct: 3403 CWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT------EMEQELLLQ 3456
Query: 2182 RQTRTRGPAPSAMPQSRSTESAH----AATLPPRGPEPS-AQEQMEGMLCRKQEMEAFGK 2236
Q G A S++ + S H A R P+ + MEG L KQ + G+
Sbjct: 3457 PQELKPGRAGSSLTSFQWRPSGHQGLGAQLAETRDPQDAKGTPTMEGSLEFKQHLLPGGR 3516
Query: 2237 KAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVF 2296
+ ++ SW + L+ SL + D + A+ V + ++ AR + RKH F
Sbjct: 3517 QPSSSSWDSCRGNLQGSSLSLFLDERMAAEKVASIALLDLTGARCERLRG--RHGRKHTF 3574
Query: 2297 KLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASS 2332
L L G E LF A E + SW R + + A + S
Sbjct: 3575 SLRLTSGAEILFAAPSEEQAESWWRALGSTAAQSLS 3610
Score = 269 bits (687), Expect = 3e-71
Identities = 317/1399 (22%), Positives = 573/1399 (40%), Gaps = 84/1399 (6%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSY 350
K + + HA+ A L+ + A++ WI+ L + L +++L+ +
Sbjct: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDL---RDKLKPLLKH 2156
Query: 351 RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRL---ISDINKAWERLEKAEH 407
+ E E E ++ ++ K A + + PR G + + + K WE L +A
Sbjct: 2157 QAFE-----AEVQAHEEVMTSVAKKGEALLAQSH-PRAGEVSQRLQGLRKHWEDLRQA-- 2208
Query: 408 ERELALRTELI--RQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLEL---AAVEA 462
+ALR + + R+ LE F ++ + E W+ E + ++ + G +L +
Sbjct: 2209 ---MALRGQELEDRRNFLE-----FLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRR 2260
Query: 463 AVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAA 522
+R+ ++++ ++ +L ++K I R+ + W +
Sbjct: 2261 RLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLR 2320
Query: 523 RRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAV 582
+++L LE+ + ++L + ++E + +Q+ D G+ L V+ LL+ HE +E ++
Sbjct: 2321 YQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHP 2380
Query: 583 QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642
+V ++ R C Q E L + + E R+R ++ R
Sbjct: 2381 IQAQVESLEREVGRLC-----------QRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
Query: 643 LWRFLWEVGEAEAWVRE----QQHLLASADTG---RDLTGALRLLNKHTALRGEMSGRLG 695
L + + +A ++E Q L A DT R A R+L +H + E+
Sbjct: 2430 ALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTD 2489
Query: 696 PLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQAD 755
+ L GQQL+ GHP +S A L+ + LE +E +L QA L F +
Sbjct: 2490 SISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSS 2549
Query: 756 ANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPP 815
ME WL ++S L + L +H+ LE ++ + AL A L
Sbjct: 2550 VEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQ 2609
Query: 816 TLSRTPEVQ---GRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKE 872
PE Q GR + E L +AG R LE L L ++ W+ EK
Sbjct: 2610 --GGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK- 2666
Query: 873 QWLNGLALPERLED---LEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRI 929
N +AL E L D L Q+ + + E++ Q + ++LL+ P + I
Sbjct: 2667 ---NLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
Query: 930 VNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGN 989
E+L W + + + K A L A E + W+ E +V +G
Sbjct: 2724 QERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWL-EPIEVELRAPTVGQ 2782
Query: 990 DLAGVLALQRKLAGTERDLEAI----AARVGELTREANALAAGHPAQAVAINARLREVQT 1045
L GV +L GT+R+LEA A + L +A A A + + R +
Sbjct: 2783 ALPGV----GELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838
Query: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105
++ LR ++ R +L L F R D+ AW+ A+++ +L L
Sbjct: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
Query: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF-LRQRLEALGTGWEELGRMWESR 1164
QH L E E + E LG QA + R++ L L R
Sbjct: 2899 QHQNL--ESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARR 2956
Query: 1165 QGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDAN 1224
+ L QA Q FL + +A L+ + +VL +M + +A A +++LE ++A
Sbjct: 2957 RLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
Query: 1225 GERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
RI L + L S N + K+ + ++ H + A+ L++ +
Sbjct: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
Query: 1285 QDCHELKLWIDEKMLTAQDVSY-DEARNLHTKWQKHQAFMAEL-AANKDWLDKVDKEGRE 1342
++ L W+ K TA+ Y + + +K AF E+ + + + + K
Sbjct: 3077 RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGT 3136
Query: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402
L P + + + W+ L+ +A+ +L A+ F Q+ L+ ++
Sbjct: 3137 LERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK 3196
Query: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA-GEVER 1461
A + +D G L+SV L ++ + LE E+ EKEV +Q +A L Q A G + +
Sbjct: 3197 TALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAK 3256
Query: 1462 TSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLP 1521
V+E + L +ER + L + + H F ++ + W ER +ASS E +D+
Sbjct: 3257 ----VQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVA 3312
Query: 1522 SVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL--GAAAAGPELAE-LQEMWKRLGHELE 1578
+ L+ +++ L +EI+ + DLR+ + L + E+ E LQE+ RL ELE
Sbjct: 3313 GAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRL-QELE 3371
Query: 1579 ----LRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLE 1634
LR +R ++ Q+ + +AEAW+ E ++ + + + +HQ LE
Sbjct: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
Query: 1635 QALADYAQTIHQLAASSQD 1653
+ LA + Q+ + +
Sbjct: 3432 KLLAAQEEKFAQMQKTEME 3450
Score = 241 bits (615), Expect = 6e-63
Identities = 273/1311 (20%), Positives = 524/1311 (39%), Gaps = 86/1311 (6%)
Query: 867 WVEEKEQWLN-GLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPG 925
++++ EQ L+ A P L +E QR LE + + A+ +IA+ L +
Sbjct: 406 FLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHS 465
Query: 926 KDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQ 985
+ QE++ RWQ+ + G++ + ++ + E + E + ST
Sbjct: 466 WADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARST- 524
Query: 986 GLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQT 1045
G LA V+ L ++ E + A A V L ++ L + + A+ R +
Sbjct: 525 ACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQ 584
Query: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105
+ L A +R R L + + +FLR+ ++ +AWL V + L + L
Sbjct: 585 LQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQ 644
Query: 1106 QHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFLRQRLEALGTGWEELGRMW 1161
+H AL EV R Q+ L G +++ Q DP +R EA+ GW+ L
Sbjct: 645 KHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-----ERAEAVQGGWQLLQTRV 699
Query: 1162 ESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-----------------HTEMPGTL 1204
R RL A + DA +A L + L H + L
Sbjct: 700 VGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVL 759
Query: 1205 QAADAAIKKLEDFMSTMDANGERI---HGLLEAGRQLVSEG------------------- 1242
+A A +++LE+ A L G L + G
Sbjct: 760 RAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMAL 819
Query: 1243 ------NIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDE 1296
+ + I + D + + ++ + AQ RL + F C EL+LW+++
Sbjct: 820 PAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEK 879
Query: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356
+ + Q V +A L K++ F+ LA K +V +L P +
Sbjct: 880 QTVLLQRVQ-PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQR 938
Query: 1357 KLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
+ +L +RW +LE + KA L + F Q C + L + QL + G
Sbjct: 939 QQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSED 998
Query: 1417 SVNIL-LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQ 1475
+ + L L +++ L E V + ++ + A+ G+VE ++ + + +
Sbjct: 999 TCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVE----TLQGLLKQVQE 1054
Query: 1476 PMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQK 1535
+ +R RR ++ + F ++ + +LW S E D+ S Q L++++Q L +
Sbjct: 1055 QVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLE 1114
Query: 1536 EIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE-------LELRGKRLEDAL 1588
EI + R+ L + + + AA P+ E+ + LG + E R + L++ L
Sbjct: 1115 EIHLWQERLQQLDAQSQPM-AALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGL 1173
Query: 1589 RAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLA 1648
Q+F R+ A + + +D A + +++H+ + L+ L
Sbjct: 1174 ELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALR 1233
Query: 1649 ASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQ 1708
A + ++ +HP + + + + + L+ + +RR +L L+L + ++++ +L Q
Sbjct: 1234 AHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293
Query: 1709 WIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAA 1768
W++E+ ++AA G + L K E + + V++ + L++
Sbjct: 1294 WMEEKGLMAAHEPSGARRNILQTL--KRHEAAESELLATRRHVEALQQVGRELLSRRPCG 1351
Query: 1769 RATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG- 1827
+ + L W L + RG L A + ++ L + A +++ + L
Sbjct: 1352 QEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSE 1411
Query: 1828 TGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAE 1887
TG+DL +++ LQ+RH E + + L+ ++ + H + + A EE +H++ +
Sbjct: 1412 TGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA--ILEETQKHLRRLE- 1468
Query: 1888 AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIK 1947
LQG A R L + + +F + W+ E ++ A + +
Sbjct: 1469 ---LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHR 1525
Query: 1948 NQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMD 2007
+ ++ E++A + + G+ L A H A+ I E+ +L+ E + +
Sbjct: 1526 KHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQ 1585
Query: 2008 WLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS-AVAW- 2065
LQ + + D E W+ + PLV S + G LI +H+A Q+ A+ W
Sbjct: 1586 CLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWS 1645
Query: 2066 --EERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVG 2114
EE + LT E E++R +E R+Q A + A+ +L G
Sbjct: 1646 SMEELDQTAQTLTGPEVPEQQRV---VQERLREQLRALQELAATRDRELEG 1693
Score = 241 bits (615), Expect = 6e-63
Identities = 377/1841 (20%), Positives = 706/1841 (38%), Gaps = 131/1841 (7%)
Query: 301 MEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKP---- 356
++ LV +Y + A+E W+ + +L + + L+ V +
Sbjct: 706 LQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAE 765
Query: 357 -PKFTEKG---NLEVLLFTIQSKLRANNQKVYTP---REGRLISDINKAWERLEKAEHER 409
+ E+G + LFT+ S L + + P E AW+ AE +
Sbjct: 766 LRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDP 825
Query: 410 ELALRTEL------------------IRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
+ T L +R+ +LE+ A F ++ E L ++ V
Sbjct: 826 DFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQ 885
Query: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
+ +E K+E T + G V + A +L + +I +Q +++
Sbjct: 886 RVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQ 945
Query: 512 LWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQ 571
W L + + +L ++E+ Q+ + ++ +L++ G ED
Sbjct: 946 RWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPG----SSEDTCH 1001
Query: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
+L + V RV + + ++ PG + Q + +V L+ + + E A
Sbjct: 1002 ALQLAQKKTLVLERRVHFLQSVVVKVEEPGY----AESQPLQGQVETLQGLLKQVQEQVA 1057
Query: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
R R E++ FL E + W Q L S + D+ A RLL +H L E+
Sbjct: 1058 QRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIH 1117
Query: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
L+ Q Q + A P + + L Q + L+ L E+R Q L + L +
Sbjct: 1118 LWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK 1177
Query: 752 FQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAA 811
F + + A + + LG D +L +QHR + + P +ALR
Sbjct: 1178 FGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGE 1237
Query: 812 ALPPTLSRTP---EVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWV 868
L S+ P V+ ++ +++ + LQ R+ +R R L A+L L + W+
Sbjct: 1238 KL--VQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWM 1295
Query: 869 EEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDR 928
EEK R L+ + +R E E E+ + A+ + +LL P G++
Sbjct: 1296 EEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED 1354
Query: 929 IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988
I + L +W+ R + L A + + + + + + ++S++ G
Sbjct: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSE-TG 1413
Query: 989 NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048
DL LQ++ E + +AA++ L A+ +AA PA LR + E
Sbjct: 1414 QDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL----E 1468
Query: 1049 DLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108
L+ + R L + L F + +W+ + L A++L +H
Sbjct: 1469 LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHK 1528
Query: 1109 ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
L+ EV+ Q + R+ + G + PQ + ++ + L W EL R E+R L
Sbjct: 1529 ELQVEVKAHQGQVQRVLSSGRSLAA-SGHPQAQHIVEQCQELEGHWAELERACEARAQCL 1587
Query: 1169 AQAHGFQGFLRDARQAEG-------VLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTM 1221
QA FQ + D + EG ++SS++Y + A ++L + S+M
Sbjct: 1588 QQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSM 1647
Query: 1222 DANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ 1281
+ + L G ++ + + +++RE+ ++ Q+ A L
Sbjct: 1648 EELDQTAQTL--TGPEVPEQQRVVQERLREQLRAL-------QELAATRDRELEGTLRLH 1698
Query: 1282 HFLQDCHELKLWIDEKMLTA---QDVSYDEARNLH--TKWQK--HQAFMA--ELAANKDW 1332
FL++ +L+ W+ + A + + D LH TK+ K HQ M +AA +
Sbjct: 1699 EFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLL 1758
Query: 1333 LDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSC 1392
+ + + G +V ++ +DL W EL TQA+ +L D +
Sbjct: 1759 AESLLERGH-------SAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDL 1811
Query: 1393 CALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQE 1452
+ + ++ L ++ +DL + L+ Q LE E+ E++++ + A + +
Sbjct: 1812 LEVLTQVQEKATSL-PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKL 1870
Query: 1453 DQG--AGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPM 1510
G A V++ +AV + + L + M +R +L+ +R +F V D W
Sbjct: 1871 CPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQD 1930
Query: 1511 ASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGP------ELA 1564
E ++ S L + +Q L+ E++ E + + AA P EL
Sbjct: 1931 LQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELR 1990
Query: 1565 ELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQ 1624
LQ+ ++ + +RL+ + Q F R+ E + QE+ + +
Sbjct: 1991 ALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVE 2050
Query: 1625 AEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAG 1684
++KH+V + L AQ + AA + + P R+ R + + +KELA
Sbjct: 2051 QLIRKHEVFLKVLT--AQDKKE-AALRERLKTLRRP---RVRDRLPILLQRRMRVKELAE 2104
Query: 1685 ERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTS 1744
R L L + + E WIQ A + +L + LRDK + + +
Sbjct: 2105 SRGHALHASLLMASFTQAATQAEDWIQ-----AWAQQLKEPVPPGD-LRDKLKPLLKHQA 2158
Query: 1745 -----TIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAA 1799
+E + S L+A H V++ L + W DL + + RGQ L
Sbjct: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
Query: 1800 AYELQRFLHGARQALARVQHKQQQLPDG-TGRDLNAAEALQRRHCAYEHDIQALS---PQ 1855
FL A A +Q K+ ++ G G+DL L+RR + + +
Sbjct: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
Query: 1856 VQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA 1915
++ + D +L K ++ + I + + WA G+ +Q L + +
Sbjct: 2279 IRSISDLSLQL-KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRE 2337
Query: 1916 VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLA 1975
+ + + E + A + +D+ S +++ + ++ E+ + S L
Sbjct: 2338 LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQ 2397
Query: 1976 RSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPL 2035
RS AA L+ R+QE AE W + Q E L A +A L QE L
Sbjct: 2398 RSPEAAH-------GLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML--QELL 2448
Query: 2036 VRSAELGCTVD---------EVESLIKRHEAFQKSAVAWEE 2067
V + L +D E +++ H+ + +W +
Sbjct: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTD 2489
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 565 bits (1455), Expect = e-160
Identities = 447/1777 (25%), Positives = 794/1777 (44%), Gaps = 137/1777 (7%)
Query: 314 ASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ 373
+ EL W+ + + T D + S +Q ++Q ++ +
Sbjct: 582 SDELKSWVNEKMKTATDEAYKDP-SNLQGKVQKHQAF----------------------E 618
Query: 374 SKLRANNQKVYT-PREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAAR--- 429
++L AN ++ + G+ + D+N + A ++L +L+ +L+ + R
Sbjct: 619 AELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN 678
Query: 430 ----FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVD 485
F+R E WL E + ++ D++G +L V+ +KH +E D+ A+ R+ +
Sbjct: 679 QQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGIT 738
Query: 486 AVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD 545
A + + D + I +Q + ++ L++ + AR+++L +L LQ++F+D+
Sbjct: 739 IQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEET 798
Query: 546 WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR 605
W+ E + S + G+ L GV++LL+ H+ ++A+IA R++AV+ G
Sbjct: 799 WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH--- 855
Query: 606 PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665
+ V ++ +L Q +EAL A+ RR LE+S + ++ + EAE+W+RE++ ++
Sbjct: 856 -FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVG 914
Query: 666 SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAA-- 723
S D G+D A LL KH AL ++S ++ EQ Q + P +
Sbjct: 915 STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLA 974
Query: 724 --ELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFS 781
+ Q + R + + L + + ++ + ND + ++ A
Sbjct: 975 LYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY-------------- 1020
Query: 782 TQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARA 841
+ L A E + + ++ +EQ V R+ +E Y L
Sbjct: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
Query: 842 GERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEM 901
+R LE + + + EA W+ EKE L + LE +EV+Q++F+ + ++
Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
Query: 902 NTLAAQITAVNDIAEQLLK-----------------------------ANPPGKDRIV-- 930
+++ +N +AE L A+P R++
Sbjct: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
Query: 931 -----NTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQ 985
N+ ++LN RW+ ++LA+ + L SA +Q +H + ET+ W+ EK + + +T
Sbjct: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL-NTD 1259
Query: 986 GLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQT 1045
G+DLA V ALQRK G ERDL A+ +V L A L HP A + + E+
Sbjct: 1260 NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQ 1319
Query: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105
W L +R+ LG++ LQ FL D +W+ + V+S+E + AEALL
Sbjct: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLE 1379
Query: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRD--QADPQCLFLRQRLEALGTGWEELGRMWES 1163
+H R E++ + G+++ A P+ ++Q+L+ L +L + W
Sbjct: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQKLDILDQERADLEKAWVQ 1436
Query: 1164 RQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDA 1223
R+ L Q Q F RD QAE ++++E L+ + +L + +A IKK EDF ++
Sbjct: 1437 RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINV 1496
Query: 1224 NGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHF 1283
E+I L QL++ G+ I + + + R ++ + + +L +++ Q F
Sbjct: 1497 QEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQF 1556
Query: 1284 LQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGREL 1343
+D E++ WI EK+ TA D SY + N+ +K QKHQAF AEL AN D + V G L
Sbjct: 1557 SRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSL 1616
Query: 1344 TLEKPEL---KALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLE 1400
+E+ + V +L L +W L + K++ L +AN+ + F + WL
Sbjct: 1617 -IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1675
Query: 1401 SLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ-GAGEV 1459
++A L S+DYGKDL SVN LLKK Q+LE +++ E ++ + +QA +L +V
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1735
Query: 1460 ERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKD 1519
+ + +F+ + R +L S HQF RD++DE W+ E+ + S ++G+D
Sbjct: 1736 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1795
Query: 1520 LPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQEMWKRL 1573
L VQ L KK++ L+ E+ HEP I + + + L G LA+ E WK L
Sbjct: 1796 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1855
Query: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEVKKHQV 1632
RG+RLE++L QQF + E EAW+ E ++ ++ E D L+A Q +KKH+
Sbjct: 1856 KQLAAARGQRLEESLEYQQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEA 1914
Query: 1633 LEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQE 1692
E + ++ + + QD+I + IS + ++ + L++ A +R+ +L E
Sbjct: 1915 FETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1974
Query: 1693 HLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVD 1752
+ Q + D +E WI E+E + + G+D V L K F QE +
Sbjct: 1975 NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIA 2034
Query: 1753 SANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQR-----FL 1807
+ AL + L+A H + SL + W+ LL R + L A R FL
Sbjct: 2035 NITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2094
Query: 1808 HGARQALA---RVQHKQQQLPDGTG-RDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDG 1863
A++A A ++ ++ L D L +AL+ H A+ + + Q+ +
Sbjct: 2095 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELD 2154
Query: 1864 HRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAAR------RQLLLDTTDKFR--FFKA 1915
++ K++ M+A+ E W LQ R Q + DK R F +
Sbjct: 2155 RQI-KSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQH 2213
Query: 1916 VRELMLWMDEVNLQ-MDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMG---K 1971
W+ E +D + + + ++ + EI A + D+G +
Sbjct: 2214 ANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAME 2273
Query: 1972 ELLARSHYAAEEIS-------EKLSQLQARRQETAEK 2001
E L + E + ++L QL R Q E+
Sbjct: 2274 EALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2310
Score = 521 bits (1341), Expect = e-147
Identities = 384/1412 (27%), Positives = 668/1412 (47%), Gaps = 75/1412 (5%)
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774
A R ++ ++ R + L+ R Q+L + FQ DA ++E W+ + L+ ++S E
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASDE 70
Query: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERH 833
D + Q ++H+A E E++++ + L E + E ++ R+ L R
Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893
+E L + E+ L A L L E W+ +KE + L + LE +EV+Q++
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 894 FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953
FE + +M ++ VN A +L++ P ++ I Q+++N WQ+ + LA ++
Sbjct: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
Query: 954 LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013
L A +Q ++ + ET +W++EK +++ S G DLA V AL RK G ERDL A+
Sbjct: 251 LFGAAEVQRFNRDVDETISWIKEKEQLMASDD-FGRDLASVQALLRKHEGLERDLAALED 309
Query: 1014 RVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRS 1073
+V L EA+ L HP A I + E+ T WE +R R L ++ RLQ FL
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 1074 LDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR 1133
D +W+ + + ++E + + AEALL +H +GE++ + + G+ +
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 1134 --DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQ 1191
A + +R++L L L +WE R+ + Q Q F RD Q + +S Q
Sbjct: 430 AGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
Query: 1192 EYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
E L + ++ +L + +A +KK EDF ++ A E+I L E +L+ + + +
Sbjct: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARN 1311
+ D++ R + A + +L D+ Q F +D ELK W++EKM TA D +Y + N
Sbjct: 547 RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
Query: 1312 LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETT 1371
L K QKHQAF AEL+AN+ +D ++K G++L K V+ ++ ++ W +L
Sbjct: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWE 1431
T+ K L +AN+ + F ++ +E WL ++ L SDDYGKDLT+V L KK +LE +
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
Query: 1432 MAVREKEVEAIQAQAKALAQEDQG---AGEVERTSRAVEEKFRALCQPMRERCRRLQASR 1488
+A + ++ I QA+ +D G A +++ A+ ++ AL +PM R ++L S
Sbjct: 727 VAAHQDRIDGITIQARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
Query: 1489 EQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR 1548
Q RDVEDE W+ E+ P+A+S GKDL VQ L+KK+Q LQ EI GHEPRI +
Sbjct: 785 RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT 844
Query: 1549 ERQRAL------GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEA 1602
++ A+ A +L EL + W+ L + R + LED+L+AQQ++ DA EAE+
Sbjct: 845 QKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
Query: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-- 1660
WM E+E + + KDE SA+A +KKH+ L L+ Y +I L +Q P
Sbjct: 905 WMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRE--RLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
+ T + A D +E+ ++ + L + E++D + ++ V
Sbjct: 965 DETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV--K 1022
Query: 1719 SHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDS 1778
+ Q +L + + + + QE++D+ + AG + R E
Sbjct: 1023 KLDPAQSASRENLLEE------QGSIALRQEQIDNQTRITKE--AGSVSLRMKQVE---- 1070
Query: 1779 LNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEA 1837
E + LLEL + R +L + + A + + K+ L + G DL E
Sbjct: 1071 --ELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 1838 LQRRHCAYEHDIQA-------LSPQVQQVQDDGHRLQKAYAGDKAEEIG----------- 1879
LQ++ ++ D++A ++ + ++ +G ++ A + E G
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 1880 -----------------RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLW 1922
++ + E W LQ + R QLL + RF + E W
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
Query: 1923 MDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAE 1982
++E N ++ D++S + + +G + ++ A D+ +S + + L+ +AE
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308
Query: 1983 EISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELG 2042
++ EK ++L ++ ++ L ++ F D +W+ LV S EL
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
Query: 2043 CTVDEVESLIKRHEAFQKSAVAWEERFCALEK 2074
V E+L++RH+ + A F A E+
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Score = 499 bits (1284), Expect = e-140
Identities = 394/1525 (25%), Positives = 705/1525 (46%), Gaps = 97/1525 (6%)
Query: 612 VSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR 671
+ ER ++ Y EL+ RR +LE+S R F + E E W++E+ + AS + +
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI-ASDENYK 73
Query: 672 DLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWER 731
D T L KH A E+ G + E G +++EGH + R EL QWE
Sbjct: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
Query: 732 LEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRA 791
L E+ +L QA L Q+ + D+ W+ D +V+S ELG D + L ++
Sbjct: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 792 LEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERHYEELQARAGERARALEA 850
+ ++ +H ++ + + AA L E ++ + + ++ L+ A +R L
Sbjct: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
Query: 851 ALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITA 910
A + + W++EKEQ + L ++ + ++ E LE ++ L ++ A
Sbjct: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
Query: 911 VNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTET 970
+ A++L +++P +I +E+L W+Q R LA + A L + +Q + + +
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
Query: 971 QAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL-AAGH 1029
+W+ E +I + + L +D+AG AL + + +++A AL AAGH
Sbjct: 374 TSWVTEMKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRR----REESLGEARRLQDFLRSLDDFQAWLGRTQ 1085
A + +RE T + RA + R + + LQ F R + W+ + +
Sbjct: 433 YA-----SDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF--L 1143
+ +E+ +L EALL +H + AQ E ++ AL E T+ + +
Sbjct: 488 AFLLNEDLGDSLDSVEALLKKHEDFEKSLS-AQEE--KITALDEFATKLIQNNHYAMEDV 544
Query: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM--P 1201
R +AL + L R+ +LA + Q F RD+ + + ++ + + P
Sbjct: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP 604
Query: 1202 GTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHK 1261
LQ ++K + F + + AN RI L +AG++L+ + D++ + + + K
Sbjct: 605 SNLQGK---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWK 661
Query: 1262 KNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKM--LTAQDVSYDEARNLHTKWQKH 1319
K +A + +LR+ +QQ F ++ +++LW+ E L + D D N+ +KH
Sbjct: 662 KLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKH 720
Query: 1320 QAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
A++AA++D +D + + R+ + +K L R++ L+ A+ + L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D+ R + + E+W+ + S + GKDL V LLKK Q L+ E+A E +
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 1440 EAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVE 1498
+A+ + A+ +E A E V+ + +K+ AL +R + L+ S + Q+ D
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 1499 DEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAA 1558
+ W+ E+ P+ S ++GKD S + L+KK++ L ++ + I LRE+ ++
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
Query: 1559 AGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAK 1618
A + G EL L A Y++ + E M + ++ + K
Sbjct: 961 APTD--------DETGKELVL----------ALYDYQEKSPREVTMKKGDILTLLNSTNK 1002
Query: 1619 DELSAQ----------AEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEH---PESTRI 1665
D + A VKK + A + A Q+ ID++ E+ +
Sbjct: 1003 DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSV 1062
Query: 1666 SIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQD 1725
S+R QV++LY L EL +R+ L++ + L RE ++L+QWI E+E S E+G D
Sbjct: 1063 SLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGAD 1122
Query: 1726 YEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA--------------- 1770
E V +L+ KF +F +D + R+ N +A L + G A
Sbjct: 1123 LEQVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPR 1181
Query: 1771 ------TVAEWKDS---------------LNEAWADLLELLDTRGQVLAAAYELQRFLHG 1809
T + WK + LNE W L +L + R Q+L +A+E+QRF
Sbjct: 1182 DETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRD 1241
Query: 1810 ARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK 1868
A + ++ K Q L D G DL + +ALQR+H +E D+ AL +V + + RL +
Sbjct: 1242 ADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQ 1301
Query: 1869 AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNL 1928
++ + AE++ + +AW+ L + R+ L D+ D RF R+LM W++ +
Sbjct: 1302 SHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRG 1360
Query: 1929 QMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKL 1988
+ + E +DV+ A+ +++ Q + EI+ARA F + G++LLA HYA+ EI +KL
Sbjct: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
Query: 1989 SQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEV 2048
L R + + W ++ L LE+ +F RD AE W+ ++E + + + G ++D V
Sbjct: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
Query: 2049 ESLIKRHEAFQKSAVAWEERFCALE 2073
E+LIK+HE F K+ EE+ AL+
Sbjct: 1481 EALIKKHEDFDKAINVQEEKIAALQ 1505
Score = 447 bits (1149), Expect = e-125
Identities = 396/1719 (23%), Positives = 752/1719 (43%), Gaps = 108/1719 (6%)
Query: 418 IRQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIV 475
+R++KLE F R A E W+ E ++ S +N+ + ++ ++KH+A E ++
Sbjct: 35 LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
Query: 476 AYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQK 535
A SG + +D + +E + + I R + R W+ L + + + +LL +L +
Sbjct: 94 ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
Query: 536 VFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASAL 595
++ +MDW+ + + + S++LG+ L VE L + E + D+A ERV V+ A
Sbjct: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
Query: 596 RFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEA 655
+ +E P + +L+ + ++ +++ L LA R+ +L + + RF +V E +
Sbjct: 214 KLI---QEQHP-EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
Query: 656 WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHP-G 714
W++E++ L+AS D GRDL LL KH L +++ +K + +L + HP
Sbjct: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL-QQSHPLS 328
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774
A+Q + EL WE++ LA ER RL + L +F AD D+ +W+ + L+++ E
Sbjct: 329 ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
Query: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQA-AALPPTLSRTPEVQGRVPTLERH 833
L D +AL +H+ + EI +H + + E A L + EV+ ++ L
Sbjct: 389 LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEE 448
Query: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893
L R + E + L + W+ ++E +L L + L+ +E + ++
Sbjct: 449 RAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKK 508
Query: 894 FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953
E E ++ +ITA+++ A +L++ N + + ++ L R A ++A
Sbjct: 509 HEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQ 568
Query: 954 LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013
L + +Q + + E ++W+ EK K +T D + + +K E +L A +
Sbjct: 569 LADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQS 626
Query: 1014 RVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRS 1073
R+ L + L + + AR+ EV + W+ L + L EA + Q F R+
Sbjct: 627 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN 686
Query: 1074 LDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR 1133
++D + WL + +AS++ L + L +HA L +V Q + + +
Sbjct: 687 VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF-Q 745
Query: 1134 DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEY 1193
D ++++ EAL +E L +R+ +LA + Q RD E + +E
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
Query: 1194 VLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKA 1253
+ + T L +KK + + + + RI + + G +V EG+ A+ ++ K
Sbjct: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
Query: 1254 DSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEK--MLTAQDVSYDEARN 1311
+ ++ + + A Q L D+ + Q + D +E + W+ EK ++ + D DE +
Sbjct: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDE-DS 924
Query: 1312 LHTKWQKHQAFMAELAANKDWLDKV---------------DKEGRELTLEKPELKALVSE 1356
+KH+A M++L+A + + D+ G+EL L
Sbjct: 925 AEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVL----------- 973
Query: 1357 KLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
L D + T + +L ++ + + + ++ + A + D + +
Sbjct: 974 ALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA--AYVKKLDPAQSAS 1031
Query: 1417 SVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQP 1476
N+L + + +A+R+++++ K AG V + VEE + +L +
Sbjct: 1032 RENLLEE-----QGSIALRQEQIDNQTRITKE-------AGSVSLRMKQVEELYHSLLEL 1079
Query: 1477 MRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKE 1536
+R L+ S ++ R+ + W+ E+ +S E G DL V++L KK QK+
Sbjct: 1080 GEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139
Query: 1537 IQGHEPRIADLR-------------------ERQRALG--------AAAAGP-------- 1561
++ +E R+ D+ ++Q G + A P
Sbjct: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
Query: 1562 -------ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQ 1614
+ EL E W+ L E R + L A Q+F+RDA E + W+ E+ +
Sbjct: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
Query: 1615 EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTR-ISIRQAQVD 1673
D S QA +KH+ E+ LA ++ L +++ +I HPES + + +++
Sbjct: 1260 NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELN 1318
Query: 1674 KLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLR 1733
+ ++ L + A +R+ +L + L + + DL WI + +S EL +D L
Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
Query: 1734 DKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
++ +E R + L+A GH A + + D L++ ADL + R
Sbjct: 1379 ERHQE-HRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437
Query: 1794 GQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQAL 1852
+L ELQ F QA + ++ L + G L++ EAL ++H ++ I
Sbjct: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497
Query: 1853 SPQVQQVQDDGHRLQKAYAGDKAE-EIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFR 1911
++ +Q +L AG A+ +I V + W +L+ +R L ++ +
Sbjct: 1498 EEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555
Query: 1912 FFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGK 1971
F + V E+ W+ E LQ + E +D ++ + Q +AE+ A ADR IDMG
Sbjct: 1556 FSRDVDEIEAWISE-KLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGN 1614
Query: 1972 ELLARSHYAAEE--ISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWL 2029
L+ R A E + +L+ L + Q +K EK L+ + F + WL
Sbjct: 1615 SLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWL 1674
Query: 2030 CSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEER 2068
E L+ S + G + V +L+K+H+ + A E+R
Sbjct: 1675 SEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1713
Score = 443 bits (1139), Expect = e-123
Identities = 421/1883 (22%), Positives = 807/1883 (42%), Gaps = 116/1883 (6%)
Query: 259 VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318
+ P+E+ I T + ++K LA++ R GK+ A V+++ E +
Sbjct: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAAE-----VQRFNRDVDETI 268
Query: 319 QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378
WI++ + L+ VQ L+ LE L ++ K++A
Sbjct: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHEG---------------LERDLAALEDKVKA 313
Query: 379 NNQKVYTPREGRLIS---------DINKAWERLEKAEHERELALRTELIRQEKLEQLAAR 429
+ ++ +S ++ WE++ ER L +L++ A
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY----RLQRFLAD 369
Query: 430 FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAA 489
F + W++E + L++ D ++A EA + +H+ + +I A+ ++ D
Sbjct: 370 FRDLTS----WVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
Query: 490 ELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEE 549
L A ++ + + ++ L ++ RR++ ++LQ ++D + +WM +
Sbjct: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
Query: 550 MKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDP 609
+ L ++DLG L VE LL+ HE E ++ Q E++ A+ A + Y D
Sbjct: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ-NNHYAMED- 543
Query: 610 QLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADT 669
V+ R L AL E A RRA+L +S L +F + E ++WV E+ A+ +
Sbjct: 544 --VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT-ATDEA 600
Query: 670 GRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW 729
+D + + KH A E+S + + GQ+L+ H + +AR E+ + W
Sbjct: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 730 ERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQH 789
++L E + +L +A QF + D+E WL + ++S + G D + Q L ++H
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 790 RALEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERHYEELQARAGERARAL 848
LE ++ +H+ +D + QA E ++ + L YE L+ R + L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
+L L + + W+ EKE + L ++ + ++ + L+ E+ +I
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
AV +++ + + +LN +W+ + A ++ L +L Q Y +
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E ++WMREK ++ ST G D AL +K DL A + + L +A +
Sbjct: 901 EAESWMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-- 957
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ-DFLRSLDDFQAWLGRTQTA 1087
Q VA + +TG E + A +E+S E + D L L+ + +
Sbjct: 958 ---QQVAPT----DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-- 1008
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQR- 1146
V +G + L +A R + Q + + + TR + + LR +
Sbjct: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ 1068
Query: 1147 LEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQA 1206
+E L ELG E R+G L ++ R+A + + ++ +E L+ E+ L+
Sbjct: 1069 VEELYHSLLELG---EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQ 1125
Query: 1207 ADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG------------NIHADKIREKAD 1254
+ KK +DF + AN R+ + + L SEG ++ R++ D
Sbjct: 1126 VEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETD 1185
Query: 1255 S------------------------IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHEL 1290
S + R + Q A++ L E Q F +D E
Sbjct: 1186 SKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADET 1245
Query: 1291 KLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP 1348
K WI+EK L + +D A ++ +KH+ F +LAA D ++ + + L P
Sbjct: 1246 KEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP 1304
Query: 1349 ELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS 1408
E + EK +L++ W L + L D++ + F L SW+ ++ + S
Sbjct: 1305 ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSS 1364
Query: 1409 DDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAI-QAQAKALAQEDQGAGEVERTSRAVE 1467
D+ KD+T LL++ Q E+ R +A Q + LA + E+++ ++
Sbjct: 1365 DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILD 1424
Query: 1468 EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLM 1527
++ L + +R L E FHRD E W+ R ++ + G L SV+ L+
Sbjct: 1425 QERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALI 1484
Query: 1528 KKNQTLQKEIQGHEPRIADLR---ERQRALGAAAAGPELA---ELQEMWKRLGHELELRG 1581
KK++ K I E +IA L+ ++ A G A G + E+ + W+RL ++ +
Sbjct: 1485 KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKR 1544
Query: 1582 KRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYA 1641
+L ++ QQF RD E EAW+ E+ L E KD + Q++ +KHQ E L A
Sbjct: 1545 SKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQSKHQKHQAFEAELHANA 1603
Query: 1642 QTIHQLAASSQDMIDHEHPESTR--ISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQL 1699
I + +I+ + + R A + + L + + E+ ++L+E +
Sbjct: 1604 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF 1663
Query: 1700 RRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALAN 1759
+ D + W+ E E + AS + G+D V L K + D S ++R+ N+ A+
Sbjct: 1664 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISA-HEDRLKDLNSQAD 1722
Query: 1760 GLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQH 1819
L+ + V + +D++N + + + +R L ++ L +F + ++
Sbjct: 1723 SLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKE 1782
Query: 1820 KQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEI 1878
K+ + + GRDL + L+++H E ++ A P +Q V D G +L K EEI
Sbjct: 1783 KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGK-EEI 1841
Query: 1879 GRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRD 1938
+ + E W +L+ +AAR Q L ++ + +F V E W++E + +++
Sbjct: 1842 QQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDT 1901
Query: 1939 VSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQET 1998
+++ ++K + + + DR + G++L+ ++++ E IS K+ L + +
Sbjct: 1902 LAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDL 1961
Query: 1999 AEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAF 2058
+ ++ L L F A + E+W+ +E +++ + G + V++L+ + E F
Sbjct: 1962 EKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETF 2021
Query: 2059 QKSAVAWEERFCALEKLTALEER 2081
A+++ + +TAL+++
Sbjct: 2022 DAGLQAFQQE--GIANITALKDQ 2042
Score = 318 bits (814), Expect = 5e-86
Identities = 277/1205 (22%), Positives = 530/1205 (43%), Gaps = 43/1205 (3%)
Query: 929 IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988
I ++Q+ R+ +F+ L+ ++ L + Q + + E + W++EK ++
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
Query: 989 NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048
D + +K E +++A + + +L N + + + I RL E+ WE
Sbjct: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
Query: 1049 DLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108
L MR + L +A++L +LR +D W+ + V SEE L E L +
Sbjct: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 192
Query: 1109 ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
+ ++ + + + ++ ++Q P+ ++ + + + W+ L + RQG+L
Sbjct: 193 EFQTDMAAHEERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
Query: 1169 AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228
A Q F RD + + +E +++ + L + A ++K E + A +++
Sbjct: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKV 311
Query: 1229 HGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCH 1288
L +L + A +I+ K + + ++ + A + RL D+ Q FL D
Sbjct: 312 KALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR 371
Query: 1289 ELKLWIDE-KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK 1347
+L W+ E K L D + +HQ E+ A++D D+ G+ L
Sbjct: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAG 431
Query: 1348 PELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLH 1407
V EKL L L + + + +LF + +++W+ +A L
Sbjct: 432 HYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLL 491
Query: 1408 SDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSR-AV 1466
++D G L SV LLKK + E ++ +E+++ A+ A L Q + A E T R A+
Sbjct: 492 NEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDAL 551
Query: 1467 EEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
+ AL + R +L S QF RD ++ WV E++ A+ E KD ++Q
Sbjct: 552 LSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSNLQGK 610
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQEMWKRLGHELELR 1580
++K+Q + E+ ++ RI L + + L + E+ +WK+L EL+
Sbjct: 611 VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELK 670
Query: 1581 GKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
G +L +A + QQF R+ + E W+ E E H+ + KD + Q KKH +LE +A +
Sbjct: 671 GIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAH 730
Query: 1641 AQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLR 1700
I + ++ D H ++ I +Q + Y LKE R+++L + LRL QL
Sbjct: 731 QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLF 790
Query: 1701 RELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQE-RVDSANALAN 1759
R+++D E WI+E+E +AAS G+D V L K + + + G E R+ + N
Sbjct: 791 RDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA--GHEPRIKAVTQKGN 848
Query: 1760 GLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQH 1819
++ GH A V LN+ W L R Q L + + Q++ A +A + ++
Sbjct: 849 AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
Query: 1820 KQQQLPDGT-GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEI 1878
K+ + G+D ++AEAL ++H A D+ A +Q +++ ++ A +E
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD-DET 967
Query: 1879 GRHMQAVAEAWAQLQGSSAARRQ----LLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQE 1934
G+ + + + ++ LL++T+K + V + ++ ++ +
Sbjct: 968 GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK---KL 1024
Query: 1935 RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQAR 1994
P +S + +++ Q I R ++ + + KE A +S ++ Q++
Sbjct: 1025 DPAQSASRENLLEEQ----GSIALRQEQIDNQTRITKE--------AGSVSLRMKQVEEL 1072
Query: 1995 RQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKR 2054
E +++ L+ + + R+A + W+ +E + S E+G +++VE L K+
Sbjct: 1073 YHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKK 1132
Query: 2055 HEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVG 2114
+ FQK A E R + K+ E+ E E E + ++Q + P D
Sbjct: 1133 FDDFQKDLKANESRLKDINKVA--EDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETD 1185
Query: 2115 GQTAS 2119
+TAS
Sbjct: 1186 SKTAS 1190
Score = 277 bits (709), Expect = 8e-74
Identities = 298/1436 (20%), Positives = 593/1436 (41%), Gaps = 136/1436 (9%)
Query: 390 RLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFD--RKAAMRETWLSENQRL 447
R+ + R+++ E L R+ LE+ +F R+A + W++E +
Sbjct: 1054 RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
Query: 448 VSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
++ + G +L VE +K + + D+ A R++ ++ VA +L +E + A +Q
Sbjct: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
Query: 508 NV-------------------ARL-----------------WDFLRQMVAARRERLLLNL 531
V ARL W L+Q+ R + L
Sbjct: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
Query: 532 ELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVS 591
E+Q+ +D +W+EE L + + G LA V+ L + HE E D+A ++V ++
Sbjct: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
Query: 592 ASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVG 651
+A R + P + + E+ +L Q++ +L + A R+A+L +S L RFL +
Sbjct: 1294 ETAERLI----QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFR 1349
Query: 652 EAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEG 711
+ +W+ + L++S + +D+TGA LL +H R E+ R G + + GQQL+A G
Sbjct: 1350 DLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHG 1409
Query: 712 HPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVS 771
H + + + L + LE +R L Q L F D E W+ ++
Sbjct: 1410 HYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLN 1469
Query: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTP-EVQGRVPTL 830
+ + G S +AL ++H ++ I + AL+ A L ++ R +
Sbjct: 1470 TEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEV 1529
Query: 831 ERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVV 890
+ L+A+ E+ L + L + W+ EK Q A E +D +
Sbjct: 1530 LDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ----TASDESYKDPTNI 1585
Query: 891 Q---QRFETLEPEMNTLAAQITAVNDIAEQLLK--ANPPGKDRIVNTQEQLNHRWQQFRR 945
Q Q+ + E E++ A +I V D+ L++ A +D + L +WQ +
Sbjct: 1586 QSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ 1645
Query: 946 LADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTE 1005
+ K L A QN++ + W+ E + + +++ G DLA V L +K E
Sbjct: 1646 KSAEKSQKLKEANKQQNFNTGIKDFDFWLSE-VEALLASEDYGKDLASVNNLLKKHQLLE 1704
Query: 1006 RDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR 1065
D+ A R+ +L +A++L + + + ++ +++ R L E+
Sbjct: 1705 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1764
Query: 1066 RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR 1125
RL F R +DD ++W+ + V SE+ L + L +H L E+ + +
Sbjct: 1765 RLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL 1824
Query: 1126 ALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAE 1185
G++++ D + ++QRL W+EL ++ +R RL ++ +Q F+ + + E
Sbjct: 1825 DTGKKLSDDNTIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEE 1883
Query: 1186 GVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIH 1245
++ + +++ + TL A +KK E F + + +R++ + G+ L+ + N H
Sbjct: 1884 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1943
Query: 1246 ADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVS 1305
+ I K + + + AA Q +L +N F ++ WI EK + +
Sbjct: 1944 EENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDD 2003
Query: 1306 YD-EARNLHTKWQKHQAFMAELAA-NKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHR 1363
Y + ++ T K + F A L A ++ + + +L K + + L +
Sbjct: 2004 YGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMK 2063
Query: 1364 RWDELETTTQAKARSLFDA----NRAE----LFAQSCCALESWLESLQAQLHSDDYGKDL 1415
RW +L + A+ + L +A + E FA+ A SW E+ + L D
Sbjct: 2064 RWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDL------TDP 2117
Query: 1416 TSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVE--------RTSRAVE 1467
N L + + + E A R + + QA LA+ D+ T A+E
Sbjct: 2118 VRCNSLEEIKALREAHDAFR-SSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALE 2176
Query: 1468 EKFRALCQPMRERCRRLQASREQHQFHRDVEDEIL--------WVTERLPMASSMEHGKD 1519
E +R L + ++ER LQ + + + + + E W+ E
Sbjct: 2177 ETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTY--------- 2227
Query: 1520 LPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELEL 1579
L +++++ TL+ +++ + + ++R A +L +++++
Sbjct: 2228 LLDGSCMVEESGTLESQLEATKRKHQEIR---------AMRSQLKKIEDL---------- 2268
Query: 1580 RGKRLEDALRAQQFYRDAAE---AEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQA 1636
G +E+AL Y + + A+ W +L M Q + ++ A+ V E+A
Sbjct: 2269 -GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQAR---NTTGVTEEA 2324
Query: 1637 LADYAQTIHQLAASSQDMIDHEHPESTRIS-------IRQAQVDKLYAGLKELAGERRE- 1688
L +++ ++H+ +S S + + + D + + + R+
Sbjct: 2325 LKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2384
Query: 1689 --RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRD 1742
LQE++ + RE ++++ E+ +A L + + + ++ +R+
Sbjct: 2385 HVSLQEYMAF-MISRETENVK---SSEEIESAFRALSSEGKPYVTKEELYQNLTRE 2436
Score = 85.5 bits (210), Expect = 6e-16
Identities = 62/225 (27%), Positives = 113/225 (50%), Gaps = 6/225 (2%)
Query: 1873 DKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMD 1931
+ AE+I Q V + + + + S RRQ L D+ +F+FF+ EL W+ E LQ+
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQE-KLQIA 67
Query: 1932 AQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQL 1991
+ E +D ++ ++ Q +AE++A + + G +++ H+A+E I +L +L
Sbjct: 68 SDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMEL 127
Query: 1992 QARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESL 2051
+ + EK +EK L +++ + R+ W+ +E +V S ELG ++ VE L
Sbjct: 128 HRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVL 187
Query: 2052 IKRHEAFQKSAVAWEERFCALEKLTA---LEEREKERKRKREEEE 2093
K+ E FQ A EER + + A E+ +E K +++E
Sbjct: 188 QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDE 232
Score = 56.2 bits (134), Expect = 4e-07
Identities = 60/253 (23%), Positives = 105/253 (41%), Gaps = 19/253 (7%)
Query: 287 AVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQS 346
A K++ + H + E L + AS W E L D NSL ++ ++
Sbjct: 2073 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2132
Query: 347 FNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAE 406
+++R+ + + L L I+S A+N + E + + W L+K
Sbjct: 2133 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKII 2186
Query: 407 HERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-----DNFGLELAAVE 461
EREL L+ E RQE+ ++L F + A W+ E + + + G + +E
Sbjct: 2187 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2246
Query: 462 AAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
A RKH+ +I A +++ ++ + A + D K +A+ WD L Q+
Sbjct: 2247 ATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQL-- 2300
Query: 522 ARRERLLLNLELQ 534
R+ NLE Q
Sbjct: 2301 --GMRMQHNLEQQ 2311
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 558 bits (1439), Expect = e-158
Identities = 447/1782 (25%), Positives = 793/1782 (44%), Gaps = 142/1782 (7%)
Query: 314 ASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ 373
+ EL W+ + + T D + S +Q ++Q ++ +
Sbjct: 582 SDELKSWVNEKMKTATDEAYKDP-SNLQGKVQKHQAF----------------------E 618
Query: 374 SKLRANNQKVYT-PREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAAR--- 429
++L AN ++ + G+ + D+N + A ++L +L+ +L+ + R
Sbjct: 619 AELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN 678
Query: 430 ----FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVD 485
F+R E WL E + ++ D++G +L V+ +KH +E D+ A+ R+ +
Sbjct: 679 QQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGIT 738
Query: 486 AVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD 545
A + + D + I +Q + ++ L++ + AR+++L +L LQ++F+D+
Sbjct: 739 IQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEET 798
Query: 546 WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR 605
W+ E + S + G+ L GV++LL+ H+ ++A+IA R++AV+ G
Sbjct: 799 WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH--- 855
Query: 606 PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665
+ V ++ +L Q +EAL A+ RR LE+S + ++ + EAE+W+RE++ ++
Sbjct: 856 -FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVG 914
Query: 666 SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAA-- 723
S D G+D A LL KH AL ++S ++ EQ Q + P +
Sbjct: 915 STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLA 974
Query: 724 --ELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFS 781
+ Q + R + + L + + ++ + ND + ++ A
Sbjct: 975 LYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY-------------- 1020
Query: 782 TQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARA 841
+ L A E + + ++ +EQ V R+ +E Y L
Sbjct: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
Query: 842 GERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEM 901
+R LE + + + EA W+ EKE L + LE +EV+Q++F+ + ++
Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
Query: 902 NTLAAQITAVNDIAEQLLK-----------------------------ANPPGKDRIV-- 930
+++ +N +AE L A+P R++
Sbjct: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
Query: 931 -----NTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQ 985
N+ ++LN RW+ ++LA+ + L SA +Q +H + ET+ W+ EK + + +T
Sbjct: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL-NTD 1259
Query: 986 GLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQT 1045
G+DLA V ALQRK G ERDL A+ +V L A L HP A + + E+
Sbjct: 1260 NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQ 1319
Query: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105
W L +R+ LG++ LQ FL D +W+ + V+S+E + AEALL
Sbjct: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLE 1379
Query: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRD--QADPQCLFLRQRLEALGTGWEELGRMWES 1163
+H R E++ + G+++ A P+ ++Q+L+ L +L + W
Sbjct: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQKLDILDQERADLEKAWVQ 1436
Query: 1164 RQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDA 1223
R+ L Q Q F RD QAE ++++E L+ + +L + +A IKK EDF ++
Sbjct: 1437 RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINV 1496
Query: 1224 NGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHF 1283
E+I L QL++ G+ I + + + R ++ + + +L +++ Q F
Sbjct: 1497 QEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQF 1556
Query: 1284 LQDCHELKLWIDEKMLTAQDVSYDEARNLH-----TKWQKHQAFMAELAANKDWLDKVDK 1338
+D E++ WI EK+ TA D SY + N+ +K QKHQAF AEL AN D + V
Sbjct: 1557 SRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVID 1616
Query: 1339 EGRELTLEKPELKA---LVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCAL 1395
G L +E+ V +L L +W L + K++ L +AN+ + F
Sbjct: 1617 MGNSL-IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
Query: 1396 ESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ- 1454
+ WL ++A L S+DYGKDL SVN LLKK Q+LE +++ E ++ + +QA +L
Sbjct: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAF 1735
Query: 1455 GAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSM 1514
+V+ + +F+ + R +L S HQF RD++DE W+ E+ + S
Sbjct: 1736 DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSE 1795
Query: 1515 EHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQE 1568
++G+DL VQ L KK++ L+ E+ HEP I + + + L G LA+ E
Sbjct: 1796 DYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVE 1855
Query: 1569 MWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEV 1627
WK L RG+RLE++L QQF + E EAW+ E ++ ++ E D L+A Q +
Sbjct: 1856 HWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLL 1914
Query: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERR 1687
KKH+ E + ++ + + QD+I + IS + ++ + L++ A +R+
Sbjct: 1915 KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRK 1974
Query: 1688 ERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIG 1747
+L E+ Q + D +E WI E+E + + G+D V L K F
Sbjct: 1975 AKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2034
Query: 1748 QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQR-- 1805
QE + + AL + L+A H + SL + W+ LL R + L A R
Sbjct: 2035 QEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKV 2094
Query: 1806 ---FLHGARQALA---RVQHKQQQLPDGTG-RDLNAAEALQRRHCAYEHDIQALSPQVQQ 1858
FL A++A A ++ ++ L D L +AL+ H A+ + + Q
Sbjct: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154
Query: 1859 VQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAAR------RQLLLDTTDKFR- 1911
+ + ++ K++ M+A+ E W LQ R Q + DK R
Sbjct: 2155 LAELDRQI-KSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ 2213
Query: 1912 -FFKAVRELMLWMDEVNLQ-MDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDM 1969
F + W+ E +D + + + ++ + EI A + D+
Sbjct: 2214 EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDL 2273
Query: 1970 G---KELLARSHYAAEEIS-------EKLSQLQARRQETAEK 2001
G +E L + E + ++L QL R Q E+
Sbjct: 2274 GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2315
Score = 521 bits (1341), Expect = e-147
Identities = 384/1412 (27%), Positives = 668/1412 (47%), Gaps = 75/1412 (5%)
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774
A R ++ ++ R + L+ R Q+L + FQ DA ++E W+ + L+ ++S E
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASDE 70
Query: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERH 833
D + Q ++H+A E E++++ + L E + E ++ R+ L R
Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893
+E L + E+ L A L L E W+ +KE + L + LE +EV+Q++
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 894 FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953
FE + +M ++ VN A +L++ P ++ I Q+++N WQ+ + LA ++
Sbjct: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
Query: 954 LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013
L A +Q ++ + ET +W++EK +++ S G DLA V AL RK G ERDL A+
Sbjct: 251 LFGAAEVQRFNRDVDETISWIKEKEQLMASDD-FGRDLASVQALLRKHEGLERDLAALED 309
Query: 1014 RVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRS 1073
+V L EA+ L HP A I + E+ T WE +R R L ++ RLQ FL
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 1074 LDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR 1133
D +W+ + + ++E + + AEALL +H +GE++ + + G+ +
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 1134 --DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQ 1191
A + +R++L L L +WE R+ + Q Q F RD Q + +S Q
Sbjct: 430 AGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
Query: 1192 EYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
E L + ++ +L + +A +KK EDF ++ A E+I L E +L+ + + +
Sbjct: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARN 1311
+ D++ R + A + +L D+ Q F +D ELK W++EKM TA D +Y + N
Sbjct: 547 RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
Query: 1312 LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETT 1371
L K QKHQAF AEL+AN+ +D ++K G++L K V+ ++ ++ W +L
Sbjct: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWE 1431
T+ K L +AN+ + F ++ +E WL ++ L SDDYGKDLT+V L KK +LE +
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
Query: 1432 MAVREKEVEAIQAQAKALAQEDQG---AGEVERTSRAVEEKFRALCQPMRERCRRLQASR 1488
+A + ++ I QA+ +D G A +++ A+ ++ AL +PM R ++L S
Sbjct: 727 VAAHQDRIDGITIQARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
Query: 1489 EQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR 1548
Q RDVEDE W+ E+ P+A+S GKDL VQ L+KK+Q LQ EI GHEPRI +
Sbjct: 785 RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT 844
Query: 1549 ERQRAL------GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEA 1602
++ A+ A +L EL + W+ L + R + LED+L+AQQ++ DA EAE+
Sbjct: 845 QKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
Query: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-- 1660
WM E+E + + KDE SA+A +KKH+ L L+ Y +I L +Q P
Sbjct: 905 WMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRE--RLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
+ T + A D +E+ ++ + L + E++D + ++ V
Sbjct: 965 DETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV--K 1022
Query: 1719 SHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDS 1778
+ Q +L + + + + QE++D+ + AG + R E
Sbjct: 1023 KLDPAQSASRENLLEE------QGSIALRQEQIDNQTRITKE--AGSVSLRMKQVE---- 1070
Query: 1779 LNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEA 1837
E + LLEL + R +L + + A + + K+ L + G DL E
Sbjct: 1071 --ELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 1838 LQRRHCAYEHDIQA-------LSPQVQQVQDDGHRLQKAYAGDKAEEIG----------- 1879
LQ++ ++ D++A ++ + ++ +G ++ A + E G
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 1880 -----------------RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLW 1922
++ + E W LQ + R QLL + RF + E W
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
Query: 1923 MDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAE 1982
++E N ++ D++S + + +G + ++ A D+ +S + + L+ +AE
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308
Query: 1983 EISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELG 2042
++ EK ++L ++ ++ L ++ F D +W+ LV S EL
Sbjct: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
Query: 2043 CTVDEVESLIKRHEAFQKSAVAWEERFCALEK 2074
V E+L++RH+ + A F A E+
Sbjct: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Score = 499 bits (1284), Expect = e-140
Identities = 394/1525 (25%), Positives = 705/1525 (46%), Gaps = 97/1525 (6%)
Query: 612 VSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR 671
+ ER ++ Y EL+ RR +LE+S R F + E E W++E+ + AS + +
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI-ASDENYK 73
Query: 672 DLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWER 731
D T L KH A E+ G + E G +++EGH + R EL QWE
Sbjct: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
Query: 732 LEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRA 791
L E+ +L QA L Q+ + D+ W+ D +V+S ELG D + L ++
Sbjct: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 792 LEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERHYEELQARAGERARALEA 850
+ ++ +H ++ + + AA L E ++ + + ++ L+ A +R L
Sbjct: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
Query: 851 ALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITA 910
A + + W++EKEQ + L ++ + ++ E LE ++ L ++ A
Sbjct: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
Query: 911 VNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTET 970
+ A++L +++P +I +E+L W+Q R LA + A L + +Q + + +
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
Query: 971 QAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL-AAGH 1029
+W+ E +I + + L +D+AG AL + + +++A AL AAGH
Sbjct: 374 TSWVTEMKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRR----REESLGEARRLQDFLRSLDDFQAWLGRTQ 1085
A + +RE T + RA + R + + LQ F R + W+ + +
Sbjct: 433 YA-----SDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF--L 1143
+ +E+ +L EALL +H + AQ E ++ AL E T+ + +
Sbjct: 488 AFLLNEDLGDSLDSVEALLKKHEDFEKSLS-AQEE--KITALDEFATKLIQNNHYAMEDV 544
Query: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM--P 1201
R +AL + L R+ +LA + Q F RD+ + + ++ + + P
Sbjct: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP 604
Query: 1202 GTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHK 1261
LQ ++K + F + + AN RI L +AG++L+ + D++ + + + K
Sbjct: 605 SNLQGK---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWK 661
Query: 1262 KNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKM--LTAQDVSYDEARNLHTKWQKH 1319
K +A + +LR+ +QQ F ++ +++LW+ E L + D D N+ +KH
Sbjct: 662 KLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKH 720
Query: 1320 QAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
A++AA++D +D + + R+ + +K L R++ L+ A+ + L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D+ R + + E+W+ + S + GKDL V LLKK Q L+ E+A E +
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 1440 EAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVE 1498
+A+ + A+ +E A E V+ + +K+ AL +R + L+ S + Q+ D
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 1499 DEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAA 1558
+ W+ E+ P+ S ++GKD S + L+KK++ L ++ + I LRE+ ++
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
Query: 1559 AGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAK 1618
A + G EL L A Y++ + E M + ++ + K
Sbjct: 961 APTD--------DETGKELVL----------ALYDYQEKSPREVTMKKGDILTLLNSTNK 1002
Query: 1619 DELSAQ----------AEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEH---PESTRI 1665
D + A VKK + A + A Q+ ID++ E+ +
Sbjct: 1003 DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSV 1062
Query: 1666 SIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQD 1725
S+R QV++LY L EL +R+ L++ + L RE ++L+QWI E+E S E+G D
Sbjct: 1063 SLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGAD 1122
Query: 1726 YEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA--------------- 1770
E V +L+ KF +F +D + R+ N +A L + G A
Sbjct: 1123 LEQVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPR 1181
Query: 1771 ------TVAEWKDS---------------LNEAWADLLELLDTRGQVLAAAYELQRFLHG 1809
T + WK + LNE W L +L + R Q+L +A+E+QRF
Sbjct: 1182 DETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRD 1241
Query: 1810 ARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK 1868
A + ++ K Q L D G DL + +ALQR+H +E D+ AL +V + + RL +
Sbjct: 1242 ADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQ 1301
Query: 1869 AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNL 1928
++ + AE++ + +AW+ L + R+ L D+ D RF R+LM W++ +
Sbjct: 1302 SHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRG 1360
Query: 1929 QMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKL 1988
+ + E +DV+ A+ +++ Q + EI+ARA F + G++LLA HYA+ EI +KL
Sbjct: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
Query: 1989 SQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEV 2048
L R + + W ++ L LE+ +F RD AE W+ ++E + + + G ++D V
Sbjct: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
Query: 2049 ESLIKRHEAFQKSAVAWEERFCALE 2073
E+LIK+HE F K+ EE+ AL+
Sbjct: 1481 EALIKKHEDFDKAINVQEEKIAALQ 1505
Score = 446 bits (1146), Expect = e-124
Identities = 399/1724 (23%), Positives = 756/1724 (43%), Gaps = 113/1724 (6%)
Query: 418 IRQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIV 475
+R++KLE F R A E W+ E ++ S +N+ + ++ ++KH+A E ++
Sbjct: 35 LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
Query: 476 AYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQK 535
A SG + +D + +E + + I R + R W+ L + + + +LL +L +
Sbjct: 94 ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
Query: 536 VFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASAL 595
++ +MDW+ + + + S++LG+ L VE L + E + D+A ERV V+ A
Sbjct: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
Query: 596 RFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEA 655
+ +E P + +L+ + ++ +++ L LA R+ +L + + RF +V E +
Sbjct: 214 KLI---QEQHP-EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
Query: 656 WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHP-G 714
W++E++ L+AS D GRDL LL KH L +++ +K + +L + HP
Sbjct: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL-QQSHPLS 328
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774
A+Q + EL WE++ LA ER RL + L +F AD D+ +W+ + L+++ E
Sbjct: 329 ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
Query: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQA-AALPPTLSRTPEVQGRVPTLERH 833
L D +AL +H+ + EI +H + + E A L + EV+ ++ L
Sbjct: 389 LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEE 448
Query: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893
L R + E + L + W+ ++E +L L + L+ +E + ++
Sbjct: 449 RAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKK 508
Query: 894 FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953
E E ++ +ITA+++ A +L++ N + + ++ L R A ++A
Sbjct: 509 HEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQ 568
Query: 954 LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013
L + +Q + + E ++W+ EK K +T D + + +K E +L A +
Sbjct: 569 LADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQS 626
Query: 1014 RVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRS 1073
R+ L + L + + AR+ EV + W+ L + L EA + Q F R+
Sbjct: 627 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN 686
Query: 1074 LDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR 1133
++D + WL + +AS++ L + L +HA L +V Q + + +
Sbjct: 687 VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF-Q 745
Query: 1134 DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEY 1193
D ++++ EAL +E L +R+ +LA + Q RD E + +E
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
Query: 1194 VLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKA 1253
+ + T L +KK + + + + RI + + G +V EG+ A+ ++ K
Sbjct: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
Query: 1254 DSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEK--MLTAQDVSYDEARN 1311
+ ++ + + A Q L D+ + Q + D +E + W+ EK ++ + D DE +
Sbjct: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDE-DS 924
Query: 1312 LHTKWQKHQAFMAELAANKDWLDKV---------------DKEGRELTLEKPELKALVSE 1356
+KH+A M++L+A + + D+ G+EL L
Sbjct: 925 AEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVL----------- 973
Query: 1357 KLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
L D + T + +L ++ + + + ++ + A + D + +
Sbjct: 974 ALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA--AYVKKLDPAQSAS 1031
Query: 1417 SVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQP 1476
N+L + + +A+R+++++ K AG V + VEE + +L +
Sbjct: 1032 RENLLEE-----QGSIALRQEQIDNQTRITKE-------AGSVSLRMKQVEELYHSLLEL 1079
Query: 1477 MRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKE 1536
+R L+ S ++ R+ + W+ E+ +S E G DL V++L KK QK+
Sbjct: 1080 GEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139
Query: 1537 IQGHEPRIADLR-------------------ERQRALG--------AAAAGP-------- 1561
++ +E R+ D+ ++Q G + A P
Sbjct: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
Query: 1562 -------ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQ 1614
+ EL E W+ L E R + L A Q+F+RDA E + W+ E+ +
Sbjct: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
Query: 1615 EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTR-ISIRQAQVD 1673
D S QA +KH+ E+ LA ++ L +++ +I HPES + + +++
Sbjct: 1260 NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELN 1318
Query: 1674 KLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLR 1733
+ ++ L + A +R+ +L + L + + DL WI + +S EL +D L
Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
Query: 1734 DKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
++ +E R + L+A GH A + + D L++ ADL + R
Sbjct: 1379 ERHQE-HRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437
Query: 1794 GQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQAL 1852
+L ELQ F QA + ++ L + G L++ EAL ++H ++ I
Sbjct: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497
Query: 1853 SPQVQQVQDDGHRLQKAYAGDKAE-EIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFR 1911
++ +Q +L AG A+ +I V + W +L+ +R L ++ +
Sbjct: 1498 EEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555
Query: 1912 FFKAVRELMLWMDEVNLQMDAQER---PRDVSSADLVIKNQ--QGIKAEIEARADRFSSC 1966
F + V E+ W+ E LQ + E P ++ + L+ K+Q Q +AE+ A ADR
Sbjct: 1556 FSRDVDEIEAWISE-KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGV 1614
Query: 1967 IDMGKELLARSHYAAEE--ISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGM 2024
IDMG L+ R A E + +L+ L + Q +K EK L+ + F
Sbjct: 1615 IDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKD 1674
Query: 2025 AEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEER 2068
+ WL E L+ S + G + V +L+K+H+ + A E+R
Sbjct: 1675 FDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718
Score = 437 bits (1123), Expect = e-122
Identities = 421/1888 (22%), Positives = 807/1888 (42%), Gaps = 121/1888 (6%)
Query: 259 VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318
+ P+E+ I T + ++K LA++ R GK+ A V+++ E +
Sbjct: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAAE-----VQRFNRDVDETI 268
Query: 319 QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378
WI++ + L+ VQ L+ LE L ++ K++A
Sbjct: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHEG---------------LERDLAALEDKVKA 313
Query: 379 NNQKVYTPREGRLIS---------DINKAWERLEKAEHERELALRTELIRQEKLEQLAAR 429
+ ++ +S ++ WE++ ER L +L++ A
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY----RLQRFLAD 369
Query: 430 FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAA 489
F + W++E + L++ D ++A EA + +H+ + +I A+ ++ D
Sbjct: 370 FRDLTS----WVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
Query: 490 ELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEE 549
L A ++ + + ++ L ++ RR++ ++LQ ++D + +WM +
Sbjct: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
Query: 550 MKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDP 609
+ L ++DLG L VE LL+ HE E ++ Q E++ A+ A + Y D
Sbjct: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ-NNHYAMED- 543
Query: 610 QLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADT 669
V+ R L AL E A RRA+L +S L +F + E ++WV E+ A+ +
Sbjct: 544 --VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT-ATDEA 600
Query: 670 GRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW 729
+D + + KH A E+S + + GQ+L+ H + +AR E+ + W
Sbjct: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 730 ERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQH 789
++L E + +L +A QF + D+E WL + ++S + G D + Q L ++H
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 790 RALEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERHYEELQARAGERARAL 848
LE ++ +H+ +D + QA E ++ + L YE L+ R + L
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
+L L + + W+ EKE + L ++ + ++ + L+ E+ +I
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
AV +++ + + +LN +W+ + A ++ L +L Q Y +
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E ++WMREK ++ ST G D AL +K DL A + + L +A +
Sbjct: 901 EAESWMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-- 957
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ-DFLRSLDDFQAWLGRTQTA 1087
Q VA + +TG E + A +E+S E + D L L+ + +
Sbjct: 958 ---QQVAPT----DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-- 1008
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQR- 1146
V +G + L +A R + Q + + + TR + + LR +
Sbjct: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ 1068
Query: 1147 LEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQA 1206
+E L ELG E R+G L ++ R+A + + ++ +E L+ E+ L+
Sbjct: 1069 VEELYHSLLELG---EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQ 1125
Query: 1207 ADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG------------NIHADKIREKAD 1254
+ KK +DF + AN R+ + + L SEG ++ R++ D
Sbjct: 1126 VEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETD 1185
Query: 1255 S------------------------IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHEL 1290
S + R + Q A++ L E Q F +D E
Sbjct: 1186 SKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADET 1245
Query: 1291 KLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP 1348
K WI+EK L + +D A ++ +KH+ F +LAA D ++ + + L P
Sbjct: 1246 KEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP 1304
Query: 1349 ELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS 1408
E + EK +L++ W L + L D++ + F L SW+ ++ + S
Sbjct: 1305 ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSS 1364
Query: 1409 DDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAI-QAQAKALAQEDQGAGEVERTSRAVE 1467
D+ KD+T LL++ Q E+ R +A Q + LA + E+++ ++
Sbjct: 1365 DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILD 1424
Query: 1468 EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLM 1527
++ L + +R L E FHRD E W+ R ++ + G L SV+ L+
Sbjct: 1425 QERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALI 1484
Query: 1528 KKNQTLQKEIQGHEPRIADLR---ERQRALGAAAAGPELA---ELQEMWKRLGHELELRG 1581
KK++ K I E +IA L+ ++ A G A G + E+ + W+RL ++ +
Sbjct: 1485 KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKR 1544
Query: 1582 KRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQ-----AEVKKHQVLEQA 1636
+L ++ QQF RD E EAW+ E+ L E KD + Q ++ +KHQ E
Sbjct: 1545 SKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAE 1603
Query: 1637 LADYAQTIHQLAASSQDMIDHEHPESTR--ISIRQAQVDKLYAGLKELAGERRERLQEHL 1694
L A I + +I+ + + R A + + L + + E+ ++L+E
Sbjct: 1604 LHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
Query: 1695 RLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSA 1754
+ + D + W+ E E + AS + G+D V L K + D S ++R+
Sbjct: 1664 KQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISA-HEDRLKDL 1722
Query: 1755 NALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQAL 1814
N+ A+ L+ + V + +D++N + + + +R L ++ L +F
Sbjct: 1723 NSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEE 1782
Query: 1815 ARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
+ ++ K+ + + GRDL + L+++H E ++ A P +Q V D G +L
Sbjct: 1783 SWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIG 1842
Query: 1874 KAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ 1933
K EEI + + E W +L+ +AAR Q L ++ + +F V E W++E + ++
Sbjct: 1843 K-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASE 1901
Query: 1934 ERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQA 1993
+ +++ ++K + + + DR + G++L+ ++++ E IS K+ L
Sbjct: 1902 DYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNG 1961
Query: 1994 RRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIK 2053
+ + + ++ L L F A + E+W+ +E +++ + G + V++L+
Sbjct: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
Query: 2054 RHEAFQKSAVAWEERFCALEKLTALEER 2081
+ E F A+++ + +TAL+++
Sbjct: 2022 KQETFDAGLQAFQQE--GIANITALKDQ 2047
Score = 318 bits (814), Expect = 5e-86
Identities = 277/1205 (22%), Positives = 530/1205 (43%), Gaps = 43/1205 (3%)
Query: 929 IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988
I ++Q+ R+ +F+ L+ ++ L + Q + + E + W++EK ++
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
Query: 989 NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048
D + +K E +++A + + +L N + + + I RL E+ WE
Sbjct: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
Query: 1049 DLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108
L MR + L +A++L +LR +D W+ + V SEE L E L +
Sbjct: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 192
Query: 1109 ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
+ ++ + + + ++ ++Q P+ ++ + + + W+ L + RQG+L
Sbjct: 193 EFQTDMAAHEERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
Query: 1169 AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228
A Q F RD + + +E +++ + L + A ++K E + A +++
Sbjct: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKV 311
Query: 1229 HGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCH 1288
L +L + A +I+ K + + ++ + A + RL D+ Q FL D
Sbjct: 312 KALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR 371
Query: 1289 ELKLWIDE-KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK 1347
+L W+ E K L D + +HQ E+ A++D D+ G+ L
Sbjct: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAG 431
Query: 1348 PELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLH 1407
V EKL L L + + + +LF + +++W+ +A L
Sbjct: 432 HYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLL 491
Query: 1408 SDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSR-AV 1466
++D G L SV LLKK + E ++ +E+++ A+ A L Q + A E T R A+
Sbjct: 492 NEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDAL 551
Query: 1467 EEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
+ AL + R +L S QF RD ++ WV E++ A+ E KD ++Q
Sbjct: 552 LSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSNLQGK 610
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQEMWKRLGHELELR 1580
++K+Q + E+ ++ RI L + + L + E+ +WK+L EL+
Sbjct: 611 VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELK 670
Query: 1581 GKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
G +L +A + QQF R+ + E W+ E E H+ + KD + Q KKH +LE +A +
Sbjct: 671 GIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAH 730
Query: 1641 AQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLR 1700
I + ++ D H ++ I +Q + Y LKE R+++L + LRL QL
Sbjct: 731 QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLF 790
Query: 1701 RELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQE-RVDSANALAN 1759
R+++D E WI+E+E +AAS G+D V L K + + + G E R+ + N
Sbjct: 791 RDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA--GHEPRIKAVTQKGN 848
Query: 1760 GLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQH 1819
++ GH A V LN+ W L R Q L + + Q++ A +A + ++
Sbjct: 849 AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
Query: 1820 KQQQLPDGT-GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEI 1878
K+ + G+D ++AEAL ++H A D+ A +Q +++ ++ A +E
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD-DET 967
Query: 1879 GRHMQAVAEAWAQLQGSSAARRQ----LLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQE 1934
G+ + + + ++ LL++T+K + V + ++ ++ +
Sbjct: 968 GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK---KL 1024
Query: 1935 RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQAR 1994
P +S + +++ Q I R ++ + + KE A +S ++ Q++
Sbjct: 1025 DPAQSASRENLLEEQ----GSIALRQEQIDNQTRITKE--------AGSVSLRMKQVEEL 1072
Query: 1995 RQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKR 2054
E +++ L+ + + R+A + W+ +E + S E+G +++VE L K+
Sbjct: 1073 YHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKK 1132
Query: 2055 HEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVG 2114
+ FQK A E R + K+ E+ E E E + ++Q + P D
Sbjct: 1133 FDDFQKDLKANESRLKDINKVA--EDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETD 1185
Query: 2115 GQTAS 2119
+TAS
Sbjct: 1186 SKTAS 1190
Score = 277 bits (708), Expect = 1e-73
Identities = 296/1437 (20%), Positives = 593/1437 (41%), Gaps = 133/1437 (9%)
Query: 390 RLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFD--RKAAMRETWLSENQRL 447
R+ + R+++ E L R+ LE+ +F R+A + W++E +
Sbjct: 1054 RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
Query: 448 VSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
++ + G +L VE +K + + D+ A R++ ++ VA +L +E + A +Q
Sbjct: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
Query: 508 NV-------------------ARL-----------------WDFLRQMVAARRERLLLNL 531
V ARL W L+Q+ R + L
Sbjct: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
Query: 532 ELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVS 591
E+Q+ +D +W+EE L + + G LA V+ L + HE E D+A ++V ++
Sbjct: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
Query: 592 ASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVG 651
+A R + P + + E+ +L Q++ +L + A R+A+L +S L RFL +
Sbjct: 1294 ETAERLI----QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFR 1349
Query: 652 EAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEG 711
+ +W+ + L++S + +D+TGA LL +H R E+ R G + + GQQL+A G
Sbjct: 1350 DLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHG 1409
Query: 712 HPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVS 771
H + + + L + LE +R L Q L F D E W+ ++
Sbjct: 1410 HYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLN 1469
Query: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTP-EVQGRVPTL 830
+ + G S +AL ++H ++ I + AL+ A L ++ R +
Sbjct: 1470 TEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEV 1529
Query: 831 ERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPE----RLED 886
+ L+A+ E+ L + L + W+ EK Q + + + +L
Sbjct: 1530 LDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSK 1589
Query: 887 LEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK--ANPPGKDRIVNTQEQLNHRWQQFR 944
L Q+ + E E++ A +I V D+ L++ A +D + L +WQ
Sbjct: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLV 1649
Query: 945 RLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT 1004
+ + K L A QN++ + W+ E + + +++ G DLA V L +K
Sbjct: 1650 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSE-VEALLASEDYGKDLASVNNLLKKHQLL 1708
Query: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064
E D+ A R+ +L +A++L + + + ++ +++ R L E+
Sbjct: 1709 EADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNES 1768
Query: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL 1124
RL F R +DD ++W+ + V SE+ L + L +H L E+ + +
Sbjct: 1769 HRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1828
Query: 1125 RALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA 1184
G++++ D + ++QRL W+EL ++ +R RL ++ +Q F+ + +
Sbjct: 1829 LDTGKKLSDDNTIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
Query: 1185 EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNI 1244
E ++ + +++ + TL A +KK E F + + +R++ + G+ L+ + N
Sbjct: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH 1947
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDV 1304
H + I K + + + AA Q +L +N F ++ WI EK + +
Sbjct: 1948 HEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTD 2007
Query: 1305 SYD-EARNLHTKWQKHQAFMAELAA-NKDWLDKVDKEGRELTLEKPELKALVSEKLRDLH 1362
Y + ++ T K + F A L A ++ + + +L K + + L
Sbjct: 2008 DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLM 2067
Query: 1363 RRWDELETTTQAKARSLFDA----NRAE----LFAQSCCALESWLESLQAQLHSDDYGKD 1414
+RW +L + A+ + L +A + E FA+ A SW E+ + L D
Sbjct: 2068 KRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDL------TD 2121
Query: 1415 LTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVE--------RTSRAV 1466
N L + + + E A R + + QA LA+ D+ T A+
Sbjct: 2122 PVRCNSLEEIKALREAHDAFR-SSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEAL 2180
Query: 1467 EEKFRALCQPMRERCRRLQASREQHQFHRDVEDEIL--------WVTERLPMASSMEHGK 1518
EE +R L + ++ER LQ + + + + + E W+ E
Sbjct: 2181 EETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTY-------- 2232
Query: 1519 DLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELE 1578
L +++++ TL+ +++ + + ++R A +L +++++
Sbjct: 2233 -LLDGSCMVEESGTLESQLEATKRKHQEIR---------AMRSQLKKIEDL--------- 2273
Query: 1579 LRGKRLEDALRAQQFYRDAAE---AEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQ 1635
G +E+AL Y + + A+ W +L M Q + ++ A+ V E+
Sbjct: 2274 --GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQAR---NTTGVTEE 2328
Query: 1636 ALADYAQTIHQLAASSQDMIDHEHPESTRIS-------IRQAQVDKLYAGLKELAGERRE 1688
AL +++ ++H+ +S S + + + D + + + R+
Sbjct: 2329 ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRD 2388
Query: 1689 ---RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRD 1742
LQE++ + RE ++++ E+ +A L + + + ++ +R+
Sbjct: 2389 GHVSLQEYMAF-MISRETENVK---SSEEIESAFRALSSEGKPYVTKEELYQNLTRE 2441
Score = 85.5 bits (210), Expect = 6e-16
Identities = 62/225 (27%), Positives = 113/225 (50%), Gaps = 6/225 (2%)
Query: 1873 DKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMD 1931
+ AE+I Q V + + + + S RRQ L D+ +F+FF+ EL W+ E LQ+
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQE-KLQIA 67
Query: 1932 AQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQL 1991
+ E +D ++ ++ Q +AE++A + + G +++ H+A+E I +L +L
Sbjct: 68 SDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMEL 127
Query: 1992 QARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESL 2051
+ + EK +EK L +++ + R+ W+ +E +V S ELG ++ VE L
Sbjct: 128 HRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVL 187
Query: 2052 IKRHEAFQKSAVAWEERFCALEKLTA---LEEREKERKRKREEEE 2093
K+ E FQ A EER + + A E+ +E K +++E
Sbjct: 188 QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDE 232
Score = 56.2 bits (134), Expect = 4e-07
Identities = 60/253 (23%), Positives = 105/253 (41%), Gaps = 19/253 (7%)
Query: 287 AVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQS 346
A K++ + H + E L + AS W E L D NSL ++ ++
Sbjct: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137
Query: 347 FNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAE 406
+++R+ + + L L I+S A+N + E + + W L+K
Sbjct: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKII 2191
Query: 407 HERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-----DNFGLELAAVE 461
EREL L+ E RQE+ ++L F + A W+ E + + + G + +E
Sbjct: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251
Query: 462 AAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
A RKH+ +I A +++ ++ + A + D K +A+ WD L Q+
Sbjct: 2252 ATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQL-- 2305
Query: 522 ARRERLLLNLELQ 534
R+ NLE Q
Sbjct: 2306 --GMRMQHNLEQQ 2316
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo
sapiens]
Length = 678
Score = 531 bits (1367), Expect = e-150
Identities = 290/653 (44%), Positives = 414/653 (63%), Gaps = 10/653 (1%)
Query: 1298 MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK 1357
ML A+D + ++ LH +W +HQAFMAELA NK+WL+K+++EG++L EKPEL A V +K
Sbjct: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
Query: 1358 LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTS 1417
L ++ + W ELE+TTQAKAR LF+A++A+ QS L+ L +++QL D G DL +
Sbjct: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
Query: 1418 VNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPM 1477
VN LKK Q +E ++ +EV +QAQ AL E V AV E+ L +P+
Sbjct: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
Query: 1478 RERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI 1537
+ER R L AS+E HQ D++DE+ WV ERLP+A E G L +VQ +KKNQ L++EI
Sbjct: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
Query: 1538 QGHEPRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDALRA 1590
Q H PR+ ++ ER AL A+ PE L +LQ W L E R + L+ A +
Sbjct: 241 QAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299
Query: 1591 QQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAAS 1650
+Q+Y D AE EAW+GEQEL MM ++K KDE S +KKH LEQ + +Y ++I QL+
Sbjct: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359
Query: 1651 SQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
+ +++ HP+S +IS RQ+QVD+LY LKEL ERR L++ L QL R++ +LE WI
Sbjct: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419
Query: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
E+EVVA S ELGQD+EHV++L++KF EF+ +T G+ER+ + N + + LI GH A A
Sbjct: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479
Query: 1771 TVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGT-- 1828
T+AEWKD LNEAWA+LLEL+ TR Q+LAA+ EL +F AR+ +++ K+++LP T
Sbjct: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539
Query: 1829 GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEA 1888
+A ++QR A+EHD+Q L QV+Q+Q+ +L+ YAG+ AE I Q V +
Sbjct: 540 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599
Query: 1889 WAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSS 1941
W +L + R + T D RF VR+L+ WMD + Q+ A ++PR SS
Sbjct: 600 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSS 652
Score = 151 bits (381), Expect = 8e-36
Identities = 136/593 (22%), Positives = 254/593 (42%), Gaps = 29/593 (4%)
Query: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
+ +I + W LE + L E + ++L Q A D+K E+ L +
Sbjct: 61 LGEIRQCWAELESTTQAKARQL-FEASKADQLVQSFAELDKKLLHMESQLQDVDP----- 114
Query: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
G +LA V + ++K +++E+ + + V + A A L E + + RQ+ V
Sbjct: 115 --GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK-ELVGERQNAVGE 171
Query: 512 LWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQ 571
L + + RR LL + EL +V DL + W++E + G L V+ ++
Sbjct: 172 RLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIK 231
Query: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
++ + +I R+ V A + R + + V + +L+ ++ L E A
Sbjct: 232 KNQGLRREIQAHGPRLEEVLERAGALAS----LRSPEAEAVRRGLEQLQSAWAGLREAAE 287
Query: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
R+ L+ + ++ ++ ++V E EAW+ EQ+ L+ S D G+D L+LL KH L +
Sbjct: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347
Query: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
+ Q + L+ GHP + Q S R +++ + L+ L EER L Q LYQ
Sbjct: 348 NYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ 407
Query: 752 FQADANDMEAWLVDALRLVSSPELGHD--------EFSTQALARQHRALEEEIRSHRPTL 803
+++E W+ + + SPELG D E ++ + A E + + +
Sbjct: 408 LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467
Query: 804 DALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGA 863
D L E T++ + L + EL G RA+ L A+ L+ S+A
Sbjct: 468 DELIECGHTAAATMAEWKD------GLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521
Query: 864 CGLWVEEKEQWLNGLAL-PERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKAN 922
+EEK + L L PE +Q+ E ++ L +Q+ + + A QL
Sbjct: 522 LQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVY 581
Query: 923 P-PGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWM 974
+ I + ++++ W++ + + ++S +H + + +WM
Sbjct: 582 AGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWM 634
Score = 125 bits (315), Expect = 4e-28
Identities = 132/623 (21%), Positives = 248/623 (39%), Gaps = 17/623 (2%)
Query: 682 KHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQ 741
+H A E++ L+ +GQQL+ E A+ + E++ W LE+ + +A+
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 742 RLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRP 801
+L +A+ Q +++ L+ + + G D + + ++ +++E ++
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 802 TLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861
+ L+ Q AALP + V R + L ER R L A+ L+ + +
Sbjct: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL 200
Query: 862 GACGLWVEEKEQWLNGLALPERLEDLEVVQQRF---ETLEPEMNTLAAQITAVNDIAEQL 918
WV+E+ L ER L+ VQQ + L E+ ++ V + A L
Sbjct: 201 DDELAWVQER---LPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 257
Query: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978
P + + EQL W R A+ ++ L +A ++ Y+ + E +AW+ E+
Sbjct: 258 ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQ- 316
Query: 979 KVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANA-LAAGHPAQAVAIN 1037
+++ ++ G D L L +K E+ +E + +L+R+ A L GHP + I+
Sbjct: 317 ELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQIS 375
Query: 1038 ARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATL 1097
R +V + L+ R +L + L R + + + W+ + S E
Sbjct: 376 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 435
Query: 1098 PEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR--DQADPQCLFLRQRLEALGTGWE 1155
L + + E A E RL A+ + V + + + + L W
Sbjct: 436 EHVSVLQEKFSEFASETGMAGRE--RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWA 493
Query: 1156 ELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSH-TEMPGTLQAADAAIKKL 1214
EL + +R LA + F DAR+ +G + + L T P +A + + L
Sbjct: 494 ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL 553
Query: 1215 EDFMSTMDANGERIHGLLEAGRQL--VSEGNIHADKIREKADSIERRHKKNQDAAQQFLG 1272
F + ++ L E QL V G HA+ I + + + K+ A +
Sbjct: 554 RAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE-HAEAIASREQEVLQGWKELLSACEDARL 612
Query: 1273 RLRDNREQQHFLQDCHELKLWID 1295
+ + F +L W+D
Sbjct: 613 HVSSTADALRFHSQVRDLLSWMD 635
Score = 108 bits (269), Expect = 8e-23
Identities = 135/640 (21%), Positives = 269/640 (42%), Gaps = 32/640 (5%)
Query: 788 QHRALEEEIRSHRPTLDALREQAAALPPTLSRTPE----VQGRVPTLERHYEELQARAGE 843
+H+A E+ ++ L+ + + L + PE V+ ++ + + + EL++
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQL---MQEKPELAASVRKKLGEIRQCWAELESTTQA 77
Query: 844 RARAL-EAALA--LYTMLSEAGACGLWVEEKEQWLNG----LALPERLEDLEVVQQRFET 896
+AR L EA+ A L +E L +E + Q ++ + +L+ L+ ++ + E
Sbjct: 78 KARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEE 137
Query: 897 LEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS 956
E+ L AQ A L P K+ + Q + R + ++ L +
Sbjct: 138 WYREVGELQAQTAA--------LPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLA 189
Query: 957 ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVG 1016
+ + + + AW++E+ + T+ GN L V +K G R+++A R+
Sbjct: 190 SKELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRLE 248
Query: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDD 1076
E+ A ALA+ +A A+ L ++Q+ W LR RR++ L A +++ + + +
Sbjct: 249 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 308
Query: 1077 FQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL-RALGEEVTRDQ 1135
+AWLG + + SE+ LL +H L VE + ++L R +
Sbjct: 309 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 368
Query: 1136 ADPQCLFLRQ-RLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYV 1194
D + + RQ +++ L +ELG E R+ L Q + R + E ++ +E V
Sbjct: 369 PDSEQISRRQSQVDRLYVALKELG---EERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
Query: 1195 LSHTEMPGTLQAADAAIKKLEDFMS-TMDANGERIHGLLEAGRQLVSEGNIHADKIREKA 1253
E+ + +K +F S T A ER+ + + +L+ G+ A + E
Sbjct: 426 AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485
Query: 1254 DSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSY-DEARNL 1312
D + + + L +RE F D EL+ I+EK ++ E R
Sbjct: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS 545
Query: 1313 HTKWQKH-QAFMAELAANKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELET 1370
+ Q+ +AF +L + ++ + +L T+ E ++ + +++ + W EL +
Sbjct: 546 ASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLS 605
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDD 1410
+ + A F L SW++ + +Q+ + D
Sbjct: 606 ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
Score = 104 bits (259), Expect = 1e-21
Identities = 144/648 (22%), Positives = 251/648 (38%), Gaps = 73/648 (11%)
Query: 614 ERVAKLEQSYEALC----ELAAARRARLEESRRLW-----------RFLWEVGEAEAWVR 658
E + K+E+ + L ELAA+ R +L E R+ W R L+E +A+ V+
Sbjct: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93
Query: 659 EQQHL----------LASADTGRDLTGALRLLNKHTALR----------GEMSGRLGPLK 698
L L D G DL L K ++ GE+ + L
Sbjct: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 153
Query: 699 LTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADAND 758
L ++LV E + R LE L +ER + L + L+Q D +D
Sbjct: 154 LE-PASKELVGERQNAVGERLVRL---------LEPL-QERRRLLLASKELHQVAHDLDD 202
Query: 759 MEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLS 818
AW+ + L L E G+ + Q ++++ L EI++H P L+ + E+A AL
Sbjct: 203 ELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL-- 260
Query: 819 RTPE---VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWL 875
R+PE V+ + L+ + L+ A R + L+AA + + W+ E+E +
Sbjct: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320
Query: 876 NGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQ 935
+ + + ++ LE + I ++ LL+ P ++I Q Q
Sbjct: 321 MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
Query: 936 LNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVL 995
++ + + L + ++ AL + + +E + W+ EK +V+ + LG D V
Sbjct: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK-EVVAGSPELGQDFEHVS 439
Query: 996 ALQRK---------LAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTG 1046
LQ K +AG ER L A+ V EL + GH A A + +
Sbjct: 440 VLQEKFSEFASETGMAGRER-LAAVNQMVDEL------IECGHTAAATMAEWK-DGLNEA 491
Query: 1047 WEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS-EEGPATLPEAEALLA 1105
W +L M R + L +R L F + Q + + + P P A ++
Sbjct: 492 WAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQR 551
Query: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQ 1165
A +++ S+ +L+ ++ A + R + + GW+EL E +
Sbjct: 552 TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDAR 611
Query: 1166 ---GRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAA 1210
A A F +RD ++SQ P +L A+
Sbjct: 612 LHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPAS 659
Score = 99.0 bits (245), Expect = 5e-20
Identities = 94/449 (20%), Positives = 192/449 (42%), Gaps = 5/449 (1%)
Query: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688
+HQ LA + + ++ Q ++ + + + + ++ + +A L+ +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748
+L E + QL + +L++ + E + G D V K + +
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLH 1808
E V A L A++ V E ++++ E LLE L R ++L A+ EL + H
Sbjct: 141 E-VGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 198
Query: 1809 GARQALARVQHKQQ-QLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQ 1867
LA VQ + + G L A + +++ +IQA P++++V + L
Sbjct: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258
Query: 1868 KAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927
+ +AE + R ++ + AWA L+ ++ R+Q+L +++ V E+ W+ E
Sbjct: 259 -SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 317
Query: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEK 1987
L M ++++ +D S ++K ++ +E + + + LL H +E+IS +
Sbjct: 318 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRR 377
Query: 1988 LSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDE 2047
SQ+ E +E+ L+ + R E W+ +E + S ELG +
Sbjct: 378 QSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEH 437
Query: 2048 VESLIKRHEAF-QKSAVAWEERFCALEKL 2075
V L ++ F ++ +A ER A+ ++
Sbjct: 438 VSVLQEKFSEFASETGMAGRERLAAVNQM 466
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 483 bits (1244), Expect = e-136
Identities = 361/1445 (24%), Positives = 653/1445 (45%), Gaps = 97/1445 (6%)
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774
A + R E+ +++ + ER Q+L + L F+ DA+D+ W+++ + +++
Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
Query: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDAL---REQAAALPPTLSRTPEVQGRVPTLE 831
D + Q ++H++LE E+++ + L RE+ + S E + + L
Sbjct: 81 Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH--SAHEETKAHIEELR 137
Query: 832 RHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQ 891
++ L E+ L AL + E W+ +KE + L E E EV+
Sbjct: 138 HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLH 197
Query: 892 QRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKK 951
++FE + E+ ++ VN A + + N P I + Q ++N W++ R LA ++
Sbjct: 198 KKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
Query: 952 AALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAI 1011
AL++A ++Q + + TE W++EK V+ S + G DL L G ER+L +
Sbjct: 258 KALSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVM 316
Query: 1012 AARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFL 1071
+ +V EL +A L HP+ A I ++ + WE +RA R E L F
Sbjct: 317 SDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFS 376
Query: 1072 RSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEV 1131
D+ W+ A+ ++E P + E LL +H + E++ + G+++
Sbjct: 377 SDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL 436
Query: 1132 TRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQ 1191
+ +R+++E L W L +W+ R + Q F F RD+ Q + +S Q
Sbjct: 437 VNANHEASDE-VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQ 495
Query: 1192 EYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
E L + ++ +L +A+A ++K EDF A E+I + + +L+ + + ++ I+
Sbjct: 496 EAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARN 1311
D + R ++ A L+++ Q +D +LK WI++K A D Y + +N
Sbjct: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQN 615
Query: 1312 LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETT 1371
L ++ QK Q F ELA NK L+ + K G+E+ V+ +L ++ W+EL
Sbjct: 616 LKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEA 675
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWE 1431
T+ K L +AN+ F + L+ WLE ++ Q+ S+DYGK L V L+K +LE
Sbjct: 676 TKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESA 735
Query: 1432 MAVREKEVEAIQAQAKALAQ-EDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQ 1490
+A R+ +V+ + A + + ++ ++ +F AL +P+ R ++L
Sbjct: 736 VAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHL 795
Query: 1491 HQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRER 1550
RD EDE W+ E P A+S GKDL + + L+ +++ + + I HEPRI ++ ER
Sbjct: 796 QLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855
Query: 1551 QRAL------GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWM 1604
+ A + L + + L R LE ++ QQ+ D EAE W+
Sbjct: 856 GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915
Query: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVL----------EQALADYAQTIHQLAASSQD- 1653
E+E + DE +A A +KKH+ +AL + A Q A+ +
Sbjct: 916 REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEG 975
Query: 1654 ---------MIDHEHPESTRISIRQAQVDKL---------------YAGLKELAGERRER 1689
+ D + +++++ V L + G+ RR
Sbjct: 976 VAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035
Query: 1690 LQEHLRLCQLRRE-------------------LDDLEQWIQEREVVAASHELGQDYEHVT 1730
E L Q RRE LD E+ + R ++ +E YE
Sbjct: 1036 HDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEE--RRRRLLQRYNEFLLAYEAGD 1093
Query: 1731 ML---------------------RDKFREFSRDTSTIGQERVDSANALANGLIAGGHAAR 1769
ML + KF EF +D +T + R+ N +A+ L+ G
Sbjct: 1094 MLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDLLFEG-LLT 1151
Query: 1770 ATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG-T 1828
A+ + LN W L L D + Q+L +A+ ++ F A +++ K Q L
Sbjct: 1152 PEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP 1211
Query: 1829 GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEA 1888
G DL + +ALQRRH +E D+ L +V + + RL +++ D E++ R + EA
Sbjct: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKMELNEA 1270
Query: 1889 WAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKN 1948
W LQG + R++ L + + F R+L W+ + + +QE D++ +++++
Sbjct: 1271 WEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLER 1330
Query: 1949 QQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDW 2008
Q +A++EA A F + D EL+ H+A+ EI +KL ++ R + + W+++
Sbjct: 1331 HQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKI 1390
Query: 2009 LQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEER 2068
L LE+ +F + E+W+ ++E +RS + ++D +E+L+K+ + K+ A E +
Sbjct: 1391 LDQCLELQMFQGNCDQVESWMVARENSLRSDDKS-SLDSLEALMKKRDDLDKAITAQEGK 1449
Query: 2069 FCALE 2073
LE
Sbjct: 1450 ITDLE 1454
Score = 461 bits (1186), Expect = e-129
Identities = 417/1643 (25%), Positives = 736/1643 (44%), Gaps = 103/1643 (6%)
Query: 234 HYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRI 293
H + + AF E+++ + + D D ++I A ++ AL +
Sbjct: 518 HEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENI---KAIRDGLLARRDALREKAATR 574
Query: 294 GKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLND---RQLANSLSGVQNQLQSFNSY 350
++L ++ ++L E + +L WI + +D + + N S VQ Q Q F
Sbjct: 575 RRLLKESLLLQKLYED----SDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQ-QVFEKE 629
Query: 351 RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERE 410
V K LE + T Q + + + +S++ WE L +A ++
Sbjct: 630 LAVNKT-------QLENIQKTGQEMIEGGHYA--SDNVTTRLSEVASLWEELLEATKQKG 680
Query: 411 LALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAI 470
L E +QL +F+ A + WL + + V+ +++G LA V+ +RKH +
Sbjct: 681 TQLH------EANQQL--QFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLL 732
Query: 471 ETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLN 530
E+ + A +V + +AA + D K I ARQ ++ ++ L++ +A R+++LL
Sbjct: 733 ESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDL 792
Query: 531 LELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAV 590
L LQ + +D W++E + S LG+ L + LL H ++ +IA R++ +
Sbjct: 793 LHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852
Query: 591 SASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEV 650
+ + G + V+ RV L Q+ E+L AA R+ LE + + ++L ++
Sbjct: 853 TERGNKMVEEGH----FAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADL 908
Query: 651 GEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAE 710
EAE W+RE++ ++ + + G D A LL KH A +++ +K Q
Sbjct: 909 HEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQ------- 961
Query: 711 GHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADA-NDMEAWLVDALRL 769
A A + Q Q +E +A E+ + +LY FQA + ++ D L L
Sbjct: 962 ---------ANACQ-QQQAAPVEGVAGEQ-----RVMALYDFQARSPREVTMKKGDVLTL 1006
Query: 770 VSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTP-EVQGRVP 828
+SS + D + +A H+ + + R D + LP P + R
Sbjct: 1007 LSS--INKDWWKVEAA--DHQGIVPAVYVRRLAHD----EFPMLPQRRREEPGNITQRQE 1058
Query: 829 TLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888
+E Y L RA ER R L + + EAG W++EK+ G+ L+D+
Sbjct: 1059 QIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGV----ELDDVW 1114
Query: 889 VVQQRFETLEPEMNTLAAQITAVNDIAEQLL---KANPPGKDRIVNTQEQLNHRWQQFRR 945
+Q++F+ + ++NT ++ +N +A+ LL P G +++LN RW +R
Sbjct: 1115 ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEG----AQIRQELNSRWGSLQR 1170
Query: 946 LADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTE 1005
LAD ++ L SA +++ +H E +T+ + +K + + + G+DL V ALQR+ G E
Sbjct: 1171 LADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP-GSDLFSVQALQRRHEGFE 1229
Query: 1006 RDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR 1065
RDL + +V L A L+ HP + + E+ WEDL+ + R+ESL EA+
Sbjct: 1230 RDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQ 1289
Query: 1066 RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR 1125
+ FL D Q W+ V+S+E L E LL +H R ++E + L
Sbjct: 1290 KFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALE 1349
Query: 1126 ALGEEV--TRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQ 1183
E+ + A P+ + ++L+A+ ++L + WE R+ L Q Q F + Q
Sbjct: 1350 DFSAELIDSGHHASPE---IEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQ 1406
Query: 1184 AEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGN 1243
E + ++E L ++ +L + +A +KK +D + A +I L L+++ +
Sbjct: 1407 VESWMVARENSL-RSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEH 1465
Query: 1244 IHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQD 1303
++I + + R K + +L D + F +D EL+ WI E + TA D
Sbjct: 1466 YAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACD 1525
Query: 1304 VSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPEL---KALVSEKLRD 1360
SY +A N+ K+ KHQ F E+ + + V G L +E + + E+L
Sbjct: 1526 ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSL-IECSACDGNEEAMKEQLEQ 1584
Query: 1361 LHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNI 1420
L WD L T K + L +A+R + F S E WL + L D +DL S
Sbjct: 1585 LKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGN 1644
Query: 1421 LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ-GAGEVERTSRAVEEKFRALCQPMRE 1479
LLKK Q+LE EM RE ++ + A+ L ++ + V ++F + +
Sbjct: 1645 LLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAA 1704
Query: 1480 RCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQG 1539
+L+ + QF +D++DE W+ E+L SS ++G+DL VQ L+KK++ L+ E+
Sbjct: 1705 HHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVA 1764
Query: 1540 HEPRIADLRERQRAL-GAAAAGPE-----LAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
HEP I ++ + L AA G E LA+ E W++L + RG +LE++L QF
Sbjct: 1765 HEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQF 1824
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
++A E EAW+ E+ + + + Q+ + KH+ LE A + + + A +D
Sbjct: 1825 MQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGED 1884
Query: 1654 MID---HEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
+++ E ++ IS + +++ L + + +L++ + + D +E WI
Sbjct: 1885 ILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWI 1944
Query: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
++E ++ G D L K + QER+ L + LI+ H
Sbjct: 1945 ADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSK 2004
Query: 1771 TVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR 1830
+ E +L + W LLE Q L E Q L A HK L + +
Sbjct: 2005 AIEERYAALLKRWEQLLEASAVHRQKL---LEKQLPLQKAEDLFVEFAHKASALNNWCEK 2061
Query: 1831 -DLNAAEALQRRHCAYEHDIQAL 1852
+ N +E + HC ++I+ L
Sbjct: 2062 MEENLSEPV---HCVSLNEIRQL 2081
Score = 366 bits (939), Expect = e-100
Identities = 382/1814 (21%), Positives = 743/1814 (40%), Gaps = 136/1814 (7%)
Query: 386 PREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAAR---------FDRKAAM 436
P+E + S K E E+ + R+ L +E++ + + F R A
Sbjct: 5 PKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
Query: 437 RETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERY 496
W+ E +++ ++ + ++ +KH+++E ++ S + ++ E +
Sbjct: 65 LGKWIMEKVNILTDKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH 123
Query: 497 HDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQS 556
+ A + LWD L ++ + ++LL L+ Q+ Q+ +++W+ + + S
Sbjct: 124 SAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATS 183
Query: 557 QDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERV 616
+LG E L + E + ++ + RV V+ ++ N E D L+ +
Sbjct: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVN----QYANECAEENHPDLPLIQSKQ 239
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
++ ++E L LA R+ L + L RF +V EA W++E++ +L S D G+DL +
Sbjct: 240 NEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVAS 299
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALA 736
L + H L ++ +K + ++L A Q +L + WE + ALA
Sbjct: 300 EGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALA 359
Query: 737 EERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
R ++L ++F +D +++ W+ + +++ EL D + L +H+ + EI
Sbjct: 360 TSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEI 419
Query: 797 RSHRPTLDALREQAAAL-PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALY 855
S+ + E L + EV+ ++ L+ ++ L ER R E L +
Sbjct: 420 DSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFH 479
Query: 856 TMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIA 915
++ W+ +E +L L L E + Q+ E E +I V+ A
Sbjct: 480 LFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTA 539
Query: 916 EQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMR 975
+L+ + + I ++ L R R A ++ L +L +Q + + + + W+
Sbjct: 540 TKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWIN 599
Query: 976 EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVA 1035
+K K+ + D+ + + +K E++L ++ + + + G +
Sbjct: 600 KKKKLADDED--YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN 657
Query: 1036 INARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPA 1095
+ RL EV + WE+L +++ L EA + F + +D Q WL + V SE+
Sbjct: 658 VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGK 717
Query: 1096 TLPEAEALLAQHAALRGEVERAQSE---YSRLRALGEEVTRDQADPQCLFLRQRLEALGT 1152
L E + L +H L V Q + + L A EE+ P +R R E+L
Sbjct: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEI----GHPDSKDIRARQESLVC 773
Query: 1153 GWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIK 1212
+E L +R+ +L Q RD E + E + T + L A+ +
Sbjct: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833
Query: 1213 KLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLG 1272
+ + + ++ RI + E G ++V EG+ A+ + + S+ + + + A +
Sbjct: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQN 893
Query: 1273 RLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSY---DEARNLHTKWQKHQAFMAELAAN 1329
L N + Q +L D HE + WI EK + +Y +EA K KH+AF+ +L +
Sbjct: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLK--KHEAFLLDLNSF 951
Query: 1330 KDWL-------------------------------DKVDKEGRELTLEKPELKALVSEKL 1358
D + D + RE+T++K ++ L+S
Sbjct: 952 GDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSIN 1011
Query: 1359 RDL-----------------------------HRRWDELETTTQAKA------RSLFDAN 1383
+D RR +E TQ + RSL D
Sbjct: 1012 KDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLD-- 1069
Query: 1384 RAE-------------LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
RAE L A + W++ +A ++ G +L V L KK +
Sbjct: 1070 RAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKA----ENTGVELDDVWELQKKFDEFQK 1125
Query: 1431 EMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQ 1490
++ E + I A L E E + + + ++ +L + E+ + L ++
Sbjct: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAV 1185
Query: 1491 HQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRER 1550
FHR+ +D + ++ S+ + G DL SVQ L ++++ ++++ ++ L E
Sbjct: 1186 EVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGET 1245
Query: 1551 QRALGAAAAGP------ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWM 1604
L + + EL E W+ L + R + L +A + F A + + W+
Sbjct: 1246 AERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWI 1305
Query: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTR 1664
+ QE A+D + +++HQ + A T L S ++ID H S
Sbjct: 1306 SSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPE 1365
Query: 1665 ISIRQAQVDKLYAGLKELAGERRER-LQEHLRLCQLRRELDDLEQWIQEREVVAASHELG 1723
I ++ Q KL E A E+R++ L + L L + D +E W+ RE S +
Sbjct: 1366 IE-KKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKS 1424
Query: 1724 --QDYEHVTMLRDKFREFSRDTSTIGQE-RVDSANALANGLIAGGHAARATVAEWKDSLN 1780
E + RD D + QE ++ A LIA H A+ +A +
Sbjct: 1425 SLDSLEALMKKRDDL-----DKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVL 1479
Query: 1781 EAWADL-LELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQ 1839
+ W L +L+D R + L L++F + + D + +D +
Sbjct: 1480 DRWKALKAQLIDERTK-LGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKY 1538
Query: 1840 RRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEE-IGRHMQAVAEAWAQLQGSSAA 1898
+H + H++ S QV V + G+ L + A D EE + ++ + E W L +
Sbjct: 1539 LKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTND 1598
Query: 1899 RRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEA 1958
+ + L + + + RF ++R+ W+ E + +++ RD++SA ++K Q ++ E+ A
Sbjct: 1599 KGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLA 1658
Query: 1959 RADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVF 2018
R D + ++LL+ + ++I +K + R E + L+ + F
Sbjct: 1659 REDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQF 1718
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL 2078
+D E+W+ + V S + G + V++L+K+H+ + VA E A++ + +
Sbjct: 1719 FQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEP---AIQNVLDM 1775
Query: 2079 EEREKERKRKREEE 2092
E+ K++ +EE
Sbjct: 1776 AEKLKDKAAVGQEE 1789
Score = 324 bits (831), Expect = 6e-88
Identities = 360/1759 (20%), Positives = 722/1759 (41%), Gaps = 118/1759 (6%)
Query: 320 WIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRAN 379
W+ + L + L NSL + LQ + FT + + + +KL +
Sbjct: 491 WMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEA-----FTAQEEKIITVDKTATKLIGD 545
Query: 380 NQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRET 439
+ Y + I D L + + RE A + +E L L + + +
Sbjct: 546 DH--YDSENIKAIRD-----GLLARRDALREKAATRRRLLKESL--LLQKLYEDSDDLKN 596
Query: 440 WLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDI 499
W+++ ++L +++ ++ +++ V+K + E ++ +++ + E+ ++
Sbjct: 597 WINKKKKLADDEDYK-DIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYAS 655
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLY------LMDWMEEMKGR 553
+ R VA LW+ +++ A +++ +L + Q L + L W+E+++ +
Sbjct: 656 DNVTTRLSEVASLWE---ELLEATKQK---GTQLHEANQQLQFENNAEDLQRWLEDVEWQ 709
Query: 554 LQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVS 613
+ S+D G+ LA V++ L+ H L+E+ +A + ++V ++ A F +E D + +
Sbjct: 710 VTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYF----EEIGHPDSKDIR 765
Query: 614 ERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDL 673
R L +EAL E A R+ +L + L + + EAW++E + S G+DL
Sbjct: 766 ARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDL 825
Query: 674 TGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLE 733
+ +LLN+H + ++ ++ E+G ++V EGH A ++R L E L
Sbjct: 826 IASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLR 885
Query: 734 ALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALE 793
A A R L Q+ AD ++ E W+ + +V + G DE + AL ++H A
Sbjct: 886 ARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFL 945
Query: 794 EEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
++ S ++ ALR QA A ++ QA E + +A
Sbjct: 946 LDLNSFGDSMKALRNQANAC---------------------QQQQAAPVEGVAGEQRVMA 984
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAV-N 912
LY + + +E + + L + + E + + A + + +
Sbjct: 985 LYDFQARS--------PREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAH 1036
Query: 913 DIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQA 972
D L + I QEQ+ ++++ A+ ++ L + E +
Sbjct: 1037 DEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLE 1096
Query: 973 WMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQ 1032
W++EK + G +L V LQ+K ++DL R+ ++ + A+ L
Sbjct: 1097 WIQEK-----KAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLT 1151
Query: 1033 AVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEE 1092
R +E+ + W L+ + + LG A ++ F R DD + + + A+++ +
Sbjct: 1152 PEGAQIR-QELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAAD 1210
Query: 1093 GPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGT 1152
+ L +AL +H ++ + + L E ++ D RQ++E L
Sbjct: 1211 PGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME-LNE 1269
Query: 1153 GWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIK 1212
WE+L + R+ L +A F FL AR + +SS ++S E+ L + ++
Sbjct: 1270 AWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLE 1329
Query: 1213 KLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLG 1272
+ ++ + M+A L + +L+ G+ + +I +K +++ + A ++
Sbjct: 1330 RHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKK 1389
Query: 1273 RLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDW 1332
L E Q F +C +++ W+ + + + +L +K + A +
Sbjct: 1390 ILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGK 1449
Query: 1333 LDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSC 1392
+ ++ L ++ K ++ +L+ + RW L+ + L D + F +
Sbjct: 1450 ITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDL 1509
Query: 1393 CALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQE 1452
LE W+ + + Y KD T++ K Q E+ R ++V + +L +
Sbjct: 1510 EELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIEC 1568
Query: 1453 DQGAGEVERTSRAVE---EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLP 1509
G E +E E + L + ++ ++L + Q +F+ + D W++E
Sbjct: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
Query: 1510 MASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR---ERQRALGAAAAGPELAEL 1566
+ + + +DL S L+KK+Q L++E+ E + DL E + G + +
Sbjct: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
Query: 1567 QEMWKRLGHELELRG---KRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA 1623
+ KR + EL ++L++A QF++D + E+W+ E+ + + Q+ +D
Sbjct: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
Query: 1624 QAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELA 1683
Q +KKH+ LE L + I + ++ + D I +R AQ + + LKELA
Sbjct: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELA 1808
Query: 1684 GERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDT 1743
R +L+E L Q + ++ E WI E+ +A + G L K D
Sbjct: 1809 KARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
Query: 1744 STIGQERVDSANALANGL---IAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAA 1800
+ + + RV + A + + + ++ ++LNE L + + L
Sbjct: 1869 A-VHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
Query: 1801 YELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQ-VQQ 1858
Y Q F A A + K+ L +G G DL L + + +Q+ + + +
Sbjct: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPE 1987
Query: 1859 VQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TTDKF- 1910
+ D +L A ++++ I A+ + W QL +SA RQ LL+ D F
Sbjct: 1988 ITDLKDKLISA-QHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFV 2046
Query: 1911 RFFKAVRELMLWMDEV-----------------NLQMDAQERPRDVSSADLVIKNQQGIK 1953
F L W +++ LQ D ++ ++ A K +
Sbjct: 2047 EFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELD 2106
Query: 1954 AEIEARADRFSSCIDMGKELLARS--HYA--AEEISEKLSQLQARRQETAEKWQE----K 2005
+I+A S + E+L R+ H + EE ++L + +AR+ + E QE
Sbjct: 2107 QQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNA 2166
Query: 2006 MDWLQLVLEVLVFGRDAGM 2024
+LQ +LE + D +
Sbjct: 2167 STFLQWILETRAYFLDGSL 2185
Score = 238 bits (606), Expect = 7e-62
Identities = 222/960 (23%), Positives = 416/960 (43%), Gaps = 48/960 (5%)
Query: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAA 1207
+ L + W L R+ + ++ L AH + F R+A + + + LS + L +
Sbjct: 1159 QELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSV 1218
Query: 1208 DAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAA 1267
A ++ E F + G+++ L E +L H D + ++R+ + +A
Sbjct: 1219 QALQRRHEGFERDLVPLGDKVTILGETAERLSES---HPDA----TEDLQRQKMELNEAW 1271
Query: 1268 QQFLGRLRDNREQQH-------FLQDCHELKLWIDE--KMLTAQDVSYDEARNLHTKWQK 1318
+ GR +D +E + FL +L+ WI M+++Q+++ D + ++
Sbjct: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED-LTGIEILLER 1330
Query: 1319 HQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARS 1378
HQ A++ A ++ EL + +KL+ + D+LE + + +
Sbjct: 1331 HQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKI 1390
Query: 1379 LFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKE 1438
L ++F +C +ESW+ + + L SDD L S+ L+KK+ L+ + +E +
Sbjct: 1391 LDQCLELQMFQGNCDQVESWMVARENSLRSDDKSS-LDSLEALMKKRDDLDKAITAQEGK 1449
Query: 1439 VEAIQAQAKAL-AQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDV 1497
+ ++ A++L A E E+ + V ++++AL + + +L QF+RD+
Sbjct: 1450 ITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDL 1509
Query: 1498 EDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL--- 1554
E+ W++E LP A E KD ++Q K+QT E+ G ++ + +L
Sbjct: 1510 EELEEWISEMLPTACD-ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIEC 1568
Query: 1555 -----GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A +L +L+E W L +GK+L +A R Q+F + E W+ E E
Sbjct: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+ +++A+D SA +KKHQ+LE+ + + L ++D++ +I ++
Sbjct: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
V+K + ++ELA E+L+E L Q ++LDD E WI+E+ + +S + G+D + V
Sbjct: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
Query: 1730 TMLRDKFREFSRDT---STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL 1786
L K + + Q +D A L + G + +A++ E W L
Sbjct: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFV----EHWEKL 1804
Query: 1787 LELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG-TGRDLNAAEALQRRHCAY 1845
EL RG L + E +F+ A + A + K G G L A ++L +H A
Sbjct: 1805 KELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEAL 1864
Query: 1846 EHDIQALSPQVQQVQDDGHRLQKAYAGDKAE--EIGRHMQAVAEAWAQLQGSSAARRQLL 1903
E+D +VQ V G + ++++ EI ++A+ E L + AA + L
Sbjct: 1865 ENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQL 1924
Query: 1904 LDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEA-RADR 1962
D F + W+ + + D+ ++ Q + A +++ + +R
Sbjct: 1925 EDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQER 1984
Query: 1963 FSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAE-------KWQEKMDWLQLVLEV 2015
D+ +L++ H ++ I E+ + L R ++ E K EK LQ ++
Sbjct: 1985 LPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDL 2044
Query: 2016 LV-FGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERF-CALE 2073
V F A W E + +++E+ L K HE F S + F C LE
Sbjct: 2045 FVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLE 2104
Score = 195 bits (496), Expect = 4e-49
Identities = 293/1416 (20%), Positives = 591/1416 (41%), Gaps = 154/1416 (10%)
Query: 311 ESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVL-L 369
E A LL+ E ++ LN +S+ ++NQ N+ + + P G V+ L
Sbjct: 931 EEAAGALLKKHEAFLLDLNS--FGDSMKALRNQA---NACQQQQAAPVEGVAGEQRVMAL 985
Query: 370 FTIQSKLRANNQKVYTPREG---RLISDINKAWERLEKAEHE--------RELA------ 412
+ Q A + + T ++G L+S INK W ++E A+H+ R LA
Sbjct: 986 YDFQ----ARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPM 1041
Query: 413 ----LRTE----LIRQEKLE-QLAARFDRKAAMRETWLSE-NQRLVSQD----------- 451
R E RQE++E Q + DR R L N+ L++ +
Sbjct: 1042 LPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK 1101
Query: 452 ---NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHN 508
N G+EL V +K + + D+ R++ ++ VA +L E + RQ
Sbjct: 1102 KAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQEL 1161
Query: 509 VARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVED 568
+R W L+++ +R+ L ++ ++ + +E+ L + D G L V+
Sbjct: 1162 NSR-WGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQA 1220
Query: 569 LLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCE 628
L + HE E D+ ++V + +A R E P + + + +L +++E L
Sbjct: 1221 LQRRHEGFERDLVPLGDKVTILGETAERL----SESHPDATEDLQRQKMELNEAWEDLQG 1276
Query: 629 LAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRG 688
R+ L E+++ + FL + + + W+ +++S + DLTG LL +H R
Sbjct: 1277 RTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRA 1336
Query: 689 EMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAAS 748
+M + + +L+ GH + + + ++ + + LE E+R + L Q
Sbjct: 1337 DMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLE 1396
Query: 749 LYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALRE 808
L FQ + + +E+W+V + S + + S +AL ++ L++ I + + L
Sbjct: 1397 LQMFQGNCDQVESWMVARENSLRSDDKSSLD-SLEALMKKRDDLDKAITAQEGKITDLEH 1455
Query: 809 QAAALPPTLSRTPEVQGRVPTLERHY--EELQARAG---ERARALEAALA-LYTMLSEAG 862
A +L + HY EE+ R +R +AL+A L T L +
Sbjct: 1456 FAESL---------------IADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA 1500
Query: 863 ACGLW---VEEKEQWLNGL---ALPERLEDLEVVQQRF---ETLEPEMNTLAAQITAVND 913
+ +EE E+W++ + A E +D +Q+++ +T E++ + Q+ V +
Sbjct: 1501 NLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVIN 1560
Query: 914 IAEQLLKANP-PGKDRIVNTQ-EQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQ 971
+ L++ + G + + Q EQL W + K L A Q ++ + +
Sbjct: 1561 LGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFE 1620
Query: 972 AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
W+ E ++ + + DLA L +K ER++ A + +L A L +
Sbjct: 1621 FWLSEAETLL-AMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTF 1679
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASE 1091
I + V + +++ E L EA L F + LDD ++W+ V+S+
Sbjct: 1680 NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ 1739
Query: 1092 EGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALG 1151
+ L + LL +H L GE+ + + + E++ +D+A ++ RL
Sbjct: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKL-KDKAAVGQEEIQLRLAQFV 1798
Query: 1152 TGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAI 1211
WE+L + ++R +L ++ + F+++A + E ++ + + + TL A + +
Sbjct: 1799 EHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLL 1858
Query: 1212 KKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFL 1271
K E + + R+ + G ++++ + +E + IE ++K A+
Sbjct: 1859 MKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIA 1918
Query: 1272 G---RLRDNREQQHFLQDCHELKLWIDEKMLTAQ-DVSYDEARNLHTKWQKHQAFMAELA 1327
+L D+ Q F ++ WI +K + + + + + + T K A L
Sbjct: 1919 AWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQ 1978
Query: 1328 A-NKDWLDKV-DKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDAN-- 1383
+ ++ L ++ D + + ++ + + KA + E+ L +RW++L + + L +
Sbjct: 1979 SFQQERLPEITDLKDKLISAQHNQSKA-IEERYAALLKRWEQLLEASAVHRQKLLEKQLP 2037
Query: 1384 --RAE----LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
+AE FA AL +W E ++ L + L + L K + +A +
Sbjct: 2038 LQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQA 2097
Query: 1438 EVEAI---QAQAKALAQEDQG-----AGEVERT----SRAVEEKFRALCQPMRERCRRLQ 1485
+ + + Q KAL +ERT S +EE+ + L +E R+++
Sbjct: 2098 DFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQEL---QKEEARQVK 2154
Query: 1486 ASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIA 1545
+F ++ + W+ E A ++ L+K+ TL+ +++ +
Sbjct: 2155 NFEMCQEFEQNASTFLQWILET--RAYFLDGS--------LLKETGTLESQLEAN----- 2199
Query: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMG 1605
+ +Q+ E+Q M ++L ++L G LEDAL Y A+ W
Sbjct: 2200 --KRKQK------------EIQAMKRQLTKIVDL-GDNLEDALILDIKYSTIGLAQQWDQ 2244
Query: 1606 EQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYA 1641
+L + Q + ++ A+ ++K V E+ L +++
Sbjct: 2245 LYQLGLRMQHNLEQQIQAK-DIK--GVSEETLKEFS 2277
Score = 184 bits (467), Expect = 9e-46
Identities = 164/770 (21%), Positives = 343/770 (44%), Gaps = 26/770 (3%)
Query: 1354 VSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK 1413
+ E+ +++ R+ + + + L D+ ++F + L W+ + + +D +
Sbjct: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIME-KVNILTDKSYE 82
Query: 1414 DLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEK---F 1470
D T++ +K Q LE E+ + + + ++ + + G E T +EE +
Sbjct: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREE--RFTMGHSAHEETKAHIEELRHLW 140
Query: 1471 RALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKN 1530
L + E+ +L + + Q+ ++ D + W+ ++ +A+S+E G+D ++L KK
Sbjct: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
Query: 1531 QTLQKEIQGHEPRIADLRERQRALGAAAAGPELA-------ELQEMWKRLGHELELRGKR 1583
+ Q E+ E R+ ++ + A P+L E+ W+RL R K
Sbjct: 201 EDFQVELVAKEGRVVEVNQYANEC-AEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
Query: 1584 LEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQT 1643
L +A Q+F RD EA W+ E+E + ++ KD ++++ H+ LE+ LA +
Sbjct: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDK 319
Query: 1644 IHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRREL 1703
+ +L A ++ + ++ +I + + + ++ LA R E+LQ + +
Sbjct: 320 VKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDF 379
Query: 1704 DDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIA 1763
D+L W+ E+ + EL D +L D+ ++ + + +R SA+ L+
Sbjct: 380 DELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSY-DDRFQSADETGQDLVN 438
Query: 1764 GGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQ 1823
H A V E + L+ W LLEL D R + + F + Q + + ++
Sbjct: 439 ANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAF 498
Query: 1824 LP-DGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRL--QKAYAGDKAEEIGR 1880
L + G L +AEAL ++H +E A ++ V +L Y + + I
Sbjct: 499 LENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRD 558
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
+ A +A L+ +A RR+LL ++ + ++ +L W+++ D ++ +D+
Sbjct: 559 GLLARRDA---LREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDIQ 614
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAE 2000
+ ++ QQ + E+ + + G+E++ HYA++ ++ +LS++ + +E E
Sbjct: 615 NLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLE 674
Query: 2001 KWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQK 2060
++K L + L F +A + WL E V S + G + EV++ +++H +
Sbjct: 675 ATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLES 734
Query: 2061 SAVAWEERFCALEKLTALEER----EKERKRKREEEERRKQPPAPEPTAS 2106
+ A +++ L L A E + + R R+E + EP A+
Sbjct: 735 AVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLAT 784
Score = 92.8 bits (229), Expect = 4e-18
Identities = 110/528 (20%), Positives = 211/528 (39%), Gaps = 51/528 (9%)
Query: 302 EAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYR--TVEKPPKF 359
EA L + ++ L E WIE+ ++ ++ + L GVQN L+ V P
Sbjct: 1711 EAYALFQFFQDLDDEE-SWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAI 1769
Query: 360 TEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIR 419
N+ + ++ K +++ ++ + WE+L++ R L L
Sbjct: 1770 Q---NVLDMAEKLKDKAAVGQEEIQLR-----LAQFVEHWEKLKELAKARGLKL------ 1815
Query: 420 QEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSG 479
+E LE L +F + A E W++E L + + G LAA ++ + KHEA+E D +
Sbjct: 1816 EESLEYL--QFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHET 1873
Query: 480 RVQAVDAVAAEL---AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKV 536
RVQ V A ++ + K I+++ + L + +AA + L LE
Sbjct: 1874 RVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWK----LQLEDDYA 1929
Query: 537 FQDLLYLMD----WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADI-AVQAERVRAVS 591
FQ+ + D W+ + + L++ G L LL + ++A + + Q ER+ ++
Sbjct: 1930 FQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT 1989
Query: 592 ASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR--------L 643
+ + + + ER A L + +E L E +A R +L E +
Sbjct: 1990 DLKDKLISAQHN----QSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLF 2045
Query: 644 WRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQ 703
F + W + + L+ L +L H ++ K LE
Sbjct: 2046 VEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLEL 2105
Query: 704 GQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAAS--------LYQFQAD 755
QQ+ A G P + L+ W+ L + EER Q L + + +F+ +
Sbjct: 2106 DQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQN 2165
Query: 756 ANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803
A+ W+++ L + + ++ ++ ++EI++ + L
Sbjct: 2166 ASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQL 2213
Score = 40.4 bits (93), Expect = 0.021
Identities = 62/315 (19%), Positives = 124/315 (39%), Gaps = 25/315 (7%)
Query: 272 YVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDR 331
Y A + ++A AV +++ + +AE L ++ AS L W E+ L++
Sbjct: 2010 YAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEP 2069
Query: 332 QLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRL 391
SL+ ++ + + + K LE + +++A +P
Sbjct: 2070 VHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLE-----LDQQIKALGVPS-SPYTWLT 2123
Query: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
+ + + W+ L ERE L+ E RQ K ++ F++ A+ W+ E +
Sbjct: 2124 VEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDG 2183
Query: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
+ E +E+ + ++ + +I A ++ + + L DIK +A+
Sbjct: 2184 SLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTI---GLAQ 2240
Query: 512 LWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD------------WMEEMKGRLQSQDL 559
WD L Q+ R+ NLE Q +D+ + + + E + GRL ++
Sbjct: 2241 QWDQLYQLGL----RMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEF 2296
Query: 560 GRHLAGVEDLLQLHE 574
L G+ L + E
Sbjct: 2297 RSCLRGLNYYLPMVE 2311
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 444 bits (1141), Expect = e-124
Identities = 261/704 (37%), Positives = 389/704 (55%), Gaps = 45/704 (6%)
Query: 30 DSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGR 89
+ DWD D +E+ Q+KTFT W NSHL + ++ ++ D RDG
Sbjct: 35 EDDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIENIDEDFRDGL 82
Query: 90 NLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLT 149
L+ LLEV+SGE LPKP +G+MR+H + NV+KAL F+ + V L ++G+ +IVDGN ++T
Sbjct: 83 KLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMT 142
Query: 150 LGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGL 209
LG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVNV NF SW+DGL
Sbjct: 143 LGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGL 196
Query: 210 AFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED-VNVDQPDEKS 268
AFNA++H+HRP+L++++ L+K + NL NAF +AEK L + K+LD ED VN +PDEK+
Sbjct: 197 AFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKA 256
Query: 269 IITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTL 328
I+TYV+++YH FS + RI KVL E E L+E YE LAS+LL+WI +TI L
Sbjct: 257 IMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWL 316
Query: 329 NDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPRE 388
DR ++ +Q +L+ F YR V KPPK EK LE+ T+Q+KLR +N+ + P E
Sbjct: 317 EDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSE 376
Query: 389 GRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV 448
G+++SDIN W+ LE+AE E L E+ R E+L+ LA +F +KA++ E W + ++
Sbjct: 377 GKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML 436
Query: 449 S-QDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
+D L+ ++A +RKHEA E+D+ A+ RV+ + A+A EL Y+D + R
Sbjct: 437 KHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQ 496
Query: 508 NVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL---------MDWMEEMKGRLQSQD 558
+ WD L + +RRE L E Q D L+L +WME LQ
Sbjct: 497 KICDQWDALGSLTHSRRE-ALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMF 555
Query: 559 LGRHLAGVEDLLQLHELV-----------EADIAVQAERVRAVSASALRFCNPGKEYRPC 607
+ + +E L+ H+ EA +A+ E R ++ ++ + Y
Sbjct: 556 IVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKL-SGSNPYTTV 614
Query: 608 DPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWR-FLWEVGEAEAWVREQQHLLAS 666
PQ+++ + K++Q +++ + + L R F + W++ + +
Sbjct: 615 TPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGR 674
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAE 710
++ G L H P LEQ QL+ E
Sbjct: 675 ISI--EMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQE 716
Score = 57.0 bits (136), Expect = 2e-07
Identities = 97/468 (20%), Positives = 185/468 (39%), Gaps = 66/468 (14%)
Query: 1481 CRRLQASREQHQFHRDVED-----------EILWVTERLP------MASSMEHGKDLPSV 1523
C+ L ++E D E I W+ +R+P M +E +D V
Sbjct: 282 CKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRV 341
Query: 1524 QLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRL-----GHELE 1578
K + Q EI + + LR R + G ++++ W+ L G+E
Sbjct: 342 HKPPKVQEKCQLEINFNTLQ-TKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEW 400
Query: 1579 LRG--KRLE--DALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELS-AQAEVKKHQVL 1633
L +RLE D L A++F + A+ EAW +E + ++ LS +A ++KH+
Sbjct: 401 LLNEIRRLERLDHL-AEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAF 459
Query: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQE- 1692
E LA + + Q+AA +Q++ + ++ +S ++ R ++ + L L RRE L++
Sbjct: 460 ESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT 519
Query: 1693 ----------HLRLCQLRRELDD-LEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSR 1741
HL + ++ +E +++ + + H + ++ E + D+F+
Sbjct: 520 EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTI-EEIEGLISAHDQFKSTLP 578
Query: 1742 DT-----STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQV 1796
D + + + A +N + G TV +N W + +L+ R
Sbjct: 579 DADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVT--PQIINSKWEKVQQLVPKRDHA 636
Query: 1797 LAAAYELQRFLHGARQALAR--------VQHKQQQLPDGTGR---DLNAAEALQRRHC-A 1844
L Q+ R+ A +Q K +++ GR ++N Q H
Sbjct: 637 LLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEI----GRISIEMNGTLEDQLSHLKQ 692
Query: 1845 YEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
YE I P + ++ +Q+A D + M+ + W QL
Sbjct: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDN-KHTNYTMEHIRVGWEQL 739
Score = 47.4 bits (111), Expect = 2e-04
Identities = 79/435 (18%), Positives = 162/435 (37%), Gaps = 52/435 (11%)
Query: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
+++A +E L + +K+ DLL + W+E+ + Q++ + L D ++H
Sbjct: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
Query: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSE------RVAKLEQSYEALC 627
+ + Q E + LR N + P + ++VS+ + + E+ YE
Sbjct: 343 KPPKVQEKCQLEINFNTLQTKLRLSNR-PAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
Query: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTAL 686
R RL+ +F + EAW ++ +L D L+ L+ KH A
Sbjct: 402 LNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAF 459
Query: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+++ ++ Q+L + + + R ++ QW+ L +L R + L +
Sbjct: 460 ESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT 519
Query: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
++ A W+ A+ + + H + L H ++ +S
Sbjct: 520 EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAH----DQFKS 575
Query: 799 HRPTLDALREQAAALPPTLSRTPE-----VQGRVP-------TLERHYEELQARAGERAR 846
P D RE A+ R E + G P + +E++Q +R
Sbjct: 576 TLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
Query: 847 ALEAALALY--------TMLSEAGACGLWVEEKEQWLNGLA------LPERLEDLEVVQQ 892
AL + S+A G W++ K + + ++ L ++L L+ ++
Sbjct: 636 ALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYER 695
Query: 893 RFETLEPEMNTLAAQ 907
+P ++ L Q
Sbjct: 696 SIVDYKPNLDLLEQQ 710
Score = 44.3 bits (103), Expect = 0.001
Identities = 69/354 (19%), Positives = 137/354 (38%), Gaps = 35/354 (9%)
Query: 1019 TREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREE-SLGEARRLQ-------DF 1070
T + + PA + + ++ GW+ L + EE L E RRL+ F
Sbjct: 359 TLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKF 418
Query: 1071 LRSLDDFQAWL-GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGE 1129
+ +AW G+ + ATL + +AL+ +H A ++ Q ++ A+ +
Sbjct: 419 RQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478
Query: 1130 EVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHG-----FQGFLRDARQ 1183
E+ D D + R + + W+ LG + SR+ L + Q L A++
Sbjct: 479 ELNELDYYDSH--NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKR 536
Query: 1184 AEGVLSSQEYVLSHTE---MPGTLQAADAAIKKLEDFMSTM-DANGERIHGL-LEAGRQL 1238
A + E + + + T++ + I + F ST+ DA+ ER L + Q
Sbjct: 537 AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQR 596
Query: 1239 VSEGN------------IHADKIREKADSIERRHKKNQDAAQQFLGRLRDNRE-QQHFLQ 1285
++E N + I K + +++ K A + + + N ++ F
Sbjct: 597 IAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFAS 656
Query: 1286 DCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKE 1339
+ + WI KM +S + L + + + + K LD ++++
Sbjct: 657 QANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQ 710
Score = 43.5 bits (101), Expect = 0.002
Identities = 41/198 (20%), Positives = 88/198 (44%), Gaps = 25/198 (12%)
Query: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDV 1939
+H++ + + + + R + L +KFR ++ E W D +A + RD
Sbjct: 388 QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDG----KEAMLKHRDY 441
Query: 1940 SSADL-----VIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEK------- 1987
+A L +I+ + ++++ A DR + +EL +Y + ++ +
Sbjct: 442 ETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ 501
Query: 1988 ---LSQLQARRQETAEKWQEKMDWL-QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGC 2043
L L R+E EK +++++ + QL LE + + A W+ S ++ +
Sbjct: 502 WDALGSLTHSRREALEKTEKQLEAIDQLHLE---YAKRAAPFNNWMESAMEDLQDMFIVH 558
Query: 2044 TVDEVESLIKRHEAFQKS 2061
T++E+E LI H+ F+ +
Sbjct: 559 TIEEIEGLISAHDQFKST 576
Score = 42.4 bits (98), Expect = 0.006
Identities = 58/277 (20%), Positives = 116/277 (41%), Gaps = 24/277 (8%)
Query: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRL-RDNREQQHFLQDCHELKLWID--E 1296
SEG + +D I +E+ K ++ + RL R + + F Q + W D E
Sbjct: 375 SEGKMVSD-INNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 433
Query: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356
ML +D ++ +KH+AF ++LAA++D ++++ +EL V+
Sbjct: 434 AMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNT 493
Query: 1357 KLRDLHRRWDELETTTQAKARSL---------FDANRAELFAQSCCALESWLESLQAQLH 1407
+ + + +WD L + T ++ +L D E +A+ +W+ES L
Sbjct: 494 RCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLE-YAKRAAPFNNWMESAMEDLQ 552
Query: 1408 SDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQA---QAKALAQED----QGAGEVE 1460
+ + L+ + + ++E EAI A +A+ +A+ + G+
Sbjct: 553 DMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYT 612
Query: 1461 R-TSRAVEEKFRALCQ--PMRERCRRLQASREQHQFH 1494
T + + K+ + Q P R+ + S++Q H
Sbjct: 613 TVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649
Score = 36.2 bits (82), Expect = 0.40
Identities = 18/68 (26%), Positives = 40/68 (58%), Gaps = 4/68 (5%)
Query: 2018 FGRDAGMAEAWLCSQEPLVRSAELG-CTVDEVESLIKRHEAFQKSAVAWEERFCALEKLT 2076
F + A + EAW +E +++ + T+ ++++LI++HEAF+ A ++R +E++
Sbjct: 418 FRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR---VEQIA 474
Query: 2077 ALEEREKE 2084
A+ + E
Sbjct: 475 AIAQELNE 482
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 431 bits (1107), Expect = e-120
Identities = 260/687 (37%), Positives = 384/687 (55%), Gaps = 47/687 (6%)
Query: 15 IQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARV 74
+Q Y + + + + +WD D +E+ Q+KTFT W NSHL +
Sbjct: 8 VQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKA 55
Query: 75 TCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLE 134
++ ++ D R+G L+ LLEV+SGE LPKP +G+MR H + NV+KAL ++ + V L
Sbjct: 56 GTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLV 115
Query: 135 NMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYP 194
++G+ +IVDGN ++TLG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y
Sbjct: 116 SIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYR 169
Query: 195 NVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLL 254
NVN+ NF TSW+DGL A++H+HRPDL+D+ L K + N+ A +AEK L + K+L
Sbjct: 170 NVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKML 229
Query: 255 DPED-VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESL 313
D ED VN +PDE++I+TYV+ +YH F+ + RI KVL E ERL+E+YE L
Sbjct: 230 DAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERL 289
Query: 314 ASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ 373
ASELL+WI +TI L +R ++ +Q +L+ F YR KPPK EK LE+ T+Q
Sbjct: 290 ASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQ 349
Query: 374 SKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRK 433
+KLR +N+ + P EG+++SDI AW+RLE+AE E L E+ R E+LE LA +F +K
Sbjct: 350 TKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQK 409
Query: 434 AAMRETW-LSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELA 492
A+ ETW + Q L+ +D L V A +RKHEA E+D+ A+ RV+ + A+A EL
Sbjct: 410 ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
Query: 493 AERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL--------- 543
YHD + R + WD L + RRE L +L + D L+L
Sbjct: 470 ELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETI-DQLHLEFAKRAAPF 528
Query: 544 MDWMEEMKGRLQSQDLGRHLAGVEDLLQLHE-----LVEAD------IAVQAERVRAVSA 592
+WME LQ + + ++ L+ HE L EAD +A+Q E + + +
Sbjct: 529 NNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQS 588
Query: 593 SALRF--CNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEV 650
+R NP + + ++V +L + + AR+ E RR +F +
Sbjct: 589 YNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRR--QFAAQA 646
Query: 651 GEAEAWVREQQHLLASADTGRDLTGAL 677
W++ + +A + +TGAL
Sbjct: 647 NAIGPWIQNKMEEIARSSI--QITGAL 671
Score = 57.4 bits (137), Expect = 2e-07
Identities = 105/549 (19%), Positives = 211/549 (38%), Gaps = 75/549 (13%)
Query: 1481 CRRLQASREQHQFHRDVE---DEIL-WVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKE 1536
C+ L ++E + + E E+L W+ +P +E+ ++Q + KK + +
Sbjct: 270 CKVLAVNQENERLMEEYERLASELLEWIRRTIPW---LENRTPEKTMQAMQKKLEDFRDY 326
Query: 1537 IQGHEPRIAD---------------LRERQRALGAAAAGPELAELQEMWKRL-----GHE 1576
+ H+P LR R + G ++++ W+RL G+E
Sbjct: 327 RRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYE 386
Query: 1577 LEL-----RGKRLEDALRAQQFYRDAAEAEAWM-GEQELHMMGQEKAKDELSAQAEVKKH 1630
L R +RLE A++F + A+ E W G++++ + ++ +A ++KH
Sbjct: 387 EWLLNEIRRLERLEHL--AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444
Query: 1631 QVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERL 1690
+ E LA + + Q+AA +Q++ + ++ ++ ++ R ++ + L L +RRE L
Sbjct: 445 EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504
Query: 1691 QEHLRLCQLRRELD--------DLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRD 1742
+ +L + +L W++ + E + L +F
Sbjct: 505 ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT 564
Query: 1743 TSTIGQERVDSANALANGL--IAGGHAARATVAE-----WKDSLNEAWADLLELLDTRGQ 1795
ER S A+ N + + + R + + D L W + +L+ R Q
Sbjct: 565 LPEADGER-QSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
Query: 1796 VLAAAYELQRFLHGARQALAR--------VQHKQQQLPDGTGRDLNAAEALQRRHCAYEH 1847
L Q R+ A +Q+K +++ + + A E + YEH
Sbjct: 624 SLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEH 683
Query: 1848 DIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTT 1907
+I + +++ D +Q+A D + M+ + W +LLL T
Sbjct: 684 NIINYKNNIDKLEGDHQLIQEALVFDN-KHTNYTMEHIRVGW-----------ELLLTTI 731
Query: 1908 DKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCI 1967
R V +L D + + R +S + + + G+ + RA S
Sbjct: 732 --ARTINEVETQILTRDAKGITQEQMNEFR--ASFNHFDRRKNGLMDHEDFRACLISMGY 787
Query: 1968 DMGKELLAR 1976
D+G+ AR
Sbjct: 788 DLGEAEFAR 796
Score = 56.2 bits (134), Expect = 4e-07
Identities = 85/418 (20%), Positives = 155/418 (37%), Gaps = 64/418 (15%)
Query: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
+++A +E L E +++ +LL + W+E Q + + L D + H
Sbjct: 271 KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH 330
Query: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSE------RVAKLEQSYEALC 627
+ + Q E + LR N + P + ++VS+ R+ + E+ YE
Sbjct: 331 KPPKVQEKCQLEINFNTLQTKLRISNR-PAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWL 389
Query: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTAL 686
R RLE +F + E W ++ +L D LT LL KH A
Sbjct: 390 LNEIRRLERLEHLAE--KFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAF 447
Query: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+++ ++ Q+L + A + R ++ QW+RL L ++R + L +
Sbjct: 448 ESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERM 507
Query: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
L +F A W+ A+ + + H Q+L H E+ ++
Sbjct: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAH----EQFKA 563
Query: 799 HRPTLDALREQAAALPPTLSRT--------------------------PEVQGRVPTLER 832
P D R+ A+ + + +V+ VP ++
Sbjct: 564 TLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQ 623
Query: 833 HYEELQAR--AGERARALEAALALYTMLSEAGACGLWVEEKEQWL--NGLALPERLED 886
+E AR A ER R AA +A A G W++ K + + + + + LED
Sbjct: 624 SLQEELARQHANERLRRQFAA--------QANAIGPWIQNKMEEIARSSIQITGALED 673
Score = 53.5 bits (127), Expect = 2e-06
Identities = 68/329 (20%), Positives = 136/329 (41%), Gaps = 39/329 (11%)
Query: 1039 RLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWL-GRTQTAVASEEGPATL 1097
RL + + G+E+ RR E L + F + + W G+ Q + + A+L
Sbjct: 377 RLEQAEKGYEEWLLNEIRRLERLEHLA--EKFRQKASTHETWAYGKEQILLQKDYESASL 434
Query: 1098 PEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEE 1156
E ALL +H A ++ Q ++ A+ +E+ D D + + R + + W+
Sbjct: 435 TEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD--AVNVNDRCQKICDQWDR 492
Query: 1157 LGRMWESRQGRLAQAHGF-----QGFLRDARQA-------EGVLSS-QEYVLSHTEMPGT 1203
LG + + R+ L + Q L A++A EG + Q+ + H +
Sbjct: 493 LGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVH-----S 547
Query: 1204 LQAADAAIKKLEDFMSTM-DANGER---------IHGLLEAGRQLVSEGN----IHADKI 1249
++ + I E F +T+ +A+GER + ++++ +S N + D++
Sbjct: 548 IEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDEL 607
Query: 1250 REKADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDE 1308
R K D +++ + Q+ L R N R ++ F + + WI KM S
Sbjct: 608 RTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI 667
Query: 1309 ARNLHTKWQKHQAFMAELAANKDWLDKVD 1337
L + + + + + K+ +DK++
Sbjct: 668 TGALEDQMNQLKQYEHNIINYKNNIDKLE 696
Score = 44.3 bits (103), Expect = 0.001
Identities = 38/183 (20%), Positives = 75/183 (40%), Gaps = 10/183 (5%)
Query: 1271 LGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANK 1330
L RL E+ HE + E++L +D + +KH+AF ++LAA++
Sbjct: 396 LERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455
Query: 1331 DWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL---------FD 1381
D ++++ +EL V+++ + + +WD L T TQ + +L D
Sbjct: 456 DRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETID 515
Query: 1382 ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEA 1441
E FA+ +W+E L + + L+ + + + + E ++
Sbjct: 516 QLHLE-FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQS 574
Query: 1442 IQA 1444
I A
Sbjct: 575 IMA 577
Score = 42.4 bits (98), Expect = 0.006
Identities = 39/203 (19%), Positives = 91/203 (44%), Gaps = 27/203 (13%)
Query: 1879 GRHMQAVAEAWAQLQGSSAARRQLLLDT----------TDKFRFFKAVRELMLW-MDEVN 1927
G+ + +A AW +L+ + + LL+ +KFR + E + +++
Sbjct: 365 GKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQIL 424
Query: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEK 1987
LQ D + ++ +++ + ++++ A DR + +EL ++ A ++++
Sbjct: 425 LQKDYESA--SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDR 482
Query: 1988 ----------LSQLQARRQETAEKWQEKMDWL-QLVLEVLVFGRDAGMAEAWLCSQEPLV 2036
L L +R+E E+ ++ ++ + QL LE F + A W+ +
Sbjct: 483 CQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLE---FAKRAAPFNNWMEGAMEDL 539
Query: 2037 RSAELGCTVDEVESLIKRHEAFQ 2059
+ + +++E++SLI HE F+
Sbjct: 540 QDMFIVHSIEEIQSLITAHEQFK 562
Score = 33.5 bits (75), Expect = 2.6
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 14/100 (14%)
Query: 1994 RRQETAEKWQEKMDWLQLVLEVLV--------FGRDAGMAEAWLCSQEPLVRSAEL-GCT 2044
+R E AEK E +WL + L F + A E W +E ++ + +
Sbjct: 376 QRLEQAEKGYE--EWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESAS 433
Query: 2045 VDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKE 2084
+ EV +L+++HEAF+ A ++R +E++ A+ + E
Sbjct: 434 LTEVRALLRKHEAFESDLAAHQDR---VEQIAAIAQELNE 470
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 431 bits (1107), Expect = e-120
Identities = 553/2250 (24%), Positives = 910/2250 (40%), Gaps = 310/2250 (13%)
Query: 45 RSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILP 104
++ I +L DER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP
Sbjct: 8 QNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP 67
Query: 105 KPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQD 164
+ KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI D
Sbjct: 68 RE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 126
Query: 165 ISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLD 224
I V + E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D
Sbjct: 127 IQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184
Query: 225 FESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMK 284
+ + NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++
Sbjct: 185 MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244
Query: 285 ALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQL 344
+ +G R A E + ++Y L LLQW+ +R+ +S ++
Sbjct: 245 DVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 296
Query: 345 QSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEK 404
F ++ +E P K +K + + +++ ++A KV G D+ K W +L
Sbjct: 297 SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHV 353
Query: 405 AEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAV 464
A ERE LR+E R E L+++ + +A + E L++ L+ D + L A
Sbjct: 354 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVP 410
Query: 465 RKHEAIETD-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLR 517
++ +E D I VQ + + Y + R+ R + ++
Sbjct: 411 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 470
Query: 518 QMVAARRERLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVE 567
+ A + + LQ V + L YL D W+EE + R+ + G L VE
Sbjct: 471 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVE 530
Query: 568 DLL----QLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSY 623
L LH+ +E + + ER R+ L G YR C + +L+ Y
Sbjct: 531 AQLGSHRGLHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY 579
Query: 624 EALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKH 683
+L + +ARL L F+ + W+ E++ D T +
Sbjct: 580 ---AKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 636
Query: 684 TALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL 743
+AL E+ + +K G +L+ E HP + A LQ QW + L L
Sbjct: 637 SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 696
Query: 744 AQAASLYQFQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHR 800
+ A+ +QF +D + E L +ALR S + + L + + +E++ ++
Sbjct: 697 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756
Query: 801 PTLDALREQAAALPPTLSRTP--EVQGRVPTL-------------------------ERH 833
L L ++A A+ R P ++GR+P L H
Sbjct: 757 GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSH 816
Query: 834 YEELQARAGERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLAL 880
++ L + E A A EA L LW + + LA
Sbjct: 817 WKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAW 874
Query: 881 PERLEDLEVVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQ 933
D+++++ F TL+PE A ++ A + G +DR++ +
Sbjct: 875 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934
Query: 934 E--QLNHRWQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR---------- 975
E +H +QQ + L G + S L LE ET+ R
Sbjct: 935 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 994
Query: 976 --------EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TRE 1021
E+ K +GLG +A + A K+ A EL +
Sbjct: 995 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1054
Query: 1022 ANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWL 1081
+L+A + + I+ +R Q E LRA EE L EA+ +
Sbjct: 1055 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV-------------- 1096
Query: 1082 GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR- 1133
PATLPE EA A LR + E Q + LR +GE + +
Sbjct: 1097 ------------PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1144
Query: 1134 -DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDA 1181
+ D + R+R+ L W+ + + RQ L Q A +L+DA
Sbjct: 1145 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1204
Query: 1182 RQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS- 1240
R+ + + + S QA +++ + + ++ +GE++ +Q ++
Sbjct: 1205 RRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1256
Query: 1241 ----EGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDC 1287
E + K + + + + K Q ++ + D R Q+
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
Query: 1288 HELKLWIDEKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE------ 1339
L+ +E+ L Q + + R + +K + A K ++ KE
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 1340 -----GRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCA 1394
E ++ + K + E+L+ L + E QAKAR A R+ L +
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE--- 1430
Query: 1395 LESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ 1454
E + LQ + G + L + + E + ++E E ++ Q + +Q +
Sbjct: 1431 -EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489
Query: 1455 GAGEVERTSR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERL 1508
A EVE SR A EK RAL Q + E RLQA + + + + V L
Sbjct: 1490 QA-EVELASRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVAL 1545
Query: 1509 PMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE 1568
A + +K L++ +Q +A LRE A + AE +
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAER 1600
Query: 1569 MWKRLGHELELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDE 1620
+ ELE + +ALR AQQ AEAE E E + KA+++
Sbjct: 1601 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1660
Query: 1621 LSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK 1680
Q E+ + Q LE+ T Q A+ Q++I R+ Q
Sbjct: 1661 AVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ--------- 1702
Query: 1681 ELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFS 1740
GE++ +L E L +L+RE Q QE E A ++ + E + + + E S
Sbjct: 1703 ---GEQQRQLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEES 1756
Query: 1741 RDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQV 1796
R TS ++R+++ L RA E K A D E +
Sbjct: 1757 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1816
Query: 1797 LAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQA 1851
LAA E R A AL + + ++L R L EA QRR ++ DI+
Sbjct: 1817 LAAIGEATRLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEE 1871
Query: 1852 LSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD------ 1905
Q+++ D QK D + + + + A + ++A + +L L+
Sbjct: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
Query: 1906 -TTDKFRF-----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE---- 1955
D R +A R+ L +E + +A+ER + +A+ Q+ E
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 1956 IEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQ 2010
++A+ + + ++ AR A+E ++K Q + + Q+ ++ Q+ + Q
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
Query: 2011 LVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFC 2070
VL+ L +A A + + E + +VE + ++ ++ A A +
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 2071 ALEKLTALEEREKERKRKREEEERRKQPPA 2100
A EKL E+E R+ + E+ R++ A
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
Score = 123 bits (309), Expect = 2e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 1144 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1203
Query: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 1204 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1262
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322
Query: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1380
Query: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 1381 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1425
Query: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 1426 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477
Query: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1527
Query: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587
Query: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1639
Query: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 1640 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1689
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 1690 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1737
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1796
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1797 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1852
Query: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 1853 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1892
Query: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 1893 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1952
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2012
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 2013 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2059
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2113
Query: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173
Query: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2291
Query: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2467
Query: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2587
Query: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 2588 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2647
Query: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 2648 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2703
Query: 1926 VNLQMDAQ 1933
+ ++AQ
Sbjct: 2704 ALILLEAQ 2711
Score = 122 bits (307), Expect = 3e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 1102 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1161
Query: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221
Query: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 1222 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1280
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
K++ E++ + R E L Q++ ++T R +
Sbjct: 1281 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1325
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 1326 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 1382 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
Query: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 1492 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1535
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
+ L A + + + + + Q R + A+ + +
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 1596 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1708
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1764
Query: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1820
Query: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1821 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1868
Query: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 1869 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1911
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 1912 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 1968 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2081
Query: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
Query: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 2142 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2193
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2250
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 2251 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2300
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 2301 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2354
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 2355 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2407
Query: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 2408 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2461
Query: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 2462 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2514
Query: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 2515 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
Query: 2009 LQLVLEVLVFGRDAGMAEA 2027
L+ L++L A +A +
Sbjct: 2572 LREQLQLLEEQHRAALAHS 2590
Score = 117 bits (293), Expect = 1e-25
Identities = 364/1690 (21%), Positives = 633/1690 (37%), Gaps = 277/1690 (16%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
+E++ E ++ +Q I + D +L L + QL+ S K PK + G+
Sbjct: 1236 IERHGEKVEECQRFAKQYINAIKDYEL--QLVTYKAQLEPVAS---PAKKPK-VQSGSES 1289
Query: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
V+ + + + T + + IS E L + E E LA + +E+L ++
Sbjct: 1290 VIQEYVDLRTHYSELTTLTSQYIKFIS------ETLRRMEEEERLAEQQRAEERERLAEV 1343
Query: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
A +++ + E ++ + ++ L+ E VR+ EA AVDA
Sbjct: 1344 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEA-------------AVDA 1389
Query: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
+ + + +++++ RQ + A + RQ AA R RL + E++ V
Sbjct: 1390 QQQKRSIQE--ELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV---------- 1435
Query: 547 MEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRP 606
RLQ + R G E LQ A R RA A A + ++ +
Sbjct: 1436 ------RLQLEATERQRGGAEGELQ------------ALRARAEEAEAQK-----RQAQE 1472
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLAS 666
+L + + ++ +A ELA+ +A E +R R L + E E + L
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1532
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQA---SARAA 723
A+ R + L + E+ + Q ++ + E H +Q + R A
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1592
Query: 724 ELQAQWERLEALAE---ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
+ QA+ ER AE ER Q A A + QA+ + L A E +
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1652
Query: 781 ----STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSR----TPEVQGRVPTLER 832
+ + RQ E+E+ R + +Q A L R T + + + LE
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1712
Query: 833 HYEELQ---ARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEV 889
LQ A A ++ + LEA LA E E+E +RLE
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE---A 1769
Query: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
RF L E AA++ A+ + A+ + R + ++ R + R LA+
Sbjct: 1770 EAGRFRELAEE----AARLRALAEEAK---------RQRQLAEEDAARQRAEAERVLAE- 1815
Query: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLA-LQRKLAGTERDL 1008
K AA+ A ++ TE + ++EK E + L D A L+ + A + D+
Sbjct: 1816 KLAAIGEATRLK------TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869
Query: 1009 EAIAARV-----GELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE 1063
E A++ EL R+ L Q + + ++ +E A E LG
Sbjct: 1870 EERLAQLRKASDSELERQ-KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
Query: 1064 AR-RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVER----AQ 1118
R +D LRS + + R + A EE EAE + + A E R A
Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAARQRKAAL 1986
Query: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLA---QAHGFQ 1175
E RL+A EE R LR+R E +L + E+ Q RL +AH F
Sbjct: 1987 EEVERLKAKVEEARR---------LRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF- 2034
Query: 1176 GFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG---------- 1225
+ ++ + L ++ VL ++ G +AA A ++ E+ +
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2092
Query: 1226 ERIHGLLEAGRQLVSEGNIHADKIREKADS-IERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
ER+ E Q ++ A+K+R++A+ RR + Q A +Q + + + F
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152
Query: 1285 QDCHELKLWIDEKMLTA--QDVSYDEARNL-HTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
+ K +++++ T Q D +NL + Q+ +A E A + +++ R
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 1342 ELTLEKPELKALVSEK-----LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
E +LKA + + LRD L+ + + +A R + AQ L
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA 1456
QL +D + +LK++ E + E E +Q Q K LAQE
Sbjct: 2273 --------QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQE---- 2319
Query: 1457 GEVERTSRAVEEKFRALCQPMRERCRRLQASRE-QHQFHRDVEDEILWVTERLPMASSME 1515
+ R E+ + L + + R L+A R+ Q + + E L V E + E
Sbjct: 2320 -QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
Query: 1516 H------------GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL 1563
G+ L +L ++ TL + ++ ++ +Q A +
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------IQRQQSDHDAERLREAI 2430
Query: 1564 AELQEMWKRLGHE---LELRGKRLEDALRAQQFYRDAAEAEAWMGE-----QELHMMGQE 1615
AEL+ ++L E L+L+ + ++ + Q A ++++ E Q + QE
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2490
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQ----LAASSQDMIDHEHP----------E 1661
KAK E Q EV K Q L + Q + Q L AS ++ +H E
Sbjct: 2491 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2550
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE------------------- 1702
++ ++ Q ++L A + E+ + L+E R E
Sbjct: 2551 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA 2610
Query: 1703 -------------LDDLE-----QWIQEREVVAASH--ELGQDYEHVTML--RDKFREFS 1740
D L Q +QE +++A L Q + V L R+ R +
Sbjct: 2611 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2670
Query: 1741 RDTSTIG-------QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
+ S+I E++ AL L++ G A A+ A LL+ + R
Sbjct: 2671 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ------AASGFLLDPVRNR 2724
Query: 1794 GQVLAAAY-------ELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYE 1846
+ A EL L A +A+ + TG+ ++ +A+Q+ E
Sbjct: 2725 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPY------TGQQISLFQAMQKGLIVRE 2778
Query: 1847 HDIQALSPQV 1856
H I+ L Q+
Sbjct: 2779 HGIRLLEAQI 2788
Score = 115 bits (288), Expect = 5e-25
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 1126 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1181
Query: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 1182 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1240
Query: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 1301 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1350
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
A A + + ++ +V +E QQ R + + + S S
Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1408
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1465
Query: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1524
Query: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584
Query: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
Query: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1825 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
Query: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001
Query: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2041
Query: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
Query: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2161
Query: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 2162 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2214
Query: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 2215 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2256
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
AAR +VA Q A +L ++ALA ++ K
Sbjct: 2257 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2293
Query: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2342
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 2343 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2396
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 2397 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2442
Query: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2497
Query: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2498 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Score = 106 bits (264), Expect = 3e-22
Identities = 327/1505 (21%), Positives = 556/1505 (36%), Gaps = 274/1505 (18%)
Query: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1342
Query: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 1343 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1391
Query: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
QK R I QE+L+QL ++ + +A R+
Sbjct: 1392 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1417
Query: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1470
Query: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 1471 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1525
Query: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
R L E + + +A++ + A + + + ++ + L E VA
Sbjct: 1526 AERRLRQAE----VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581
Query: 619 LEQSYEA---LCELAAARRARLEESRRLWRFLWEVGEA-----EAWVREQQHLLASADTG 670
+ EA + A A RAR E R L R+ + EA +A QQ LA A+
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641
Query: 671 RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL-QAQW 729
+ A R + RG+ A + + R EL + +
Sbjct: 1642 KQKEEAEREARR----RGK-------------------------AEEQAVRQRELAEQEL 1672
Query: 730 ERLEALAEERA-QRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
E+ LAE A QRLA L + +A+ E R + EL + A ++
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGE-----QQRQLLEEELARLQREAAAATQK 1727
Query: 789 HRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARAL 848
+ LE E+ R ++ L A E + R T E+ + L+A AG
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKA--------RAEEESR-STSEKSKQRLEAEAGRFRELA 1778
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E A L + EA K Q +L + + +QR E LA ++
Sbjct: 1779 EEAARLRALAEEA---------KRQ--------RQLAEEDAARQRAEA----ERVLAEKL 1817
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
A+ + +A K++ E N R RRLA
Sbjct: 1818 AAIGEATRLKTEAEIALKEK-----EAENER---LRRLA--------------------- 1848
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E +A+ R + + E D+ LA RK + +E LE V + R+ +
Sbjct: 1849 EDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQV--- 1901
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTA 1087
+ +A+ A + G +L E LG R +D LRS + + R +
Sbjct: 1902 -EEEILALKASFEKAAAGKAEL-------ELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFL 1143
A EE EAE + + A E R A E RL+A EE R L
Sbjct: 1954 AAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------L 2002
Query: 1144 RQRLEALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
R+R E +L + E+ Q RL +AH F + ++ + L ++ VL ++
Sbjct: 2003 RERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QL 2057
Query: 1201 PGTLQAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIR 1250
G +AA A ++ E+ + ER+ E Q ++ A+K+R
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 1251 EKAD-SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYD 1307
++A+ RR + Q A +Q + + + F + K +++++ T Q D
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 1308 EARN-LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDL 1361
+N L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2237
Query: 1362 HRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNIL 1421
L+ + + +A R + AQ L QL +D + +
Sbjct: 2238 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKM 2289
Query: 1422 LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERC 1481
LK++ E + E E +Q Q K LAQE + R E+ + L + +
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQ 2343
Query: 1482 RRLQASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMK 1528
R L+A R+ Q + + E L V E + E G+ L +L +
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2403
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLE 1585
+ TL + + +++ +Q A +AEL+ ++L E L+L+ + ++
Sbjct: 2404 EKVTLVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2455
Query: 1586 DALRAQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
+ Q A ++++ E Q + QEKAK E Q EV K Q L +
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2515
Query: 1641 AQTIHQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEH 1693
Q + Q L AS ++ +H + +Q ++ +L + EL E +RL+E
Sbjct: 2516 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2575
Query: 1694 LRLCQ 1698
L+L +
Sbjct: 2576 LQLLE 2580
Score = 96.7 bits (239), Expect = 2e-19
Identities = 353/1719 (20%), Positives = 645/1719 (37%), Gaps = 237/1719 (13%)
Query: 529 LNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLL-QLHELVEADI-AVQAER 586
L L Q+ + +L L+ WM + + +E L Q + E ++ A +A++
Sbjct: 255 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 314
Query: 587 VR----------AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
R AV A L+ PG Y P D V + KL + A+ E R+
Sbjct: 315 NRSKGIYQSLEGAVQAGQLKV-PPG--YHPLD---VEKEWGKL---HVAILEREKQLRSE 365
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRD--LTGALRLLNKHTALRGEMSGRL 694
E L R + ++ + EA + E+Q A A D L A ++ + + ++
Sbjct: 366 FERLECLQRIVTKL-QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 424
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL-----AQAASL 749
++L Q L HP Q R L ERL A+ E RL A A +
Sbjct: 425 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH---ERLVAIRTEYNLRLKAGVAAPATQV 481
Query: 750 YQFQADA---------------NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEE 794
Q + D+ AW+ + V E G D S +A HR L +
Sbjct: 482 AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 541
Query: 795 EIRSHRPTLDALREQAAALPP-TLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
I R ++ R L P T + GR L+ Y +L + R R+LE+
Sbjct: 542 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGR---LDLQYAKLLNSSKARLRSLES--- 595
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVND 913
L++ ++ A +W+ EKE+ G +R ++ ++ + L E+ +I + +
Sbjct: 596 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 655
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++LL+ + P + + + Q L +W +L +A L + + + E +
Sbjct: 656 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQ 715
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT---REANA---LAA 1027
+++ + + A V L+ L + + E + G L+ + A A L
Sbjct: 716 LQKLQEALRRKYSCDRS-ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 774
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREES--LGEARRLQDFLRSLDDFQAWLGRTQ 1085
HPA + L V ++ + T+ + +E +G A+ + S +A
Sbjct: 775 RHPAHPMRGRLPLLAV-CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA------ 827
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AV S P EA A V R ++++ L L ++ D +
Sbjct: 828 -AVPSVCFLVPPPNQEAQEA--------VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 878
Query: 1146 RLEALGTGWE----ELGRMWESRQGRLAQAHGFQGFLRDARQAEG------VLSSQEYVL 1195
R L W + E RQ + +Q FLRD++ A G +++ +EY
Sbjct: 879 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 938
Query: 1196 SHTEMPGTLQAADAA----------IKKLEDFMSTMDANGER-IHGLLEAGRQLVSEGNI 1244
LQ+ + I +L+D ++A R +H L +
Sbjct: 939 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP---------L 989
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL------------QDCHELKL 1292
+ RE A I + K + G R + E + L + EL L
Sbjct: 990 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1049
Query: 1293 WIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E++ + + ++ + + + Q L A+++ L KE + + PEL+A
Sbjct: 1050 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLPELEA 1105
Query: 1353 LVS--EKLRDLHRRWDELETTTQAKARS-LFDANRAELFAQSCCALESWLESLQAQLHSD 1409
+ +KLR QA+A+ FDA R EL E LQ +
Sbjct: 1106 TKASLKKLR------------AQAEAQQPTFDALRDELRGAQEVG-----ERLQQRHGER 1148
Query: 1410 DYGKDLTSVNI--LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVE 1467
D + + LL++ Q + + VR++E+E + Q + + G + +R +
Sbjct: 1149 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1208
Query: 1468 EKFRAL----CQPMRERCRRLQASREQHQFHRDVEDE-------------------ILWV 1504
E+ +A+ Q +RE+ R+ QA E+ + H + +E + +
Sbjct: 1209 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1268
Query: 1505 TERLPMASSME--------------------HGKDLPSV--QLLMKKNQTLQKEIQGHEP 1542
+ P+AS + H +L ++ Q + ++TL++ E
Sbjct: 1269 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR--MEEEE 1326
Query: 1543 RIADLR---ERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
R+A+ + ER+R AA + +L E + + E K L+ ++ + R+ A
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
Query: 1600 AEAWMGEQELHM-MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
+A ++ + + Q + E QA+ ++ + E++ + I + + E
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR------LQLE 1440
Query: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
E R + ++ L A +E ++R+ +E RL RR++ D Q ++ EV A
Sbjct: 1441 ATERQRGGA-EGELQALRARAEEAEAQKRQAQEEAERL---RRQVQDESQRKRQAEVELA 1496
Query: 1719 SH-----ELGQDYEHVTMLRDKFREFSRDTST-IGQERVDSANALANGLIAGGHAARATV 1772
S E ++ + ++ R + + + Q V+ A + L +A A +
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1556
Query: 1773 AEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR-D 1831
+ S E A L L +A +L+ Q A + +++ R
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L A EAL+ R A E Q Q + + ++A KAEE + +AE +
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1673
Query: 1892 LQGSSA-ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Q A Q L + +A E E Q+ +E R A + +Q
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRLRAETE----QGEQQRQLLEEELARLQREAAAATQKRQ 1729
Query: 1951 GIKAEI-EARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++AE+ + RA+ E+L S AEE S S+ +R E ++
Sbjct: 1730 ELEAELAKVRAEM---------EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA-VAWEER 2068
L L + + L ++ + AE + E + I + A +A +E+
Sbjct: 1781 AARLRALA---EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1837
Query: 2069 FCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASV 2107
E+L L E E ++R+ EE+ + + E A +
Sbjct: 1838 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1876
Score = 77.4 bits (189), Expect = 2e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 951 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1008
Query: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 1009 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1062
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1122
Query: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1183 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1240
Query: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1294
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1295 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1351
Query: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1398
Query: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1399 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1453
Query: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1512
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1513 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1565
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1566 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1612
Query: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
+ ++ + Q++ +LA AE + EA +
Sbjct: 1613 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1653
Query: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1654 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
Query: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1704 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1759
Query: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1820 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1875
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 1876 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
Query: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 430 bits (1105), Expect = e-120
Identities = 555/2251 (24%), Positives = 912/2251 (40%), Gaps = 311/2251 (13%)
Query: 44 ERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEIL 103
ER+ I+ +ADER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ L
Sbjct: 57 ERAVIR-IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 115
Query: 104 PKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQ 163
P+ KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI
Sbjct: 116 PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 174
Query: 164 DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLL 223
DI V + E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+
Sbjct: 175 DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232
Query: 224 DFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKM 283
D + + NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++
Sbjct: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
Query: 284 KALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQ 343
+ +G R A E + ++Y L LLQW+ +R+ +S ++
Sbjct: 293 PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 344
Query: 344 LQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLE 403
F ++ +E P K +K + + +++ ++A KV G D+ K W +L
Sbjct: 345 WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 401
Query: 404 KAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAA 463
A ERE LR+E R E L+++ + +A + E L++ L+ D + L A
Sbjct: 402 VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 458
Query: 464 VRKHEAIETD-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL 516
++ +E D I VQ + + Y + R+ R + ++
Sbjct: 459 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 518
Query: 517 RQMVAARRERLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGV 566
+ A + + LQ V + L YL D W+EE + R+ + G L V
Sbjct: 519 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 578
Query: 567 EDLL----QLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQS 622
E L LH+ +E + + ER R+ L G YR C + +L+
Sbjct: 579 EAQLGSHRGLHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQ 627
Query: 623 YEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNK 682
Y +L + +ARL L F+ + W+ E++ D T
Sbjct: 628 Y---AKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 684
Query: 683 HTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQR 742
++AL E+ + +K G +L+ E HP + A LQ QW + L
Sbjct: 685 YSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAH 744
Query: 743 LAQAASLYQFQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSH 799
L + A+ +QF +D + E L +ALR S + + L + + +E++ +
Sbjct: 745 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 804
Query: 800 RPTLDALREQAAALPPTLSRTP--EVQGRVPTL-------------------------ER 832
+ L L ++A A+ R P ++GR+P L
Sbjct: 805 KGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPS 864
Query: 833 HYEELQARAGERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLA 879
H++ L + E A A EA L LW + + LA
Sbjct: 865 HWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLA 922
Query: 880 LPERLEDLEVVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNT 932
D+++++ F TL+PE A ++ A + G +DR++
Sbjct: 923 WQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 982
Query: 933 QE--QLNHRWQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR--------- 975
+E +H +QQ + L G + S L LE ET+ R
Sbjct: 983 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 1042
Query: 976 ---------EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TR 1020
E+ K +GLG +A + A K+ A EL
Sbjct: 1043 ARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE 1102
Query: 1021 EANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAW 1080
+ +L+A + + I+ +R Q E LRA EE L EA+ +
Sbjct: 1103 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV------------- 1145
Query: 1081 LGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR 1133
PATLPE EA A LR + E Q + LR +GE + +
Sbjct: 1146 -------------PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1192
Query: 1134 --DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRD 1180
+ D + R+R+ L W+ + + RQ L Q A +L+D
Sbjct: 1193 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252
Query: 1181 ARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS 1240
AR+ + + + S QA +++ + + ++ +GE++ +Q ++
Sbjct: 1253 ARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1304
Query: 1241 -----EGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQD 1286
E + K + + + + K Q ++ + D R Q+
Sbjct: 1305 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364
Query: 1287 CHELKLWIDEKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE----- 1339
L+ +E+ L Q + + R + +K + A K ++ KE
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 1340 ------GRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCC 1393
E ++ + K + E+L+ L + E QAKAR A R+ L +
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE-- 1479
Query: 1394 ALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED 1453
E + LQ + G + L + + E + ++E E ++ Q + +Q
Sbjct: 1480 --EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
Query: 1454 QGAGEVERTSR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTER 1507
+ A EVE SR A EK RAL Q + E RLQA + + + + V
Sbjct: 1538 RQA-EVELASRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 1508 LPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQ 1567
L A + +K L++ +Q +A LRE A + AE +
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAE 1648
Query: 1568 EMWKRLGHELELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKD 1619
+ ELE + +ALR AQQ AEAE E E + KA++
Sbjct: 1649 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1708
Query: 1620 ELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGL 1679
+ Q E+ + Q LE+ T Q A+ Q++I R+ Q
Sbjct: 1709 QAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ-------- 1751
Query: 1680 KELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREF 1739
GE++ +L E L +L+RE Q QE E A ++ + E + + + E
Sbjct: 1752 ----GEQQRQLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEE 1804
Query: 1740 SRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQ 1795
SR TS ++R+++ L RA E K A D E +
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864
Query: 1796 VLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQ 1850
LAA E R A AL + + ++L R L EA QRR ++ DI+
Sbjct: 1865 KLAAIGEATRLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIE 1919
Query: 1851 ALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD----- 1905
Q+++ D QK D + + + + A + ++A + +L L+
Sbjct: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979
Query: 1906 --TTDKFRF-----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE--- 1955
D R +A R+ L +E + +A+ER + +A+ Q+ E
Sbjct: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2039
Query: 1956 -IEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWL 2009
++A+ + + ++ AR A+E ++K Q + + Q+ ++ Q+ +
Sbjct: 2040 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2099
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERF 2069
Q VL+ L +A A + + E + +VE + ++ ++ A A +
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159
Query: 2070 CALEKLTALEEREKERKRKREEEERRKQPPA 2100
A EKL E+E R+ + E+ R++ A
Sbjct: 2160 AAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
Score = 123 bits (309), Expect = 2e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 1193 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252
Query: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 1253 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1311
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371
Query: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1429
Query: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 1430 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1474
Query: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 1475 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526
Query: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1576
Query: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636
Query: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1688
Query: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 1689 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1738
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 1739 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1786
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1845
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1846 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1901
Query: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 1902 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1941
Query: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 1942 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2001
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2061
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 2062 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2108
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2162
Query: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
Query: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2340
Query: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2516
Query: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2636
Query: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 2637 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2696
Query: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 2697 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2752
Query: 1926 VNLQMDAQ 1933
+ ++AQ
Sbjct: 2753 ALILLEAQ 2760
Score = 122 bits (307), Expect = 3e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
Query: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
Query: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 1271 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1329
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
K++ E++ + R E L Q++ ++T R +
Sbjct: 1330 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1374
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 1375 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 1431 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
Query: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 1481 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 1541 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1584
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
+ L A + + + + + Q R + A+ + +
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1644
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 1645 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1757
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1813
Query: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1869
Query: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1870 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1917
Query: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 1918 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1960
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 1961 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 2017 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2130
Query: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
Query: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 2191 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2242
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2299
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 2300 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2349
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 2350 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2403
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 2404 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2456
Query: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 2457 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2510
Query: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 2511 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2563
Query: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 2564 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620
Query: 2009 LQLVLEVLVFGRDAGMAEA 2027
L+ L++L A +A +
Sbjct: 2621 LREQLQLLEEQHRAALAHS 2639
Score = 117 bits (293), Expect = 1e-25
Identities = 364/1690 (21%), Positives = 633/1690 (37%), Gaps = 277/1690 (16%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
+E++ E ++ +Q I + D +L L + QL+ S K PK + G+
Sbjct: 1285 IERHGEKVEECQRFAKQYINAIKDYEL--QLVTYKAQLEPVAS---PAKKPK-VQSGSES 1338
Query: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
V+ + + + T + + IS E L + E E LA + +E+L ++
Sbjct: 1339 VIQEYVDLRTHYSELTTLTSQYIKFIS------ETLRRMEEEERLAEQQRAEERERLAEV 1392
Query: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
A +++ + E ++ + ++ L+ E VR+ EA AVDA
Sbjct: 1393 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEA-------------AVDA 1438
Query: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
+ + + +++++ RQ + A + RQ AA R RL + E++ V
Sbjct: 1439 QQQKRSIQE--ELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV---------- 1484
Query: 547 MEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRP 606
RLQ + R G E LQ A R RA A A + ++ +
Sbjct: 1485 ------RLQLEATERQRGGAEGELQ------------ALRARAEEAEAQK-----RQAQE 1521
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLAS 666
+L + + ++ +A ELA+ +A E +R R L + E E + L
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1581
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQA---SARAA 723
A+ R + L + E+ + Q ++ + E H +Q + R A
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1641
Query: 724 ELQAQWERLEALAE---ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
+ QA+ ER AE ER Q A A + QA+ + L A E +
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1701
Query: 781 ----STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSR----TPEVQGRVPTLER 832
+ + RQ E+E+ R + +Q A L R T + + + LE
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1761
Query: 833 HYEELQ---ARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEV 889
LQ A A ++ + LEA LA E E+E +RLE
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE---A 1818
Query: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
RF L E AA++ A+ + A+ + R + ++ R + R LA+
Sbjct: 1819 EAGRFRELAEE----AARLRALAEEAK---------RQRQLAEEDAARQRAEAERVLAE- 1864
Query: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLA-LQRKLAGTERDL 1008
K AA+ A ++ TE + ++EK E + L D A L+ + A + D+
Sbjct: 1865 KLAAIGEATRLK------TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918
Query: 1009 EAIAARV-----GELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE 1063
E A++ EL R+ L Q + + ++ +E A E LG
Sbjct: 1919 EERLAQLRKASDSELERQ-KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 1064 AR-RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVER----AQ 1118
R +D LRS + + R + A EE EAE + + A E R A
Sbjct: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAARQRKAAL 2035
Query: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLA---QAHGFQ 1175
E RL+A EE R LR+R E +L + E+ Q RL +AH F
Sbjct: 2036 EEVERLKAKVEEARR---------LRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF- 2083
Query: 1176 GFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG---------- 1225
+ ++ + L ++ VL ++ G +AA A ++ E+ +
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2141
Query: 1226 ERIHGLLEAGRQLVSEGNIHADKIREKADS-IERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
ER+ E Q ++ A+K+R++A+ RR + Q A +Q + + + F
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201
Query: 1285 QDCHELKLWIDEKMLTA--QDVSYDEARNL-HTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
+ K +++++ T Q D +NL + Q+ +A E A + +++ R
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 1342 ELTLEKPELKALVSEK-----LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
E +LKA + + LRD L+ + + +A R + AQ L
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA 1456
QL +D + +LK++ E + E E +Q Q K LAQE
Sbjct: 2322 --------QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQE---- 2368
Query: 1457 GEVERTSRAVEEKFRALCQPMRERCRRLQASRE-QHQFHRDVEDEILWVTERLPMASSME 1515
+ R E+ + L + + R L+A R+ Q + + E L V E + E
Sbjct: 2369 -QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
Query: 1516 H------------GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL 1563
G+ L +L ++ TL + ++ ++ +Q A +
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------IQRQQSDHDAERLREAI 2479
Query: 1564 AELQEMWKRLGHE---LELRGKRLEDALRAQQFYRDAAEAEAWMGE-----QELHMMGQE 1615
AEL+ ++L E L+L+ + ++ + Q A ++++ E Q + QE
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2539
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQ----LAASSQDMIDHEHP----------E 1661
KAK E Q EV K Q L + Q + Q L AS ++ +H E
Sbjct: 2540 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2599
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE------------------- 1702
++ ++ Q ++L A + E+ + L+E R E
Sbjct: 2600 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA 2659
Query: 1703 -------------LDDLE-----QWIQEREVVAASH--ELGQDYEHVTML--RDKFREFS 1740
D L Q +QE +++A L Q + V L R+ R +
Sbjct: 2660 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2719
Query: 1741 RDTSTIG-------QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
+ S+I E++ AL L++ G A A+ A LL+ + R
Sbjct: 2720 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ------AASGFLLDPVRNR 2773
Query: 1794 GQVLAAAY-------ELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYE 1846
+ A EL L A +A+ + TG+ ++ +A+Q+ E
Sbjct: 2774 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPY------TGQQISLFQAMQKGLIVRE 2827
Query: 1847 HDIQALSPQV 1856
H I+ L Q+
Sbjct: 2828 HGIRLLEAQI 2837
Score = 115 bits (288), Expect = 5e-25
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 1175 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1230
Query: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 1231 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1289
Query: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 1350 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1399
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
A A + + ++ +V +E QQ R + + + S S
Sbjct: 1400 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1457
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1514
Query: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1573
Query: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1633
Query: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693
Query: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
Query: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Query: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1874 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
Query: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050
Query: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2090
Query: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
Query: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2210
Query: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 2211 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2263
Query: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 2264 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2305
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
AAR +VA Q A +L ++ALA ++ K
Sbjct: 2306 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2342
Query: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2391
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 2392 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2445
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 2446 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2491
Query: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2546
Query: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2547 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
Score = 106 bits (264), Expect = 3e-22
Identities = 327/1505 (21%), Positives = 556/1505 (36%), Gaps = 274/1505 (18%)
Query: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1391
Query: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 1392 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1440
Query: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
QK R I QE+L+QL ++ + +A R+
Sbjct: 1441 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1466
Query: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1519
Query: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 1520 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1574
Query: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
R L E + + +A++ + A + + + ++ + L E VA
Sbjct: 1575 AERRLRQAE----VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
Query: 619 LEQSYEA---LCELAAARRARLEESRRLWRFLWEVGEA-----EAWVREQQHLLASADTG 670
+ EA + A A RAR E R L R+ + EA +A QQ LA A+
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690
Query: 671 RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL-QAQW 729
+ A R + RG+ A + + R EL + +
Sbjct: 1691 KQKEEAEREARR----RGK-------------------------AEEQAVRQRELAEQEL 1721
Query: 730 ERLEALAEERA-QRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
E+ LAE A QRLA L + +A+ E R + EL + A ++
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGE-----QQRQLLEEELARLQREAAAATQK 1776
Query: 789 HRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARAL 848
+ LE E+ R ++ L A E + R T E+ + L+A AG
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKA--------RAEEESR-STSEKSKQRLEAEAGRFRELA 1827
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E A L + EA K Q +L + + +QR E LA ++
Sbjct: 1828 EEAARLRALAEEA---------KRQ--------RQLAEEDAARQRAEA----ERVLAEKL 1866
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
A+ + +A K++ E N R RRLA
Sbjct: 1867 AAIGEATRLKTEAEIALKEK-----EAENER---LRRLA--------------------- 1897
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E +A+ R + + E D+ LA RK + +E LE V + R+ +
Sbjct: 1898 EDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQV--- 1950
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTA 1087
+ +A+ A + G +L E LG R +D LRS + + R +
Sbjct: 1951 -EEEILALKASFEKAAAGKAEL-------ELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFL 1143
A EE EAE + + A E R A E RL+A EE R L
Sbjct: 2003 AAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------L 2051
Query: 1144 RQRLEALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
R+R E +L + E+ Q RL +AH F + ++ + L ++ VL ++
Sbjct: 2052 RERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QL 2106
Query: 1201 PGTLQAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIR 1250
G +AA A ++ E+ + ER+ E Q ++ A+K+R
Sbjct: 2107 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 1251 EKAD-SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYD 1307
++A+ RR + Q A +Q + + + F + K +++++ T Q D
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 1308 EARN-LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDL 1361
+N L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 2227 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2286
Query: 1362 HRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNIL 1421
L+ + + +A R + AQ L QL +D + +
Sbjct: 2287 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKM 2338
Query: 1422 LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERC 1481
LK++ E + E E +Q Q K LAQE + R E+ + L + +
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQ 2392
Query: 1482 RRLQASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMK 1528
R L+A R+ Q + + E L V E + E G+ L +L +
Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2452
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLE 1585
+ TL + + +++ +Q A +AEL+ ++L E L+L+ + ++
Sbjct: 2453 EKVTLVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2504
Query: 1586 DALRAQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
+ Q A ++++ E Q + QEKAK E Q EV K Q L +
Sbjct: 2505 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2564
Query: 1641 AQTIHQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEH 1693
Q + Q L AS ++ +H + +Q ++ +L + EL E +RL+E
Sbjct: 2565 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2624
Query: 1694 LRLCQ 1698
L+L +
Sbjct: 2625 LQLLE 2629
Score = 96.7 bits (239), Expect = 2e-19
Identities = 353/1719 (20%), Positives = 645/1719 (37%), Gaps = 237/1719 (13%)
Query: 529 LNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLL-QLHELVEADI-AVQAER 586
L L Q+ + +L L+ WM + + +E L Q + E ++ A +A++
Sbjct: 304 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 363
Query: 587 VR----------AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
R AV A L+ PG Y P D V + KL + A+ E R+
Sbjct: 364 NRSKGIYQSLEGAVQAGQLKV-PPG--YHPLD---VEKEWGKL---HVAILEREKQLRSE 414
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRD--LTGALRLLNKHTALRGEMSGRL 694
E L R + ++ + EA + E+Q A A D L A ++ + + ++
Sbjct: 415 FERLECLQRIVTKL-QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 473
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL-----AQAASL 749
++L Q L HP Q R L ERL A+ E RL A A +
Sbjct: 474 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH---ERLVAIRTEYNLRLKAGVAAPATQV 530
Query: 750 YQFQADA---------------NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEE 794
Q + D+ AW+ + V E G D S +A HR L +
Sbjct: 531 AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 590
Query: 795 EIRSHRPTLDALREQAAALPP-TLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
I R ++ R L P T + GR L+ Y +L + R R+LE+
Sbjct: 591 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGR---LDLQYAKLLNSSKARLRSLES--- 644
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVND 913
L++ ++ A +W+ EKE+ G +R ++ ++ + L E+ +I + +
Sbjct: 645 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 704
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++LL+ + P + + + Q L +W +L +A L + + + E +
Sbjct: 705 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQ 764
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT---REANA---LAA 1027
+++ + + A V L+ L + + E + G L+ + A A L
Sbjct: 765 LQKLQEALRRKYSCDRS-ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 823
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREES--LGEARRLQDFLRSLDDFQAWLGRTQ 1085
HPA + L V ++ + T+ + +E +G A+ + S +A
Sbjct: 824 RHPAHPMRGRLPLLAV-CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA------ 876
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AV S P EA A V R ++++ L L ++ D +
Sbjct: 877 -AVPSVCFLVPPPNQEAQEA--------VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 927
Query: 1146 RLEALGTGWE----ELGRMWESRQGRLAQAHGFQGFLRDARQAEG------VLSSQEYVL 1195
R L W + E RQ + +Q FLRD++ A G +++ +EY
Sbjct: 928 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 987
Query: 1196 SHTEMPGTLQAADAA----------IKKLEDFMSTMDANGER-IHGLLEAGRQLVSEGNI 1244
LQ+ + I +L+D ++A R +H L +
Sbjct: 988 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP---------L 1038
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL------------QDCHELKL 1292
+ RE A I + K + G R + E + L + EL L
Sbjct: 1039 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1098
Query: 1293 WIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E++ + + ++ + + + Q L A+++ L KE + + PEL+A
Sbjct: 1099 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLPELEA 1154
Query: 1353 LVS--EKLRDLHRRWDELETTTQAKARS-LFDANRAELFAQSCCALESWLESLQAQLHSD 1409
+ +KLR QA+A+ FDA R EL E LQ +
Sbjct: 1155 TKASLKKLR------------AQAEAQQPTFDALRDELRGAQEVG-----ERLQQRHGER 1197
Query: 1410 DYGKDLTSVNI--LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVE 1467
D + + LL++ Q + + VR++E+E + Q + + G + +R +
Sbjct: 1198 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1257
Query: 1468 EKFRAL----CQPMRERCRRLQASREQHQFHRDVEDE-------------------ILWV 1504
E+ +A+ Q +RE+ R+ QA E+ + H + +E + +
Sbjct: 1258 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1317
Query: 1505 TERLPMASSME--------------------HGKDLPSV--QLLMKKNQTLQKEIQGHEP 1542
+ P+AS + H +L ++ Q + ++TL++ E
Sbjct: 1318 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR--MEEEE 1375
Query: 1543 RIADLR---ERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
R+A+ + ER+R AA + +L E + + E K L+ ++ + R+ A
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435
Query: 1600 AEAWMGEQELHM-MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
+A ++ + + Q + E QA+ ++ + E++ + I + + E
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR------LQLE 1489
Query: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
E R + ++ L A +E ++R+ +E RL RR++ D Q ++ EV A
Sbjct: 1490 ATERQRGGA-EGELQALRARAEEAEAQKRQAQEEAERL---RRQVQDESQRKRQAEVELA 1545
Query: 1719 SH-----ELGQDYEHVTMLRDKFREFSRDTST-IGQERVDSANALANGLIAGGHAARATV 1772
S E ++ + ++ R + + + Q V+ A + L +A A +
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1605
Query: 1773 AEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR-D 1831
+ S E A L L +A +L+ Q A + +++ R
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L A EAL+ R A E Q Q + + ++A KAEE + +AE +
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Query: 1892 LQGSSA-ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Q A Q L + +A E E Q+ +E R A + +Q
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETE----QGEQQRQLLEEELARLQREAAAATQKRQ 1778
Query: 1951 GIKAEI-EARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++AE+ + RA+ E+L S AEE S S+ +R E ++
Sbjct: 1779 ELEAELAKVRAEM---------EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1829
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA-VAWEER 2068
L L + + L ++ + AE + E + I + A +A +E+
Sbjct: 1830 AARLRALA---EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1886
Query: 2069 FCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASV 2107
E+L L E E ++R+ EE+ + + E A +
Sbjct: 1887 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1925
Score = 77.4 bits (189), Expect = 2e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 1000 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1057
Query: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 1058 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1111
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1171
Query: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1232 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1289
Query: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1343
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1344 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1400
Query: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1447
Query: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1448 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1502
Query: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1561
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1562 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1614
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1615 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1661
Query: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
+ ++ + Q++ +LA AE + EA +
Sbjct: 1662 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1702
Query: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1703 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
Query: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1753 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1808
Query: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1869 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1924
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 1925 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
Query: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 429 bits (1102), Expect = e-119
Identities = 552/2247 (24%), Positives = 908/2247 (40%), Gaps = 310/2247 (13%)
Query: 48 IKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPT 107
+K + DER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP+
Sbjct: 1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE- 59
Query: 108 KGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISV 167
KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V
Sbjct: 60 KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQV 119
Query: 168 ETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFES 227
+ E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D
Sbjct: 120 SGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNK 177
Query: 228 LKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALA 287
+ + NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++ +
Sbjct: 178 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 237
Query: 288 VEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSF 347
+G R A E + ++Y L LLQW+ +R+ +S ++ F
Sbjct: 238 -DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQF 289
Query: 348 NSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEH 407
++ +E P K +K + + +++ ++A KV G D+ K W +L A
Sbjct: 290 LKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAIL 346
Query: 408 ERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467
ERE LR+E R E L+++ + +A + E L++ L+ D + L A ++
Sbjct: 347 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRA 403
Query: 468 EAIETD-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMV 520
+E D I VQ + + Y + R+ R + ++ +
Sbjct: 404 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 463
Query: 521 AARRERLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLL 570
A + + LQ V + L YL D W+EE + R+ + G L VE L
Sbjct: 464 VAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQL 523
Query: 571 ----QLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEAL 626
LH+ +E + + ER R+ L G YR C + +L+ Y
Sbjct: 524 GSHRGLHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY--- 569
Query: 627 CELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTAL 686
+L + +ARL L F+ + W+ E++ D T ++AL
Sbjct: 570 AKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSAL 629
Query: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
E+ + +K G +L+ E HP + A LQ QW + L L +
Sbjct: 630 MRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKEN 689
Query: 747 ASLYQFQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803
A+ +QF +D + E L +ALR S + + L + + +E++ ++ L
Sbjct: 690 AAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHL 749
Query: 804 DALREQAAALPPTLSRTP--EVQGRVPTL-------------------------ERHYEE 836
L ++A A+ R P ++GR+P L H++
Sbjct: 750 SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKV 809
Query: 837 LQARAGERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPER 883
L + E A A EA L LW + + LA
Sbjct: 810 LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAWQSL 867
Query: 884 LEDLEVVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE-- 934
D+++++ F TL+PE A ++ A + G +DR++ +E
Sbjct: 868 RRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG 927
Query: 935 QLNHRWQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------- 975
+H +QQ + L G + S L LE ET+ R
Sbjct: 928 SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC 987
Query: 976 -----EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANA 1024
E+ K +GLG +A + A K+ A EL + +
Sbjct: 988 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1047
Query: 1025 LAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRT 1084
L+A + + I+ +R Q E LRA EE L EA+ +
Sbjct: 1048 LSAIYLEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV----------------- 1086
Query: 1085 QTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQ 1135
PATLPE EA A LR + E Q + LR +GE + + +
Sbjct: 1087 ---------PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1137
Query: 1136 ADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDARQA 1184
D + R+R+ L W+ + + RQ L Q A +L+DAR+
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1197
Query: 1185 EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS---- 1240
+ + + S QA +++ + + ++ +GE++ +Q ++
Sbjct: 1198 QEQIQAMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1249
Query: 1241 -EGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDCHEL 1290
E + K + + + + K Q ++ + D R Q+ L
Sbjct: 1250 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309
Query: 1291 KLWIDEKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE--------- 1339
+ +E+ L Q + + R + +K + A K ++ KE
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 1340 --GRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALES 1397
E ++ + K + E+L+ L + E QAKAR A R+ L + E
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE----EI 1422
Query: 1398 WLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAG 1457
+ LQ + G + L + + E + ++E E ++ Q + +Q + A
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA- 1481
Query: 1458 EVERTSR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMA 1511
EVE SR A EK RAL Q + E RLQA + + + + V L A
Sbjct: 1482 EVELASRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVALETA 1538
Query: 1512 SSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWK 1571
+ +K L++ +Q +A LRE A + AE + +
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAERARE 1593
Query: 1572 RLGHELELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA 1623
ELE + +ALR AQQ AEAE E E + KA+++
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1653
Query: 1624 QAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELA 1683
Q E+ + Q LE+ T Q A+ Q++I R+ Q
Sbjct: 1654 QRELAE-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ------------ 1692
Query: 1684 GERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDT 1743
GE++ +L E L +L+RE Q QE E A ++ + E + + + E SR T
Sbjct: 1693 GEQQRQLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEESRST 1749
Query: 1744 STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQVLAA 1799
S ++R+++ L RA E K A D E + LAA
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 1800 AYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQALSP 1854
E R A AL + + ++L R L EA QRR ++ DI+
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864
Query: 1855 QVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TT 1907
Q+++ D QK D + + + + A + ++A + +L L+
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1924
Query: 1908 DKFRF-----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE----IEA 1958
D R +A R+ L +E + +A+ER + +A+ Q+ E ++A
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984
Query: 1959 RADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQLVL 2013
+ + + ++ AR A+E ++K Q + + Q+ ++ Q+ + Q VL
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044
Query: 2014 EVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALE 2073
+ L +A A + + E + +VE + ++ ++ A A + A E
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104
Query: 2074 KLTALEEREKERKRKREEEERRKQPPA 2100
KL E+E R+ + E+ R++ A
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAA 2131
Score = 123 bits (309), Expect = 2e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 1134 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1193
Query: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 1194 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1252
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312
Query: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1370
Query: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 1371 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1415
Query: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 1416 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1467
Query: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 1468 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1517
Query: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1577
Query: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1629
Query: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 1630 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1679
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 1680 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1727
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1786
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1787 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1842
Query: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 1843 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1882
Query: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 1883 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1942
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2002
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 2003 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2049
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2103
Query: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2281
Query: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2457
Query: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2577
Query: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 2578 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2637
Query: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 2638 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2693
Query: 1926 VNLQMDAQ 1933
+ ++AQ
Sbjct: 2694 ALILLEAQ 2701
Score = 122 bits (307), Expect = 3e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 1092 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1151
Query: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 1152 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1211
Query: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 1212 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1270
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
K++ E++ + R E L Q++ ++T R +
Sbjct: 1271 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1315
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 1316 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 1372 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
Query: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 1422 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 1482 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1525
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
+ L A + + + + + Q R + A+ + +
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1585
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 1586 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1698
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1754
Query: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1810
Query: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1811 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1858
Query: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 1859 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1901
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 1902 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 1958 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2071
Query: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131
Query: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 2132 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2183
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2240
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 2241 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2290
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 2291 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2344
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 2345 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2397
Query: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 2398 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2451
Query: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 2452 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2504
Query: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 2505 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561
Query: 2009 LQLVLEVLVFGRDAGMAEA 2027
L+ L++L A +A +
Sbjct: 2562 LREQLQLLEEQHRAALAHS 2580
Score = 117 bits (293), Expect = 1e-25
Identities = 364/1690 (21%), Positives = 633/1690 (37%), Gaps = 277/1690 (16%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
+E++ E ++ +Q I + D +L L + QL+ S K PK + G+
Sbjct: 1226 IERHGEKVEECQRFAKQYINAIKDYEL--QLVTYKAQLEPVAS---PAKKPK-VQSGSES 1279
Query: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
V+ + + + T + + IS E L + E E LA + +E+L ++
Sbjct: 1280 VIQEYVDLRTHYSELTTLTSQYIKFIS------ETLRRMEEEERLAEQQRAEERERLAEV 1333
Query: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
A +++ + E ++ + ++ L+ E VR+ EA AVDA
Sbjct: 1334 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEA-------------AVDA 1379
Query: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
+ + + +++++ RQ + A + RQ AA R RL + E++ V
Sbjct: 1380 QQQKRSIQE--ELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV---------- 1425
Query: 547 MEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRP 606
RLQ + R G E LQ A R RA A A + ++ +
Sbjct: 1426 ------RLQLEATERQRGGAEGELQ------------ALRARAEEAEAQK-----RQAQE 1462
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLAS 666
+L + + ++ +A ELA+ +A E +R R L + E E + L
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1522
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQA---SARAA 723
A+ R + L + E+ + Q ++ + E H +Q + R A
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1582
Query: 724 ELQAQWERLEALAE---ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
+ QA+ ER AE ER Q A A + QA+ + L A E +
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1642
Query: 781 ----STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSR----TPEVQGRVPTLER 832
+ + RQ E+E+ R + +Q A L R T + + + LE
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1702
Query: 833 HYEELQ---ARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEV 889
LQ A A ++ + LEA LA E E+E +RLE
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE---A 1759
Query: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
RF L E AA++ A+ + A+ + R + ++ R + R LA+
Sbjct: 1760 EAGRFRELAEE----AARLRALAEEAK---------RQRQLAEEDAARQRAEAERVLAE- 1805
Query: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLA-LQRKLAGTERDL 1008
K AA+ A ++ TE + ++EK E + L D A L+ + A + D+
Sbjct: 1806 KLAAIGEATRLK------TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859
Query: 1009 EAIAARV-----GELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE 1063
E A++ EL R+ L Q + + ++ +E A E LG
Sbjct: 1860 EERLAQLRKASDSELERQ-KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Query: 1064 AR-RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVER----AQ 1118
R +D LRS + + R + A EE EAE + + A E R A
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAARQRKAAL 1976
Query: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLA---QAHGFQ 1175
E RL+A EE R LR+R E +L + E+ Q RL +AH F
Sbjct: 1977 EEVERLKAKVEEARR---------LRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF- 2024
Query: 1176 GFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG---------- 1225
+ ++ + L ++ VL ++ G +AA A ++ E+ +
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2082
Query: 1226 ERIHGLLEAGRQLVSEGNIHADKIREKADS-IERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
ER+ E Q ++ A+K+R++A+ RR + Q A +Q + + + F
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142
Query: 1285 QDCHELKLWIDEKMLTA--QDVSYDEARNL-HTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
+ K +++++ T Q D +NL + Q+ +A E A + +++ R
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 1342 ELTLEKPELKALVSEK-----LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
E +LKA + + LRD L+ + + +A R + AQ L
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA 1456
QL +D + +LK++ E + E E +Q Q K LAQE
Sbjct: 2263 --------QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQE---- 2309
Query: 1457 GEVERTSRAVEEKFRALCQPMRERCRRLQASRE-QHQFHRDVEDEILWVTERLPMASSME 1515
+ R E+ + L + + R L+A R+ Q + + E L V E + E
Sbjct: 2310 -QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2368
Query: 1516 H------------GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL 1563
G+ L +L ++ TL + ++ ++ +Q A +
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------IQRQQSDHDAERLREAI 2420
Query: 1564 AELQEMWKRLGHE---LELRGKRLEDALRAQQFYRDAAEAEAWMGE-----QELHMMGQE 1615
AEL+ ++L E L+L+ + ++ + Q A ++++ E Q + QE
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2480
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQ----LAASSQDMIDHEHP----------E 1661
KAK E Q EV K Q L + Q + Q L AS ++ +H E
Sbjct: 2481 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2540
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE------------------- 1702
++ ++ Q ++L A + E+ + L+E R E
Sbjct: 2541 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA 2600
Query: 1703 -------------LDDLE-----QWIQEREVVAASH--ELGQDYEHVTML--RDKFREFS 1740
D L Q +QE +++A L Q + V L R+ R +
Sbjct: 2601 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2660
Query: 1741 RDTSTIG-------QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
+ S+I E++ AL L++ G A A+ A LL+ + R
Sbjct: 2661 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ------AASGFLLDPVRNR 2714
Query: 1794 GQVLAAAY-------ELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYE 1846
+ A EL L A +A+ + TG+ ++ +A+Q+ E
Sbjct: 2715 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPY------TGQQISLFQAMQKGLIVRE 2768
Query: 1847 HDIQALSPQV 1856
H I+ L Q+
Sbjct: 2769 HGIRLLEAQI 2778
Score = 115 bits (288), Expect = 5e-25
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 1116 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1171
Query: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 1172 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1230
Query: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 1291 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1340
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
A A + + ++ +V +E QQ R + + + S S
Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1398
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 1399 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1455
Query: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1514
Query: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754
Query: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1815 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931
Query: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991
Query: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2031
Query: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091
Query: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2151
Query: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 2152 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2204
Query: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 2205 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2246
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
AAR +VA Q A +L ++ALA ++ K
Sbjct: 2247 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2283
Query: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2332
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 2333 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2386
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 2387 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2432
Query: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 2433 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2487
Query: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2488 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Score = 106 bits (264), Expect = 3e-22
Identities = 327/1505 (21%), Positives = 556/1505 (36%), Gaps = 274/1505 (18%)
Query: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332
Query: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 1333 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1381
Query: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
QK R I QE+L+QL ++ + +A R+
Sbjct: 1382 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1407
Query: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 1408 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1460
Query: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 1461 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1515
Query: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
R L E + + +A++ + A + + + ++ + L E VA
Sbjct: 1516 AERRLRQAE----VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571
Query: 619 LEQSYEA---LCELAAARRARLEESRRLWRFLWEVGEA-----EAWVREQQHLLASADTG 670
+ EA + A A RAR E R L R+ + EA +A QQ LA A+
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631
Query: 671 RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL-QAQW 729
+ A R + RG+ A + + R EL + +
Sbjct: 1632 KQKEEAEREARR----RGK-------------------------AEEQAVRQRELAEQEL 1662
Query: 730 ERLEALAEERA-QRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
E+ LAE A QRLA L + +A+ E R + EL + A ++
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGE-----QQRQLLEEELARLQREAAAATQK 1717
Query: 789 HRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARAL 848
+ LE E+ R ++ L A E + R T E+ + L+A AG
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKA--------RAEEESR-STSEKSKQRLEAEAGRFRELA 1768
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E A L + EA K Q +L + + +QR E LA ++
Sbjct: 1769 EEAARLRALAEEA---------KRQ--------RQLAEEDAARQRAEA----ERVLAEKL 1807
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
A+ + +A K++ E N R RRLA
Sbjct: 1808 AAIGEATRLKTEAEIALKEK-----EAENER---LRRLA--------------------- 1838
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E +A+ R + + E D+ LA RK + +E LE V + R+ +
Sbjct: 1839 EDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQV--- 1891
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTA 1087
+ +A+ A + G +L E LG R +D LRS + + R +
Sbjct: 1892 -EEEILALKASFEKAAAGKAEL-------ELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFL 1143
A EE EAE + + A E R A E RL+A EE R L
Sbjct: 1944 AAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------L 1992
Query: 1144 RQRLEALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
R+R E +L + E+ Q RL +AH F + ++ + L ++ VL ++
Sbjct: 1993 RERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QL 2047
Query: 1201 PGTLQAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIR 1250
G +AA A ++ E+ + ER+ E Q ++ A+K+R
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 1251 EKAD-SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYD 1307
++A+ RR + Q A +Q + + + F + K +++++ T Q D
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 1308 EARN-LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDL 1361
+N L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2227
Query: 1362 HRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNIL 1421
L+ + + +A R + AQ L QL +D + +
Sbjct: 2228 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKM 2279
Query: 1422 LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERC 1481
LK++ E + E E +Q Q K LAQE + R E+ + L + +
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQ 2333
Query: 1482 RRLQASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMK 1528
R L+A R+ Q + + E L V E + E G+ L +L +
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2393
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLE 1585
+ TL + + +++ +Q A +AEL+ ++L E L+L+ + ++
Sbjct: 2394 EKVTLVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2445
Query: 1586 DALRAQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
+ Q A ++++ E Q + QEKAK E Q EV K Q L +
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2505
Query: 1641 AQTIHQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEH 1693
Q + Q L AS ++ +H + +Q ++ +L + EL E +RL+E
Sbjct: 2506 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2565
Query: 1694 LRLCQ 1698
L+L +
Sbjct: 2566 LQLLE 2570
Score = 96.7 bits (239), Expect = 2e-19
Identities = 353/1719 (20%), Positives = 645/1719 (37%), Gaps = 237/1719 (13%)
Query: 529 LNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLL-QLHELVEADI-AVQAER 586
L L Q+ + +L L+ WM + + +E L Q + E ++ A +A++
Sbjct: 245 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 304
Query: 587 VR----------AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
R AV A L+ PG Y P D V + KL + A+ E R+
Sbjct: 305 NRSKGIYQSLEGAVQAGQLKV-PPG--YHPLD---VEKEWGKL---HVAILEREKQLRSE 355
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRD--LTGALRLLNKHTALRGEMSGRL 694
E L R + ++ + EA + E+Q A A D L A ++ + + ++
Sbjct: 356 FERLECLQRIVTKL-QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 414
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL-----AQAASL 749
++L Q L HP Q R L ERL A+ E RL A A +
Sbjct: 415 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH---ERLVAIRTEYNLRLKAGVAAPATQV 471
Query: 750 YQFQADA---------------NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEE 794
Q + D+ AW+ + V E G D S +A HR L +
Sbjct: 472 AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 531
Query: 795 EIRSHRPTLDALREQAAALPP-TLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
I R ++ R L P T + GR L+ Y +L + R R+LE+
Sbjct: 532 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGR---LDLQYAKLLNSSKARLRSLES--- 585
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVND 913
L++ ++ A +W+ EKE+ G +R ++ ++ + L E+ +I + +
Sbjct: 586 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 645
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++LL+ + P + + + Q L +W +L +A L + + + E +
Sbjct: 646 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQ 705
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT---REANA---LAA 1027
+++ + + A V L+ L + + E + G L+ + A A L
Sbjct: 706 LQKLQEALRRKYSCDRS-ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 764
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREES--LGEARRLQDFLRSLDDFQAWLGRTQ 1085
HPA + L V ++ + T+ + +E +G A+ + S +A
Sbjct: 765 RHPAHPMRGRLPLLAV-CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA------ 817
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AV S P EA A V R ++++ L L ++ D +
Sbjct: 818 -AVPSVCFLVPPPNQEAQEA--------VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 868
Query: 1146 RLEALGTGWE----ELGRMWESRQGRLAQAHGFQGFLRDARQAEG------VLSSQEYVL 1195
R L W + E RQ + +Q FLRD++ A G +++ +EY
Sbjct: 869 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 928
Query: 1196 SHTEMPGTLQAADAA----------IKKLEDFMSTMDANGER-IHGLLEAGRQLVSEGNI 1244
LQ+ + I +L+D ++A R +H L +
Sbjct: 929 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP---------L 979
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL------------QDCHELKL 1292
+ RE A I + K + G R + E + L + EL L
Sbjct: 980 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1039
Query: 1293 WIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E++ + + ++ + + + Q L A+++ L KE + + PEL+A
Sbjct: 1040 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLPELEA 1095
Query: 1353 LVS--EKLRDLHRRWDELETTTQAKARS-LFDANRAELFAQSCCALESWLESLQAQLHSD 1409
+ +KLR QA+A+ FDA R EL E LQ +
Sbjct: 1096 TKASLKKLR------------AQAEAQQPTFDALRDELRGAQEVG-----ERLQQRHGER 1138
Query: 1410 DYGKDLTSVNI--LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVE 1467
D + + LL++ Q + + VR++E+E + Q + + G + +R +
Sbjct: 1139 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1198
Query: 1468 EKFRAL----CQPMRERCRRLQASREQHQFHRDVEDE-------------------ILWV 1504
E+ +A+ Q +RE+ R+ QA E+ + H + +E + +
Sbjct: 1199 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1258
Query: 1505 TERLPMASSME--------------------HGKDLPSV--QLLMKKNQTLQKEIQGHEP 1542
+ P+AS + H +L ++ Q + ++TL++ E
Sbjct: 1259 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR--MEEEE 1316
Query: 1543 RIADLR---ERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
R+A+ + ER+R AA + +L E + + E K L+ ++ + R+ A
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376
Query: 1600 AEAWMGEQELHM-MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
+A ++ + + Q + E QA+ ++ + E++ + I + + E
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR------LQLE 1430
Query: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
E R + ++ L A +E ++R+ +E RL RR++ D Q ++ EV A
Sbjct: 1431 ATERQRGGA-EGELQALRARAEEAEAQKRQAQEEAERL---RRQVQDESQRKRQAEVELA 1486
Query: 1719 SH-----ELGQDYEHVTMLRDKFREFSRDTST-IGQERVDSANALANGLIAGGHAARATV 1772
S E ++ + ++ R + + + Q V+ A + L +A A +
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 1773 AEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR-D 1831
+ S E A L L +A +L+ Q A + +++ R
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L A EAL+ R A E Q Q + + ++A KAEE + +AE +
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1663
Query: 1892 LQGSSA-ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Q A Q L + +A E E Q+ +E R A + +Q
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRLRAETE----QGEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 1951 GIKAEI-EARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++AE+ + RA+ E+L S AEE S S+ +R E ++
Sbjct: 1720 ELEAELAKVRAEM---------EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA-VAWEER 2068
L L + + L ++ + AE + E + I + A +A +E+
Sbjct: 1771 AARLRALA---EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1827
Query: 2069 FCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASV 2107
E+L L E E ++R+ EE+ + + E A +
Sbjct: 1828 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1866
Score = 77.4 bits (189), Expect = 2e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 941 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 998
Query: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 999 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1052
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1112
Query: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1113 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1173 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1230
Query: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1284
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1285 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1341
Query: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1388
Query: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1389 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1443
Query: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1502
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1503 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1555
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1556 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1602
Query: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
+ ++ + Q++ +LA AE + EA +
Sbjct: 1603 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1643
Query: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1644 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693
Query: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1694 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1749
Query: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1865
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 1866 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922
Query: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 1923 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 427 bits (1098), Expect = e-119
Identities = 236/572 (41%), Positives = 343/572 (59%), Gaps = 30/572 (5%)
Query: 20 SDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVG 79
S N + P+ DWD D +E+ Q+KTFT W NSHL + ++
Sbjct: 6 SQQTNDYMQPEEDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIE 53
Query: 80 DLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSH 139
++ D RDG L+ LLEV+SGE L KP +G+MR+H + NV+KAL F+ + V L ++G+
Sbjct: 54 NIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE 113
Query: 140 DIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVH 199
+IVDGN ++TLG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVN+
Sbjct: 114 EIVDGNVKMTLGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNIQ 167
Query: 200 NFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED- 258
NF SW+DGL F A++H+HRP+L+D+ L+K + NL AF++AEK L + K+LD ED
Sbjct: 168 NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDI 227
Query: 259 VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318
V +PDEK+I+TYV+++YH FS + RI KVL E E+L+E YE LAS+LL
Sbjct: 228 VGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLL 287
Query: 319 QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378
+WI +TI L +R N++ +Q +L+ F YR + KPPK EK LE+ T+Q+KLR
Sbjct: 288 EWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL 347
Query: 379 NNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRE 438
+N+ + P EGR++SDIN AW LE+ E E L E+ R E+L+ LA +F +KA++ E
Sbjct: 348 SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE 407
Query: 439 TWLSENQRLVSQDNF-GLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYH 497
W + ++ Q ++ L+ ++A ++KHEA E+D+ A+ RV+ + A+A EL Y+
Sbjct: 408 AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY 467
Query: 498 DIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL---------MDWME 548
D + AR + WD L + RRE L +L + D LYL +WME
Sbjct: 468 DSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI-DQLYLEYAKRAAPFNNWME 526
Query: 549 EMKGRLQSQDLGRHLAGVEDLLQLHELVEADI 580
LQ + + ++ L HE +A +
Sbjct: 527 GAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
Score = 56.2 bits (134), Expect = 4e-07
Identities = 96/465 (20%), Positives = 180/465 (38%), Gaps = 60/465 (12%)
Query: 1481 CRRLQASREQHQFHRDVED-----------EILWVTERLP------MASSMEHGKDLPSV 1523
C+ L ++E Q D E I W+ R+P M +E +D +
Sbjct: 263 CKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRL 322
Query: 1524 QLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRL-----GHELE 1578
K + Q EI + + LR R + G ++++ W L G+E
Sbjct: 323 HKPPKVQEKCQLEINFNTLQ-TKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEW 381
Query: 1579 LRG--KRLE--DALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEVKKHQVL 1633
L +RLE D L A++F + A+ EAW +E + ++ LS +A +KKH+
Sbjct: 382 LLNEIRRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEH 1693
E LA + + Q+AA +Q++ + ++ +S ++ R ++ + L L +RRE L+
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 1694 LRLCQLRREL--------DDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTST 1745
+L + +L W++ + E + L +F
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
Query: 1746 IGQERVD--SANALANGLIAGGHAARATVAEWK----DSLNEAWADLLELLDTRGQVLAA 1799
+ER+ + + ++ H A + +N W + +L+ R Q L
Sbjct: 561 ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTE 620
Query: 1800 AYELQRFLHGARQALAR--------VQHKQQQLPDGTGR---DLNAAEALQRRHCA-YEH 1847
+ Q+ R+ +Q K +++ GR +++ Q H YE
Sbjct: 621 EHARQQHNERLRKQFGAQANVIGPWIQTKMEEI----GRISIEMHGTLEDQLSHLRQYEK 676
Query: 1848 DIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
I P++ Q++ D +Q+A D + M+ + W QL
Sbjct: 677 SIVNYKPKIDQLEGDHQLIQEALIFDN-KHTNYTMEHIRVGWEQL 720
Score = 48.9 bits (115), Expect = 6e-05
Identities = 80/426 (18%), Positives = 158/426 (37%), Gaps = 61/426 (14%)
Query: 867 WVEEKEQWLNGLALPERLEDLE---------VVQQRFETLEPEMNTLAAQITAVNDIAEQ 917
W+E + A+ ++LED VQ++ + LE NTL ++ N A
Sbjct: 296 WLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ-LEINFNTLQTKLRLSNRPAFM 354
Query: 918 LLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS--------IQNYHLECTE 969
P + R+V+ +N+ W ++ G + L + + + + + +
Sbjct: 355 ------PSEGRMVS---DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI 405
Query: 970 TQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGH 1029
+AW K ++ L+ + AL +K E DL A RV ++ A L
Sbjct: 406 HEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELD 465
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRL--------QDFLRSLDDFQAWL 1081
+ ++NAR +++ W++L A ++R E+L +L ++ + F W+
Sbjct: 466 YYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM 525
Query: 1082 GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR-------- 1133
+ T+ E + L H + + A E + + EV++
Sbjct: 526 EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVN 585
Query: 1134 -DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSS-- 1190
+P Q + W+ + ++ R L + H Q R+ G ++
Sbjct: 586 MAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVI 642
Query: 1191 --------QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG 1242
+E EM GTL+ + +++ E + ++ LE QL+ E
Sbjct: 643 GPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQ----LEGDHQLIQEA 698
Query: 1243 NIHADK 1248
I +K
Sbjct: 699 LIFDNK 704
Score = 47.4 bits (111), Expect = 2e-04
Identities = 82/436 (18%), Positives = 158/436 (36%), Gaps = 60/436 (13%)
Query: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
+++A +E L + +K+ DLL + W+E + + L D +LH
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSER------VAKLEQSYEALC 627
+ + Q E + LR N + P + ++VS+ + ++E+ YE
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNR-PAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
Query: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR-LLNKHTAL 686
R RL+ +F + EAW ++ +L D ++ LL KH A
Sbjct: 383 LNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+++ ++ Q+L + + +AR ++ QW+ L AL ++R + L +
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
L ++ A W+ A+ + + H Q L H E+ ++
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH----EQFKA 556
Query: 799 HRPTLDALR-------------------EQAAALPPTLSRTPEVQGRVPTLERHYEEL-- 837
P D R A P T E+ G+ H +L
Sbjct: 557 TLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWD----HVRQLVP 612
Query: 838 ---QARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLA------LPERLEDLE 888
QA E AR ++A G W++ K + + ++ L ++L L
Sbjct: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLR 672
Query: 889 VVQQRFETLEPEMNTL 904
++ +P+++ L
Sbjct: 673 QYEKSIVNYKPKIDQL 688
Score = 42.4 bits (98), Expect = 0.006
Identities = 31/116 (26%), Positives = 48/116 (41%), Gaps = 9/116 (7%)
Query: 1347 KPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANR--------AELFAQSCCALESW 1398
+P + D++ W LE + L + R AE F Q E+W
Sbjct: 350 RPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAW 409
Query: 1399 LESLQAQLHSDDY-GKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED 1453
+ +A L DY L+ + LLKK + E ++A + VE I A A+ L + D
Sbjct: 410 TDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELD 465
Score = 39.3 bits (90), Expect = 0.047
Identities = 20/68 (29%), Positives = 40/68 (58%), Gaps = 4/68 (5%)
Query: 2018 FGRDAGMAEAWLCSQEPLVRSAELG-CTVDEVESLIKRHEAFQKSAVAWEERFCALEKLT 2076
F + A + EAW +E ++R + T+ E+++L+K+HEAF+ A ++R +E++
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDR---VEQIA 455
Query: 2077 ALEEREKE 2084
A+ + E
Sbjct: 456 AIAQELNE 463
Score = 37.7 bits (86), Expect = 0.14
Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 4/143 (2%)
Query: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRL-RDNREQQHFLQDCHELKLWID--E 1296
SEG + +D I +E+ K ++ + RL R + + F Q + W D E
Sbjct: 356 SEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 414
Query: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356
ML +D + +KH+AF ++LAA++D ++++ +EL V+
Sbjct: 415 AMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNA 474
Query: 1357 KLRDLHRRWDELETTTQAKARSL 1379
+ + + +WD L TQ + +L
Sbjct: 475 RCQKICDQWDNLGALTQKRREAL 497
Score = 35.0 bits (79), Expect = 0.88
Identities = 41/228 (17%), Positives = 85/228 (37%), Gaps = 20/228 (8%)
Query: 304 ERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKG 363
++L +Y A+ W+E + L D + +++ +Q + ++ +K
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD---ADKE 564
Query: 364 NLEVL-LFTIQSKL---------RANNQKVYTPREGRLISDINKAWERLEKAEHERELAL 413
L +L + SK+ N TP+E IN W+ + + R+ AL
Sbjct: 565 RLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQE------INGKWDHVRQLVPRRDQAL 618
Query: 414 RTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETD 473
E RQ+ E+L +F +A + W+ + + + + +E + E
Sbjct: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMH-GTLEDQLSHLRQYEKS 677
Query: 474 IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
IV Y ++ ++ + D K ++ W+ L +A
Sbjct: 678 IVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
Score = 31.6 bits (70), Expect = 9.8
Identities = 20/78 (25%), Positives = 39/78 (50%), Gaps = 2/78 (2%)
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L+ +AL ++H A+E D+ A +V+Q+ L + D + + Q + + W
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD-SPSVNARCQKICDQWDN 485
Query: 1892 LQGSSAARRQLLLDTTDK 1909
L G+ +R+ L+ T+K
Sbjct: 486 L-GALTQKRREALERTEK 502
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 427 bits (1098), Expect = e-119
Identities = 236/572 (41%), Positives = 343/572 (59%), Gaps = 30/572 (5%)
Query: 20 SDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVG 79
S N + P+ DWD D +E+ Q+KTFT W NSHL + ++
Sbjct: 6 SQQTNDYMQPEEDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIE 53
Query: 80 DLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSH 139
++ D RDG L+ LLEV+SGE L KP +G+MR+H + NV+KAL F+ + V L ++G+
Sbjct: 54 NIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE 113
Query: 140 DIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVH 199
+IVDGN ++TLG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVN+
Sbjct: 114 EIVDGNVKMTLGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNIQ 167
Query: 200 NFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED- 258
NF SW+DGL F A++H+HRP+L+D+ L+K + NL AF++AEK L + K+LD ED
Sbjct: 168 NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDI 227
Query: 259 VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318
V +PDEK+I+TYV+++YH FS + RI KVL E E+L+E YE LAS+LL
Sbjct: 228 VGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLL 287
Query: 319 QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378
+WI +TI L +R N++ +Q +L+ F YR + KPPK EK LE+ T+Q+KLR
Sbjct: 288 EWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL 347
Query: 379 NNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRE 438
+N+ + P EGR++SDIN AW LE+ E E L E+ R E+L+ LA +F +KA++ E
Sbjct: 348 SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE 407
Query: 439 TWLSENQRLVSQDNF-GLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYH 497
W + ++ Q ++ L+ ++A ++KHEA E+D+ A+ RV+ + A+A EL Y+
Sbjct: 408 AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY 467
Query: 498 DIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL---------MDWME 548
D + AR + WD L + RRE L +L + D LYL +WME
Sbjct: 468 DSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI-DQLYLEYAKRAAPFNNWME 526
Query: 549 EMKGRLQSQDLGRHLAGVEDLLQLHELVEADI 580
LQ + + ++ L HE +A +
Sbjct: 527 GAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
Score = 56.2 bits (134), Expect = 4e-07
Identities = 96/465 (20%), Positives = 180/465 (38%), Gaps = 60/465 (12%)
Query: 1481 CRRLQASREQHQFHRDVED-----------EILWVTERLP------MASSMEHGKDLPSV 1523
C+ L ++E Q D E I W+ R+P M +E +D +
Sbjct: 263 CKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRL 322
Query: 1524 QLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRL-----GHELE 1578
K + Q EI + + LR R + G ++++ W L G+E
Sbjct: 323 HKPPKVQEKCQLEINFNTLQ-TKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEW 381
Query: 1579 LRG--KRLE--DALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEVKKHQVL 1633
L +RLE D L A++F + A+ EAW +E + ++ LS +A +KKH+
Sbjct: 382 LLNEIRRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEH 1693
E LA + + Q+AA +Q++ + ++ +S ++ R ++ + L L +RRE L+
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 1694 LRLCQLRREL--------DDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTST 1745
+L + +L W++ + E + L +F
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
Query: 1746 IGQERVD--SANALANGLIAGGHAARATVAEWK----DSLNEAWADLLELLDTRGQVLAA 1799
+ER+ + + ++ H A + +N W + +L+ R Q L
Sbjct: 561 ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTE 620
Query: 1800 AYELQRFLHGARQALAR--------VQHKQQQLPDGTGR---DLNAAEALQRRHCA-YEH 1847
+ Q+ R+ +Q K +++ GR +++ Q H YE
Sbjct: 621 EHARQQHNERLRKQFGAQANVIGPWIQTKMEEI----GRISIEMHGTLEDQLSHLRQYEK 676
Query: 1848 DIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
I P++ Q++ D +Q+A D + M+ + W QL
Sbjct: 677 SIVNYKPKIDQLEGDHQLIQEALIFDN-KHTNYTMEHIRVGWEQL 720
Score = 48.9 bits (115), Expect = 6e-05
Identities = 80/426 (18%), Positives = 158/426 (37%), Gaps = 61/426 (14%)
Query: 867 WVEEKEQWLNGLALPERLEDLE---------VVQQRFETLEPEMNTLAAQITAVNDIAEQ 917
W+E + A+ ++LED VQ++ + LE NTL ++ N A
Sbjct: 296 WLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ-LEINFNTLQTKLRLSNRPAFM 354
Query: 918 LLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS--------IQNYHLECTE 969
P + R+V+ +N+ W ++ G + L + + + + + +
Sbjct: 355 ------PSEGRMVS---DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI 405
Query: 970 TQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGH 1029
+AW K ++ L+ + AL +K E DL A RV ++ A L
Sbjct: 406 HEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELD 465
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRL--------QDFLRSLDDFQAWL 1081
+ ++NAR +++ W++L A ++R E+L +L ++ + F W+
Sbjct: 466 YYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM 525
Query: 1082 GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR-------- 1133
+ T+ E + L H + + A E + + EV++
Sbjct: 526 EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVN 585
Query: 1134 -DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSS-- 1190
+P Q + W+ + ++ R L + H Q R+ G ++
Sbjct: 586 MAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVI 642
Query: 1191 --------QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG 1242
+E EM GTL+ + +++ E + ++ LE QL+ E
Sbjct: 643 GPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQ----LEGDHQLIQEA 698
Query: 1243 NIHADK 1248
I +K
Sbjct: 699 LIFDNK 704
Score = 47.4 bits (111), Expect = 2e-04
Identities = 82/436 (18%), Positives = 158/436 (36%), Gaps = 60/436 (13%)
Query: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
+++A +E L + +K+ DLL + W+E + + L D +LH
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSER------VAKLEQSYEALC 627
+ + Q E + LR N + P + ++VS+ + ++E+ YE
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNR-PAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
Query: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR-LLNKHTAL 686
R RL+ +F + EAW ++ +L D ++ LL KH A
Sbjct: 383 LNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+++ ++ Q+L + + +AR ++ QW+ L AL ++R + L +
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
L ++ A W+ A+ + + H Q L H E+ ++
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH----EQFKA 556
Query: 799 HRPTLDALR-------------------EQAAALPPTLSRTPEVQGRVPTLERHYEEL-- 837
P D R A P T E+ G+ H +L
Sbjct: 557 TLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWD----HVRQLVP 612
Query: 838 ---QARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLA------LPERLEDLE 888
QA E AR ++A G W++ K + + ++ L ++L L
Sbjct: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLR 672
Query: 889 VVQQRFETLEPEMNTL 904
++ +P+++ L
Sbjct: 673 QYEKSIVNYKPKIDQL 688
Score = 45.1 bits (105), Expect = 9e-04
Identities = 95/442 (21%), Positives = 162/442 (36%), Gaps = 61/442 (13%)
Query: 1347 KPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANR--------AELFAQSCCALESW 1398
+P + D++ W LE + L + R AE F Q E+W
Sbjct: 350 RPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAW 409
Query: 1399 LESLQAQLHSDDY-GKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED--QG 1455
+ +A L DY L+ + LLKK + E ++A + VE I A A+ L + D
Sbjct: 410 TDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS 469
Query: 1456 AGEVERTSRAVE--EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTER-LPMAS 1512
R + + + AL Q RE R + E ++ L +R P +
Sbjct: 470 PSVNARCQKICDQWDNLGALTQKRREALERTEKLLE------TIDQLYLEYAKRAAPFNN 523
Query: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL----RERQRALGAAAAGPELAELQE 1568
ME + ++ + +Q HE A L +ER LG ++ +
Sbjct: 524 WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
Query: 1569 MWKRLGHE-------LELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL 1621
+ G E+ GK D +R RD A + E+ E+ + +
Sbjct: 584 V-NMAGTNPYTTITPQEINGK--WDHVRQLVPRRDQA-----LTEEHARQQHNERLRKQF 635
Query: 1622 SAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKE 1681
AQA V + + + + + ++ + +D + H I + ++D+L G +
Sbjct: 636 GAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQ 693
Query: 1682 LAGE-------RRERLQEHLR------LCQLRRELDDLEQWIQEREVVAASHELGQDYEH 1728
L E EH+R L + R ++++E I R+ S E ++
Sbjct: 694 LIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEF-- 751
Query: 1729 VTMLRDKFREFSRDTS-TIGQE 1749
R F F RD S T+G E
Sbjct: 752 ----RASFNHFDRDHSGTLGPE 769
Score = 39.3 bits (90), Expect = 0.047
Identities = 20/68 (29%), Positives = 40/68 (58%), Gaps = 4/68 (5%)
Query: 2018 FGRDAGMAEAWLCSQEPLVRSAELG-CTVDEVESLIKRHEAFQKSAVAWEERFCALEKLT 2076
F + A + EAW +E ++R + T+ E+++L+K+HEAF+ A ++R +E++
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDR---VEQIA 455
Query: 2077 ALEEREKE 2084
A+ + E
Sbjct: 456 AIAQELNE 463
Score = 37.7 bits (86), Expect = 0.14
Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 4/143 (2%)
Query: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRL-RDNREQQHFLQDCHELKLWID--E 1296
SEG + +D I +E+ K ++ + RL R + + F Q + W D E
Sbjct: 356 SEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 414
Query: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356
ML +D + +KH+AF ++LAA++D ++++ +EL V+
Sbjct: 415 AMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNA 474
Query: 1357 KLRDLHRRWDELETTTQAKARSL 1379
+ + + +WD L TQ + +L
Sbjct: 475 RCQKICDQWDNLGALTQKRREAL 497
Score = 35.0 bits (79), Expect = 0.88
Identities = 41/228 (17%), Positives = 85/228 (37%), Gaps = 20/228 (8%)
Query: 304 ERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKG 363
++L +Y A+ W+E + L D + +++ +Q + ++ +K
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD---ADKE 564
Query: 364 NLEVL-LFTIQSKL---------RANNQKVYTPREGRLISDINKAWERLEKAEHERELAL 413
L +L + SK+ N TP+E IN W+ + + R+ AL
Sbjct: 565 RLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQE------INGKWDHVRQLVPRRDQAL 618
Query: 414 RTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETD 473
E RQ+ E+L +F +A + W+ + + + + +E + E
Sbjct: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMH-GTLEDQLSHLRQYEKS 677
Query: 474 IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
IV Y ++ ++ + D K ++ W+ L +A
Sbjct: 678 IVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
Score = 31.6 bits (70), Expect = 9.8
Identities = 20/78 (25%), Positives = 39/78 (50%), Gaps = 2/78 (2%)
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L+ +AL ++H A+E D+ A +V+Q+ L + D + + Q + + W
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD-SPSVNARCQKICDQWDN 485
Query: 1892 LQGSSAARRQLLLDTTDK 1909
L G+ +R+ L+ T+K
Sbjct: 486 L-GALTQKRREALERTEK 502
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 427 bits (1098), Expect = e-119
Identities = 236/572 (41%), Positives = 343/572 (59%), Gaps = 30/572 (5%)
Query: 20 SDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVG 79
S N + P+ DWD D +E+ Q+KTFT W NSHL + ++
Sbjct: 6 SQQTNDYMQPEEDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIE 53
Query: 80 DLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSH 139
++ D RDG L+ LLEV+SGE L KP +G+MR+H + NV+KAL F+ + V L ++G+
Sbjct: 54 NIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE 113
Query: 140 DIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVH 199
+IVDGN ++TLG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVN+
Sbjct: 114 EIVDGNVKMTLGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNIQ 167
Query: 200 NFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED- 258
NF SW+DGL F A++H+HRP+L+D+ L+K + NL AF++AEK L + K+LD ED
Sbjct: 168 NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDI 227
Query: 259 VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318
V +PDEK+I+TYV+++YH FS + RI KVL E E+L+E YE LAS+LL
Sbjct: 228 VGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLL 287
Query: 319 QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378
+WI +TI L +R N++ +Q +L+ F YR + KPPK EK LE+ T+Q+KLR
Sbjct: 288 EWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL 347
Query: 379 NNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRE 438
+N+ + P EGR++SDIN AW LE+ E E L E+ R E+L+ LA +F +KA++ E
Sbjct: 348 SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE 407
Query: 439 TWLSENQRLVSQDNF-GLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYH 497
W + ++ Q ++ L+ ++A ++KHEA E+D+ A+ RV+ + A+A EL Y+
Sbjct: 408 AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYY 467
Query: 498 DIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL---------MDWME 548
D + AR + WD L + RRE L +L + D LYL +WME
Sbjct: 468 DSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETI-DQLYLEYAKRAAPFNNWME 526
Query: 549 EMKGRLQSQDLGRHLAGVEDLLQLHELVEADI 580
LQ + + ++ L HE +A +
Sbjct: 527 GAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL 558
Score = 56.2 bits (134), Expect = 4e-07
Identities = 96/465 (20%), Positives = 180/465 (38%), Gaps = 60/465 (12%)
Query: 1481 CRRLQASREQHQFHRDVED-----------EILWVTERLP------MASSMEHGKDLPSV 1523
C+ L ++E Q D E I W+ R+P M +E +D +
Sbjct: 263 CKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRL 322
Query: 1524 QLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRL-----GHELE 1578
K + Q EI + + LR R + G ++++ W L G+E
Sbjct: 323 HKPPKVQEKCQLEINFNTLQ-TKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEW 381
Query: 1579 LRG--KRLE--DALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEVKKHQVL 1633
L +RLE D L A++F + A+ EAW +E + ++ LS +A +KKH+
Sbjct: 382 LLNEIRRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEH 1693
E LA + + Q+AA +Q++ + ++ +S ++ R ++ + L L +RRE L+
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 1694 LRLCQLRREL--------DDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTST 1745
+L + +L W++ + E + L +F
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
Query: 1746 IGQERVD--SANALANGLIAGGHAARATVAEWK----DSLNEAWADLLELLDTRGQVLAA 1799
+ER+ + + ++ H A + +N W + +L+ R Q L
Sbjct: 561 ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTE 620
Query: 1800 AYELQRFLHGARQALAR--------VQHKQQQLPDGTGR---DLNAAEALQRRHCA-YEH 1847
+ Q+ R+ +Q K +++ GR +++ Q H YE
Sbjct: 621 EHARQQHNERLRKQFGAQANVIGPWIQTKMEEI----GRISIEMHGTLEDQLSHLRQYEK 676
Query: 1848 DIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
I P++ Q++ D +Q+A D + M+ + W QL
Sbjct: 677 SIVNYKPKIDQLEGDHQLIQEALIFDN-KHTNYTMEHIRVGWEQL 720
Score = 48.9 bits (115), Expect = 6e-05
Identities = 80/426 (18%), Positives = 158/426 (37%), Gaps = 61/426 (14%)
Query: 867 WVEEKEQWLNGLALPERLEDLE---------VVQQRFETLEPEMNTLAAQITAVNDIAEQ 917
W+E + A+ ++LED VQ++ + LE NTL ++ N A
Sbjct: 296 WLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQ-LEINFNTLQTKLRLSNRPAFM 354
Query: 918 LLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS--------IQNYHLECTE 969
P + R+V+ +N+ W ++ G + L + + + + + +
Sbjct: 355 ------PSEGRMVS---DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASI 405
Query: 970 TQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGH 1029
+AW K ++ L+ + AL +K E DL A RV ++ A L
Sbjct: 406 HEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELD 465
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRL--------QDFLRSLDDFQAWL 1081
+ ++NAR +++ W++L A ++R E+L +L ++ + F W+
Sbjct: 466 YYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWM 525
Query: 1082 GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR-------- 1133
+ T+ E + L H + + A E + + EV++
Sbjct: 526 EGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVN 585
Query: 1134 -DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSS-- 1190
+P Q + W+ + ++ R L + H Q R+ G ++
Sbjct: 586 MAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVI 642
Query: 1191 --------QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG 1242
+E EM GTL+ + +++ E + ++ LE QL+ E
Sbjct: 643 GPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQ----LEGDHQLIQEA 698
Query: 1243 NIHADK 1248
I +K
Sbjct: 699 LIFDNK 704
Score = 47.4 bits (111), Expect = 2e-04
Identities = 82/436 (18%), Positives = 158/436 (36%), Gaps = 60/436 (13%)
Query: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
+++A +E L + +K+ DLL + W+E + + L D +LH
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSER------VAKLEQSYEALC 627
+ + Q E + LR N + P + ++VS+ + ++E+ YE
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNR-PAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382
Query: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR-LLNKHTAL 686
R RL+ +F + EAW ++ +L D ++ LL KH A
Sbjct: 383 LNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+++ ++ Q+L + + +AR ++ QW+ L AL ++R + L +
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
L ++ A W+ A+ + + H Q L H E+ ++
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAH----EQFKA 556
Query: 799 HRPTLDALR-------------------EQAAALPPTLSRTPEVQGRVPTLERHYEEL-- 837
P D R A P T E+ G+ H +L
Sbjct: 557 TLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWD----HVRQLVP 612
Query: 838 ---QARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLA------LPERLEDLE 888
QA E AR ++A G W++ K + + ++ L ++L L
Sbjct: 613 RRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLR 672
Query: 889 VVQQRFETLEPEMNTL 904
++ +P+++ L
Sbjct: 673 QYEKSIVNYKPKIDQL 688
Score = 45.1 bits (105), Expect = 9e-04
Identities = 95/442 (21%), Positives = 162/442 (36%), Gaps = 61/442 (13%)
Query: 1347 KPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANR--------AELFAQSCCALESW 1398
+P + D++ W LE + L + R AE F Q E+W
Sbjct: 350 RPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAW 409
Query: 1399 LESLQAQLHSDDY-GKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED--QG 1455
+ +A L DY L+ + LLKK + E ++A + VE I A A+ L + D
Sbjct: 410 TDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS 469
Query: 1456 AGEVERTSRAVE--EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTER-LPMAS 1512
R + + + AL Q RE R + E ++ L +R P +
Sbjct: 470 PSVNARCQKICDQWDNLGALTQKRREALERTEKLLE------TIDQLYLEYAKRAAPFNN 523
Query: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL----RERQRALGAAAAGPELAELQE 1568
ME + ++ + +Q HE A L +ER LG ++ +
Sbjct: 524 WMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH 583
Query: 1569 MWKRLGHE-------LELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL 1621
+ G E+ GK D +R RD A + E+ E+ + +
Sbjct: 584 V-NMAGTNPYTTITPQEINGK--WDHVRQLVPRRDQA-----LTEEHARQQHNERLRKQF 635
Query: 1622 SAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKE 1681
AQA V + + + + + ++ + +D + H I + ++D+L G +
Sbjct: 636 GAQANVIGPWI-QTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQ 693
Query: 1682 LAGE-------RRERLQEHLR------LCQLRRELDDLEQWIQEREVVAASHELGQDYEH 1728
L E EH+R L + R ++++E I R+ S E ++
Sbjct: 694 LIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEF-- 751
Query: 1729 VTMLRDKFREFSRDTS-TIGQE 1749
R F F RD S T+G E
Sbjct: 752 ----RASFNHFDRDHSGTLGPE 769
Score = 39.3 bits (90), Expect = 0.047
Identities = 20/68 (29%), Positives = 40/68 (58%), Gaps = 4/68 (5%)
Query: 2018 FGRDAGMAEAWLCSQEPLVRSAELG-CTVDEVESLIKRHEAFQKSAVAWEERFCALEKLT 2076
F + A + EAW +E ++R + T+ E+++L+K+HEAF+ A ++R +E++
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDR---VEQIA 455
Query: 2077 ALEEREKE 2084
A+ + E
Sbjct: 456 AIAQELNE 463
Score = 37.7 bits (86), Expect = 0.14
Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 4/143 (2%)
Query: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRL-RDNREQQHFLQDCHELKLWID--E 1296
SEG + +D I +E+ K ++ + RL R + + F Q + W D E
Sbjct: 356 SEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 414
Query: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356
ML +D + +KH+AF ++LAA++D ++++ +EL V+
Sbjct: 415 AMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNA 474
Query: 1357 KLRDLHRRWDELETTTQAKARSL 1379
+ + + +WD L TQ + +L
Sbjct: 475 RCQKICDQWDNLGALTQKRREAL 497
Score = 35.0 bits (79), Expect = 0.88
Identities = 41/228 (17%), Positives = 85/228 (37%), Gaps = 20/228 (8%)
Query: 304 ERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKG 363
++L +Y A+ W+E + L D + +++ +Q + ++ +K
Sbjct: 508 DQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD---ADKE 564
Query: 364 NLEVL-LFTIQSKL---------RANNQKVYTPREGRLISDINKAWERLEKAEHERELAL 413
L +L + SK+ N TP+E IN W+ + + R+ AL
Sbjct: 565 RLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQE------INGKWDHVRQLVPRRDQAL 618
Query: 414 RTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETD 473
E RQ+ E+L +F +A + W+ + + + + +E + E
Sbjct: 619 TEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMH-GTLEDQLSHLRQYEKS 677
Query: 474 IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
IV Y ++ ++ + D K ++ W+ L +A
Sbjct: 678 IVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
Score = 31.6 bits (70), Expect = 9.8
Identities = 20/78 (25%), Positives = 39/78 (50%), Gaps = 2/78 (2%)
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L+ +AL ++H A+E D+ A +V+Q+ L + D + + Q + + W
Sbjct: 427 LSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD-SPSVNARCQKICDQWDN 485
Query: 1892 LQGSSAARRQLLLDTTDK 1909
L G+ +R+ L+ T+K
Sbjct: 486 L-GALTQKRREALERTEK 502
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 427 bits (1097), Expect = e-119
Identities = 551/2242 (24%), Positives = 905/2242 (40%), Gaps = 310/2242 (13%)
Query: 53 DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112
DER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP+ KGRMR
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96
Query: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V +
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155
Query: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232
E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D + +
Sbjct: 156 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214
Query: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292
NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++ + +G R
Sbjct: 215 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273
Query: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352
A E + ++Y L LLQW+ +R+ +S ++ F ++
Sbjct: 274 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326
Query: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 327 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 383
Query: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472
LR+E R E L+++ + +A + E L++ L+ D + L A ++ +E
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440
Query: 473 D-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRE 525
D I VQ + + Y + R+ R + ++ + A
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500
Query: 526 RLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLL----Q 571
+ + LQ V + L YL D W+EE + R+ + G L VE L
Sbjct: 501 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 560
Query: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
LH+ +E + + ER R+ L G YR C + +L+ Y +L
Sbjct: 561 LHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY---AKLLN 606
Query: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
+ +ARL L F+ + W+ E++ D T ++AL E+
Sbjct: 607 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 666
Query: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
+ +K G +L+ E HP + A LQ QW + L L + A+ +Q
Sbjct: 667 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 726
Query: 752 FQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALRE 808
F +D + E L +ALR S + + L + + +E++ ++ L L +
Sbjct: 727 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 786
Query: 809 QAAALPPTLSRTP--EVQGRVPTL-------------------------ERHYEELQARA 841
+A A+ R P ++GR+P L H++ L +
Sbjct: 787 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG 846
Query: 842 GERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888
E A A EA L LW + + LA D++
Sbjct: 847 SEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAWQSLRRDVQ 904
Query: 889 VVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE--QLNHR 939
+++ F TL+PE A ++ A + G +DR++ +E +H
Sbjct: 905 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 964
Query: 940 WQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------------ 975
+QQ + L G + S L LE ET+ R
Sbjct: 965 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1024
Query: 976 EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANALAAGH 1029
E+ K +GLG +A + A K+ A EL + +L+A +
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1084
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVA 1089
+ I+ +R Q E LRA EE L EA+ +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV---------------------- 1118
Query: 1090 SEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQADPQC 1140
PATLPE EA A LR + E Q + LR +GE + + + D +
Sbjct: 1119 ----PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174
Query: 1141 LFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDARQAEGVLS 1189
R+R+ L W+ + + RQ L Q A +L+DAR+ + +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 1190 SQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS-----EGNI 1244
+ S QA +++ + + ++ +GE++ +Q ++ E +
Sbjct: 1235 AMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1286
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDCHELKLWID 1295
K + + + + K Q ++ + D R Q+ L+ +
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 1296 EKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE-----------GRE 1342
E+ L Q + + R + +K + A K ++ KE E
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402
++ + K + E+L+ L + E QAKAR A R+ L + E + L
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE----EIRVVRL 1459
Query: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERT 1462
Q + G + L + + E + ++E E ++ Q + +Q + A EVE
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELA 1518
Query: 1463 SR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEH 1516
SR A EK RAL Q + E RLQA + + + + V L A
Sbjct: 1519 SRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE 1576
+ +K L++ +Q +A LRE A + AE + + E
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAERAREEAERE 1630
Query: 1577 LELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK 1628
LE + +ALR AQQ AEAE E E + KA+++ Q E+
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690
Query: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688
+ Q LE+ T Q A+ Q++I R+ Q GE++
Sbjct: 1691 E-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ------------GEQQR 1729
Query: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748
+L E L +L+RE Q QE E A ++ + E + + + E SR TS +
Sbjct: 1730 QLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQVLAAAYELQ 1804
+R+++ L RA E K A D E + LAA E
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 1805 RFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQALSPQVQQV 1859
R A AL + + ++L R L EA QRR ++ DI+ Q+++
Sbjct: 1847 RLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TTDKFRF 1912
D QK D + + + + A + ++A + +L L+ D R
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 1913 -----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE----IEARADRF 1963
+A R+ L +E + +A+ER + +A+ Q+ E ++A+ +
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1964 SSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQLVLEVLVF 2018
+ ++ AR A+E ++K Q + + Q+ ++ Q+ + Q VL+ L
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL 2078
+A A + + E + +VE + ++ ++ A A + A EKL
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 2079 EEREKERKRKREEEERRKQPPA 2100
E+E R+ + E+ R++ A
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAA 2163
Score = 123 bits (309), Expect = 2e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 1166 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225
Query: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 1226 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1402
Query: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 1403 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1447
Query: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 1448 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1549
Query: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609
Query: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1661
Query: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 1662 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1711
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 1712 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1759
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1818
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1874
Query: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 1875 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1914
Query: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 1915 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 2035 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2081
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2489
Query: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2669
Query: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 2670 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2725
Query: 1926 VNLQMDAQ 1933
+ ++AQ
Sbjct: 2726 ALILLEAQ 2733
Score = 122 bits (307), Expect = 3e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 1244 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
K++ E++ + R E L Q++ ++T R +
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1347
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 1348 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 1404 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 1514 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1557
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
+ L A + + + + + Q R + A+ + +
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 1618 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1730
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1786
Query: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1842
Query: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1843 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1890
Query: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 1891 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1933
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 1934 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 1990 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 2164 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2215
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2272
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 2273 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2322
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 2323 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2376
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 2377 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2429
Query: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2483
Query: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 2484 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2536
Query: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 2537 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 2009 LQLVLEVLVFGRDAGMAEA 2027
L+ L++L A +A +
Sbjct: 2594 LREQLQLLEEQHRAALAHS 2612
Score = 117 bits (293), Expect = 1e-25
Identities = 364/1690 (21%), Positives = 633/1690 (37%), Gaps = 277/1690 (16%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
+E++ E ++ +Q I + D +L L + QL+ S K PK + G+
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYEL--QLVTYKAQLEPVAS---PAKKPK-VQSGSES 1311
Query: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
V+ + + + T + + IS E L + E E LA + +E+L ++
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFIS------ETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
A +++ + E ++ + ++ L+ E VR+ EA AVDA
Sbjct: 1366 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEA-------------AVDA 1411
Query: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
+ + + +++++ RQ + A + RQ AA R RL + E++ V
Sbjct: 1412 QQQKRSIQE--ELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV---------- 1457
Query: 547 MEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRP 606
RLQ + R G E LQ A R RA A A + ++ +
Sbjct: 1458 ------RLQLEATERQRGGAEGELQ------------ALRARAEEAEAQK-----RQAQE 1494
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLAS 666
+L + + ++ +A ELA+ +A E +R R L + E E + L
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQA---SARAA 723
A+ R + L + E+ + Q ++ + E H +Q + R A
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 724 ELQAQWERLEALAE---ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
+ QA+ ER AE ER Q A A + QA+ + L A E +
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 781 ----STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSR----TPEVQGRVPTLER 832
+ + RQ E+E+ R + +Q A L R T + + + LE
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734
Query: 833 HYEELQ---ARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEV 889
LQ A A ++ + LEA LA E E+E +RLE
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE---A 1791
Query: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
RF L E AA++ A+ + A+ + R + ++ R + R LA+
Sbjct: 1792 EAGRFRELAEE----AARLRALAEEAK---------RQRQLAEEDAARQRAEAERVLAE- 1837
Query: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLA-LQRKLAGTERDL 1008
K AA+ A ++ TE + ++EK E + L D A L+ + A + D+
Sbjct: 1838 KLAAIGEATRLK------TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 1009 EAIAARV-----GELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE 1063
E A++ EL R+ L Q + + ++ +E A E LG
Sbjct: 1892 EERLAQLRKASDSELERQ-KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 1064 AR-RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVER----AQ 1118
R +D LRS + + R + A EE EAE + + A E R A
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAARQRKAAL 2008
Query: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLA---QAHGFQ 1175
E RL+A EE R LR+R E +L + E+ Q RL +AH F
Sbjct: 2009 EEVERLKAKVEEARR---------LRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF- 2056
Query: 1176 GFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG---------- 1225
+ ++ + L ++ VL ++ G +AA A ++ E+ +
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114
Query: 1226 ERIHGLLEAGRQLVSEGNIHADKIREKADS-IERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
ER+ E Q ++ A+K+R++A+ RR + Q A +Q + + + F
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 1285 QDCHELKLWIDEKMLTA--QDVSYDEARNL-HTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
+ K +++++ T Q D +NL + Q+ +A E A + +++ R
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 1342 ELTLEKPELKALVSEK-----LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
E +LKA + + LRD L+ + + +A R + AQ L
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA 1456
QL +D + +LK++ E + E E +Q Q K LAQE
Sbjct: 2295 --------QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQE---- 2341
Query: 1457 GEVERTSRAVEEKFRALCQPMRERCRRLQASRE-QHQFHRDVEDEILWVTERLPMASSME 1515
+ R E+ + L + + R L+A R+ Q + + E L V E + E
Sbjct: 2342 -QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 1516 H------------GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL 1563
G+ L +L ++ TL + ++ ++ +Q A +
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------IQRQQSDHDAERLREAI 2452
Query: 1564 AELQEMWKRLGHE---LELRGKRLEDALRAQQFYRDAAEAEAWMGE-----QELHMMGQE 1615
AEL+ ++L E L+L+ + ++ + Q A ++++ E Q + QE
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQ----LAASSQDMIDHEHP----------E 1661
KAK E Q EV K Q L + Q + Q L AS ++ +H E
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE------------------- 1702
++ ++ Q ++L A + E+ + L+E R E
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA 2632
Query: 1703 -------------LDDLE-----QWIQEREVVAASH--ELGQDYEHVTML--RDKFREFS 1740
D L Q +QE +++A L Q + V L R+ R +
Sbjct: 2633 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2692
Query: 1741 RDTSTIG-------QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
+ S+I E++ AL L++ G A A+ A LL+ + R
Sbjct: 2693 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ------AASGFLLDPVRNR 2746
Query: 1794 GQVLAAAY-------ELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYE 1846
+ A EL L A +A+ + TG+ ++ +A+Q+ E
Sbjct: 2747 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPY------TGQQISLFQAMQKGLIVRE 2800
Query: 1847 HDIQALSPQV 1856
H I+ L Q+
Sbjct: 2801 HGIRLLEAQI 2810
Score = 115 bits (288), Expect = 5e-25
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 1148 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1203
Query: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 1204 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1262
Query: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 1323 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1372
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
A A + + ++ +V +E QQ R + + + S S
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1430
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1487
Query: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1546
Query: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1847 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2063
Query: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 2184 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2236
Query: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 2237 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2278
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
AAR +VA Q A +L ++ALA ++ K
Sbjct: 2279 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2364
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 2365 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2418
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2464
Query: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2519
Query: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Score = 106 bits (264), Expect = 3e-22
Identities = 327/1505 (21%), Positives = 556/1505 (36%), Gaps = 274/1505 (18%)
Query: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 1365 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1413
Query: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
QK R I QE+L+QL ++ + +A R+
Sbjct: 1414 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1439
Query: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1492
Query: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1547
Query: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
R L E + + +A++ + A + + + ++ + L E VA
Sbjct: 1548 AERRLRQAE----VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 619 LEQSYEA---LCELAAARRARLEESRRLWRFLWEVGEA-----EAWVREQQHLLASADTG 670
+ EA + A A RAR E R L R+ + EA +A QQ LA A+
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 671 RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL-QAQW 729
+ A R + RG+ A + + R EL + +
Sbjct: 1664 KQKEEAEREARR----RGK-------------------------AEEQAVRQRELAEQEL 1694
Query: 730 ERLEALAEERA-QRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
E+ LAE A QRLA L + +A+ E R + EL + A ++
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGE-----QQRQLLEEELARLQREAAAATQK 1749
Query: 789 HRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARAL 848
+ LE E+ R ++ L A E + R T E+ + L+A AG
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKA--------RAEEESR-STSEKSKQRLEAEAGRFRELA 1800
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E A L + EA K Q +L + + +QR E LA ++
Sbjct: 1801 EEAARLRALAEEA---------KRQ--------RQLAEEDAARQRAEA----ERVLAEKL 1839
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
A+ + +A K++ E N R RRLA
Sbjct: 1840 AAIGEATRLKTEAEIALKEK-----EAENER---LRRLA--------------------- 1870
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E +A+ R + + E D+ LA RK + +E LE V + R+ +
Sbjct: 1871 EDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQV--- 1923
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTA 1087
+ +A+ A + G +L E LG R +D LRS + + R +
Sbjct: 1924 -EEEILALKASFEKAAAGKAEL-------ELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFL 1143
A EE EAE + + A E R A E RL+A EE R L
Sbjct: 1976 AAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------L 2024
Query: 1144 RQRLEALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
R+R E +L + E+ Q RL +AH F + ++ + L ++ VL ++
Sbjct: 2025 RERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QL 2079
Query: 1201 PGTLQAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIR 1250
G +AA A ++ E+ + ER+ E Q ++ A+K+R
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 1251 EKAD-SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYD 1307
++A+ RR + Q A +Q + + + F + K +++++ T Q D
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 1308 EARN-LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDL 1361
+N L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259
Query: 1362 HRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNIL 1421
L+ + + +A R + AQ L QL +D + +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKM 2311
Query: 1422 LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERC 1481
LK++ E + E E +Q Q K LAQE + R E+ + L + +
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQ 2365
Query: 1482 RRLQASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMK 1528
R L+A R+ Q + + E L V E + E G+ L +L +
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLE 1585
+ TL + + +++ +Q A +AEL+ ++L E L+L+ + ++
Sbjct: 2426 EKVTLVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 1586 DALRAQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
+ Q A ++++ E Q + QEKAK E Q EV K Q L +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537
Query: 1641 AQTIHQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEH 1693
Q + Q L AS ++ +H + +Q ++ +L + EL E +RL+E
Sbjct: 2538 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Query: 1694 LRLCQ 1698
L+L +
Sbjct: 2598 LQLLE 2602
Score = 96.7 bits (239), Expect = 2e-19
Identities = 353/1719 (20%), Positives = 645/1719 (37%), Gaps = 237/1719 (13%)
Query: 529 LNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLL-QLHELVEADI-AVQAER 586
L L Q+ + +L L+ WM + + +E L Q + E ++ A +A++
Sbjct: 277 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 336
Query: 587 VR----------AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
R AV A L+ PG Y P D V + KL + A+ E R+
Sbjct: 337 NRSKGIYQSLEGAVQAGQLKV-PPG--YHPLD---VEKEWGKL---HVAILEREKQLRSE 387
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRD--LTGALRLLNKHTALRGEMSGRL 694
E L R + ++ + EA + E+Q A A D L A ++ + + ++
Sbjct: 388 FERLECLQRIVTKL-QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 446
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL-----AQAASL 749
++L Q L HP Q R L ERL A+ E RL A A +
Sbjct: 447 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH---ERLVAIRTEYNLRLKAGVAAPATQV 503
Query: 750 YQFQADA---------------NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEE 794
Q + D+ AW+ + V E G D S +A HR L +
Sbjct: 504 AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 563
Query: 795 EIRSHRPTLDALREQAAALPP-TLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
I R ++ R L P T + GR L+ Y +L + R R+LE+
Sbjct: 564 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGR---LDLQYAKLLNSSKARLRSLES--- 617
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVND 913
L++ ++ A +W+ EKE+ G +R ++ ++ + L E+ +I + +
Sbjct: 618 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 677
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++LL+ + P + + + Q L +W +L +A L + + + E +
Sbjct: 678 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQ 737
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT---REANA---LAA 1027
+++ + + A V L+ L + + E + G L+ + A A L
Sbjct: 738 LQKLQEALRRKYSCDRS-ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 796
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREES--LGEARRLQDFLRSLDDFQAWLGRTQ 1085
HPA + L V ++ + T+ + +E +G A+ + S +A
Sbjct: 797 RHPAHPMRGRLPLLAV-CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA------ 849
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AV S P EA A V R ++++ L L ++ D +
Sbjct: 850 -AVPSVCFLVPPPNQEAQEA--------VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 900
Query: 1146 RLEALGTGWE----ELGRMWESRQGRLAQAHGFQGFLRDARQAEG------VLSSQEYVL 1195
R L W + E RQ + +Q FLRD++ A G +++ +EY
Sbjct: 901 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 960
Query: 1196 SHTEMPGTLQAADAA----------IKKLEDFMSTMDANGER-IHGLLEAGRQLVSEGNI 1244
LQ+ + I +L+D ++A R +H L +
Sbjct: 961 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP---------L 1011
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL------------QDCHELKL 1292
+ RE A I + K + G R + E + L + EL L
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 1293 WIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E++ + + ++ + + + Q L A+++ L KE + + PEL+A
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLPELEA 1127
Query: 1353 LVS--EKLRDLHRRWDELETTTQAKARS-LFDANRAELFAQSCCALESWLESLQAQLHSD 1409
+ +KLR QA+A+ FDA R EL E LQ +
Sbjct: 1128 TKASLKKLR------------AQAEAQQPTFDALRDELRGAQEVG-----ERLQQRHGER 1170
Query: 1410 DYGKDLTSVNI--LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVE 1467
D + + LL++ Q + + VR++E+E + Q + + G + +R +
Sbjct: 1171 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230
Query: 1468 EKFRAL----CQPMRERCRRLQASREQHQFHRDVEDE-------------------ILWV 1504
E+ +A+ Q +RE+ R+ QA E+ + H + +E + +
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290
Query: 1505 TERLPMASSME--------------------HGKDLPSV--QLLMKKNQTLQKEIQGHEP 1542
+ P+AS + H +L ++ Q + ++TL++ E
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR--MEEEE 1348
Query: 1543 RIADLR---ERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
R+A+ + ER+R AA + +L E + + E K L+ ++ + R+ A
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 1600 AEAWMGEQELHM-MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
+A ++ + + Q + E QA+ ++ + E++ + I + + E
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR------LQLE 1462
Query: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
E R + ++ L A +E ++R+ +E RL RR++ D Q ++ EV A
Sbjct: 1463 ATERQRGGA-EGELQALRARAEEAEAQKRQAQEEAERL---RRQVQDESQRKRQAEVELA 1518
Query: 1719 SH-----ELGQDYEHVTMLRDKFREFSRDTST-IGQERVDSANALANGLIAGGHAARATV 1772
S E ++ + ++ R + + + Q V+ A + L +A A +
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 1773 AEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR-D 1831
+ S E A L L +A +L+ Q A + +++ R
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L A EAL+ R A E Q Q + + ++A KAEE + +AE +
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 1892 LQGSSA-ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Q A Q L + +A E E Q+ +E R A + +Q
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETE----QGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 1951 GIKAEI-EARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++AE+ + RA+ E+L S AEE S S+ +R E ++
Sbjct: 1752 ELEAELAKVRAEM---------EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA-VAWEER 2068
L L + + L ++ + AE + E + I + A +A +E+
Sbjct: 1803 AARLRALA---EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 2069 FCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASV 2107
E+L L E E ++R+ EE+ + + E A +
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Score = 77.4 bits (189), Expect = 2e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 973 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1030
Query: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 1031 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1084
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1205 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1316
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1317 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1373
Query: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1420
Query: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1421 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1475
Query: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1534
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1535 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1587
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1588 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1634
Query: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
+ ++ + Q++ +LA AE + EA +
Sbjct: 1635 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1675
Query: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1676 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1726 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1897
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 1898 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 427 bits (1097), Expect = e-119
Identities = 551/2242 (24%), Positives = 905/2242 (40%), Gaps = 310/2242 (13%)
Query: 53 DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112
DER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP+ KGRMR
Sbjct: 42 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 100
Query: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V +
Sbjct: 101 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 159
Query: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232
E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D + +
Sbjct: 160 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 218
Query: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292
NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++ + +G R
Sbjct: 219 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 277
Query: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352
A E + ++Y L LLQW+ +R+ +S ++ F ++
Sbjct: 278 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 330
Query: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 331 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 387
Query: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472
LR+E R E L+++ + +A + E L++ L+ D + L A ++ +E
Sbjct: 388 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 444
Query: 473 D-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRE 525
D I VQ + + Y + R+ R + ++ + A
Sbjct: 445 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 504
Query: 526 RLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLL----Q 571
+ + LQ V + L YL D W+EE + R+ + G L VE L
Sbjct: 505 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 564
Query: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
LH+ +E + + ER R+ L G YR C + +L+ Y +L
Sbjct: 565 LHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY---AKLLN 610
Query: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
+ +ARL L F+ + W+ E++ D T ++AL E+
Sbjct: 611 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 670
Query: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
+ +K G +L+ E HP + A LQ QW + L L + A+ +Q
Sbjct: 671 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 730
Query: 752 FQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALRE 808
F +D + E L +ALR S + + L + + +E++ ++ L L +
Sbjct: 731 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 790
Query: 809 QAAALPPTLSRTP--EVQGRVPTL-------------------------ERHYEELQARA 841
+A A+ R P ++GR+P L H++ L +
Sbjct: 791 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG 850
Query: 842 GERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888
E A A EA L LW + + LA D++
Sbjct: 851 SEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAWQSLRRDVQ 908
Query: 889 VVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE--QLNHR 939
+++ F TL+PE A ++ A + G +DR++ +E +H
Sbjct: 909 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 968
Query: 940 WQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------------ 975
+QQ + L G + S L LE ET+ R
Sbjct: 969 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1028
Query: 976 EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANALAAGH 1029
E+ K +GLG +A + A K+ A EL + +L+A +
Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1088
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVA 1089
+ I+ +R Q E LRA EE L EA+ +
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV---------------------- 1122
Query: 1090 SEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQADPQC 1140
PATLPE EA A LR + E Q + LR +GE + + + D +
Sbjct: 1123 ----PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1178
Query: 1141 LFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDARQAEGVLS 1189
R+R+ L W+ + + RQ L Q A +L+DAR+ + +
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238
Query: 1190 SQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS-----EGNI 1244
+ S QA +++ + + ++ +GE++ +Q ++ E +
Sbjct: 1239 AMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1290
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDCHELKLWID 1295
K + + + + K Q ++ + D R Q+ L+ +
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1350
Query: 1296 EKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE-----------GRE 1342
E+ L Q + + R + +K + A K ++ KE E
Sbjct: 1351 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410
Query: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402
++ + K + E+L+ L + E QAKAR A R+ L + E + L
Sbjct: 1411 AAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE----EIRVVRL 1463
Query: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERT 1462
Q + G + L + + E + ++E E ++ Q + +Q + A EVE
Sbjct: 1464 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELA 1522
Query: 1463 SR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEH 1516
SR A EK RAL Q + E RLQA + + + + V L A
Sbjct: 1523 SRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE 1576
+ +K L++ +Q +A LRE A + AE + + E
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAERAREEAERE 1634
Query: 1577 LELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK 1628
LE + +ALR AQQ AEAE E E + KA+++ Q E+
Sbjct: 1635 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1694
Query: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688
+ Q LE+ T Q A+ Q++I R+ Q GE++
Sbjct: 1695 E-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ------------GEQQR 1733
Query: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748
+L E L +L+RE Q QE E A ++ + E + + + E SR TS +
Sbjct: 1734 QLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQVLAAAYELQ 1804
+R+++ L RA E K A D E + LAA E
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 1805 RFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQALSPQVQQV 1859
R A AL + + ++L R L EA QRR ++ DI+ Q+++
Sbjct: 1851 RLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TTDKFRF 1912
D QK D + + + + A + ++A + +L L+ D R
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 1913 -----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE----IEARADRF 1963
+A R+ L +E + +A+ER + +A+ Q+ E ++A+ +
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 1964 SSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQLVLEVLVF 2018
+ ++ AR A+E ++K Q + + Q+ ++ Q+ + Q VL+ L
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2085
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL 2078
+A A + + E + +VE + ++ ++ A A + A EKL
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 2079 EEREKERKRKREEEERRKQPPA 2100
E+E R+ + E+ R++ A
Sbjct: 2146 AEQEAARRAQAEQAALRQKQAA 2167
Score = 123 bits (309), Expect = 2e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 1170 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1229
Query: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 1230 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1288
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1406
Query: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 1407 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1451
Query: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 1452 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1503
Query: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 1504 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1553
Query: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1613
Query: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1665
Query: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 1666 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1715
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 1716 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1763
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1822
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1823 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1878
Query: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 1879 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1918
Query: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 1919 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1978
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 1979 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2038
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 2039 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2085
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2139
Query: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199
Query: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2317
Query: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2493
Query: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2613
Query: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 2614 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2673
Query: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 2674 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2729
Query: 1926 VNLQMDAQ 1933
+ ++AQ
Sbjct: 2730 ALILLEAQ 2737
Score = 122 bits (307), Expect = 3e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1187
Query: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 1188 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1247
Query: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 1248 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1306
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
K++ E++ + R E L Q++ ++T R +
Sbjct: 1307 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1351
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 1352 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 1408 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
Query: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 1458 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 1518 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1561
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
+ L A + + + + + Q R + A+ + +
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1621
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 1622 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1734
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1790
Query: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1846
Query: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1847 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1894
Query: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 1895 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1937
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 1938 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 1994 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2107
Query: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167
Query: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 2168 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2219
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2276
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 2277 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2326
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 2327 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2380
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 2381 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2433
Query: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 2434 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2487
Query: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 2488 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2540
Query: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 2541 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597
Query: 2009 LQLVLEVLVFGRDAGMAEA 2027
L+ L++L A +A +
Sbjct: 2598 LREQLQLLEEQHRAALAHS 2616
Score = 117 bits (293), Expect = 1e-25
Identities = 364/1690 (21%), Positives = 633/1690 (37%), Gaps = 277/1690 (16%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
+E++ E ++ +Q I + D +L L + QL+ S K PK + G+
Sbjct: 1262 IERHGEKVEECQRFAKQYINAIKDYEL--QLVTYKAQLEPVAS---PAKKPK-VQSGSES 1315
Query: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
V+ + + + T + + IS E L + E E LA + +E+L ++
Sbjct: 1316 VIQEYVDLRTHYSELTTLTSQYIKFIS------ETLRRMEEEERLAEQQRAEERERLAEV 1369
Query: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
A +++ + E ++ + ++ L+ E VR+ EA AVDA
Sbjct: 1370 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEA-------------AVDA 1415
Query: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
+ + + +++++ RQ + A + RQ AA R RL + E++ V
Sbjct: 1416 QQQKRSIQE--ELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV---------- 1461
Query: 547 MEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRP 606
RLQ + R G E LQ A R RA A A + ++ +
Sbjct: 1462 ------RLQLEATERQRGGAEGELQ------------ALRARAEEAEAQK-----RQAQE 1498
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLAS 666
+L + + ++ +A ELA+ +A E +R R L + E E + L
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1558
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQA---SARAA 723
A+ R + L + E+ + Q ++ + E H +Q + R A
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1618
Query: 724 ELQAQWERLEALAE---ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
+ QA+ ER AE ER Q A A + QA+ + L A E +
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1678
Query: 781 ----STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSR----TPEVQGRVPTLER 832
+ + RQ E+E+ R + +Q A L R T + + + LE
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1738
Query: 833 HYEELQ---ARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEV 889
LQ A A ++ + LEA LA E E+E +RLE
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE---A 1795
Query: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
RF L E AA++ A+ + A+ + R + ++ R + R LA+
Sbjct: 1796 EAGRFRELAEE----AARLRALAEEAK---------RQRQLAEEDAARQRAEAERVLAE- 1841
Query: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLA-LQRKLAGTERDL 1008
K AA+ A ++ TE + ++EK E + L D A L+ + A + D+
Sbjct: 1842 KLAAIGEATRLK------TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895
Query: 1009 EAIAARV-----GELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE 1063
E A++ EL R+ L Q + + ++ +E A E LG
Sbjct: 1896 EERLAQLRKASDSELERQ-KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Query: 1064 AR-RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVER----AQ 1118
R +D LRS + + R + A EE EAE + + A E R A
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAARQRKAAL 2012
Query: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLA---QAHGFQ 1175
E RL+A EE R LR+R E +L + E+ Q RL +AH F
Sbjct: 2013 EEVERLKAKVEEARR---------LRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF- 2060
Query: 1176 GFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG---------- 1225
+ ++ + L ++ VL ++ G +AA A ++ E+ +
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2118
Query: 1226 ERIHGLLEAGRQLVSEGNIHADKIREKADS-IERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
ER+ E Q ++ A+K+R++A+ RR + Q A +Q + + + F
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178
Query: 1285 QDCHELKLWIDEKMLTA--QDVSYDEARNL-HTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
+ K +++++ T Q D +NL + Q+ +A E A + +++ R
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 1342 ELTLEKPELKALVSEK-----LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
E +LKA + + LRD L+ + + +A R + AQ L
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA 1456
QL +D + +LK++ E + E E +Q Q K LAQE
Sbjct: 2299 --------QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQE---- 2345
Query: 1457 GEVERTSRAVEEKFRALCQPMRERCRRLQASRE-QHQFHRDVEDEILWVTERLPMASSME 1515
+ R E+ + L + + R L+A R+ Q + + E L V E + E
Sbjct: 2346 -QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2404
Query: 1516 H------------GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL 1563
G+ L +L ++ TL + ++ ++ +Q A +
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------IQRQQSDHDAERLREAI 2456
Query: 1564 AELQEMWKRLGHE---LELRGKRLEDALRAQQFYRDAAEAEAWMGE-----QELHMMGQE 1615
AEL+ ++L E L+L+ + ++ + Q A ++++ E Q + QE
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2516
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQ----LAASSQDMIDHEHP----------E 1661
KAK E Q EV K Q L + Q + Q L AS ++ +H E
Sbjct: 2517 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2576
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE------------------- 1702
++ ++ Q ++L A + E+ + L+E R E
Sbjct: 2577 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA 2636
Query: 1703 -------------LDDLE-----QWIQEREVVAASH--ELGQDYEHVTML--RDKFREFS 1740
D L Q +QE +++A L Q + V L R+ R +
Sbjct: 2637 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2696
Query: 1741 RDTSTIG-------QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
+ S+I E++ AL L++ G A A+ A LL+ + R
Sbjct: 2697 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ------AASGFLLDPVRNR 2750
Query: 1794 GQVLAAAY-------ELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYE 1846
+ A EL L A +A+ + TG+ ++ +A+Q+ E
Sbjct: 2751 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPY------TGQQISLFQAMQKGLIVRE 2804
Query: 1847 HDIQALSPQV 1856
H I+ L Q+
Sbjct: 2805 HGIRLLEAQI 2814
Score = 115 bits (288), Expect = 5e-25
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 1152 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1207
Query: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 1208 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1266
Query: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 1327 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1376
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
A A + + ++ +V +E QQ R + + + S S
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1434
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 1435 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1491
Query: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1550
Query: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1851 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967
Query: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027
Query: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2067
Query: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127
Query: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2187
Query: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 2188 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2240
Query: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 2241 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2282
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
AAR +VA Q A +L ++ALA ++ K
Sbjct: 2283 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2319
Query: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2368
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 2369 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2422
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 2423 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2468
Query: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2523
Query: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2524 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Score = 106 bits (264), Expect = 3e-22
Identities = 327/1505 (21%), Positives = 556/1505 (36%), Gaps = 274/1505 (18%)
Query: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368
Query: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 1369 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1417
Query: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
QK R I QE+L+QL ++ + +A R+
Sbjct: 1418 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1443
Query: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 1444 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1496
Query: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 1497 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1551
Query: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
R L E + + +A++ + A + + + ++ + L E VA
Sbjct: 1552 AERRLRQAE----VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607
Query: 619 LEQSYEA---LCELAAARRARLEESRRLWRFLWEVGEA-----EAWVREQQHLLASADTG 670
+ EA + A A RAR E R L R+ + EA +A QQ LA A+
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667
Query: 671 RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL-QAQW 729
+ A R + RG+ A + + R EL + +
Sbjct: 1668 KQKEEAEREARR----RGK-------------------------AEEQAVRQRELAEQEL 1698
Query: 730 ERLEALAEERA-QRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
E+ LAE A QRLA L + +A+ E R + EL + A ++
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGE-----QQRQLLEEELARLQREAAAATQK 1753
Query: 789 HRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARAL 848
+ LE E+ R ++ L A E + R T E+ + L+A AG
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKA--------RAEEESR-STSEKSKQRLEAEAGRFRELA 1804
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E A L + EA K Q +L + + +QR E LA ++
Sbjct: 1805 EEAARLRALAEEA---------KRQ--------RQLAEEDAARQRAEA----ERVLAEKL 1843
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
A+ + +A K++ E N R RRLA
Sbjct: 1844 AAIGEATRLKTEAEIALKEK-----EAENER---LRRLA--------------------- 1874
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E +A+ R + + E D+ LA RK + +E LE V + R+ +
Sbjct: 1875 EDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQV--- 1927
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTA 1087
+ +A+ A + G +L E LG R +D LRS + + R +
Sbjct: 1928 -EEEILALKASFEKAAAGKAEL-------ELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFL 1143
A EE EAE + + A E R A E RL+A EE R L
Sbjct: 1980 AAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------L 2028
Query: 1144 RQRLEALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
R+R E +L + E+ Q RL +AH F + ++ + L ++ VL ++
Sbjct: 2029 RERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QL 2083
Query: 1201 PGTLQAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIR 1250
G +AA A ++ E+ + ER+ E Q ++ A+K+R
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 1251 EKAD-SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYD 1307
++A+ RR + Q A +Q + + + F + K +++++ T Q D
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 1308 EARN-LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDL 1361
+N L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263
Query: 1362 HRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNIL 1421
L+ + + +A R + AQ L QL +D + +
Sbjct: 2264 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKM 2315
Query: 1422 LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERC 1481
LK++ E + E E +Q Q K LAQE + R E+ + L + +
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQ 2369
Query: 1482 RRLQASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMK 1528
R L+A R+ Q + + E L V E + E G+ L +L +
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2429
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLE 1585
+ TL + + +++ +Q A +AEL+ ++L E L+L+ + ++
Sbjct: 2430 EKVTLVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2481
Query: 1586 DALRAQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
+ Q A ++++ E Q + QEKAK E Q EV K Q L +
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2541
Query: 1641 AQTIHQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEH 1693
Q + Q L AS ++ +H + +Q ++ +L + EL E +RL+E
Sbjct: 2542 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2601
Query: 1694 LRLCQ 1698
L+L +
Sbjct: 2602 LQLLE 2606
Score = 96.7 bits (239), Expect = 2e-19
Identities = 353/1719 (20%), Positives = 645/1719 (37%), Gaps = 237/1719 (13%)
Query: 529 LNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLL-QLHELVEADI-AVQAER 586
L L Q+ + +L L+ WM + + +E L Q + E ++ A +A++
Sbjct: 281 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 340
Query: 587 VR----------AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
R AV A L+ PG Y P D V + KL + A+ E R+
Sbjct: 341 NRSKGIYQSLEGAVQAGQLKV-PPG--YHPLD---VEKEWGKL---HVAILEREKQLRSE 391
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRD--LTGALRLLNKHTALRGEMSGRL 694
E L R + ++ + EA + E+Q A A D L A ++ + + ++
Sbjct: 392 FERLECLQRIVTKL-QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 450
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL-----AQAASL 749
++L Q L HP Q R L ERL A+ E RL A A +
Sbjct: 451 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH---ERLVAIRTEYNLRLKAGVAAPATQV 507
Query: 750 YQFQADA---------------NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEE 794
Q + D+ AW+ + V E G D S +A HR L +
Sbjct: 508 AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 567
Query: 795 EIRSHRPTLDALREQAAALPP-TLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
I R ++ R L P T + GR L+ Y +L + R R+LE+
Sbjct: 568 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGR---LDLQYAKLLNSSKARLRSLES--- 621
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVND 913
L++ ++ A +W+ EKE+ G +R ++ ++ + L E+ +I + +
Sbjct: 622 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 681
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++LL+ + P + + + Q L +W +L +A L + + + E +
Sbjct: 682 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQ 741
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT---REANA---LAA 1027
+++ + + A V L+ L + + E + G L+ + A A L
Sbjct: 742 LQKLQEALRRKYSCDRS-ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 800
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREES--LGEARRLQDFLRSLDDFQAWLGRTQ 1085
HPA + L V ++ + T+ + +E +G A+ + S +A
Sbjct: 801 RHPAHPMRGRLPLLAV-CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA------ 853
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AV S P EA A V R ++++ L L ++ D +
Sbjct: 854 -AVPSVCFLVPPPNQEAQEA--------VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 904
Query: 1146 RLEALGTGWE----ELGRMWESRQGRLAQAHGFQGFLRDARQAEG------VLSSQEYVL 1195
R L W + E RQ + +Q FLRD++ A G +++ +EY
Sbjct: 905 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 964
Query: 1196 SHTEMPGTLQAADAA----------IKKLEDFMSTMDANGER-IHGLLEAGRQLVSEGNI 1244
LQ+ + I +L+D ++A R +H L +
Sbjct: 965 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP---------L 1015
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL------------QDCHELKL 1292
+ RE A I + K + G R + E + L + EL L
Sbjct: 1016 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1075
Query: 1293 WIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E++ + + ++ + + + Q L A+++ L KE + + PEL+A
Sbjct: 1076 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLPELEA 1131
Query: 1353 LVS--EKLRDLHRRWDELETTTQAKARS-LFDANRAELFAQSCCALESWLESLQAQLHSD 1409
+ +KLR QA+A+ FDA R EL E LQ +
Sbjct: 1132 TKASLKKLR------------AQAEAQQPTFDALRDELRGAQEVG-----ERLQQRHGER 1174
Query: 1410 DYGKDLTSVNI--LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVE 1467
D + + LL++ Q + + VR++E+E + Q + + G + +R +
Sbjct: 1175 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1234
Query: 1468 EKFRAL----CQPMRERCRRLQASREQHQFHRDVEDE-------------------ILWV 1504
E+ +A+ Q +RE+ R+ QA E+ + H + +E + +
Sbjct: 1235 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1294
Query: 1505 TERLPMASSME--------------------HGKDLPSV--QLLMKKNQTLQKEIQGHEP 1542
+ P+AS + H +L ++ Q + ++TL++ E
Sbjct: 1295 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR--MEEEE 1352
Query: 1543 RIADLR---ERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
R+A+ + ER+R AA + +L E + + E K L+ ++ + R+ A
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412
Query: 1600 AEAWMGEQELHM-MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
+A ++ + + Q + E QA+ ++ + E++ + I + + E
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR------LQLE 1466
Query: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
E R + ++ L A +E ++R+ +E RL RR++ D Q ++ EV A
Sbjct: 1467 ATERQRGGA-EGELQALRARAEEAEAQKRQAQEEAERL---RRQVQDESQRKRQAEVELA 1522
Query: 1719 SH-----ELGQDYEHVTMLRDKFREFSRDTST-IGQERVDSANALANGLIAGGHAARATV 1772
S E ++ + ++ R + + + Q V+ A + L +A A +
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 1773 AEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR-D 1831
+ S E A L L +A +L+ Q A + +++ R
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L A EAL+ R A E Q Q + + ++A KAEE + +AE +
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1699
Query: 1892 LQGSSA-ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Q A Q L + +A E E Q+ +E R A + +Q
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRLRAETE----QGEQQRQLLEEELARLQREAAAATQKRQ 1755
Query: 1951 GIKAEI-EARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++AE+ + RA+ E+L S AEE S S+ +R E ++
Sbjct: 1756 ELEAELAKVRAEM---------EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA-VAWEER 2068
L L + + L ++ + AE + E + I + A +A +E+
Sbjct: 1807 AARLRALA---EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863
Query: 2069 FCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASV 2107
E+L L E E ++R+ EE+ + + E A +
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1902
Score = 77.4 bits (189), Expect = 2e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 977 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1034
Query: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 1035 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1088
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1148
Query: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1149 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1209 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1266
Query: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1320
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1321 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1377
Query: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1424
Query: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1425 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1479
Query: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1538
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1539 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1591
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1592 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1638
Query: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
+ ++ + Q++ +LA AE + EA +
Sbjct: 1639 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1679
Query: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1680 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729
Query: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1730 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1785
Query: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1901
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 1902 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958
Query: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 1959 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 427 bits (1097), Expect = e-119
Identities = 551/2242 (24%), Positives = 905/2242 (40%), Gaps = 310/2242 (13%)
Query: 53 DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112
DER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP+ KGRMR
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96
Query: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V +
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155
Query: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232
E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D + +
Sbjct: 156 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214
Query: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292
NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++ + +G R
Sbjct: 215 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273
Query: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352
A E + ++Y L LLQW+ +R+ +S ++ F ++
Sbjct: 274 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326
Query: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 327 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 383
Query: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472
LR+E R E L+++ + +A + E L++ L+ D + L A ++ +E
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440
Query: 473 D-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRE 525
D I VQ + + Y + R+ R + ++ + A
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500
Query: 526 RLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLL----Q 571
+ + LQ V + L YL D W+EE + R+ + G L VE L
Sbjct: 501 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 560
Query: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
LH+ +E + + ER R+ L G YR C + +L+ Y +L
Sbjct: 561 LHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY---AKLLN 606
Query: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
+ +ARL L F+ + W+ E++ D T ++AL E+
Sbjct: 607 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 666
Query: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
+ +K G +L+ E HP + A LQ QW + L L + A+ +Q
Sbjct: 667 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 726
Query: 752 FQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALRE 808
F +D + E L +ALR S + + L + + +E++ ++ L L +
Sbjct: 727 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 786
Query: 809 QAAALPPTLSRTP--EVQGRVPTL-------------------------ERHYEELQARA 841
+A A+ R P ++GR+P L H++ L +
Sbjct: 787 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG 846
Query: 842 GERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888
E A A EA L LW + + LA D++
Sbjct: 847 SEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAWQSLRRDVQ 904
Query: 889 VVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE--QLNHR 939
+++ F TL+PE A ++ A + G +DR++ +E +H
Sbjct: 905 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 964
Query: 940 WQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------------ 975
+QQ + L G + S L LE ET+ R
Sbjct: 965 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1024
Query: 976 EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANALAAGH 1029
E+ K +GLG +A + A K+ A EL + +L+A +
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1084
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVA 1089
+ I+ +R Q E LRA EE L EA+ +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV---------------------- 1118
Query: 1090 SEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQADPQC 1140
PATLPE EA A LR + E Q + LR +GE + + + D +
Sbjct: 1119 ----PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174
Query: 1141 LFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDARQAEGVLS 1189
R+R+ L W+ + + RQ L Q A +L+DAR+ + +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 1190 SQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS-----EGNI 1244
+ S QA +++ + + ++ +GE++ +Q ++ E +
Sbjct: 1235 AMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1286
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDCHELKLWID 1295
K + + + + K Q ++ + D R Q+ L+ +
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 1296 EKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE-----------GRE 1342
E+ L Q + + R + +K + A K ++ KE E
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402
++ + K + E+L+ L + E QAKAR A R+ L + E + L
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE----EIRVVRL 1459
Query: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERT 1462
Q + G + L + + E + ++E E ++ Q + +Q + A EVE
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELA 1518
Query: 1463 SR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEH 1516
SR A EK RAL Q + E RLQA + + + + V L A
Sbjct: 1519 SRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE 1576
+ +K L++ +Q +A LRE A + AE + + E
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAERAREEAERE 1630
Query: 1577 LELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK 1628
LE + +ALR AQQ AEAE E E + KA+++ Q E+
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690
Query: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688
+ Q LE+ T Q A+ Q++I R+ Q GE++
Sbjct: 1691 E-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ------------GEQQR 1729
Query: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748
+L E L +L+RE Q QE E A ++ + E + + + E SR TS +
Sbjct: 1730 QLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQVLAAAYELQ 1804
+R+++ L RA E K A D E + LAA E
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 1805 RFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQALSPQVQQV 1859
R A AL + + ++L R L EA QRR ++ DI+ Q+++
Sbjct: 1847 RLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TTDKFRF 1912
D QK D + + + + A + ++A + +L L+ D R
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 1913 -----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE----IEARADRF 1963
+A R+ L +E + +A+ER + +A+ Q+ E ++A+ +
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1964 SSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQLVLEVLVF 2018
+ ++ AR A+E ++K Q + + Q+ ++ Q+ + Q VL+ L
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL 2078
+A A + + E + +VE + ++ ++ A A + A EKL
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 2079 EEREKERKRKREEEERRKQPPA 2100
E+E R+ + E+ R++ A
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAA 2163
Score = 123 bits (309), Expect = 2e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 1166 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225
Query: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 1226 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1402
Query: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 1403 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1447
Query: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 1448 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1549
Query: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609
Query: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1661
Query: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 1662 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1711
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 1712 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1759
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1818
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1874
Query: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 1875 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1914
Query: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 1915 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 2035 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2081
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2489
Query: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2669
Query: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 2670 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2725
Query: 1926 VNLQMDAQ 1933
+ ++AQ
Sbjct: 2726 ALILLEAQ 2733
Score = 122 bits (307), Expect = 3e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 1244 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
K++ E++ + R E L Q++ ++T R +
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1347
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 1348 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 1404 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 1514 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1557
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
+ L A + + + + + Q R + A+ + +
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 1618 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1730
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1786
Query: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1842
Query: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1843 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1890
Query: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 1891 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1933
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 1934 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 1990 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 2164 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2215
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2272
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 2273 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2322
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 2323 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2376
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 2377 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2429
Query: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2483
Query: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 2484 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2536
Query: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 2537 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 2009 LQLVLEVLVFGRDAGMAEA 2027
L+ L++L A +A +
Sbjct: 2594 LREQLQLLEEQHRAALAHS 2612
Score = 117 bits (293), Expect = 1e-25
Identities = 364/1690 (21%), Positives = 633/1690 (37%), Gaps = 277/1690 (16%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
+E++ E ++ +Q I + D +L L + QL+ S K PK + G+
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYEL--QLVTYKAQLEPVAS---PAKKPK-VQSGSES 1311
Query: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
V+ + + + T + + IS E L + E E LA + +E+L ++
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFIS------ETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
A +++ + E ++ + ++ L+ E VR+ EA AVDA
Sbjct: 1366 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEA-------------AVDA 1411
Query: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
+ + + +++++ RQ + A + RQ AA R RL + E++ V
Sbjct: 1412 QQQKRSIQE--ELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV---------- 1457
Query: 547 MEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRP 606
RLQ + R G E LQ A R RA A A + ++ +
Sbjct: 1458 ------RLQLEATERQRGGAEGELQ------------ALRARAEEAEAQK-----RQAQE 1494
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLAS 666
+L + + ++ +A ELA+ +A E +R R L + E E + L
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQA---SARAA 723
A+ R + L + E+ + Q ++ + E H +Q + R A
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 724 ELQAQWERLEALAE---ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
+ QA+ ER AE ER Q A A + QA+ + L A E +
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 781 ----STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSR----TPEVQGRVPTLER 832
+ + RQ E+E+ R + +Q A L R T + + + LE
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734
Query: 833 HYEELQ---ARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEV 889
LQ A A ++ + LEA LA E E+E +RLE
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE---A 1791
Query: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
RF L E AA++ A+ + A+ + R + ++ R + R LA+
Sbjct: 1792 EAGRFRELAEE----AARLRALAEEAK---------RQRQLAEEDAARQRAEAERVLAE- 1837
Query: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLA-LQRKLAGTERDL 1008
K AA+ A ++ TE + ++EK E + L D A L+ + A + D+
Sbjct: 1838 KLAAIGEATRLK------TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 1009 EAIAARV-----GELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE 1063
E A++ EL R+ L Q + + ++ +E A E LG
Sbjct: 1892 EERLAQLRKASDSELERQ-KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 1064 AR-RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVER----AQ 1118
R +D LRS + + R + A EE EAE + + A E R A
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAARQRKAAL 2008
Query: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLA---QAHGFQ 1175
E RL+A EE R LR+R E +L + E+ Q RL +AH F
Sbjct: 2009 EEVERLKAKVEEARR---------LRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF- 2056
Query: 1176 GFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG---------- 1225
+ ++ + L ++ VL ++ G +AA A ++ E+ +
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114
Query: 1226 ERIHGLLEAGRQLVSEGNIHADKIREKADS-IERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
ER+ E Q ++ A+K+R++A+ RR + Q A +Q + + + F
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 1285 QDCHELKLWIDEKMLTA--QDVSYDEARNL-HTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
+ K +++++ T Q D +NL + Q+ +A E A + +++ R
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 1342 ELTLEKPELKALVSEK-----LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
E +LKA + + LRD L+ + + +A R + AQ L
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA 1456
QL +D + +LK++ E + E E +Q Q K LAQE
Sbjct: 2295 --------QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQE---- 2341
Query: 1457 GEVERTSRAVEEKFRALCQPMRERCRRLQASRE-QHQFHRDVEDEILWVTERLPMASSME 1515
+ R E+ + L + + R L+A R+ Q + + E L V E + E
Sbjct: 2342 -QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 1516 H------------GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL 1563
G+ L +L ++ TL + ++ ++ +Q A +
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------IQRQQSDHDAERLREAI 2452
Query: 1564 AELQEMWKRLGHE---LELRGKRLEDALRAQQFYRDAAEAEAWMGE-----QELHMMGQE 1615
AEL+ ++L E L+L+ + ++ + Q A ++++ E Q + QE
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQ----LAASSQDMIDHEHP----------E 1661
KAK E Q EV K Q L + Q + Q L AS ++ +H E
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE------------------- 1702
++ ++ Q ++L A + E+ + L+E R E
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA 2632
Query: 1703 -------------LDDLE-----QWIQEREVVAASH--ELGQDYEHVTML--RDKFREFS 1740
D L Q +QE +++A L Q + V L R+ R +
Sbjct: 2633 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2692
Query: 1741 RDTSTIG-------QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
+ S+I E++ AL L++ G A A+ A LL+ + R
Sbjct: 2693 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ------AASGFLLDPVRNR 2746
Query: 1794 GQVLAAAY-------ELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYE 1846
+ A EL L A +A+ + TG+ ++ +A+Q+ E
Sbjct: 2747 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPY------TGQQISLFQAMQKGLIVRE 2800
Query: 1847 HDIQALSPQV 1856
H I+ L Q+
Sbjct: 2801 HGIRLLEAQI 2810
Score = 115 bits (288), Expect = 5e-25
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 1148 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1203
Query: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 1204 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1262
Query: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 1323 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1372
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
A A + + ++ +V +E QQ R + + + S S
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1430
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1487
Query: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1546
Query: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1847 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2063
Query: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 2184 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2236
Query: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 2237 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2278
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
AAR +VA Q A +L ++ALA ++ K
Sbjct: 2279 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2364
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 2365 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2418
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2464
Query: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2519
Query: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Score = 106 bits (264), Expect = 3e-22
Identities = 327/1505 (21%), Positives = 556/1505 (36%), Gaps = 274/1505 (18%)
Query: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 1365 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1413
Query: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
QK R I QE+L+QL ++ + +A R+
Sbjct: 1414 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1439
Query: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1492
Query: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1547
Query: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
R L E + + +A++ + A + + + ++ + L E VA
Sbjct: 1548 AERRLRQAE----VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 619 LEQSYEA---LCELAAARRARLEESRRLWRFLWEVGEA-----EAWVREQQHLLASADTG 670
+ EA + A A RAR E R L R+ + EA +A QQ LA A+
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 671 RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL-QAQW 729
+ A R + RG+ A + + R EL + +
Sbjct: 1664 KQKEEAEREARR----RGK-------------------------AEEQAVRQRELAEQEL 1694
Query: 730 ERLEALAEERA-QRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
E+ LAE A QRLA L + +A+ E R + EL + A ++
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGE-----QQRQLLEEELARLQREAAAATQK 1749
Query: 789 HRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARAL 848
+ LE E+ R ++ L A E + R T E+ + L+A AG
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKA--------RAEEESR-STSEKSKQRLEAEAGRFRELA 1800
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E A L + EA K Q +L + + +QR E LA ++
Sbjct: 1801 EEAARLRALAEEA---------KRQ--------RQLAEEDAARQRAEA----ERVLAEKL 1839
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
A+ + +A K++ E N R RRLA
Sbjct: 1840 AAIGEATRLKTEAEIALKEK-----EAENER---LRRLA--------------------- 1870
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E +A+ R + + E D+ LA RK + +E LE V + R+ +
Sbjct: 1871 EDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQV--- 1923
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTA 1087
+ +A+ A + G +L E LG R +D LRS + + R +
Sbjct: 1924 -EEEILALKASFEKAAAGKAEL-------ELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFL 1143
A EE EAE + + A E R A E RL+A EE R L
Sbjct: 1976 AAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------L 2024
Query: 1144 RQRLEALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
R+R E +L + E+ Q RL +AH F + ++ + L ++ VL ++
Sbjct: 2025 RERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QL 2079
Query: 1201 PGTLQAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIR 1250
G +AA A ++ E+ + ER+ E Q ++ A+K+R
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 1251 EKAD-SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYD 1307
++A+ RR + Q A +Q + + + F + K +++++ T Q D
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 1308 EARN-LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDL 1361
+N L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259
Query: 1362 HRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNIL 1421
L+ + + +A R + AQ L QL +D + +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKM 2311
Query: 1422 LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERC 1481
LK++ E + E E +Q Q K LAQE + R E+ + L + +
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQ 2365
Query: 1482 RRLQASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMK 1528
R L+A R+ Q + + E L V E + E G+ L +L +
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLE 1585
+ TL + + +++ +Q A +AEL+ ++L E L+L+ + ++
Sbjct: 2426 EKVTLVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 1586 DALRAQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
+ Q A ++++ E Q + QEKAK E Q EV K Q L +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537
Query: 1641 AQTIHQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEH 1693
Q + Q L AS ++ +H + +Q ++ +L + EL E +RL+E
Sbjct: 2538 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Query: 1694 LRLCQ 1698
L+L +
Sbjct: 2598 LQLLE 2602
Score = 96.7 bits (239), Expect = 2e-19
Identities = 353/1719 (20%), Positives = 645/1719 (37%), Gaps = 237/1719 (13%)
Query: 529 LNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLL-QLHELVEADI-AVQAER 586
L L Q+ + +L L+ WM + + +E L Q + E ++ A +A++
Sbjct: 277 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 336
Query: 587 VR----------AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
R AV A L+ PG Y P D V + KL + A+ E R+
Sbjct: 337 NRSKGIYQSLEGAVQAGQLKV-PPG--YHPLD---VEKEWGKL---HVAILEREKQLRSE 387
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRD--LTGALRLLNKHTALRGEMSGRL 694
E L R + ++ + EA + E+Q A A D L A ++ + + ++
Sbjct: 388 FERLECLQRIVTKL-QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 446
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL-----AQAASL 749
++L Q L HP Q R L ERL A+ E RL A A +
Sbjct: 447 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH---ERLVAIRTEYNLRLKAGVAAPATQV 503
Query: 750 YQFQADA---------------NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEE 794
Q + D+ AW+ + V E G D S +A HR L +
Sbjct: 504 AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 563
Query: 795 EIRSHRPTLDALREQAAALPP-TLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
I R ++ R L P T + GR L+ Y +L + R R+LE+
Sbjct: 564 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGR---LDLQYAKLLNSSKARLRSLES--- 617
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVND 913
L++ ++ A +W+ EKE+ G +R ++ ++ + L E+ +I + +
Sbjct: 618 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 677
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++LL+ + P + + + Q L +W +L +A L + + + E +
Sbjct: 678 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQ 737
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT---REANA---LAA 1027
+++ + + A V L+ L + + E + G L+ + A A L
Sbjct: 738 LQKLQEALRRKYSCDRS-ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 796
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREES--LGEARRLQDFLRSLDDFQAWLGRTQ 1085
HPA + L V ++ + T+ + +E +G A+ + S +A
Sbjct: 797 RHPAHPMRGRLPLLAV-CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA------ 849
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AV S P EA A V R ++++ L L ++ D +
Sbjct: 850 -AVPSVCFLVPPPNQEAQEA--------VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 900
Query: 1146 RLEALGTGWE----ELGRMWESRQGRLAQAHGFQGFLRDARQAEG------VLSSQEYVL 1195
R L W + E RQ + +Q FLRD++ A G +++ +EY
Sbjct: 901 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 960
Query: 1196 SHTEMPGTLQAADAA----------IKKLEDFMSTMDANGER-IHGLLEAGRQLVSEGNI 1244
LQ+ + I +L+D ++A R +H L +
Sbjct: 961 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP---------L 1011
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL------------QDCHELKL 1292
+ RE A I + K + G R + E + L + EL L
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 1293 WIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E++ + + ++ + + + Q L A+++ L KE + + PEL+A
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLPELEA 1127
Query: 1353 LVS--EKLRDLHRRWDELETTTQAKARS-LFDANRAELFAQSCCALESWLESLQAQLHSD 1409
+ +KLR QA+A+ FDA R EL E LQ +
Sbjct: 1128 TKASLKKLR------------AQAEAQQPTFDALRDELRGAQEVG-----ERLQQRHGER 1170
Query: 1410 DYGKDLTSVNI--LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVE 1467
D + + LL++ Q + + VR++E+E + Q + + G + +R +
Sbjct: 1171 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230
Query: 1468 EKFRAL----CQPMRERCRRLQASREQHQFHRDVEDE-------------------ILWV 1504
E+ +A+ Q +RE+ R+ QA E+ + H + +E + +
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290
Query: 1505 TERLPMASSME--------------------HGKDLPSV--QLLMKKNQTLQKEIQGHEP 1542
+ P+AS + H +L ++ Q + ++TL++ E
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR--MEEEE 1348
Query: 1543 RIADLR---ERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
R+A+ + ER+R AA + +L E + + E K L+ ++ + R+ A
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 1600 AEAWMGEQELHM-MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
+A ++ + + Q + E QA+ ++ + E++ + I + + E
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR------LQLE 1462
Query: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
E R + ++ L A +E ++R+ +E RL RR++ D Q ++ EV A
Sbjct: 1463 ATERQRGGA-EGELQALRARAEEAEAQKRQAQEEAERL---RRQVQDESQRKRQAEVELA 1518
Query: 1719 SH-----ELGQDYEHVTMLRDKFREFSRDTST-IGQERVDSANALANGLIAGGHAARATV 1772
S E ++ + ++ R + + + Q V+ A + L +A A +
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 1773 AEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR-D 1831
+ S E A L L +A +L+ Q A + +++ R
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L A EAL+ R A E Q Q + + ++A KAEE + +AE +
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 1892 LQGSSA-ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Q A Q L + +A E E Q+ +E R A + +Q
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETE----QGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 1951 GIKAEI-EARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++AE+ + RA+ E+L S AEE S S+ +R E ++
Sbjct: 1752 ELEAELAKVRAEM---------EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA-VAWEER 2068
L L + + L ++ + AE + E + I + A +A +E+
Sbjct: 1803 AARLRALA---EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 2069 FCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASV 2107
E+L L E E ++R+ EE+ + + E A +
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Score = 77.4 bits (189), Expect = 2e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 973 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1030
Query: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 1031 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1084
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1205 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1316
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1317 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1373
Query: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1420
Query: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1421 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1475
Query: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1534
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1535 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1587
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1588 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1634
Query: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
+ ++ + Q++ +LA AE + EA +
Sbjct: 1635 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1675
Query: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1676 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1726 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1897
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 1898 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 427 bits (1097), Expect = e-119
Identities = 551/2242 (24%), Positives = 905/2242 (40%), Gaps = 310/2242 (13%)
Query: 53 DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112
DER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP+ KGRMR
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233
Query: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V +
Sbjct: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292
Query: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232
E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D + +
Sbjct: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351
Query: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292
NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++ + +G R
Sbjct: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410
Query: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352
A E + ++Y L LLQW+ +R+ +S ++ F ++
Sbjct: 411 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463
Query: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 464 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520
Query: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472
LR+E R E L+++ + +A + E L++ L+ D + L A ++ +E
Sbjct: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577
Query: 473 D-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRE 525
D I VQ + + Y + R+ R + ++ + A
Sbjct: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 637
Query: 526 RLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLL----Q 571
+ + LQ V + L YL D W+EE + R+ + G L VE L
Sbjct: 638 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 697
Query: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
LH+ +E + + ER R+ L G YR C + +L+ Y +L
Sbjct: 698 LHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY---AKLLN 743
Query: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
+ +ARL L F+ + W+ E++ D T ++AL E+
Sbjct: 744 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 803
Query: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
+ +K G +L+ E HP + A LQ QW + L L + A+ +Q
Sbjct: 804 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 863
Query: 752 FQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALRE 808
F +D + E L +ALR S + + L + + +E++ ++ L L +
Sbjct: 864 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 923
Query: 809 QAAALPPTLSRTP--EVQGRVPTL-------------------------ERHYEELQARA 841
+A A+ R P ++GR+P L H++ L +
Sbjct: 924 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG 983
Query: 842 GERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888
E A A EA L LW + + LA D++
Sbjct: 984 SEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAWQSLRRDVQ 1041
Query: 889 VVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE--QLNHR 939
+++ F TL+PE A ++ A + G +DR++ +E +H
Sbjct: 1042 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1101
Query: 940 WQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------------ 975
+QQ + L G + S L LE ET+ R
Sbjct: 1102 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1161
Query: 976 EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANALAAGH 1029
E+ K +GLG +A + A K+ A EL + +L+A +
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1221
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVA 1089
+ I+ +R Q E LRA EE L EA+ +
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV---------------------- 1255
Query: 1090 SEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQADPQC 1140
PATLPE EA A LR + E Q + LR +GE + + + D +
Sbjct: 1256 ----PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1311
Query: 1141 LFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDARQAEGVLS 1189
R+R+ L W+ + + RQ L Q A +L+DAR+ + +
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371
Query: 1190 SQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS-----EGNI 1244
+ S QA +++ + + ++ +GE++ +Q ++ E +
Sbjct: 1372 AMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1423
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDCHELKLWID 1295
K + + + + K Q ++ + D R Q+ L+ +
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1483
Query: 1296 EKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE-----------GRE 1342
E+ L Q + + R + +K + A K ++ KE E
Sbjct: 1484 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543
Query: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402
++ + K + E+L+ L + E QAKAR A R+ L + E + L
Sbjct: 1544 AAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE----EIRVVRL 1596
Query: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERT 1462
Q + G + L + + E + ++E E ++ Q + +Q + A EVE
Sbjct: 1597 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELA 1655
Query: 1463 SR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEH 1516
SR A EK RAL Q + E RLQA + + + + V L A
Sbjct: 1656 SRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE 1576
+ +K L++ +Q +A LRE A + AE + + E
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAERAREEAERE 1767
Query: 1577 LELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK 1628
LE + +ALR AQQ AEAE E E + KA+++ Q E+
Sbjct: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827
Query: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688
+ Q LE+ T Q A+ Q++I R+ Q GE++
Sbjct: 1828 E-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ------------GEQQR 1866
Query: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748
+L E L +L+RE Q QE E A ++ + E + + + E SR TS +
Sbjct: 1867 QLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQVLAAAYELQ 1804
+R+++ L RA E K A D E + LAA E
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 1805 RFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQALSPQVQQV 1859
R A AL + + ++L R L EA QRR ++ DI+ Q+++
Sbjct: 1984 RLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038
Query: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TTDKFRF 1912
D QK D + + + + A + ++A + +L L+ D R
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 1913 -----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE----IEARADRF 1963
+A R+ L +E + +A+ER + +A+ Q+ E ++A+ +
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 1964 SSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQLVLEVLVF 2018
+ ++ AR A+E ++K Q + + Q+ ++ Q+ + Q VL+ L
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL 2078
+A A + + E + +VE + ++ ++ A A + A EKL
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 2079 EEREKERKRKREEEERRKQPPA 2100
E+E R+ + E+ R++ A
Sbjct: 2279 AEQEAARRAQAEQAALRQKQAA 2300
Score = 123 bits (309), Expect = 2e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 1303 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1362
Query: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 1363 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1421
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481
Query: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1539
Query: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 1540 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1584
Query: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 1585 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636
Query: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1686
Query: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746
Query: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1798
Query: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 1799 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1848
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 1849 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1896
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1955
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1956 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 2011
Query: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 2012 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 2051
Query: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 2052 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2111
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2171
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 2172 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2218
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2272
Query: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332
Query: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2450
Query: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2626
Query: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2746
Query: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 2747 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2806
Query: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 2807 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2862
Query: 1926 VNLQMDAQ 1933
+ ++AQ
Sbjct: 2863 ALILLEAQ 2870
Score = 122 bits (307), Expect = 3e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320
Query: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380
Query: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 1381 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1439
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
K++ E++ + R E L Q++ ++T R +
Sbjct: 1440 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1484
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 1485 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 1541 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
Query: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 1651 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1694
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
+ L A + + + + + Q R + A+ + +
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 1755 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1867
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1923
Query: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1979
Query: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1980 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 2027
Query: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 2028 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 2070
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 2071 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 2127 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2240
Query: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300
Query: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 2301 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2352
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2409
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 2410 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2459
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 2460 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2513
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 2514 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2566
Query: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 2567 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2620
Query: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 2621 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2673
Query: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 2674 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730
Query: 2009 LQLVLEVLVFGRDAGMAEA 2027
L+ L++L A +A +
Sbjct: 2731 LREQLQLLEEQHRAALAHS 2749
Score = 117 bits (293), Expect = 1e-25
Identities = 364/1690 (21%), Positives = 633/1690 (37%), Gaps = 277/1690 (16%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
+E++ E ++ +Q I + D +L L + QL+ S K PK + G+
Sbjct: 1395 IERHGEKVEECQRFAKQYINAIKDYEL--QLVTYKAQLEPVAS---PAKKPK-VQSGSES 1448
Query: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
V+ + + + T + + IS E L + E E LA + +E+L ++
Sbjct: 1449 VIQEYVDLRTHYSELTTLTSQYIKFIS------ETLRRMEEEERLAEQQRAEERERLAEV 1502
Query: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
A +++ + E ++ + ++ L+ E VR+ EA AVDA
Sbjct: 1503 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEA-------------AVDA 1548
Query: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
+ + + +++++ RQ + A + RQ AA R RL + E++ V
Sbjct: 1549 QQQKRSIQE--ELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV---------- 1594
Query: 547 MEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRP 606
RLQ + R G E LQ A R RA A A + ++ +
Sbjct: 1595 ------RLQLEATERQRGGAEGELQ------------ALRARAEEAEAQK-----RQAQE 1631
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLAS 666
+L + + ++ +A ELA+ +A E +R R L + E E + L
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1691
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQA---SARAA 723
A+ R + L + E+ + Q ++ + E H +Q + R A
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1751
Query: 724 ELQAQWERLEALAE---ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
+ QA+ ER AE ER Q A A + QA+ + L A E +
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1811
Query: 781 ----STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSR----TPEVQGRVPTLER 832
+ + RQ E+E+ R + +Q A L R T + + + LE
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1871
Query: 833 HYEELQ---ARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEV 889
LQ A A ++ + LEA LA E E+E +RLE
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE---A 1928
Query: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
RF L E AA++ A+ + A+ + R + ++ R + R LA+
Sbjct: 1929 EAGRFRELAEE----AARLRALAEEAK---------RQRQLAEEDAARQRAEAERVLAE- 1974
Query: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLA-LQRKLAGTERDL 1008
K AA+ A ++ TE + ++EK E + L D A L+ + A + D+
Sbjct: 1975 KLAAIGEATRLK------TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028
Query: 1009 EAIAARV-----GELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE 1063
E A++ EL R+ L Q + + ++ +E A E LG
Sbjct: 2029 EERLAQLRKASDSELERQ-KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Query: 1064 AR-RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVER----AQ 1118
R +D LRS + + R + A EE EAE + + A E R A
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAARQRKAAL 2145
Query: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLA---QAHGFQ 1175
E RL+A EE R LR+R E +L + E+ Q RL +AH F
Sbjct: 2146 EEVERLKAKVEEARR---------LRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF- 2193
Query: 1176 GFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG---------- 1225
+ ++ + L ++ VL ++ G +AA A ++ E+ +
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2251
Query: 1226 ERIHGLLEAGRQLVSEGNIHADKIREKADS-IERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
ER+ E Q ++ A+K+R++A+ RR + Q A +Q + + + F
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311
Query: 1285 QDCHELKLWIDEKMLTA--QDVSYDEARNL-HTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
+ K +++++ T Q D +NL + Q+ +A E A + +++ R
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 1342 ELTLEKPELKALVSEK-----LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
E +LKA + + LRD L+ + + +A R + AQ L
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA 1456
QL +D + +LK++ E + E E +Q Q K LAQE
Sbjct: 2432 --------QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQE---- 2478
Query: 1457 GEVERTSRAVEEKFRALCQPMRERCRRLQASRE-QHQFHRDVEDEILWVTERLPMASSME 1515
+ R E+ + L + + R L+A R+ Q + + E L V E + E
Sbjct: 2479 -QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537
Query: 1516 H------------GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL 1563
G+ L +L ++ TL + ++ ++ +Q A +
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------IQRQQSDHDAERLREAI 2589
Query: 1564 AELQEMWKRLGHE---LELRGKRLEDALRAQQFYRDAAEAEAWMGE-----QELHMMGQE 1615
AEL+ ++L E L+L+ + ++ + Q A ++++ E Q + QE
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2649
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQ----LAASSQDMIDHEHP----------E 1661
KAK E Q EV K Q L + Q + Q L AS ++ +H E
Sbjct: 2650 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2709
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE------------------- 1702
++ ++ Q ++L A + E+ + L+E R E
Sbjct: 2710 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA 2769
Query: 1703 -------------LDDLE-----QWIQEREVVAASH--ELGQDYEHVTML--RDKFREFS 1740
D L Q +QE +++A L Q + V L R+ R +
Sbjct: 2770 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2829
Query: 1741 RDTSTIG-------QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
+ S+I E++ AL L++ G A A+ A LL+ + R
Sbjct: 2830 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ------AASGFLLDPVRNR 2883
Query: 1794 GQVLAAAY-------ELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYE 1846
+ A EL L A +A+ + TG+ ++ +A+Q+ E
Sbjct: 2884 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPY------TGQQISLFQAMQKGLIVRE 2937
Query: 1847 HDIQALSPQV 1856
H I+ L Q+
Sbjct: 2938 HGIRLLEAQI 2947
Score = 115 bits (288), Expect = 5e-25
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 1285 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1340
Query: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 1341 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1399
Query: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 1460 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1509
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
A A + + ++ +V +E QQ R + + + S S
Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1567
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1624
Query: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1683
Query: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1984 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100
Query: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160
Query: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2200
Query: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260
Query: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2320
Query: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 2321 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2373
Query: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 2374 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2415
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
AAR +VA Q A +L ++ALA ++ K
Sbjct: 2416 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2452
Query: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2501
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 2502 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2555
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 2556 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2601
Query: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2656
Query: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2657 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Score = 106 bits (264), Expect = 3e-22
Identities = 327/1505 (21%), Positives = 556/1505 (36%), Gaps = 274/1505 (18%)
Query: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501
Query: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 1502 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1550
Query: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
QK R I QE+L+QL ++ + +A R+
Sbjct: 1551 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1576
Query: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1629
Query: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 1630 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1684
Query: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
R L E + + +A++ + A + + + ++ + L E VA
Sbjct: 1685 AERRLRQAE----VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740
Query: 619 LEQSYEA---LCELAAARRARLEESRRLWRFLWEVGEA-----EAWVREQQHLLASADTG 670
+ EA + A A RAR E R L R+ + EA +A QQ LA A+
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800
Query: 671 RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL-QAQW 729
+ A R + RG+ A + + R EL + +
Sbjct: 1801 KQKEEAEREARR----RGK-------------------------AEEQAVRQRELAEQEL 1831
Query: 730 ERLEALAEERA-QRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
E+ LAE A QRLA L + +A+ E R + EL + A ++
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGE-----QQRQLLEEELARLQREAAAATQK 1886
Query: 789 HRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARAL 848
+ LE E+ R ++ L A E + R T E+ + L+A AG
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKA--------RAEEESR-STSEKSKQRLEAEAGRFRELA 1937
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E A L + EA K Q +L + + +QR E LA ++
Sbjct: 1938 EEAARLRALAEEA---------KRQ--------RQLAEEDAARQRAEA----ERVLAEKL 1976
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
A+ + +A K++ E N R RRLA
Sbjct: 1977 AAIGEATRLKTEAEIALKEK-----EAENER---LRRLA--------------------- 2007
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E +A+ R + + E D+ LA RK + +E LE V + R+ +
Sbjct: 2008 EDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQV--- 2060
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTA 1087
+ +A+ A + G +L E LG R +D LRS + + R +
Sbjct: 2061 -EEEILALKASFEKAAAGKAEL-------ELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFL 1143
A EE EAE + + A E R A E RL+A EE R L
Sbjct: 2113 AAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------L 2161
Query: 1144 RQRLEALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
R+R E +L + E+ Q RL +AH F + ++ + L ++ VL ++
Sbjct: 2162 RERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QL 2216
Query: 1201 PGTLQAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIR 1250
G +AA A ++ E+ + ER+ E Q ++ A+K+R
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 1251 EKAD-SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYD 1307
++A+ RR + Q A +Q + + + F + K +++++ T Q D
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 1308 EARN-LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDL 1361
+N L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2396
Query: 1362 HRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNIL 1421
L+ + + +A R + AQ L QL +D + +
Sbjct: 2397 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKM 2448
Query: 1422 LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERC 1481
LK++ E + E E +Q Q K LAQE + R E+ + L + +
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQ 2502
Query: 1482 RRLQASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMK 1528
R L+A R+ Q + + E L V E + E G+ L +L +
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2562
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLE 1585
+ TL + + +++ +Q A +AEL+ ++L E L+L+ + ++
Sbjct: 2563 EKVTLVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2614
Query: 1586 DALRAQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
+ Q A ++++ E Q + QEKAK E Q EV K Q L +
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2674
Query: 1641 AQTIHQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEH 1693
Q + Q L AS ++ +H + +Q ++ +L + EL E +RL+E
Sbjct: 2675 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2734
Query: 1694 LRLCQ 1698
L+L +
Sbjct: 2735 LQLLE 2739
Score = 96.7 bits (239), Expect = 2e-19
Identities = 353/1719 (20%), Positives = 645/1719 (37%), Gaps = 237/1719 (13%)
Query: 529 LNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLL-QLHELVEADI-AVQAER 586
L L Q+ + +L L+ WM + + +E L Q + E ++ A +A++
Sbjct: 414 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 473
Query: 587 VR----------AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
R AV A L+ PG Y P D V + KL + A+ E R+
Sbjct: 474 NRSKGIYQSLEGAVQAGQLKV-PPG--YHPLD---VEKEWGKL---HVAILEREKQLRSE 524
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRD--LTGALRLLNKHTALRGEMSGRL 694
E L R + ++ + EA + E+Q A A D L A ++ + + ++
Sbjct: 525 FERLECLQRIVTKL-QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 583
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL-----AQAASL 749
++L Q L HP Q R L ERL A+ E RL A A +
Sbjct: 584 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH---ERLVAIRTEYNLRLKAGVAAPATQV 640
Query: 750 YQFQADA---------------NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEE 794
Q + D+ AW+ + V E G D S +A HR L +
Sbjct: 641 AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 700
Query: 795 EIRSHRPTLDALREQAAALPP-TLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
I R ++ R L P T + GR L+ Y +L + R R+LE+
Sbjct: 701 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGR---LDLQYAKLLNSSKARLRSLES--- 754
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVND 913
L++ ++ A +W+ EKE+ G +R ++ ++ + L E+ +I + +
Sbjct: 755 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 814
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++LL+ + P + + + Q L +W +L +A L + + + E +
Sbjct: 815 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQ 874
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT---REANA---LAA 1027
+++ + + A V L+ L + + E + G L+ + A A L
Sbjct: 875 LQKLQEALRRKYSCDRS-ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 933
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREES--LGEARRLQDFLRSLDDFQAWLGRTQ 1085
HPA + L V ++ + T+ + +E +G A+ + S +A
Sbjct: 934 RHPAHPMRGRLPLLAV-CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA------ 986
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AV S P EA A V R ++++ L L ++ D +
Sbjct: 987 -AVPSVCFLVPPPNQEAQEA--------VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 1037
Query: 1146 RLEALGTGWE----ELGRMWESRQGRLAQAHGFQGFLRDARQAEG------VLSSQEYVL 1195
R L W + E RQ + +Q FLRD++ A G +++ +EY
Sbjct: 1038 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1097
Query: 1196 SHTEMPGTLQAADAA----------IKKLEDFMSTMDANGER-IHGLLEAGRQLVSEGNI 1244
LQ+ + I +L+D ++A R +H L +
Sbjct: 1098 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP---------L 1148
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL------------QDCHELKL 1292
+ RE A I + K + G R + E + L + EL L
Sbjct: 1149 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1208
Query: 1293 WIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E++ + + ++ + + + Q L A+++ L KE + + PEL+A
Sbjct: 1209 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLPELEA 1264
Query: 1353 LVS--EKLRDLHRRWDELETTTQAKARS-LFDANRAELFAQSCCALESWLESLQAQLHSD 1409
+ +KLR QA+A+ FDA R EL E LQ +
Sbjct: 1265 TKASLKKLR------------AQAEAQQPTFDALRDELRGAQEVG-----ERLQQRHGER 1307
Query: 1410 DYGKDLTSVNI--LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVE 1467
D + + LL++ Q + + VR++E+E + Q + + G + +R +
Sbjct: 1308 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1367
Query: 1468 EKFRAL----CQPMRERCRRLQASREQHQFHRDVEDE-------------------ILWV 1504
E+ +A+ Q +RE+ R+ QA E+ + H + +E + +
Sbjct: 1368 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1427
Query: 1505 TERLPMASSME--------------------HGKDLPSV--QLLMKKNQTLQKEIQGHEP 1542
+ P+AS + H +L ++ Q + ++TL++ E
Sbjct: 1428 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR--MEEEE 1485
Query: 1543 RIADLR---ERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
R+A+ + ER+R AA + +L E + + E K L+ ++ + R+ A
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545
Query: 1600 AEAWMGEQELHM-MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
+A ++ + + Q + E QA+ ++ + E++ + I + + E
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR------LQLE 1599
Query: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
E R + ++ L A +E ++R+ +E RL RR++ D Q ++ EV A
Sbjct: 1600 ATERQRGGA-EGELQALRARAEEAEAQKRQAQEEAERL---RRQVQDESQRKRQAEVELA 1655
Query: 1719 SH-----ELGQDYEHVTMLRDKFREFSRDTST-IGQERVDSANALANGLIAGGHAARATV 1772
S E ++ + ++ R + + + Q V+ A + L +A A +
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1715
Query: 1773 AEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR-D 1831
+ S E A L L +A +L+ Q A + +++ R
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L A EAL+ R A E Q Q + + ++A KAEE + +AE +
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1832
Query: 1892 LQGSSA-ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Q A Q L + +A E E Q+ +E R A + +Q
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETE----QGEQQRQLLEEELARLQREAAAATQKRQ 1888
Query: 1951 GIKAEI-EARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++AE+ + RA+ E+L S AEE S S+ +R E ++
Sbjct: 1889 ELEAELAKVRAEM---------EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA-VAWEER 2068
L L + + L ++ + AE + E + I + A +A +E+
Sbjct: 1940 AARLRALA---EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1996
Query: 2069 FCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASV 2107
E+L L E E ++R+ EE+ + + E A +
Sbjct: 1997 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035
Score = 77.4 bits (189), Expect = 2e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 1110 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1167
Query: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 1168 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1221
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281
Query: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1342 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1399
Query: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1453
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1454 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1510
Query: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1557
Query: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1558 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1612
Query: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1671
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1672 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1724
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1725 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1771
Query: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
+ ++ + Q++ +LA AE + EA +
Sbjct: 1772 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1812
Query: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1813 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862
Query: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1863 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1918
Query: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1979 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 2034
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 2035 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091
Query: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 427 bits (1097), Expect = e-119
Identities = 551/2242 (24%), Positives = 905/2242 (40%), Gaps = 310/2242 (13%)
Query: 53 DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112
DER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP+ KGRMR
Sbjct: 24 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 82
Query: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V +
Sbjct: 83 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 141
Query: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232
E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D + +
Sbjct: 142 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 200
Query: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292
NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++ + +G R
Sbjct: 201 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 259
Query: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352
A E + ++Y L LLQW+ +R+ +S ++ F ++
Sbjct: 260 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 312
Query: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 313 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 369
Query: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472
LR+E R E L+++ + +A + E L++ L+ D + L A ++ +E
Sbjct: 370 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 426
Query: 473 D-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRE 525
D I VQ + + Y + R+ R + ++ + A
Sbjct: 427 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 486
Query: 526 RLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLL----Q 571
+ + LQ V + L YL D W+EE + R+ + G L VE L
Sbjct: 487 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 546
Query: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
LH+ +E + + ER R+ L G YR C + +L+ Y +L
Sbjct: 547 LHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY---AKLLN 592
Query: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
+ +ARL L F+ + W+ E++ D T ++AL E+
Sbjct: 593 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 652
Query: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
+ +K G +L+ E HP + A LQ QW + L L + A+ +Q
Sbjct: 653 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 712
Query: 752 FQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALRE 808
F +D + E L +ALR S + + L + + +E++ ++ L L +
Sbjct: 713 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 772
Query: 809 QAAALPPTLSRTP--EVQGRVPTL-------------------------ERHYEELQARA 841
+A A+ R P ++GR+P L H++ L +
Sbjct: 773 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG 832
Query: 842 GERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888
E A A EA L LW + + LA D++
Sbjct: 833 SEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAWQSLRRDVQ 890
Query: 889 VVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE--QLNHR 939
+++ F TL+PE A ++ A + G +DR++ +E +H
Sbjct: 891 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 950
Query: 940 WQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------------ 975
+QQ + L G + S L LE ET+ R
Sbjct: 951 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1010
Query: 976 EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANALAAGH 1029
E+ K +GLG +A + A K+ A EL + +L+A +
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1070
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVA 1089
+ I+ +R Q E LRA EE L EA+ +
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV---------------------- 1104
Query: 1090 SEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQADPQC 1140
PATLPE EA A LR + E Q + LR +GE + + + D +
Sbjct: 1105 ----PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1160
Query: 1141 LFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDARQAEGVLS 1189
R+R+ L W+ + + RQ L Q A +L+DAR+ + +
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
Query: 1190 SQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS-----EGNI 1244
+ S QA +++ + + ++ +GE++ +Q ++ E +
Sbjct: 1221 AMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1272
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDCHELKLWID 1295
K + + + + K Q ++ + D R Q+ L+ +
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1332
Query: 1296 EKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE-----------GRE 1342
E+ L Q + + R + +K + A K ++ KE E
Sbjct: 1333 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1392
Query: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402
++ + K + E+L+ L + E QAKAR A R+ L + E + L
Sbjct: 1393 AAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE----EIRVVRL 1445
Query: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERT 1462
Q + G + L + + E + ++E E ++ Q + +Q + A EVE
Sbjct: 1446 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELA 1504
Query: 1463 SR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEH 1516
SR A EK RAL Q + E RLQA + + + + V L A
Sbjct: 1505 SRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE 1576
+ +K L++ +Q +A LRE A + AE + + E
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAERAREEAERE 1616
Query: 1577 LELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK 1628
LE + +ALR AQQ AEAE E E + KA+++ Q E+
Sbjct: 1617 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1676
Query: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688
+ Q LE+ T Q A+ Q++I R+ Q GE++
Sbjct: 1677 E-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ------------GEQQR 1715
Query: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748
+L E L +L+RE Q QE E A ++ + E + + + E SR TS +
Sbjct: 1716 QLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQVLAAAYELQ 1804
+R+++ L RA E K A D E + LAA E
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 1805 RFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQALSPQVQQV 1859
R A AL + + ++L R L EA QRR ++ DI+ Q+++
Sbjct: 1833 RLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887
Query: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TTDKFRF 1912
D QK D + + + + A + ++A + +L L+ D R
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 1913 -----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE----IEARADRF 1963
+A R+ L +E + +A+ER + +A+ Q+ E ++A+ +
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 1964 SSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQLVLEVLVF 2018
+ ++ AR A+E ++K Q + + Q+ ++ Q+ + Q VL+ L
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2067
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL 2078
+A A + + E + +VE + ++ ++ A A + A EKL
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 2079 EEREKERKRKREEEERRKQPPA 2100
E+E R+ + E+ R++ A
Sbjct: 2128 AEQEAARRAQAEQAALRQKQAA 2149
Score = 123 bits (309), Expect = 2e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 1152 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1211
Query: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 1212 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1270
Query: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330
Query: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1388
Query: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 1389 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1433
Query: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 1434 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1485
Query: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 1486 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1535
Query: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1595
Query: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1647
Query: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 1648 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1697
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 1698 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1745
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1804
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1805 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1860
Query: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 1861 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1900
Query: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 1901 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1960
Query: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 1961 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2020
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 2021 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2067
Query: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2121
Query: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181
Query: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2241
Query: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2299
Query: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2475
Query: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2595
Query: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 2596 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2655
Query: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 2656 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2711
Query: 1926 VNLQMDAQ 1933
+ ++AQ
Sbjct: 2712 ALILLEAQ 2719
Score = 122 bits (307), Expect = 3e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 1110 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1169
Query: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 1170 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1229
Query: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 1230 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1288
Query: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
K++ E++ + R E L Q++ ++T R +
Sbjct: 1289 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1333
Query: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 1334 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 1390 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
Query: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 1440 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 1500 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1543
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
+ L A + + + + + Q R + A+ + +
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1603
Query: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 1604 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1716
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1772
Query: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1828
Query: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1829 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1876
Query: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 1877 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1919
Query: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 1920 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975
Query: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 1976 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2089
Query: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149
Query: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 2150 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2201
Query: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2258
Query: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 2259 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2308
Query: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 2309 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2362
Query: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 2363 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2415
Query: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 2416 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2469
Query: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 2470 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2522
Query: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 2523 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579
Query: 2009 LQLVLEVLVFGRDAGMAEA 2027
L+ L++L A +A +
Sbjct: 2580 LREQLQLLEEQHRAALAHS 2598
Score = 117 bits (293), Expect = 1e-25
Identities = 364/1690 (21%), Positives = 633/1690 (37%), Gaps = 277/1690 (16%)
Query: 307 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
+E++ E ++ +Q I + D +L L + QL+ S K PK + G+
Sbjct: 1244 IERHGEKVEECQRFAKQYINAIKDYEL--QLVTYKAQLEPVAS---PAKKPK-VQSGSES 1297
Query: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
V+ + + + T + + IS E L + E E LA + +E+L ++
Sbjct: 1298 VIQEYVDLRTHYSELTTLTSQYIKFIS------ETLRRMEEEERLAEQQRAEERERLAEV 1351
Query: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
A +++ + E ++ + ++ L+ E VR+ EA AVDA
Sbjct: 1352 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEA-------------AVDA 1397
Query: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
+ + + +++++ RQ + A + RQ AA R RL + E++ V
Sbjct: 1398 QQQKRSIQE--ELQQL--RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV---------- 1443
Query: 547 MEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRP 606
RLQ + R G E LQ A R RA A A + ++ +
Sbjct: 1444 ------RLQLEATERQRGGAEGELQ------------ALRARAEEAEAQK-----RQAQE 1480
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLAS 666
+L + + ++ +A ELA+ +A E +R R L + E E + L
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1540
Query: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQA---SARAA 723
A+ R + L + E+ + Q ++ + E H +Q + R A
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1600
Query: 724 ELQAQWERLEALAE---ERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 780
+ QA+ ER AE ER Q A A + QA+ + L A E +
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1660
Query: 781 ----STQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSR----TPEVQGRVPTLER 832
+ + RQ E+E+ R + +Q A L R T + + + LE
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1720
Query: 833 HYEELQ---ARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEV 889
LQ A A ++ + LEA LA E E+E +RLE
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE---A 1777
Query: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
RF L E AA++ A+ + A+ + R + ++ R + R LA+
Sbjct: 1778 EAGRFRELAEE----AARLRALAEEAK---------RQRQLAEEDAARQRAEAERVLAE- 1823
Query: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLA-LQRKLAGTERDL 1008
K AA+ A ++ TE + ++EK E + L D A L+ + A + D+
Sbjct: 1824 KLAAIGEATRLK------TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877
Query: 1009 EAIAARV-----GELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE 1063
E A++ EL R+ L Q + + ++ +E A E LG
Sbjct: 1878 EERLAQLRKASDSELERQ-KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936
Query: 1064 AR-RLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVER----AQ 1118
R +D LRS + + R + A EE EAE + + A E R A
Sbjct: 1937 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAARQRKAAL 1994
Query: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLA---QAHGFQ 1175
E RL+A EE R LR+R E +L + E+ Q RL +AH F
Sbjct: 1995 EEVERLKAKVEEARR---------LRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF- 2042
Query: 1176 GFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG---------- 1225
+ ++ + L ++ VL ++ G +AA A ++ E+ +
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2100
Query: 1226 ERIHGLLEAGRQLVSEGNIHADKIREKADS-IERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
ER+ E Q ++ A+K+R++A+ RR + Q A +Q + + + F
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160
Query: 1285 QDCHELKLWIDEKMLTA--QDVSYDEARNL-HTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
+ K +++++ T Q D +NL + Q+ +A E A + +++ R
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 1342 ELTLEKPELKALVSEK-----LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
E +LKA + + LRD L+ + + +A R + AQ L
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 1397 SWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGA 1456
QL +D + +LK++ E + E E +Q Q K LAQE
Sbjct: 2281 --------QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQE---- 2327
Query: 1457 GEVERTSRAVEEKFRALCQPMRERCRRLQASRE-QHQFHRDVEDEILWVTERLPMASSME 1515
+ R E+ + L + + R L+A R+ Q + + E L V E + E
Sbjct: 2328 -QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2386
Query: 1516 H------------GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL 1563
G+ L +L ++ TL + ++ ++ +Q A +
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE--------IQRQQSDHDAERLREAI 2438
Query: 1564 AELQEMWKRLGHE---LELRGKRLEDALRAQQFYRDAAEAEAWMGE-----QELHMMGQE 1615
AEL+ ++L E L+L+ + ++ + Q A ++++ E Q + QE
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2498
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQ----LAASSQDMIDHEHP----------E 1661
KAK E Q EV K Q L + Q + Q L AS ++ +H E
Sbjct: 2499 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2558
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE------------------- 1702
++ ++ Q ++L A + E+ + L+E R E
Sbjct: 2559 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA 2618
Query: 1703 -------------LDDLE-----QWIQEREVVAASH--ELGQDYEHVTML--RDKFREFS 1740
D L Q +QE +++A L Q + V L R+ R +
Sbjct: 2619 LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYL 2678
Query: 1741 RDTSTIG-------QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
+ S+I E++ AL L++ G A A+ A LL+ + R
Sbjct: 2679 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ------AASGFLLDPVRNR 2732
Query: 1794 GQVLAAAY-------ELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYE 1846
+ A EL L A +A+ + TG+ ++ +A+Q+ E
Sbjct: 2733 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPY------TGQQISLFQAMQKGLIVRE 2786
Query: 1847 HDIQALSPQV 1856
H I+ L Q+
Sbjct: 2787 HGIRLLEAQI 2796
Score = 115 bits (288), Expect = 5e-25
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 1134 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1189
Query: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 1190 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1248
Query: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 1249 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1308
Query: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 1309 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1358
Query: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
A A + + ++ +V +E QQ R + + + S S
Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1416
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 1417 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1473
Query: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1532
Query: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1592
Query: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1833 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949
Query: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2009
Query: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2049
Query: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109
Query: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2169
Query: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 2170 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2222
Query: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 2223 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2264
Query: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
AAR +VA Q A +L ++ALA ++ K
Sbjct: 2265 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2301
Query: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2350
Query: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 2351 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2404
Query: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 2405 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2450
Query: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 2451 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2505
Query: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2506 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Score = 106 bits (264), Expect = 3e-22
Identities = 327/1505 (21%), Positives = 556/1505 (36%), Gaps = 274/1505 (18%)
Query: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1350
Query: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 1351 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1399
Query: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
QK R I QE+L+QL ++ + +A R+
Sbjct: 1400 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1425
Query: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 1426 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1478
Query: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 1479 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1533
Query: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
R L E + + +A++ + A + + + ++ + L E VA
Sbjct: 1534 AERRLRQAE----VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1589
Query: 619 LEQSYEA---LCELAAARRARLEESRRLWRFLWEVGEA-----EAWVREQQHLLASADTG 670
+ EA + A A RAR E R L R+ + EA +A QQ LA A+
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649
Query: 671 RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL-QAQW 729
+ A R + RG+ A + + R EL + +
Sbjct: 1650 KQKEEAEREARR----RGK-------------------------AEEQAVRQRELAEQEL 1680
Query: 730 ERLEALAEERA-QRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
E+ LAE A QRLA L + +A+ E R + EL + A ++
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGE-----QQRQLLEEELARLQREAAAATQK 1735
Query: 789 HRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARAL 848
+ LE E+ R ++ L A E + R T E+ + L+A AG
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKA--------RAEEESR-STSEKSKQRLEAEAGRFRELA 1786
Query: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
E A L + EA K Q +L + + +QR E LA ++
Sbjct: 1787 EEAARLRALAEEA---------KRQ--------RQLAEEDAARQRAEA----ERVLAEKL 1825
Query: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
A+ + +A K++ E N R RRLA
Sbjct: 1826 AAIGEATRLKTEAEIALKEK-----EAENER---LRRLA--------------------- 1856
Query: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
E +A+ R + + E D+ LA RK + +E LE V + R+ +
Sbjct: 1857 EDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQV--- 1909
Query: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTA 1087
+ +A+ A + G +L E LG R +D LRS + + R +
Sbjct: 1910 -EEEILALKASFEKAAAGKAEL-------ELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961
Query: 1088 VASEEGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFL 1143
A EE EAE + + A E R A E RL+A EE R L
Sbjct: 1962 AAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------L 2010
Query: 1144 RQRLEALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM 1200
R+R E +L + E+ Q RL +AH F + ++ + L ++ VL ++
Sbjct: 2011 RERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QL 2065
Query: 1201 PGTLQAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIR 1250
G +AA A ++ E+ + ER+ E Q ++ A+K+R
Sbjct: 2066 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 1251 EKAD-SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYD 1307
++A+ RR + Q A +Q + + + F + K +++++ T Q D
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 1308 EARN-LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDL 1361
+N L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 2186 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2245
Query: 1362 HRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNIL 1421
L+ + + +A R + AQ L QL +D + +
Sbjct: 2246 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKM 2297
Query: 1422 LKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERC 1481
LK++ E + E E +Q Q K LAQE + R E+ + L + +
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQ 2351
Query: 1482 RRLQASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMK 1528
R L+A R+ Q + + E L V E + E G+ L +L +
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2411
Query: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLE 1585
+ TL + + +++ +Q A +AEL+ ++L E L+L+ + ++
Sbjct: 2412 EKVTLVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2463
Query: 1586 DALRAQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
+ Q A ++++ E Q + QEKAK E Q EV K Q L +
Sbjct: 2464 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2523
Query: 1641 AQTIHQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEH 1693
Q + Q L AS ++ +H + +Q ++ +L + EL E +RL+E
Sbjct: 2524 QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2583
Query: 1694 LRLCQ 1698
L+L +
Sbjct: 2584 LQLLE 2588
Score = 96.7 bits (239), Expect = 2e-19
Identities = 353/1719 (20%), Positives = 645/1719 (37%), Gaps = 237/1719 (13%)
Query: 529 LNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLL-QLHELVEADI-AVQAER 586
L L Q+ + +L L+ WM + + +E L Q + E ++ A +A++
Sbjct: 263 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 322
Query: 587 VR----------AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRAR 636
R AV A L+ PG Y P D V + KL + A+ E R+
Sbjct: 323 NRSKGIYQSLEGAVQAGQLKV-PPG--YHPLD---VEKEWGKL---HVAILEREKQLRSE 373
Query: 637 LEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRD--LTGALRLLNKHTALRGEMSGRL 694
E L R + ++ + EA + E+Q A A D L A ++ + + ++
Sbjct: 374 FERLECLQRIVTKL-QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 432
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL-----AQAASL 749
++L Q L HP Q R L ERL A+ E RL A A +
Sbjct: 433 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLH---ERLVAIRTEYNLRLKAGVAAPATQV 489
Query: 750 YQFQADA---------------NDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEE 794
Q + D+ AW+ + V E G D S +A HR L +
Sbjct: 490 AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ 549
Query: 795 EIRSHRPTLDALREQAAALPP-TLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA 853
I R ++ R L P T + GR L+ Y +L + R R+LE+
Sbjct: 550 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGR---LDLQYAKLLNSSKARLRSLES--- 603
Query: 854 LYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVND 913
L++ ++ A +W+ EKE+ G +R ++ ++ + L E+ +I + +
Sbjct: 604 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 663
Query: 914 IAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAW 973
++LL+ + P + + + Q L +W +L +A L + + + E +
Sbjct: 664 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQ 723
Query: 974 MREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT---REANA---LAA 1027
+++ + + A V L+ L + + E + G L+ + A A L
Sbjct: 724 LQKLQEALRRKYSCDRS-ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 782
Query: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREES--LGEARRLQDFLRSLDDFQAWLGRTQ 1085
HPA + L V ++ + T+ + +E +G A+ + S +A
Sbjct: 783 RHPAHPMRGRLPLLAV-CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA------ 835
Query: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
AV S P EA A V R ++++ L L ++ D +
Sbjct: 836 -AVPSVCFLVPPPNQEAQEA--------VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 886
Query: 1146 RLEALGTGWE----ELGRMWESRQGRLAQAHGFQGFLRDARQAEG------VLSSQEYVL 1195
R L W + E RQ + +Q FLRD++ A G +++ +EY
Sbjct: 887 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 946
Query: 1196 SHTEMPGTLQAADAA----------IKKLEDFMSTMDANGER-IHGLLEAGRQLVSEGNI 1244
LQ+ + I +L+D ++A R +H L +
Sbjct: 947 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP---------L 997
Query: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL------------QDCHELKL 1292
+ RE A I + K + G R + E + L + EL L
Sbjct: 998 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1057
Query: 1293 WIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E++ + + ++ + + + Q L A+++ L KE + + PEL+A
Sbjct: 1058 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLPELEA 1113
Query: 1353 LVS--EKLRDLHRRWDELETTTQAKARS-LFDANRAELFAQSCCALESWLESLQAQLHSD 1409
+ +KLR QA+A+ FDA R EL E LQ +
Sbjct: 1114 TKASLKKLR------------AQAEAQQPTFDALRDELRGAQEVG-----ERLQQRHGER 1156
Query: 1410 DYGKDLTSVNI--LLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVE 1467
D + + LL++ Q + + VR++E+E + Q + + G + +R +
Sbjct: 1157 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1216
Query: 1468 EKFRAL----CQPMRERCRRLQASREQHQFHRDVEDE-------------------ILWV 1504
E+ +A+ Q +RE+ R+ QA E+ + H + +E + +
Sbjct: 1217 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1276
Query: 1505 TERLPMASSME--------------------HGKDLPSV--QLLMKKNQTLQKEIQGHEP 1542
+ P+AS + H +L ++ Q + ++TL++ E
Sbjct: 1277 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR--MEEEE 1334
Query: 1543 RIADLR---ERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE 1599
R+A+ + ER+R AA + +L E + + E K L+ ++ + R+ A
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394
Query: 1600 AEAWMGEQELHM-MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
+A ++ + + Q + E QA+ ++ + E++ + I + + E
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR------LQLE 1448
Query: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
E R + ++ L A +E ++R+ +E RL RR++ D Q ++ EV A
Sbjct: 1449 ATERQRGGA-EGELQALRARAEEAEAQKRQAQEEAERL---RRQVQDESQRKRQAEVELA 1504
Query: 1719 SH-----ELGQDYEHVTMLRDKFREFSRDTST-IGQERVDSANALANGLIAGGHAARATV 1772
S E ++ + ++ R + + + Q V+ A + L +A A +
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1564
Query: 1773 AEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGR-D 1831
+ S E A L L +A +L+ Q A + +++ R
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 1832 LNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1891
L A EAL+ R A E Q Q + + ++A KAEE + +AE +
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1681
Query: 1892 LQGSSA-ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQ 1950
Q A Q L + +A E E Q+ +E R A + +Q
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRLRAETE----QGEQQRQLLEEELARLQREAAAATQKRQ 1737
Query: 1951 GIKAEI-EARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++AE+ + RA+ E+L S AEE S S+ +R E ++
Sbjct: 1738 ELEAELAKVRAEM---------EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788
Query: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA-VAWEER 2068
L L + + L ++ + AE + E + I + A +A +E+
Sbjct: 1789 AARLRALA---EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1845
Query: 2069 FCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASV 2107
E+L L E E ++R+ EE+ + + E A +
Sbjct: 1846 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1884
Score = 77.4 bits (189), Expect = 2e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 959 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1016
Query: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 1017 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1070
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1130
Query: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1131 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1191 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1248
Query: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1249 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1302
Query: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1303 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1359
Query: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1406
Query: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1407 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1461
Query: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1520
Query: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1521 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1573
Query: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1574 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1620
Query: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
+ ++ + Q++ +LA AE + EA +
Sbjct: 1621 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1661
Query: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1662 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711
Query: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1712 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1767
Query: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1768 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1827
Query: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1828 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1883
Query: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 1884 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940
Query: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 1941 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 422 bits (1086), Expect = e-117
Identities = 252/652 (38%), Positives = 368/652 (56%), Gaps = 43/652 (6%)
Query: 30 DSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGR 89
+ DWD D +E+ Q+KTFT W NSHL + ++ ++ D R+G
Sbjct: 30 EEDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIENIEEDFRNGL 77
Query: 90 NLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLT 149
L+ LLEV+SGE LP+P KG+MR H + NV+KAL F+ + V L ++G+ +IVDGN ++T
Sbjct: 78 KLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMT 137
Query: 150 LGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGL 209
LG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVNV NF TSW+DGL
Sbjct: 138 LGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGL 191
Query: 210 AFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED-VNVDQPDEKS 268
A A++H+HRPDL+D+ L+K + NL AF +AEK L + K+LD ED VN +PDEK+
Sbjct: 192 ALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKA 251
Query: 269 IITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTL 328
I+TYV+ +YH F+ + RI KVL E E+L+E+YE LASELL+WI +T+ L
Sbjct: 252 IMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWL 311
Query: 329 NDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPRE 388
+R S+S +Q +L+ F YR + KPP+ EK LE+ T+Q+KLR +++ + P E
Sbjct: 312 ENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSE 371
Query: 389 GRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV 448
G+L+SDI AW LE+ E E L +E+ R ++L+ LA +F +KA++ E W + ++
Sbjct: 372 GKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML 431
Query: 449 SQDNF-GLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
SQ ++ L V A +R+HEA E+D+ A+ RV+ + A+A EL YH+ + +R
Sbjct: 432 SQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQ 491
Query: 508 NVARLWDFLRQMVAARRERLLLNLELQKVFQDLLY--------LMDWMEEMKGRLQSQDL 559
+ WD L + RR+ L +L + L +W++ LQ L
Sbjct: 492 AICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWL 551
Query: 560 GRHLAGVEDLLQLHE-----LVEAD------IAVQAERVRAVSASALRFC--NPGKEYRP 606
+ + LL H+ L EAD + +Q E + LR C NP P
Sbjct: 552 VHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSP 611
Query: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVR 658
D + V KL S + + AR+ E RR +F + W++
Sbjct: 612 QDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRR--QFAAQANAIGPWIQ 661
Score = 58.2 bits (139), Expect = 1e-07
Identities = 82/401 (20%), Positives = 150/401 (37%), Gaps = 46/401 (11%)
Query: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
+++A +E L E +K+ +LL + W+E G + R L D +LH
Sbjct: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
Query: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSE------RVAKLEQSYEALC 627
+ Q E + LR + + P + +LVS+ + ++E+ YE
Sbjct: 338 KPPRIQEKCQLEINFNTLQTKLRLSHR-PAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
Query: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR-LLNKHTAL 686
R RL+ +F + EAW R ++ +L+ D L +R LL +H A
Sbjct: 397 LSEIRRLQRLQHLAE--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAF 454
Query: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+++ ++ Q+L + A+ ++R + QW+ L L ++R L +
Sbjct: 455 ESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERM 514
Query: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
L +F A WL A+ + L H TQ+L H ++ ++
Sbjct: 515 EKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH----DQFKA 570
Query: 799 HRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQAR------------AGERAR 846
P D R + + + + G P Y L + R +
Sbjct: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
Query: 847 ALEAALALYTM--------LSEAGACGLWVEEKEQWLNGLA 879
L+ LA + ++A A G W++ K + + LA
Sbjct: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLA 671
Score = 46.6 bits (109), Expect = 3e-04
Identities = 88/416 (21%), Positives = 160/416 (38%), Gaps = 84/416 (20%)
Query: 881 PERLEDLEVVQQRFETLEPEMNT------LAAQITAVNDIA------EQLLKANPPGKDR 928
P R+++ ++ F TL+ ++ + ++ V+DIA EQ+ K
Sbjct: 339 PPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLS 398
Query: 929 IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988
+ ++L H ++FR+ KA+L +AW R K +++
Sbjct: 399 EIRRLQRLQHLAEKFRQ-----KASLH---------------EAWTRGKEEMLSQRDYDS 438
Query: 989 NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048
L V AL R+ E DL A RV + A L +A ++N+R + + W+
Sbjct: 439 ALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWD 498
Query: 1049 DLRATMRRREESLGEARRL--------QDFLRSLDDFQAWLG----------------RT 1084
+L ++R ++L +L +F R F WL T
Sbjct: 499 NLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEET 558
Query: 1085 QTAV-ASEEGPATLPEAEALLAQHAALRGEVERAQSEYS-RLRALGEEVTRDQADPQCLF 1142
Q+ + A ++ ATLPEA+ ++GE+++ Y R + +T D
Sbjct: 559 QSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQD----- 613
Query: 1143 LRQRLEALGTGWEELGRMWESR----QGRLAQAHGFQGFLRD-ARQAEGV-----LSSQE 1192
+ T W+ + ++ SR Q LA+ + R A QA + +E
Sbjct: 614 -------INTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
Query: 1193 YVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK 1248
+ G+L+ A +++ E + N +R LE QL+ E + +K
Sbjct: 667 VGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR----LEGDHQLLQESLVFDNK 718
Score = 45.1 bits (105), Expect = 9e-04
Identities = 51/254 (20%), Positives = 101/254 (39%), Gaps = 15/254 (5%)
Query: 281 SKMKALAVEGKRIGKVLDHAMEA----ERLVEKYESLASELLQ-------WIEQTIVTLN 329
S+ +A+ + +G + +A E+L+E + L E + W++ + L
Sbjct: 488 SRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQ 547
Query: 330 DRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREG 389
D L +S+ Q+ L + + ++ P E+G + + IQ + + +
Sbjct: 548 DVWLVHSVEETQSLLTAHDQFKAT-LPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606
Query: 390 RLIS--DINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRL 447
+S DIN W+ + K R+ L+ EL RQ+ E+L +F +A W+
Sbjct: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
Query: 448 VSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
V + GL ++E + E +I+ Y + ++ L D K
Sbjct: 667 VGRLAAGL-AGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSME 725
Query: 508 NVARLWDFLRQMVA 521
++ W+ L +A
Sbjct: 726 HIRVGWEQLLTSIA 739
Score = 41.2 bits (95), Expect = 0.012
Identities = 42/176 (23%), Positives = 77/176 (43%), Gaps = 20/176 (11%)
Query: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQ------DCHELKLW 1293
SEG + +D I +E+ K +D L +R + QH + HE
Sbjct: 370 SEGKLVSD-IANAWRGLEQVEKGYED---WLLSEIRRLQRLQHLAEKFRQKASLHEAWTR 425
Query: 1294 IDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKAL 1353
E+ML+ +D + + ++H+AF ++LAA++D ++ + +EL A
Sbjct: 426 GKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAAS 485
Query: 1354 VSEKLRDLHRRWDELETTTQAKARSL---------FDANRAELFAQSCCALESWLE 1400
V+ + + + +WD L T TQ + +L D + E FA+ +WL+
Sbjct: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE-FARRAAPFNNWLD 540
Score = 39.3 bits (90), Expect = 0.047
Identities = 46/207 (22%), Positives = 85/207 (41%), Gaps = 35/207 (16%)
Query: 1879 GRHMQAVAEAWAQLQG----------SSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNL 1928
G+ + +A AW L+ S R Q L +KFR ++ E E L
Sbjct: 372 GKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML 431
Query: 1929 QMDAQERPRDVSSADL-----VIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEE 1983
RD SA L +++ + ++++ A DR + +EL ++ A
Sbjct: 432 SQ------RDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAAS 485
Query: 1984 ISEK----------LSQLQARRQETAEKWQEKMDWL-QLVLEVLVFGRDAGMAEAWLCSQ 2032
++ + L L +R++ E+ ++ ++ + QL LE F R A WL
Sbjct: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE---FARRAAPFNNWLDGA 542
Query: 2033 EPLVRSAELGCTVDEVESLIKRHEAFQ 2059
++ L +V+E +SL+ H+ F+
Sbjct: 543 VEDLQDVWLVHSVEETQSLLTAHDQFK 569
Score = 39.3 bits (90), Expect = 0.047
Identities = 47/182 (25%), Positives = 73/182 (40%), Gaps = 20/182 (10%)
Query: 1385 AELFAQSCCALESWLESLQAQLHSDDYGKD-LTSVNILLKKQQMLEWEMAVREKEVEAIQ 1443
AE F Q E+W + L DY L V LL++ + E ++A + VE I
Sbjct: 410 AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIA 469
Query: 1444 AQAKALAQED-QGAGEVERTSRAVEEKF---RALCQPMRERCRRLQASRE-----QHQFH 1494
A A+ L + D A V +A+ +++ L Q R+ R++ E Q +F
Sbjct: 470 ALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFA 529
Query: 1495 RDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL 1554
R W+ + +DL V L+ +T Q + H+ A L E R
Sbjct: 530 RRAAPFNNWLDGAV---------EDLQDVWLVHSVEET-QSLLTAHDQFKATLPEADRER 579
Query: 1555 GA 1556
GA
Sbjct: 580 GA 581
Score = 36.2 bits (82), Expect = 0.40
Identities = 29/100 (29%), Positives = 46/100 (46%), Gaps = 14/100 (14%)
Query: 1994 RRQETAEKWQEKMDWLQLVLEVLV--------FGRDAGMAEAWLCSQEPLVRSAEL-GCT 2044
R E EK E DWL + L F + A + EAW +E ++ +
Sbjct: 383 RGLEQVEKGYE--DWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSAL 440
Query: 2045 VDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKE 2084
+ EV +L++RHEAF+ A ++R +E + AL + E
Sbjct: 441 LQEVRALLRRHEAFESDLAAHQDR---VEHIAALAQELNE 477
Score = 34.7 bits (78), Expect = 1.2
Identities = 34/140 (24%), Positives = 57/140 (40%), Gaps = 12/140 (8%)
Query: 1793 RGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQAL 1852
R Q LA + + LH +A R + + D L AL RRH A+E D+ A
Sbjct: 405 RLQHLAEKFRQKASLH---EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
Query: 1853 SPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAW------AQLQGSSAARRQLLLDT 1906
+V+ + L + +A + QA+ + W Q + + R + LL+T
Sbjct: 462 QDRVEHIAALAQELNE-LDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLET 520
Query: 1907 TDKFR--FFKAVRELMLWMD 1924
D+ + F + W+D
Sbjct: 521 IDQLQLEFARRAAPFNNWLD 540
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
Length = 1369
Score = 351 bits (900), Expect = 6e-96
Identities = 338/1225 (27%), Positives = 527/1225 (43%), Gaps = 165/1225 (13%)
Query: 53 DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112
DER+ VQKKT TKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP+ KGRMR
Sbjct: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
Query: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V +
Sbjct: 230 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
Query: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232
E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D + +
Sbjct: 289 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
Query: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292
NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++ + +G R
Sbjct: 348 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
Query: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352
A E + ++Y L LLQW+ +R+ +S ++ F ++
Sbjct: 407 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
Query: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412
+E P K +K + + +++ ++A KV G D+ K W +L A ERE
Sbjct: 460 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516
Query: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472
LR+E R E L+++ + +A + E L + L+ D + L A ++ +E
Sbjct: 517 LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
Query: 473 D-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRE 525
D I VQ + + Y + R+ R + ++ + A
Sbjct: 574 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 633
Query: 526 RLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLLQLHEL 575
+ + LQ V + L YL D W+EE + R+ + G L VE L H
Sbjct: 634 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 693
Query: 576 VEADI-AVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARR 634
+ I QA+ RA S YR C + +L+ Y +L + +
Sbjct: 694 LHQSIEEFQAKIERARSDEGQLSPATRGAYRDC--------LGRLDLQY---AKLLNSSK 742
Query: 635 ARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRL 694
ARL L F+ + W+ E++ D T ++AL E+ +
Sbjct: 743 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 802
Query: 695 GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQA 754
+K G +L+ E HP + A LQ QW + L L + A+ +QF +
Sbjct: 803 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 862
Query: 755 DANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAA 811
D + E L +ALR +S + + L + + +E++ ++ L L ++A
Sbjct: 863 DVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK 922
Query: 812 ALPPTLSRTP--EVQGRVPTL---ERHYEELQARAGERARAL-EAALALYTMLSEAGA-- 863
A+ R P ++GR+P L + E+ G+ + + A + + +LS +G+
Sbjct: 923 AVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA 982
Query: 864 ------------------------------CGLWVEEKEQWLNGLALPERLEDLEVVQQ- 892
LW + + LA D+++++
Sbjct: 983 AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
Query: 893 ---RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE--QLNHRWQQ-F 943
F TL+PE A ++ A + G +DR++ +E +H +QQ
Sbjct: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
Query: 944 RRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------------EKTKV 980
+ L G + S L LE ET+ R E+ K
Sbjct: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKA 1162
Query: 981 IESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANALAAGHPAQAV 1034
+GLG +A + A K+ A EL + +L+A + +
Sbjct: 1163 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1222
Query: 1035 AINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGP 1094
I+ +R Q E LRA EE L EA+ + P
Sbjct: 1223 TISLVIRGTQGAEEVLRA----HEEQLKEAQAV--------------------------P 1252
Query: 1095 ATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQADPQCLFLRQ 1145
ATLPE EA A LR + E Q + LR +GE + + + D + R+
Sbjct: 1253 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1312
Query: 1146 RLEALGTGWEELGRMWESRQGRLAQ 1170
R+ L W+ + + RQ L Q
Sbjct: 1313 RVAQLLERWQAVLAQTDVRQRELEQ 1337
Score = 54.3 bits (129), Expect = 1e-06
Identities = 163/819 (19%), Positives = 299/819 (36%), Gaps = 151/819 (18%)
Query: 1289 ELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP 1348
+L LW + Q + D N + W+ + F A + +K L ++K R+ LE
Sbjct: 296 KLLLWSQRMVEGYQGLRCD---NFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352
Query: 1349 ELKALVSEKLRDLHRRWDEL--------ETTTQAKARSLFDA-------------NRAEL 1387
+ V+E+ + R D E + SL+DA N +L
Sbjct: 353 DQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQL 412
Query: 1388 ----FAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE--- 1440
+ + L W+ A + + IL W ++ KE+E
Sbjct: 413 RWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL--------WSQFLKFKEMELPA 464
Query: 1441 --AIQAQAKALAQEDQGAGEVERTSRA-------VEEKFRALCQPMRERCRRLQASREQ- 1490
A + ++K + Q +GA + + VE+++ L + ER ++L++ E+
Sbjct: 465 KEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL 524
Query: 1491 ---------------------HQFHRDVEDEI-LWVTERLPM-ASSMEHGKDLPS--VQL 1525
HQ ++ +I L ++P A +E D ++L
Sbjct: 525 ECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRL 584
Query: 1526 LMKKNQTLQ--KEIQG----------HEPRIADLRERQRALGAAAAGPELAELQEMWKRL 1573
L QTL+ + QG HE +A E L A A P Q + +
Sbjct: 585 LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSV 644
Query: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVL 1633
EL L R + AW+ E + + G E D S +A++ H+ L
Sbjct: 645 QRRPELEDSTL----------RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGL 694
Query: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQA--QVDKLYAGLKELAGERRERLQ 1691
Q++ ++ I + A S + + +TR + R ++D YA L + R L+
Sbjct: 695 HQSIEEFQAKIER-ARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 749
Query: 1692 E-HLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQER 1750
H + +EL W+ E+E + ++T ++ + R+ + +++
Sbjct: 750 SLHSFVAAATKEL----MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE-LKEKK 804
Query: 1751 VDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGA 1810
+ + L+ H AR TV ++ +L W+ +L+L L +F
Sbjct: 805 IKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDV 864
Query: 1811 RQALARVQHKQQQLPDGTGRDLNAAEALQRRH-CAYEHDIQALSPQVQQVQDDGHRLQKA 1869
R+A ++Q Q EAL+R++ C + L +Q QD+ +L +
Sbjct: 865 REAEGQLQKLQ--------------EALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNE- 909
Query: 1870 YAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQ 1929
Y G + + +AV + + R LL D +K V + DE L
Sbjct: 910 YKG-HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCD----YKQVEVTVHKGDECQLV 964
Query: 1930 MDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLS 1989
AQ V S+ G +A + S C + +E+ E ++
Sbjct: 965 GPAQPSHWKVLSS-------SGSEAAVP------SVCFLVPP--------PNQEVQEAVT 1003
Query: 1990 QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAW 2028
+L+A+ Q W + ++ +L RD + +W
Sbjct: 1004 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
Score = 43.1 bits (100), Expect = 0.003
Identities = 142/732 (19%), Positives = 252/732 (34%), Gaps = 118/732 (16%)
Query: 1071 LRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEE 1130
LR L D AW+ Q V E LP EA L H L +E Q++ R R+
Sbjct: 655 LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS---- 710
Query: 1131 VTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSS 1190
D+ + LG + ++ S + RL F+ A + L+
Sbjct: 711 ---DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNE 767
Query: 1191 QE-------YVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGN 1243
+E + +T M ++ A +++LE ++I L AG +L+ E +
Sbjct: 768 KEEEEVGFDWSDRNTNMTAKKESYSALMRELE-------LKEKKIKELQNAGDRLLREDH 820
Query: 1244 IHADKIREKADSIERR-------------HKKNQDAAQQFLGRLRDNREQQHFLQDCHEL 1290
+ +++ + H K A QF +R+ Q LQ+
Sbjct: 821 PARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRR 880
Query: 1291 KLWIDEKMLTAQ-----DVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTL 1345
K D + + DE L+ +++ H + +A+ A L K +
Sbjct: 881 KNSCDRSATVTRLEDLLQDAQDEKEQLN-EYKGHLSGLAKRAKAVVQL-KPRHPAHPMRG 938
Query: 1346 EKPELKALVSEKLRDLHRRWDELETTTQAKAR--SLFDANRAELFAQSCC---------- 1393
P L +++ + DE + A+ + ++ +E S C
Sbjct: 939 RLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEV 998
Query: 1394 --------ALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML-EWEMAV--------RE 1436
A L +L QLH D K L + L + Q++ W +A +
Sbjct: 999 QEAVTRLEAQHQALVTLWHQLHVD--MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 1056
Query: 1437 KEVEAIQAQAKALAQEDQGAG------------EVERTSRAVEEKFRALCQPMRERCRRL 1484
+ + +++ +A ++ Q AG E S ++ ++L Q +E R
Sbjct: 1057 QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQ 1116
Query: 1485 QASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRI 1544
+ E +E RL + E ++ + + Q Q E++G +
Sbjct: 1117 RCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQAEVEGLGKGV 1173
Query: 1545 ADL-RERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA--- 1600
A L E ++ L P L+ ELEL +LE Y + +
Sbjct: 1174 ARLSAEAEKVLALPEPSPAAPTLRS-------ELELTLGKLEQVRSLSAIYLEKLKTISL 1226
Query: 1601 --EAWMGEQELHMMGQEKAKD---------ELSA--------QAEVKKHQVLEQALADYA 1641
G +E+ +E+ K+ EL A +A+ + Q AL D
Sbjct: 1227 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1286
Query: 1642 QTIHQLAASSQDMIDHEHPESTRISIRQAQ-VDKLYAGLKELAGERRERLQEHLRLCQLR 1700
+ ++ Q E R R AQ +++ A L + +RE Q +L R
Sbjct: 1287 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1346
Query: 1701 RELDDLEQWIQE 1712
D L W+Q+
Sbjct: 1347 ESADPLGAWLQD 1358
Score = 39.7 bits (91), Expect = 0.036
Identities = 88/420 (20%), Positives = 151/420 (35%), Gaps = 42/420 (10%)
Query: 827 VPTLERHYEELQARAG-ERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPE-RL 884
V LER E Q R+ ER L+ + M EAG C EE+ + L + RL
Sbjct: 508 VAILER---EKQLRSEFERLECLQRIVTKLQM--EAGLC----EEQLHQADALLQSDIRL 558
Query: 885 EDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFR 944
V QR +E +++ + I + + + L P +++ +L+ R R
Sbjct: 559 LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 618
Query: 945 -----RLADGKKAALTSALSIQNYHLE------------CTETQAWMREKTKVIESTQGL 987
RL G A T + ++ + AW+ E ++ +
Sbjct: 619 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW- 677
Query: 988 GNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGW 1047
G DL V A G + +E A++ + L+ PA A L + +
Sbjct: 678 GVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLS---PATRGAYRDCLGRLDLQY 734
Query: 1048 EDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQH 1107
L + + R SL L F+ + WL + + A +
Sbjct: 735 AKLLNSSKARLRSL---ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 791
Query: 1108 AALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGR 1167
+AL E+E + + L+ G+ + R+ P + AL T W + ++ +
Sbjct: 792 SALMRELELKEKKIKELQNAGDRLLRED-HPARPTVESFQAALQTQWSWMLQLCCCIEAH 850
Query: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGER 1227
L + + F D R+AEG L + L A + +LED + DA E+
Sbjct: 851 LKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCD----RSATVTRLEDLL--QDAQDEK 904
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 315 bits (806), Expect = 4e-85
Identities = 182/406 (44%), Positives = 250/406 (61%), Gaps = 15/406 (3%)
Query: 51 LADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGR 110
+ADER+ VQKKTFTKW+N HL +V V DLY DLRDG NL+ LLEVLSG+ LP+ KGR
Sbjct: 58 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 116
Query: 111 MRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETE 170
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V E
Sbjct: 117 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 176
Query: 171 DNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKK 230
E SAK+ LLLW Q T GY + NFTT WRDG FNAI+HK+RPDL+D ++
Sbjct: 177 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 234
Query: 231 CNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEG 290
+ NL++AF +AEK +G+ +LLDPEDV+V PDEKS+ITYV++ Y F K+ G
Sbjct: 235 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 290
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSY 350
+ IG A + E +Y+++ + L+QWI + T+++R N+ ++ + +
Sbjct: 291 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 345
Query: 351 RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERE 410
+ E PPK TEK ++ L ++ + K+ +G +DI K W +L A ERE
Sbjct: 346 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 402
Query: 411 LALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLE 456
ALR E+ R E L+Q+A R R + + E L + D+ LE
Sbjct: 403 KALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE 448
Score = 159 bits (403), Expect = 2e-38
Identities = 343/1769 (19%), Positives = 687/1769 (38%), Gaps = 166/1769 (9%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTI-VTLNDRQLANSLSGVQNQLQSFNS 349
K++ + EA +++ LL W+ T + N + + V+ Q+Q
Sbjct: 3321 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL 3380
Query: 350 YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHER 409
+ + K T +EV+ + +K+ T E +D K ++L +
Sbjct: 3381 LQRLLDDRKST----VEVI--------KREGEKIATTAEP---ADKVKILKQLSLLDSRW 3425
Query: 410 ELALRTELIRQEKLEQL---AARFDRKAAMRETWLSE-NQRLVSQDNFGLELAAVEAAVR 465
E L R +LE + A +F WL+ +RLV+ + G + + +E +
Sbjct: 3426 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3485
Query: 466 KHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDF-LRQMVAARR 524
+H+A+E DI+ ++ + ++ L + K + + + +++W +++ +R
Sbjct: 3486 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3545
Query: 525 ERLLLNLELQKVF-QDLLYLMDWMEEMKGRLQSQDLGRHLA-GVEDLLQLHELVEADIAV 582
E L L K+F +D + LM+W+ E+ +L + + G+ +++ DI +
Sbjct: 3546 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3605
Query: 583 QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642
+ + V + L K+ + ++ +++ ++ Y+ + +L+ LE++ +
Sbjct: 3606 RKQNVDQALLNGLELL---KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3662
Query: 643 LWRFLWEVGEAEA-WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTL 701
L R L E W+ + + L S +T ++L A + +M R LK
Sbjct: 3663 LARRLHSTHEELCTWLDKVEVELLSYET--------QVLKGEEASQAQM--RPKELKKEA 3712
Query: 702 EQGQQLVAEGHPGASQASARAAELQAQW---ERLEALAEERAQRLA-------------Q 745
+ + L+ ++ S+ EL W E LE + E +R
Sbjct: 3713 KNNKALL----DSLNEVSSALLEL-VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3767
Query: 746 AASLYQFQAD-ANDME-AWLVDA-LRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPT 802
AA L Q D A D E +W+ + +L+S ++ ++ T A + + EI H+
Sbjct: 3768 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3827
Query: 803 LDALREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSE 860
+D L + + S + ++ ++ + ++Y+ + ER LE A +L E
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3887
Query: 861 A-GACGLWVEEKEQWLNGLALPE-RLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918
W+ E + ++ L P E L Q+ L + I +N QL
Sbjct: 3888 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3947
Query: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN-YHLECTETQAWMREK 977
L+ +P I + + Q + + AL A+S +H + + +
Sbjct: 3948 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LESL 4004
Query: 978 TKVIESTQGLGNDLAGVLALQRKLAGTER---DLEAIAARVGELTREANALAA-----GH 1029
+++E + + A V ++ +++ + D+E + L + + A
Sbjct: 4005 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4064
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQD-FLRSLDDFQAWLGRTQTAV 1088
A A+ +L ++ WE++ + RE L + L + F + TQ +
Sbjct: 4065 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4124
Query: 1089 ASEEGPATLPEAEALLAQHA-ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147
E P P + A +R E++ Q E + LG E+ +P +++ +
Sbjct: 4125 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4184
Query: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA--EGVLSSQEYVLSHTEMPGTLQ 1205
+ L + W+ L + W+ R +L +A +D QA + V + + S + + L+
Sbjct: 4185 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4244
Query: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK---------IREKADSI 1256
I++L+ F S + L L+ + +DK ++ DS+
Sbjct: 4245 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4304
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWI--DEKMLTAQDVSYDEARNLHT 1314
E R Q + G L + QH L EL W+ E +L+ Q + + +
Sbjct: 4305 EERIINRQHKLE---GALLALGQFQHALD---ELLAWLTHTEGLLSEQKPVGGDPKAIEI 4358
Query: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP-ELKALVSEKLRDLHRRWDE-LETTT 1372
+ KH ++ A++ ++ V+K G +L E + + KL L++RW LE T
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4418
Query: 1373 QAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEM 1432
Q K + +A+ F L+ WL + L + K L + K+Q + E+
Sbjct: 4419 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVHMEV 4475
Query: 1433 AVREKEVEAIQAQAKALAQEDQ---------GAGEVERTSRAVEEKFRALCQPMRERCRR 1483
EA + K+L Q+ Q +++ ++EK+ ++ + ER +
Sbjct: 4476 CA---AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4532
Query: 1484 L-QASREQHQFHRDVEDEILWVTE-RLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHE 1541
L +A +FH ++D I W+T+ + + L +V + +++ E+ H
Sbjct: 4533 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4592
Query: 1542 PRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDA-LRAQQF 1593
+I +L + L + + L +Q W+++ L RG+ L+DA RA+QF
Sbjct: 4593 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4652
Query: 1594 YRDAAEAEAWMGEQELHMMGQ-EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQ 1652
+ ++ W+ E E + + E A D + ++ +H+ +++L + +
Sbjct: 4653 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4712
Query: 1653 DMIDHEHPESTRISIRQAQVDKLYAGLKE----LAG---ERRERLQEHLRLC-QLRRELD 1704
+ E T ++ ++D + + L++ + G ER+ +L+E L Q L
Sbjct: 4713 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQ 4767
Query: 1705 DLEQWIQERE-VVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL---ANG 1760
L W+ E +A + D + V L D + F ++ +R S AL A
Sbjct: 4768 ALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELG----KRTSSVQALKRSARE 4823
Query: 1761 LIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHK 1820
LI G + V L+ W + L ++ L AA H AL +
Sbjct: 4824 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE 4883
Query: 1821 QQQ-------LPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
+Q LPD D +A L +H + ++ ++ + G + D
Sbjct: 4884 AEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4939
Query: 1874 KAEEIGRHMQAVAE------AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927
I + + AWA+ A L K +A+ + W +
Sbjct: 4940 SITTIKHWITIIRARFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTL 4997
Query: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEI 1956
D + P+++ +I Q E+
Sbjct: 4998 TDKDKEVIPQEIEEVKALIAEHQTFMEEM 5026
Score = 129 bits (325), Expect = 3e-29
Identities = 339/1876 (18%), Positives = 719/1876 (38%), Gaps = 160/1876 (8%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLN---DRQLANSLSGVQNQL--Q 345
K+ K+LD A E VE E +++ + L + + + G++ + Q
Sbjct: 3203 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3262
Query: 346 SFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKA 405
N ++ +K +G + + + Q +++ + T + D+N W+ L K
Sbjct: 3263 QLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK 3322
Query: 406 EHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV-SQDNFGLELAAVEAAV 464
+R L+ L+ RF +W+ + + LV +Q E V+A +
Sbjct: 3323 VAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQI 3375
Query: 465 RKHEAIETDIVAYSGRVQAVDAVAAELA--AERYHDIKRIAARQHNVARLWDFLRQMVAA 522
++ + ++ + V+ + ++A AE +K I + + W+ L
Sbjct: 3376 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSRWEALLNKAET 3434
Query: 523 RRERLL-LNLELQKVFQDLLYLMDWMEEMKGRL-QSQDLGRHLAGVEDLLQLHELVEADI 580
R +L +++ Q+ + L L +W+ ++ RL + +G + +E+ + H+ +E DI
Sbjct: 3435 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3494
Query: 581 AVQAERV-RAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEE 639
+ + +AVS +E D +V ++ + Y + E + +R L++
Sbjct: 3495 INHNKHLHQAVSIGQSLKVLSSRE----DKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3550
Query: 640 SRRLWRFLWE-VGEAEAWVREQQHLLASADTGRDLT-------GALRLLNKHTALRGE-- 689
+ + E E W+ E L+ T LR+L + LR +
Sbjct: 3551 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3610
Query: 690 ---MSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+ L LK T ++ + + ++A+++ + L+ + A+ L QA
Sbjct: 3611 DQALLNGLELLKQTTGDEVLIIQD----------KLEAIKARYKDITKLSTDVAKTLEQA 3660
Query: 747 ASL-YQFQADANDMEAWL--VDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803
L + + ++ WL V+ L ++ E ++QA R + L++E ++++ L
Sbjct: 3661 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNNKALL 3719
Query: 804 DALREQAAALPPTLS-RTPE-VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861
D+L E ++AL + R E ++ V Y + ++ ++AA+ +A
Sbjct: 3720 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3779
Query: 862 GACGL-WVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK 920
L W+ E E+ L L D+ + Q + T +I DI + L+K
Sbjct: 3780 ADAELSWITETEKKLMSLG------DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3833
Query: 921 A--------NPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC-TETQ 971
+ + K + +++ + ++ + L A S+ N E E
Sbjct: 3834 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3893
Query: 972 AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
W+ E +I + + Q + + + ++ + L P
Sbjct: 3894 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3953
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEA-RRLQDFLRSLDDFQAWLGRTQTAVAS 1090
+ +I + T + ++ +++R +L EA + F +D L R +
Sbjct: 3954 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL-- 4011
Query: 1091 EEGPATLPEAEAL---LAQHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFL 1143
+ P+ E E + ++++ + ++E+ Q Y L+ GEE+ D +
Sbjct: 4012 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4071
Query: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGF-QGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
+ +L+ + WE + + E R+ +L + F D + + + E PG
Sbjct: 4072 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4131
Query: 1203 -----TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSE-GNIHADKIREKADSI 1256
Q +AA E +D E + ++ G +L++ G +++ D +
Sbjct: 4132 IDPSVVKQQQEAA----ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4187
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKL-WID---EKMLTAQDVSYDEARNL 1312
A + + +L + + QD + W+D K+ + + D +
Sbjct: 4188 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD-LETV 4246
Query: 1313 HTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK---PELKALVSEKLRDLHRRWDELE 1369
+ ++ + F +E + +++++ + EL L+K K V + L +L WD LE
Sbjct: 4247 KQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4305
Query: 1370 TTTQAKARSLFDANRA-ELFAQSCCALESWLESLQAQL-HSDDYGKDLTSVNILLKKQQM 1427
+ L A A F + L +WL + L G D ++ I L K +
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4365
Query: 1428 LEWEMAVREKEVEAIQAQAKALAQEDQG--AGEVERTSRAVEEKFRALCQPMRERCRRLQ 1485
L+ ++ + VEA+ L + G A ++ + ++++ + + +R ++L
Sbjct: 4366 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4425
Query: 1486 -ASREQHQFHRDVEDEILWVTE-------RLPMASSMEHGKDLPSVQL-----LMKKNQT 1532
A R+ FH ++ED W+T+ P+ E K+ +V + K +T
Sbjct: 4426 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4485
Query: 1533 LQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQ 1591
+ +Q + +A R ++ L+E W+ + +L R +LE+AL A
Sbjct: 4486 YKSLMQKGQQMLA----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4541
Query: 1592 QFYRDAAEAEAWM--GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAA 1649
+F+ + W+ EQ L++ + + + ++ +H+V + + + I +L
Sbjct: 4542 EFHNSLQDFINWLTQAEQTLNVASRPSLILD-TVLFQIDEHKVFANEVNSHREQIIELDK 4600
Query: 1650 SSQDM-IDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLE 1707
+ + + + I V + + + ER L + R Q L
Sbjct: 4601 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4660
Query: 1708 QWIQEREVVAASH-ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGH 1766
+W++E E S E+ D + + + +EF + D+ N L
Sbjct: 4661 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA-KHSVYDTTNRTGRSL----- 4714
Query: 1767 AARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPD 1826
+ ++A+ L++ ++L + DT + + E Q L A + Q L D
Sbjct: 4715 KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDALQALID 4771
Query: 1827 GTGR-------------DLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
R D++ L H A++ ++ + VQ ++ L + + D
Sbjct: 4772 WLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRD 4830
Query: 1874 KAEEIGRHMQAVAEAW---AQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQM 1930
+ + MQ ++ W L S R + L ++F V L+ W+ E +
Sbjct: 4831 DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFH--SVVHALLEWLAEAEQTL 4888
Query: 1931 DAQ-ERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSH-YAAEEISEKL 1988
P D + +I + ++E + + MG +LA H + I +
Sbjct: 4889 RFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWI 4948
Query: 1989 SQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMA-EAWLCSQEPLVRSAE---LGCT 2044
+ ++AR +E ++ L L L+ ++ A AWL E + + +
Sbjct: 4949 TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE 5008
Query: 2045 VDEVESLIKRHEAFQK 2060
++EV++LI H+ F +
Sbjct: 5009 IEEVKALIAEHQTFME 5024
Score = 118 bits (296), Expect = 6e-26
Identities = 206/1008 (20%), Positives = 403/1008 (39%), Gaps = 91/1008 (9%)
Query: 399 WERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-DNFGLEL 457
WE + ERE L + +LA +F + + Q + ++ G++
Sbjct: 4082 WENIHTLVEEREAKLLDVM-------ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4134
Query: 458 AAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQ-HNVARLWDFL 516
+ V+ E I +I + V + +EL A K I + + WD L
Sbjct: 4135 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4194
Query: 517 RQMVAARRERLLLNLELQKVFQD-LLYLMDWMEEMKGRLQSQD-LGRHLAGVEDLLQLHE 574
+ R ++L ++ +QD L + DW++ G+L S +G L V+ ++ +
Sbjct: 4195 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4254
Query: 575 LVEADI---AVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
+++ ++ ER+ + L+ K D V + + +L+ +++L E
Sbjct: 4255 QFKSEAYQQQIEMERLNHQAELLLK-----KVTEESDKHTVQDPLMELKLIWDSLEERII 4309
Query: 632 ARRARLEESR-RLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTALRGE 689
R+ +LE + L +F + E AW+ + LL+ G D L KH L+ +
Sbjct: 4310 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4369
Query: 690 MSGRLGPLKLTLEQGQQLVAEGHPG--ASQASARAAELQAQWERLEALAEERAQRLAQAA 747
+ ++ + G L+ E G AS + L +W+ + E+R Q+L A
Sbjct: 4370 VLAHQSTVEAVNKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4428
Query: 748 SLYQ-FQADANDMEAWLVDALR-LVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDA 805
+ F + D++ WL D R L++S LG + + H + + T +
Sbjct: 4429 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4488
Query: 806 LREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGA 863
L ++ + ++ E + + L+ +E ++ + ER LE AL L +
Sbjct: 4489 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQ 4548
Query: 864 CGL-WVEEKEQWLNGLALPERLEDLEVVQ-QRFETLEPEMNTLAAQITAVNDIAEQLLKA 921
+ W+ + EQ LN + P + D + Q + E+N+ QI ++ L K
Sbjct: 4549 DFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL-KY 4607
Query: 922 NPPGKDRIV--NTQEQLNHRWQQF-RRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978
+D ++ N + RW++ +RL + ++ + + +H ++ W+ E
Sbjct: 4608 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4667
Query: 979 KVIESTQGLGND-------LAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
K ++S + ND LA Q+ L G + + R G +E +LA +
Sbjct: 4668 KSLDSELEIANDPDKIKTQLAQHKEFQKSL-GAKHSVYDTTNRTGRSLKEKTSLADDN-- 4724
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEAR----RLQDFLRSLDDFQAWLGRTQTA 1087
+ ++ L E++ W+ + R+ L EA + D L++L D WL R +
Sbjct: 4725 --LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID---WLYRVEPQ 4779
Query: 1088 VASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQR 1146
+A ++ + L+ H A + E+ + S L+ E+ D +++ +
Sbjct: 4780 LAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WVKVQ 4838
Query: 1147 LEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL--------SSQEYVLSHT 1198
++ L T WE + + S+Q RL A LR A + V+ +++ + H
Sbjct: 4839 MQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEAEQTLRFHG 4892
Query: 1199 EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKI--------- 1249
+P A I + ++FM ++ ++ G +++ H D I
Sbjct: 4893 VLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI--CHPDSITTIKHWITI 4950
Query: 1250 -REKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWID--EKMLTAQD--V 1304
R + + + K++Q Q+ L +Q L+ L W+ E LT +D V
Sbjct: 4951 IRARFEEVLAWAKQHQ---QRLASALAGLIAKQELLE---ALLAWLQWAETTLTDKDKEV 5004
Query: 1305 SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E + +HQ FM E+ + +DKV K + + L++
Sbjct: 5005 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5052
Score = 110 bits (275), Expect = 2e-23
Identities = 361/1905 (18%), Positives = 719/1905 (37%), Gaps = 278/1905 (14%)
Query: 362 KGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQE 421
K EVLL S L A N T + DI +E L K+ +ER L+ L R
Sbjct: 2050 KKTAEVLLDARGSLLPAKNDIQKT------LDDIVGRYEDLSKSVNERNEKLQITLTRSL 2103
Query: 422 KLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRV 481
++ D M + + L Q L A++ + K+ +E DI +
Sbjct: 2104 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2157
Query: 482 QAVDAVAAEL--------AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLEL 533
A++ + A+ +K ++AR + + A+ E L +EL
Sbjct: 2158 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK----HKETLAKMEELKTKVEL 2213
Query: 534 QKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSAS 593
F++L + E K +Q L +D+ +L + ++ + E + +
Sbjct: 2214 ---FENLSEKLQTFLETK----TQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVL 2266
Query: 594 ALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESR-RLWRFLWEVGE 652
P D LV E+ L + ++ + + ++ + + +L F V
Sbjct: 2267 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2326
Query: 653 AEAWVREQ-------QHLLASADTGRDLTGALRLLNKHTALRGEM--------------S 691
++W++E Q + D G+ L +L K + E+ S
Sbjct: 2327 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2386
Query: 692 GRLGPLKLTL---EQGQQLVAEG----------HPGASQASARAAELQAQWERLEALAEE 738
P K G L EG + G + ++ +E L L ++
Sbjct: 2387 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2446
Query: 739 RAQRL-AQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL---ARQHRALEE 794
+ L + + L + Q +++ M WL + + + T+A+ Q+++ E
Sbjct: 2447 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA 2506
Query: 795 EIRSHRPTLDALREQAAALPPTLSRTPEV---QGRVPTLERHYEELQARAGERARALEAA 851
E++ + + L+++ L TPE + + ++ ++EL +R + LE +
Sbjct: 2507 ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES 2566
Query: 852 LALYTMLSEAGA-CGLWVEEKEQWLNGLA--------LPERLEDLEVVQQRFETLEPEMN 902
T A W+ EKE ++ L L + + ++++ Q F T +P+
Sbjct: 2567 SNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE 2626
Query: 903 TLAAQITAVNDIAEQLLKANPPGKDRIVN--TQEQLNHRWQQFRRLADGKKAALTSALS- 959
L A + + PG+D + +EQL Q++ +LT LS
Sbjct: 2627 QLTAAGQGI---------LSRPGEDPSLRGIVKEQLAAVTQKWD--------SLTGQLSD 2669
Query: 960 ----IQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARV 1015
I ++ T+ Q+ +R + + L N L+ LA+ + LE
Sbjct: 2670 RCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK 2726
Query: 1016 GELTREANALAAGHPAQAVA--INARLREVQTGWEDLRATMRRREESL------------ 1061
E+ +E + AQA+ ++A ++E E L+A + R+ E +
Sbjct: 2727 QEIQQEKKQIKV---AQALCEDLSALVKE-----EYLKAELSRQLEGILKSFKDVEQKAE 2778
Query: 1062 GEARRLQD-------FLRSLDDFQAWLGRTQTAVASEEGP--ATLPEAEALLAQHAALRG 1112
+ LQ F + DFQAWL T+ ++ P A L E+L+ H
Sbjct: 2779 NHVQHLQSACASSHQFQQMSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2837
Query: 1113 EVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAH 1172
+ Y + A GE + + L+ +L + T W+ + + R+ +L ++
Sbjct: 2838 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES- 2896
Query: 1173 GFQGFLRDARQAEGV----------LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMD 1222
+ L+ Q E + L ++ L E ++ + K+++ ++
Sbjct: 2897 -LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 2955
Query: 1223 ANGERIHGLL---EAGRQLVSEGNIHADKIREKADSI-ERRHKKN---QDAAQQFLGRLR 1275
+ LL E +++V++ N + +K D + E+ H K ++ Q+F
Sbjct: 2956 LLNNTANSLLSVCEIDKEVVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE 3012
Query: 1276 DNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQ-----KHQAFMAELAANK 1330
++E + LQ C + +L I + L +Q S L T+ + KHQ +A+ A
Sbjct: 3013 VSKESKRQLQ-CAKEQLDIHDS-LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3070
Query: 1331 DWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDE----LETTTQA------KARSLF 1380
++ D +G L + E ++++ L ++ DE LET Q R +F
Sbjct: 3071 LVVEASDSKGTSDVLLQVE---TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMF 3127
Query: 1381 D---------------ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQ 1425
AE + ++++L+ L+A + S+D + + ++
Sbjct: 3128 SQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 3187
Query: 1426 QMLEWEMAVREKEVEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRL 1484
++ ++++EA+ Q L Q E VE T + +EE + L +E L
Sbjct: 3188 SP---DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL----KEFSILL 3240
Query: 1485 QASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRI 1544
Q + E + V E + ++L M + ++ L K Q + QG
Sbjct: 3241 QKAEEHEESQGPVGMETETINQQLNMFKVFQK----EEIEPLQGKQQDVNWLGQGL---- 3292
Query: 1545 ADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAW 1603
++ ++ +L ++ WK L ++ R +L++AL ++DA E+ +W
Sbjct: 3293 --IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3350
Query: 1604 MGEQELHMMGQEKAKDELS-AQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-E 1661
M + E + Q+ E +A++++ ++L++ L D T+ + + + P +
Sbjct: 3351 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3410
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC--QLRRELDDLEQWIQ--EREVVA 1717
+I + + +D + L A E R R E + + Q L+ L +W+ E+ +V
Sbjct: 3411 KVKILKQLSLLDSRWEALLNKA-ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLV- 3468
Query: 1718 ASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKD 1777
+ E + K E + + ++ L + G + E KD
Sbjct: 3469 -------NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3521
Query: 1778 ------SLNEAW-ADLLELLDTRGQVLAAA-----------YELQRFLHGARQALARVQH 1819
++ W ++ E +R ++L A EL +L+ L+++
Sbjct: 3522 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS- 3580
Query: 1820 KQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879
Q +G + + LQ DI V Q +G L K GD+ I
Sbjct: 3581 VQDYSTEGLWKQQSELRVLQ-------EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3633
Query: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAV-RELMLWMDEVNLQMDAQE---- 1934
++A+ + + S + L R + EL W+D+V +++ + E
Sbjct: 3634 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVL 3693
Query: 1935 RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQAR 1994
+ + S A + K +K E + S ++ LL + A E EK+
Sbjct: 3694 KGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE 3750
Query: 1995 R----QETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLC-SQEPLVRSAELGCTVDEVE 2049
R +T + E++D +L F + A +W+ +++ L+ ++ D+
Sbjct: 3751 RYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3808
Query: 2050 SLIKRHEAFQKSAVAWEERFCALEK-----LTALEEREKERKRKR 2089
+ ++ + F + ++ L K +TA E EK+ +K+
Sbjct: 3809 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3853
Score = 108 bits (269), Expect = 8e-23
Identities = 343/1970 (17%), Positives = 756/1970 (38%), Gaps = 251/1970 (12%)
Query: 252 KLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGK--VLDHAMEAERLVEK 309
K L+ E+ ++++ ++K + + S + + ++ GK + +E + K
Sbjct: 1455 KRLEEEEKSLEE-EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1513
Query: 310 YESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFN-SYR-----TVEKPPKFTEKG 363
E L SE LQ I+ + D+ + ++ Q+++ SY ++++ + G
Sbjct: 1514 KEQL-SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1572
Query: 364 NLEVLLFTIQSKLRANNQKVY-----------TPREGRLISD-----INKAWERLEKAEH 407
+++V + K+ A Q+ Y T E RLI I L+K +
Sbjct: 1573 DVKV-----EEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1627
Query: 408 ERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467
++E EL Q+ ++ A E +L EN +SQ++ L + A K
Sbjct: 1628 KQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1680
Query: 468 EAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL------RQMVA 521
E + + V A + E+ +K++ + + L D+L +
Sbjct: 1681 EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1740
Query: 522 ARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDL-GRHLAGVEDLLQLHELVEAD- 579
+ ++++ D + +E+ G L D+ G+ E+L Q ++ V+A
Sbjct: 1741 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1800
Query: 580 ---IAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYE-ALCELAAARRA 635
I+ + A ++ + G+ P + + + + + +L+ YE AL E +
Sbjct: 1801 EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL 1860
Query: 636 RLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR-DLTGALRLLNKHTALRGEMSGRL 694
L +F + E E W+++ + L + + G D+ G + L + + ++
Sbjct: 1861 THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK 1920
Query: 695 GPLKLTLEQGQQLV------AEGHPGASQASARAAELQA-------QWERLEALAEERAQ 741
G L+ G +++ ++ G SA E+Q ++ L +
Sbjct: 1921 GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN 1980
Query: 742 RLAQAASLYQFQADAN-----DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
L YQ DA+ ++A A + +S P + D + Q + +AL+ +I
Sbjct: 1981 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP-IAVDPKNLQRQLEETKALQGQI 2039
Query: 797 RSHRPTLDALREQAAAL----PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAAL 852
S + ++ L++ A L L ++Q + + YE+L ER L+ L
Sbjct: 2040 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2099
Query: 853 ALYTMLSEAGACGLWVEEKEQWLNGL--------ALPERLEDLEVVQQRFETLEPEMNTL 904
+ + ++E W+ + +P L+ + + LE ++
Sbjct: 2100 TRSLSVQDG------LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2153
Query: 905 AAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS----ALSI 960
+ I A+N+ ++ ++ P + Q ++ +F + K L +
Sbjct: 2154 QSSINAMNEKVKKFMETTDP--STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2211
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT----ERDLEAIAARVG 1016
+ + + Q ++ KT+ + G D+ + ++ ++ LE + + +
Sbjct: 2212 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2271
Query: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLD 1075
E++ + G P+ + + + ++++ T++ ++E++ + +L F +
Sbjct: 2272 EIS------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVK 2325
Query: 1076 DFQAWLGRT-------QTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128
++W+ T Q + +E+ +L + + L + + E+++ + L L
Sbjct: 2326 SLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLI 2385
Query: 1129 EEVTRDQ--------------------------ADPQCLFLRQRLEALGTGWEELGRMWE 1162
VT A+ +++ + + G+E+LG + +
Sbjct: 2386 SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK 2445
Query: 1163 SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-------HTEMPGTLQAADAAIKKLE 1215
++A+ + L+ A++ + ++ T P +A +++ +
Sbjct: 2446 D---KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2502
Query: 1216 DFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLR 1275
F + + N ++ L + +L+ E + R K + K Q+ Q + R +
Sbjct: 2503 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK-QMLTEIDSKWQELNQLTIDRQQ 2561
Query: 1276 DNREQQHFLQDCH----ELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAAN 1329
E + L +LK W+ EK M++ + L+T+ Q+ Q + E A
Sbjct: 2562 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATR 2621
Query: 1330 KDWLDKVDKEGRELTL---EKPELKALVSEKLRDLHRRWDEL--------ETTTQAKARS 1378
K +++ G+ + E P L+ +V E+L + ++WD L + QA +S
Sbjct: 2622 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2681
Query: 1379 LFDANRAELFAQSCCALESWL-ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
+ + L++ L SL H D ++N L+ Q ++ E+ +K
Sbjct: 2682 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD-------AMNQQLETAQKMKQEIQQEKK 2734
Query: 1438 EVEAIQA---QAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ-ASREQHQF 1493
+++ QA AL +E+ E+ R + + F+ + Q + LQ A HQF
Sbjct: 2735 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2794
Query: 1494 HRDVEDEILWV-TERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI--QGH--EPRIAD-- 1546
+ D W+ T++ S L ++ L+K ++ K + Q H E IA+
Sbjct: 2795 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2854
Query: 1547 -LRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAWM 1604
L + + AA +L ++ W +++ R +L+++L Y++ E W+
Sbjct: 2855 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2914
Query: 1605 GEQELHM----------MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDM 1654
+ + ++ G+ S Q E+ +H + + L + A ++ + +++
Sbjct: 2915 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2974
Query: 1655 IDHEHP---ESTRISIRQAQVDKL-YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
+ E+ + + Q K + + E +E +E R Q +E D+ +
Sbjct: 2975 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3034
Query: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
+ +++TML+ + + + +VD A LA L+ ++
Sbjct: 3035 GSQ---------AYSNKYLTMLQTQQKSLQ-----ALKHQVDLAKRLAQDLVVEASDSKG 3080
Query: 1771 T--VAEWKDSLNEAWADLLELLDTRGQVLAAAYE-LQRFLHGARQALARVQHKQQQLPD- 1826
T V +++ + + L + +D + L + + F + R+ ++ +L
Sbjct: 3081 TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSM 3140
Query: 1827 -GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEE-------- 1877
GRD AE LQ++ + I+A +++ + K A E
Sbjct: 3141 APVGRD---AETLQKQ----KETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVG 3193
Query: 1878 IGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF-RFFKAVRELMLWMDEVNLQMDAQERP 1936
I R ++A+++ +L + AR + + T + F+ ++E + + + + +E
Sbjct: 3194 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE---EHEESQ 3250
Query: 1937 RDVSSADLVIKNQQGI-----KAEIEARADRFSSCIDMGKELL--ARSHYAAEEISEKLS 1989
V I Q + K EIE + +G+ L+ A + + + L
Sbjct: 3251 GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD 3310
Query: 1990 QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAE---AWLCSQEPLV 2036
+ AR + +K ++ LQ L L GR E +W+ E LV
Sbjct: 3311 DVNARWKTLNKKVAQRAAQLQEAL--LHCGRFQDALESLLSWMVDTEELV 3358
Score = 106 bits (264), Expect = 3e-22
Identities = 329/1810 (18%), Positives = 700/1810 (38%), Gaps = 208/1810 (11%)
Query: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
++ I W+ K ERE L+ E LE+ A ++ + W+ + Q + +
Sbjct: 2872 LNTIKTNWDTFNKQVKERENKLK------ESLEK-ALKYKEQVETLWPWIDKCQNNLEEI 2924
Query: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
F L+ A E ++ K ++++ ++ + G V+ ++ A L + D + + ++ +
Sbjct: 2925 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2984
Query: 512 LWDFLRQMVAARRERLLLNLELQKVFQ--------------------DLLYLMDWMEEMK 551
D + + + +++ L + K FQ D L + +
Sbjct: 2985 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3044
Query: 552 GRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL 611
LQ+Q + L ++ + L + + D+ V+A + S L+ +E+ Q
Sbjct: 3045 TMLQTQQ--KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ- 3101
Query: 612 VSERVAKLEQSYEALCELAAARRARLEE--------------SRRLWRFLWEVGEAEAWV 657
V E+ + LE + + R + R + +A++
Sbjct: 3102 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3161
Query: 658 REQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQ 717
++ + L+AS D T + L + T+ ++ G L+ +Q +L+ +
Sbjct: 3162 KKLEALMASNDNANK-TCKMMLATEETS--PDLVGIKRDLEALSKQCNKLL-------DR 3211
Query: 718 ASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGH 777
A AR +++ +RLE E +L + + L Q + + + P
Sbjct: 3212 AQAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEESQG-----------PVGME 3256
Query: 778 DEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLE---RHY 834
E Q L +EEI + + L + +++ QG L+ +
Sbjct: 3257 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3316
Query: 835 EELQARAGERARALEAAL--------ALYTMLSEAGACGLWVEEKEQWLNGLALPERLED 886
+ L + +RA L+ AL AL ++LS W+ + E+ + P +
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLS-------WMVDTEELVANQKPPSA--E 3367
Query: 887 LEVVQ---QRFETLEPEMNTLAAQITAVNDIAEQLLK-ANPPGKDRIVNTQEQLNHRWQQ 942
+VV+ Q + L+ ++ + + + E++ A P K +I+ L+ RW+
Sbjct: 3368 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3427
Query: 943 FRRLADGKKAALTS-ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKL 1001
A+ + L ++ Q +H W+ K + + + +G + + +
Sbjct: 3428 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3487
Query: 1002 AGTERDLEAIAARVGELTREANALAAGHPAQAVA-------INARLREVQTGWEDLRATM 1054
E D+ + A++ G + ++ + ++L Q + +++
Sbjct: 3488 KALEDDI------INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKS 3541
Query: 1055 RRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVA--SEEGPATLPEAEALLAQHAALR 1111
R E L +A + F + WL ++ S + +T E L Q + LR
Sbjct: 3542 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST----EGLWKQQSELR 3597
Query: 1112 ---GEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
++ + + G E+ + + L ++ +LEA+ ++++ ++ L
Sbjct: 3598 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657
Query: 1169 AQAHGFQGFLRDARQA---------EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMS 1219
QA L + +LS + VL E K+ ++ +
Sbjct: 3658 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3717
Query: 1220 TMDANGERIHGLLEAG--------RQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFL 1271
+D+ E LLE ++V+E N ++ R +D+I ++ ++ A +
Sbjct: 3718 LLDSLNEVSSALLELVPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILR-- 3772
Query: 1272 GRLRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAA 1328
Q F Q WI E K+++ D+ ++ + + Q + F E+
Sbjct: 3773 --------SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3823
Query: 1329 NKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAEL 1387
+KD +D + K G ++ T E K + +KL + + +D T Q + RA+
Sbjct: 3824 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYD---TICQINSERYLQLERAQS 3880
Query: 1388 ----FAQSCCALESWL---ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE 1440
F ++ L WL +S+ +QL + + ++ ++ + L +A + ++
Sbjct: 3881 LVNQFWETYEELWPWLTETQSIISQLPAP--ALEYETLRQQQEEHRQLRELIAEHKPHID 3938
Query: 1441 AIQAQAKALAQEDQGAG-EVERTSRAVEEKFRALCQPMRERCRRL-QASREQHQFHRDVE 1498
+ L + G G ++ A + + + + +++R L +A + QFH D
Sbjct: 3939 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFH-DKI 3997
Query: 1499 DEILWVTERL------PMASSMEHGK------DLPSVQLLMKKNQTLQKEI-QGHEPRIA 1545
D+IL ER+ P + S E K + +V + M+K Q L + + Q E IA
Sbjct: 3998 DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4057
Query: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWM 1604
+ + A A +L ++ +W+ + +E R +L D + A++F+ D +
Sbjct: 4058 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTI 4117
Query: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQ-----LAASSQDMIDHEH 1659
+ + + E + S VK+ Q + + + + + + S+ +
Sbjct: 4118 KDTQDFIRDLEDPGIDPSV---VKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGE 4174
Query: 1660 PESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC-QLRRELDDLEQWIQ-EREVVA 1717
P+ + +++ + L + +R ++L+E ++ Q + L + W+ +A
Sbjct: 4175 PDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA 4234
Query: 1718 ASHELGQDYEHVTMLRDKFREFSRDT--STIGQERVDSANALANGLIAGGHAARATVAEW 1775
+ +G D E V ++ ++F + I ER++ L + + + TV +
Sbjct: 4235 SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE-ESDKHTVQDP 4293
Query: 1776 KDSLNEAWADLLELLDTRGQVLAAAY-ELQRFLHGARQALARVQHKQQQLPDG--TGRDL 1832
L W L E + R L A L +F H + LA + H + L + G D
Sbjct: 4294 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4353
Query: 1833 NAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
A E +H ++D+ A V+ V G+ L ++ AG++A + ++ + + W +
Sbjct: 4354 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4413
Query: 1893 QGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
+ R+Q L + + F + +L W+ + + A + + K Q
Sbjct: 4414 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS---KPLGGLPETAKEQLN 4470
Query: 1952 IKAEI----EARADRFSSCIDMGKELLARSHYAAE-EISEKLSQLQARRQETAEKWQEKM 2006
+ E+ EA+ + + S + G+++LAR +AE I + ++ L+ + + K E+
Sbjct: 4471 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4530
Query: 2007 DWLQLVLEV-LVFGRDAGMAEAWLCSQEPLVRSAEL-GCTVDEVESLIKRHEAFQKSAVA 2064
L+ L + + F WL E + A +D V I H+ F +
Sbjct: 4531 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4590
Query: 2065 WEERFCALEK 2074
E+ L+K
Sbjct: 4591 HREQIIELDK 4600
Score = 68.9 bits (167), Expect = 6e-11
Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 16/282 (5%)
Query: 535 KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASA 594
K QDLL +W++EM+ +L + G L VE L+ H+ V I ++ S
Sbjct: 635 KFVQDLL---NWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 691
Query: 595 LRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAE 654
++ P K +E++ +LE Y L + + L+ L F+
Sbjct: 692 IQMTAPLK-------LTYAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNEL 741
Query: 655 AWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG 714
W+ E++ + D T R + H L E+ + +K E +QL+ E HP
Sbjct: 742 IWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 801
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAW---LVDALRLVS 771
A A +Q QW + L + Q + + + ++F DA + + L DA++
Sbjct: 802 RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKY 861
Query: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL 813
S + + L ++ +EE+ ++ T+ L +A +
Sbjct: 862 SCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 903
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/266 (18%), Positives = 109/266 (40%), Gaps = 24/266 (9%)
Query: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPES 1662
W+ E ++ + E D S ++ ++ H+ + +A+ ++ ++ + S M P
Sbjct: 643 WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLK 699
Query: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLEQWIQEREVVAASHE 1721
+ + +++ YA L + + L H + + EL W+ E+E +++
Sbjct: 700 LTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELI----WLNEKEEEEVAYD 755
Query: 1722 LGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNE 1781
+ ++ +D E R+ +E + S +A L+ H AR T+ ++ ++
Sbjct: 756 WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 814
Query: 1782 AWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRR 1841
W+ +L+L Q + F + A++A ++ N +A+QR+
Sbjct: 815 QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR--------------NLKDAIQRK 860
Query: 1842 H-CAYEHDIQALSPQVQQVQDDGHRL 1866
+ C I L VQ+ ++ L
Sbjct: 861 YSCDRSSSIHKLEDLVQESMEEKEEL 886
Score = 45.8 bits (107), Expect = 5e-04
Identities = 52/280 (18%), Positives = 110/280 (39%), Gaps = 28/280 (10%)
Query: 296 VLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSF-NSYRTVE 354
+LD + E + K+ +LL W+++ V L+ + + L V++ L++ N +R +E
Sbjct: 622 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 678
Query: 355 KPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALR 414
+ ++ + + T KL Y E+L + E + L
Sbjct: 679 EFESSLKEAKISEIQMTAPLKL------TYA--------------EKLHRLESQYAKLLN 718
Query: 415 TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDI 474
T ++ L+ L F +A WL+E + ++ + H + ++
Sbjct: 719 TSRNQERHLDTLH-NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 777
Query: 475 VAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534
+++V +A +L E + I A + + W ++ Q+ + + N
Sbjct: 778 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 837
Query: 535 KVFQDLLYLMDWMEEMKGRLQ---SQDLGRHLAGVEDLLQ 571
+ F D D++ +K +Q S D + +EDL+Q
Sbjct: 838 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ 877
Score = 45.8 bits (107), Expect = 5e-04
Identities = 205/1138 (18%), Positives = 417/1138 (36%), Gaps = 193/1138 (16%)
Query: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064
+++LE + +G +T + + A + R E+ +++ + +
Sbjct: 1142 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLR-SELNVVLQNMNQVYSMSSTYIDKL 1200
Query: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSR 1123
+ + L++ +A + +T + EE A E L++ R EV+ + +
Sbjct: 1201 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF-- 1258
Query: 1124 LRALGEEVTRDQADPQCLFLRQRLEALGTGW-----EELGRMWESRQGRLAQAHGFQGFL 1178
AL +E+ + +A +F + L W ++L W++ ++
Sbjct: 1259 -HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR------- 1310
Query: 1179 RDARQAEGVLSSQEYVL-SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQ 1237
R EG+ S +Y ++ + +Q + +K+++ N + + L +
Sbjct: 1311 --LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQE---NQPENSKTLATQLNQQKM 1365
Query: 1238 LVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ---HFLQDCHELKLWI 1294
LVSE + K+ E Q A+Q+ ++D Q + D +
Sbjct: 1366 LVSEIEMKQSKMDEC-----------QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1414
Query: 1295 DEKMLTAQDVSYDEARNLHTKWQKHQAFMAE-LAANKDWLDKVDKEGRELTLEKPELKAL 1353
+M ++ D+ E +L T++ M + + D L ++++E + L EK E
Sbjct: 1415 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHV-- 1472
Query: 1354 VSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK 1413
EK ++L + + T L DA +A S + + S + + +
Sbjct: 1473 --EKAKELQKWVSNISKT-------LKDAEKAGKPPFS----KQKISSEEISTKKEQLSE 1519
Query: 1414 DLTSVNILLKKQ--QMLEWEMAVREKEVEAIQAQAKAL-------AQEDQGAGEVERTSR 1464
L ++ + L K +M + E EK+V+ +Q L QE Q +G+V+ +
Sbjct: 1520 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK 1579
Query: 1465 AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQ 1524
V E+ + + ++ C L + + H++ + G ++
Sbjct: 1580 IVAERQQEYKEKLQGICDLLTQTENRLIGHQE----------------AFMIGDGTVELK 1623
Query: 1525 LLMKKNQTLQKEIQGHEPRIAD--------LRERQRALG---AAAAGPELAELQEMWKRL 1573
K + LQK++QG +A+ L+E L A +L E + ++L
Sbjct: 1624 KYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1683
Query: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL------SAQAEV 1627
+ E K L+ + ++ E A + + E E D L S +A
Sbjct: 1684 NLKAEQSKKELDKVVTTA--IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1741
Query: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPEST---RISIRQAQVDKLYAGLKE--- 1681
K QV+EQ + + + A +D ++ E+ ++ Q +++ Y +K
Sbjct: 1742 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1801
Query: 1682 --------------------------LAGERRERLQEHLRLCQ----------------- 1698
L+ E +E+LQ++++ +
Sbjct: 1802 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1861
Query: 1699 --LRRELD-------DLEQWIQEREVVAASHELGQDYEHVTMLR-DKFREFSRDT----- 1743
L+ EL+ + E W+Q+ E + E G D + M + + + FS D
Sbjct: 1862 HSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG 1921
Query: 1744 ----STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLA- 1798
TI RV A + G AT E + L+ A D L ++ VL
Sbjct: 1922 DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA-TDRFRSLYSKCNVLGN 1980
Query: 1799 ----AAYELQRFLHGARQALARVQ--------HKQQQL---PDGTGRDLNAAEALQRRHC 1843
+ Q + + LA +Q H + + P R L +ALQ +
Sbjct: 1981 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2040
Query: 1844 AYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQ-L 1902
+ + ++ L + + D L A +I + + + + L S R + L
Sbjct: 2041 SQQVAVEKLKKTAEVLLDARGSLLPA-----KNDIQKTLDDIVGRYEDLSKSVNERNEKL 2095
Query: 1903 LLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ-ERPRDVSSADLVIKNQQGIKAEIEARAD 1961
+ T + E++ WM V + Q + P + ++ +I ++ +I R
Sbjct: 2096 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2155
Query: 1962 RFSSCIDMGKELLARSH-YAAEEISEKLSQLQARRQETAEKWQE---KMDWLQLVLEV 2015
++ + K+ + + A + K+ L AR E + K +E KM+ L+ +E+
Sbjct: 2156 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL 2213
Score = 43.1 bits (100), Expect = 0.003
Identities = 62/299 (20%), Positives = 118/299 (39%), Gaps = 36/299 (12%)
Query: 1378 SLFDANRAE-----LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML---- 1428
SL D N E F Q L +W++ +Q QL ++G DL SV L+ + +
Sbjct: 621 SLLDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 677
Query: 1429 -EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQAS 1487
E+E +++E ++ IQ A E+ R +E ++ L R + R L
Sbjct: 678 EEFESSLKEAKISEIQMTAPLKLT------YAEKLHR-LESQYAKLLNTSRNQERHLDT- 729
Query: 1488 REQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL 1547
H F +E++W+ E+ + + + ++ + L +E+ E I +
Sbjct: 730 --LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSV 787
Query: 1548 RERQRALGAAAAGPEL------AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
+E L L A +Q W + + + +++ +F+ DA EA
Sbjct: 788 QEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 847
Query: 1602 AWMGEQELHMMGQEKAKDELSAQAE-----VKKHQVLEQALADYAQTIHQLAASSQDMI 1655
++ + L Q K + S+ V++ ++ L Y TI L ++ +I
Sbjct: 848 DYL--RNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 904
Score = 40.8 bits (94), Expect = 0.016
Identities = 37/205 (18%), Positives = 84/205 (40%), Gaps = 16/205 (7%)
Query: 1497 VEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGA 1556
V+D + WV E E G DLPSV+ ++ ++ + + I+ E + + + + +
Sbjct: 637 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM-- 694
Query: 1557 AAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRD--------AAEAEAWMGEQE 1608
A L+ + H LE + +L + R Q+ + D A W+ E+E
Sbjct: 695 ------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKE 748
Query: 1609 LHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIR 1668
+ + ++ + + H L + L + I + ++ ++ HP I
Sbjct: 749 EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 808
Query: 1669 QAQVDKLYAGLKELAGERRERLQEH 1693
+A + ++ + +L + ++E+
Sbjct: 809 RAAMQTQWSWILQLCQCVEQHIKEN 833
Score = 40.4 bits (93), Expect = 0.021
Identities = 44/225 (19%), Positives = 86/225 (38%), Gaps = 5/225 (2%)
Query: 758 DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTL 817
D+ W+ + + E G D S ++ H+ + I +L + + L
Sbjct: 639 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPL 698
Query: 818 SRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNG 877
T ++ LE Y +L + + R L+ L+ +S A +W+ EKE+
Sbjct: 699 KLT--YAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVA 753
Query: 878 LALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLN 937
ER ++ + L E++ I +V +IAEQLL N P + I + +
Sbjct: 754 YDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQ 813
Query: 938 HRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIE 982
+W +L + + + + + E ++R I+
Sbjct: 814 TQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 858
Score = 33.5 bits (75), Expect = 2.6
Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 8/100 (8%)
Query: 1914 KAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGK-- 1971
K V++L+ W+DE+ +Q+D E D+ S + ++N + + IE F S + K
Sbjct: 635 KFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE----EFESSLKEAKIS 690
Query: 1972 --ELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++ A E +L A+ T+ + +D L
Sbjct: 691 EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL 730
Score = 32.0 bits (71), Expect = 7.5
Identities = 105/572 (18%), Positives = 223/572 (38%), Gaps = 70/572 (12%)
Query: 1565 ELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE-AEAWMGE--------QELHMMGQE 1615
+L E W+ + +++ R + LE ++ ++YRD + W+ + QE +
Sbjct: 1295 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 1354
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQT-IHQLAASSQD----------MIDHEHPESTR 1664
+L+ Q + ++Q+ D Q Q +A+ +D M+D + +
Sbjct: 1355 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1414
Query: 1665 ISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQ 1724
Q+ D + +L R L ++ D L++ +E + + +
Sbjct: 1415 RRRMQSSADLIIQEFMDL--RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK--- 1469
Query: 1725 DYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWA 1784
EHV +K +E + S I + D+ A + + ++ K+ L+EA
Sbjct: 1470 --EHV----EKAKELQKWVSNISKTLKDAEKA-GKPPFSKQKISSEEISTKKEQLSEALQ 1522
Query: 1785 DLLELLDTRGQVLA--AAYELQRFLHGARQA--LARVQHKQQQLPDGTGRDLNAAEAL-Q 1839
+ L G + EL++ + +++ L + +Q T D+ E +
Sbjct: 1523 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1582
Query: 1840 RRHCAYEHDIQALSPQVQQVQDDGHRLQKAY-AGDKAEEIGRHMQAVAEAWAQLQGSSAA 1898
R Y+ +Q + + Q ++ Q+A+ GD E+ ++ E +QGS+ A
Sbjct: 1583 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1642
Query: 1899 RRQLLLDT-------------TDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLV 1945
+++ +T DK + + E + +++NL+ + ++ D +
Sbjct: 1643 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1702
Query: 1946 IKNQQGIKA--EIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQ 2003
+ + + A ++E + + +D + S A + + + Q QE K
Sbjct: 1703 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1762
Query: 2004 --EKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS 2061
E+ + +LE V G+ G + L Q V++ + E +I +H+A
Sbjct: 1763 IGEEDEVNGNLLETDVDGQ-VGTTQENLNQQYQKVKA--------QHEKIISQHQAV--- 1810
Query: 2062 AVAWEERFCALEK---LTALEEREKERKRKRE 2090
+A + LEK + EE+EK +K +E
Sbjct: 1811 IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1842
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 315 bits (806), Expect = 4e-85
Identities = 182/406 (44%), Positives = 250/406 (61%), Gaps = 15/406 (3%)
Query: 51 LADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGR 110
+ADER+ VQKKTFTKW+N HL +V V DLY DLRDG NL+ LLEVLSG+ LP+ KGR
Sbjct: 69 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 127
Query: 111 MRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETE 170
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V E
Sbjct: 128 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 187
Query: 171 DNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKK 230
E SAK+ LLLW Q T GY + NFTT WRDG FNAI+HK+RPDL+D ++
Sbjct: 188 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 245
Query: 231 CNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEG 290
+ NL++AF +AEK +G+ +LLDPEDV+V PDEKS+ITYV++ Y F K+ G
Sbjct: 246 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 301
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSY 350
+ IG A + E +Y+++ + L+QWI + T+++R N+ ++ + +
Sbjct: 302 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 356
Query: 351 RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERE 410
+ E PPK TEK ++ L ++ + K+ +G +DI K W +L A ERE
Sbjct: 357 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 413
Query: 411 LALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLE 456
ALR E+ R E L+Q+A R R + + E L + D+ LE
Sbjct: 414 KALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE 459
Score = 159 bits (403), Expect = 2e-38
Identities = 343/1769 (19%), Positives = 687/1769 (38%), Gaps = 166/1769 (9%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTI-VTLNDRQLANSLSGVQNQLQSFNS 349
K++ + EA +++ LL W+ T + N + + V+ Q+Q
Sbjct: 3332 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL 3391
Query: 350 YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHER 409
+ + K T +EV+ + +K+ T E +D K ++L +
Sbjct: 3392 LQRLLDDRKST----VEVI--------KREGEKIATTAEP---ADKVKILKQLSLLDSRW 3436
Query: 410 ELALRTELIRQEKLEQL---AARFDRKAAMRETWLSE-NQRLVSQDNFGLELAAVEAAVR 465
E L R +LE + A +F WL+ +RLV+ + G + + +E +
Sbjct: 3437 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3496
Query: 466 KHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDF-LRQMVAARR 524
+H+A+E DI+ ++ + ++ L + K + + + +++W +++ +R
Sbjct: 3497 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3556
Query: 525 ERLLLNLELQKVF-QDLLYLMDWMEEMKGRLQSQDLGRHLA-GVEDLLQLHELVEADIAV 582
E L L K+F +D + LM+W+ E+ +L + + G+ +++ DI +
Sbjct: 3557 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3616
Query: 583 QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642
+ + V + L K+ + ++ +++ ++ Y+ + +L+ LE++ +
Sbjct: 3617 RKQNVDQALLNGLELL---KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673
Query: 643 LWRFLWEVGEAEA-WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTL 701
L R L E W+ + + L S +T ++L A + +M R LK
Sbjct: 3674 LARRLHSTHEELCTWLDKVEVELLSYET--------QVLKGEEASQAQM--RPKELKKEA 3723
Query: 702 EQGQQLVAEGHPGASQASARAAELQAQW---ERLEALAEERAQRLA-------------Q 745
+ + L+ ++ S+ EL W E LE + E +R
Sbjct: 3724 KNNKALL----DSLNEVSSALLEL-VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778
Query: 746 AASLYQFQAD-ANDME-AWLVDA-LRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPT 802
AA L Q D A D E +W+ + +L+S ++ ++ T A + + EI H+
Sbjct: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838
Query: 803 LDALREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSE 860
+D L + + S + ++ ++ + ++Y+ + ER LE A +L E
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898
Query: 861 A-GACGLWVEEKEQWLNGLALPE-RLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918
W+ E + ++ L P E L Q+ L + I +N QL
Sbjct: 3899 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3958
Query: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN-YHLECTETQAWMREK 977
L+ +P I + + Q + + AL A+S +H + + +
Sbjct: 3959 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LESL 4015
Query: 978 TKVIESTQGLGNDLAGVLALQRKLAGTER---DLEAIAARVGELTREANALAA-----GH 1029
+++E + + A V ++ +++ + D+E + L + + A
Sbjct: 4016 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4075
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQD-FLRSLDDFQAWLGRTQTAV 1088
A A+ +L ++ WE++ + RE L + L + F + TQ +
Sbjct: 4076 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4135
Query: 1089 ASEEGPATLPEAEALLAQHA-ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147
E P P + A +R E++ Q E + LG E+ +P +++ +
Sbjct: 4136 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4195
Query: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA--EGVLSSQEYVLSHTEMPGTLQ 1205
+ L + W+ L + W+ R +L +A +D QA + V + + S + + L+
Sbjct: 4196 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4255
Query: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK---------IREKADSI 1256
I++L+ F S + L L+ + +DK ++ DS+
Sbjct: 4256 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4315
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWI--DEKMLTAQDVSYDEARNLHT 1314
E R Q + G L + QH L EL W+ E +L+ Q + + +
Sbjct: 4316 EERIINRQHKLE---GALLALGQFQHALD---ELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369
Query: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP-ELKALVSEKLRDLHRRWDE-LETTT 1372
+ KH ++ A++ ++ V+K G +L E + + KL L++RW LE T
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429
Query: 1373 QAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEM 1432
Q K + +A+ F L+ WL + L + K L + K+Q + E+
Sbjct: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVHMEV 4486
Query: 1433 AVREKEVEAIQAQAKALAQEDQ---------GAGEVERTSRAVEEKFRALCQPMRERCRR 1483
EA + K+L Q+ Q +++ ++EK+ ++ + ER +
Sbjct: 4487 CA---AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4543
Query: 1484 L-QASREQHQFHRDVEDEILWVTE-RLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHE 1541
L +A +FH ++D I W+T+ + + L +V + +++ E+ H
Sbjct: 4544 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4603
Query: 1542 PRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDA-LRAQQF 1593
+I +L + L + + L +Q W+++ L RG+ L+DA RA+QF
Sbjct: 4604 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4663
Query: 1594 YRDAAEAEAWMGEQELHMMGQ-EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQ 1652
+ ++ W+ E E + + E A D + ++ +H+ +++L + +
Sbjct: 4664 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4723
Query: 1653 DMIDHEHPESTRISIRQAQVDKLYAGLKE----LAG---ERRERLQEHLRLC-QLRRELD 1704
+ E T ++ ++D + + L++ + G ER+ +L+E L Q L
Sbjct: 4724 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQ 4778
Query: 1705 DLEQWIQERE-VVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL---ANG 1760
L W+ E +A + D + V L D + F ++ +R S AL A
Sbjct: 4779 ALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELG----KRTSSVQALKRSARE 4834
Query: 1761 LIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHK 1820
LI G + V L+ W + L ++ L AA H AL +
Sbjct: 4835 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE 4894
Query: 1821 QQQ-------LPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
+Q LPD D +A L +H + ++ ++ + G + D
Sbjct: 4895 AEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4950
Query: 1874 KAEEIGRHMQAVAE------AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927
I + + AWA+ A L K +A+ + W +
Sbjct: 4951 SITTIKHWITIIRARFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTL 5008
Query: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEI 1956
D + P+++ +I Q E+
Sbjct: 5009 TDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Score = 129 bits (325), Expect = 3e-29
Identities = 339/1876 (18%), Positives = 719/1876 (38%), Gaps = 160/1876 (8%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLN---DRQLANSLSGVQNQL--Q 345
K+ K+LD A E VE E +++ + L + + + G++ + Q
Sbjct: 3214 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3273
Query: 346 SFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKA 405
N ++ +K +G + + + Q +++ + T + D+N W+ L K
Sbjct: 3274 QLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK 3333
Query: 406 EHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV-SQDNFGLELAAVEAAV 464
+R L+ L+ RF +W+ + + LV +Q E V+A +
Sbjct: 3334 VAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQI 3386
Query: 465 RKHEAIETDIVAYSGRVQAVDAVAAELA--AERYHDIKRIAARQHNVARLWDFLRQMVAA 522
++ + ++ + V+ + ++A AE +K I + + W+ L
Sbjct: 3387 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSRWEALLNKAET 3445
Query: 523 RRERLL-LNLELQKVFQDLLYLMDWMEEMKGRL-QSQDLGRHLAGVEDLLQLHELVEADI 580
R +L +++ Q+ + L L +W+ ++ RL + +G + +E+ + H+ +E DI
Sbjct: 3446 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3505
Query: 581 AVQAERV-RAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEE 639
+ + +AVS +E D +V ++ + Y + E + +R L++
Sbjct: 3506 INHNKHLHQAVSIGQSLKVLSSRE----DKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3561
Query: 640 SRRLWRFLWE-VGEAEAWVREQQHLLASADTGRDLT-------GALRLLNKHTALRGE-- 689
+ + E E W+ E L+ T LR+L + LR +
Sbjct: 3562 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3621
Query: 690 ---MSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+ L LK T ++ + + ++A+++ + L+ + A+ L QA
Sbjct: 3622 DQALLNGLELLKQTTGDEVLIIQD----------KLEAIKARYKDITKLSTDVAKTLEQA 3671
Query: 747 ASL-YQFQADANDMEAWL--VDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803
L + + ++ WL V+ L ++ E ++QA R + L++E ++++ L
Sbjct: 3672 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNNKALL 3730
Query: 804 DALREQAAALPPTLS-RTPE-VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861
D+L E ++AL + R E ++ V Y + ++ ++AA+ +A
Sbjct: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790
Query: 862 GACGL-WVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK 920
L W+ E E+ L L D+ + Q + T +I DI + L+K
Sbjct: 3791 ADAELSWITETEKKLMSLG------DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3844
Query: 921 A--------NPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC-TETQ 971
+ + K + +++ + ++ + L A S+ N E E
Sbjct: 3845 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3904
Query: 972 AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
W+ E +I + + Q + + + ++ + L P
Sbjct: 3905 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEA-RRLQDFLRSLDDFQAWLGRTQTAVAS 1090
+ +I + T + ++ +++R +L EA + F +D L R +
Sbjct: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL-- 4022
Query: 1091 EEGPATLPEAEAL---LAQHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFL 1143
+ P+ E E + ++++ + ++E+ Q Y L+ GEE+ D +
Sbjct: 4023 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
Query: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGF-QGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
+ +L+ + WE + + E R+ +L + F D + + + E PG
Sbjct: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142
Query: 1203 -----TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSE-GNIHADKIREKADSI 1256
Q +AA E +D E + ++ G +L++ G +++ D +
Sbjct: 4143 IDPSVVKQQQEAA----ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4198
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKL-WID---EKMLTAQDVSYDEARNL 1312
A + + +L + + QD + W+D K+ + + D +
Sbjct: 4199 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD-LETV 4257
Query: 1313 HTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK---PELKALVSEKLRDLHRRWDELE 1369
+ ++ + F +E + +++++ + EL L+K K V + L +L WD LE
Sbjct: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4316
Query: 1370 TTTQAKARSLFDANRA-ELFAQSCCALESWLESLQAQL-HSDDYGKDLTSVNILLKKQQM 1427
+ L A A F + L +WL + L G D ++ I L K +
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4376
Query: 1428 LEWEMAVREKEVEAIQAQAKALAQEDQG--AGEVERTSRAVEEKFRALCQPMRERCRRLQ 1485
L+ ++ + VEA+ L + G A ++ + ++++ + + +R ++L
Sbjct: 4377 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4436
Query: 1486 -ASREQHQFHRDVEDEILWVTE-------RLPMASSMEHGKDLPSVQL-----LMKKNQT 1532
A R+ FH ++ED W+T+ P+ E K+ +V + K +T
Sbjct: 4437 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4496
Query: 1533 LQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQ 1591
+ +Q + +A R ++ L+E W+ + +L R +LE+AL A
Sbjct: 4497 YKSLMQKGQQMLA----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
Query: 1592 QFYRDAAEAEAWM--GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAA 1649
+F+ + W+ EQ L++ + + + ++ +H+V + + + I +L
Sbjct: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILD-TVLFQIDEHKVFANEVNSHREQIIELDK 4611
Query: 1650 SSQDM-IDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLE 1707
+ + + + I V + + + ER L + R Q L
Sbjct: 4612 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4671
Query: 1708 QWIQEREVVAASH-ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGH 1766
+W++E E S E+ D + + + +EF + D+ N L
Sbjct: 4672 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA-KHSVYDTTNRTGRSL----- 4725
Query: 1767 AARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPD 1826
+ ++A+ L++ ++L + DT + + E Q L A + Q L D
Sbjct: 4726 KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDALQALID 4782
Query: 1827 GTGR-------------DLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
R D++ L H A++ ++ + VQ ++ L + + D
Sbjct: 4783 WLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRD 4841
Query: 1874 KAEEIGRHMQAVAEAW---AQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQM 1930
+ + MQ ++ W L S R + L ++F V L+ W+ E +
Sbjct: 4842 DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFH--SVVHALLEWLAEAEQTL 4899
Query: 1931 DAQ-ERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSH-YAAEEISEKL 1988
P D + +I + ++E + + MG +LA H + I +
Sbjct: 4900 RFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWI 4959
Query: 1989 SQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMA-EAWLCSQEPLVRSAE---LGCT 2044
+ ++AR +E ++ L L L+ ++ A AWL E + + +
Sbjct: 4960 TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE 5019
Query: 2045 VDEVESLIKRHEAFQK 2060
++EV++LI H+ F +
Sbjct: 5020 IEEVKALIAEHQTFME 5035
Score = 118 bits (296), Expect = 6e-26
Identities = 206/1008 (20%), Positives = 403/1008 (39%), Gaps = 91/1008 (9%)
Query: 399 WERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-DNFGLEL 457
WE + ERE L + +LA +F + + Q + ++ G++
Sbjct: 4093 WENIHTLVEEREAKLLDVM-------ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4145
Query: 458 AAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQ-HNVARLWDFL 516
+ V+ E I +I + V + +EL A K I + + WD L
Sbjct: 4146 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4205
Query: 517 RQMVAARRERLLLNLELQKVFQD-LLYLMDWMEEMKGRLQSQD-LGRHLAGVEDLLQLHE 574
+ R ++L ++ +QD L + DW++ G+L S +G L V+ ++ +
Sbjct: 4206 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4265
Query: 575 LVEADI---AVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
+++ ++ ER+ + L+ K D V + + +L+ +++L E
Sbjct: 4266 QFKSEAYQQQIEMERLNHQAELLLK-----KVTEESDKHTVQDPLMELKLIWDSLEERII 4320
Query: 632 ARRARLEESR-RLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTALRGE 689
R+ +LE + L +F + E AW+ + LL+ G D L KH L+ +
Sbjct: 4321 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4380
Query: 690 MSGRLGPLKLTLEQGQQLVAEGHPG--ASQASARAAELQAQWERLEALAEERAQRLAQAA 747
+ ++ + G L+ E G AS + L +W+ + E+R Q+L A
Sbjct: 4381 VLAHQSTVEAVNKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4439
Query: 748 SLYQ-FQADANDMEAWLVDALR-LVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDA 805
+ F + D++ WL D R L++S LG + + H + + T +
Sbjct: 4440 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4499
Query: 806 LREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGA 863
L ++ + ++ E + + L+ +E ++ + ER LE AL L +
Sbjct: 4500 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQ 4559
Query: 864 CGL-WVEEKEQWLNGLALPERLEDLEVVQ-QRFETLEPEMNTLAAQITAVNDIAEQLLKA 921
+ W+ + EQ LN + P + D + Q + E+N+ QI ++ L K
Sbjct: 4560 DFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL-KY 4618
Query: 922 NPPGKDRIV--NTQEQLNHRWQQF-RRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978
+D ++ N + RW++ +RL + ++ + + +H ++ W+ E
Sbjct: 4619 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4678
Query: 979 KVIESTQGLGND-------LAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
K ++S + ND LA Q+ L G + + R G +E +LA +
Sbjct: 4679 KSLDSELEIANDPDKIKTQLAQHKEFQKSL-GAKHSVYDTTNRTGRSLKEKTSLADDN-- 4735
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEAR----RLQDFLRSLDDFQAWLGRTQTA 1087
+ ++ L E++ W+ + R+ L EA + D L++L D WL R +
Sbjct: 4736 --LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID---WLYRVEPQ 4790
Query: 1088 VASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQR 1146
+A ++ + L+ H A + E+ + S L+ E+ D +++ +
Sbjct: 4791 LAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WVKVQ 4849
Query: 1147 LEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL--------SSQEYVLSHT 1198
++ L T WE + + S+Q RL A LR A + V+ +++ + H
Sbjct: 4850 MQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEAEQTLRFHG 4903
Query: 1199 EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKI--------- 1249
+P A I + ++FM ++ ++ G +++ H D I
Sbjct: 4904 VLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI--CHPDSITTIKHWITI 4961
Query: 1250 -REKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWID--EKMLTAQD--V 1304
R + + + K++Q Q+ L +Q L+ L W+ E LT +D V
Sbjct: 4962 IRARFEEVLAWAKQHQ---QRLASALAGLIAKQELLE---ALLAWLQWAETTLTDKDKEV 5015
Query: 1305 SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E + +HQ FM E+ + +DKV K + + L++
Sbjct: 5016 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5063
Score = 110 bits (275), Expect = 2e-23
Identities = 361/1905 (18%), Positives = 719/1905 (37%), Gaps = 278/1905 (14%)
Query: 362 KGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQE 421
K EVLL S L A N T + DI +E L K+ +ER L+ L R
Sbjct: 2061 KKTAEVLLDARGSLLPAKNDIQKT------LDDIVGRYEDLSKSVNERNEKLQITLTRSL 2114
Query: 422 KLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRV 481
++ D M + + L Q L A++ + K+ +E DI +
Sbjct: 2115 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2168
Query: 482 QAVDAVAAEL--------AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLEL 533
A++ + A+ +K ++AR + + A+ E L +EL
Sbjct: 2169 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK----HKETLAKMEELKTKVEL 2224
Query: 534 QKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSAS 593
F++L + E K +Q L +D+ +L + ++ + E + +
Sbjct: 2225 ---FENLSEKLQTFLETK----TQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVL 2277
Query: 594 ALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESR-RLWRFLWEVGE 652
P D LV E+ L + ++ + + ++ + + +L F V
Sbjct: 2278 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
Query: 653 AEAWVREQ-------QHLLASADTGRDLTGALRLLNKHTALRGEM--------------S 691
++W++E Q + D G+ L +L K + E+ S
Sbjct: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
Query: 692 GRLGPLKLTL---EQGQQLVAEG----------HPGASQASARAAELQAQWERLEALAEE 738
P K G L EG + G + ++ +E L L ++
Sbjct: 2398 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2457
Query: 739 RAQRL-AQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL---ARQHRALEE 794
+ L + + L + Q +++ M WL + + + T+A+ Q+++ E
Sbjct: 2458 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA 2517
Query: 795 EIRSHRPTLDALREQAAALPPTLSRTPEV---QGRVPTLERHYEELQARAGERARALEAA 851
E++ + + L+++ L TPE + + ++ ++EL +R + LE +
Sbjct: 2518 ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES 2577
Query: 852 LALYTMLSEAGA-CGLWVEEKEQWLNGLA--------LPERLEDLEVVQQRFETLEPEMN 902
T A W+ EKE ++ L L + + ++++ Q F T +P+
Sbjct: 2578 SNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE 2637
Query: 903 TLAAQITAVNDIAEQLLKANPPGKDRIVN--TQEQLNHRWQQFRRLADGKKAALTSALS- 959
L A + + PG+D + +EQL Q++ +LT LS
Sbjct: 2638 QLTAAGQGI---------LSRPGEDPSLRGIVKEQLAAVTQKWD--------SLTGQLSD 2680
Query: 960 ----IQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARV 1015
I ++ T+ Q+ +R + + L N L+ LA+ + LE
Sbjct: 2681 RCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK 2737
Query: 1016 GELTREANALAAGHPAQAVA--INARLREVQTGWEDLRATMRRREESL------------ 1061
E+ +E + AQA+ ++A ++E E L+A + R+ E +
Sbjct: 2738 QEIQQEKKQIKV---AQALCEDLSALVKE-----EYLKAELSRQLEGILKSFKDVEQKAE 2789
Query: 1062 GEARRLQD-------FLRSLDDFQAWLGRTQTAVASEEGP--ATLPEAEALLAQHAALRG 1112
+ LQ F + DFQAWL T+ ++ P A L E+L+ H
Sbjct: 2790 NHVQHLQSACASSHQFQQMSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2848
Query: 1113 EVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAH 1172
+ Y + A GE + + L+ +L + T W+ + + R+ +L ++
Sbjct: 2849 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES- 2907
Query: 1173 GFQGFLRDARQAEGV----------LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMD 1222
+ L+ Q E + L ++ L E ++ + K+++ ++
Sbjct: 2908 -LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 2966
Query: 1223 ANGERIHGLL---EAGRQLVSEGNIHADKIREKADSI-ERRHKKN---QDAAQQFLGRLR 1275
+ LL E +++V++ N + +K D + E+ H K ++ Q+F
Sbjct: 2967 LLNNTANSLLSVCEIDKEVVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE 3023
Query: 1276 DNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQ-----KHQAFMAELAANK 1330
++E + LQ C + +L I + L +Q S L T+ + KHQ +A+ A
Sbjct: 3024 VSKESKRQLQ-CAKEQLDIHDS-LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3081
Query: 1331 DWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDE----LETTTQA------KARSLF 1380
++ D +G L + E ++++ L ++ DE LET Q R +F
Sbjct: 3082 LVVEASDSKGTSDVLLQVE---TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMF 3138
Query: 1381 D---------------ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQ 1425
AE + ++++L+ L+A + S+D + + ++
Sbjct: 3139 SQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 3198
Query: 1426 QMLEWEMAVREKEVEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRL 1484
++ ++++EA+ Q L Q E VE T + +EE + L +E L
Sbjct: 3199 SP---DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL----KEFSILL 3251
Query: 1485 QASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRI 1544
Q + E + V E + ++L M + ++ L K Q + QG
Sbjct: 3252 QKAEEHEESQGPVGMETETINQQLNMFKVFQK----EEIEPLQGKQQDVNWLGQGL---- 3303
Query: 1545 ADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAW 1603
++ ++ +L ++ WK L ++ R +L++AL ++DA E+ +W
Sbjct: 3304 --IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3361
Query: 1604 MGEQELHMMGQEKAKDELS-AQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-E 1661
M + E + Q+ E +A++++ ++L++ L D T+ + + + P +
Sbjct: 3362 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC--QLRRELDDLEQWIQ--EREVVA 1717
+I + + +D + L A E R R E + + Q L+ L +W+ E+ +V
Sbjct: 3422 KVKILKQLSLLDSRWEALLNKA-ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLV- 3479
Query: 1718 ASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKD 1777
+ E + K E + + ++ L + G + E KD
Sbjct: 3480 -------NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3532
Query: 1778 ------SLNEAW-ADLLELLDTRGQVLAAA-----------YELQRFLHGARQALARVQH 1819
++ W ++ E +R ++L A EL +L+ L+++
Sbjct: 3533 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS- 3591
Query: 1820 KQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879
Q +G + + LQ DI V Q +G L K GD+ I
Sbjct: 3592 VQDYSTEGLWKQQSELRVLQ-------EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3644
Query: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAV-RELMLWMDEVNLQMDAQE---- 1934
++A+ + + S + L R + EL W+D+V +++ + E
Sbjct: 3645 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVL 3704
Query: 1935 RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQAR 1994
+ + S A + K +K E + S ++ LL + A E EK+
Sbjct: 3705 KGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE 3761
Query: 1995 R----QETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLC-SQEPLVRSAELGCTVDEVE 2049
R +T + E++D +L F + A +W+ +++ L+ ++ D+
Sbjct: 3762 RYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3819
Query: 2050 SLIKRHEAFQKSAVAWEERFCALEK-----LTALEEREKERKRKR 2089
+ ++ + F + ++ L K +TA E EK+ +K+
Sbjct: 3820 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3864
Score = 108 bits (269), Expect = 8e-23
Identities = 343/1970 (17%), Positives = 756/1970 (38%), Gaps = 251/1970 (12%)
Query: 252 KLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGK--VLDHAMEAERLVEK 309
K L+ E+ ++++ ++K + + S + + ++ GK + +E + K
Sbjct: 1466 KRLEEEEKSLEE-EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1524
Query: 310 YESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFN-SYR-----TVEKPPKFTEKG 363
E L SE LQ I+ + D+ + ++ Q+++ SY ++++ + G
Sbjct: 1525 KEQL-SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1583
Query: 364 NLEVLLFTIQSKLRANNQKVY-----------TPREGRLISD-----INKAWERLEKAEH 407
+++V + K+ A Q+ Y T E RLI I L+K +
Sbjct: 1584 DVKV-----EEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1638
Query: 408 ERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467
++E EL Q+ ++ A E +L EN +SQ++ L + A K
Sbjct: 1639 KQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1691
Query: 468 EAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL------RQMVA 521
E + + V A + E+ +K++ + + L D+L +
Sbjct: 1692 EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1751
Query: 522 ARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDL-GRHLAGVEDLLQLHELVEAD- 579
+ ++++ D + +E+ G L D+ G+ E+L Q ++ V+A
Sbjct: 1752 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1811
Query: 580 ---IAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYE-ALCELAAARRA 635
I+ + A ++ + G+ P + + + + + +L+ YE AL E +
Sbjct: 1812 EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL 1871
Query: 636 RLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR-DLTGALRLLNKHTALRGEMSGRL 694
L +F + E E W+++ + L + + G D+ G + L + + ++
Sbjct: 1872 THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK 1931
Query: 695 GPLKLTLEQGQQLV------AEGHPGASQASARAAELQA-------QWERLEALAEERAQ 741
G L+ G +++ ++ G SA E+Q ++ L +
Sbjct: 1932 GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN 1991
Query: 742 RLAQAASLYQFQADAN-----DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
L YQ DA+ ++A A + +S P + D + Q + +AL+ +I
Sbjct: 1992 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP-IAVDPKNLQRQLEETKALQGQI 2050
Query: 797 RSHRPTLDALREQAAAL----PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAAL 852
S + ++ L++ A L L ++Q + + YE+L ER L+ L
Sbjct: 2051 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2110
Query: 853 ALYTMLSEAGACGLWVEEKEQWLNGL--------ALPERLEDLEVVQQRFETLEPEMNTL 904
+ + ++E W+ + +P L+ + + LE ++
Sbjct: 2111 TRSLSVQDG------LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2164
Query: 905 AAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS----ALSI 960
+ I A+N+ ++ ++ P + Q ++ +F + K L +
Sbjct: 2165 QSSINAMNEKVKKFMETTDP--STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2222
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT----ERDLEAIAARVG 1016
+ + + Q ++ KT+ + G D+ + ++ ++ LE + + +
Sbjct: 2223 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2282
Query: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLD 1075
E++ + G P+ + + + ++++ T++ ++E++ + +L F +
Sbjct: 2283 EIS------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVK 2336
Query: 1076 DFQAWLGRT-------QTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128
++W+ T Q + +E+ +L + + L + + E+++ + L L
Sbjct: 2337 SLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLI 2396
Query: 1129 EEVTRDQ--------------------------ADPQCLFLRQRLEALGTGWEELGRMWE 1162
VT A+ +++ + + G+E+LG + +
Sbjct: 2397 SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK 2456
Query: 1163 SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-------HTEMPGTLQAADAAIKKLE 1215
++A+ + L+ A++ + ++ T P +A +++ +
Sbjct: 2457 D---KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2513
Query: 1216 DFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLR 1275
F + + N ++ L + +L+ E + R K + K Q+ Q + R +
Sbjct: 2514 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK-QMLTEIDSKWQELNQLTIDRQQ 2572
Query: 1276 DNREQQHFLQDCH----ELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAAN 1329
E + L +LK W+ EK M++ + L+T+ Q+ Q + E A
Sbjct: 2573 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATR 2632
Query: 1330 KDWLDKVDKEGRELTL---EKPELKALVSEKLRDLHRRWDEL--------ETTTQAKARS 1378
K +++ G+ + E P L+ +V E+L + ++WD L + QA +S
Sbjct: 2633 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2692
Query: 1379 LFDANRAELFAQSCCALESWL-ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
+ + L++ L SL H D ++N L+ Q ++ E+ +K
Sbjct: 2693 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD-------AMNQQLETAQKMKQEIQQEKK 2745
Query: 1438 EVEAIQA---QAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ-ASREQHQF 1493
+++ QA AL +E+ E+ R + + F+ + Q + LQ A HQF
Sbjct: 2746 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2805
Query: 1494 HRDVEDEILWV-TERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI--QGH--EPRIAD-- 1546
+ D W+ T++ S L ++ L+K ++ K + Q H E IA+
Sbjct: 2806 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
Query: 1547 -LRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAWM 1604
L + + AA +L ++ W +++ R +L+++L Y++ E W+
Sbjct: 2866 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2925
Query: 1605 GEQELHM----------MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDM 1654
+ + ++ G+ S Q E+ +H + + L + A ++ + +++
Sbjct: 2926 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2985
Query: 1655 IDHEHP---ESTRISIRQAQVDKL-YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
+ E+ + + Q K + + E +E +E R Q +E D+ +
Sbjct: 2986 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3045
Query: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
+ +++TML+ + + + +VD A LA L+ ++
Sbjct: 3046 GSQ---------AYSNKYLTMLQTQQKSLQ-----ALKHQVDLAKRLAQDLVVEASDSKG 3091
Query: 1771 T--VAEWKDSLNEAWADLLELLDTRGQVLAAAYE-LQRFLHGARQALARVQHKQQQLPD- 1826
T V +++ + + L + +D + L + + F + R+ ++ +L
Sbjct: 3092 TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSM 3151
Query: 1827 -GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEE-------- 1877
GRD AE LQ++ + I+A +++ + K A E
Sbjct: 3152 APVGRD---AETLQKQ----KETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVG 3204
Query: 1878 IGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF-RFFKAVRELMLWMDEVNLQMDAQERP 1936
I R ++A+++ +L + AR + + T + F+ ++E + + + + +E
Sbjct: 3205 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE---EHEESQ 3261
Query: 1937 RDVSSADLVIKNQQGI-----KAEIEARADRFSSCIDMGKELL--ARSHYAAEEISEKLS 1989
V I Q + K EIE + +G+ L+ A + + + L
Sbjct: 3262 GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD 3321
Query: 1990 QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAE---AWLCSQEPLV 2036
+ AR + +K ++ LQ L L GR E +W+ E LV
Sbjct: 3322 DVNARWKTLNKKVAQRAAQLQEAL--LHCGRFQDALESLLSWMVDTEELV 3369
Score = 106 bits (264), Expect = 3e-22
Identities = 329/1810 (18%), Positives = 700/1810 (38%), Gaps = 208/1810 (11%)
Query: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
++ I W+ K ERE L+ E LE+ A ++ + W+ + Q + +
Sbjct: 2883 LNTIKTNWDTFNKQVKERENKLK------ESLEK-ALKYKEQVETLWPWIDKCQNNLEEI 2935
Query: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
F L+ A E ++ K ++++ ++ + G V+ ++ A L + D + + ++ +
Sbjct: 2936 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2995
Query: 512 LWDFLRQMVAARRERLLLNLELQKVFQ--------------------DLLYLMDWMEEMK 551
D + + + +++ L + K FQ D L + +
Sbjct: 2996 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3055
Query: 552 GRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL 611
LQ+Q + L ++ + L + + D+ V+A + S L+ +E+ Q
Sbjct: 3056 TMLQTQQ--KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ- 3112
Query: 612 VSERVAKLEQSYEALCELAAARRARLEE--------------SRRLWRFLWEVGEAEAWV 657
V E+ + LE + + R + R + +A++
Sbjct: 3113 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
Query: 658 REQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQ 717
++ + L+AS D T + L + T+ ++ G L+ +Q +L+ +
Sbjct: 3173 KKLEALMASNDNANK-TCKMMLATEETS--PDLVGIKRDLEALSKQCNKLL-------DR 3222
Query: 718 ASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGH 777
A AR +++ +RLE E +L + + L Q + + + P
Sbjct: 3223 AQAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEESQG-----------PVGME 3267
Query: 778 DEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLE---RHY 834
E Q L +EEI + + L + +++ QG L+ +
Sbjct: 3268 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3327
Query: 835 EELQARAGERARALEAAL--------ALYTMLSEAGACGLWVEEKEQWLNGLALPERLED 886
+ L + +RA L+ AL AL ++LS W+ + E+ + P +
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLS-------WMVDTEELVANQKPPSA--E 3378
Query: 887 LEVVQ---QRFETLEPEMNTLAAQITAVNDIAEQLLK-ANPPGKDRIVNTQEQLNHRWQQ 942
+VV+ Q + L+ ++ + + + E++ A P K +I+ L+ RW+
Sbjct: 3379 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3438
Query: 943 FRRLADGKKAALTS-ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKL 1001
A+ + L ++ Q +H W+ K + + + +G + + +
Sbjct: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498
Query: 1002 AGTERDLEAIAARVGELTREANALAAGHPAQAVA-------INARLREVQTGWEDLRATM 1054
E D+ + A++ G + ++ + ++L Q + +++
Sbjct: 3499 KALEDDI------INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKS 3552
Query: 1055 RRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVA--SEEGPATLPEAEALLAQHAALR 1111
R E L +A + F + WL ++ S + +T E L Q + LR
Sbjct: 3553 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST----EGLWKQQSELR 3608
Query: 1112 ---GEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
++ + + G E+ + + L ++ +LEA+ ++++ ++ L
Sbjct: 3609 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668
Query: 1169 AQAHGFQGFLRDARQA---------EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMS 1219
QA L + +LS + VL E K+ ++ +
Sbjct: 3669 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3728
Query: 1220 TMDANGERIHGLLEAG--------RQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFL 1271
+D+ E LLE ++V+E N ++ R +D+I ++ ++ A +
Sbjct: 3729 LLDSLNEVSSALLELVPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILR-- 3783
Query: 1272 GRLRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAA 1328
Q F Q WI E K+++ D+ ++ + + Q + F E+
Sbjct: 3784 --------SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3834
Query: 1329 NKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAEL 1387
+KD +D + K G ++ T E K + +KL + + +D T Q + RA+
Sbjct: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYD---TICQINSERYLQLERAQS 3891
Query: 1388 ----FAQSCCALESWL---ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE 1440
F ++ L WL +S+ +QL + + ++ ++ + L +A + ++
Sbjct: 3892 LVNQFWETYEELWPWLTETQSIISQLPAP--ALEYETLRQQQEEHRQLRELIAEHKPHID 3949
Query: 1441 AIQAQAKALAQEDQGAG-EVERTSRAVEEKFRALCQPMRERCRRL-QASREQHQFHRDVE 1498
+ L + G G ++ A + + + + +++R L +A + QFH D
Sbjct: 3950 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFH-DKI 4008
Query: 1499 DEILWVTERL------PMASSMEHGK------DLPSVQLLMKKNQTLQKEI-QGHEPRIA 1545
D+IL ER+ P + S E K + +V + M+K Q L + + Q E IA
Sbjct: 4009 DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4068
Query: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWM 1604
+ + A A +L ++ +W+ + +E R +L D + A++F+ D +
Sbjct: 4069 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTI 4128
Query: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQ-----LAASSQDMIDHEH 1659
+ + + E + S VK+ Q + + + + + + S+ +
Sbjct: 4129 KDTQDFIRDLEDPGIDPSV---VKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGE 4185
Query: 1660 PESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC-QLRRELDDLEQWIQ-EREVVA 1717
P+ + +++ + L + +R ++L+E ++ Q + L + W+ +A
Sbjct: 4186 PDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA 4245
Query: 1718 ASHELGQDYEHVTMLRDKFREFSRDT--STIGQERVDSANALANGLIAGGHAARATVAEW 1775
+ +G D E V ++ ++F + I ER++ L + + + TV +
Sbjct: 4246 SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE-ESDKHTVQDP 4304
Query: 1776 KDSLNEAWADLLELLDTRGQVLAAAY-ELQRFLHGARQALARVQHKQQQLPDG--TGRDL 1832
L W L E + R L A L +F H + LA + H + L + G D
Sbjct: 4305 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4364
Query: 1833 NAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
A E +H ++D+ A V+ V G+ L ++ AG++A + ++ + + W +
Sbjct: 4365 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4424
Query: 1893 QGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
+ R+Q L + + F + +L W+ + + A + + K Q
Sbjct: 4425 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS---KPLGGLPETAKEQLN 4481
Query: 1952 IKAEI----EARADRFSSCIDMGKELLARSHYAAE-EISEKLSQLQARRQETAEKWQEKM 2006
+ E+ EA+ + + S + G+++LAR +AE I + ++ L+ + + K E+
Sbjct: 4482 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4541
Query: 2007 DWLQLVLEV-LVFGRDAGMAEAWLCSQEPLVRSAEL-GCTVDEVESLIKRHEAFQKSAVA 2064
L+ L + + F WL E + A +D V I H+ F +
Sbjct: 4542 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4601
Query: 2065 WEERFCALEK 2074
E+ L+K
Sbjct: 4602 HREQIIELDK 4611
Score = 68.9 bits (167), Expect = 6e-11
Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 16/282 (5%)
Query: 535 KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASA 594
K QDLL +W++EM+ +L + G L VE L+ H+ V I ++ S
Sbjct: 646 KFVQDLL---NWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 702
Query: 595 LRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAE 654
++ P K +E++ +LE Y L + + L+ L F+
Sbjct: 703 IQMTAPLK-------LTYAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNEL 752
Query: 655 AWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG 714
W+ E++ + D T R + H L E+ + +K E +QL+ E HP
Sbjct: 753 IWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 812
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAW---LVDALRLVS 771
A A +Q QW + L + Q + + + ++F DA + + L DA++
Sbjct: 813 RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKY 872
Query: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL 813
S + + L ++ +EE+ ++ T+ L +A +
Sbjct: 873 SCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 914
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/266 (18%), Positives = 109/266 (40%), Gaps = 24/266 (9%)
Query: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPES 1662
W+ E ++ + E D S ++ ++ H+ + +A+ ++ ++ + S M P
Sbjct: 654 WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLK 710
Query: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLEQWIQEREVVAASHE 1721
+ + +++ YA L + + L H + + EL W+ E+E +++
Sbjct: 711 LTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELI----WLNEKEEEEVAYD 766
Query: 1722 LGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNE 1781
+ ++ +D E R+ +E + S +A L+ H AR T+ ++ ++
Sbjct: 767 WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 825
Query: 1782 AWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRR 1841
W+ +L+L Q + F + A++A ++ N +A+QR+
Sbjct: 826 QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR--------------NLKDAIQRK 871
Query: 1842 H-CAYEHDIQALSPQVQQVQDDGHRL 1866
+ C I L VQ+ ++ L
Sbjct: 872 YSCDRSSSIHKLEDLVQESMEEKEEL 897
Score = 45.8 bits (107), Expect = 5e-04
Identities = 52/280 (18%), Positives = 110/280 (39%), Gaps = 28/280 (10%)
Query: 296 VLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSF-NSYRTVE 354
+LD + E + K+ +LL W+++ V L+ + + L V++ L++ N +R +E
Sbjct: 633 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 689
Query: 355 KPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALR 414
+ ++ + + T KL Y E+L + E + L
Sbjct: 690 EFESSLKEAKISEIQMTAPLKL------TYA--------------EKLHRLESQYAKLLN 729
Query: 415 TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDI 474
T ++ L+ L F +A WL+E + ++ + H + ++
Sbjct: 730 TSRNQERHLDTLH-NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 788
Query: 475 VAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534
+++V +A +L E + I A + + W ++ Q+ + + N
Sbjct: 789 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 848
Query: 535 KVFQDLLYLMDWMEEMKGRLQ---SQDLGRHLAGVEDLLQ 571
+ F D D++ +K +Q S D + +EDL+Q
Sbjct: 849 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ 888
Score = 45.8 bits (107), Expect = 5e-04
Identities = 205/1138 (18%), Positives = 417/1138 (36%), Gaps = 193/1138 (16%)
Query: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064
+++LE + +G +T + + A + R E+ +++ + +
Sbjct: 1153 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLR-SELNVVLQNMNQVYSMSSTYIDKL 1211
Query: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSR 1123
+ + L++ +A + +T + EE A E L++ R EV+ + +
Sbjct: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF-- 1269
Query: 1124 LRALGEEVTRDQADPQCLFLRQRLEALGTGW-----EELGRMWESRQGRLAQAHGFQGFL 1178
AL +E+ + +A +F + L W ++L W++ ++
Sbjct: 1270 -HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR------- 1321
Query: 1179 RDARQAEGVLSSQEYVL-SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQ 1237
R EG+ S +Y ++ + +Q + +K+++ N + + L +
Sbjct: 1322 --LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQE---NQPENSKTLATQLNQQKM 1376
Query: 1238 LVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ---HFLQDCHELKLWI 1294
LVSE + K+ E Q A+Q+ ++D Q + D +
Sbjct: 1377 LVSEIEMKQSKMDEC-----------QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1425
Query: 1295 DEKMLTAQDVSYDEARNLHTKWQKHQAFMAE-LAANKDWLDKVDKEGRELTLEKPELKAL 1353
+M ++ D+ E +L T++ M + + D L ++++E + L EK E
Sbjct: 1426 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHV-- 1483
Query: 1354 VSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK 1413
EK ++L + + T L DA +A S + + S + + +
Sbjct: 1484 --EKAKELQKWVSNISKT-------LKDAEKAGKPPFS----KQKISSEEISTKKEQLSE 1530
Query: 1414 DLTSVNILLKKQ--QMLEWEMAVREKEVEAIQAQAKAL-------AQEDQGAGEVERTSR 1464
L ++ + L K +M + E EK+V+ +Q L QE Q +G+V+ +
Sbjct: 1531 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK 1590
Query: 1465 AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQ 1524
V E+ + + ++ C L + + H++ + G ++
Sbjct: 1591 IVAERQQEYKEKLQGICDLLTQTENRLIGHQE----------------AFMIGDGTVELK 1634
Query: 1525 LLMKKNQTLQKEIQGHEPRIAD--------LRERQRALG---AAAAGPELAELQEMWKRL 1573
K + LQK++QG +A+ L+E L A +L E + ++L
Sbjct: 1635 KYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1694
Query: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL------SAQAEV 1627
+ E K L+ + ++ E A + + E E D L S +A
Sbjct: 1695 NLKAEQSKKELDKVVTTA--IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1752
Query: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPEST---RISIRQAQVDKLYAGLKE--- 1681
K QV+EQ + + + A +D ++ E+ ++ Q +++ Y +K
Sbjct: 1753 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1812
Query: 1682 --------------------------LAGERRERLQEHLRLCQ----------------- 1698
L+ E +E+LQ++++ +
Sbjct: 1813 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1872
Query: 1699 --LRRELD-------DLEQWIQEREVVAASHELGQDYEHVTMLR-DKFREFSRDT----- 1743
L+ EL+ + E W+Q+ E + E G D + M + + + FS D
Sbjct: 1873 HSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG 1932
Query: 1744 ----STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLA- 1798
TI RV A + G AT E + L+ A D L ++ VL
Sbjct: 1933 DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA-TDRFRSLYSKCNVLGN 1991
Query: 1799 ----AAYELQRFLHGARQALARVQ--------HKQQQL---PDGTGRDLNAAEALQRRHC 1843
+ Q + + LA +Q H + + P R L +ALQ +
Sbjct: 1992 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2051
Query: 1844 AYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQ-L 1902
+ + ++ L + + D L A +I + + + + L S R + L
Sbjct: 2052 SQQVAVEKLKKTAEVLLDARGSLLPA-----KNDIQKTLDDIVGRYEDLSKSVNERNEKL 2106
Query: 1903 LLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ-ERPRDVSSADLVIKNQQGIKAEIEARAD 1961
+ T + E++ WM V + Q + P + ++ +I ++ +I R
Sbjct: 2107 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2166
Query: 1962 RFSSCIDMGKELLARSH-YAAEEISEKLSQLQARRQETAEKWQE---KMDWLQLVLEV 2015
++ + K+ + + A + K+ L AR E + K +E KM+ L+ +E+
Sbjct: 2167 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL 2224
Score = 43.1 bits (100), Expect = 0.003
Identities = 62/299 (20%), Positives = 118/299 (39%), Gaps = 36/299 (12%)
Query: 1378 SLFDANRAE-----LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML---- 1428
SL D N E F Q L +W++ +Q QL ++G DL SV L+ + +
Sbjct: 632 SLLDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 688
Query: 1429 -EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQAS 1487
E+E +++E ++ IQ A E+ R +E ++ L R + R L
Sbjct: 689 EEFESSLKEAKISEIQMTAPLKLT------YAEKLHR-LESQYAKLLNTSRNQERHLDT- 740
Query: 1488 REQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL 1547
H F +E++W+ E+ + + + ++ + L +E+ E I +
Sbjct: 741 --LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSV 798
Query: 1548 RERQRALGAAAAGPEL------AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
+E L L A +Q W + + + +++ +F+ DA EA
Sbjct: 799 QEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 858
Query: 1602 AWMGEQELHMMGQEKAKDELSAQAE-----VKKHQVLEQALADYAQTIHQLAASSQDMI 1655
++ + L Q K + S+ V++ ++ L Y TI L ++ +I
Sbjct: 859 DYL--RNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 915
Score = 40.8 bits (94), Expect = 0.016
Identities = 37/205 (18%), Positives = 84/205 (40%), Gaps = 16/205 (7%)
Query: 1497 VEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGA 1556
V+D + WV E E G DLPSV+ ++ ++ + + I+ E + + + + +
Sbjct: 648 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM-- 705
Query: 1557 AAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRD--------AAEAEAWMGEQE 1608
A L+ + H LE + +L + R Q+ + D A W+ E+E
Sbjct: 706 ------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKE 759
Query: 1609 LHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIR 1668
+ + ++ + + H L + L + I + ++ ++ HP I
Sbjct: 760 EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 819
Query: 1669 QAQVDKLYAGLKELAGERRERLQEH 1693
+A + ++ + +L + ++E+
Sbjct: 820 RAAMQTQWSWILQLCQCVEQHIKEN 844
Score = 40.4 bits (93), Expect = 0.021
Identities = 44/225 (19%), Positives = 86/225 (38%), Gaps = 5/225 (2%)
Query: 758 DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTL 817
D+ W+ + + E G D S ++ H+ + I +L + + L
Sbjct: 650 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPL 709
Query: 818 SRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNG 877
T ++ LE Y +L + + R L+ L+ +S A +W+ EKE+
Sbjct: 710 KLT--YAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVA 764
Query: 878 LALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLN 937
ER ++ + L E++ I +V +IAEQLL N P + I + +
Sbjct: 765 YDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQ 824
Query: 938 HRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIE 982
+W +L + + + + + E ++R I+
Sbjct: 825 TQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 869
Score = 33.5 bits (75), Expect = 2.6
Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 8/100 (8%)
Query: 1914 KAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGK-- 1971
K V++L+ W+DE+ +Q+D E D+ S + ++N + + IE F S + K
Sbjct: 646 KFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE----EFESSLKEAKIS 701
Query: 1972 --ELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++ A E +L A+ T+ + +D L
Sbjct: 702 EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL 741
Score = 32.0 bits (71), Expect = 7.5
Identities = 105/572 (18%), Positives = 223/572 (38%), Gaps = 70/572 (12%)
Query: 1565 ELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE-AEAWMGE--------QELHMMGQE 1615
+L E W+ + +++ R + LE ++ ++YRD + W+ + QE +
Sbjct: 1306 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 1365
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQT-IHQLAASSQD----------MIDHEHPESTR 1664
+L+ Q + ++Q+ D Q Q +A+ +D M+D + +
Sbjct: 1366 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1425
Query: 1665 ISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQ 1724
Q+ D + +L R L ++ D L++ +E + + +
Sbjct: 1426 RRRMQSSADLIIQEFMDL--RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK--- 1480
Query: 1725 DYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWA 1784
EHV +K +E + S I + D+ A + + ++ K+ L+EA
Sbjct: 1481 --EHV----EKAKELQKWVSNISKTLKDAEKA-GKPPFSKQKISSEEISTKKEQLSEALQ 1533
Query: 1785 DLLELLDTRGQVLA--AAYELQRFLHGARQA--LARVQHKQQQLPDGTGRDLNAAEAL-Q 1839
+ L G + EL++ + +++ L + +Q T D+ E +
Sbjct: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1593
Query: 1840 RRHCAYEHDIQALSPQVQQVQDDGHRLQKAY-AGDKAEEIGRHMQAVAEAWAQLQGSSAA 1898
R Y+ +Q + + Q ++ Q+A+ GD E+ ++ E +QGS+ A
Sbjct: 1594 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1653
Query: 1899 RRQLLLDT-------------TDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLV 1945
+++ +T DK + + E + +++NL+ + ++ D +
Sbjct: 1654 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1713
Query: 1946 IKNQQGIKA--EIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQ 2003
+ + + A ++E + + +D + S A + + + Q QE K
Sbjct: 1714 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1773
Query: 2004 --EKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS 2061
E+ + +LE V G+ G + L Q V++ + E +I +H+A
Sbjct: 1774 IGEEDEVNGNLLETDVDGQ-VGTTQENLNQQYQKVKA--------QHEKIISQHQAV--- 1821
Query: 2062 AVAWEERFCALEK---LTALEEREKERKRKRE 2090
+A + LEK + EE+EK +K +E
Sbjct: 1822 IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1853
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 315 bits (806), Expect = 4e-85
Identities = 182/406 (44%), Positives = 250/406 (61%), Gaps = 15/406 (3%)
Query: 51 LADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGR 110
+ADER+ VQKKTFTKW+N HL +V V DLY DLRDG NL+ LLEVLSG+ LP+ KGR
Sbjct: 207 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 265
Query: 111 MRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETE 170
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V E
Sbjct: 266 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 325
Query: 171 DNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKK 230
E SAK+ LLLW Q T GY + NFTT WRDG FNAI+HK+RPDL+D ++
Sbjct: 326 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 383
Query: 231 CNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEG 290
+ NL++AF +AEK +G+ +LLDPEDV+V PDEKS+ITYV++ Y F K+ G
Sbjct: 384 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 439
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSY 350
+ IG A + E +Y+++ + L+QWI + T+++R N+ ++ + +
Sbjct: 440 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 494
Query: 351 RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERE 410
+ E PPK TEK ++ L ++ + K+ +G +DI K W +L A ERE
Sbjct: 495 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 551
Query: 411 LALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLE 456
ALR E+ R E L+Q+A R R + + E L + D+ LE
Sbjct: 552 KALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE 597
Score = 159 bits (403), Expect = 2e-38
Identities = 343/1769 (19%), Positives = 687/1769 (38%), Gaps = 166/1769 (9%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTI-VTLNDRQLANSLSGVQNQLQSFNS 349
K++ + EA +++ LL W+ T + N + + V+ Q+Q
Sbjct: 3470 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL 3529
Query: 350 YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHER 409
+ + K T +EV+ + +K+ T E +D K ++L +
Sbjct: 3530 LQRLLDDRKST----VEVI--------KREGEKIATTAEP---ADKVKILKQLSLLDSRW 3574
Query: 410 ELALRTELIRQEKLEQL---AARFDRKAAMRETWLSE-NQRLVSQDNFGLELAAVEAAVR 465
E L R +LE + A +F WL+ +RLV+ + G + + +E +
Sbjct: 3575 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3634
Query: 466 KHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDF-LRQMVAARR 524
+H+A+E DI+ ++ + ++ L + K + + + +++W +++ +R
Sbjct: 3635 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3694
Query: 525 ERLLLNLELQKVF-QDLLYLMDWMEEMKGRLQSQDLGRHLA-GVEDLLQLHELVEADIAV 582
E L L K+F +D + LM+W+ E+ +L + + G+ +++ DI +
Sbjct: 3695 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3754
Query: 583 QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642
+ + V + L K+ + ++ +++ ++ Y+ + +L+ LE++ +
Sbjct: 3755 RKQNVDQALLNGLELL---KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3811
Query: 643 LWRFLWEVGEAEA-WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTL 701
L R L E W+ + + L S +T ++L A + +M R LK
Sbjct: 3812 LARRLHSTHEELCTWLDKVEVELLSYET--------QVLKGEEASQAQM--RPKELKKEA 3861
Query: 702 EQGQQLVAEGHPGASQASARAAELQAQW---ERLEALAEERAQRLA-------------Q 745
+ + L+ ++ S+ EL W E LE + E +R
Sbjct: 3862 KNNKALL----DSLNEVSSALLEL-VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3916
Query: 746 AASLYQFQAD-ANDME-AWLVDA-LRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPT 802
AA L Q D A D E +W+ + +L+S ++ ++ T A + + EI H+
Sbjct: 3917 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3976
Query: 803 LDALREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSE 860
+D L + + S + ++ ++ + ++Y+ + ER LE A +L E
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 4036
Query: 861 A-GACGLWVEEKEQWLNGLALPE-RLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918
W+ E + ++ L P E L Q+ L + I +N QL
Sbjct: 4037 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 4096
Query: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN-YHLECTETQAWMREK 977
L+ +P I + + Q + + AL A+S +H + + +
Sbjct: 4097 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LESL 4153
Query: 978 TKVIESTQGLGNDLAGVLALQRKLAGTER---DLEAIAARVGELTREANALAA-----GH 1029
+++E + + A V ++ +++ + D+E + L + + A
Sbjct: 4154 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4213
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQD-FLRSLDDFQAWLGRTQTAV 1088
A A+ +L ++ WE++ + RE L + L + F + TQ +
Sbjct: 4214 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4273
Query: 1089 ASEEGPATLPEAEALLAQHA-ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147
E P P + A +R E++ Q E + LG E+ +P +++ +
Sbjct: 4274 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4333
Query: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA--EGVLSSQEYVLSHTEMPGTLQ 1205
+ L + W+ L + W+ R +L +A +D QA + V + + S + + L+
Sbjct: 4334 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4393
Query: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK---------IREKADSI 1256
I++L+ F S + L L+ + +DK ++ DS+
Sbjct: 4394 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4453
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWI--DEKMLTAQDVSYDEARNLHT 1314
E R Q + G L + QH L EL W+ E +L+ Q + + +
Sbjct: 4454 EERIINRQHKLE---GALLALGQFQHALD---ELLAWLTHTEGLLSEQKPVGGDPKAIEI 4507
Query: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP-ELKALVSEKLRDLHRRWDE-LETTT 1372
+ KH ++ A++ ++ V+K G +L E + + KL L++RW LE T
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4567
Query: 1373 QAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEM 1432
Q K + +A+ F L+ WL + L + K L + K+Q + E+
Sbjct: 4568 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVHMEV 4624
Query: 1433 AVREKEVEAIQAQAKALAQEDQ---------GAGEVERTSRAVEEKFRALCQPMRERCRR 1483
EA + K+L Q+ Q +++ ++EK+ ++ + ER +
Sbjct: 4625 CA---AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4681
Query: 1484 L-QASREQHQFHRDVEDEILWVTE-RLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHE 1541
L +A +FH ++D I W+T+ + + L +V + +++ E+ H
Sbjct: 4682 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4741
Query: 1542 PRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDA-LRAQQF 1593
+I +L + L + + L +Q W+++ L RG+ L+DA RA+QF
Sbjct: 4742 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4801
Query: 1594 YRDAAEAEAWMGEQELHMMGQ-EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQ 1652
+ ++ W+ E E + + E A D + ++ +H+ +++L + +
Sbjct: 4802 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4861
Query: 1653 DMIDHEHPESTRISIRQAQVDKLYAGLKE----LAG---ERRERLQEHLRLC-QLRRELD 1704
+ E T ++ ++D + + L++ + G ER+ +L+E L Q L
Sbjct: 4862 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQ 4916
Query: 1705 DLEQWIQERE-VVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL---ANG 1760
L W+ E +A + D + V L D + F ++ +R S AL A
Sbjct: 4917 ALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELG----KRTSSVQALKRSARE 4972
Query: 1761 LIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHK 1820
LI G + V L+ W + L ++ L AA H AL +
Sbjct: 4973 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE 5032
Query: 1821 QQQ-------LPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
+Q LPD D +A L +H + ++ ++ + G + D
Sbjct: 5033 AEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 5088
Query: 1874 KAEEIGRHMQAVAE------AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927
I + + AWA+ A L K +A+ + W +
Sbjct: 5089 SITTIKHWITIIRARFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTL 5146
Query: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEI 1956
D + P+++ +I Q E+
Sbjct: 5147 TDKDKEVIPQEIEEVKALIAEHQTFMEEM 5175
Score = 129 bits (325), Expect = 3e-29
Identities = 339/1876 (18%), Positives = 719/1876 (38%), Gaps = 160/1876 (8%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLN---DRQLANSLSGVQNQL--Q 345
K+ K+LD A E VE E +++ + L + + + G++ + Q
Sbjct: 3352 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3411
Query: 346 SFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKA 405
N ++ +K +G + + + Q +++ + T + D+N W+ L K
Sbjct: 3412 QLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK 3471
Query: 406 EHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV-SQDNFGLELAAVEAAV 464
+R L+ L+ RF +W+ + + LV +Q E V+A +
Sbjct: 3472 VAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQI 3524
Query: 465 RKHEAIETDIVAYSGRVQAVDAVAAELA--AERYHDIKRIAARQHNVARLWDFLRQMVAA 522
++ + ++ + V+ + ++A AE +K I + + W+ L
Sbjct: 3525 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSRWEALLNKAET 3583
Query: 523 RRERLL-LNLELQKVFQDLLYLMDWMEEMKGRL-QSQDLGRHLAGVEDLLQLHELVEADI 580
R +L +++ Q+ + L L +W+ ++ RL + +G + +E+ + H+ +E DI
Sbjct: 3584 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3643
Query: 581 AVQAERV-RAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEE 639
+ + +AVS +E D +V ++ + Y + E + +R L++
Sbjct: 3644 INHNKHLHQAVSIGQSLKVLSSRE----DKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3699
Query: 640 SRRLWRFLWE-VGEAEAWVREQQHLLASADTGRDLT-------GALRLLNKHTALRGE-- 689
+ + E E W+ E L+ T LR+L + LR +
Sbjct: 3700 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3759
Query: 690 ---MSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+ L LK T ++ + + ++A+++ + L+ + A+ L QA
Sbjct: 3760 DQALLNGLELLKQTTGDEVLIIQD----------KLEAIKARYKDITKLSTDVAKTLEQA 3809
Query: 747 ASL-YQFQADANDMEAWL--VDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803
L + + ++ WL V+ L ++ E ++QA R + L++E ++++ L
Sbjct: 3810 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNNKALL 3868
Query: 804 DALREQAAALPPTLS-RTPE-VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861
D+L E ++AL + R E ++ V Y + ++ ++AA+ +A
Sbjct: 3869 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3928
Query: 862 GACGL-WVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK 920
L W+ E E+ L L D+ + Q + T +I DI + L+K
Sbjct: 3929 ADAELSWITETEKKLMSLG------DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3982
Query: 921 A--------NPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC-TETQ 971
+ + K + +++ + ++ + L A S+ N E E
Sbjct: 3983 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 4042
Query: 972 AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
W+ E +I + + Q + + + ++ + L P
Sbjct: 4043 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 4102
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEA-RRLQDFLRSLDDFQAWLGRTQTAVAS 1090
+ +I + T + ++ +++R +L EA + F +D L R +
Sbjct: 4103 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL-- 4160
Query: 1091 EEGPATLPEAEAL---LAQHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFL 1143
+ P+ E E + ++++ + ++E+ Q Y L+ GEE+ D +
Sbjct: 4161 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4220
Query: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGF-QGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
+ +L+ + WE + + E R+ +L + F D + + + E PG
Sbjct: 4221 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4280
Query: 1203 -----TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSE-GNIHADKIREKADSI 1256
Q +AA E +D E + ++ G +L++ G +++ D +
Sbjct: 4281 IDPSVVKQQQEAA----ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4336
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKL-WID---EKMLTAQDVSYDEARNL 1312
A + + +L + + QD + W+D K+ + + D +
Sbjct: 4337 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD-LETV 4395
Query: 1313 HTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK---PELKALVSEKLRDLHRRWDELE 1369
+ ++ + F +E + +++++ + EL L+K K V + L +L WD LE
Sbjct: 4396 KQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4454
Query: 1370 TTTQAKARSLFDANRA-ELFAQSCCALESWLESLQAQL-HSDDYGKDLTSVNILLKKQQM 1427
+ L A A F + L +WL + L G D ++ I L K +
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4514
Query: 1428 LEWEMAVREKEVEAIQAQAKALAQEDQG--AGEVERTSRAVEEKFRALCQPMRERCRRLQ 1485
L+ ++ + VEA+ L + G A ++ + ++++ + + +R ++L
Sbjct: 4515 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4574
Query: 1486 -ASREQHQFHRDVEDEILWVTE-------RLPMASSMEHGKDLPSVQL-----LMKKNQT 1532
A R+ FH ++ED W+T+ P+ E K+ +V + K +T
Sbjct: 4575 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4634
Query: 1533 LQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQ 1591
+ +Q + +A R ++ L+E W+ + +L R +LE+AL A
Sbjct: 4635 YKSLMQKGQQMLA----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4690
Query: 1592 QFYRDAAEAEAWM--GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAA 1649
+F+ + W+ EQ L++ + + + ++ +H+V + + + I +L
Sbjct: 4691 EFHNSLQDFINWLTQAEQTLNVASRPSLILD-TVLFQIDEHKVFANEVNSHREQIIELDK 4749
Query: 1650 SSQDM-IDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLE 1707
+ + + + I V + + + ER L + R Q L
Sbjct: 4750 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4809
Query: 1708 QWIQEREVVAASH-ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGH 1766
+W++E E S E+ D + + + +EF + D+ N L
Sbjct: 4810 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA-KHSVYDTTNRTGRSL----- 4863
Query: 1767 AARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPD 1826
+ ++A+ L++ ++L + DT + + E Q L A + Q L D
Sbjct: 4864 KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDALQALID 4920
Query: 1827 GTGR-------------DLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
R D++ L H A++ ++ + VQ ++ L + + D
Sbjct: 4921 WLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRD 4979
Query: 1874 KAEEIGRHMQAVAEAW---AQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQM 1930
+ + MQ ++ W L S R + L ++F V L+ W+ E +
Sbjct: 4980 DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFH--SVVHALLEWLAEAEQTL 5037
Query: 1931 DAQ-ERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSH-YAAEEISEKL 1988
P D + +I + ++E + + MG +LA H + I +
Sbjct: 5038 RFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWI 5097
Query: 1989 SQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMA-EAWLCSQEPLVRSAE---LGCT 2044
+ ++AR +E ++ L L L+ ++ A AWL E + + +
Sbjct: 5098 TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE 5157
Query: 2045 VDEVESLIKRHEAFQK 2060
++EV++LI H+ F +
Sbjct: 5158 IEEVKALIAEHQTFME 5173
Score = 118 bits (296), Expect = 6e-26
Identities = 206/1008 (20%), Positives = 403/1008 (39%), Gaps = 91/1008 (9%)
Query: 399 WERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-DNFGLEL 457
WE + ERE L + +LA +F + + Q + ++ G++
Sbjct: 4231 WENIHTLVEEREAKLLDVM-------ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4283
Query: 458 AAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQ-HNVARLWDFL 516
+ V+ E I +I + V + +EL A K I + + WD L
Sbjct: 4284 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4343
Query: 517 RQMVAARRERLLLNLELQKVFQD-LLYLMDWMEEMKGRLQSQD-LGRHLAGVEDLLQLHE 574
+ R ++L ++ +QD L + DW++ G+L S +G L V+ ++ +
Sbjct: 4344 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4403
Query: 575 LVEADI---AVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
+++ ++ ER+ + L+ K D V + + +L+ +++L E
Sbjct: 4404 QFKSEAYQQQIEMERLNHQAELLLK-----KVTEESDKHTVQDPLMELKLIWDSLEERII 4458
Query: 632 ARRARLEESR-RLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTALRGE 689
R+ +LE + L +F + E AW+ + LL+ G D L KH L+ +
Sbjct: 4459 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4518
Query: 690 MSGRLGPLKLTLEQGQQLVAEGHPG--ASQASARAAELQAQWERLEALAEERAQRLAQAA 747
+ ++ + G L+ E G AS + L +W+ + E+R Q+L A
Sbjct: 4519 VLAHQSTVEAVNKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4577
Query: 748 SLYQ-FQADANDMEAWLVDALR-LVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDA 805
+ F + D++ WL D R L++S LG + + H + + T +
Sbjct: 4578 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4637
Query: 806 LREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGA 863
L ++ + ++ E + + L+ +E ++ + ER LE AL L +
Sbjct: 4638 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQ 4697
Query: 864 CGL-WVEEKEQWLNGLALPERLEDLEVVQ-QRFETLEPEMNTLAAQITAVNDIAEQLLKA 921
+ W+ + EQ LN + P + D + Q + E+N+ QI ++ L K
Sbjct: 4698 DFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL-KY 4756
Query: 922 NPPGKDRIV--NTQEQLNHRWQQF-RRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978
+D ++ N + RW++ +RL + ++ + + +H ++ W+ E
Sbjct: 4757 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4816
Query: 979 KVIESTQGLGND-------LAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
K ++S + ND LA Q+ L G + + R G +E +LA +
Sbjct: 4817 KSLDSELEIANDPDKIKTQLAQHKEFQKSL-GAKHSVYDTTNRTGRSLKEKTSLADDN-- 4873
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEAR----RLQDFLRSLDDFQAWLGRTQTA 1087
+ ++ L E++ W+ + R+ L EA + D L++L D WL R +
Sbjct: 4874 --LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID---WLYRVEPQ 4928
Query: 1088 VASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQR 1146
+A ++ + L+ H A + E+ + S L+ E+ D +++ +
Sbjct: 4929 LAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WVKVQ 4987
Query: 1147 LEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL--------SSQEYVLSHT 1198
++ L T WE + + S+Q RL A LR A + V+ +++ + H
Sbjct: 4988 MQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEAEQTLRFHG 5041
Query: 1199 EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKI--------- 1249
+P A I + ++FM ++ ++ G +++ H D I
Sbjct: 5042 VLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI--CHPDSITTIKHWITI 5099
Query: 1250 -REKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWID--EKMLTAQD--V 1304
R + + + K++Q Q+ L +Q L+ L W+ E LT +D V
Sbjct: 5100 IRARFEEVLAWAKQHQ---QRLASALAGLIAKQELLE---ALLAWLQWAETTLTDKDKEV 5153
Query: 1305 SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E + +HQ FM E+ + +DKV K + + L++
Sbjct: 5154 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5201
Score = 110 bits (275), Expect = 2e-23
Identities = 361/1905 (18%), Positives = 719/1905 (37%), Gaps = 278/1905 (14%)
Query: 362 KGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQE 421
K EVLL S L A N T + DI +E L K+ +ER L+ L R
Sbjct: 2199 KKTAEVLLDARGSLLPAKNDIQKT------LDDIVGRYEDLSKSVNERNEKLQITLTRSL 2252
Query: 422 KLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRV 481
++ D M + + L Q L A++ + K+ +E DI +
Sbjct: 2253 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2306
Query: 482 QAVDAVAAEL--------AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLEL 533
A++ + A+ +K ++AR + + A+ E L +EL
Sbjct: 2307 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK----HKETLAKMEELKTKVEL 2362
Query: 534 QKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSAS 593
F++L + E K +Q L +D+ +L + ++ + E + +
Sbjct: 2363 ---FENLSEKLQTFLETK----TQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVL 2415
Query: 594 ALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESR-RLWRFLWEVGE 652
P D LV E+ L + ++ + + ++ + + +L F V
Sbjct: 2416 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2475
Query: 653 AEAWVREQ-------QHLLASADTGRDLTGALRLLNKHTALRGEM--------------S 691
++W++E Q + D G+ L +L K + E+ S
Sbjct: 2476 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2535
Query: 692 GRLGPLKLTL---EQGQQLVAEG----------HPGASQASARAAELQAQWERLEALAEE 738
P K G L EG + G + ++ +E L L ++
Sbjct: 2536 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2595
Query: 739 RAQRL-AQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL---ARQHRALEE 794
+ L + + L + Q +++ M WL + + + T+A+ Q+++ E
Sbjct: 2596 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA 2655
Query: 795 EIRSHRPTLDALREQAAALPPTLSRTPEV---QGRVPTLERHYEELQARAGERARALEAA 851
E++ + + L+++ L TPE + + ++ ++EL +R + LE +
Sbjct: 2656 ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES 2715
Query: 852 LALYTMLSEAGA-CGLWVEEKEQWLNGLA--------LPERLEDLEVVQQRFETLEPEMN 902
T A W+ EKE ++ L L + + ++++ Q F T +P+
Sbjct: 2716 SNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE 2775
Query: 903 TLAAQITAVNDIAEQLLKANPPGKDRIVN--TQEQLNHRWQQFRRLADGKKAALTSALS- 959
L A + + PG+D + +EQL Q++ +LT LS
Sbjct: 2776 QLTAAGQGI---------LSRPGEDPSLRGIVKEQLAAVTQKWD--------SLTGQLSD 2818
Query: 960 ----IQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARV 1015
I ++ T+ Q+ +R + + L N L+ LA+ + LE
Sbjct: 2819 RCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK 2875
Query: 1016 GELTREANALAAGHPAQAVA--INARLREVQTGWEDLRATMRRREESL------------ 1061
E+ +E + AQA+ ++A ++E E L+A + R+ E +
Sbjct: 2876 QEIQQEKKQIKV---AQALCEDLSALVKE-----EYLKAELSRQLEGILKSFKDVEQKAE 2927
Query: 1062 GEARRLQD-------FLRSLDDFQAWLGRTQTAVASEEGP--ATLPEAEALLAQHAALRG 1112
+ LQ F + DFQAWL T+ ++ P A L E+L+ H
Sbjct: 2928 NHVQHLQSACASSHQFQQMSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2986
Query: 1113 EVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAH 1172
+ Y + A GE + + L+ +L + T W+ + + R+ +L ++
Sbjct: 2987 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES- 3045
Query: 1173 GFQGFLRDARQAEGV----------LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMD 1222
+ L+ Q E + L ++ L E ++ + K+++ ++
Sbjct: 3046 -LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 3104
Query: 1223 ANGERIHGLL---EAGRQLVSEGNIHADKIREKADSI-ERRHKKN---QDAAQQFLGRLR 1275
+ LL E +++V++ N + +K D + E+ H K ++ Q+F
Sbjct: 3105 LLNNTANSLLSVCEIDKEVVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE 3161
Query: 1276 DNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQ-----KHQAFMAELAANK 1330
++E + LQ C + +L I + L +Q S L T+ + KHQ +A+ A
Sbjct: 3162 VSKESKRQLQ-CAKEQLDIHDS-LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3219
Query: 1331 DWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDE----LETTTQA------KARSLF 1380
++ D +G L + E ++++ L ++ DE LET Q R +F
Sbjct: 3220 LVVEASDSKGTSDVLLQVE---TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMF 3276
Query: 1381 D---------------ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQ 1425
AE + ++++L+ L+A + S+D + + ++
Sbjct: 3277 SQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 3336
Query: 1426 QMLEWEMAVREKEVEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRL 1484
++ ++++EA+ Q L Q E VE T + +EE + L +E L
Sbjct: 3337 SP---DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL----KEFSILL 3389
Query: 1485 QASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRI 1544
Q + E + V E + ++L M + ++ L K Q + QG
Sbjct: 3390 QKAEEHEESQGPVGMETETINQQLNMFKVFQK----EEIEPLQGKQQDVNWLGQGL---- 3441
Query: 1545 ADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAW 1603
++ ++ +L ++ WK L ++ R +L++AL ++DA E+ +W
Sbjct: 3442 --IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3499
Query: 1604 MGEQELHMMGQEKAKDELS-AQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-E 1661
M + E + Q+ E +A++++ ++L++ L D T+ + + + P +
Sbjct: 3500 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC--QLRRELDDLEQWIQ--EREVVA 1717
+I + + +D + L A E R R E + + Q L+ L +W+ E+ +V
Sbjct: 3560 KVKILKQLSLLDSRWEALLNKA-ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLV- 3617
Query: 1718 ASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKD 1777
+ E + K E + + ++ L + G + E KD
Sbjct: 3618 -------NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3670
Query: 1778 ------SLNEAW-ADLLELLDTRGQVLAAA-----------YELQRFLHGARQALARVQH 1819
++ W ++ E +R ++L A EL +L+ L+++
Sbjct: 3671 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS- 3729
Query: 1820 KQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879
Q +G + + LQ DI V Q +G L K GD+ I
Sbjct: 3730 VQDYSTEGLWKQQSELRVLQ-------EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3782
Query: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAV-RELMLWMDEVNLQMDAQE---- 1934
++A+ + + S + L R + EL W+D+V +++ + E
Sbjct: 3783 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVL 3842
Query: 1935 RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQAR 1994
+ + S A + K +K E + S ++ LL + A E EK+
Sbjct: 3843 KGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE 3899
Query: 1995 R----QETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLC-SQEPLVRSAELGCTVDEVE 2049
R +T + E++D +L F + A +W+ +++ L+ ++ D+
Sbjct: 3900 RYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3957
Query: 2050 SLIKRHEAFQKSAVAWEERFCALEK-----LTALEEREKERKRKR 2089
+ ++ + F + ++ L K +TA E EK+ +K+
Sbjct: 3958 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 4002
Score = 108 bits (269), Expect = 8e-23
Identities = 343/1970 (17%), Positives = 756/1970 (38%), Gaps = 251/1970 (12%)
Query: 252 KLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGK--VLDHAMEAERLVEK 309
K L+ E+ ++++ ++K + + S + + ++ GK + +E + K
Sbjct: 1604 KRLEEEEKSLEE-EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1662
Query: 310 YESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFN-SYR-----TVEKPPKFTEKG 363
E L SE LQ I+ + D+ + ++ Q+++ SY ++++ + G
Sbjct: 1663 KEQL-SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1721
Query: 364 NLEVLLFTIQSKLRANNQKVY-----------TPREGRLISD-----INKAWERLEKAEH 407
+++V + K+ A Q+ Y T E RLI I L+K +
Sbjct: 1722 DVKV-----EEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1776
Query: 408 ERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467
++E EL Q+ ++ A E +L EN +SQ++ L + A K
Sbjct: 1777 KQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1829
Query: 468 EAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL------RQMVA 521
E + + V A + E+ +K++ + + L D+L +
Sbjct: 1830 EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1889
Query: 522 ARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDL-GRHLAGVEDLLQLHELVEAD- 579
+ ++++ D + +E+ G L D+ G+ E+L Q ++ V+A
Sbjct: 1890 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1949
Query: 580 ---IAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYE-ALCELAAARRA 635
I+ + A ++ + G+ P + + + + + +L+ YE AL E +
Sbjct: 1950 EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL 2009
Query: 636 RLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR-DLTGALRLLNKHTALRGEMSGRL 694
L +F + E E W+++ + L + + G D+ G + L + + ++
Sbjct: 2010 THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK 2069
Query: 695 GPLKLTLEQGQQLV------AEGHPGASQASARAAELQA-------QWERLEALAEERAQ 741
G L+ G +++ ++ G SA E+Q ++ L +
Sbjct: 2070 GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN 2129
Query: 742 RLAQAASLYQFQADAN-----DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
L YQ DA+ ++A A + +S P + D + Q + +AL+ +I
Sbjct: 2130 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP-IAVDPKNLQRQLEETKALQGQI 2188
Query: 797 RSHRPTLDALREQAAAL----PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAAL 852
S + ++ L++ A L L ++Q + + YE+L ER L+ L
Sbjct: 2189 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2248
Query: 853 ALYTMLSEAGACGLWVEEKEQWLNGL--------ALPERLEDLEVVQQRFETLEPEMNTL 904
+ + ++E W+ + +P L+ + + LE ++
Sbjct: 2249 TRSLSVQDG------LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2302
Query: 905 AAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS----ALSI 960
+ I A+N+ ++ ++ P + Q ++ +F + K L +
Sbjct: 2303 QSSINAMNEKVKKFMETTDP--STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2360
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT----ERDLEAIAARVG 1016
+ + + Q ++ KT+ + G D+ + ++ ++ LE + + +
Sbjct: 2361 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2420
Query: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLD 1075
E++ + G P+ + + + ++++ T++ ++E++ + +L F +
Sbjct: 2421 EIS------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVK 2474
Query: 1076 DFQAWLGRT-------QTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128
++W+ T Q + +E+ +L + + L + + E+++ + L L
Sbjct: 2475 SLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLI 2534
Query: 1129 EEVTRDQ--------------------------ADPQCLFLRQRLEALGTGWEELGRMWE 1162
VT A+ +++ + + G+E+LG + +
Sbjct: 2535 SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK 2594
Query: 1163 SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-------HTEMPGTLQAADAAIKKLE 1215
++A+ + L+ A++ + ++ T P +A +++ +
Sbjct: 2595 D---KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2651
Query: 1216 DFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLR 1275
F + + N ++ L + +L+ E + R K + K Q+ Q + R +
Sbjct: 2652 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK-QMLTEIDSKWQELNQLTIDRQQ 2710
Query: 1276 DNREQQHFLQDCH----ELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAAN 1329
E + L +LK W+ EK M++ + L+T+ Q+ Q + E A
Sbjct: 2711 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATR 2770
Query: 1330 KDWLDKVDKEGRELTL---EKPELKALVSEKLRDLHRRWDEL--------ETTTQAKARS 1378
K +++ G+ + E P L+ +V E+L + ++WD L + QA +S
Sbjct: 2771 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2830
Query: 1379 LFDANRAELFAQSCCALESWL-ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
+ + L++ L SL H D ++N L+ Q ++ E+ +K
Sbjct: 2831 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD-------AMNQQLETAQKMKQEIQQEKK 2883
Query: 1438 EVEAIQA---QAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ-ASREQHQF 1493
+++ QA AL +E+ E+ R + + F+ + Q + LQ A HQF
Sbjct: 2884 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2943
Query: 1494 HRDVEDEILWV-TERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI--QGH--EPRIAD-- 1546
+ D W+ T++ S L ++ L+K ++ K + Q H E IA+
Sbjct: 2944 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 3003
Query: 1547 -LRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAWM 1604
L + + AA +L ++ W +++ R +L+++L Y++ E W+
Sbjct: 3004 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 3063
Query: 1605 GEQELHM----------MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDM 1654
+ + ++ G+ S Q E+ +H + + L + A ++ + +++
Sbjct: 3064 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 3123
Query: 1655 IDHEHP---ESTRISIRQAQVDKL-YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
+ E+ + + Q K + + E +E +E R Q +E D+ +
Sbjct: 3124 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3183
Query: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
+ +++TML+ + + + +VD A LA L+ ++
Sbjct: 3184 GSQ---------AYSNKYLTMLQTQQKSLQ-----ALKHQVDLAKRLAQDLVVEASDSKG 3229
Query: 1771 T--VAEWKDSLNEAWADLLELLDTRGQVLAAAYE-LQRFLHGARQALARVQHKQQQLPD- 1826
T V +++ + + L + +D + L + + F + R+ ++ +L
Sbjct: 3230 TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSM 3289
Query: 1827 -GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEE-------- 1877
GRD AE LQ++ + I+A +++ + K A E
Sbjct: 3290 APVGRD---AETLQKQ----KETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVG 3342
Query: 1878 IGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF-RFFKAVRELMLWMDEVNLQMDAQERP 1936
I R ++A+++ +L + AR + + T + F+ ++E + + + + +E
Sbjct: 3343 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE---EHEESQ 3399
Query: 1937 RDVSSADLVIKNQQGI-----KAEIEARADRFSSCIDMGKELL--ARSHYAAEEISEKLS 1989
V I Q + K EIE + +G+ L+ A + + + L
Sbjct: 3400 GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD 3459
Query: 1990 QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAE---AWLCSQEPLV 2036
+ AR + +K ++ LQ L L GR E +W+ E LV
Sbjct: 3460 DVNARWKTLNKKVAQRAAQLQEAL--LHCGRFQDALESLLSWMVDTEELV 3507
Score = 106 bits (264), Expect = 3e-22
Identities = 329/1810 (18%), Positives = 700/1810 (38%), Gaps = 208/1810 (11%)
Query: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
++ I W+ K ERE L+ E LE+ A ++ + W+ + Q + +
Sbjct: 3021 LNTIKTNWDTFNKQVKERENKLK------ESLEK-ALKYKEQVETLWPWIDKCQNNLEEI 3073
Query: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
F L+ A E ++ K ++++ ++ + G V+ ++ A L + D + + ++ +
Sbjct: 3074 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 3133
Query: 512 LWDFLRQMVAARRERLLLNLELQKVFQ--------------------DLLYLMDWMEEMK 551
D + + + +++ L + K FQ D L + +
Sbjct: 3134 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3193
Query: 552 GRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL 611
LQ+Q + L ++ + L + + D+ V+A + S L+ +E+ Q
Sbjct: 3194 TMLQTQQ--KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ- 3250
Query: 612 VSERVAKLEQSYEALCELAAARRARLEE--------------SRRLWRFLWEVGEAEAWV 657
V E+ + LE + + R + R + +A++
Sbjct: 3251 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3310
Query: 658 REQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQ 717
++ + L+AS D T + L + T+ ++ G L+ +Q +L+ +
Sbjct: 3311 KKLEALMASNDNANK-TCKMMLATEETS--PDLVGIKRDLEALSKQCNKLL-------DR 3360
Query: 718 ASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGH 777
A AR +++ +RLE E +L + + L Q + + + P
Sbjct: 3361 AQAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEESQG-----------PVGME 3405
Query: 778 DEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLE---RHY 834
E Q L +EEI + + L + +++ QG L+ +
Sbjct: 3406 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3465
Query: 835 EELQARAGERARALEAAL--------ALYTMLSEAGACGLWVEEKEQWLNGLALPERLED 886
+ L + +RA L+ AL AL ++LS W+ + E+ + P +
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLS-------WMVDTEELVANQKPPSA--E 3516
Query: 887 LEVVQ---QRFETLEPEMNTLAAQITAVNDIAEQLLK-ANPPGKDRIVNTQEQLNHRWQQ 942
+VV+ Q + L+ ++ + + + E++ A P K +I+ L+ RW+
Sbjct: 3517 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3576
Query: 943 FRRLADGKKAALTS-ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKL 1001
A+ + L ++ Q +H W+ K + + + +G + + +
Sbjct: 3577 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3636
Query: 1002 AGTERDLEAIAARVGELTREANALAAGHPAQAVA-------INARLREVQTGWEDLRATM 1054
E D+ + A++ G + ++ + ++L Q + +++
Sbjct: 3637 KALEDDI------INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKS 3690
Query: 1055 RRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVA--SEEGPATLPEAEALLAQHAALR 1111
R E L +A + F + WL ++ S + +T E L Q + LR
Sbjct: 3691 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST----EGLWKQQSELR 3746
Query: 1112 ---GEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
++ + + G E+ + + L ++ +LEA+ ++++ ++ L
Sbjct: 3747 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806
Query: 1169 AQAHGFQGFLRDARQA---------EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMS 1219
QA L + +LS + VL E K+ ++ +
Sbjct: 3807 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3866
Query: 1220 TMDANGERIHGLLEAG--------RQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFL 1271
+D+ E LLE ++V+E N ++ R +D+I ++ ++ A +
Sbjct: 3867 LLDSLNEVSSALLELVPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILR-- 3921
Query: 1272 GRLRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAA 1328
Q F Q WI E K+++ D+ ++ + + Q + F E+
Sbjct: 3922 --------SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3972
Query: 1329 NKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAEL 1387
+KD +D + K G ++ T E K + +KL + + +D T Q + RA+
Sbjct: 3973 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYD---TICQINSERYLQLERAQS 4029
Query: 1388 ----FAQSCCALESWL---ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE 1440
F ++ L WL +S+ +QL + + ++ ++ + L +A + ++
Sbjct: 4030 LVNQFWETYEELWPWLTETQSIISQLPAP--ALEYETLRQQQEEHRQLRELIAEHKPHID 4087
Query: 1441 AIQAQAKALAQEDQGAG-EVERTSRAVEEKFRALCQPMRERCRRL-QASREQHQFHRDVE 1498
+ L + G G ++ A + + + + +++R L +A + QFH D
Sbjct: 4088 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFH-DKI 4146
Query: 1499 DEILWVTERL------PMASSMEHGK------DLPSVQLLMKKNQTLQKEI-QGHEPRIA 1545
D+IL ER+ P + S E K + +V + M+K Q L + + Q E IA
Sbjct: 4147 DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4206
Query: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWM 1604
+ + A A +L ++ +W+ + +E R +L D + A++F+ D +
Sbjct: 4207 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTI 4266
Query: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQ-----LAASSQDMIDHEH 1659
+ + + E + S VK+ Q + + + + + + S+ +
Sbjct: 4267 KDTQDFIRDLEDPGIDPSV---VKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGE 4323
Query: 1660 PESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC-QLRRELDDLEQWIQ-EREVVA 1717
P+ + +++ + L + +R ++L+E ++ Q + L + W+ +A
Sbjct: 4324 PDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA 4383
Query: 1718 ASHELGQDYEHVTMLRDKFREFSRDT--STIGQERVDSANALANGLIAGGHAARATVAEW 1775
+ +G D E V ++ ++F + I ER++ L + + + TV +
Sbjct: 4384 SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE-ESDKHTVQDP 4442
Query: 1776 KDSLNEAWADLLELLDTRGQVLAAAY-ELQRFLHGARQALARVQHKQQQLPDG--TGRDL 1832
L W L E + R L A L +F H + LA + H + L + G D
Sbjct: 4443 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4502
Query: 1833 NAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
A E +H ++D+ A V+ V G+ L ++ AG++A + ++ + + W +
Sbjct: 4503 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4562
Query: 1893 QGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
+ R+Q L + + F + +L W+ + + A + + K Q
Sbjct: 4563 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS---KPLGGLPETAKEQLN 4619
Query: 1952 IKAEI----EARADRFSSCIDMGKELLARSHYAAE-EISEKLSQLQARRQETAEKWQEKM 2006
+ E+ EA+ + + S + G+++LAR +AE I + ++ L+ + + K E+
Sbjct: 4620 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4679
Query: 2007 DWLQLVLEV-LVFGRDAGMAEAWLCSQEPLVRSAEL-GCTVDEVESLIKRHEAFQKSAVA 2064
L+ L + + F WL E + A +D V I H+ F +
Sbjct: 4680 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4739
Query: 2065 WEERFCALEK 2074
E+ L+K
Sbjct: 4740 HREQIIELDK 4749
Score = 68.9 bits (167), Expect = 6e-11
Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 16/282 (5%)
Query: 535 KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASA 594
K QDLL +W++EM+ +L + G L VE L+ H+ V I ++ S
Sbjct: 784 KFVQDLL---NWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 840
Query: 595 LRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAE 654
++ P K +E++ +LE Y L + + L+ L F+
Sbjct: 841 IQMTAPLK-------LTYAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNEL 890
Query: 655 AWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG 714
W+ E++ + D T R + H L E+ + +K E +QL+ E HP
Sbjct: 891 IWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 950
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAW---LVDALRLVS 771
A A +Q QW + L + Q + + + ++F DA + + L DA++
Sbjct: 951 RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKY 1010
Query: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL 813
S + + L ++ +EE+ ++ T+ L +A +
Sbjct: 1011 SCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 1052
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/266 (18%), Positives = 109/266 (40%), Gaps = 24/266 (9%)
Query: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPES 1662
W+ E ++ + E D S ++ ++ H+ + +A+ ++ ++ + S M P
Sbjct: 792 WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLK 848
Query: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLEQWIQEREVVAASHE 1721
+ + +++ YA L + + L H + + EL W+ E+E +++
Sbjct: 849 LTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELI----WLNEKEEEEVAYD 904
Query: 1722 LGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNE 1781
+ ++ +D E R+ +E + S +A L+ H AR T+ ++ ++
Sbjct: 905 WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 963
Query: 1782 AWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRR 1841
W+ +L+L Q + F + A++A ++ N +A+QR+
Sbjct: 964 QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR--------------NLKDAIQRK 1009
Query: 1842 H-CAYEHDIQALSPQVQQVQDDGHRL 1866
+ C I L VQ+ ++ L
Sbjct: 1010 YSCDRSSSIHKLEDLVQESMEEKEEL 1035
Score = 45.8 bits (107), Expect = 5e-04
Identities = 52/280 (18%), Positives = 110/280 (39%), Gaps = 28/280 (10%)
Query: 296 VLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSF-NSYRTVE 354
+LD + E + K+ +LL W+++ V L+ + + L V++ L++ N +R +E
Sbjct: 771 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 827
Query: 355 KPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALR 414
+ ++ + + T KL Y E+L + E + L
Sbjct: 828 EFESSLKEAKISEIQMTAPLKL------TYA--------------EKLHRLESQYAKLLN 867
Query: 415 TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDI 474
T ++ L+ L F +A WL+E + ++ + H + ++
Sbjct: 868 TSRNQERHLDTLH-NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 926
Query: 475 VAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534
+++V +A +L E + I A + + W ++ Q+ + + N
Sbjct: 927 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 986
Query: 535 KVFQDLLYLMDWMEEMKGRLQ---SQDLGRHLAGVEDLLQ 571
+ F D D++ +K +Q S D + +EDL+Q
Sbjct: 987 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ 1026
Score = 45.8 bits (107), Expect = 5e-04
Identities = 205/1138 (18%), Positives = 417/1138 (36%), Gaps = 193/1138 (16%)
Query: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064
+++LE + +G +T + + A + R E+ +++ + +
Sbjct: 1291 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLR-SELNVVLQNMNQVYSMSSTYIDKL 1349
Query: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSR 1123
+ + L++ +A + +T + EE A E L++ R EV+ + +
Sbjct: 1350 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF-- 1407
Query: 1124 LRALGEEVTRDQADPQCLFLRQRLEALGTGW-----EELGRMWESRQGRLAQAHGFQGFL 1178
AL +E+ + +A +F + L W ++L W++ ++
Sbjct: 1408 -HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR------- 1459
Query: 1179 RDARQAEGVLSSQEYVL-SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQ 1237
R EG+ S +Y ++ + +Q + +K+++ N + + L +
Sbjct: 1460 --LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQE---NQPENSKTLATQLNQQKM 1514
Query: 1238 LVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ---HFLQDCHELKLWI 1294
LVSE + K+ E Q A+Q+ ++D Q + D +
Sbjct: 1515 LVSEIEMKQSKMDEC-----------QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1563
Query: 1295 DEKMLTAQDVSYDEARNLHTKWQKHQAFMAE-LAANKDWLDKVDKEGRELTLEKPELKAL 1353
+M ++ D+ E +L T++ M + + D L ++++E + L EK E
Sbjct: 1564 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHV-- 1621
Query: 1354 VSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK 1413
EK ++L + + T L DA +A S + + S + + +
Sbjct: 1622 --EKAKELQKWVSNISKT-------LKDAEKAGKPPFS----KQKISSEEISTKKEQLSE 1668
Query: 1414 DLTSVNILLKKQ--QMLEWEMAVREKEVEAIQAQAKAL-------AQEDQGAGEVERTSR 1464
L ++ + L K +M + E EK+V+ +Q L QE Q +G+V+ +
Sbjct: 1669 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK 1728
Query: 1465 AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQ 1524
V E+ + + ++ C L + + H++ + G ++
Sbjct: 1729 IVAERQQEYKEKLQGICDLLTQTENRLIGHQE----------------AFMIGDGTVELK 1772
Query: 1525 LLMKKNQTLQKEIQGHEPRIAD--------LRERQRALG---AAAAGPELAELQEMWKRL 1573
K + LQK++QG +A+ L+E L A +L E + ++L
Sbjct: 1773 KYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1832
Query: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL------SAQAEV 1627
+ E K L+ + ++ E A + + E E D L S +A
Sbjct: 1833 NLKAEQSKKELDKVVTTA--IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1890
Query: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPEST---RISIRQAQVDKLYAGLKE--- 1681
K QV+EQ + + + A +D ++ E+ ++ Q +++ Y +K
Sbjct: 1891 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1950
Query: 1682 --------------------------LAGERRERLQEHLRLCQ----------------- 1698
L+ E +E+LQ++++ +
Sbjct: 1951 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 2010
Query: 1699 --LRRELD-------DLEQWIQEREVVAASHELGQDYEHVTMLR-DKFREFSRDT----- 1743
L+ EL+ + E W+Q+ E + E G D + M + + + FS D
Sbjct: 2011 HSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG 2070
Query: 1744 ----STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLA- 1798
TI RV A + G AT E + L+ A D L ++ VL
Sbjct: 2071 DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA-TDRFRSLYSKCNVLGN 2129
Query: 1799 ----AAYELQRFLHGARQALARVQ--------HKQQQL---PDGTGRDLNAAEALQRRHC 1843
+ Q + + LA +Q H + + P R L +ALQ +
Sbjct: 2130 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2189
Query: 1844 AYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQ-L 1902
+ + ++ L + + D L A +I + + + + L S R + L
Sbjct: 2190 SQQVAVEKLKKTAEVLLDARGSLLPA-----KNDIQKTLDDIVGRYEDLSKSVNERNEKL 2244
Query: 1903 LLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ-ERPRDVSSADLVIKNQQGIKAEIEARAD 1961
+ T + E++ WM V + Q + P + ++ +I ++ +I R
Sbjct: 2245 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2304
Query: 1962 RFSSCIDMGKELLARSH-YAAEEISEKLSQLQARRQETAEKWQE---KMDWLQLVLEV 2015
++ + K+ + + A + K+ L AR E + K +E KM+ L+ +E+
Sbjct: 2305 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL 2362
Score = 43.1 bits (100), Expect = 0.003
Identities = 62/299 (20%), Positives = 118/299 (39%), Gaps = 36/299 (12%)
Query: 1378 SLFDANRAE-----LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML---- 1428
SL D N E F Q L +W++ +Q QL ++G DL SV L+ + +
Sbjct: 770 SLLDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 826
Query: 1429 -EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQAS 1487
E+E +++E ++ IQ A E+ R +E ++ L R + R L
Sbjct: 827 EEFESSLKEAKISEIQMTAPLKLT------YAEKLHR-LESQYAKLLNTSRNQERHLDT- 878
Query: 1488 REQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL 1547
H F +E++W+ E+ + + + ++ + L +E+ E I +
Sbjct: 879 --LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSV 936
Query: 1548 RERQRALGAAAAGPEL------AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
+E L L A +Q W + + + +++ +F+ DA EA
Sbjct: 937 QEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 996
Query: 1602 AWMGEQELHMMGQEKAKDELSAQAE-----VKKHQVLEQALADYAQTIHQLAASSQDMI 1655
++ + L Q K + S+ V++ ++ L Y TI L ++ +I
Sbjct: 997 DYL--RNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 1053
Score = 40.8 bits (94), Expect = 0.016
Identities = 37/205 (18%), Positives = 84/205 (40%), Gaps = 16/205 (7%)
Query: 1497 VEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGA 1556
V+D + WV E E G DLPSV+ ++ ++ + + I+ E + + + + +
Sbjct: 786 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM-- 843
Query: 1557 AAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRD--------AAEAEAWMGEQE 1608
A L+ + H LE + +L + R Q+ + D A W+ E+E
Sbjct: 844 ------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKE 897
Query: 1609 LHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIR 1668
+ + ++ + + H L + L + I + ++ ++ HP I
Sbjct: 898 EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 957
Query: 1669 QAQVDKLYAGLKELAGERRERLQEH 1693
+A + ++ + +L + ++E+
Sbjct: 958 RAAMQTQWSWILQLCQCVEQHIKEN 982
Score = 40.4 bits (93), Expect = 0.021
Identities = 44/225 (19%), Positives = 86/225 (38%), Gaps = 5/225 (2%)
Query: 758 DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTL 817
D+ W+ + + E G D S ++ H+ + I +L + + L
Sbjct: 788 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPL 847
Query: 818 SRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNG 877
T ++ LE Y +L + + R L+ L+ +S A +W+ EKE+
Sbjct: 848 KLT--YAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVA 902
Query: 878 LALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLN 937
ER ++ + L E++ I +V +IAEQLL N P + I + +
Sbjct: 903 YDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQ 962
Query: 938 HRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIE 982
+W +L + + + + + E ++R I+
Sbjct: 963 TQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 1007
Score = 33.5 bits (75), Expect = 2.6
Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 8/100 (8%)
Query: 1914 KAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGK-- 1971
K V++L+ W+DE+ +Q+D E D+ S + ++N + + IE F S + K
Sbjct: 784 KFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE----EFESSLKEAKIS 839
Query: 1972 --ELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++ A E +L A+ T+ + +D L
Sbjct: 840 EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL 879
Score = 32.0 bits (71), Expect = 7.5
Identities = 105/572 (18%), Positives = 223/572 (38%), Gaps = 70/572 (12%)
Query: 1565 ELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE-AEAWMGE--------QELHMMGQE 1615
+L E W+ + +++ R + LE ++ ++YRD + W+ + QE +
Sbjct: 1444 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 1503
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQT-IHQLAASSQD----------MIDHEHPESTR 1664
+L+ Q + ++Q+ D Q Q +A+ +D M+D + +
Sbjct: 1504 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1563
Query: 1665 ISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQ 1724
Q+ D + +L R L ++ D L++ +E + + +
Sbjct: 1564 RRRMQSSADLIIQEFMDL--RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK--- 1618
Query: 1725 DYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWA 1784
EHV +K +E + S I + D+ A + + ++ K+ L+EA
Sbjct: 1619 --EHV----EKAKELQKWVSNISKTLKDAEKA-GKPPFSKQKISSEEISTKKEQLSEALQ 1671
Query: 1785 DLLELLDTRGQVLA--AAYELQRFLHGARQA--LARVQHKQQQLPDGTGRDLNAAEAL-Q 1839
+ L G + EL++ + +++ L + +Q T D+ E +
Sbjct: 1672 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1731
Query: 1840 RRHCAYEHDIQALSPQVQQVQDDGHRLQKAY-AGDKAEEIGRHMQAVAEAWAQLQGSSAA 1898
R Y+ +Q + + Q ++ Q+A+ GD E+ ++ E +QGS+ A
Sbjct: 1732 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1791
Query: 1899 RRQLLLDT-------------TDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLV 1945
+++ +T DK + + E + +++NL+ + ++ D +
Sbjct: 1792 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1851
Query: 1946 IKNQQGIKA--EIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQ 2003
+ + + A ++E + + +D + S A + + + Q QE K
Sbjct: 1852 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1911
Query: 2004 --EKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS 2061
E+ + +LE V G+ G + L Q V++ + E +I +H+A
Sbjct: 1912 IGEEDEVNGNLLETDVDGQ-VGTTQENLNQQYQKVKA--------QHEKIISQHQAV--- 1959
Query: 2062 AVAWEERFCALEK---LTALEEREKERKRKRE 2090
+A + LEK + EE+EK +K +E
Sbjct: 1960 IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1991
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 312 bits (800), Expect = 2e-84
Identities = 181/404 (44%), Positives = 248/404 (61%), Gaps = 15/404 (3%)
Query: 53 DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112
DER+ VQKKTFTKW+N HL +V V DLY DLRDG NL+ LLEVLSG+ LP+ KGRMR
Sbjct: 31 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGRMR 89
Query: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172
H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V E
Sbjct: 90 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGES- 148
Query: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232
E SAK+ LLLW Q T GY + NFTT WRDG FNAI+HK+RPDL+D ++ +
Sbjct: 149 -EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQS 207
Query: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292
NL++AF +AEK +G+ +LLDPEDV+V PDEKS+ITYV++ Y F K+ G+
Sbjct: 208 NLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GGEG 263
Query: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352
IG A + E +Y+++ + L+QWI + T+++R N+ ++ + ++
Sbjct: 264 IG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318
Query: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412
E PPK TEK ++ L ++ + K+ +G +DI K W +L A ERE A
Sbjct: 319 TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKA 375
Query: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLE 456
LR E+ R E L+Q+A R R + + E L + D+ LE
Sbjct: 376 LRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE 419
Score = 159 bits (403), Expect = 2e-38
Identities = 343/1769 (19%), Positives = 687/1769 (38%), Gaps = 166/1769 (9%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTI-VTLNDRQLANSLSGVQNQLQSFNS 349
K++ + EA +++ LL W+ T + N + + V+ Q+Q
Sbjct: 3292 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL 3351
Query: 350 YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHER 409
+ + K T +EV+ + +K+ T E +D K ++L +
Sbjct: 3352 LQRLLDDRKST----VEVI--------KREGEKIATTAEP---ADKVKILKQLSLLDSRW 3396
Query: 410 ELALRTELIRQEKLEQL---AARFDRKAAMRETWLSE-NQRLVSQDNFGLELAAVEAAVR 465
E L R +LE + A +F WL+ +RLV+ + G + + +E +
Sbjct: 3397 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3456
Query: 466 KHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDF-LRQMVAARR 524
+H+A+E DI+ ++ + ++ L + K + + + +++W +++ +R
Sbjct: 3457 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3516
Query: 525 ERLLLNLELQKVF-QDLLYLMDWMEEMKGRLQSQDLGRHLA-GVEDLLQLHELVEADIAV 582
E L L K+F +D + LM+W+ E+ +L + + G+ +++ DI +
Sbjct: 3517 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3576
Query: 583 QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642
+ + V + L K+ + ++ +++ ++ Y+ + +L+ LE++ +
Sbjct: 3577 RKQNVDQALLNGLELL---KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3633
Query: 643 LWRFLWEVGEAEA-WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTL 701
L R L E W+ + + L S +T ++L A + +M R LK
Sbjct: 3634 LARRLHSTHEELCTWLDKVEVELLSYET--------QVLKGEEASQAQM--RPKELKKEA 3683
Query: 702 EQGQQLVAEGHPGASQASARAAELQAQW---ERLEALAEERAQRLA-------------Q 745
+ + L+ ++ S+ EL W E LE + E +R
Sbjct: 3684 KNNKALL----DSLNEVSSALLEL-VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
Query: 746 AASLYQFQAD-ANDME-AWLVDA-LRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPT 802
AA L Q D A D E +W+ + +L+S ++ ++ T A + + EI H+
Sbjct: 3739 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3798
Query: 803 LDALREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSE 860
+D L + + S + ++ ++ + ++Y+ + ER LE A +L E
Sbjct: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858
Query: 861 A-GACGLWVEEKEQWLNGLALPE-RLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918
W+ E + ++ L P E L Q+ L + I +N QL
Sbjct: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918
Query: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN-YHLECTETQAWMREK 977
L+ +P I + + Q + + AL A+S +H + + +
Sbjct: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LESL 3975
Query: 978 TKVIESTQGLGNDLAGVLALQRKLAGTER---DLEAIAARVGELTREANALAA-----GH 1029
+++E + + A V ++ +++ + D+E + L + + A
Sbjct: 3976 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4035
Query: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQD-FLRSLDDFQAWLGRTQTAV 1088
A A+ +L ++ WE++ + RE L + L + F + TQ +
Sbjct: 4036 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4095
Query: 1089 ASEEGPATLPEAEALLAQHA-ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147
E P P + A +R E++ Q E + LG E+ +P +++ +
Sbjct: 4096 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4155
Query: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA--EGVLSSQEYVLSHTEMPGTLQ 1205
+ L + W+ L + W+ R +L +A +D QA + V + + S + + L+
Sbjct: 4156 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4215
Query: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK---------IREKADSI 1256
I++L+ F S + L L+ + +DK ++ DS+
Sbjct: 4216 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4275
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWI--DEKMLTAQDVSYDEARNLHT 1314
E R Q + G L + QH L EL W+ E +L+ Q + + +
Sbjct: 4276 EERIINRQHKLE---GALLALGQFQHALD---ELLAWLTHTEGLLSEQKPVGGDPKAIEI 4329
Query: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP-ELKALVSEKLRDLHRRWDE-LETTT 1372
+ KH ++ A++ ++ V+K G +L E + + KL L++RW LE T
Sbjct: 4330 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4389
Query: 1373 QAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEM 1432
Q K + +A+ F L+ WL + L + K L + K+Q + E+
Sbjct: 4390 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVHMEV 4446
Query: 1433 AVREKEVEAIQAQAKALAQEDQ---------GAGEVERTSRAVEEKFRALCQPMRERCRR 1483
EA + K+L Q+ Q +++ ++EK+ ++ + ER +
Sbjct: 4447 CA---AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4503
Query: 1484 L-QASREQHQFHRDVEDEILWVTE-RLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHE 1541
L +A +FH ++D I W+T+ + + L +V + +++ E+ H
Sbjct: 4504 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4563
Query: 1542 PRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDA-LRAQQF 1593
+I +L + L + + L +Q W+++ L RG+ L+DA RA+QF
Sbjct: 4564 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4623
Query: 1594 YRDAAEAEAWMGEQELHMMGQ-EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQ 1652
+ ++ W+ E E + + E A D + ++ +H+ +++L + +
Sbjct: 4624 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4683
Query: 1653 DMIDHEHPESTRISIRQAQVDKLYAGLKE----LAG---ERRERLQEHLRLC-QLRRELD 1704
+ E T ++ ++D + + L++ + G ER+ +L+E L Q L
Sbjct: 4684 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQ 4738
Query: 1705 DLEQWIQERE-VVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL---ANG 1760
L W+ E +A + D + V L D + F ++ +R S AL A
Sbjct: 4739 ALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELG----KRTSSVQALKRSARE 4794
Query: 1761 LIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHK 1820
LI G + V L+ W + L ++ L AA H AL +
Sbjct: 4795 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE 4854
Query: 1821 QQQ-------LPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
+Q LPD D +A L +H + ++ ++ + G + D
Sbjct: 4855 AEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4910
Query: 1874 KAEEIGRHMQAVAE------AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927
I + + AWA+ A L K +A+ + W +
Sbjct: 4911 SITTIKHWITIIRARFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTL 4968
Query: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEI 1956
D + P+++ +I Q E+
Sbjct: 4969 TDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
Score = 129 bits (325), Expect = 3e-29
Identities = 339/1876 (18%), Positives = 719/1876 (38%), Gaps = 160/1876 (8%)
Query: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLN---DRQLANSLSGVQNQL--Q 345
K+ K+LD A E VE E +++ + L + + + G++ + Q
Sbjct: 3174 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3233
Query: 346 SFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKA 405
N ++ +K +G + + + Q +++ + T + D+N W+ L K
Sbjct: 3234 QLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK 3293
Query: 406 EHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV-SQDNFGLELAAVEAAV 464
+R L+ L+ RF +W+ + + LV +Q E V+A +
Sbjct: 3294 VAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQI 3346
Query: 465 RKHEAIETDIVAYSGRVQAVDAVAAELA--AERYHDIKRIAARQHNVARLWDFLRQMVAA 522
++ + ++ + V+ + ++A AE +K I + + W+ L
Sbjct: 3347 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSRWEALLNKAET 3405
Query: 523 RRERLL-LNLELQKVFQDLLYLMDWMEEMKGRL-QSQDLGRHLAGVEDLLQLHELVEADI 580
R +L +++ Q+ + L L +W+ ++ RL + +G + +E+ + H+ +E DI
Sbjct: 3406 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3465
Query: 581 AVQAERV-RAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEE 639
+ + +AVS +E D +V ++ + Y + E + +R L++
Sbjct: 3466 INHNKHLHQAVSIGQSLKVLSSRE----DKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3521
Query: 640 SRRLWRFLWE-VGEAEAWVREQQHLLASADTGRDLT-------GALRLLNKHTALRGE-- 689
+ + E E W+ E L+ T LR+L + LR +
Sbjct: 3522 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3581
Query: 690 ---MSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
+ L LK T ++ + + ++A+++ + L+ + A+ L QA
Sbjct: 3582 DQALLNGLELLKQTTGDEVLIIQD----------KLEAIKARYKDITKLSTDVAKTLEQA 3631
Query: 747 ASL-YQFQADANDMEAWL--VDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803
L + + ++ WL V+ L ++ E ++QA R + L++E ++++ L
Sbjct: 3632 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNNKALL 3690
Query: 804 DALREQAAALPPTLS-RTPE-VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861
D+L E ++AL + R E ++ V Y + ++ ++AA+ +A
Sbjct: 3691 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3750
Query: 862 GACGL-WVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK 920
L W+ E E+ L L D+ + Q + T +I DI + L+K
Sbjct: 3751 ADAELSWITETEKKLMSLG------DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3804
Query: 921 A--------NPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC-TETQ 971
+ + K + +++ + ++ + L A S+ N E E
Sbjct: 3805 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3864
Query: 972 AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
W+ E +I + + Q + + + ++ + L P
Sbjct: 3865 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEA-RRLQDFLRSLDDFQAWLGRTQTAVAS 1090
+ +I + T + ++ +++R +L EA + F +D L R +
Sbjct: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL-- 3982
Query: 1091 EEGPATLPEAEAL---LAQHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFL 1143
+ P+ E E + ++++ + ++E+ Q Y L+ GEE+ D +
Sbjct: 3983 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
Query: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGF-QGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
+ +L+ + WE + + E R+ +L + F D + + + E PG
Sbjct: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102
Query: 1203 -----TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSE-GNIHADKIREKADSI 1256
Q +AA E +D E + ++ G +L++ G +++ D +
Sbjct: 4103 IDPSVVKQQQEAA----ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4158
Query: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKL-WID---EKMLTAQDVSYDEARNL 1312
A + + +L + + QD + W+D K+ + + D +
Sbjct: 4159 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD-LETV 4217
Query: 1313 HTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK---PELKALVSEKLRDLHRRWDELE 1369
+ ++ + F +E + +++++ + EL L+K K V + L +L WD LE
Sbjct: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4276
Query: 1370 TTTQAKARSLFDANRA-ELFAQSCCALESWLESLQAQL-HSDDYGKDLTSVNILLKKQQM 1427
+ L A A F + L +WL + L G D ++ I L K +
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4336
Query: 1428 LEWEMAVREKEVEAIQAQAKALAQEDQG--AGEVERTSRAVEEKFRALCQPMRERCRRLQ 1485
L+ ++ + VEA+ L + G A ++ + ++++ + + +R ++L
Sbjct: 4337 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4396
Query: 1486 -ASREQHQFHRDVEDEILWVTE-------RLPMASSMEHGKDLPSVQL-----LMKKNQT 1532
A R+ FH ++ED W+T+ P+ E K+ +V + K +T
Sbjct: 4397 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4456
Query: 1533 LQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQ 1591
+ +Q + +A R ++ L+E W+ + +L R +LE+AL A
Sbjct: 4457 YKSLMQKGQQMLA----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
Query: 1592 QFYRDAAEAEAWM--GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAA 1649
+F+ + W+ EQ L++ + + + ++ +H+V + + + I +L
Sbjct: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILD-TVLFQIDEHKVFANEVNSHREQIIELDK 4571
Query: 1650 SSQDM-IDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLE 1707
+ + + + I V + + + ER L + R Q L
Sbjct: 4572 TGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4631
Query: 1708 QWIQEREVVAASH-ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGH 1766
+W++E E S E+ D + + + +EF + D+ N L
Sbjct: 4632 EWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA-KHSVYDTTNRTGRSL----- 4685
Query: 1767 AARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPD 1826
+ ++A+ L++ ++L + DT + + E Q L A + Q L D
Sbjct: 4686 KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDALQALID 4742
Query: 1827 GTGR-------------DLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
R D++ L H A++ ++ + VQ ++ L + + D
Sbjct: 4743 WLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRD 4801
Query: 1874 KAEEIGRHMQAVAEAW---AQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQM 1930
+ + MQ ++ W L S R + L ++F V L+ W+ E +
Sbjct: 4802 DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFH--SVVHALLEWLAEAEQTL 4859
Query: 1931 DAQ-ERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSH-YAAEEISEKL 1988
P D + +I + ++E + + MG +LA H + I +
Sbjct: 4860 RFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWI 4919
Query: 1989 SQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMA-EAWLCSQEPLVRSAE---LGCT 2044
+ ++AR +E ++ L L L+ ++ A AWL E + + +
Sbjct: 4920 TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE 4979
Query: 2045 VDEVESLIKRHEAFQK 2060
++EV++LI H+ F +
Sbjct: 4980 IEEVKALIAEHQTFME 4995
Score = 118 bits (296), Expect = 6e-26
Identities = 206/1008 (20%), Positives = 403/1008 (39%), Gaps = 91/1008 (9%)
Query: 399 WERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-DNFGLEL 457
WE + ERE L + +LA +F + + Q + ++ G++
Sbjct: 4053 WENIHTLVEEREAKLLDVM-------ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4105
Query: 458 AAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQ-HNVARLWDFL 516
+ V+ E I +I + V + +EL A K I + + WD L
Sbjct: 4106 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4165
Query: 517 RQMVAARRERLLLNLELQKVFQD-LLYLMDWMEEMKGRLQSQD-LGRHLAGVEDLLQLHE 574
+ R ++L ++ +QD L + DW++ G+L S +G L V+ ++ +
Sbjct: 4166 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4225
Query: 575 LVEADI---AVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
+++ ++ ER+ + L+ K D V + + +L+ +++L E
Sbjct: 4226 QFKSEAYQQQIEMERLNHQAELLLK-----KVTEESDKHTVQDPLMELKLIWDSLEERII 4280
Query: 632 ARRARLEESR-RLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTALRGE 689
R+ +LE + L +F + E AW+ + LL+ G D L KH L+ +
Sbjct: 4281 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4340
Query: 690 MSGRLGPLKLTLEQGQQLVAEGHPG--ASQASARAAELQAQWERLEALAEERAQRLAQAA 747
+ ++ + G L+ E G AS + L +W+ + E+R Q+L A
Sbjct: 4341 VLAHQSTVEAVNKAGNDLI-ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4399
Query: 748 SLYQ-FQADANDMEAWLVDALR-LVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDA 805
+ F + D++ WL D R L++S LG + + H + + T +
Sbjct: 4400 RQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS 4459
Query: 806 LREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGA 863
L ++ + ++ E + + L+ +E ++ + ER LE AL L +
Sbjct: 4460 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQ 4519
Query: 864 CGL-WVEEKEQWLNGLALPERLEDLEVVQ-QRFETLEPEMNTLAAQITAVNDIAEQLLKA 921
+ W+ + EQ LN + P + D + Q + E+N+ QI ++ L K
Sbjct: 4520 DFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL-KY 4578
Query: 922 NPPGKDRIV--NTQEQLNHRWQQF-RRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978
+D ++ N + RW++ +RL + ++ + + +H ++ W+ E
Sbjct: 4579 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4638
Query: 979 KVIESTQGLGND-------LAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
K ++S + ND LA Q+ L G + + R G +E +LA +
Sbjct: 4639 KSLDSELEIANDPDKIKTQLAQHKEFQKSL-GAKHSVYDTTNRTGRSLKEKTSLADDN-- 4695
Query: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEAR----RLQDFLRSLDDFQAWLGRTQTA 1087
+ ++ L E++ W+ + R+ L EA + D L++L D WL R +
Sbjct: 4696 --LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID---WLYRVEPQ 4750
Query: 1088 VASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQR 1146
+A ++ + L+ H A + E+ + S L+ E+ D +++ +
Sbjct: 4751 LAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WVKVQ 4809
Query: 1147 LEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL--------SSQEYVLSHT 1198
++ L T WE + + S+Q RL A LR A + V+ +++ + H
Sbjct: 4810 MQELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEAEQTLRFHG 4863
Query: 1199 EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKI--------- 1249
+P A I + ++FM ++ ++ G +++ H D I
Sbjct: 4864 VLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI--CHPDSITTIKHWITI 4921
Query: 1250 -REKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWID--EKMLTAQD--V 1304
R + + + K++Q Q+ L +Q L+ L W+ E LT +D V
Sbjct: 4922 IRARFEEVLAWAKQHQ---QRLASALAGLIAKQELLE---ALLAWLQWAETTLTDKDKEV 4975
Query: 1305 SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
E + +HQ FM E+ + +DKV K + + L++
Sbjct: 4976 IPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5023
Score = 110 bits (275), Expect = 2e-23
Identities = 361/1905 (18%), Positives = 719/1905 (37%), Gaps = 278/1905 (14%)
Query: 362 KGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQE 421
K EVLL S L A N T + DI +E L K+ +ER L+ L R
Sbjct: 2021 KKTAEVLLDARGSLLPAKNDIQKT------LDDIVGRYEDLSKSVNERNEKLQITLTRSL 2074
Query: 422 KLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRV 481
++ D M + + L Q L A++ + K+ +E DI +
Sbjct: 2075 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2128
Query: 482 QAVDAVAAEL--------AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLEL 533
A++ + A+ +K ++AR + + A+ E L +EL
Sbjct: 2129 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK----HKETLAKMEELKTKVEL 2184
Query: 534 QKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSAS 593
F++L + E K +Q L +D+ +L + ++ + E + +
Sbjct: 2185 ---FENLSEKLQTFLETK----TQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVL 2237
Query: 594 ALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESR-RLWRFLWEVGE 652
P D LV E+ L + ++ + + ++ + + +L F V
Sbjct: 2238 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
Query: 653 AEAWVREQ-------QHLLASADTGRDLTGALRLLNKHTALRGEM--------------S 691
++W++E Q + D G+ L +L K + E+ S
Sbjct: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
Query: 692 GRLGPLKLTL---EQGQQLVAEG----------HPGASQASARAAELQAQWERLEALAEE 738
P K G L EG + G + ++ +E L L ++
Sbjct: 2358 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2417
Query: 739 RAQRL-AQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL---ARQHRALEE 794
+ L + + L + Q +++ M WL + + + T+A+ Q+++ E
Sbjct: 2418 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA 2477
Query: 795 EIRSHRPTLDALREQAAALPPTLSRTPEV---QGRVPTLERHYEELQARAGERARALEAA 851
E++ + + L+++ L TPE + + ++ ++EL +R + LE +
Sbjct: 2478 ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES 2537
Query: 852 LALYTMLSEAGA-CGLWVEEKEQWLNGLA--------LPERLEDLEVVQQRFETLEPEMN 902
T A W+ EKE ++ L L + + ++++ Q F T +P+
Sbjct: 2538 SNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE 2597
Query: 903 TLAAQITAVNDIAEQLLKANPPGKDRIVN--TQEQLNHRWQQFRRLADGKKAALTSALS- 959
L A + + PG+D + +EQL Q++ +LT LS
Sbjct: 2598 QLTAAGQGI---------LSRPGEDPSLRGIVKEQLAAVTQKWD--------SLTGQLSD 2640
Query: 960 ----IQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARV 1015
I ++ T+ Q+ +R + + L N L+ LA+ + LE
Sbjct: 2641 RCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK 2697
Query: 1016 GELTREANALAAGHPAQAVA--INARLREVQTGWEDLRATMRRREESL------------ 1061
E+ +E + AQA+ ++A ++E E L+A + R+ E +
Sbjct: 2698 QEIQQEKKQIKV---AQALCEDLSALVKE-----EYLKAELSRQLEGILKSFKDVEQKAE 2749
Query: 1062 GEARRLQD-------FLRSLDDFQAWLGRTQTAVASEEGP--ATLPEAEALLAQHAALRG 1112
+ LQ F + DFQAWL T+ ++ P A L E+L+ H
Sbjct: 2750 NHVQHLQSACASSHQFQQMSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2808
Query: 1113 EVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAH 1172
+ Y + A GE + + L+ +L + T W+ + + R+ +L ++
Sbjct: 2809 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES- 2867
Query: 1173 GFQGFLRDARQAEGV----------LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMD 1222
+ L+ Q E + L ++ L E ++ + K+++ ++
Sbjct: 2868 -LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 2926
Query: 1223 ANGERIHGLL---EAGRQLVSEGNIHADKIREKADSI-ERRHKKN---QDAAQQFLGRLR 1275
+ LL E +++V++ N + +K D + E+ H K ++ Q+F
Sbjct: 2927 LLNNTANSLLSVCEIDKEVVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE 2983
Query: 1276 DNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQ-----KHQAFMAELAANK 1330
++E + LQ C + +L I + L +Q S L T+ + KHQ +A+ A
Sbjct: 2984 VSKESKRQLQ-CAKEQLDIHDS-LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3041
Query: 1331 DWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDE----LETTTQA------KARSLF 1380
++ D +G L + E ++++ L ++ DE LET Q R +F
Sbjct: 3042 LVVEASDSKGTSDVLLQVE---TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMF 3098
Query: 1381 D---------------ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQ 1425
AE + ++++L+ L+A + S+D + + ++
Sbjct: 3099 SQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 3158
Query: 1426 QMLEWEMAVREKEVEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRL 1484
++ ++++EA+ Q L Q E VE T + +EE + L +E L
Sbjct: 3159 SP---DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL----KEFSILL 3211
Query: 1485 QASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRI 1544
Q + E + V E + ++L M + ++ L K Q + QG
Sbjct: 3212 QKAEEHEESQGPVGMETETINQQLNMFKVFQK----EEIEPLQGKQQDVNWLGQGL---- 3263
Query: 1545 ADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAW 1603
++ ++ +L ++ WK L ++ R +L++AL ++DA E+ +W
Sbjct: 3264 --IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3321
Query: 1604 MGEQELHMMGQEKAKDELS-AQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-E 1661
M + E + Q+ E +A++++ ++L++ L D T+ + + + P +
Sbjct: 3322 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
Query: 1662 STRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC--QLRRELDDLEQWIQ--EREVVA 1717
+I + + +D + L A E R R E + + Q L+ L +W+ E+ +V
Sbjct: 3382 KVKILKQLSLLDSRWEALLNKA-ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLV- 3439
Query: 1718 ASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKD 1777
+ E + K E + + ++ L + G + E KD
Sbjct: 3440 -------NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3492
Query: 1778 ------SLNEAW-ADLLELLDTRGQVLAAA-----------YELQRFLHGARQALARVQH 1819
++ W ++ E +R ++L A EL +L+ L+++
Sbjct: 3493 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS- 3551
Query: 1820 KQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879
Q +G + + LQ DI V Q +G L K GD+ I
Sbjct: 3552 VQDYSTEGLWKQQSELRVLQ-------EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3604
Query: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAV-RELMLWMDEVNLQMDAQE---- 1934
++A+ + + S + L R + EL W+D+V +++ + E
Sbjct: 3605 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVL 3664
Query: 1935 RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQAR 1994
+ + S A + K +K E + S ++ LL + A E EK+
Sbjct: 3665 KGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE 3721
Query: 1995 R----QETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLC-SQEPLVRSAELGCTVDEVE 2049
R +T + E++D +L F + A +W+ +++ L+ ++ D+
Sbjct: 3722 RYRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3779
Query: 2050 SLIKRHEAFQKSAVAWEERFCALEK-----LTALEEREKERKRKR 2089
+ ++ + F + ++ L K +TA E EK+ +K+
Sbjct: 3780 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3824
Score = 108 bits (269), Expect = 8e-23
Identities = 343/1970 (17%), Positives = 756/1970 (38%), Gaps = 251/1970 (12%)
Query: 252 KLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGK--VLDHAMEAERLVEK 309
K L+ E+ ++++ ++K + + S + + ++ GK + +E + K
Sbjct: 1426 KRLEEEEKSLEE-EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1484
Query: 310 YESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFN-SYR-----TVEKPPKFTEKG 363
E L SE LQ I+ + D+ + ++ Q+++ SY ++++ + G
Sbjct: 1485 KEQL-SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1543
Query: 364 NLEVLLFTIQSKLRANNQKVY-----------TPREGRLISD-----INKAWERLEKAEH 407
+++V + K+ A Q+ Y T E RLI I L+K +
Sbjct: 1544 DVKV-----EEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1598
Query: 408 ERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467
++E EL Q+ ++ A E +L EN +SQ++ L + A K
Sbjct: 1599 KQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1651
Query: 468 EAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL------RQMVA 521
E + + V A + E+ +K++ + + L D+L +
Sbjct: 1652 EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1711
Query: 522 ARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDL-GRHLAGVEDLLQLHELVEAD- 579
+ ++++ D + +E+ G L D+ G+ E+L Q ++ V+A
Sbjct: 1712 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1771
Query: 580 ---IAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYE-ALCELAAARRA 635
I+ + A ++ + G+ P + + + + + +L+ YE AL E +
Sbjct: 1772 EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL 1831
Query: 636 RLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR-DLTGALRLLNKHTALRGEMSGRL 694
L +F + E E W+++ + L + + G D+ G + L + + ++
Sbjct: 1832 THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK 1891
Query: 695 GPLKLTLEQGQQLV------AEGHPGASQASARAAELQA-------QWERLEALAEERAQ 741
G L+ G +++ ++ G SA E+Q ++ L +
Sbjct: 1892 GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN 1951
Query: 742 RLAQAASLYQFQADAN-----DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
L YQ DA+ ++A A + +S P + D + Q + +AL+ +I
Sbjct: 1952 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP-IAVDPKNLQRQLEETKALQGQI 2010
Query: 797 RSHRPTLDALREQAAAL----PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAAL 852
S + ++ L++ A L L ++Q + + YE+L ER L+ L
Sbjct: 2011 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2070
Query: 853 ALYTMLSEAGACGLWVEEKEQWLNGL--------ALPERLEDLEVVQQRFETLEPEMNTL 904
+ + ++E W+ + +P L+ + + LE ++
Sbjct: 2071 TRSLSVQDG------LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2124
Query: 905 AAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS----ALSI 960
+ I A+N+ ++ ++ P + Q ++ +F + K L +
Sbjct: 2125 QSSINAMNEKVKKFMETTDP--STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2182
Query: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT----ERDLEAIAARVG 1016
+ + + Q ++ KT+ + G D+ + ++ ++ LE + + +
Sbjct: 2183 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2242
Query: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLD 1075
E++ + G P+ + + + ++++ T++ ++E++ + +L F +
Sbjct: 2243 EIS------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVK 2296
Query: 1076 DFQAWLGRT-------QTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128
++W+ T Q + +E+ +L + + L + + E+++ + L L
Sbjct: 2297 SLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLI 2356
Query: 1129 EEVTRDQ--------------------------ADPQCLFLRQRLEALGTGWEELGRMWE 1162
VT A+ +++ + + G+E+LG + +
Sbjct: 2357 SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK 2416
Query: 1163 SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-------HTEMPGTLQAADAAIKKLE 1215
++A+ + L+ A++ + ++ T P +A +++ +
Sbjct: 2417 D---KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2473
Query: 1216 DFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLR 1275
F + + N ++ L + +L+ E + R K + K Q+ Q + R +
Sbjct: 2474 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK-QMLTEIDSKWQELNQLTIDRQQ 2532
Query: 1276 DNREQQHFLQDCH----ELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAAN 1329
E + L +LK W+ EK M++ + L+T+ Q+ Q + E A
Sbjct: 2533 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATR 2592
Query: 1330 KDWLDKVDKEGRELTL---EKPELKALVSEKLRDLHRRWDEL--------ETTTQAKARS 1378
K +++ G+ + E P L+ +V E+L + ++WD L + QA +S
Sbjct: 2593 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2652
Query: 1379 LFDANRAELFAQSCCALESWL-ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
+ + L++ L SL H D ++N L+ Q ++ E+ +K
Sbjct: 2653 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD-------AMNQQLETAQKMKQEIQQEKK 2705
Query: 1438 EVEAIQA---QAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ-ASREQHQF 1493
+++ QA AL +E+ E+ R + + F+ + Q + LQ A HQF
Sbjct: 2706 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2765
Query: 1494 HRDVEDEILWV-TERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI--QGH--EPRIAD-- 1546
+ D W+ T++ S L ++ L+K ++ K + Q H E IA+
Sbjct: 2766 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
Query: 1547 -LRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAWM 1604
L + + AA +L ++ W +++ R +L+++L Y++ E W+
Sbjct: 2826 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2885
Query: 1605 GEQELHM----------MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDM 1654
+ + ++ G+ S Q E+ +H + + L + A ++ + +++
Sbjct: 2886 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2945
Query: 1655 IDHEHP---ESTRISIRQAQVDKL-YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
+ E+ + + Q K + + E +E +E R Q +E D+ +
Sbjct: 2946 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3005
Query: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
+ +++TML+ + + + +VD A LA L+ ++
Sbjct: 3006 GSQ---------AYSNKYLTMLQTQQKSLQ-----ALKHQVDLAKRLAQDLVVEASDSKG 3051
Query: 1771 T--VAEWKDSLNEAWADLLELLDTRGQVLAAAYE-LQRFLHGARQALARVQHKQQQLPD- 1826
T V +++ + + L + +D + L + + F + R+ ++ +L
Sbjct: 3052 TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSM 3111
Query: 1827 -GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEE-------- 1877
GRD AE LQ++ + I+A +++ + K A E
Sbjct: 3112 APVGRD---AETLQKQ----KETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVG 3164
Query: 1878 IGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF-RFFKAVRELMLWMDEVNLQMDAQERP 1936
I R ++A+++ +L + AR + + T + F+ ++E + + + + +E
Sbjct: 3165 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE---EHEESQ 3221
Query: 1937 RDVSSADLVIKNQQGI-----KAEIEARADRFSSCIDMGKELL--ARSHYAAEEISEKLS 1989
V I Q + K EIE + +G+ L+ A + + + L
Sbjct: 3222 GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD 3281
Query: 1990 QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAE---AWLCSQEPLV 2036
+ AR + +K ++ LQ L L GR E +W+ E LV
Sbjct: 3282 DVNARWKTLNKKVAQRAAQLQEAL--LHCGRFQDALESLLSWMVDTEELV 3329
Score = 106 bits (264), Expect = 3e-22
Identities = 329/1810 (18%), Positives = 700/1810 (38%), Gaps = 208/1810 (11%)
Query: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
++ I W+ K ERE L+ E LE+ A ++ + W+ + Q + +
Sbjct: 2843 LNTIKTNWDTFNKQVKERENKLK------ESLEK-ALKYKEQVETLWPWIDKCQNNLEEI 2895
Query: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
F L+ A E ++ K ++++ ++ + G V+ ++ A L + D + + ++ +
Sbjct: 2896 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2955
Query: 512 LWDFLRQMVAARRERLLLNLELQKVFQ--------------------DLLYLMDWMEEMK 551
D + + + +++ L + K FQ D L + +
Sbjct: 2956 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3015
Query: 552 GRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL 611
LQ+Q + L ++ + L + + D+ V+A + S L+ +E+ Q
Sbjct: 3016 TMLQTQQ--KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ- 3072
Query: 612 VSERVAKLEQSYEALCELAAARRARLEE--------------SRRLWRFLWEVGEAEAWV 657
V E+ + LE + + R + R + +A++
Sbjct: 3073 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
Query: 658 REQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQ 717
++ + L+AS D T + L + T+ ++ G L+ +Q +L+ +
Sbjct: 3133 KKLEALMASNDNANK-TCKMMLATEETS--PDLVGIKRDLEALSKQCNKLL-------DR 3182
Query: 718 ASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGH 777
A AR +++ +RLE E +L + + L Q + + + P
Sbjct: 3183 AQAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEESQG-----------PVGME 3227
Query: 778 DEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLE---RHY 834
E Q L +EEI + + L + +++ QG L+ +
Sbjct: 3228 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3287
Query: 835 EELQARAGERARALEAAL--------ALYTMLSEAGACGLWVEEKEQWLNGLALPERLED 886
+ L + +RA L+ AL AL ++LS W+ + E+ + P +
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLS-------WMVDTEELVANQKPPSA--E 3338
Query: 887 LEVVQ---QRFETLEPEMNTLAAQITAVNDIAEQLLK-ANPPGKDRIVNTQEQLNHRWQQ 942
+VV+ Q + L+ ++ + + + E++ A P K +I+ L+ RW+
Sbjct: 3339 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3398
Query: 943 FRRLADGKKAALTS-ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKL 1001
A+ + L ++ Q +H W+ K + + + +G + + +
Sbjct: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458
Query: 1002 AGTERDLEAIAARVGELTREANALAAGHPAQAVA-------INARLREVQTGWEDLRATM 1054
E D+ + A++ G + ++ + ++L Q + +++
Sbjct: 3459 KALEDDI------INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKS 3512
Query: 1055 RRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVA--SEEGPATLPEAEALLAQHAALR 1111
R E L +A + F + WL ++ S + +T E L Q + LR
Sbjct: 3513 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST----EGLWKQQSELR 3568
Query: 1112 ---GEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
++ + + G E+ + + L ++ +LEA+ ++++ ++ L
Sbjct: 3569 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3628
Query: 1169 AQAHGFQGFLRDARQA---------EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMS 1219
QA L + +LS + VL E K+ ++ +
Sbjct: 3629 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3688
Query: 1220 TMDANGERIHGLLEAG--------RQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFL 1271
+D+ E LLE ++V+E N ++ R +D+I ++ ++ A +
Sbjct: 3689 LLDSLNEVSSALLELVPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILR-- 3743
Query: 1272 GRLRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAA 1328
Q F Q WI E K+++ D+ ++ + + Q + F E+
Sbjct: 3744 --------SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3794
Query: 1329 NKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAEL 1387
+KD +D + K G ++ T E K + +KL + + +D T Q + RA+
Sbjct: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYD---TICQINSERYLQLERAQS 3851
Query: 1388 ----FAQSCCALESWL---ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE 1440
F ++ L WL +S+ +QL + + ++ ++ + L +A + ++
Sbjct: 3852 LVNQFWETYEELWPWLTETQSIISQLPAP--ALEYETLRQQQEEHRQLRELIAEHKPHID 3909
Query: 1441 AIQAQAKALAQEDQGAG-EVERTSRAVEEKFRALCQPMRERCRRL-QASREQHQFHRDVE 1498
+ L + G G ++ A + + + + +++R L +A + QFH D
Sbjct: 3910 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFH-DKI 3968
Query: 1499 DEILWVTERL------PMASSMEHGK------DLPSVQLLMKKNQTLQKEI-QGHEPRIA 1545
D+IL ER+ P + S E K + +V + M+K Q L + + Q E IA
Sbjct: 3969 DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4028
Query: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWM 1604
+ + A A +L ++ +W+ + +E R +L D + A++F+ D +
Sbjct: 4029 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTI 4088
Query: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQ-----LAASSQDMIDHEH 1659
+ + + E + S VK+ Q + + + + + + S+ +
Sbjct: 4089 KDTQDFIRDLEDPGIDPSV---VKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGE 4145
Query: 1660 PESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC-QLRRELDDLEQWIQ-EREVVA 1717
P+ + +++ + L + +R ++L+E ++ Q + L + W+ +A
Sbjct: 4146 PDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA 4205
Query: 1718 ASHELGQDYEHVTMLRDKFREFSRDT--STIGQERVDSANALANGLIAGGHAARATVAEW 1775
+ +G D E V ++ ++F + I ER++ L + + + TV +
Sbjct: 4206 SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE-ESDKHTVQDP 4264
Query: 1776 KDSLNEAWADLLELLDTRGQVLAAAY-ELQRFLHGARQALARVQHKQQQLPDG--TGRDL 1832
L W L E + R L A L +F H + LA + H + L + G D
Sbjct: 4265 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4324
Query: 1833 NAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
A E +H ++D+ A V+ V G+ L ++ AG++A + ++ + + W +
Sbjct: 4325 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4384
Query: 1893 QGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
+ R+Q L + + F + +L W+ + + A + + K Q
Sbjct: 4385 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS---KPLGGLPETAKEQLN 4441
Query: 1952 IKAEI----EARADRFSSCIDMGKELLARSHYAAE-EISEKLSQLQARRQETAEKWQEKM 2006
+ E+ EA+ + + S + G+++LAR +AE I + ++ L+ + + K E+
Sbjct: 4442 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4501
Query: 2007 DWLQLVLEV-LVFGRDAGMAEAWLCSQEPLVRSAEL-GCTVDEVESLIKRHEAFQKSAVA 2064
L+ L + + F WL E + A +D V I H+ F +
Sbjct: 4502 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4561
Query: 2065 WEERFCALEK 2074
E+ L+K
Sbjct: 4562 HREQIIELDK 4571
Score = 68.9 bits (167), Expect = 6e-11
Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 16/282 (5%)
Query: 535 KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASA 594
K QDLL +W++EM+ +L + G L VE L+ H+ V I ++ S
Sbjct: 606 KFVQDLL---NWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 662
Query: 595 LRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAE 654
++ P K +E++ +LE Y L + + L+ L F+
Sbjct: 663 IQMTAPLK-------LTYAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNEL 712
Query: 655 AWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG 714
W+ E++ + D T R + H L E+ + +K E +QL+ E HP
Sbjct: 713 IWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 772
Query: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAW---LVDALRLVS 771
A A +Q QW + L + Q + + + ++F DA + + L DA++
Sbjct: 773 RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKY 832
Query: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL 813
S + + L ++ +EE+ ++ T+ L +A +
Sbjct: 833 SCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 874
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/266 (18%), Positives = 109/266 (40%), Gaps = 24/266 (9%)
Query: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPES 1662
W+ E ++ + E D S ++ ++ H+ + +A+ ++ ++ + S M P
Sbjct: 614 WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLK 670
Query: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLEQWIQEREVVAASHE 1721
+ + +++ YA L + + L H + + EL W+ E+E +++
Sbjct: 671 LTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELI----WLNEKEEEEVAYD 726
Query: 1722 LGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNE 1781
+ ++ +D E R+ +E + S +A L+ H AR T+ ++ ++
Sbjct: 727 WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 785
Query: 1782 AWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRR 1841
W+ +L+L Q + F + A++A ++ N +A+QR+
Sbjct: 786 QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR--------------NLKDAIQRK 831
Query: 1842 H-CAYEHDIQALSPQVQQVQDDGHRL 1866
+ C I L VQ+ ++ L
Sbjct: 832 YSCDRSSSIHKLEDLVQESMEEKEEL 857
Score = 45.8 bits (107), Expect = 5e-04
Identities = 52/280 (18%), Positives = 110/280 (39%), Gaps = 28/280 (10%)
Query: 296 VLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSF-NSYRTVE 354
+LD + E + K+ +LL W+++ V L+ + + L V++ L++ N +R +E
Sbjct: 593 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 649
Query: 355 KPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALR 414
+ ++ + + T KL Y E+L + E + L
Sbjct: 650 EFESSLKEAKISEIQMTAPLKL------TYA--------------EKLHRLESQYAKLLN 689
Query: 415 TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDI 474
T ++ L+ L F +A WL+E + ++ + H + ++
Sbjct: 690 TSRNQERHLDTLH-NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 748
Query: 475 VAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534
+++V +A +L E + I A + + W ++ Q+ + + N
Sbjct: 749 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 808
Query: 535 KVFQDLLYLMDWMEEMKGRLQ---SQDLGRHLAGVEDLLQ 571
+ F D D++ +K +Q S D + +EDL+Q
Sbjct: 809 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ 848
Score = 45.8 bits (107), Expect = 5e-04
Identities = 205/1138 (18%), Positives = 417/1138 (36%), Gaps = 193/1138 (16%)
Query: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064
+++LE + +G +T + + A + R E+ +++ + +
Sbjct: 1113 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLR-SELNVVLQNMNQVYSMSSTYIDKL 1171
Query: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSR 1123
+ + L++ +A + +T + EE A E L++ R EV+ + +
Sbjct: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF-- 1229
Query: 1124 LRALGEEVTRDQADPQCLFLRQRLEALGTGW-----EELGRMWESRQGRLAQAHGFQGFL 1178
AL +E+ + +A +F + L W ++L W++ ++
Sbjct: 1230 -HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR------- 1281
Query: 1179 RDARQAEGVLSSQEYVL-SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQ 1237
R EG+ S +Y ++ + +Q + +K+++ N + + L +
Sbjct: 1282 --LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQE---NQPENSKTLATQLNQQKM 1336
Query: 1238 LVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ---HFLQDCHELKLWI 1294
LVSE + K+ E Q A+Q+ ++D Q + D +
Sbjct: 1337 LVSEIEMKQSKMDEC-----------QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1385
Query: 1295 DEKMLTAQDVSYDEARNLHTKWQKHQAFMAE-LAANKDWLDKVDKEGRELTLEKPELKAL 1353
+M ++ D+ E +L T++ M + + D L ++++E + L EK E
Sbjct: 1386 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHV-- 1443
Query: 1354 VSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK 1413
EK ++L + + T L DA +A S + + S + + +
Sbjct: 1444 --EKAKELQKWVSNISKT-------LKDAEKAGKPPFS----KQKISSEEISTKKEQLSE 1490
Query: 1414 DLTSVNILLKKQ--QMLEWEMAVREKEVEAIQAQAKAL-------AQEDQGAGEVERTSR 1464
L ++ + L K +M + E EK+V+ +Q L QE Q +G+V+ +
Sbjct: 1491 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK 1550
Query: 1465 AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQ 1524
V E+ + + ++ C L + + H++ + G ++
Sbjct: 1551 IVAERQQEYKEKLQGICDLLTQTENRLIGHQE----------------AFMIGDGTVELK 1594
Query: 1525 LLMKKNQTLQKEIQGHEPRIAD--------LRERQRALG---AAAAGPELAELQEMWKRL 1573
K + LQK++QG +A+ L+E L A +L E + ++L
Sbjct: 1595 KYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1654
Query: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL------SAQAEV 1627
+ E K L+ + ++ E A + + E E D L S +A
Sbjct: 1655 NLKAEQSKKELDKVVTTA--IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1712
Query: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPEST---RISIRQAQVDKLYAGLKE--- 1681
K QV+EQ + + + A +D ++ E+ ++ Q +++ Y +K
Sbjct: 1713 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1772
Query: 1682 --------------------------LAGERRERLQEHLRLCQ----------------- 1698
L+ E +E+LQ++++ +
Sbjct: 1773 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1832
Query: 1699 --LRRELD-------DLEQWIQEREVVAASHELGQDYEHVTMLR-DKFREFSRDT----- 1743
L+ EL+ + E W+Q+ E + E G D + M + + + FS D
Sbjct: 1833 HSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG 1892
Query: 1744 ----STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLA- 1798
TI RV A + G AT E + L+ A D L ++ VL
Sbjct: 1893 DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA-TDRFRSLYSKCNVLGN 1951
Query: 1799 ----AAYELQRFLHGARQALARVQ--------HKQQQL---PDGTGRDLNAAEALQRRHC 1843
+ Q + + LA +Q H + + P R L +ALQ +
Sbjct: 1952 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2011
Query: 1844 AYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQ-L 1902
+ + ++ L + + D L A +I + + + + L S R + L
Sbjct: 2012 SQQVAVEKLKKTAEVLLDARGSLLPA-----KNDIQKTLDDIVGRYEDLSKSVNERNEKL 2066
Query: 1903 LLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ-ERPRDVSSADLVIKNQQGIKAEIEARAD 1961
+ T + E++ WM V + Q + P + ++ +I ++ +I R
Sbjct: 2067 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2126
Query: 1962 RFSSCIDMGKELLARSH-YAAEEISEKLSQLQARRQETAEKWQE---KMDWLQLVLEV 2015
++ + K+ + + A + K+ L AR E + K +E KM+ L+ +E+
Sbjct: 2127 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL 2184
Score = 43.1 bits (100), Expect = 0.003
Identities = 62/299 (20%), Positives = 118/299 (39%), Gaps = 36/299 (12%)
Query: 1378 SLFDANRAE-----LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML---- 1428
SL D N E F Q L +W++ +Q QL ++G DL SV L+ + +
Sbjct: 592 SLLDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 648
Query: 1429 -EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQAS 1487
E+E +++E ++ IQ A E+ R +E ++ L R + R L
Sbjct: 649 EEFESSLKEAKISEIQMTAPLKLT------YAEKLHR-LESQYAKLLNTSRNQERHLDT- 700
Query: 1488 REQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL 1547
H F +E++W+ E+ + + + ++ + L +E+ E I +
Sbjct: 701 --LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSV 758
Query: 1548 RERQRALGAAAAGPEL------AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
+E L L A +Q W + + + +++ +F+ DA EA
Sbjct: 759 QEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 818
Query: 1602 AWMGEQELHMMGQEKAKDELSAQAE-----VKKHQVLEQALADYAQTIHQLAASSQDMI 1655
++ + L Q K + S+ V++ ++ L Y TI L ++ +I
Sbjct: 819 DYL--RNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 875
Score = 40.8 bits (94), Expect = 0.016
Identities = 37/205 (18%), Positives = 84/205 (40%), Gaps = 16/205 (7%)
Query: 1497 VEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGA 1556
V+D + WV E E G DLPSV+ ++ ++ + + I+ E + + + + +
Sbjct: 608 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM-- 665
Query: 1557 AAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRD--------AAEAEAWMGEQE 1608
A L+ + H LE + +L + R Q+ + D A W+ E+E
Sbjct: 666 ------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKE 719
Query: 1609 LHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIR 1668
+ + ++ + + H L + L + I + ++ ++ HP I
Sbjct: 720 EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 779
Query: 1669 QAQVDKLYAGLKELAGERRERLQEH 1693
+A + ++ + +L + ++E+
Sbjct: 780 RAAMQTQWSWILQLCQCVEQHIKEN 804
Score = 40.4 bits (93), Expect = 0.021
Identities = 44/225 (19%), Positives = 86/225 (38%), Gaps = 5/225 (2%)
Query: 758 DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTL 817
D+ W+ + + E G D S ++ H+ + I +L + + L
Sbjct: 610 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPL 669
Query: 818 SRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNG 877
T ++ LE Y +L + + R L+ L+ +S A +W+ EKE+
Sbjct: 670 KLT--YAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVA 724
Query: 878 LALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLN 937
ER ++ + L E++ I +V +IAEQLL N P + I + +
Sbjct: 725 YDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQ 784
Query: 938 HRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIE 982
+W +L + + + + + E ++R I+
Sbjct: 785 TQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 829
Score = 33.5 bits (75), Expect = 2.6
Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 8/100 (8%)
Query: 1914 KAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGK-- 1971
K V++L+ W+DE+ +Q+D E D+ S + ++N + + IE F S + K
Sbjct: 606 KFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE----EFESSLKEAKIS 661
Query: 1972 --ELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
++ A E +L A+ T+ + +D L
Sbjct: 662 EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL 701
Score = 32.0 bits (71), Expect = 7.5
Identities = 105/572 (18%), Positives = 223/572 (38%), Gaps = 70/572 (12%)
Query: 1565 ELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAE-AEAWMGE--------QELHMMGQE 1615
+L E W+ + +++ R + LE ++ ++YRD + W+ + QE +
Sbjct: 1266 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 1325
Query: 1616 KAKDELSAQAEVKKHQVLEQALADYAQT-IHQLAASSQD----------MIDHEHPESTR 1664
+L+ Q + ++Q+ D Q Q +A+ +D M+D + +
Sbjct: 1326 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1385
Query: 1665 ISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQ 1724
Q+ D + +L R L ++ D L++ +E + + +
Sbjct: 1386 RRRMQSSADLIIQEFMDL--RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK--- 1440
Query: 1725 DYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWA 1784
EHV +K +E + S I + D+ A + + ++ K+ L+EA
Sbjct: 1441 --EHV----EKAKELQKWVSNISKTLKDAEKA-GKPPFSKQKISSEEISTKKEQLSEALQ 1493
Query: 1785 DLLELLDTRGQVLA--AAYELQRFLHGARQA--LARVQHKQQQLPDGTGRDLNAAEAL-Q 1839
+ L G + EL++ + +++ L + +Q T D+ E +
Sbjct: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVA 1553
Query: 1840 RRHCAYEHDIQALSPQVQQVQDDGHRLQKAY-AGDKAEEIGRHMQAVAEAWAQLQGSSAA 1898
R Y+ +Q + + Q ++ Q+A+ GD E+ ++ E +QGS+ A
Sbjct: 1554 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1613
Query: 1899 RRQLLLDT-------------TDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLV 1945
+++ +T DK + + E + +++NL+ + ++ D +
Sbjct: 1614 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1673
Query: 1946 IKNQQGIKA--EIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQ 2003
+ + + A ++E + + +D + S A + + + Q QE K
Sbjct: 1674 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSA 1733
Query: 2004 --EKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKS 2061
E+ + +LE V G+ G + L Q V++ + E +I +H+A
Sbjct: 1734 IGEEDEVNGNLLETDVDGQ-VGTTQENLNQQYQKVKA--------QHEKIISQHQAV--- 1781
Query: 2062 AVAWEERFCALEK---LTALEEREKERKRKRE 2090
+A + LEK + EE+EK +K +E
Sbjct: 1782 IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1813
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.129 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,917,591
Number of Sequences: 37866
Number of extensions: 4087847
Number of successful extensions: 33668
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 163
Number of HSP's successfully gapped in prelim test: 873
Number of HSP's that attempted gapping in prelim test: 23635
Number of HSP's gapped (non-prelim): 6324
length of query: 2390
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2271
effective length of database: 13,741,464
effective search space: 31206864744
effective search space used: 31206864744
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.