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Search of human proteins with 56790299
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56790299 pleckstrin and Sec7 domain containing [Homo
sapiens]
(1024 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens] 2078 0.0
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens] 628 e-179
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6... 588 e-167
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ... 586 e-167
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens] 473 e-133
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 117 7e-26
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 117 7e-26
gi|4758968 cytohesin 3 [Homo sapiens] 115 2e-25
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 110 9e-24
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 110 9e-24
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens] 104 5e-22
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens] 104 5e-22
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti... 101 4e-21
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens] 101 4e-21
gi|7019505 cytohesin 4 [Homo sapiens] 97 1e-19
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr... 91 6e-18
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens] 89 3e-17
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens] 89 3e-17
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange... 82 2e-15
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 72 2e-12
gi|163965366 nascent polypeptide-associated complex alpha subuni... 70 8e-12
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 69 3e-11
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens] 68 5e-11
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens] 68 5e-11
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom... 63 1e-09
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom... 63 1e-09
gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens] 62 2e-09
gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein ... 61 5e-09
gi|111118968 collagen, type XI, alpha 2 isoform 3 preproprotein ... 61 5e-09
gi|111118970 collagen, type XI, alpha 2 isoform 1 preproprotein ... 61 5e-09
>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
Length = 1024
Score = 2078 bits (5383), Expect = 0.0
Identities = 1024/1024 (100%), Positives = 1024/1024 (100%)
Query: 1 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL 60
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
Sbjct: 1 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL 60
Query: 61 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP 120
GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
Sbjct: 61 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP 120
Query: 121 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP 180
GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
Sbjct: 121 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP 180
Query: 181 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW 240
PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
Sbjct: 181 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW 240
Query: 241 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD 300
EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
Sbjct: 241 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD 300
Query: 301 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE 360
IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
Sbjct: 301 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE 360
Query: 361 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY 420
EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
Sbjct: 361 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY 420
Query: 421 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ 480
TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
Sbjct: 421 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ 480
Query: 481 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA 540
RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
Sbjct: 481 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA 540
Query: 541 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF 600
LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
Sbjct: 541 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF 600
Query: 601 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL 660
TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
Sbjct: 601 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL 660
Query: 661 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS 720
NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
Sbjct: 661 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS 720
Query: 721 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK 780
LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
Sbjct: 721 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK 780
Query: 781 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR 840
RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
Sbjct: 781 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR 840
Query: 841 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ 900
TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
Sbjct: 841 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ 900
Query: 901 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR 960
EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
Sbjct: 901 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR 960
Query: 961 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG 1020
VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
Sbjct: 961 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG 1020
Query: 1021 RRKP 1024
RRKP
Sbjct: 1021 RRKP 1024
>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
Length = 771
Score = 628 bits (1619), Expect = e-179
Identities = 348/634 (54%), Positives = 425/634 (67%), Gaps = 41/634 (6%)
Query: 397 DGP------DSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPA 450
DGP D FS FE ILES +GT Y+SL SL+ L+ + S +FE P P
Sbjct: 126 DGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDS-CVSFEAPLTPLI 184
Query: 451 PRPDPPAPAPLAPL-------EPDSGTSSAADGPWTQRGEEEEAEARAKLAPGR----EP 499
+ +P P A L E D G ++ DG + +R++ R
Sbjct: 185 QQRARDSPEPGAGLGIGDMAFEGDMG-AAGGDGELGSPLRRSISSSRSENVLSRLSLMAM 243
Query: 500 PSPCHSEDSLGLGAAP------------LGSEPPLSQLVSDSDSELDSTERLALGSTDTL 547
P+ H + G G S+P L +SDSDSEL S+E L GS D L
Sbjct: 244 PNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPL 303
Query: 548 SNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQ 607
+NG + EAA RLA+RLY L+GF++ DVAR LGKNN+FS+LVAGEYL FF F+G+TLD
Sbjct: 304 ANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDG 363
Query: 608 ALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGH 667
ALR FLK LMGETQERERVL HFS+RY QCNP+ +SEDG HTLTCALMLLNTDLHGH
Sbjct: 364 ALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGH 423
Query: 668 NIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP 727
NIGK+M+C FI NL+ LNDG DF ++LLK LY+SIKNEKL+WAIDE+ELR+SLSEL D
Sbjct: 424 NIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDD 483
Query: 728 N-----PKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRG 782
KV + + GG+ PFLD+ A YKHG L RK HAD D ++TPRG+RG
Sbjct: 484 KFGTGTKKVTRILDGGN-----PFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRG 538
Query: 783 WKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTA 842
WK F+ +LKG ILYLQK+EY+P KALSE +LKNAI +HHALATRASDYSK+ +V L+TA
Sbjct: 539 WKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTA 598
Query: 843 DWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEE 902
DWRVFLFQAPS E+M SWI RIN+VAA+FSAP FPAAVSS KKF RPLLPS TRL QEE
Sbjct: 599 DWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEE 658
Query: 903 QVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVK 962
Q+R+HE KL+ + +EL EHR + + + KEAEE R KE YL FEKSRY TY LL +K
Sbjct: 659 QLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMK 718
Query: 963 LKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSL 996
+K GS++L+ +EA LA + L +HSSP+L
Sbjct: 719 IKVGSDDLERIEARLATLEGDDPSLRKTHSSPAL 752
>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
isoform a [Homo sapiens]
Length = 1047
Score = 588 bits (1515), Expect = e-167
Identities = 329/638 (51%), Positives = 428/638 (67%), Gaps = 52/638 (8%)
Query: 391 GTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPA 450
G + D D +S FE IL++ + Y S SLE L S + +F+FE+P P
Sbjct: 430 GPGYTEDSTDVYSSQFETILDNT----SLYYSAESLETLYSEPDS---YFSFEMPLTPMI 482
Query: 451 PRPDPPAPAPLAPLEPDSG------TSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCH 504
+ L E SG S +ADG + + G S
Sbjct: 483 QQRIKEGGQFL---ERTSGGGHQDILSVSADGGIVMGYS-------SGVTNGLNDAS--- 529
Query: 505 SEDSLGLGAAP----LGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQR 560
DS+ P GS + ++ SE+ STE L + + LSNG +++EAA+R
Sbjct: 530 --DSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKR 587
Query: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620
LAKRLY+LD F+++DVA+HLGKNN+FSKLVA EYLKFF FTGMTLDQ+LR F K +L+G
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
Query: 621 ETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIG 680
ETQERERVL HFS RYF CNP+ ++S+DG H LTCA+MLLNTDLHGHNIGK+MTC +FI
Sbjct: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707
Query: 681 NLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP-----NPKVIKRI 735
NL+G+N+G DF ++LLKALY+SIKNEKL+WA+D+EE ++S SE + +PK I RI
Sbjct: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 767
Query: 736 SGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMIL 795
GS ++PFLD+ +P AAVYK G L RK+HAD D +KTPRGKRGWK+F+ +LKG +L
Sbjct: 768 ----GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVL 823
Query: 796 YLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLE 855
YLQK+EYKP KALSE +LKNA+S+HHALA++A+DY K+P+VF L+TADWRV LFQ S E
Sbjct: 824 YLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPE 883
Query: 856 QMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMA 915
+MQ WI +IN VAA+FSAPPFPAA+ SQKKFSRPLLP+ T+LSQEEQ+++HE+KLK +
Sbjct: 884 EMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQIT 943
Query: 916 SELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEA 975
+EL EHR+ KK + K+ +E + K+ YLEFEK+RY Y ++ LK G +EL
Sbjct: 944 TELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSI----LKEGGKEL----- 994
Query: 976 ALAQAGSTEDGLPPSHSSPSLQPKPSS-QPRAQRHSSE 1012
L+ S GL SHSSPSL P S + +R+ SE
Sbjct: 995 -LSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSE 1031
>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
isoform b [Homo sapiens]
Length = 513
Score = 586 bits (1511), Expect = e-167
Identities = 294/491 (59%), Positives = 378/491 (76%), Gaps = 20/491 (4%)
Query: 528 DSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFS 587
++ SE+ STE L + + LSNG +++EAA+RLAKRLY+LD F+++DVA+HLGKNN+FS
Sbjct: 21 EAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFS 80
Query: 588 KLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSE 647
KLVA EYLKFF FTGMTLDQ+LR F K +L+GETQERERVL HFS RYF CNP+ ++S+
Sbjct: 81 KLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQ 140
Query: 648 DGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEK 707
DG H LTCA+MLLNTDLHGHNIGK+MTC +FI NL+G+N+G DF ++LLKALY+SIKNEK
Sbjct: 141 DGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEK 200
Query: 708 LQWAIDEEELRRSLSELADP-----NPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGA 762
L+WA+D+EE ++S SE + +PK I RI GS ++PFLD+ +P AAVYK G
Sbjct: 201 LEWAVDDEEKKKSPSESTEEKANGTHPKTISRI----GSTTNPFLDIPHDPNAAVYKSGF 256
Query: 763 LVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHA 822
L RK+HAD D +KTPRGKRGWK+F+ +LKG +LYLQK+EYKP KALSE +LKNA+S+HHA
Sbjct: 257 LARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHA 316
Query: 823 LATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSS 882
LA++A+DY K+P+VF L+TADWRV LFQ S E+MQ WI +IN VAA+FSAPPFPAA+ S
Sbjct: 317 LASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGS 376
Query: 883 QKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKE 942
QKKFSRPLLP+ T+LSQEEQ+++HE+KLK + +EL EHR+ KK + K+ +E + K+
Sbjct: 377 QKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKD 436
Query: 943 AYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSS 1002
YLEFEK+RY Y ++ LK G +EL L+ S GL SHSSPSL P S
Sbjct: 437 HYLEFEKTRYEMYVSI----LKEGGKEL------LSNDESEAAGLKKSHSSPSLNPDTSP 486
Query: 1003 -QPRAQRHSSE 1012
+ +R+ SE
Sbjct: 487 ITAKVKRNVSE 497
>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
Length = 1056
Score = 473 bits (1217), Expect = e-133
Identities = 340/895 (37%), Positives = 450/895 (50%), Gaps = 94/895 (10%)
Query: 167 LPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPR 226
LPG L PP G D SS P G G R T P G + +S+P
Sbjct: 195 LPGDTGLHSSPPENEDSGED---SSEPEGEGQAWLREGTPDSSP-QWGAEEESMFFSNPL 250
Query: 227 EVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQA----PPSPPG-VGSRQGSGVAVGRAA 281
++S + + F +G+ D + PE PP P V S +G A
Sbjct: 251 FLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDTVLWELESEPDLGDGA 310
Query: 282 KYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPL--- 338
S P+ Y+ I A A+ A + P G PAP P
Sbjct: 311 AISGHCTPPFPVPIYKPHSI--CWASVAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDE 368
Query: 339 --------------PGPHPSLGSGNEDEDDDEAGG----EEDVDDEVFEASEGARPGSRM 380
P HP + + + GG + ++ + + EG P +
Sbjct: 369 ALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESL 428
Query: 381 PLK-SPVPFL-PGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSP 438
P +P P+ P +SP P+S S PGP SP
Sbjct: 429 PCTLAPCPWRSPASSPEPSSPESES--------------------------RGPGPRPSP 462
Query: 439 FFTFELPPQ----PPAPRPDPPAPAPLAPL-----EPDSGTSSAADGPWTQRGEEEEAEA 489
+ E PQ P A + L E S G + GEE ++E
Sbjct: 463 ASSQEGSPQLQHHSSGILPKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEG 522
Query: 490 RAKLAPGREPPSPCH--SEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTL 547
A+ A + H S + L S P S + E +R G D L
Sbjct: 523 TARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSPE--EGQRPPAG--DKL 578
Query: 548 SNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQ 607
+NG + + + A LA RLYRL+GFRK++VA +L KNNDFS+ VA EYL FF F G +LD+
Sbjct: 579 ANGVRNN-KVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDR 637
Query: 608 ALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGH 667
ALR FL+ L L GETQERER+L FS+R+ CNP S D HTLTCA+MLLNTDLHG
Sbjct: 638 ALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQ 697
Query: 668 NIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP 727
NIGK M+C +FI NL GL DGG+FP+ELLKALY SI++EKL+WA+DEE+ R E A P
Sbjct: 698 NIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTAR--PEKAQP 755
Query: 728 NPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFH 787
S +G S PFL L +P YK G L RK+H D D +KTP GKRGWK FH
Sbjct: 756 --------SLPAGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFH 807
Query: 788 GILKGMILYLQK---EEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADW 844
+L+GM+LY K + G++L + + +HH+LAT A+ Y+K+PHVF LRTADW
Sbjct: 808 TLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQLRTADW 867
Query: 845 RVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQV 904
R++LFQAP+ ++M SWI RIN+ AA SAPPFPAAV SQ++F RP+LP + S EEQ
Sbjct: 868 RLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSLEEQH 927
Query: 905 RTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLK 964
R+HE L A A +L + + ++GRG+E EE R ++ YLE+EK+RY TY LL +L
Sbjct: 928 RSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQLLVARLH 987
Query: 965 AGSEELDAVEAALA-QAGSTED---GLPPSHSSPSL-QPKPSSQPRAQRHSSEPR 1014
S+ LD E L +AG T + L SHSSPSL Q + + + +R+ SE R
Sbjct: 988 CPSDALDLWEEQLGREAGGTREPKLSLKKSHSSPSLHQDEAPTTAKVKRNISERR 1042
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 117 bits (292), Expect = 7e-26
Identities = 61/154 (39%), Positives = 91/154 (59%)
Query: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620
+A+ LY+ +G K + +LG+ ++F+ V +++ FT + L QALR FL L G
Sbjct: 97 IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156
Query: 621 ETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIG 680
E Q+ +R++ F+QRY QCN S D + L+ A+++LNT LH N+ + T FI
Sbjct: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216
Query: 681 NLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714
G+NDGGD P ELL+ LY SIKNE + D+
Sbjct: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDD 250
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 117 bits (292), Expect = 7e-26
Identities = 61/154 (39%), Positives = 91/154 (59%)
Query: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620
+A+ LY+ +G K + +LG+ ++F+ V +++ FT + L QALR FL L G
Sbjct: 97 IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156
Query: 621 ETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIG 680
E Q+ +R++ F+QRY QCN S D + L+ A+++LNT LH N+ + T FI
Sbjct: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216
Query: 681 NLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714
G+NDGGD P ELL+ LY SIKNE + D+
Sbjct: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDD 250
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 115 bits (289), Expect = 2e-25
Identities = 59/154 (38%), Positives = 90/154 (58%)
Query: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620
+A+ LY+ +G K + +LG+ ++F+ V +++ F + L QALR FL L G
Sbjct: 101 VAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG 160
Query: 621 ETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIG 680
E Q+ +R++ F+ RY CNP S D + L+ A+++LNT LH HN+ + T FI
Sbjct: 161 EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIA 220
Query: 681 NLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714
G+N+GGD P ELL+ LY SIKNE + D+
Sbjct: 221 MNRGINEGGDLPEELLRNLYESIKNEPFKIPEDD 254
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 110 bits (274), Expect = 9e-24
Identities = 56/156 (35%), Positives = 88/156 (56%)
Query: 559 QRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELAL 618
+ +A+ LY+ +G K + +LG+ + + V ++ FT + L QALR FL L
Sbjct: 94 EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153
Query: 619 MGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678
GE Q+ +R++ F+QRY CNP S D + L+ A+++LNT LH N+ + F
Sbjct: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213
Query: 679 IGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714
+ G+N+GGD P ELL+ LY SI+NE + D+
Sbjct: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 110 bits (274), Expect = 9e-24
Identities = 56/156 (35%), Positives = 88/156 (56%)
Query: 559 QRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELAL 618
+ +A+ LY+ +G K + +LG+ + + V ++ FT + L QALR FL L
Sbjct: 94 EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153
Query: 619 MGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678
GE Q+ +R++ F+QRY CNP S D + L+ A+++LNT LH N+ + F
Sbjct: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213
Query: 679 IGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714
+ G+N+GGD P ELL+ LY SI+NE + D+
Sbjct: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249
>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
Length = 949
Score = 104 bits (259), Expect = 5e-22
Identities = 114/436 (26%), Positives = 177/436 (40%), Gaps = 63/436 (14%)
Query: 318 QPSSEGPPGTAYPPAPRP-----GPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASE 372
Q S E P T PP RP PLP P + SG ++ E G E +
Sbjct: 321 QQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPG--CLECRD 378
Query: 373 GARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASP 432
+ +PL + P + +D D S + + E A G S +L+ P
Sbjct: 379 FRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYE---ADGCS--PHGTLKHKGPP 433
Query: 433 GPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAK 492
G P + P P P P PP P P AP +SGT + + G+ E A +
Sbjct: 434 GRAPIPHRHY---PAPEGPAPAPPGPLPPAP---NSGTGPSGVAGGRRLGKCEAAGENSD 487
Query: 493 LAPGREPPSPCHSEDSLGLGAAPLGS----EPPLSQLVSDS--------------DSELD 534
S +S +++ + EPP + L + ++++
Sbjct: 488 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV 547
Query: 535 STERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEY 594
+G L+ K + Q L +R + D VA + + S+ + GE+
Sbjct: 548 QRRHYRIG----LNLFNKKPEKGIQYLIERGFLSD--TPVGVAHFILERKGLSRQMIGEF 601
Query: 595 L----KFFV------------FTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQ 638
L K F F+ M LD ALR F + + GE Q+ ER++ FSQRY
Sbjct: 602 LGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCV 661
Query: 639 CNP---EALSSEDGAHTLTCALMLLNTDLHGHNI--GKRMTCGDFIGNLEGLNDGGDFPR 693
CNP + D L A++LLNTD++ ++ ++M DFI NL G+++G D PR
Sbjct: 662 CNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPR 721
Query: 694 ELLKALYSSIKNEKLQ 709
+LL +Y I+ +L+
Sbjct: 722 DLLVGIYQRIQGRELR 737
Score = 35.0 bits (79), Expect = 0.36
Identities = 46/153 (30%), Positives = 61/153 (39%), Gaps = 23/153 (15%)
Query: 392 TSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEA-LASPGPTQSPFFTFELPPQPPA 450
+ P ++ P S E + + +S TS + L L P QSP P PP
Sbjct: 279 SGPMSEEPGSAQ--LEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEP-PPQ 335
Query: 451 PRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLG 510
RP+ APAPL P+ P + + D G EE R PG C
Sbjct: 336 GRPEFWAPAPLPPVPPPVPSGTRED------GSREEGTRR---GPG------CLECRDFR 380
Query: 511 LGAAPLGSEPPLSQLVSDSDSELDSTERLALGS 543
L AA L PL + SDS +D ++R GS
Sbjct: 381 LRAAHL----PLLTIEPPSDSSVDLSDRSDRGS 409
>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
Length = 1488
Score = 104 bits (259), Expect = 5e-22
Identities = 114/436 (26%), Positives = 177/436 (40%), Gaps = 63/436 (14%)
Query: 318 QPSSEGPPGTAYPPAPRP-----GPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASE 372
Q S E P T PP RP PLP P + SG ++ E G E +
Sbjct: 526 QQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPG--CLECRD 583
Query: 373 GARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASP 432
+ +PL + P + +D D S + + E A G S +L+ P
Sbjct: 584 FRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYE---ADGCS--PHGTLKHKGPP 638
Query: 433 GPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAK 492
G P + P P P P PP P P AP +SGT + + G+ E A +
Sbjct: 639 GRAPIPHRHY---PAPEGPAPAPPGPLPPAP---NSGTGPSGVAGGRRLGKCEAAGENSD 692
Query: 493 LAPGREPPSPCHSEDSLGLGAAPLGS----EPPLSQLVSDS--------------DSELD 534
S +S +++ + EPP + L + ++++
Sbjct: 693 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV 752
Query: 535 STERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEY 594
+G L+ K + Q L +R + D VA + + S+ + GE+
Sbjct: 753 QRRHYRIG----LNLFNKKPEKGIQYLIERGFLSD--TPVGVAHFILERKGLSRQMIGEF 806
Query: 595 L----KFFV------------FTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQ 638
L K F F+ M LD ALR F + + GE Q+ ER++ FSQRY
Sbjct: 807 LGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCV 866
Query: 639 CNP---EALSSEDGAHTLTCALMLLNTDLHGHNI--GKRMTCGDFIGNLEGLNDGGDFPR 693
CNP + D L A++LLNTD++ ++ ++M DFI NL G+++G D PR
Sbjct: 867 CNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPR 926
Query: 694 ELLKALYSSIKNEKLQ 709
+LL +Y I+ +L+
Sbjct: 927 DLLVGIYQRIQGRELR 942
Score = 41.6 bits (96), Expect = 0.004
Identities = 54/190 (28%), Positives = 66/190 (34%), Gaps = 31/190 (16%)
Query: 324 PPGTAYPPAPRP-----GPLPGP-HPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPG 377
PP +A P P GP+PGP H +LG AGG P
Sbjct: 1309 PPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRG-AGGHPQF-----------APH 1356
Query: 378 SRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPT-- 435
R PL P LP SP+ P + + + SH + A PG +
Sbjct: 1357 GRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYS 1416
Query: 436 -----QSPFFTFE-LPPQPPAPRPDPPAP-APLAPLEPDSGTSSA-ADGPWTQRGEEEEA 487
QSP +PP P P PP+P P +PL P S A GP G
Sbjct: 1417 HPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGP---PGTANPP 1473
Query: 488 EARAKLAPGR 497
A K P R
Sbjct: 1474 SANPKAKPSR 1483
Score = 35.0 bits (79), Expect = 0.36
Identities = 46/153 (30%), Positives = 61/153 (39%), Gaps = 23/153 (15%)
Query: 392 TSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEA-LASPGPTQSPFFTFELPPQPPA 450
+ P ++ P S E + + +S TS + L L P QSP P PP
Sbjct: 484 SGPMSEEPGSAQ--LEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEP-PPQ 540
Query: 451 PRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLG 510
RP+ APAPL P+ P + + D G EE R PG C
Sbjct: 541 GRPEFWAPAPLPPVPPPVPSGTRED------GSREEGTRR---GPG------CLECRDFR 585
Query: 511 LGAAPLGSEPPLSQLVSDSDSELDSTERLALGS 543
L AA L PL + SDS +D ++R GS
Sbjct: 586 LRAAHL----PLLTIEPPSDSSVDLSDRSDRGS 614
Score = 35.0 bits (79), Expect = 0.36
Identities = 73/309 (23%), Positives = 101/309 (32%), Gaps = 55/309 (17%)
Query: 188 LYSSLPNGLGGPPERLATLFGGPADTGFLN-QGDTWSSPREVSSHAQRIARAKWEFFYGS 246
L S++P G ++ +F P+ L D S EV + ++ E G
Sbjct: 1046 LLSAVPGG----ERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGM 1101
Query: 247 LDPPSS---GAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSET-DLDTVPLRCYRETDID 302
+ P +S GAK + + G+G + R A S DL R R +
Sbjct: 1102 MRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSV-- 1159
Query: 303 EVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEED 362
DS IE S P PP P P P E +
Sbjct: 1160 ------GSLDSTIEGSVISSPRPHQRMPPPPPPPP----------PEEYKSQRPVSNSSS 1203
Query: 363 VDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTS 422
+F + G P P P T ++ S S H G S+
Sbjct: 1204 FLGSLFGSKRGKGPFQMPP--------PPTGQASASSSSASSTHHH--HHHHHHGHSHGG 1253
Query: 423 L-------ASLEALAS-----PGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLE--PDS 468
L + L+AL + PGP P+ LPPQ P+ P P P PL L P
Sbjct: 1254 LGVLPDGQSKLQALHAQYCQGPGPAPPPY----LPPQQPSLPPPPQQPPPLPQLGSIPPP 1309
Query: 469 GTSSAADGP 477
S+ GP
Sbjct: 1310 PASAPPVGP 1318
Score = 31.6 bits (70), Expect = 4.0
Identities = 36/125 (28%), Positives = 41/125 (32%), Gaps = 34/125 (27%)
Query: 2 AQGAMRFCSEGDCAISPPRCPRRWLP-EGPVPQSPPASMYGSTGSLLRR----------V 50
A G +F G + P P LP P PQ PPA G +
Sbjct: 1347 AGGHPQFAPHGRHPLHQPTSP---LPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAA 1403
Query: 51 AGPG--PRGRELGRVTAPCTPLRG--------------PPSPRVAPSPWAPSSPTG---- 90
GPG P G P +PL PPSP SP P+SP G
Sbjct: 1404 GGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHA 1463
Query: 91 QPPPG 95
PPG
Sbjct: 1464 SGPPG 1468
>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
exchange factor 1 [Homo sapiens]
Length = 1859
Score = 101 bits (251), Expect = 4e-21
Identities = 72/238 (30%), Positives = 122/238 (51%), Gaps = 28/238 (11%)
Query: 496 GREPP----SPCHS-EDSLGLGA-APLGSEPP-LSQLVSDSDS--ELDSTERLALGSTDT 546
GR PP S C E+++ GA +PP S L+ D E+ + ++L + T+
Sbjct: 650 GRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQ 709
Query: 547 LSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLK---------- 596
+ K ++ Q +D +VA+ L +N K + GE++
Sbjct: 710 FNQKPKKGIQFLQEKGLLTIPMDN---TEVAQWLRENPRLDKKMIGEFVSDRKNIDLLES 766
Query: 597 ---FFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTL 653
F F G+ LD+ALR++L+ L GE +R+L F++R+ CN ++ D +L
Sbjct: 767 FVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACFSL 826
Query: 654 TCALMLLNTDLHGHNIGKR---MTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKL 708
A+++LNTD H HN+ K+ MT +F NL+G+N G DF +++L+ +Y +IKNE++
Sbjct: 827 AYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEI 884
>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
Length = 759
Score = 101 bits (251), Expect = 4e-21
Identities = 96/313 (30%), Positives = 137/313 (43%), Gaps = 54/313 (17%)
Query: 443 ELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEAR-AKLAPGREPPS 501
E P P R D A A ++ S AADG + EEEE E A++ G E +
Sbjct: 233 EAPEAPAVGREDASAEDSCA----EAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEA 288
Query: 502 ---PCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAA 558
S S +A GSE S + + S R + + K+ +
Sbjct: 289 GDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASC----KSPTLST 344
Query: 559 QRLAKRLYRLD------------------GF---RKADVARHLGKNNDFSKLVAGEYL-- 595
L KRLYR+ GF VA L + S+ + GE+L
Sbjct: 345 DTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGN 404
Query: 596 --KFFV------------FTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNP 641
K F F+ M LD+ALR F + + GE Q+ ER++ FSQRY CNP
Sbjct: 405 SKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNP 464
Query: 642 EALS---SEDGAHTLTCALMLLNTDLHGHNI--GKRMTCGDFIGNLEGLNDGGDFPRELL 696
E + + D L A++LLNTD++ NI ++M DFI NL G++DG D PREL+
Sbjct: 465 EVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELV 524
Query: 697 KALYSSIKNEKLQ 709
+Y I+ ++L+
Sbjct: 525 VGIYERIQQKELK 537
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 96.7 bits (239), Expect = 1e-19
Identities = 50/148 (33%), Positives = 81/148 (54%)
Query: 559 QRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELAL 618
Q +A+ LY+ +G K + +LG+ + + V ++ F + L QALR FL L
Sbjct: 94 QDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRL 153
Query: 619 MGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678
GE Q+ +R++ F+ RY CNP S D + L+ ++++LNT LH N+ R F
Sbjct: 154 PGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERF 213
Query: 679 IGNLEGLNDGGDFPRELLKALYSSIKNE 706
+ G+N+G D P + L+ L+ SIK+E
Sbjct: 214 VSMNRGINNGSDLPEDQLRNLFDSIKSE 241
>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
protein 1 [Homo sapiens]
Length = 1849
Score = 90.9 bits (224), Expect = 6e-18
Identities = 50/150 (33%), Positives = 81/150 (54%), Gaps = 2/150 (1%)
Query: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620
+A+ L++ + V LG N+ F+K V Y+ F+G ALR+FL+ L G
Sbjct: 733 IAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPG 792
Query: 621 ETQERERVLAHFSQRYFQCN--PEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678
E Q+ +R++ F+ RY +CN +S D A+ L ++++L TDLH + +MT +
Sbjct: 793 EAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 852
Query: 679 IGNLEGLNDGGDFPRELLKALYSSIKNEKL 708
I G+ND D P E L A+Y+ I +K+
Sbjct: 853 IKMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
Length = 1114
Score = 88.6 bits (218), Expect = 3e-17
Identities = 54/155 (34%), Positives = 84/155 (54%), Gaps = 6/155 (3%)
Query: 561 LAKRLYRLDGFRKADVARHLG-KNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALM 619
+A L + G + + LG + F++ V + F+ M LD+ALR F + +
Sbjct: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604
Query: 620 GETQERERVLAHFSQRYFQCNP---EALSSEDGAHTLTCALMLLNTDLHGHNI--GKRMT 674
GE Q+ ER++ FSQRY CNP + D L A++LLNTD++ N+ ++M
Sbjct: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664
Query: 675 CGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQ 709
DFI NL G++DG D PRE+L +Y I+ +L+
Sbjct: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK 699
>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
Length = 963
Score = 88.6 bits (218), Expect = 3e-17
Identities = 54/155 (34%), Positives = 84/155 (54%), Gaps = 6/155 (3%)
Query: 561 LAKRLYRLDGFRKADVARHLG-KNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALM 619
+A L + G + + LG + F++ V + F+ M LD+ALR F + +
Sbjct: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618
Query: 620 GETQERERVLAHFSQRYFQCNP---EALSSEDGAHTLTCALMLLNTDLHGHNI--GKRMT 674
GE Q+ ER++ FSQRY CNP + D L A++LLNTD++ N+ ++M
Sbjct: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678
Query: 675 CGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQ 709
DFI NL G++DG D PRE+L +Y I+ +L+
Sbjct: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK 713
>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
factor 2 [Homo sapiens]
Length = 1785
Score = 82.4 bits (202), Expect = 2e-15
Identities = 47/154 (30%), Positives = 79/154 (51%), Gaps = 2/154 (1%)
Query: 557 AAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKEL 616
+ + +A+ L++ + V LG + F+K V Y+ F ALR FL+
Sbjct: 674 SVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGF 733
Query: 617 ALMGETQERERVLAHFSQRYFQCNP--EALSSEDGAHTLTCALMLLNTDLHGHNIGKRMT 674
L GE Q+ +R++ F+ RY +CN +S D A+ L ++++L TDLH + +MT
Sbjct: 734 RLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMT 793
Query: 675 CGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKL 708
+I G+ND D P E L ++Y I+ +K+
Sbjct: 794 KEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKI 827
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 72.4 bits (176), Expect = 2e-12
Identities = 122/490 (24%), Positives = 158/490 (32%), Gaps = 104/490 (21%)
Query: 34 SPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCT-PLRGPPSPRVAPSPWAPSSPTGQP 92
SP A S G L+R P R L P + P R PS R P AP+ P+
Sbjct: 221 SPAARRRPSAGGGLQR-----PASRSLSSSATPLSSPARSGPSARGTPR--APAHPSQPK 273
Query: 93 PPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRP--TPALGPGSNRKLR 150
P G Q+ +RP V+PPR PALGP S+ L
Sbjct: 274 PKGLQA------------LRPPQ----------------VTPPRKDAAPALGPLSSSPLA 305
Query: 151 -------LEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERL 203
L++ LPA S+ + P APP A +LP+ PP +
Sbjct: 306 TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQA 365
Query: 204 ATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPS 263
T G P L ++ +S A +A P + A PP QAPPS
Sbjct: 366 TTSLGSPT----LQATHSFLPSPPLSPLATPPPQA-----------PPALALPPLQAPPS 410
Query: 264 PPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEG 323
PP +A L P + + + + P S+
Sbjct: 411 PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA 470
Query: 324 PPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLK 383
PP A PP P P P P + S A P + P
Sbjct: 471 PPSLAAPPLQVP-PSPPASPPM-------------------------SPSATPPPQAPPP 504
Query: 384 SPVPFLPGTSPSADGPDSFSCVFEAILESHRAK---GTSYTSLASL--EALASPGPTQSP 438
P L P P + + L S A ++ ASL LA+P P P
Sbjct: 505 LAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPP 564
Query: 439 FFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGRE 498
L PP+P P AP P P G ++ GP LAPG
Sbjct: 565 VLAAPLLQVPPSPPASPTLQAPRRP--PTPGPDTSVSGP----------RLTLALAPG-P 611
Query: 499 PPSPCHSEDS 508
PP P S S
Sbjct: 612 PPPPSRSPSS 621
Score = 57.4 bits (137), Expect = 7e-08
Identities = 112/463 (24%), Positives = 155/463 (33%), Gaps = 83/463 (17%)
Query: 81 SPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGG---LSRSWDLGGVSPPRP 137
+P P SP PP V A++R L A G R+ +GG + P
Sbjct: 26 TPRPPGSPRPPPP------------VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPES 73
Query: 138 TPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPP----------QVGADG 187
P GP + S P + G P ++N GP + P +G G
Sbjct: 74 APRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKG 133
Query: 188 LYSSLPNGLG-----GPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEF 242
L S + P+R A G DT G T +P + R A +
Sbjct: 134 LRISAEETVARGKATEAPKRSALSAGARRDT----SGPTPGTPSPAMARRSRAAGTEVGL 189
Query: 243 FYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDID 302
+P A P PP G R+ +V A+++S T+ R
Sbjct: 190 -----------PRPAPSARPRPPTEGPRK----SVSSASEHSTTEPSPAARRRPSAGGGL 234
Query: 303 EVLAEREEADSAIE-SQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEE 361
+ A R + SA S P+ GP P AP P P +A
Sbjct: 235 QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL-----------QALRPP 283
Query: 362 DVDDEVFEASEGARPGSRMPLKSPVPF------LPGTSPSADGPDSFSCVFEAILESHRA 415
V +A+ P S PL +P P P T P+ S +C L
Sbjct: 284 QVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPP 343
Query: 416 KGTSYTSLASLEALASPGPTQ------SPFF--TFELPPQPP-APRPDPPAPAP----LA 462
++ SL +L + + P+Q SP T P PP +P PP AP L
Sbjct: 344 SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP 403
Query: 463 PLE-PDSGTSSAADGPWTQRGEEEEAEARAKL--APGREPPSP 502
PL+ P S +S P + L AP PPSP
Sbjct: 404 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 446
Score = 35.4 bits (80), Expect = 0.28
Identities = 92/359 (25%), Positives = 115/359 (32%), Gaps = 69/359 (19%)
Query: 15 AISPPRCPRRW-LPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGP 73
A PP+ P LP P SPPAS S L + P + + AP +P P
Sbjct: 390 ATPPPQAPPALALPPLQAPPSPPAS---PPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 446
Query: 74 P---------SPRVAPSPWAPS-------SPTGQPPPGAQSSVVIFRFVEKASVRPLNGL 117
P SP V+PS PS +P Q PP +S + S P
Sbjct: 447 PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-----SPSATPPPQA 501
Query: 118 PAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGP 177
P P L+ PP+ PAL L+A S P G + S +L P
Sbjct: 502 PPP--LAAPPLQLAKPPPQAPPALATPP-----LQALPSPPASFPGQAPFSPSASLPMSP 554
Query: 178 PAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIAR 237
A P A PP A L P T +PR +
Sbjct: 555 LATPPPQA-------------PPVLAAPLLQVPPSP---PASPTLQAPRRPPTPGP---- 594
Query: 238 AKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVP--LRC 295
D SG + P PP SR S G + + P LR
Sbjct: 595 ----------DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG 644
Query: 296 YRETDIDEVLAEREEADSAIESQPS--SEGP-PGTAYPPAPRPGPLPGPHPSLGSGNED 351
Y A P+ S GP P A+ AP PLP P P+ G G+ D
Sbjct: 645 YDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAP-GAPLPWP-PATGPGSAD 701
Score = 30.4 bits (67), Expect = 8.9
Identities = 47/173 (27%), Positives = 56/173 (32%), Gaps = 34/173 (19%)
Query: 17 SPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPP-- 74
SPP P P P P S+ G +L P P R +P + L GP
Sbjct: 576 SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR------SPSSTLSGPDLA 629
Query: 75 --SPRVAPSP----WAPSSPTG----QPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLS 124
S +P S P G PPP A+ + + PL APG
Sbjct: 630 GHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPG--- 686
Query: 125 RSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGP 177
+P PA GPGS L T P SA P L GP
Sbjct: 687 --------APLPWPPATGPGSADGLCTIYETEGP-----ESATPAPGALDPGP 726
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 70.5 bits (171), Expect = 8e-12
Identities = 113/463 (24%), Positives = 160/463 (34%), Gaps = 110/463 (23%)
Query: 30 PVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPPSPR---VAPSP-WAP 85
P P+ P + + S +A P P+G AP TP PPSP+ PSP AP
Sbjct: 1143 PPPKGAPTTPAATPPSPKGGLATPPPKG-------APTTPAATPPSPKGGLATPSPKGAP 1195
Query: 86 SSPTGQPPPGAQSSVVIFRFVEKASVRPLNGL--PAPGGLSRSWDLGGVSPPRPTPALGP 143
++P PP P GL P+P G + +PP P L
Sbjct: 1196 TTPAATPP------------------SPKGGLATPSPKGAPTT---PAATPPSPKGGLAT 1234
Query: 144 GSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERL 203
S + + + P P +GG A P + G P PP SL GL PP +
Sbjct: 1235 PSPKGAPTTPAATPPSP-KGGPATPPPK----GAPTPPAATP----PSLKGGLATPPHKG 1285
Query: 204 A---TLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQA 260
A + P+ G G S P+ + + P S PP +
Sbjct: 1286 APNPAVVTPPSPKG----GPATSPPKGAPTPPAATPPS----------PKGSPGTPPPKG 1331
Query: 261 PPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPS 320
P+PP V G A S T P +E + + PS
Sbjct: 1332 APTPPAVTPPSPKGTPTLPATTPSSKGGPTTP--------------SSKEGPTPPAATPS 1377
Query: 321 SEGPPGTAYPPAPRPGP-LPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSR 379
+G P PP+P+ GP +P P + D + + + A+ R G+
Sbjct: 1378 HKGGPAMT-PPSPKRGPAIPSP----------KGDPTSPAVIPLSPKKAPATPVTREGAA 1426
Query: 380 MPLK--------SPVPF--LPGTS--------PSADGPDSFSCVFEAILESHRAKGTSYT 421
P K +PV P TS PS+ G + V + A T
Sbjct: 1427 TPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVAT 1486
Query: 422 SLASLEALASPGPTQSPFFTFELPPQP------PAPRPDPPAP 458
S + +A A+P P +P +P P P+ R DP AP
Sbjct: 1487 SSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAP 1529
Score = 65.9 bits (159), Expect = 2e-10
Identities = 124/508 (24%), Positives = 162/508 (31%), Gaps = 119/508 (23%)
Query: 27 PEGPVPQSPPA-SMYGSTGSLLRRV-------AGPGPRGRELGRVTAPCTPLRGP--PSP 76
P P P+ PA SM S+ R A P P+G P +P GP PSP
Sbjct: 900 PATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSP 959
Query: 77 RVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP-GGLSRSWDLGGVSPP 135
+ AP+P A + P+ + P S + A P P+P GG + G +PP
Sbjct: 960 KWAPTPPAATPPSPKGGPATPSP-------KGAPTPPAATPPSPKGGPATPSPKGAPTPP 1012
Query: 136 RPTPALGPGSNRKLRLEASTSDPLPARGGS--ALPGSRNLVHGPPAPPQVGADGLYSSLP 193
TP GS S P A S P + L G P P ++LP
Sbjct: 1013 AVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPA-------ATLP 1065
Query: 194 NGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSG 253
+ GGP +L G P T SP+ G P G
Sbjct: 1066 SPKGGPAT--PSLKGAPTPPAA-----TPPSPKG-----------------GPATPSPKG 1101
Query: 254 AK-PPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEAD 312
A PP PPSP G G+A T T P +
Sbjct: 1102 APMPPAATPPSPKG-------GLATPPHKGAPTTPAATPP------------------SP 1136
Query: 313 SAIESQPSSEGPPGT--AYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEA 370
+ P +G P T A PP+P+ G P + GG +
Sbjct: 1137 KGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPT 1196
Query: 371 SEGARPGS-RMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEAL 429
+ A P S + L +P P T+P+A P KG L
Sbjct: 1197 TPAATPPSPKGGLATPSPKGAPTTPAATPPSP--------------KG----------GL 1232
Query: 430 ASPGPTQSPFFTFELPPQP------PAPR--PDPPAPAP-------LAPLEPDSGTSSAA 474
A+P P +P PP P P P+ P PPA P P + +
Sbjct: 1233 ATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVV 1292
Query: 475 DGPWTQRGEEEEAEARAKLAPGREPPSP 502
P + G A P PPSP
Sbjct: 1293 TPPSPKGGPATSPPKGAPTPPAATPPSP 1320
Score = 63.9 bits (154), Expect = 7e-10
Identities = 119/504 (23%), Positives = 161/504 (31%), Gaps = 74/504 (14%)
Query: 30 PVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPPSPR---VAPSP-WAP 85
P P+ P + + S +A P P+G AP TP PPSP+ PSP AP
Sbjct: 1166 PPPKGAPTTPAATPPSPKGGLATPSPKG-------APTTPAATPPSPKGGLATPSPKGAP 1218
Query: 86 SSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP-GGLSRSWDLGGVSPPRPTP----- 139
++P PP + + + A P P+P GG + G +PP TP
Sbjct: 1219 TTPAATPP--SPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKG 1276
Query: 140 ALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGP 199
L ++ A + P P +GG A + P A P + P G P
Sbjct: 1277 GLATPPHKGAPNPAVVTPPSP-KGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTP 1335
Query: 200 PERLATLFGG----PADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAK 255
P G PA T G T S +E + K P A
Sbjct: 1336 PAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAI 1395
Query: 256 PPEQAPPSPPGV---GSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEAD 312
P + P+ P V ++ V R + + D P T + A A
Sbjct: 1396 PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAV---TPVSLKKAPATSAP 1452
Query: 313 SAIESQPSSEG--------PPGTAYPPAPR--------------PGPLPGPH-------- 342
+ PSS+G PP PPAP+ P P+ P
Sbjct: 1453 KGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSS 1512
Query: 343 ----PSLGSGNEDEDDDEAGGEEDVDDEVFEASEG-ARPGSRMPLKSPVPFLPGTSPSAD 397
P+ S D A E P +P P +P +
Sbjct: 1513 PKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPA 1572
Query: 398 GPDSFSCVFEAILESHRAKGT-SYTSLASLEALASPGPTQSPFFTFELPP--QPPAPRPD 454
P S + KG S L A+ SP P ++P PP PP+P
Sbjct: 1573 TPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAP-----TPPAVTPPSPEKG 1627
Query: 455 PPAPAPL-APLEPDSGTSSAADGP 477
P PAP P P SS D P
Sbjct: 1628 PATPAPKGTPTSPPVTPSSLKDSP 1651
Score = 62.4 bits (150), Expect = 2e-09
Identities = 124/559 (22%), Positives = 183/559 (32%), Gaps = 96/559 (17%)
Query: 15 AISPPRCPRR---------------WLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRE 59
A SP CP +L + P P S + AGP
Sbjct: 764 ASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDT---P 820
Query: 60 LGRVTAPCTPLRGPPSPRVA-------PSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVR 112
+G +++P +P+ P + SP SPT P GA + + K
Sbjct: 821 IGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTL 880
Query: 113 PLNGLPAPGGLSRSWDLGGVSPPRP--TPALGPGSNRKLRLEAS---------------- 154
P P P ++ + G + P P PAL S+ + A+
Sbjct: 881 PPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAP 940
Query: 155 ---TSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERL-ATLFGGP 210
+ P +GG A P + P A P G + P G PP + GGP
Sbjct: 941 TPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGP 1000
Query: 211 ADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAP---PSPPGV 267
A +P V+ + + + A F G+ PP++ P+ +P P P G
Sbjct: 1001 ATPSPKGA----PTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGA 1056
Query: 268 GSRQGSGV--AVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGP- 324
+ + + G A S T P A + + PS +G
Sbjct: 1057 PTTPAATLPSPKGGPATPSLKGAPTPP-------------AATPPSPKGGPATPSPKGAP 1103
Query: 325 -PGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGS-RMPL 382
P A PP+P+ G PH + GG + + A P S + L
Sbjct: 1104 MPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL 1163
Query: 383 KSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEA----LASPGPTQSP 438
+P P T+P+A P + L + KG T A+ + LA+P P +P
Sbjct: 1164 ATPPPKGAPTTPAATPPSP-----KGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAP 1218
Query: 439 FFTFELPPQP------PAPRPDPPAPA---------PLAPLEPDSGTSSAADGPWTQRGE 483
PP P P+P+ P PA P P + T AA P + G
Sbjct: 1219 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGL 1278
Query: 484 EEEAEARAKLAPGREPPSP 502
A PPSP
Sbjct: 1279 ATPPHKGAPNPAVVTPPSP 1297
Score = 49.7 bits (117), Expect = 1e-05
Identities = 115/523 (21%), Positives = 172/523 (32%), Gaps = 67/523 (12%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPPS--PRVAPSPWA 84
P P P+ P + SL +A P +G V P +P GP + P+ AP+P A
Sbjct: 1255 PATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPA 1314
Query: 85 --PSSPTGQP----PPGAQSSVVIFRFVEKAS-VRPLNGLPAPGGLSRSWDLGGVSPPRP 137
P SP G P P GA + + K + P + GG + G +PP
Sbjct: 1315 ATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAA 1374
Query: 138 TPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGP----------PAPPQVGADG 187
TP+ G + + P P RG A+P + P PA P V +G
Sbjct: 1375 TPSHKGGP--------AMTPPSPKRG-PAIPSPKGDPTSPAVIPLSPKKAPATP-VTREG 1424
Query: 188 LYSSLPNGLGGPPERLATLF---------GGPADTGFLNQGD------TWSSPREVSSHA 232
+ L P +L GGPA ++GD T SP+E +
Sbjct: 1425 AATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPS--SKGDPTLPAVTPPSPKEPPAPK 1482
Query: 233 QRIARAKWEFFYGSLDPPSSGAKPPEQAPPSP---PGVGSRQGSGVAVGRAAKYSETDLD 289
Q +A + + P P P SP P S + +A +T
Sbjct: 1483 Q-VATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPAT 1541
Query: 290 TVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGN 349
P + ++ A + P++ + PPA P G
Sbjct: 1542 LAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLI 1601
Query: 350 EDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPV--PFLPGT-SPSADGPDSFSCVF 406
+ E V S P + P +P P P + S P S +C
Sbjct: 1602 PPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKM 1661
Query: 407 EAIL-ESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPR---------PDPP 456
A + ++ + A E L +P P +P T P + PDP
Sbjct: 1662 GATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPS 1721
Query: 457 AP----APLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAP 495
A PL+ + P D T +G++ + LAP
Sbjct: 1722 AKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAP 1764
Score = 45.8 bits (107), Expect = 2e-04
Identities = 114/506 (22%), Positives = 165/506 (32%), Gaps = 94/506 (18%)
Query: 30 PVPQSPPASMYGSTGSLLRRV-AGPGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSP 88
P P+ PPA +T S ++ A P P G P +P P +P P AP++
Sbjct: 1473 PSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTAT 1532
Query: 89 T---GQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRS-WDLGGVSPPRPTPAL--G 142
P A +I + S + +P P + SPP TP+ G
Sbjct: 1533 LLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKG 1592
Query: 143 PGSNRKLRLEASTSDPLPARG-------------GSALPGSRNLVHGPPAPPQVGADGLY 189
S ++L + + + P P G A P + PP P D
Sbjct: 1593 APSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPT 1652
Query: 190 S--SLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSL 247
S S+ +G + + G PA G + +P S+ K G
Sbjct: 1653 SPASVTCKMGATVPQASK--GLPAKKGPTALKEVLVAPAPESTPIITAPTRK-----GPQ 1705
Query: 248 DPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAE 307
SS PP PS A S+ L TV +L
Sbjct: 1706 TKKSSATSPPICPDPS----------------AKNGSKGPLSTVAPA--------PLLPV 1741
Query: 308 REEADSAIESQPSSEGPPGTAYPPAPRPG-PLPGPHPSLGSGNEDEDDDEAGGEEDVDDE 366
++++ + + +S P G PP + PL A E V +
Sbjct: 1742 QKDSSKTAKGKDASHSPKGPLAPPESKASTPLT-----------------AAAFEKVLPK 1784
Query: 367 VFEASEGARPGSRMPLK---SPVPFLPGTS---PSADGPDSFSCVFEAILESHR-----A 415
AS A P + L SPVP LP PS+ G +LES A
Sbjct: 1785 PESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPG---------LVLESPSKPLAPA 1835
Query: 416 KGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAAD 475
L E ++ P QS P P P P A P+ SGT S +D
Sbjct: 1836 DEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSD 1895
Query: 476 GPWTQRGEEEEAEA---RAKLAPGRE 498
+ E++ +A +A+LA E
Sbjct: 1896 ESVPELEEQDSTQATTQQAQLAAAAE 1921
Score = 40.0 bits (92), Expect = 0.011
Identities = 63/269 (23%), Positives = 90/269 (33%), Gaps = 26/269 (9%)
Query: 257 PEQAP-PSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAI 315
P+ P PS P G+ G+ G + + + + P C E A + + +
Sbjct: 731 PKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYL 790
Query: 316 ESQPSSEG---PPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAG----------GEED 362
PS G P T PP + GP +G+ + EA G +D
Sbjct: 791 ADSPSPLGVSVSPQTKRPPTKKGSA--GPDTPIGNLSSPVSPVEASFLPENSLSFQGSKD 848
Query: 363 VDDEVFEASEGARPGSRMPLKSPVPFLPG--TSPSADGPDS------FSCVFEAILESHR 414
+ + G+ P + P P T P + P F A +
Sbjct: 849 SPATTHSPTPPSPKGAPTP-SAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQ 907
Query: 415 AKGTSYTSLASLEALASPGPTQSPFFTFEL-PPQPPAPRPDPPAPAPLAPLEPDSGTSSA 473
A S TS + +A A+P P P P PPA P P P P + T A
Sbjct: 908 APALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPA 967
Query: 474 ADGPWTQRGEEEEAEARAKLAPGREPPSP 502
A P + G + A P PPSP
Sbjct: 968 ATPPSPKGGPATPSPKGAPTPPAATPPSP 996
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 68.6 bits (166), Expect = 3e-11
Identities = 118/496 (23%), Positives = 156/496 (31%), Gaps = 86/496 (17%)
Query: 29 GPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPPSP--------RVAP 80
GP P +P +M + + V P P P P GP P
Sbjct: 157 GPTPGTPSPAMARRSRAAGTEVGLPRPAPS-----ARPRPPTEGPRKSVSSASEHSTTEP 211
Query: 81 SPWA---PSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRP 137
SP A PS+ G P ++S +S PL+ G +R P +P
Sbjct: 212 SPAARRRPSAGGGLQRPASRSL--------SSSATPLSSPARSGPSARGTPRAPAHPSQP 263
Query: 138 TPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLG 197
P G + R ++ D PA G L S P APP A +LP+
Sbjct: 264 KPK-GLQALRPPQVTPPRKDAAPALG--PLSSSPLATPSPSAPPSPSAPPSLQTLPSPPA 320
Query: 198 GPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPP 257
PP + T G P L ++ +S A +A P + A PP
Sbjct: 321 TPPSQATTSLGSPT----LQATHSFLPSPPLSPLATPPPQA-----------PPALALPP 365
Query: 258 EQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIES 317
QAPPSPP +A L P + + + +
Sbjct: 366 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA 425
Query: 318 QPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPG 377
P S+ PP A PP P P P P + S A P
Sbjct: 426 TPPSQAPPSLAAPPLQVP-PSPPASPPM-------------------------SPSATPP 459
Query: 378 SRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAK---GTSYTSLASL--EALASP 432
+ P P L P P + + L S A ++ ASL LA+P
Sbjct: 460 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 519
Query: 433 GPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAK 492
P P L PP+P P AP P P G ++ GP
Sbjct: 520 PPQAPPVLAAPLLQVPPSPPASPTLQAPRRP--PTPGPDTSVSGP----------RLTLA 567
Query: 493 LAPGREPPSPCHSEDS 508
LAPG PP P S S
Sbjct: 568 LAPG-PPPPPSRSPSS 582
Score = 35.4 bits (80), Expect = 0.28
Identities = 92/359 (25%), Positives = 115/359 (32%), Gaps = 69/359 (19%)
Query: 15 AISPPRCPRRW-LPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGP 73
A PP+ P LP P SPPAS S L + P + + AP +P P
Sbjct: 351 ATPPPQAPPALALPPLQAPPSPPAS---PPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 407
Query: 74 P---------SPRVAPSPWAPS-------SPTGQPPPGAQSSVVIFRFVEKASVRPLNGL 117
P SP V+PS PS +P Q PP +S + S P
Sbjct: 408 PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM-----SPSATPPPQA 462
Query: 118 PAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGP 177
P P L+ PP+ PAL L+A S P G + S +L P
Sbjct: 463 PPP--LAAPPLQLAKPPPQAPPALATPP-----LQALPSPPASFPGQAPFSPSASLPMSP 515
Query: 178 PAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIAR 237
A P A PP A L P T +PR +
Sbjct: 516 LATPPPQA-------------PPVLAAPLLQVPPSP---PASPTLQAPRRPPTPGP---- 555
Query: 238 AKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVP--LRC 295
D SG + P PP SR S G + + P LR
Sbjct: 556 ----------DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG 605
Query: 296 YRETDIDEVLAEREEADSAIESQPS--SEGP-PGTAYPPAPRPGPLPGPHPSLGSGNED 351
Y A P+ S GP P A+ AP PLP P P+ G G+ D
Sbjct: 606 YDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAP-GAPLPWP-PATGPGSAD 662
Score = 30.4 bits (67), Expect = 8.9
Identities = 47/173 (27%), Positives = 56/173 (32%), Gaps = 34/173 (19%)
Query: 17 SPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPP-- 74
SPP P P P P S+ G +L P P R +P + L GP
Sbjct: 537 SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR------SPSSTLSGPDLA 590
Query: 75 --SPRVAPSP----WAPSSPTG----QPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLS 124
S +P S P G PPP A+ + + PL APG
Sbjct: 591 GHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPG--- 647
Query: 125 RSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGP 177
+P PA GPGS L T P SA P L GP
Sbjct: 648 --------APLPWPPATGPGSADGLCTIYETEGP-----ESATPAPGALDPGP 687
>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
Length = 1499
Score = 67.8 bits (164), Expect = 5e-11
Identities = 132/554 (23%), Positives = 173/554 (31%), Gaps = 81/554 (14%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAG-PGPRGRELG------RVTAPCTPLRGPPSPRVA 79
P G + P + G G R +AG PGP+G G TA RG P P
Sbjct: 748 PSGTPGDTGPPGLQGMPGE--RGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGP 805
Query: 80 PSPWAPSSPTGQP-------PPGAQSSVVI------FRFVEKASVRPLNGLPA----PGG 122
P P P+ G+P PPG++ + V A + +G P PG
Sbjct: 806 PGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGE 865
Query: 123 LSRSWDLGGVSPPRPTPALGP-GSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPP 181
+ D G P + GP G N L+ P G + PGS V GPP P
Sbjct: 866 PGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPP-GATGFPGSAGRV-GPPGP- 922
Query: 182 QVGADGLYSSLPN-GLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW 240
GA G L G GPP L G P G + P
Sbjct: 923 -AGAPGPAGPLGEPGKEGPPG----LRGDPGSHGRVGDRGPAGPPGGP------------ 965
Query: 241 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD 300
G P +P PP P G ++G VG + E + +P
Sbjct: 966 ----GDKGDPGEDGQPGPDGPPGPAGTTGQRG---IVGMPGQRGERGMPGLPGPAGTPGK 1018
Query: 301 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGP-LPGPHPSLGSGNEDEDDDEAG- 358
+ A ++ P S GP G P P PG ++G + D AG
Sbjct: 1019 VGPTGATGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGL 1078
Query: 359 -------GEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILE 411
G +A + PGSR P+ P P GP +
Sbjct: 1079 PGSQGAPGTPGPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQGPRGDKGDHGDRGD 1138
Query: 412 SHRAKGTSYTSLASLEALASPGPTQSPF-----FTFELPPQPPAPRPDPPAPAPLAPLEP 466
+ +T L L P Q F PP P P P PL P+ P
Sbjct: 1139 RGQKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGP 1198
Query: 467 DSGTSSAAD-GPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLG--LGAAPLGSEPPLS 523
S + GP GE P P P H +LG +G PL
Sbjct: 1199 PGVRGSVGEAGPEGPPGEP---------GPPGPPGPPGHLTAALGDIMGHYDESMPDPLP 1249
Query: 524 QLVSDSDSELDSTE 537
+ D + D +
Sbjct: 1250 EFTEDQAAPDDKNK 1263
Score = 55.8 bits (133), Expect = 2e-07
Identities = 118/492 (23%), Positives = 154/492 (31%), Gaps = 94/492 (19%)
Query: 72 GPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGG 131
GP P+ +P P TG PPG Q R + G P P G D GG
Sbjct: 738 GPDGPKGSPGPSGTPGDTG--PPGLQGM---------PGERGIAGTPGPKG-----DRGG 781
Query: 132 VSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPA----PPQVGADG 187
+ G R L P G PG R LV GPP P G +G
Sbjct: 782 IGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLV-GPPGSRGNPGSRGENG 840
Query: 188 LYSSLPNGLGGP--PERLATLFGGPADTGFLNQGDTWS-SPREVSSHA-----QRIARAK 239
++ G GP P+ + G P + G +GD S P+ ++ + K
Sbjct: 841 PTGAV--GFAGPQGPDGQPGVKGEPGEPG--QKGDAGSPGPQGLAGSPGPHGPNGVPGLK 896
Query: 240 WEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRET 299
G+ PP + P PPG G +G K L P R
Sbjct: 897 GG--RGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVG 954
Query: 300 DIDEVL---AEREEADSAIESQPSSEGPPGTAYPPAPR-----PGP--------LPGPHP 343
D ++ D + QP +GPPG A R PG LPGP
Sbjct: 955 DRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAG 1014
Query: 344 SLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFS 403
+ G + G V PGS P+ P P P + G D
Sbjct: 1015 TPGKVGPTGATGDKGPPGPV----------GPPGSNGPVGEPGPEGPAGNDGTPGRDG-- 1062
Query: 404 CVFEAILESHRAKGTSYTSL-ASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLA 462
A+ E L S A +PGP + P R DP + P+
Sbjct: 1063 ----AVGERGDRGDPGPAGLPGSQGAPGTPGPVGA--------PGDAGQRGDPGSRGPIG 1110
Query: 463 PLEPDSGTSSAADGPWTQRGEEEEAEARAKLA-------------PGREPPSPCHSEDSL 509
P P GP RG++ + R PG PP P + S
Sbjct: 1111 P--PGRAGKRGLPGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPG--PPGPNGEQGSA 1166
Query: 510 GLGAAPLGSEPP 521
G+ P G P
Sbjct: 1167 GI-PGPFGPRGP 1177
Score = 48.1 bits (113), Expect = 4e-05
Identities = 94/380 (24%), Positives = 120/380 (31%), Gaps = 59/380 (15%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAGPGP---RGRELGRVTAPCTPLRGPPSPRVAPSPW 83
P GP + G G+ V PGP RG R L GP + P
Sbjct: 493 PIGPPGEEGKRGPRGDPGT----VGPPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPV 548
Query: 84 APSSPTG-QPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALG 142
S P G Q PG + R L G P G LG + P G
Sbjct: 549 GSSGPKGSQGDPGRPGEPGL------PGARGLTGNPGVQGPEGK--LGPLGAPGEDGRPG 600
Query: 143 PGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSL-PNGLGGPPE 201
P + +R + + +G S PG P Q GA G + P+G GPP
Sbjct: 601 PPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPG 660
Query: 202 RLATLF--GGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQ 259
G P TGF QG G PP G KP +Q
Sbjct: 661 LAGERGEQGPPGPTGF--QG-----------------------LPGPPGPPGEGGKPGDQ 695
Query: 260 APPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQP 319
P PG G G + E + +P ++ +A D + P
Sbjct: 696 GVPGDPGAVGPLGPRGERGNPGERGEPGITGLP--------GEKGMAGGHGPDGP-KGSP 746
Query: 320 SSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSR 379
G PG PP + +PG G+ D GG + E ++GAR G
Sbjct: 747 GPSGTPGDTGPPGLQ--GMPGERGIAGTPGPKGD---RGGIGEKGAEGTAGNDGAR-GLP 800
Query: 380 MPLKSPVPFLPGTSPSADGP 399
PL P P P GP
Sbjct: 801 GPLGPPGPAGPTGEKGEPGP 820
Score = 35.4 bits (80), Expect = 0.28
Identities = 41/177 (23%), Positives = 59/177 (33%), Gaps = 36/177 (20%)
Query: 313 SAIESQPSSEGPPGTAYPPAPR-PGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEAS 371
+ I +P GPPG+ P R P PGP G + +D E
Sbjct: 125 TGIRGRPGPAGPPGSQGPRGERGPKGRPGPR----------------GPQGIDGEPGVPG 168
Query: 372 EGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALAS 431
+ PG P PS GPD S F A + K + + +
Sbjct: 169 QPGAPG------------PPGHPSHPGPDGLSRPFSAQMAGLDEKSGLGSQVGLMPGSVG 216
Query: 432 PGPTQSP--FFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEE 486
P + P + P P +P P P+ P+ S +GP + GE+ E
Sbjct: 217 PVGPRGPQGLQGQQGGAGPTGPPGEPGDPGPMGPI-----GSRGPEGPPGKPGEDGE 268
Score = 35.0 bits (79), Expect = 0.36
Identities = 89/368 (24%), Positives = 114/368 (30%), Gaps = 84/368 (22%)
Query: 26 LPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAP 85
+P P P P + GS+G PG +G A T RGP P+ P
Sbjct: 361 MPGKPGPMGP-LGIPGSSGF----PGNPGMKGE------AGPTGARGPEGPQGQRGETGP 409
Query: 86 SSPTGQPP-PGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPP---RPTPAL 141
P G P PGA + +G P G + S G PP P +
Sbjct: 410 PGPVGSPGLPGAIGT---------------DGTPGAKGPTGSPGTSG--PPGSAGPPGSP 452
Query: 142 GP-GSNRKLRLEASTSDP-LPARGGSALPGSR---NLVHGPPAPPQVGADGLYSSLPN-G 195
GP GS + DP +P G A P + + GP PP G +G + G
Sbjct: 453 GPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPP--GEEGKRGPRGDPG 510
Query: 196 LGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAK 255
GPP + G P + GF D P+ + GS P S
Sbjct: 511 TVGPPGPVGER-GAPGNRGFPG-SDGLPGPKGAQGERGPV---------GSSGPKGSQGD 559
Query: 256 PPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAI 315
P P PG G+ G K PL
Sbjct: 560 PGRPGEPGLPGARGLTGNPGVQGPEGKLG-------PL--------------------GA 592
Query: 316 ESQPSSEGPPGT-AYPPAPRPGPLPGPHPSLGSGNEDEDDDEAG-----GEEDVDDEVFE 369
+ GPPG+ P LPGP S G + + AG G D EV
Sbjct: 593 PGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGP 652
Query: 370 ASEGARPG 377
+ PG
Sbjct: 653 SGPVGPPG 660
>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
Length = 1003
Score = 67.8 bits (164), Expect = 5e-11
Identities = 137/548 (25%), Positives = 177/548 (32%), Gaps = 135/548 (24%)
Query: 19 PRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAG------PGPR---------GRELGRV 63
P+ PRR P P P P S+ + +L V PGP G +
Sbjct: 381 PQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLP 440
Query: 64 TAPCTPLRGPPSPRVAPSPWAPSSPTGQ--PPPGAQSSVVIFRFVEKASVRPLNGLPAPG 121
P PP PR P P + +G PGA + AS P+ +P+P
Sbjct: 441 PPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPA-------ASKAPV--VPSPV 491
Query: 122 GLSRSWDLG-GVSPPRPTPALGPGSNRKLRLEASTSDPLPARG----GSALPGSRN---- 172
S S LG G P P P L G + P P +G G+ PG
Sbjct: 492 LQSPSEGLGMGAGPACPLPPLAGGE--------AFPFPSPEQGLALSGAGFPGMLGALPL 543
Query: 173 -LVHGPPAPPQVGADGLYSSLPNGLGGPP-ERLATLFGGPADTGFLNQGDTWSSPREVSS 230
L G P P + L+ L G G PP E L GGP +P E
Sbjct: 544 PLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPP---------LAPGEPEG 594
Query: 231 HAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPS------------PPGVGSRQGSGVAVG 278
+ +A L PP S PP APPS P G +GS G
Sbjct: 595 PSLLVASL--------LPPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAG 646
Query: 279 RAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPL 338
+ + L + + L A A P S PP AP+PGP
Sbjct: 647 GPSGEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGP- 705
Query: 339 PGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADG 398
P S+ + D PG+ K+P S S
Sbjct: 706 --PTSSVTTATTD------------------------PGASSLGKAP-------SNSGRP 732
Query: 399 PDSFSCVFEAILESHRAKGTSYT-SLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPA 457
P S + A L + TS +L SL L PGP S +L P AP P A
Sbjct: 733 PQLLSPLLGASLLGDLSSLTSSPGALPSL--LQPPGPLLSGQLGLQLLPGGGAPPPLSEA 790
Query: 458 PAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLG 517
+PLA L ++ P +P +PC +S P
Sbjct: 791 SSPLACL------------------------LQSLQIPPEQPEAPCLPPESPASALEPEP 826
Query: 518 SEPPLSQL 525
+ PPLS L
Sbjct: 827 ARPPLSAL 834
Score = 51.6 bits (122), Expect = 4e-06
Identities = 115/471 (24%), Positives = 156/471 (33%), Gaps = 127/471 (26%)
Query: 84 APSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGP 143
+P P+ +PP + PLNG PG L + VS PT A GP
Sbjct: 139 SPGPPSARPPCRVPPTT------------PLNG--GPGSLPP--EPPSVSQAFPTLA-GP 181
Query: 144 GSNRKLRLEASTSDPLPARGGSA---LPGSRNLVHGPPAPPQVGADG--------LYSSL 192
G RL +DP+P+ G S+ LP PP PP + + L SSL
Sbjct: 182 GGLFPPRL----ADPVPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSL 237
Query: 193 -PNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPS 251
P+ LG PP A+ P+D + D + P PPS
Sbjct: 238 VPSDLGSPPAPHASS-SPPSDPPLFHCSDALTPPPL---------------------PPS 275
Query: 252 SGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEA 311
+ P P S P V S + L V ++ A A
Sbjct: 276 NNL-PAHPGPASQPPVSS--------------ATMHLPLVLGPLGGAPTVEGPGAPPFLA 320
Query: 312 DSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEAS 371
S + + ++ +PP P P L G P + + S
Sbjct: 321 SSLLSAAAKAQ------HPPLPPPSTLQGRRPRAQAPSASH------------------S 356
Query: 372 EGARPGSRMPLKSPVPF--LPGTSPS----------ADGPDSFSCVFEAILESHRAKGTS 419
RP R P + P F L G P A P FS
Sbjct: 357 SSLRPSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLP--------EPSQPI 408
Query: 420 YTSLASLEALASPGPTQSP-FFTF-----ELPPQPPAPRPDPPAPA-PLAPLEPDSGTSS 472
S+ SL L +PGP+ S F LPP P PP P P+ P P + + S
Sbjct: 409 LPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGS 468
Query: 473 AADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLS 523
+ P A ++A + P SP + LG+GA P PPL+
Sbjct: 469 LSSVPGAPA---PPAASKAPVVPSPVLQSP---SEGLGMGAGPACPLPPLA 513
Score = 51.6 bits (122), Expect = 4e-06
Identities = 137/523 (26%), Positives = 175/523 (33%), Gaps = 154/523 (29%)
Query: 18 PPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPPSPR 77
PP P P G +P PP S +AGPG G R+ P P G SPR
Sbjct: 152 PPTTPLNGGP-GSLPPEPP-----SVSQAFPTLAGPG--GLFPPRLADP-VPSGGSSSPR 202
Query: 78 VAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRP 137
P AP SP PPP + + + G L S DLG SPP P
Sbjct: 203 FLPRGNAP-SPAPPPPPAISLNAPSYNW----------GAALRSSLVPS-DLG--SPPAP 248
Query: 138 TPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNL-VH-GPPAPPQVGADGLYSSLPNG 195
+ P S+ L + P P LP S NL H GP + P V + ++ L G
Sbjct: 249 HASSSPPSDPPLFHCSDALTPPP------LPPSNNLPAHPGPASQPPVSSATMHLPLVLG 302
Query: 196 -LGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSS-- 252
LGG P GP FL SS A+A+ + L PPS+
Sbjct: 303 PLGGAP-----TVEGPGAPPFL-----------ASSLLSAAAKAQ----HPPLPPPSTLQ 342
Query: 253 GAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEAD 312
G +P QAP +A +S + L R R + +L R
Sbjct: 343 GRRPRAQAP------------------SASHS-SSLRPSQRRPRRPPTVFRLLEGRG--- 380
Query: 313 SAIESQPSSEGPPGTAYPPAPRPGPLPGPH-------------PSLGSGNEDEDDDEAGG 359
P P A P P+P LP P P+ G + D + G
Sbjct: 381 ---PQTPRRSRPRAPA--PVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGS 435
Query: 360 EEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTS-------PSADGPDSFS---CVFEAI 409
+ + S G+ P R P++ P LPGT+ P A P + S V +
Sbjct: 436 DAHLPPPP-TLSSGSPPQPRHPIQ---PSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPV 491
Query: 410 LES-------HRAKGTSYTSLASLEALASPGPTQ-------------------------- 436
L+S LA EA P P Q
Sbjct: 492 LQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPP 551
Query: 437 -SPFFTFEL-----------PPQPPAPRPDPPAPAPLAPLEPD 467
SP L PP+P P P P P PLAP EP+
Sbjct: 552 PSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGP-PLAPGEPE 593
Score = 34.7 bits (78), Expect = 0.47
Identities = 40/148 (27%), Positives = 54/148 (36%), Gaps = 16/148 (10%)
Query: 381 PLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKG----TSYTSLASLEALASPGPTQ 436
PL P G P+++ + C +HR K T Y S+ + + +SPG
Sbjct: 78 PLAPVTPGGAGVGPASEEDMTKLC-------NHRRKAVAMATLYRSMETTCSHSSPGEGA 130
Query: 437 SPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPG 496
SP + P PP+ RP P P PL G S + P + A P
Sbjct: 131 SPQMFHTVSPGPPSARPPCRVP-PTTPLNGGPG-SLPPEPPSVSQAFPTLAGPGGLFPPR 188
Query: 497 REPPSPCHSEDS---LGLGAAPLGSEPP 521
P P S L G AP + PP
Sbjct: 189 LADPVPSGGSSSPRFLPRGNAPSPAPPP 216
>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 1487
Score = 63.2 bits (152), Expect = 1e-09
Identities = 108/404 (26%), Positives = 127/404 (31%), Gaps = 91/404 (22%)
Query: 28 EGPVPQSP-PASMYGSTGSLLRRVAGPGPRGRE--LGRVTAPCTP-LRGPPSPRVAPSPW 83
E P SP PA G+ G+ PG +G G AP P RGPP P+ A P
Sbjct: 394 EPGTPGSPGPAGASGNPGT----DGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPL 449
Query: 84 APSSPTGQPPPGAQSSVVIFRFVE--KASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPAL 141
P TG+P + F+ + K P APG G P +
Sbjct: 450 GPKGQTGEP------GIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPI 503
Query: 142 GPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPE 201
GP R A G PG L AP + G GL P G G P
Sbjct: 504 GPPGER------------GAPGNRGFPGQDGLAGPKGAPGERGPSGLAG--PKGANGDP- 548
Query: 202 RLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAP 261
G P + G P + G + P + + P
Sbjct: 549 ------GRPGEPGLPGARGLTGRPGDAGPQ-------------GKVGPSGAPGEDGRPGP 589
Query: 262 PSP------PGVGSRQGSGVAVGRAAKYSETDLDTVP-LRCYRETDIDEVLAEREEADSA 314
P P PGV G A G K E L P LR D
Sbjct: 590 PGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKD-------------- 635
Query: 315 IESQPSSEGPPGTAYPPAPR-----PGP-----LPGPHPSLGSGNEDEDDDEAGGEEDVD 364
+ + GPPG A P R PGP LPGP G G + D GE
Sbjct: 636 --GETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGK-PGDQGVPGEAGAP 692
Query: 365 DEVFEASEGARPGSR-----MPLKSPVPFLPGTSPSADGPDSFS 403
V E PG R L+ P LPGT P DGP S
Sbjct: 693 GLVGPRGERGFPGERGSPGAQGLQGP-RGLPGT-PGTDGPKGAS 734
Score = 49.7 bits (117), Expect = 1e-05
Identities = 87/352 (24%), Positives = 115/352 (32%), Gaps = 56/352 (15%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAG-PGPRGRELGRVTAP-CTPLRGPPSPRVAPSPWA 84
P+G Q + G G R G PGP G E G+ AP + RGPP P P
Sbjct: 973 PQGLAGQRGIVGLPGQRGE--RGFPGLPGPSG-EPGKQGAPGASGDRGPPGPVGPPGLTG 1029
Query: 85 PS-------SPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGG-------LSRSWDLG 130
P+ SP PPG + + + G P P G + D G
Sbjct: 1030 PAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRG 1089
Query: 131 GVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNL--------VHGPPAPPQ 182
P GP R ++ P +G + PG R L + G P PP
Sbjct: 1090 EAGAQGPMGPSGPAGARGIQ---GPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPG 1146
Query: 183 VGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEF 242
D S P G GP G P G + P + R R+
Sbjct: 1147 PSGDQGASG-PAGPSGPR-------GPPGPVGPSGKDGANGIPGPIGPPGPR-GRS---- 1193
Query: 243 FYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDID 302
G P P PP PPG G + +G K + PL+ R
Sbjct: 1194 --GETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPD------PLQYMRADQAA 1245
Query: 303 EVLAERE-EADSAIESQ----PSSEGPPGTAYPPAPRPGPLPGPHPSLGSGN 349
L + + E D+ ++S S P G+ PA L HP SG+
Sbjct: 1246 GGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGD 1297
Score = 49.3 bits (116), Expect = 2e-05
Identities = 106/472 (22%), Positives = 144/472 (30%), Gaps = 97/472 (20%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAG-PGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAP 85
P GP P + G G R AG GP+G + G V +GP
Sbjct: 736 PAGPPGAQGPPGLQGMPGE--RGAAGIAGPKG-DRGDVGE-----KGPEGAPGKDGGRGL 787
Query: 86 SSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGS 145
+ P G P P + EK V P + G + G PP P GP
Sbjct: 788 TGPIGPPGPAGANG-------EKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPG 840
Query: 146 NRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLAT 205
+G + PG + GP P G G P G+ GP
Sbjct: 841 ADGQPGAKGEQGEAGQKGDAGAPGPQ----GPSGAP--GPQG-----PTGVTGPKGARGA 889
Query: 206 LFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPP 265
G P TGF G + PP S P PP P
Sbjct: 890 Q-GPPGATGFPGAA-------------------------GRVGPPGSNGNPGPPGPPGPS 923
Query: 266 GVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPP 325
G +G+ G + E L + + +P +GP
Sbjct: 924 GKDGPKGARGDSGPPGRAGEPGL------------------QGPAGPPGEKGEPGDDGPS 965
Query: 326 GTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSP 385
G PP P+ L G +G + + G + + + GA P
Sbjct: 966 GAEGPPGPQ--GLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVG 1023
Query: 386 VPFLPGT--------SPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQS 437
P L G SP ADGP A ++ R + ++ A +PGP S
Sbjct: 1024 PPGLTGPAGEPGREGSPGADGPPGRDGA--AGVKGDRGE------TGAVGAPGAPGPPGS 1075
Query: 438 PFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSA--ADGPWTQRGEEEEA 487
P P P + D P+ P SG + A GP RG++ EA
Sbjct: 1076 PG-----PAGPTGKQGDRGEAGAQGPMGP-SGPAGARGIQGPQGPRGDKGEA 1121
Score = 42.7 bits (99), Expect = 0.002
Identities = 95/377 (25%), Positives = 117/377 (31%), Gaps = 83/377 (22%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAGPGPR---GRELGRVTAPCTPL--RGPPSPRVAPS 81
P P P PP G G+ ++AG G +LG + P P+ RGPP P AP
Sbjct: 164 PGPPGPPGPP----GLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPG 219
Query: 82 PWAPSSPTGQP-PPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPA 140
P G+P PG P+ PG + D G P
Sbjct: 220 PQGFQGNPGEPGEPGVSG--------------PMGPRGPPGPPGKPGDDGEAGKPGKAGE 265
Query: 141 LGPGSNRKLRLEASTSDPLPA----RGGSALPGSRNLVHGPPAPPQVGADGLYSSL---- 192
GP + R T LP RG L G++ P + G+ G S
Sbjct: 266 RGPPGPQGARGFPGTPG-LPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMG 324
Query: 193 PNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSL----D 248
P GL P ER T GPA D P + + A F G+ +
Sbjct: 325 PRGL--PGERGRT---GPAGAAGARGNDGQPGP---AGPPGPVGPAGGPGFPGAPGAKGE 376
Query: 249 PPSSGAKPPE--QAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLA 306
+GA+ PE Q P PG G A G TD
Sbjct: 377 AGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPG----TD------------------- 413
Query: 307 EREEADSAIESQPSSEGPPGTAYPPA-PRPGPLPGPHPSLGSGNEDEDDDEAG-----GE 360
I S G PG A P P P PGP + G E G GE
Sbjct: 414 -------GIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGE 466
Query: 361 EDVDDEVFEASEGARPG 377
+ E A PG
Sbjct: 467 QGPKGEPGPAGPQGAPG 483
Score = 42.4 bits (98), Expect = 0.002
Identities = 116/497 (23%), Positives = 150/497 (30%), Gaps = 106/497 (21%)
Query: 67 CTPLRGPPSPRVAPSPWAPSSPT------GQPPPGAQSSVVIFRFVEKASVRPLNGLPAP 120
C ++ SP + P PT GQP P Q E ++ + G P
Sbjct: 69 CEDVKDCLSPEIPFGECCPICPTDLATASGQPGPKGQKG-------EPGDIKDIVGPKGP 121
Query: 121 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP 180
G P P GP +R + E P G PG+ GPP P
Sbjct: 122 PG-----------PQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGN----PGPPGP 166
Query: 181 PQVGADGLYSSLPNGLGGP-PERLATLF---GGPADTGFLNQGDTWSSPREVSSHAQRIA 236
P G G P GLGG ++A F G A G + PR A
Sbjct: 167 P--GPPG-----PPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPG 219
Query: 237 RAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAK------YSETDLDT 290
++ G P + PP PPG G G+A +
Sbjct: 220 PQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPG 279
Query: 291 VP-------LRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGP----LP 339
P R Y D A+ E ++ + S G G+ P PR P
Sbjct: 280 TPGLPGVKGHRGYPGLD----GAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRT 335
Query: 340 GPHPSLGSGNEDEDDDEAGGEEDV---DDEVFEASEGAR-----PGSRMPLKSPVPFLPG 391
GP + G+ D AG V F + GA+ G+R P + P
Sbjct: 336 GPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEP 395
Query: 392 TSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAP 451
+P + GP S GT A A +PG +P F P P
Sbjct: 396 GTPGSPGPAGAS----------GNPGTDGIPGAKGSA-GAPGIAGAPGF--------PGP 436
Query: 452 RPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREP--------PSPC 503
R P PL GP Q GE A + + P EP P P
Sbjct: 437 RGPPGPQGATGPL-----------GPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPA 485
Query: 504 HSEDSLGLGAAPLGSEP 520
E G P G P
Sbjct: 486 GEEGKRGARGEPGGVGP 502
>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 1418
Score = 63.2 bits (152), Expect = 1e-09
Identities = 108/404 (26%), Positives = 127/404 (31%), Gaps = 91/404 (22%)
Query: 28 EGPVPQSP-PASMYGSTGSLLRRVAGPGPRGRE--LGRVTAPCTP-LRGPPSPRVAPSPW 83
E P SP PA G+ G+ PG +G G AP P RGPP P+ A P
Sbjct: 325 EPGTPGSPGPAGASGNPGT----DGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPL 380
Query: 84 APSSPTGQPPPGAQSSVVIFRFVE--KASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPAL 141
P TG+P + F+ + K P APG G P +
Sbjct: 381 GPKGQTGEP------GIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPI 434
Query: 142 GPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPE 201
GP R A G PG L AP + G GL P G G P
Sbjct: 435 GPPGER------------GAPGNRGFPGQDGLAGPKGAPGERGPSGLAG--PKGANGDP- 479
Query: 202 RLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAP 261
G P + G P + G + P + + P
Sbjct: 480 ------GRPGEPGLPGARGLTGRPGDAGPQ-------------GKVGPSGAPGEDGRPGP 520
Query: 262 PSP------PGVGSRQGSGVAVGRAAKYSETDLDTVP-LRCYRETDIDEVLAEREEADSA 314
P P PGV G A G K E L P LR D
Sbjct: 521 PGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKD-------------- 566
Query: 315 IESQPSSEGPPGTAYPPAPR-----PGP-----LPGPHPSLGSGNEDEDDDEAGGEEDVD 364
+ + GPPG A P R PGP LPGP G G + D GE
Sbjct: 567 --GETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGK-PGDQGVPGEAGAP 623
Query: 365 DEVFEASEGARPGSR-----MPLKSPVPFLPGTSPSADGPDSFS 403
V E PG R L+ P LPGT P DGP S
Sbjct: 624 GLVGPRGERGFPGERGSPGAQGLQGP-RGLPGT-PGTDGPKGAS 665
Score = 49.7 bits (117), Expect = 1e-05
Identities = 87/352 (24%), Positives = 115/352 (32%), Gaps = 56/352 (15%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAG-PGPRGRELGRVTAP-CTPLRGPPSPRVAPSPWA 84
P+G Q + G G R G PGP G E G+ AP + RGPP P P
Sbjct: 904 PQGLAGQRGIVGLPGQRGE--RGFPGLPGPSG-EPGKQGAPGASGDRGPPGPVGPPGLTG 960
Query: 85 PS-------SPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGG-------LSRSWDLG 130
P+ SP PPG + + + G P P G + D G
Sbjct: 961 PAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRG 1020
Query: 131 GVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNL--------VHGPPAPPQ 182
P GP R ++ P +G + PG R L + G P PP
Sbjct: 1021 EAGAQGPMGPSGPAGARGIQ---GPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPG 1077
Query: 183 VGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEF 242
D S P G GP G P G + P + R R+
Sbjct: 1078 PSGDQGASG-PAGPSGPR-------GPPGPVGPSGKDGANGIPGPIGPPGPR-GRS---- 1124
Query: 243 FYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDID 302
G P P PP PPG G + +G K + PL+ R
Sbjct: 1125 --GETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPD------PLQYMRADQAA 1176
Query: 303 EVLAERE-EADSAIESQ----PSSEGPPGTAYPPAPRPGPLPGPHPSLGSGN 349
L + + E D+ ++S S P G+ PA L HP SG+
Sbjct: 1177 GGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGD 1228
Score = 49.3 bits (116), Expect = 2e-05
Identities = 106/472 (22%), Positives = 144/472 (30%), Gaps = 97/472 (20%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAG-PGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAP 85
P GP P + G G R AG GP+G + G V +GP
Sbjct: 667 PAGPPGAQGPPGLQGMPGE--RGAAGIAGPKG-DRGDVGE-----KGPEGAPGKDGGRGL 718
Query: 86 SSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGS 145
+ P G P P + EK V P + G + G PP P GP
Sbjct: 719 TGPIGPPGPAGANG-------EKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPG 771
Query: 146 NRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLAT 205
+G + PG + GP P G G P G+ GP
Sbjct: 772 ADGQPGAKGEQGEAGQKGDAGAPGPQ----GPSGAP--GPQG-----PTGVTGPKGARGA 820
Query: 206 LFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPP 265
G P TGF G + PP S P PP P
Sbjct: 821 Q-GPPGATGFPGAA-------------------------GRVGPPGSNGNPGPPGPPGPS 854
Query: 266 GVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPP 325
G +G+ G + E L + + +P +GP
Sbjct: 855 GKDGPKGARGDSGPPGRAGEPGL------------------QGPAGPPGEKGEPGDDGPS 896
Query: 326 GTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSP 385
G PP P+ L G +G + + G + + + GA P
Sbjct: 897 GAEGPPGPQ--GLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVG 954
Query: 386 VPFLPGT--------SPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQS 437
P L G SP ADGP A ++ R + ++ A +PGP S
Sbjct: 955 PPGLTGPAGEPGREGSPGADGPPGRDGA--AGVKGDRGE------TGAVGAPGAPGPPGS 1006
Query: 438 PFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSA--ADGPWTQRGEEEEA 487
P P P + D P+ P SG + A GP RG++ EA
Sbjct: 1007 PG-----PAGPTGKQGDRGEAGAQGPMGP-SGPAGARGIQGPQGPRGDKGEA 1052
Score = 42.7 bits (99), Expect = 0.002
Identities = 95/377 (25%), Positives = 117/377 (31%), Gaps = 83/377 (22%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAGPGPR---GRELGRVTAPCTPL--RGPPSPRVAPS 81
P P P PP G G+ ++AG G +LG + P P+ RGPP P AP
Sbjct: 95 PGPPGPPGPP----GLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPG 150
Query: 82 PWAPSSPTGQP-PPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPA 140
P G+P PG P+ PG + D G P
Sbjct: 151 PQGFQGNPGEPGEPGVSG--------------PMGPRGPPGPPGKPGDDGEAGKPGKAGE 196
Query: 141 LGPGSNRKLRLEASTSDPLPA----RGGSALPGSRNLVHGPPAPPQVGADGLYSSL---- 192
GP + R T LP RG L G++ P + G+ G S
Sbjct: 197 RGPPGPQGARGFPGTPG-LPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMG 255
Query: 193 PNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSL----D 248
P GL P ER T GPA D P + + A F G+ +
Sbjct: 256 PRGL--PGERGRT---GPAGAAGARGNDGQPGP---AGPPGPVGPAGGPGFPGAPGAKGE 307
Query: 249 PPSSGAKPPE--QAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLA 306
+GA+ PE Q P PG G A G TD
Sbjct: 308 AGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPG----TD------------------- 344
Query: 307 EREEADSAIESQPSSEGPPGTAYPPA-PRPGPLPGPHPSLGSGNEDEDDDEAG-----GE 360
I S G PG A P P P PGP + G E G GE
Sbjct: 345 -------GIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGE 397
Query: 361 EDVDDEVFEASEGARPG 377
+ E A PG
Sbjct: 398 QGPKGEPGPAGPQGAPG 414
Score = 37.7 bits (86), Expect = 0.056
Identities = 102/428 (23%), Positives = 130/428 (30%), Gaps = 82/428 (19%)
Query: 130 GGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLY 189
G P P GP +R + E P G PG+ GPP PP G G
Sbjct: 51 GPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGN----PGPPGPP--GPPG-- 102
Query: 190 SSLPNGLGGP-PERLATLF---GGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYG 245
P GLGG ++A F G A G + PR A ++ G
Sbjct: 103 ---PPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPG 159
Query: 246 SLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAK------YSETDLDTVP------- 292
P + PP PPG G G+A + P
Sbjct: 160 EPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKG 219
Query: 293 LRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGP----LPGPHPSLGSG 348
R Y D A+ E ++ + S G G+ P PR P GP + G+
Sbjct: 220 HRGYPGLD----GAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGAR 275
Query: 349 NEDEDDDEAGGEEDV---DDEVFEASEGAR-----PGSRMPLKSPVPFLPGTSPSADGPD 400
D AG V F + GA+ G+R P + P +P + GP
Sbjct: 276 GNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPA 335
Query: 401 SFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAP 460
S GT A A +PG +P F P PR P
Sbjct: 336 GAS----------GNPGTDGIPGAKGSA-GAPGIAGAPGF--------PGPRGPPGPQGA 376
Query: 461 LAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREP--------PSPCHSEDSLGLG 512
PL GP Q GE A + + P EP P P E G
Sbjct: 377 TGPL-----------GPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGAR 425
Query: 513 AAPLGSEP 520
P G P
Sbjct: 426 GEPGGVGP 433
>gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]
Length = 1838
Score = 62.4 bits (150), Expect = 2e-09
Identities = 133/527 (25%), Positives = 164/527 (31%), Gaps = 106/527 (20%)
Query: 29 GPVPQSPPASMYGSTGSLLRRVAG-PGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSS 87
GP Q P G G R + G PGP+G G A GPP R P P
Sbjct: 907 GPRGQRGPTGPRGERGP--RGITGKPGPKGNSGGDGPA------GPPGER---GPNGPQG 955
Query: 88 PTGQP----PPGAQSSVVIFRFVEKASVRPLNGLPA-PGGLSRSWDLGGVSPPRPTPALG 142
PTG P PPG +GLP PG + G PP P +G
Sbjct: 956 PTGFPGPKGPPGPPGK---------------DGLPGHPGQRGETGFQGKTGPPGPPGVVG 1000
Query: 143 P----GSNRKLRLEASTSDPLPARGGSALPG--SRNLVHGPPAPPQV-GADGLYSSLPNG 195
P G + P P G LPG + G P P + G DG P G
Sbjct: 1001 PQGPTGETGPMGERGHPGPPGPP-GEQGLPGLAGKEGTKGDPGPAGLPGKDG-----PPG 1054
Query: 196 LGG-PPERLATLFGGPADTGFL----NQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPP 250
L G P +R G P G L N+G P S +R G+ P
Sbjct: 1055 LRGFPGDR-----GLPGPVGALGLKGNEGPP-GPPGPAGSPGERGPA-------GAAGPI 1101
Query: 251 SSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRC------YRETDIDEV 304
+P Q PP P G G G A + +P + D E+
Sbjct: 1102 GIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEI 1161
Query: 305 LAEREEADSAIESQPSSEGPPGTAYPPAP--RPGPL-----PGPHPSLGSGNEDEDDDEA 357
E + +GPPG P P +PGP PGP G + D+
Sbjct: 1162 ---GEPGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPR 1218
Query: 358 G--------GEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVF--- 406
G G + + E E G P P P P +P ADGP
Sbjct: 1219 GFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNP 1278
Query: 407 EAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQ----PPAPRPDP------- 455
A+ E L PGP E P PP P+ P
Sbjct: 1279 GAVGEKGEPGEAGEPGLPG--EGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKG 1336
Query: 456 ---PAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREP 499
P P P P + DGP +G++ E P EP
Sbjct: 1337 SPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEP 1383
Score = 52.4 bits (124), Expect = 2e-06
Identities = 118/484 (24%), Positives = 150/484 (30%), Gaps = 106/484 (21%)
Query: 10 SEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRE--LGRVTAPC 67
S+GD P P P+GP+ Q P+ G PGPRG++ G+
Sbjct: 1169 SKGDKGEQGPPGPTG--PQGPIGQPGPSGADGE----------PGPRGQQGLFGQ----- 1211
Query: 68 TPLRGPPSPRVAPSPWAPSSPTGQP-PPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRS 126
+G PR P P P G P PPG + E V + PG S
Sbjct: 1212 ---KGDEGPRGFPGPPGPVGLQGLPGPPGEKG--------ETGDVGQMGPPGPPGPRGPS 1260
Query: 127 WDLGGVSPPRPTPALG-PGSNRKLRLEASTSDP-LPARGGSALP-GSRNL--------VH 175
G P P +G PG+ + +P LP GG P G R
Sbjct: 1261 GAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAA 1320
Query: 176 GPPAPPQVGADGLYSSLPNGLG-----GPPERL--ATLFGGPADTGFLNQGDTWSSPREV 228
GPP P D P +G GPP A G P D G + SP
Sbjct: 1321 GPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSP--- 1377
Query: 229 SSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDL 288
G P P ++ PP P G RQG A G A
Sbjct: 1378 ----------------GPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGK 1421
Query: 289 --DTVPLRCYRETDIDEVLA-EREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSL 345
P + D + + + P +GPPG PP LPG
Sbjct: 1422 TGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPG-----LPGLKGDS 1476
Query: 346 GSGNEDEDDDEAG-----GEE-DVDDEVFEASEGAR-PGSRMPLKSPV-PFLPGTSPSAD 397
G E G GE+ + D +G+ P + P P P P
Sbjct: 1477 GPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGPIGPPGPPGLP 1536
Query: 398 GPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPA 457
GP AKG+S + EA PG PP PP P +
Sbjct: 1537 GPPG----------PKGAKGSSGPTGPKGEA-GHPG-----------PPGPPGPPGEVIQ 1574
Query: 458 PAPL 461
P P+
Sbjct: 1575 PLPI 1578
Score = 45.1 bits (105), Expect = 3e-04
Identities = 119/508 (23%), Positives = 148/508 (29%), Gaps = 143/508 (28%)
Query: 32 PQSPPASMYGSTGSLLRRVAGPGPRGRE--LGRVTAPCTP-LRGPPSP---RVAPSPWAP 85
P PP G GS PG RG G + P P +GPP P + AP P
Sbjct: 1079 PPGPP----GPAGS-------PGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGAPGEKGP 1127
Query: 86 SSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGL----SRSWDLGGVSPPRPTPAL 141
P G+ G Q V GLP P G D G + P
Sbjct: 1128 QGPAGRD--GLQGPV---------------GLPGPAGPVGPPGEDGDKGEIGEP------ 1164
Query: 142 GPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSL----PNGLG 197
G ++ + E P +G PG G P P G GL+ P G
Sbjct: 1165 GQKGSKGDKGEQGPPGPTGPQGPIGQPGPSG-ADGEPGPR--GQQGLFGQKGDEGPRGFP 1221
Query: 198 GPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPP 257
GPP + L G P G +G+T G + PP P
Sbjct: 1222 GPPGPVG-LQGLPGPPG--EKGETGD--------------------VGQMGPPGP---PG 1255
Query: 258 EQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIES 317
+ P PG QG +G E +
Sbjct: 1256 PRGPSGAPGADGPQGPPGGIGNPGAVGE------------------------------KG 1285
Query: 318 QPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPG 377
+P G PG P G PGP G E AG + +G+
Sbjct: 1286 EPGEAGEPGL-----PGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGP 1340
Query: 378 SRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQS 437
P P PG + DGP KG PG T S
Sbjct: 1341 VGFPGDPGPPGEPGPA-GQDGPPG-------------DKGDD----------GEPGQTGS 1376
Query: 438 PFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAA--DGPWTQRGEEEEAEARAKLAP 495
P T E P P + PP PA + + G A +GP + G A K P
Sbjct: 1377 PGPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGP 1436
Query: 496 G--REPPSPCHSEDSLGLGAAPLGSEPP 521
R P P + GL +P PP
Sbjct: 1437 DGLRGIPGPVGEQ---GLPGSPGPDGPP 1461
Score = 44.3 bits (103), Expect = 6e-04
Identities = 105/459 (22%), Positives = 135/459 (29%), Gaps = 103/459 (22%)
Query: 29 GPVPQSPPASMYGSTGSLLRRVAGP----GPRGRE--LGRVTAPCTP----------LRG 72
GP + P G+ G+ + + GP GP G + LG+ P P G
Sbjct: 712 GPQGEPGPPGQQGNPGA--QGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEG 769
Query: 73 PPSPRVAPSPWAPSSPTGQP-PPGAQSSVVIFRFVEKASVRPLNGLPA-PGGLSRSWDLG 130
PP + P P P G P P G + + I + +G P G + D G
Sbjct: 770 PPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRG 829
Query: 131 GVSPPRPT-------------------PALGPGSNRKLRLEA-----STSDPLPARGGSA 166
+ PP P P PG KL + P + G
Sbjct: 830 EIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPG 889
Query: 167 LPGSRNLVHGPPAPPQVGADGLYSSL-PNGLGGPPERLATLFGGPADTGFLNQGDTWSSP 225
PG+ G P + G G P G GP + G P G P
Sbjct: 890 FPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGP----RGITGKPGPKGNSGGDGPAGPP 945
Query: 226 REVSSHAQRIARAKWEFFYGSLDPPSSGAKP-----PEQ----------APPSPPGVGSR 270
E + + F G PP K P Q PP PPGV
Sbjct: 946 GERGPNGPQGPTG----FPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGP 1001
Query: 271 QGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLA-EREEADSAIESQPSSEGPPGTAY 329
QG G + P E + + E + D P +GPPG
Sbjct: 1002 QGPTGETGPMGERGHPGPPGPP----GEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRG 1057
Query: 330 PPAPR--PGPL-----------PGPHPSLGSGNEDEDDDEAG-----------------G 359
P R PGP+ PGP GS E AG G
Sbjct: 1058 FPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAG 1117
Query: 360 EEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADG 398
E+ E R G + P+ P P P P DG
Sbjct: 1118 EKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDG 1156
Score = 42.4 bits (98), Expect = 0.002
Identities = 91/380 (23%), Positives = 119/380 (31%), Gaps = 99/380 (26%)
Query: 54 GPRGRELGR----VTAPCTPLRGPPSPRVA---PSPWAPSSPTGQP-------PPGAQSS 99
GPRG + + + P + GPP P P P PTGQ PPG
Sbjct: 447 GPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTMGPTGQVGDPGERGPPG---- 502
Query: 100 VVIFRFVEKASVRPLNGLPAPGG--LSRSWDLGGVSPPRPTPALGPG-SNRKLRLEASTS 156
+ + +GLP P G L + GG + GP S ++ + +A
Sbjct: 503 --------RPGLPGADGLPGPPGTMLMLPFRFGGGGD---AGSKGPMVSAQESQAQAILQ 551
Query: 157 DPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSL-------PNGLGGPPERLATLFGG 209
A G A P GP PP G+ GL P G+ GPP G
Sbjct: 552 QARLALRGPAGPMGLTGRPGPVGPP--GSGGLKGEPGDVGPQGPRGVQGPPGPA----GK 605
Query: 210 PADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGS 269
P G P + R ++ G P PP PPG
Sbjct: 606 PGRRGRAGSDGARGMPGQTGPKGDR----GFDGLAGLPGEKGHRGDPGPSGPPGPPGDDG 661
Query: 270 RQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAY 329
+G VG + +P G G
Sbjct: 662 ERGDDGEVG---------------------------------PRGLPGEPGPRGLLGPKG 688
Query: 330 PPAPRPGP--------LPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGA--RPGSR 379
PP P PGP PGP ++G E + G + + +GA PG +
Sbjct: 689 PPGP-PGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQG---NPGAQGLPGPQGAIGPPGEK 744
Query: 380 MPLKSPVPFLPGTSPSADGP 399
PL P LPG P ADGP
Sbjct: 745 GPLGK--PGLPG-MPGADGP 761
Score = 32.7 bits (73), Expect = 1.8
Identities = 88/354 (24%), Positives = 108/354 (30%), Gaps = 60/354 (16%)
Query: 54 GPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRP 113
GPRG L G P PR P P P G PPG + + K +V P
Sbjct: 670 GPRG------------LPGEPGPRGLLGPKGPPGPPG--PPGVTG--MDGQPGPKGNVGP 713
Query: 114 LNGLPAPGGLSRSWDLGGVSPPRPTPALGP----GSNRKLRLEAST-SDPLPARGGSALP 168
G P P G + + G P P A+GP G K L +D P G P
Sbjct: 714 -QGEPGPPG--QQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGP 770
Query: 169 GSRNLVHGPPAPP-QVGADGLYSSLPNGLGGPP--ERLATLFGGPADTGFLN-QGDTWSS 224
GPP P +G G P G+ G L G + GF +GD
Sbjct: 771 PGEKGGQGPPGPQGPIGYPG-----PRGVKGADGIRGLKGTKGEKGEDGFPGFKGD---- 821
Query: 225 PREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYS 284
+ R G + PP + + P G G G K
Sbjct: 822 ---MGIKGDR----------GEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLG 868
Query: 285 ETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPR--PGP----- 337
L P R + I + P GP G P PR GP
Sbjct: 869 VPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITG 928
Query: 338 LPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPG 391
PGP + G E G F +G PG P K +P PG
Sbjct: 929 KPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGP-PGP--PGKDGLPGHPG 979
>gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein [Homo
sapiens]
Length = 1650
Score = 61.2 bits (147), Expect = 5e-09
Identities = 123/477 (25%), Positives = 152/477 (31%), Gaps = 113/477 (23%)
Query: 33 QSPPASMYGSTGSLLRRVAGP-GPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSS---P 88
+S P G TG +R GP G G+ + T+ GPP R P P P+ P
Sbjct: 747 KSGPRGERGPTGPRGQR--GPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGP 804
Query: 89 TGQP-PPGAQSSVVIFRFVEKASVRPLNGLPA-PGGLSRSWDLGGVSPPRPTPALGP--- 143
G P PPG +GLP PG G PP P +GP
Sbjct: 805 KGPPGPPGK------------------DGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGA 846
Query: 144 -GSNRKLRLEASTSDPLPARGGSALPGS--RNLVHGPPAPPQV-GADGLYSSLPNGLGG- 198
G + P P G LPG+ + G P PP G DG P GL G
Sbjct: 847 AGETGPMGERGHPGPPGPP-GEQGLPGTAGKEGTKGDPGPPGAPGKDG-----PAGLRGF 900
Query: 199 PPER-LATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPP 257
P ER L GGP G N+G + P S +R A G + PP
Sbjct: 901 PGERGLPGTAGGPGLKG--NEGPS-GPPGPAGSPGERGAAGSG----GPIGPPG------ 947
Query: 258 EQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIES 317
P PPG +G
Sbjct: 948 RPGPQGPPGAAGEKGV-------------------------------------------- 963
Query: 318 QPSSEGPPG-TAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAG--GEEDVDDEVFEASEGA 374
P +GP G T P LPGP G ED D E G G++ E
Sbjct: 964 -PGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPG 1022
Query: 375 RPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGP 434
PG P+ P P A GP F A + L+ L PGP
Sbjct: 1023 PPGPIGPVGQPGAAGADGEPGARGPQGH---FGAKGDEGTRGFNGPPGPIGLQGL--PGP 1077
Query: 435 TQSPFFTFEL----PPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEA 487
+ T ++ PP PP PR P P G + GP ++GE E+
Sbjct: 1078 SGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNL--GPPGEKGEPGES 1132
Score = 56.6 bits (135), Expect = 1e-07
Identities = 119/473 (25%), Positives = 150/473 (31%), Gaps = 123/473 (26%)
Query: 27 PEGPVPQSPPASMYGSTGS--LLRRVAGPGPRGRELGRVTAPCTPLRGPPSPRVAPSPWA 84
P G + PA + G G L GPG +G E + P P G P R A
Sbjct: 885 PPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNE--GPSGPPGPA-GSPGERGAAGSGG 941
Query: 85 PSSPTGQP----PPGAQSSVVIFRFVEKASVRPL--NGLPAPGGLSRSWDLGGVSPPRPT 138
P P G+P PPGA + EK + P +G+ P GL P
Sbjct: 942 PIGPPGRPGPQGPPGAAGEKGVPG--EKGPIGPTGRDGVQGPVGL-------------PG 986
Query: 139 PALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPP----------QVGADGL 188
PA PG + + DP G G++ HGPP PP GADG
Sbjct: 987 PAGPPGVAGEDGDKGEVGDP----GQKGTKGNKG-EHGPPGPPGPIGPVGQPGAAGADGE 1041
Query: 189 YSSL-------------PNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRI 235
+ G GPP + L G P +G +G+T
Sbjct: 1042 PGARGPQGHFGAKGDEGTRGFNGPPGPIG-LQGLPGPSG--EKGET-------------- 1084
Query: 236 ARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDL--DTVPL 293
G + P P + P P G QG VG E ++
Sbjct: 1085 ---------GDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSP 1135
Query: 294 RCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYP-----PAPRPGPL-----PGPHP 343
E + ER E + QP GPPG P P PGP+ PGP
Sbjct: 1136 GIQGEPGVKGPRGERGEKGES--GQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPG 1193
Query: 344 SLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLP-GTSPSADGPDSF 402
G +D + G E E +PGS P P P G A P S
Sbjct: 1194 EGGPRGQDGAKGDRG----------EDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGS- 1242
Query: 403 SCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDP 455
E AKG PG +P T + P PA +P P
Sbjct: 1243 ----EGRQGGKGAKG-------------DPGAIGAPGKTGPVGPAGPAGKPGP 1278
Score = 41.2 bits (95), Expect = 0.005
Identities = 83/371 (22%), Positives = 112/371 (30%), Gaps = 52/371 (14%)
Query: 16 ISPPRCPRRWLPEGPV----PQSPPASMY-----------GSTGS--LLRRVAGPGPRGR 58
+ PP P P GP PQ PP + G +GS + GPRG
Sbjct: 1090 MGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGE 1149
Query: 59 --ELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQP----------PPGAQSSVVIFRFV 106
E G P P GPP P+ P P G P PPG
Sbjct: 1150 RGEKGESGQPGEP--GPPGPK---GPTGDDGPKGNPGPVGFPGDPGPPG----------- 1193
Query: 107 EKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSA 166
+ R +G A G + G P PT GP R A + +GG
Sbjct: 1194 -EGGPRGQDG--AKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKG 1250
Query: 167 LPGSRNLVHGPPAPPQVGADGLYSSL-PNGLGGPPERLATLFGGPADTGFLNQGDTWSSP 225
G + P VG G P+GL G P + G P TG P
Sbjct: 1251 AKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQ-GRPGATGQAGPPGPVGPP 1309
Query: 226 REVSSHAQRIARAKWEF--FYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKY 283
A+ + G + PP + ++ P P G ++G G +
Sbjct: 1310 GLPGLRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPI 1369
Query: 284 SETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHP 343
+P + + + ++ P GPPG P P P
Sbjct: 1370 GPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRS 1429
Query: 344 SLGSGNEDEDD 354
GS ED+
Sbjct: 1430 VDGSRLMQEDE 1440
Score = 40.8 bits (94), Expect = 0.007
Identities = 81/347 (23%), Positives = 102/347 (29%), Gaps = 62/347 (17%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTP-LRGPPSPRVAPSPWAP 85
PEGP P + G+ G V PG RG GR P + GPP + P+
Sbjct: 317 PEGPAGLIGPPGIQGNPGP----VGDPGERGPP-GRAGLPGSDGAPGPPGTSLM-LPFRF 370
Query: 86 SSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLS----------------RSWDL 129
S G P + + + + + L G P P G + S DL
Sbjct: 371 GSGGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDL 430
Query: 130 GGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLY 189
G P P GP R A G + G R P P + G G
Sbjct: 431 GPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRG-- 488
Query: 190 SSLPNGLGGPPERLAT-----------LFGGPADTGFLNQGDTWSSPREVSSHAQRIARA 238
+ GL GPP L G G L P +
Sbjct: 489 DTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPQG 548
Query: 239 KWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRE 298
GSL P P +Q P G+ QG+ G + L +P
Sbjct: 549 P----KGSLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGKPGLPGMP------ 598
Query: 299 TDIDEVLAEREEADSAIESQPSSEGPPGTA--YPPAPRPGPL--PGP 341
P EGPPGT P+ GPL PGP
Sbjct: 599 ------------GSDGPPGHPGKEGPPGTKGNQGPSGPQGPLGYPGP 633
Score = 40.8 bits (94), Expect = 0.007
Identities = 118/477 (24%), Positives = 152/477 (31%), Gaps = 111/477 (23%)
Query: 53 PGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVR 112
PGP G E G T P+ GPP P P P P+ P G P
Sbjct: 1075 PGPSG-EKGE-TGDVGPM-GPPGP---PGPRGPAGPNGADGPQG---------------- 1112
Query: 113 PLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRN 172
PGG +G + PP G + ++ E P RG G
Sbjct: 1113 ------PPGG------VGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGERGEKGESGQ-- 1158
Query: 173 LVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHA 232
G P PP G G P G GP G P GF GD P E
Sbjct: 1159 --PGEPGPP--GPKG-----PTGDDGPK-------GNPGPVGF--PGDP-GPPGEGGPRG 1199
Query: 233 QRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGR-AAKYSETDLDTV 291
Q A+ G P S E PP P G GS + GR K ++ D +
Sbjct: 1200 QDGAKGD-RGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKGAKGDPGAI 1258
Query: 292 PLRCYRETDIDEVLAEREEADSAIESQPSS------EGPPGTAYPPAP-RPGPLPGPHPS 344
+ + + + P S G G A PP P P LPG
Sbjct: 1259 GAP-GKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGD 1317
Query: 345 LGSGNEDEDDDEAG-----GEE-DVDDEVFEASEGARPGSRMPLKSP---VPFLPGTSPS 395
G+ E G GE+ + D +G+ PG + + P P PG P
Sbjct: 1318 AGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGS-PGQKGEMGIPGASGPIGPGGPPG 1376
Query: 396 ADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDP 455
GP AKG + PG + E Q P P P
Sbjct: 1377 LPGPAG----------PKGAKGAT-----------GPGGPKG-----EKGVQGPPGHPGP 1410
Query: 456 PAPA--PLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLG 510
P PL P++ T + DG ++ +E+EA + G P SP E+ G
Sbjct: 1411 PGEVIQPL-PIQMPKKTRRSVDG--SRLMQEDEA-----IPTGGAPGSPGGLEEIFG 1459
Score = 38.1 bits (87), Expect = 0.043
Identities = 98/411 (23%), Positives = 123/411 (29%), Gaps = 50/411 (12%)
Query: 29 GPVPQSPPASMYGSTGSLLRRVAGP----GPRGRE--LGRVTAPCTP----------LRG 72
GP + P G+ G+ + + GP GP G + G+ P P G
Sbjct: 554 GPQGEPGPPGQQGTPGT--QGLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPGHPGKEG 611
Query: 73 PPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVE-KASVRPLNGLPA-PGGLSRSWDLG 130
PP + P P P G P P V R ++ + +G P G + D G
Sbjct: 612 PPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRG 671
Query: 131 GVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYS 190
V P GP + T DP G L G + + P P G G
Sbjct: 672 EVGVPGSRGEDGPEGPK--GRTGPTGDP----GPPGLMGEKGKLGVPGLPGYPGRQGPKG 725
Query: 191 SL-----PNGLGGPPERLATLFGGP----ADTGFLNQ----GDTWSSPREVSSHAQRIAR 237
SL P G R + GP TG Q G T S + +S
Sbjct: 726 SLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHG 785
Query: 238 AKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYR 297
E G P P + PP PPG G G +T P
Sbjct: 786 PPGE--RGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGP 843
Query: 298 ETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLP-------GPHPSLGSGNE 350
+ E E P +G PGTA + P P GP G E
Sbjct: 844 QGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGE 903
Query: 351 DEDDDEAGGEEDVDDEVFEASEG--ARPGSRMPLKSPVPFLPGTSPSADGP 399
AGG +E G PG R S P P P GP
Sbjct: 904 RGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGP 954
>gi|111118968 collagen, type XI, alpha 2 isoform 3 preproprotein [Homo
sapiens]
Length = 1629
Score = 61.2 bits (147), Expect = 5e-09
Identities = 123/477 (25%), Positives = 152/477 (31%), Gaps = 113/477 (23%)
Query: 33 QSPPASMYGSTGSLLRRVAGP-GPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSS---P 88
+S P G TG +R GP G G+ + T+ GPP R P P P+ P
Sbjct: 726 KSGPRGERGPTGPRGQR--GPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGP 783
Query: 89 TGQP-PPGAQSSVVIFRFVEKASVRPLNGLPA-PGGLSRSWDLGGVSPPRPTPALGP--- 143
G P PPG +GLP PG G PP P +GP
Sbjct: 784 KGPPGPPGK------------------DGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGA 825
Query: 144 -GSNRKLRLEASTSDPLPARGGSALPGS--RNLVHGPPAPPQV-GADGLYSSLPNGLGG- 198
G + P P G LPG+ + G P PP G DG P GL G
Sbjct: 826 AGETGPMGERGHPGPPGPP-GEQGLPGTAGKEGTKGDPGPPGAPGKDG-----PAGLRGF 879
Query: 199 PPER-LATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPP 257
P ER L GGP G N+G + P S +R A G + PP
Sbjct: 880 PGERGLPGTAGGPGLKG--NEGPS-GPPGPAGSPGERGAAGSG----GPIGPPG------ 926
Query: 258 EQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIES 317
P PPG +G
Sbjct: 927 RPGPQGPPGAAGEKGV-------------------------------------------- 942
Query: 318 QPSSEGPPG-TAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAG--GEEDVDDEVFEASEGA 374
P +GP G T P LPGP G ED D E G G++ E
Sbjct: 943 -PGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPG 1001
Query: 375 RPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGP 434
PG P+ P P A GP F A + L+ L PGP
Sbjct: 1002 PPGPIGPVGQPGAAGADGEPGARGPQGH---FGAKGDEGTRGFNGPPGPIGLQGL--PGP 1056
Query: 435 TQSPFFTFEL----PPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEA 487
+ T ++ PP PP PR P P G + GP ++GE E+
Sbjct: 1057 SGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNL--GPPGEKGEPGES 1111
Score = 56.6 bits (135), Expect = 1e-07
Identities = 119/473 (25%), Positives = 150/473 (31%), Gaps = 123/473 (26%)
Query: 27 PEGPVPQSPPASMYGSTGS--LLRRVAGPGPRGRELGRVTAPCTPLRGPPSPRVAPSPWA 84
P G + PA + G G L GPG +G E + P P G P R A
Sbjct: 864 PPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNE--GPSGPPGPA-GSPGERGAAGSGG 920
Query: 85 PSSPTGQP----PPGAQSSVVIFRFVEKASVRPL--NGLPAPGGLSRSWDLGGVSPPRPT 138
P P G+P PPGA + EK + P +G+ P GL P
Sbjct: 921 PIGPPGRPGPQGPPGAAGEKGVPG--EKGPIGPTGRDGVQGPVGL-------------PG 965
Query: 139 PALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPP----------QVGADGL 188
PA PG + + DP G G++ HGPP PP GADG
Sbjct: 966 PAGPPGVAGEDGDKGEVGDP----GQKGTKGNKG-EHGPPGPPGPIGPVGQPGAAGADGE 1020
Query: 189 YSSL-------------PNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRI 235
+ G GPP + L G P +G +G+T
Sbjct: 1021 PGARGPQGHFGAKGDEGTRGFNGPPGPIG-LQGLPGPSG--EKGET-------------- 1063
Query: 236 ARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDL--DTVPL 293
G + P P + P P G QG VG E ++
Sbjct: 1064 ---------GDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSP 1114
Query: 294 RCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYP-----PAPRPGPL-----PGPHP 343
E + ER E + QP GPPG P P PGP+ PGP
Sbjct: 1115 GIQGEPGVKGPRGERGEKGES--GQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPG 1172
Query: 344 SLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLP-GTSPSADGPDSF 402
G +D + G E E +PGS P P P G A P S
Sbjct: 1173 EGGPRGQDGAKGDRG----------EDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGS- 1221
Query: 403 SCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDP 455
E AKG PG +P T + P PA +P P
Sbjct: 1222 ----EGRQGGKGAKG-------------DPGAIGAPGKTGPVGPAGPAGKPGP 1257
Score = 41.2 bits (95), Expect = 0.005
Identities = 83/371 (22%), Positives = 112/371 (30%), Gaps = 52/371 (14%)
Query: 16 ISPPRCPRRWLPEGPV----PQSPPASMY-----------GSTGS--LLRRVAGPGPRGR 58
+ PP P P GP PQ PP + G +GS + GPRG
Sbjct: 1069 MGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGE 1128
Query: 59 --ELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQP----------PPGAQSSVVIFRFV 106
E G P P GPP P+ P P G P PPG
Sbjct: 1129 RGEKGESGQPGEP--GPPGPK---GPTGDDGPKGNPGPVGFPGDPGPPG----------- 1172
Query: 107 EKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSA 166
+ R +G A G + G P PT GP R A + +GG
Sbjct: 1173 -EGGPRGQDG--AKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKG 1229
Query: 167 LPGSRNLVHGPPAPPQVGADGLYSSL-PNGLGGPPERLATLFGGPADTGFLNQGDTWSSP 225
G + P VG G P+GL G P + G P TG P
Sbjct: 1230 AKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQ-GRPGATGQAGPPGPVGPP 1288
Query: 226 REVSSHAQRIARAKWEF--FYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKY 283
A+ + G + PP + ++ P P G ++G G +
Sbjct: 1289 GLPGLRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPI 1348
Query: 284 SETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHP 343
+P + + + ++ P GPPG P P P
Sbjct: 1349 GPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRS 1408
Query: 344 SLGSGNEDEDD 354
GS ED+
Sbjct: 1409 VDGSRLMQEDE 1419
Score = 40.8 bits (94), Expect = 0.007
Identities = 81/347 (23%), Positives = 102/347 (29%), Gaps = 62/347 (17%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTP-LRGPPSPRVAPSPWAP 85
PEGP P + G+ G V PG RG GR P + GPP + P+
Sbjct: 296 PEGPAGLIGPPGIQGNPGP----VGDPGERGPP-GRAGLPGSDGAPGPPGTSLM-LPFRF 349
Query: 86 SSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLS----------------RSWDL 129
S G P + + + + + L G P P G + S DL
Sbjct: 350 GSGGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDL 409
Query: 130 GGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLY 189
G P P GP R A G + G R P P + G G
Sbjct: 410 GPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRG-- 467
Query: 190 SSLPNGLGGPPERLAT-----------LFGGPADTGFLNQGDTWSSPREVSSHAQRIARA 238
+ GL GPP L G G L P +
Sbjct: 468 DTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPQG 527
Query: 239 KWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRE 298
GSL P P +Q P G+ QG+ G + L +P
Sbjct: 528 P----KGSLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGKPGLPGMP------ 577
Query: 299 TDIDEVLAEREEADSAIESQPSSEGPPGTA--YPPAPRPGPL--PGP 341
P EGPPGT P+ GPL PGP
Sbjct: 578 ------------GSDGPPGHPGKEGPPGTKGNQGPSGPQGPLGYPGP 612
Score = 40.8 bits (94), Expect = 0.007
Identities = 118/477 (24%), Positives = 152/477 (31%), Gaps = 111/477 (23%)
Query: 53 PGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVR 112
PGP G E G T P+ GPP P P P P+ P G P
Sbjct: 1054 PGPSG-EKGE-TGDVGPM-GPPGP---PGPRGPAGPNGADGPQG---------------- 1091
Query: 113 PLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRN 172
PGG +G + PP G + ++ E P RG G
Sbjct: 1092 ------PPGG------VGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGERGEKGESGQ-- 1137
Query: 173 LVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHA 232
G P PP G G P G GP G P GF GD P E
Sbjct: 1138 --PGEPGPP--GPKG-----PTGDDGPK-------GNPGPVGF--PGDP-GPPGEGGPRG 1178
Query: 233 QRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGR-AAKYSETDLDTV 291
Q A+ G P S E PP P G GS + GR K ++ D +
Sbjct: 1179 QDGAKGD-RGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKGAKGDPGAI 1237
Query: 292 PLRCYRETDIDEVLAEREEADSAIESQPSS------EGPPGTAYPPAP-RPGPLPGPHPS 344
+ + + + P S G G A PP P P LPG
Sbjct: 1238 GAP-GKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGD 1296
Query: 345 LGSGNEDEDDDEAG-----GEE-DVDDEVFEASEGARPGSRMPLKSP---VPFLPGTSPS 395
G+ E G GE+ + D +G+ PG + + P P PG P
Sbjct: 1297 AGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGS-PGQKGEMGIPGASGPIGPGGPPG 1355
Query: 396 ADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDP 455
GP AKG + PG + E Q P P P
Sbjct: 1356 LPGPAG----------PKGAKGAT-----------GPGGPKG-----EKGVQGPPGHPGP 1389
Query: 456 PAPA--PLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLG 510
P PL P++ T + DG ++ +E+EA + G P SP E+ G
Sbjct: 1390 PGEVIQPL-PIQMPKKTRRSVDG--SRLMQEDEA-----IPTGGAPGSPGGLEEIFG 1438
Score = 38.1 bits (87), Expect = 0.043
Identities = 98/411 (23%), Positives = 123/411 (29%), Gaps = 50/411 (12%)
Query: 29 GPVPQSPPASMYGSTGSLLRRVAGP----GPRGRE--LGRVTAPCTP----------LRG 72
GP + P G+ G+ + + GP GP G + G+ P P G
Sbjct: 533 GPQGEPGPPGQQGTPGT--QGLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPGHPGKEG 590
Query: 73 PPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVE-KASVRPLNGLPA-PGGLSRSWDLG 130
PP + P P P G P P V R ++ + +G P G + D G
Sbjct: 591 PPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRG 650
Query: 131 GVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYS 190
V P GP + T DP G L G + + P P G G
Sbjct: 651 EVGVPGSRGEDGPEGPK--GRTGPTGDP----GPPGLMGEKGKLGVPGLPGYPGRQGPKG 704
Query: 191 SL-----PNGLGGPPERLATLFGGP----ADTGFLNQ----GDTWSSPREVSSHAQRIAR 237
SL P G R + GP TG Q G T S + +S
Sbjct: 705 SLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHG 764
Query: 238 AKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYR 297
E G P P + PP PPG G G +T P
Sbjct: 765 PPGE--RGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGP 822
Query: 298 ETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLP-------GPHPSLGSGNE 350
+ E E P +G PGTA + P P GP G E
Sbjct: 823 QGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGE 882
Query: 351 DEDDDEAGGEEDVDDEVFEASEG--ARPGSRMPLKSPVPFLPGTSPSADGP 399
AGG +E G PG R S P P P GP
Sbjct: 883 RGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGP 933
>gi|111118970 collagen, type XI, alpha 2 isoform 1 preproprotein [Homo
sapiens]
Length = 1736
Score = 61.2 bits (147), Expect = 5e-09
Identities = 123/477 (25%), Positives = 152/477 (31%), Gaps = 113/477 (23%)
Query: 33 QSPPASMYGSTGSLLRRVAGP-GPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSS---P 88
+S P G TG +R GP G G+ + T+ GPP R P P P+ P
Sbjct: 833 KSGPRGERGPTGPRGQR--GPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGP 890
Query: 89 TGQP-PPGAQSSVVIFRFVEKASVRPLNGLPA-PGGLSRSWDLGGVSPPRPTPALGP--- 143
G P PPG +GLP PG G PP P +GP
Sbjct: 891 KGPPGPPGK------------------DGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGA 932
Query: 144 -GSNRKLRLEASTSDPLPARGGSALPGS--RNLVHGPPAPPQV-GADGLYSSLPNGLGG- 198
G + P P G LPG+ + G P PP G DG P GL G
Sbjct: 933 AGETGPMGERGHPGPPGPP-GEQGLPGTAGKEGTKGDPGPPGAPGKDG-----PAGLRGF 986
Query: 199 PPER-LATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPP 257
P ER L GGP G N+G + P S +R A G + PP
Sbjct: 987 PGERGLPGTAGGPGLKG--NEGPS-GPPGPAGSPGERGAAGSG----GPIGPPG------ 1033
Query: 258 EQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIES 317
P PPG +G
Sbjct: 1034 RPGPQGPPGAAGEKGV-------------------------------------------- 1049
Query: 318 QPSSEGPPG-TAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAG--GEEDVDDEVFEASEGA 374
P +GP G T P LPGP G ED D E G G++ E
Sbjct: 1050 -PGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPG 1108
Query: 375 RPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGP 434
PG P+ P P A GP F A + L+ L PGP
Sbjct: 1109 PPGPIGPVGQPGAAGADGEPGARGPQGH---FGAKGDEGTRGFNGPPGPIGLQGL--PGP 1163
Query: 435 TQSPFFTFEL----PPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEA 487
+ T ++ PP PP PR P P G + GP ++GE E+
Sbjct: 1164 SGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNL--GPPGEKGEPGES 1218
Score = 56.6 bits (135), Expect = 1e-07
Identities = 119/473 (25%), Positives = 150/473 (31%), Gaps = 123/473 (26%)
Query: 27 PEGPVPQSPPASMYGSTGS--LLRRVAGPGPRGRELGRVTAPCTPLRGPPSPRVAPSPWA 84
P G + PA + G G L GPG +G E + P P G P R A
Sbjct: 971 PPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNE--GPSGPPGPA-GSPGERGAAGSGG 1027
Query: 85 PSSPTGQP----PPGAQSSVVIFRFVEKASVRPL--NGLPAPGGLSRSWDLGGVSPPRPT 138
P P G+P PPGA + EK + P +G+ P GL P
Sbjct: 1028 PIGPPGRPGPQGPPGAAGEKGVPG--EKGPIGPTGRDGVQGPVGL-------------PG 1072
Query: 139 PALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPP----------QVGADGL 188
PA PG + + DP G G++ HGPP PP GADG
Sbjct: 1073 PAGPPGVAGEDGDKGEVGDP----GQKGTKGNKG-EHGPPGPPGPIGPVGQPGAAGADGE 1127
Query: 189 YSSL-------------PNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRI 235
+ G GPP + L G P +G +G+T
Sbjct: 1128 PGARGPQGHFGAKGDEGTRGFNGPPGPIG-LQGLPGPSG--EKGET-------------- 1170
Query: 236 ARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDL--DTVPL 293
G + P P + P P G QG VG E ++
Sbjct: 1171 ---------GDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSP 1221
Query: 294 RCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYP-----PAPRPGPL-----PGPHP 343
E + ER E + QP GPPG P P PGP+ PGP
Sbjct: 1222 GIQGEPGVKGPRGERGEKGES--GQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPG 1279
Query: 344 SLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLP-GTSPSADGPDSF 402
G +D + G E E +PGS P P P G A P S
Sbjct: 1280 EGGPRGQDGAKGDRG----------EDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGS- 1328
Query: 403 SCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDP 455
E AKG PG +P T + P PA +P P
Sbjct: 1329 ----EGRQGGKGAKG-------------DPGAIGAPGKTGPVGPAGPAGKPGP 1364
Score = 41.2 bits (95), Expect = 0.005
Identities = 83/371 (22%), Positives = 112/371 (30%), Gaps = 52/371 (14%)
Query: 16 ISPPRCPRRWLPEGPV----PQSPPASMY-----------GSTGS--LLRRVAGPGPRGR 58
+ PP P P GP PQ PP + G +GS + GPRG
Sbjct: 1176 MGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGE 1235
Query: 59 --ELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQP----------PPGAQSSVVIFRFV 106
E G P P GPP P+ P P G P PPG
Sbjct: 1236 RGEKGESGQPGEP--GPPGPK---GPTGDDGPKGNPGPVGFPGDPGPPG----------- 1279
Query: 107 EKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSA 166
+ R +G A G + G P PT GP R A + +GG
Sbjct: 1280 -EGGPRGQDG--AKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKG 1336
Query: 167 LPGSRNLVHGPPAPPQVGADGLYSSL-PNGLGGPPERLATLFGGPADTGFLNQGDTWSSP 225
G + P VG G P+GL G P + G P TG P
Sbjct: 1337 AKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQ-GRPGATGQAGPPGPVGPP 1395
Query: 226 REVSSHAQRIARAKWEF--FYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKY 283
A+ + G + PP + ++ P P G ++G G +
Sbjct: 1396 GLPGLRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPI 1455
Query: 284 SETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHP 343
+P + + + ++ P GPPG P P P
Sbjct: 1456 GPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRS 1515
Query: 344 SLGSGNEDEDD 354
GS ED+
Sbjct: 1516 VDGSRLMQEDE 1526
Score = 40.8 bits (94), Expect = 0.007
Identities = 81/347 (23%), Positives = 102/347 (29%), Gaps = 62/347 (17%)
Query: 27 PEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTP-LRGPPSPRVAPSPWAP 85
PEGP P + G+ G V PG RG GR P + GPP + P+
Sbjct: 403 PEGPAGLIGPPGIQGNPGP----VGDPGERGPP-GRAGLPGSDGAPGPPGTSLM-LPFRF 456
Query: 86 SSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLS----------------RSWDL 129
S G P + + + + + L G P P G + S DL
Sbjct: 457 GSGGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDL 516
Query: 130 GGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLY 189
G P P GP R A G + G R P P + G G
Sbjct: 517 GPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRG-- 574
Query: 190 SSLPNGLGGPPERLAT-----------LFGGPADTGFLNQGDTWSSPREVSSHAQRIARA 238
+ GL GPP L G G L P +
Sbjct: 575 DTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPQG 634
Query: 239 KWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRE 298
GSL P P +Q P G+ QG+ G + L +P
Sbjct: 635 P----KGSLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGKPGLPGMP------ 684
Query: 299 TDIDEVLAEREEADSAIESQPSSEGPPGTA--YPPAPRPGPL--PGP 341
P EGPPGT P+ GPL PGP
Sbjct: 685 ------------GSDGPPGHPGKEGPPGTKGNQGPSGPQGPLGYPGP 719
Score = 40.8 bits (94), Expect = 0.007
Identities = 118/477 (24%), Positives = 152/477 (31%), Gaps = 111/477 (23%)
Query: 53 PGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVR 112
PGP G E G T P+ GPP P P P P+ P G P
Sbjct: 1161 PGPSG-EKGE-TGDVGPM-GPPGP---PGPRGPAGPNGADGPQG---------------- 1198
Query: 113 PLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRN 172
PGG +G + PP G + ++ E P RG G
Sbjct: 1199 ------PPGG------VGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGERGEKGESGQ-- 1244
Query: 173 LVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHA 232
G P PP G G P G GP G P GF GD P E
Sbjct: 1245 --PGEPGPP--GPKG-----PTGDDGPK-------GNPGPVGF--PGDP-GPPGEGGPRG 1285
Query: 233 QRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGR-AAKYSETDLDTV 291
Q A+ G P S E PP P G GS + GR K ++ D +
Sbjct: 1286 QDGAKGD-RGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKGAKGDPGAI 1344
Query: 292 PLRCYRETDIDEVLAEREEADSAIESQPSS------EGPPGTAYPPAP-RPGPLPGPHPS 344
+ + + + P S G G A PP P P LPG
Sbjct: 1345 GAP-GKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGD 1403
Query: 345 LGSGNEDEDDDEAG-----GEE-DVDDEVFEASEGARPGSRMPLKSP---VPFLPGTSPS 395
G+ E G GE+ + D +G+ PG + + P P PG P
Sbjct: 1404 AGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGS-PGQKGEMGIPGASGPIGPGGPPG 1462
Query: 396 ADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDP 455
GP AKG + PG + E Q P P P
Sbjct: 1463 LPGPAG----------PKGAKGAT-----------GPGGPKG-----EKGVQGPPGHPGP 1496
Query: 456 PAPA--PLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLG 510
P PL P++ T + DG ++ +E+EA + G P SP E+ G
Sbjct: 1497 PGEVIQPL-PIQMPKKTRRSVDG--SRLMQEDEA-----IPTGGAPGSPGGLEEIFG 1545
Score = 38.1 bits (87), Expect = 0.043
Identities = 98/411 (23%), Positives = 123/411 (29%), Gaps = 50/411 (12%)
Query: 29 GPVPQSPPASMYGSTGSLLRRVAGP----GPRGRE--LGRVTAPCTP----------LRG 72
GP + P G+ G+ + + GP GP G + G+ P P G
Sbjct: 640 GPQGEPGPPGQQGTPGT--QGLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPGHPGKEG 697
Query: 73 PPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVE-KASVRPLNGLPA-PGGLSRSWDLG 130
PP + P P P G P P V R ++ + +G P G + D G
Sbjct: 698 PPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRG 757
Query: 131 GVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYS 190
V P GP + T DP G L G + + P P G G
Sbjct: 758 EVGVPGSRGEDGPEGPK--GRTGPTGDP----GPPGLMGEKGKLGVPGLPGYPGRQGPKG 811
Query: 191 SL-----PNGLGGPPERLATLFGGP----ADTGFLNQ----GDTWSSPREVSSHAQRIAR 237
SL P G R + GP TG Q G T S + +S
Sbjct: 812 SLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHG 871
Query: 238 AKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYR 297
E G P P + PP PPG G G +T P
Sbjct: 872 PPGE--RGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGP 929
Query: 298 ETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLP-------GPHPSLGSGNE 350
+ E E P +G PGTA + P P GP G E
Sbjct: 930 QGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGE 989
Query: 351 DEDDDEAGGEEDVDDEVFEASEG--ARPGSRMPLKSPVPFLPGTSPSADGP 399
AGG +E G PG R S P P P GP
Sbjct: 990 RGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGP 1040
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,464,277
Number of Sequences: 37866
Number of extensions: 3528553
Number of successful extensions: 41851
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 251
Number of HSP's successfully gapped in prelim test: 1619
Number of HSP's that attempted gapping in prelim test: 23138
Number of HSP's gapped (non-prelim): 14299
length of query: 1024
length of database: 18,247,518
effective HSP length: 112
effective length of query: 912
effective length of database: 14,006,526
effective search space: 12773951712
effective search space used: 12773951712
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.