Guide to the Human Genome
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Search of human proteins with 13259541

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13259541 uncoupling protein 2 [Homo sapiens]
         (309 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13259541 uncoupling protein 2 [Homo sapiens]                       611   e-175
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]          445   e-125
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]         387   e-108
gi|11225256 uncoupling protein 1 [Homo sapiens]                       354   5e-98
gi|58197562 solute carrier family 25, member 30 [Homo sapiens]        201   9e-52
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho...   199   2e-51
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H...   199   2e-51
gi|108860679 solute carrier family 25, member 27 [Homo sapiens]       181   7e-46
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic...   167   8e-42
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo...   158   7e-39
gi|46409330 solute carrier family 25, member 34 [Homo sapiens]        132   4e-31
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]        105   5e-23
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit...   104   9e-23
gi|156071462 solute carrier family 25, member A6 [Homo sapiens]        95   9e-20
gi|41462412 solute carrier family 25, member 35 [Homo sapiens]         95   9e-20
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s...    94   1e-19
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo...    94   1e-19
gi|156071459 solute carrier family 25, member 5 [Homo sapiens]         94   2e-19
gi|186928856 solute carrier family 25, member 19 [Homo sapiens]        92   6e-19
gi|186928860 solute carrier family 25, member 19 [Homo sapiens]        92   6e-19
gi|186928858 solute carrier family 25, member 19 [Homo sapiens]        92   6e-19
gi|21361103 solute carrier family 25, member 12 [Homo sapiens]         91   2e-18
gi|157388925 solute carrier family 25, member 38 [Homo sapiens]        90   2e-18
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade...    90   2e-18
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade...    89   6e-18
gi|239755176 PREDICTED: similar to solute carrier family 25, mem...    89   6e-18
gi|239755174 PREDICTED: similar to solute carrier family 25, mem...    89   6e-18
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ...    89   6e-18
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ...    89   6e-18
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ...    89   6e-18

>gi|13259541 uncoupling protein 2 [Homo sapiens]
          Length = 309

 Score =  611 bits (1576), Expect = e-175
 Identities = 309/309 (100%), Positives = 309/309 (100%)

Query: 1   MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60
           MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR
Sbjct: 1   MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60

Query: 61  GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL 120
           GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL
Sbjct: 61  GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL 120

Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180
           LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS
Sbjct: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180

Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT 240
           PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT
Sbjct: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT 240

Query: 241 RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA 300
           RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA
Sbjct: 241 RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA 300

Query: 301 ACTSREAPF 309
           ACTSREAPF
Sbjct: 301 ACTSREAPF 309


>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
          Length = 312

 Score =  445 bits (1144), Expect = e-125
 Identities = 226/313 (72%), Positives = 257/313 (82%), Gaps = 5/313 (1%)

Query: 1   MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60
           MVG K +DVPPT  VKFLGAGTAAC ADL+TFPLDTAKVRLQIQGE+Q  V+     QYR
Sbjct: 1   MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQA-VQTARLVQYR 59

Query: 61  GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYT-KGSEHASIGSR 119
           GV+GTILTMVRTEGP S YNGLVAGLQRQMSFAS+RIGLYDSVKQ YT KG++++S+ +R
Sbjct: 60  GVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTR 119

Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLW 176
           +LAG TTGA+AV  AQPTDVVKVRFQA    G     R+Y  T++AY+TIAREEG RGLW
Sbjct: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179

Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVD 236
           KGT PN+ RNAIVNCAE+VTYD++K+ LL  +L+TD+ PCHF SAFGAGFC TV+ASPVD
Sbjct: 180 KGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVD 239

Query: 237 VVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
           VVKTRYMNS  GQY S   C + M+ +EGP AFYKGF PSFLRLGSWNVVMFVTYEQLKR
Sbjct: 240 VVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR 299

Query: 297 ALMAACTSREAPF 309
           ALM     RE+PF
Sbjct: 300 ALMKVQMLRESPF 312


>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
          Length = 275

 Score =  387 bits (993), Expect = e-108
 Identities = 196/276 (71%), Positives = 226/276 (81%), Gaps = 5/276 (1%)

Query: 1   MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60
           MVG K +DVPPT  VKFLGAGTAAC ADL+TFPLDTAKVRLQIQGE+Q  V+     QYR
Sbjct: 1   MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQA-VQTARLVQYR 59

Query: 61  GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYT-KGSEHASIGSR 119
           GV+GTILTMVRTEGP S YNGLVAGLQRQMSFAS+RIGLYDSVKQ YT KG++++S+ +R
Sbjct: 60  GVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTR 119

Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLW 176
           +LAG TTGA+AV  AQPTDVVKVRFQA    G     R+Y  T++AY+TIAREEG RGLW
Sbjct: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179

Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVD 236
           KGT PN+ RNAIVNCAE+VTYD++K+ LL  +L+TD+ PCHF SAFGAGFC TV+ASPVD
Sbjct: 180 KGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVD 239

Query: 237 VVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKG 272
           VVKTRYMNS  GQY S   C + M+ +EGP AFYKG
Sbjct: 240 VVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 50/193 (25%), Positives = 72/193 (37%), Gaps = 12/193 (6%)

Query: 119 RLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR-----RYQSTVNAYKTIAREEGFR 173
           + L   T    A  V  P D  KVR Q Q      +     +Y+  +    T+ R EG  
Sbjct: 16  KFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPC 75

Query: 174 GLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIAS 233
             + G    + R        +  YD +K            L     +    G      A 
Sbjct: 76  SPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQ 135

Query: 234 PVDVVKTRYMNSA-LG------QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVV 286
           P DVVK R+  S  LG      +YS       T+ ++EG R  +KG +P+ +R    N  
Sbjct: 136 PTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195

Query: 287 MFVTYEQLKRALM 299
             VTY+ LK  L+
Sbjct: 196 EVVTYDILKEKLL 208


>gi|11225256 uncoupling protein 1 [Homo sapiens]
          Length = 307

 Score =  354 bits (909), Expect = 5e-98
 Identities = 178/300 (59%), Positives = 226/300 (75%), Gaps = 6/300 (2%)

Query: 1   MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60
           M G  A+DV PT  V+   AG AAC+AD+ITFPLDTAKVRLQ+QGE       ++  +Y+
Sbjct: 1   MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECP----TSSVIRYK 56

Query: 61  GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHA-SIGSR 119
           GV+GTI  +V+TEG   LY+GL AGLQRQ+S AS+RIGLYD+V++F T G E A S+GS+
Sbjct: 57  GVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSK 116

Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR-RYQSTVNAYKTIAREEGFRGLWKG 178
           +LAG TTG +AV + QPT+VVKVR QAQ+   G + RY  T NAY+ IA  EG  GLWKG
Sbjct: 117 ILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKG 176

Query: 179 TSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVV 238
           T+PN+ R+ I+NC ELVTYDL+K+A +K N++ DD+PCH  SA  AGFC T ++SPVDVV
Sbjct: 177 TTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVV 236

Query: 239 KTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
           KTR++NS  GQY S  +CA+ +   EGP AF+KG +PSFLRLGSWNV+MFV +EQLKR L
Sbjct: 237 KTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKREL 296



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 54/206 (26%), Positives = 81/206 (39%), Gaps = 10/206 (4%)

Query: 8   DVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTIL 67
           +  P+   K L   T   +A  I  P +  KVRLQ Q    G        +Y G      
Sbjct: 108 ETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHG-----IKPRYTGTYNAYR 162

Query: 68  TMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-IGSRLLAGSTT 126
            +  TEG   L+ G    L R +      +  YD +K+ + K +  A  +   L++    
Sbjct: 163 IIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIA 222

Query: 127 GALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARN 186
           G  A A++ P DVVK RF          +Y+S  N    +   EG    +KG  P+  R 
Sbjct: 223 GFCATAMSSPVDVVKTRFINSPPG----QYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRL 278

Query: 187 AIVNCAELVTYDLIKDALLKANLMTD 212
              N    V ++ +K  L K+    D
Sbjct: 279 GSWNVIMFVCFEQLKRELSKSRQTMD 304



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 44/199 (22%), Positives = 74/199 (37%), Gaps = 7/199 (3%)

Query: 108 TKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR--RYQSTVNAYKT 165
           T    H ++G +L +      LA  +  P D  KVR Q Q         RY+  +     
Sbjct: 5   TASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITA 64

Query: 166 IAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAG 225
           + + EG   L+ G    + R        +  YD +++ L         L     +    G
Sbjct: 65  VVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTG 124

Query: 226 FCTTVIASPVDVVKTR-----YMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRL 280
                I  P +VVK R     +++    +Y+   +    +   EG    +KG  P+ +R 
Sbjct: 125 GVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRS 184

Query: 281 GSWNVVMFVTYEQLKRALM 299
              N    VTY+ +K A +
Sbjct: 185 VIINCTELVTYDLMKEAFV 203



 Score = 28.9 bits (63), Expect = 6.0
 Identities = 24/107 (22%), Positives = 42/107 (39%), Gaps = 14/107 (13%)

Query: 6   ATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGT 65
           A DVP       + A  A   A  ++ P+D  K R             +   QY+ V   
Sbjct: 209 ADDVP----CHLVSALIAGFCATAMSSPVDVVKTRFI----------NSPPGQYKSVPNC 254

Query: 66  ILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSE 112
            + +   EGP + + GLV    R  S+  +    ++ +K+  +K  +
Sbjct: 255 AMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQ 301


>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
          Length = 291

 Score =  201 bits (510), Expect = 9e-52
 Identities = 109/286 (38%), Positives = 166/286 (58%), Gaps = 12/286 (4%)

Query: 17  FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76
           F+  G A+  A+  TFP+D  K RLQIQG++          +YRG++  ++ + R EG +
Sbjct: 9   FVYGGLASITAECGTFPIDLTKTRLQIQGQTNDA--KFKEIRYRGMLHALVRIGREEGLK 66

Query: 77  SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQP 136
           +LY+G+   + RQ S+ +++IG Y S+K+ + +  E  ++   ++ G  +G ++  +A P
Sbjct: 67  ALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTIANP 126

Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
           TDV+K+R QAQ+    G    + +N Y    ++EG RGLWKG S    R AIV   EL  
Sbjct: 127 TDVLKIRMQAQSNTIQGGMIGNFMNIY----QQEGTRGLWKGVSLTAQRAAIVVGVELPV 182

Query: 197 YDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL------GQY 250
           YD+ K  L+ + LM D +  HF S+F  G    + ++PVDVV+TR MN  +        Y
Sbjct: 183 YDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCSGY 242

Query: 251 SSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
           +    C L   + EG  A YKGF P++LRLG WN++ FVTYEQLK+
Sbjct: 243 TGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKK 288


>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
           sapiens]
          Length = 325

 Score =  199 bits (507), Expect = 2e-51
 Identities = 107/285 (37%), Positives = 164/285 (57%), Gaps = 11/285 (3%)

Query: 17  FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76
           F+  G A+ +A+  TFP+D  K RLQ+QG+S          +YRG+   +  + + EG  
Sbjct: 44  FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDA--RFKEIKYRGMFHALFRICKEEGVL 101

Query: 77  SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQP 136
           +LY+G+   L RQ S+ +++IG+Y S+K+ + +  E  ++   ++ G  +G ++  +A P
Sbjct: 102 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 161

Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
           TDV+K+R QAQ     G    S + ++  I ++EG RGLW+G  P   R AIV   EL  
Sbjct: 162 TDVLKIRMQAQGSLFQG----SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPV 217

Query: 197 YDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-----LGQYS 251
           YD+ K  L+ + +M D +  HF S+F  G    + ++PVDVV+TR MN       +  Y 
Sbjct: 218 YDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYK 277

Query: 252 SAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
                 L M + EG  A YKGF P++LRLG WN++ F+TYEQLKR
Sbjct: 278 GTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 322



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 12/192 (6%)

Query: 12  TATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVR 71
           T  +  +    +  I+  I  P D  K+R+Q QG          S     ++G+ + + +
Sbjct: 140 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQG----------SLFQGSMIGSFIDIYQ 189

Query: 72  TEGPRSLYNGLVAGLQRQMSFASVRIGLYD-SVKQFYTKGSEHASIGSRLLAGSTTGALA 130
            EG R L+ G+V   QR      V + +YD + K     G    +I +  ++  T G   
Sbjct: 190 QEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAG 249

Query: 131 VAVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189
              + P DVV+ R   Q A  G    Y+ TV+    + + EGF  L+KG  PN  R    
Sbjct: 250 ALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPW 309

Query: 190 NCAELVTYDLIK 201
           N    +TY+ +K
Sbjct: 310 NIIFFITYEQLK 321


>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
           sapiens]
          Length = 322

 Score =  199 bits (507), Expect = 2e-51
 Identities = 107/285 (37%), Positives = 164/285 (57%), Gaps = 11/285 (3%)

Query: 17  FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76
           F+  G A+ +A+  TFP+D  K RLQ+QG+S          +YRG+   +  + + EG  
Sbjct: 41  FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDA--RFKEIKYRGMFHALFRICKEEGVL 98

Query: 77  SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQP 136
           +LY+G+   L RQ S+ +++IG+Y S+K+ + +  E  ++   ++ G  +G ++  +A P
Sbjct: 99  ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 158

Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
           TDV+K+R QAQ     G    S + ++  I ++EG RGLW+G  P   R AIV   EL  
Sbjct: 159 TDVLKIRMQAQGSLFQG----SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPV 214

Query: 197 YDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-----LGQYS 251
           YD+ K  L+ + +M D +  HF S+F  G    + ++PVDVV+TR MN       +  Y 
Sbjct: 215 YDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYK 274

Query: 252 SAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
                 L M + EG  A YKGF P++LRLG WN++ F+TYEQLKR
Sbjct: 275 GTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 12/192 (6%)

Query: 12  TATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVR 71
           T  +  +    +  I+  I  P D  K+R+Q QG          S     ++G+ + + +
Sbjct: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQG----------SLFQGSMIGSFIDIYQ 186

Query: 72  TEGPRSLYNGLVAGLQRQMSFASVRIGLYD-SVKQFYTKGSEHASIGSRLLAGSTTGALA 130
            EG R L+ G+V   QR      V + +YD + K     G    +I +  ++  T G   
Sbjct: 187 QEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAG 246

Query: 131 VAVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189
              + P DVV+ R   Q A  G    Y+ TV+    + + EGF  L+KG  PN  R    
Sbjct: 247 ALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPW 306

Query: 190 NCAELVTYDLIK 201
           N    +TY+ +K
Sbjct: 307 NIIFFITYEQLK 318


>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
          Length = 323

 Score =  181 bits (459), Expect = 7e-46
 Identities = 101/294 (34%), Positives = 166/294 (56%), Gaps = 14/294 (4%)

Query: 16  KFLGAGTAACIADLITFPLDTAKVRLQIQGES---QGPVRATASAQYRGVMGTILTMVRT 72
           KFL +G AA +A+L TFPLD  K RLQ+QGE+   +    A  SA YRG++ T L ++  
Sbjct: 22  KFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEE 81

Query: 73  EGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQ--FYTKGSEHASIGSRLLAGSTTGALA 130
           EG   L+ G+   + R + ++  R+  Y+ +++  F     EH  +   ++ G   G + 
Sbjct: 82  EGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIG 141

Query: 131 VAVAQPTDVVKVRFQAQARA---GGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNA 187
             +A PTD+VKV+ Q + +    G   R++   +A+  I  E G RGLW G  PN+ R A
Sbjct: 142 QFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAA 201

Query: 188 IVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL 247
           +VN  +L TYD +K  L+    + D++  H  S+  +G   +++ +P DV+K+R MN   
Sbjct: 202 LVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPR 261

Query: 248 GQ------YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295
            +      Y S+  C +  +Q EG  + YKGF+PS+LR+  W++V ++TYE+++
Sbjct: 262 DKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIR 315



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 51/191 (26%), Positives = 87/191 (45%), Gaps = 12/191 (6%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQ---GPVRATASAQYRGVMGTILTMVRTEG 74
           +G   A  I   +  P D  KV++Q++G+ +    P+R      +RGV      ++   G
Sbjct: 132 IGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLR------FRGVHHAFAKILAEGG 185

Query: 75  PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSE-HASIGSRLLAGSTTGALAVAV 133
            R L+ G V  +QR        +  YD+VK +    +    +I +  L+   +G +A  +
Sbjct: 186 IRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASIL 245

Query: 134 AQPTDVVKVRFQAQAR--AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNC 191
             P DV+K R   Q R   G G  Y+S+ +      + EGF  L+KG  P+  R    + 
Sbjct: 246 GTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSM 305

Query: 192 AELVTYDLIKD 202
              +TY+ I++
Sbjct: 306 VFWLTYEKIRE 316


>gi|20149598 solute carrier family 25 (mitochondrial carrier;
           dicarboxylate transporter), member 10 [Homo sapiens]
          Length = 287

 Score =  167 bits (424), Expect = 8e-42
 Identities = 106/279 (37%), Positives = 153/279 (54%), Gaps = 16/279 (5%)

Query: 21  GTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYN 80
           G A+C A   T PLD  KV LQ Q E +  +R T         G  L +VRT+G  +LY+
Sbjct: 14  GLASCGAACCTHPLDLLKVHLQTQQEVK--LRMT---------GMALRVVRTDGILALYS 62

Query: 81  GLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHA-SIGSRLLAGSTTGALAVAVAQPTDV 139
           GL A L RQM+++  R  +Y++V+    KGS+       ++L GS +G     V  P D+
Sbjct: 63  GLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADL 122

Query: 140 VKVRFQAQARAGGGRR--YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197
           V VR Q   +   G+R  Y   ++    +AREEG R L+ G +   +R A+V   +L  Y
Sbjct: 123 VNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182

Query: 198 DLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCA 257
           D  K  +L    ++D++  HF ++F AG C T +  P+DV+KTR MNS  G+Y    HCA
Sbjct: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSK-GEYQGVFHCA 241

Query: 258 LTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
           +    K GP AFYKG +P+ +RL    V+ FV  EQL++
Sbjct: 242 VE-TAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279


>gi|21361114 solute carrier family 25 (mitochondrial carrier;
           oxoglutarate carrier), member 11 [Homo sapiens]
          Length = 314

 Score =  158 bits (399), Expect = 7e-39
 Identities = 97/292 (33%), Positives = 151/292 (51%), Gaps = 15/292 (5%)

Query: 14  TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73
           +VKFL  G A   A +   PLD  K R+Q+ GE         + +Y+     + ++++ E
Sbjct: 22  SVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEG------AKTREYKTSFHALTSILKAE 75

Query: 74  GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLA--GSTTGALAV 131
           G R +Y GL AGL RQ ++ + R+G+Y  + +  T G++    G  L A  G T GA   
Sbjct: 76  GLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLT-GADGTPPGFLLKAVIGMTAGATGA 134

Query: 132 AVAQPTDVVKVRFQAQARAGGGRR--YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189
            V  P +V  +R  A  R    +R  Y++  NA   I REEG   LW+G  P +AR  +V
Sbjct: 135 FVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVV 194

Query: 190 NCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL-- 247
           N A+L +Y   K  LL +   +D++ CHF ++  +G  TT  + PVD+ KTR  N  +  
Sbjct: 195 NAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMID 254

Query: 248 --GQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
              +Y +       +++ EG  + +KGF P + RLG   V+ F+  EQ+ +A
Sbjct: 255 GKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKA 306



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 45/189 (23%), Positives = 78/189 (41%), Gaps = 10/189 (5%)

Query: 119 RLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKG 178
           + L G   G  A    QP D+VK R Q        R Y+++ +A  +I + EG RG++ G
Sbjct: 24  KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83

Query: 179 TSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVV 238
            S  + R A      L  Y ++ + L  A+               AG     + +P +V 
Sbjct: 84  LSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVA 143

Query: 239 KTRYMNSALGQ--------YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVT 290
             R   +A G+        Y +  +  + + ++EG    ++G +P+  R    N     +
Sbjct: 144 LIRM--TADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLAS 201

Query: 291 YEQLKRALM 299
           Y Q K+ L+
Sbjct: 202 YSQSKQFLL 210


>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
          Length = 304

 Score =  132 bits (332), Expect = 4e-31
 Identities = 96/302 (31%), Positives = 147/302 (48%), Gaps = 25/302 (8%)

Query: 9   VPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILT 68
           VPP   +  LGA +A C+A + T PL+  K RLQ+QGE Q   R T    Y G + ++  
Sbjct: 4   VPPAVDL-VLGA-SACCLACVFTNPLEVVKTRLQLQGELQA--RGTYPRPYHGFIASVAA 59

Query: 69  MVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGA 128
           + R +G   L  GL AGL  Q     VR   Y    Q           G  ++AG+  GA
Sbjct: 60  VARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ----AGLTQQPGGTVVAGAVAGA 115

Query: 129 LAVAVAQPTDVVKVRFQAQARA----GGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVA 184
           L   V  P  ++K + QAQ  A    G    +Q+ + A +TI R++G  GLW+G    V 
Sbjct: 116 LGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVP 175

Query: 185 RNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTT----VIASPVDVVKT 240
           R  + + A+L T+   K  + K   + +D    +  A   G  ++    V+ +P DVV T
Sbjct: 176 RVMVGSAAQLATFASAKAWVQKQQWLPED---SWLVALAGGMISSIAVVVVMTPFDVVST 232

Query: 241 RYMNSAL-----GQ-YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294
           R  N  +     GQ Y     C + + ++EGP A YKG  P++LRLG   ++  + +++L
Sbjct: 233 RLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDEL 292

Query: 295 KR 296
           ++
Sbjct: 293 RK 294


>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
          Length = 308

 Score =  105 bits (262), Expect = 5e-23
 Identities = 81/298 (27%), Positives = 128/298 (42%), Gaps = 43/298 (14%)

Query: 30  ITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGL-----VA 84
           + +PLDT KVR+Q +             +Y G+   +      E     Y GL       
Sbjct: 16  VGYPLDTVKVRIQTE------------PKYTGIWHCVRDTYHRERVWGFYRGLSLPVCTV 63

Query: 85  GLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRF 144
            L   +SF + R  L    +  Y       +     L+G  +G + V +  PT+V KVR 
Sbjct: 64  SLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRL 123

Query: 145 QAQARAGGGRR------------------------YQSTVNAYKTIAREEGFRGLWKGTS 180
           Q Q +A   +R                        Y+  ++   T+AREEG  GL+KG+S
Sbjct: 124 QTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSS 183

Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT 240
             V R+        ++Y ++ + L  A     D+P    +   AG     +A+P+DV+K+
Sbjct: 184 ALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKS 243

Query: 241 RYMNSALGQ--YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
           R      GQ  Y    HC +T +++EGPR  +KG + +  R    N+V+FV YE + R
Sbjct: 244 RLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAVLR 301



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 68/212 (32%), Positives = 93/212 (43%), Gaps = 21/212 (9%)

Query: 8   DVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQ---------GPVR------ 52
           D  PT     L    +  +   +T P + AKVRLQ Q ++Q         GP+       
Sbjct: 90  DAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCP 149

Query: 53  ---ATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQ-MSFASVRIGLYDSVKQFYT 108
              A    +YRG +  + T+ R EG   LY G  A + R   SFA+  +      +    
Sbjct: 150 VPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSP 209

Query: 109 KGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAR 168
            G     +   L+AG   G LA AVA P DV+K R QA  +  G RRY+  ++   T  R
Sbjct: 210 AGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQ--GQRRYRGLLHCMVTSVR 267

Query: 169 EEGFRGLWKGTSPNVARNAIVNCAELVTYDLI 200
           EEG R L+KG   N  R   VN    V Y+ +
Sbjct: 268 EEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAV 299



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 51/217 (23%), Positives = 72/217 (33%), Gaps = 38/217 (17%)

Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180
           +AG+  G   VAV  P D VKVR Q +       +Y    +  +     E   G ++G S
Sbjct: 4   VAGAIGGVCGVAVGYPLDTVKVRIQTEP------KYTGIWHCVRDTYHRERVWGFYRGLS 57

Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDD---LPCHFT-SAFGAGFCTTVIASPVD 236
             V   ++V+     TY      + +      D        T S   +G     + SP +
Sbjct: 58  LPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTE 117

Query: 237 VVKTRYMNSALGQ----------------------------YSSAGHCALTMLQKEGPRA 268
           V K R       Q                            Y    HC  T+ ++EG   
Sbjct: 118 VAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCG 177

Query: 269 FYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAACTSR 305
            YKG     LR G      F++Y  L   L  A  SR
Sbjct: 178 LYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSR 214



 Score = 32.0 bits (71), Expect = 0.71
 Identities = 19/74 (25%), Positives = 28/74 (37%), Gaps = 2/74 (2%)

Query: 218 FTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSF 277
           F +    G C   +  P+D VK R       +Y+   HC      +E    FY+G     
Sbjct: 3   FVAGAIGGVCGVAVGYPLDTVKVRIQTEP--KYTGIWHCVRDTYHRERVWGFYRGLSLPV 60

Query: 278 LRLGSWNVVMFVTY 291
             +   + V F TY
Sbjct: 61  CTVSLVSSVSFGTY 74


>gi|21389315 solute carrier family 25 (mitochondrial carrier;
           citrate transporter), member 1 precursor [Homo sapiens]
          Length = 311

 Score =  104 bits (260), Expect = 9e-23
 Identities = 79/284 (27%), Positives = 127/284 (44%), Gaps = 12/284 (4%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
           L  G A  I   ITFP +  K +LQ+   S  P       +YRG+   +   VR+ G   
Sbjct: 30  LAGGLAGGIEICITFPTEYVKTQLQLDERSHPP-------RYRGIGDCVRQTVRSHGVLG 82

Query: 78  LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTG-ALAVAVAQP 136
           LY GL + L   +  A+VR G+++ +                LL G   G A AV V  P
Sbjct: 83  LYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142

Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
            + +KV+F    +     +Y+   +  + I RE+G +G ++G +  V +           
Sbjct: 143 METIKVKF-IHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFV 201

Query: 197 YDLIKDALLKANLMTDDLPCHFTSAFGA--GFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
              +++     N      P   T  FGA  G  +    +P+DV+KTR       +Y +  
Sbjct: 202 MTSLRNWYRGDNPNKPMNPL-ITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTW 260

Query: 255 HCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
            C L +L+KEG +AFYKG +P   R+     ++FV Y+++ + L
Sbjct: 261 DCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 51/191 (26%), Positives = 88/191 (46%), Gaps = 15/191 (7%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
           LGAG A  +  ++  P++T KV+      S  P       +YRG    +  +VR +G + 
Sbjct: 129 LGAGVAEAV--VVVCPMETIKVKFIHDQTSPNP-------KYRGFFHGVREIVREQGLKG 179

Query: 78  LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLA--GSTTGALAVAVAQ 135
            Y GL A + +Q S  ++R  +  S++ +Y   + +  +   +    G+  GA +V    
Sbjct: 180 TYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNT 239

Query: 136 PTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195
           P DV+K R Q         +Y++T +    I ++EG +  +KGT P + R  +      V
Sbjct: 240 PLDVIKTRMQGLE----AHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFV 295

Query: 196 TYDLIKDALLK 206
            YD +   L K
Sbjct: 296 IYDEVVKLLNK 306



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 38/183 (20%), Positives = 77/183 (42%), Gaps = 6/183 (3%)

Query: 117 GSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLW 176
           G  +LAG   G + + +  PT+ VK + Q   R+    RY+   +  +   R  G  GL+
Sbjct: 26  GKAILAGGLAGGIEICITFPTEYVKTQLQLDERS-HPPRYRGIGDCVRQTVRSHGVLGLY 84

Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFC-TTVIASPV 235
           +G S  +  +          ++ + + +  A    D          GAG     V+  P+
Sbjct: 85  RGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTR-GLLCGLGAGVAEAVVVVCPM 143

Query: 236 DVVKTRYMN---SALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
           + +K ++++   S   +Y    H    +++++G +  Y+G   + L+ GS   + F    
Sbjct: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT 203

Query: 293 QLK 295
            L+
Sbjct: 204 SLR 206


>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
          Length = 298

 Score = 94.7 bits (234), Expect = 9e-20
 Identities = 74/297 (24%), Positives = 127/297 (42%), Gaps = 25/297 (8%)

Query: 17  FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76
           FL  G AA I+     P++  K+ LQ+Q  S+   +  A  QY+G++  I+ + + +G  
Sbjct: 12  FLAGGIAAAISKTAVAPIERVKLLLQVQHASK---QIAADKQYKGIVDCIVRIPKEQGVL 68

Query: 77  SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLLAGSTTGALAV 131
           S + G +A + R     ++     D  KQ +  G +  +         L +G   GA ++
Sbjct: 69  SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128

Query: 132 AVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVN 190
               P D  + R  A   ++G  R ++   +    I + +G RGL++G S +V    I  
Sbjct: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188

Query: 191 CAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIAS----PVDVVKTRYM--- 243
            A    YD  K       ++ D    H   ++      T +A     P D V+ R M   
Sbjct: 189 AAYFGVYDTAK------GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS 242

Query: 244 --NSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
               A   Y+    C   + + EG +AF+KG   + LR G     + V Y++LK+ +
Sbjct: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELKKVI 298



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)

Query: 15  VKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEG 74
           V ++ A T   +A ++++P DT + R+ +Q   +G     A   Y G +     + R EG
Sbjct: 212 VSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKG-----ADIMYTGTVDCWRKIFRDEG 266

Query: 75  PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQ 105
            ++ + G  + + R M  A V + LYD +K+
Sbjct: 267 GKAFFKGAWSNVLRGMGGAFVLV-LYDELKK 296


>gi|41462412 solute carrier family 25, member 35 [Homo sapiens]
          Length = 295

 Score = 94.7 bits (234), Expect = 9e-20
 Identities = 68/236 (28%), Positives = 105/236 (44%), Gaps = 11/236 (4%)

Query: 17  FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76
           FL +G AAC A + T PL+  K R+Q+QGE Q P   T    YR V    +T+ + +G  
Sbjct: 3   FLMSGLAACGACVFTNPLEVVKTRMQLQGELQAP--GTYQRHYRNVFHAFITIGKVDGLA 60

Query: 77  SLYNGLVAGLQRQMSFASVRIGLY---DSVKQFYTKGSEHASIGSRLLAGSTTGALAVAV 133
           +L  GL   L  Q     +R+G Y   ++    +T    H+   S   AG+  G +   +
Sbjct: 61  ALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARS-AAAGAMAGVMGAYL 119

Query: 134 AQPTDVVKVRFQAQARA----GGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189
             P  +VK   QAQA +    G   ++Q    A   I ++ G  GLW+G    + R  + 
Sbjct: 120 GSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVG 179

Query: 190 NCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMN 244
           +  +L T+   KD L +  +           +A  +G    +  +P DV  TR  N
Sbjct: 180 SSTQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYN 235


>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
           sapiens]
          Length = 675

 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 65/197 (32%), Positives = 94/197 (47%), Gaps = 14/197 (7%)

Query: 5   KATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMG 64
           K   VP  A +  L  G A     + T PL+  K+RLQ+ GE     R +A         
Sbjct: 422 KDGSVPLAAEI--LAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSA--------- 470

Query: 65  TILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGS 124
             L++VR  G   +Y G  A   R + F+++    Y  VK  +       S GS LLAG+
Sbjct: 471 --LSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGA 528

Query: 125 TTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVA 184
             G  A ++  P DV+K R Q  ARA G   Y   ++ ++ I REEG + LWKG    V 
Sbjct: 529 IAGMPAASLVTPADVIKTRLQVAARA-GQTTYSGVIDCFRKILREEGPKALWKGAGARVF 587

Query: 185 RNAIVNCAELVTYDLIK 201
           R++      L+TY+L++
Sbjct: 588 RSSPQFGVTLLTYELLQ 604



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 69/277 (24%), Positives = 113/277 (40%), Gaps = 12/277 (4%)

Query: 23  AACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGL 82
           A  +     +P+D  K R+Q Q  +   V       Y+        ++R EG   LY GL
Sbjct: 338 AGAVGATAVYPIDLVKTRMQNQRSTGSFV---GELMYKNSFDCFKKVLRYEGFFGLYRGL 394

Query: 83  VAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKV 142
           +  L       ++++ + D V+  +        + + +LAG   G   V    P ++VK+
Sbjct: 395 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKI 454

Query: 143 RFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKD 202
           R Q       G R  +      ++ R+ GF G++KG      R+   +      Y  +K 
Sbjct: 455 RLQVAGEITTGPRVSAL-----SVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKA 509

Query: 203 ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-LGQ--YSSAGHCALT 259
           +    +            A  AG     + +P DV+KTR   +A  GQ  YS    C   
Sbjct: 510 SFANEDGQVSPGSLLLAGAI-AGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK 568

Query: 260 MLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
           +L++EGP+A +KG      R      V  +TYE L+R
Sbjct: 569 ILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 605



 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 47/177 (26%), Positives = 81/177 (45%), Gaps = 7/177 (3%)

Query: 123 GSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLWKGT 179
           GS  GA+      P D+VK R Q Q   G   G   Y+++ + +K + R EGF GL++G 
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 394

Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239
            P +   A     +L   D ++D  +  +  +  L     +   AG    +  +P+++VK
Sbjct: 395 LPQLLGVAPEKAIKLTVNDFVRDKFMHKD-GSVPLAAEILAGGCAGGSQVIFTNPLEIVK 453

Query: 240 TRYMNSALGQYSSAGH-CALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295
            R      G+ ++     AL++++  G    YKG    FLR   ++ + F  Y  +K
Sbjct: 454 IRL--QVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVK 508



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 8/89 (8%)

Query: 19  GAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78
           GA      A L+T P D  K RLQ+   +           Y GV+     ++R EGP++L
Sbjct: 527 GAIAGMPAASLVT-PADVIKTRLQVAARA-------GQTTYSGVIDCFRKILREEGPKAL 578

Query: 79  YNGLVAGLQRQMSFASVRIGLYDSVKQFY 107
           + G  A + R      V +  Y+ +++++
Sbjct: 579 WKGAGARVFRSSPQFGVTLLTYELLQRWF 607


>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
           sapiens]
          Length = 676

 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 65/197 (32%), Positives = 94/197 (47%), Gaps = 14/197 (7%)

Query: 5   KATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMG 64
           K   VP  A +  L  G A     + T PL+  K+RLQ+ GE     R +A         
Sbjct: 423 KDGSVPLAAEI--LAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSA--------- 471

Query: 65  TILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGS 124
             L++VR  G   +Y G  A   R + F+++    Y  VK  +       S GS LLAG+
Sbjct: 472 --LSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGA 529

Query: 125 TTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVA 184
             G  A ++  P DV+K R Q  ARA G   Y   ++ ++ I REEG + LWKG    V 
Sbjct: 530 IAGMPAASLVTPADVIKTRLQVAARA-GQTTYSGVIDCFRKILREEGPKALWKGAGARVF 588

Query: 185 RNAIVNCAELVTYDLIK 201
           R++      L+TY+L++
Sbjct: 589 RSSPQFGVTLLTYELLQ 605



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 69/277 (24%), Positives = 113/277 (40%), Gaps = 12/277 (4%)

Query: 23  AACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGL 82
           A  +     +P+D  K R+Q Q  +   V       Y+        ++R EG   LY GL
Sbjct: 339 AGAVGATAVYPIDLVKTRMQNQRSTGSFV---GELMYKNSFDCFKKVLRYEGFFGLYRGL 395

Query: 83  VAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKV 142
           +  L       ++++ + D V+  +        + + +LAG   G   V    P ++VK+
Sbjct: 396 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKI 455

Query: 143 RFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKD 202
           R Q       G R  +      ++ R+ GF G++KG      R+   +      Y  +K 
Sbjct: 456 RLQVAGEITTGPRVSAL-----SVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKA 510

Query: 203 ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-LGQ--YSSAGHCALT 259
           +    +            A  AG     + +P DV+KTR   +A  GQ  YS    C   
Sbjct: 511 SFANEDGQVSPGSLLLAGAI-AGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK 569

Query: 260 MLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
           +L++EGP+A +KG      R      V  +TYE L+R
Sbjct: 570 ILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 606



 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 47/177 (26%), Positives = 81/177 (45%), Gaps = 7/177 (3%)

Query: 123 GSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLWKGT 179
           GS  GA+      P D+VK R Q Q   G   G   Y+++ + +K + R EGF GL++G 
Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 395

Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239
            P +   A     +L   D ++D  +  +  +  L     +   AG    +  +P+++VK
Sbjct: 396 LPQLLGVAPEKAIKLTVNDFVRDKFMHKD-GSVPLAAEILAGGCAGGSQVIFTNPLEIVK 454

Query: 240 TRYMNSALGQYSSAGH-CALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295
            R      G+ ++     AL++++  G    YKG    FLR   ++ + F  Y  +K
Sbjct: 455 IRL--QVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVK 509



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 8/89 (8%)

Query: 19  GAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78
           GA      A L+T P D  K RLQ+   +           Y GV+     ++R EGP++L
Sbjct: 528 GAIAGMPAASLVT-PADVIKTRLQVAARA-------GQTTYSGVIDCFRKILREEGPKAL 579

Query: 79  YNGLVAGLQRQMSFASVRIGLYDSVKQFY 107
           + G  A + R      V +  Y+ +++++
Sbjct: 580 WKGAGARVFRSSPQFGVTLLTYELLQRWF 608


>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
          Length = 298

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 73/305 (23%), Positives = 131/305 (42%), Gaps = 25/305 (8%)

Query: 7   TDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTI 66
           TD   +    FL  G AA I+     P++  K+ LQ+Q  S+   + TA  QY+G++  +
Sbjct: 2   TDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASK---QITADKQYKGIIDCV 58

Query: 67  LTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLL 121
           + + + +G  S + G +A + R     ++     D  KQ +  G +  +         L 
Sbjct: 59  VRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLA 118

Query: 122 AGSTTGALAVAVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180
           +G   GA ++    P D  + R  A   +AG  R ++   +    I + +G +GL++G +
Sbjct: 119 SGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFN 178

Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIAS----PVD 236
            +V    I   A    YD  K       ++ D    H   ++      T +A     P D
Sbjct: 179 VSVQGIIIYRAAYFGIYDTAK------GMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFD 232

Query: 237 VVKTRYMNSALGQ-----YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTY 291
            V+ R M  +  +     Y+    C   + + EG +AF+KG   + LR G     + V Y
Sbjct: 233 TVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR-GMGGAFVLVLY 291

Query: 292 EQLKR 296
           +++K+
Sbjct: 292 DEIKK 296



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 42/196 (21%), Positives = 70/196 (35%), Gaps = 12/196 (6%)

Query: 115 SIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQ---ARAGGGRRYQSTVNAYKTIAREEG 171
           S     LAG    A++     P + VK+  Q Q    +    ++Y+  ++    I +E+G
Sbjct: 7   SFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQG 66

Query: 172 FRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFT----SAFGAGFC 227
               W+G   NV R            D  K   L           +F     S   AG  
Sbjct: 67  VLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGAT 126

Query: 228 TTVIASPVDVVKTRYMNS-----ALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGS 282
           +     P+D  +TR         A  ++   G C + + + +G +  Y+GF  S   +  
Sbjct: 127 SLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIII 186

Query: 283 WNVVMFVTYEQLKRAL 298
           +    F  Y+  K  L
Sbjct: 187 YRAAYFGIYDTAKGML 202


>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
          Length = 320

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 32/293 (10%)

Query: 23  AACIADLIT----FPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78
           A  ++ L+T     P D  K+R Q+Q E     R+  SA+Y G++     +++ EGP + 
Sbjct: 21  AGSVSGLVTRALISPFDVIKIRFQLQHERLS--RSDPSAKYHGILQASRQILQEEGPTAF 78

Query: 79  YNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS--IGSRLLAGSTTGALAVAVAQP 136
           + G V      + + +V+   ++ + +   +GS + +       + G     +A     P
Sbjct: 79  WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138

Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
            DV++ RF AQ   G  + Y +  +A  T+ R EG +  +KG +P +         +   
Sbjct: 139 VDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195

Query: 197 YDLIKD-------ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTR-------Y 242
           Y  +K        A  K N    +L C      GAG  +  +  P+D+ K R       +
Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLC----GSGAGVISKTLTYPLDLFKKRLQVGGFEH 251

Query: 243 MNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
             +A GQ   Y     CA  +LQKEG   F+KG  PS L+       MF +YE
Sbjct: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 52/183 (28%), Positives = 93/183 (50%), Gaps = 10/183 (5%)

Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ----ARAGGGRRYQSTVNAYKTIAREEGFRGLW 176
           +AGS +G +  A+  P DV+K+RFQ Q    +R+    +Y   + A + I +EEG    W
Sbjct: 20  VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79

Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPV 235
           KG  P    +      + ++++++ + + + ++    +   HF     A    T+   PV
Sbjct: 80  KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139

Query: 236 DVVKTRYMNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
           DV++TR+  +A G+   Y++  H   TM + EGP+ FYKG  P+ + +  +  + F  Y 
Sbjct: 140 DVLRTRF--AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197

Query: 293 QLK 295
            LK
Sbjct: 198 SLK 200



 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 56/186 (30%), Positives = 91/186 (48%), Gaps = 21/186 (11%)

Query: 14  TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73
           +V F+  G AAC+A L   P+D  + R   QGE +          Y  +   + TM R+E
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPK---------VYNTLRHAVGTMYRSE 169

Query: 74  GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY-----TKGSEHASIGSRLLAGSTTGA 128
           GP+  Y GL   L     +A ++   Y S+K  Y      +G ++ ++   LL GS  G 
Sbjct: 170 GPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGV 228

Query: 129 LAVAVAQPTDVVKVRFQ------AQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPN 182
           ++  +  P D+ K R Q      A+A  G  RRY+  ++  K + ++EG  G +KG SP+
Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288

Query: 183 VARNAI 188
           + + A+
Sbjct: 289 LLKAAL 294


>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
          Length = 320

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 32/293 (10%)

Query: 23  AACIADLIT----FPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78
           A  ++ L+T     P D  K+R Q+Q E     R+  SA+Y G++     +++ EGP + 
Sbjct: 21  AGSVSGLVTRALISPFDVIKIRFQLQHERLS--RSDPSAKYHGILQASRQILQEEGPTAF 78

Query: 79  YNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS--IGSRLLAGSTTGALAVAVAQP 136
           + G V      + + +V+   ++ + +   +GS + +       + G     +A     P
Sbjct: 79  WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138

Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
            DV++ RF AQ   G  + Y +  +A  T+ R EG +  +KG +P +         +   
Sbjct: 139 VDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195

Query: 197 YDLIKD-------ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTR-------Y 242
           Y  +K        A  K N    +L C      GAG  +  +  P+D+ K R       +
Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLC----GSGAGVISKTLTYPLDLFKKRLQVGGFEH 251

Query: 243 MNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
             +A GQ   Y     CA  +LQKEG   F+KG  PS L+       MF +YE
Sbjct: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 52/183 (28%), Positives = 93/183 (50%), Gaps = 10/183 (5%)

Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ----ARAGGGRRYQSTVNAYKTIAREEGFRGLW 176
           +AGS +G +  A+  P DV+K+RFQ Q    +R+    +Y   + A + I +EEG    W
Sbjct: 20  VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79

Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPV 235
           KG  P    +      + ++++++ + + + ++    +   HF     A    T+   PV
Sbjct: 80  KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139

Query: 236 DVVKTRYMNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
           DV++TR+  +A G+   Y++  H   TM + EGP+ FYKG  P+ + +  +  + F  Y 
Sbjct: 140 DVLRTRF--AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197

Query: 293 QLK 295
            LK
Sbjct: 198 SLK 200



 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 56/186 (30%), Positives = 91/186 (48%), Gaps = 21/186 (11%)

Query: 14  TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73
           +V F+  G AAC+A L   P+D  + R   QGE +          Y  +   + TM R+E
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPK---------VYNTLRHAVGTMYRSE 169

Query: 74  GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY-----TKGSEHASIGSRLLAGSTTGA 128
           GP+  Y GL   L     +A ++   Y S+K  Y      +G ++ ++   LL GS  G 
Sbjct: 170 GPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGV 228

Query: 129 LAVAVAQPTDVVKVRFQ------AQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPN 182
           ++  +  P D+ K R Q      A+A  G  RRY+  ++  K + ++EG  G +KG SP+
Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288

Query: 183 VARNAI 188
           + + A+
Sbjct: 289 LLKAAL 294


>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
          Length = 320

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 32/293 (10%)

Query: 23  AACIADLIT----FPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78
           A  ++ L+T     P D  K+R Q+Q E     R+  SA+Y G++     +++ EGP + 
Sbjct: 21  AGSVSGLVTRALISPFDVIKIRFQLQHERLS--RSDPSAKYHGILQASRQILQEEGPTAF 78

Query: 79  YNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS--IGSRLLAGSTTGALAVAVAQP 136
           + G V      + + +V+   ++ + +   +GS + +       + G     +A     P
Sbjct: 79  WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138

Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
            DV++ RF AQ   G  + Y +  +A  T+ R EG +  +KG +P +         +   
Sbjct: 139 VDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195

Query: 197 YDLIKD-------ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTR-------Y 242
           Y  +K        A  K N    +L C      GAG  +  +  P+D+ K R       +
Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLC----GSGAGVISKTLTYPLDLFKKRLQVGGFEH 251

Query: 243 MNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
             +A GQ   Y     CA  +LQKEG   F+KG  PS L+       MF +YE
Sbjct: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 52/183 (28%), Positives = 93/183 (50%), Gaps = 10/183 (5%)

Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ----ARAGGGRRYQSTVNAYKTIAREEGFRGLW 176
           +AGS +G +  A+  P DV+K+RFQ Q    +R+    +Y   + A + I +EEG    W
Sbjct: 20  VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79

Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPV 235
           KG  P    +      + ++++++ + + + ++    +   HF     A    T+   PV
Sbjct: 80  KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139

Query: 236 DVVKTRYMNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
           DV++TR+  +A G+   Y++  H   TM + EGP+ FYKG  P+ + +  +  + F  Y 
Sbjct: 140 DVLRTRF--AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197

Query: 293 QLK 295
            LK
Sbjct: 198 SLK 200



 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 56/186 (30%), Positives = 91/186 (48%), Gaps = 21/186 (11%)

Query: 14  TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73
           +V F+  G AAC+A L   P+D  + R   QGE +          Y  +   + TM R+E
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPK---------VYNTLRHAVGTMYRSE 169

Query: 74  GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY-----TKGSEHASIGSRLLAGSTTGA 128
           GP+  Y GL   L     +A ++   Y S+K  Y      +G ++ ++   LL GS  G 
Sbjct: 170 GPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGV 228

Query: 129 LAVAVAQPTDVVKVRFQ------AQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPN 182
           ++  +  P D+ K R Q      A+A  G  RRY+  ++  K + ++EG  G +KG SP+
Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288

Query: 183 VARNAI 188
           + + A+
Sbjct: 289 LLKAAL 294


>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
          Length = 678

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 76/284 (26%), Positives = 115/284 (40%), Gaps = 12/284 (4%)

Query: 16  KFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGP 75
           +F     A  +     +P+D  K R+Q Q   +G         Y+        ++R EG 
Sbjct: 329 RFTLGSVAGAVGATAVYPIDLVKTRMQNQ---RGSGSVVGELMYKNSFDCFKKVLRYEGF 385

Query: 76  RSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQ 135
             LY GL+  L       ++++ + D V+  +T+      + + +LAG   G   V    
Sbjct: 386 FGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTN 445

Query: 136 PTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195
           P ++VK+R Q       G R  +       + R+ G  GL+KG      R+   +     
Sbjct: 446 PLEIVKIRLQVAGEITTGPRVSAL-----NVLRDLGIFGLYKGAKACFLRDIPFSAIYFP 500

Query: 196 TYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-LGQ--YSS 252
            Y   K  L   N     L      A  AG     + +P DV+KTR   +A  GQ  YS 
Sbjct: 501 VYAHCKLLLADENGHVGGLNLLAAGAM-AGVPAASLVTPADVIKTRLQVAARAGQTTYSG 559

Query: 253 AGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
              C   +L++EGP AF+KG      R      V  VTYE L+R
Sbjct: 560 VIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQR 603



 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 62/193 (32%), Positives = 90/193 (46%), Gaps = 14/193 (7%)

Query: 9   VPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILT 68
           VP  A V  L  G A     + T PL+  K+RLQ+ GE     R +A           L 
Sbjct: 424 VPLPAEV--LAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSA-----------LN 470

Query: 69  MVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGA 128
           ++R  G   LY G  A   R + F+++   +Y   K      + H    + L AG+  G 
Sbjct: 471 VLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGV 530

Query: 129 LAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAI 188
            A ++  P DV+K R Q  ARA G   Y   ++ ++ I REEG    WKGT+  V R++ 
Sbjct: 531 PAASLVTPADVIKTRLQVAARA-GQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSP 589

Query: 189 VNCAELVTYDLIK 201
                LVTY+L++
Sbjct: 590 QFGVTLVTYELLQ 602



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 51/184 (27%), Positives = 82/184 (44%), Gaps = 7/184 (3%)

Query: 119 RLLAGSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGL 175
           R   GS  GA+      P D+VK R Q Q  +G   G   Y+++ + +K + R EGF GL
Sbjct: 329 RFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGL 388

Query: 176 WKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPV 235
           ++G  P +   A     +L   D ++D   + +     LP    +   AG    +  +P+
Sbjct: 389 YRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVP-LPAEVLAGGCAGGSQVIFTNPL 447

Query: 236 DVVKTRYMNSALGQYSSAGHC-ALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294
           ++VK R      G+ ++     AL +L+  G    YKG    FLR   ++ + F  Y   
Sbjct: 448 EIVKIRLQ--VAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHC 505

Query: 295 KRAL 298
           K  L
Sbjct: 506 KLLL 509



 Score = 35.0 bits (79), Expect = 0.084
 Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 10/95 (10%)

Query: 15  VKFLGAGTAACI--ADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRT 72
           +  L AG  A +  A L+T P D  K RLQ+   +           Y GV+     ++R 
Sbjct: 519 LNLLAAGAMAGVPAASLVT-PADVIKTRLQVAARA-------GQTTYSGVIDCFRKILRE 570

Query: 73  EGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY 107
           EGP + + G  A + R      V +  Y+ +++++
Sbjct: 571 EGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWF 605


>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
          Length = 304

 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 71/280 (25%), Positives = 129/280 (46%), Gaps = 16/280 (5%)

Query: 17  FLGAGTAACIADLITFPLDTAKVRLQ-IQGESQGPVRATASAQYRGVMGTILTMVRTEGP 75
           FL    +   + L+  PLD  K RLQ +Q    G  R        G++  +L +VRTE  
Sbjct: 31  FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRV-------GMLAVLLKVVRTESL 83

Query: 76  RSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQ 135
             L+ G+   + R +    +  G   S+KQ++ +G    ++ S +L G  + ++A     
Sbjct: 84  LGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVML-GVGSRSVAGVCMS 142

Query: 136 PTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195
           P  V+K R+++     G   Y+S   A ++I   EG RGL+ G +  + R+A  +   L+
Sbjct: 143 PITVIKTRYES-----GKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLM 197

Query: 196 TYDLIKDALLKANLMTDDLP-CHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
            Y+  K+ +    +    +P  +F+    AG   +++  P DV+KT      L ++   G
Sbjct: 198 FYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPL-KFQWIG 256

Query: 255 HCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294
                + +  G R F++G +P  LR      + +  YE++
Sbjct: 257 QAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEM 296



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 7/177 (3%)

Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180
           L GS +G  +  + QP D++K R Q    +  G R    +     + R E   GLWKG S
Sbjct: 32  LCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMS 91

Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMT--DDLPCHFTSAFGAGFCTTVIASPVDVV 238
           P++ R          T   +K   L+ +  T  + +     S   AG C     SP+ V+
Sbjct: 92  PSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVC----MSPITVI 147

Query: 239 KTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295
           KTRY +   G Y S      ++   EG R  + G   + LR   ++ +  + Y Q K
Sbjct: 148 KTRYESGKYG-YESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTK 203


>gi|13775208 solute carrier family 25 (mitochondrial carrier;
           adenine nucleotide translocator), member 31 [Homo
           sapiens]
          Length = 315

 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 69/287 (24%), Positives = 127/287 (44%), Gaps = 15/287 (5%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
           L  G AA ++     P++  K+ LQ+Q  S+   + +  A+Y+G++  ++ + R +G  S
Sbjct: 25  LAGGVAAAVSKTAVAPIERVKLLLQVQASSK---QISPEARYKGMVDCLVRIPREQGFFS 81

Query: 78  LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLLAGSTTGALAVA 132
            + G +A + R     ++     D  KQ +  G            + L +G   GA ++ 
Sbjct: 82  FWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLC 141

Query: 133 VAQPTDVVKVRFQAQARAGGG-RRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNC 191
           V  P D  + R       G   R+++   +    IA+ +G  GL++G   +V    +   
Sbjct: 142 VVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYRA 201

Query: 192 AELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYM---NSALG 248
           +    YD +K  L K    T  L   F +      C+ +++ P D V+ R M     A  
Sbjct: 202 SYFGAYDTVKGLLPKPK-KTPFLVSFFIAQV-VTTCSGILSYPFDTVRRRMMMQSGEAKR 259

Query: 249 QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295
           QY     C + + Q EG  +F++G   + LR G+   ++ V Y+++K
Sbjct: 260 QYKGTLDCFVKIYQHEGISSFFRGAFSNVLR-GTGGALVLVLYDKIK 305



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 48/182 (26%), Positives = 84/182 (46%), Gaps = 8/182 (4%)

Query: 21  GTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYN 80
           G A   +  + +PLD A+ RL +    +GP       Q++G+   I+ + +++G   LY 
Sbjct: 133 GAAGATSLCVVYPLDFARTRLGVD-IGKGP----EERQFKGLGDCIMKIAKSDGIAGLYQ 187

Query: 81  GLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVV 140
           G    +Q  + + +   G YD+VK    K  +   + S  +A   T    + ++ P D V
Sbjct: 188 GFGVSVQGIIVYRASYFGAYDTVKGLLPKPKKTPFLVSFFIAQVVTTCSGI-LSYPFDTV 246

Query: 141 KVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLI 200
           + R   Q+     R+Y+ T++ +  I + EG    ++G   NV R        LV YD I
Sbjct: 247 RRRMMMQS-GEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGT-GGALVLVLYDKI 304

Query: 201 KD 202
           K+
Sbjct: 305 KE 306



 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 49/198 (24%), Positives = 77/198 (38%), Gaps = 14/198 (7%)

Query: 114 ASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARA---GGGRRYQSTVNAYKTIAREE 170
           +S G  LLAG    A++     P + VK+  Q QA +       RY+  V+    I RE+
Sbjct: 18  SSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQ 77

Query: 171 GFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALL----KANLMTDDLPCHFTSAFGAGF 226
           GF   W+G   NV R            D  K   +    K          +  S   AG 
Sbjct: 78  GFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGA 137

Query: 227 CTTVIASPVDVVKTRYMNSALG------QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRL 280
            +  +  P+D  +TR +   +G      Q+   G C + + + +G    Y+GF  S   +
Sbjct: 138 TSLCVVYPLDFARTR-LGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGI 196

Query: 281 GSWNVVMFVTYEQLKRAL 298
             +    F  Y+ +K  L
Sbjct: 197 IVYRASYFGAYDTVKGLL 214



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 28/105 (26%), Positives = 48/105 (45%), Gaps = 13/105 (12%)

Query: 15  VKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEG 74
           V F  A      + ++++P DT + R+ +Q          A  QY+G +   + + + EG
Sbjct: 224 VSFFIAQVVTTCSGILSYPFDTVRRRMMMQS-------GEAKRQYKGTLDCFVKIYQHEG 276

Query: 75  PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSR 119
             S + G  + + R    A V + LYD +K+F+     H  IG R
Sbjct: 277 ISSFFRGAFSNVLRGTGGALVLV-LYDKIKEFF-----HIDIGGR 315


>gi|55749577 solute carrier family 25 (mitochondrial carrier;
           adenine nucleotide translocator), member 4 [Homo
           sapiens]
          Length = 298

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 73/295 (24%), Positives = 126/295 (42%), Gaps = 25/295 (8%)

Query: 17  FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76
           FL  G AA ++     P++  K+ LQ+Q  S+   + +A  QY+G++  ++ + + +G  
Sbjct: 12  FLAGGVAAAVSKTAVAPIERVKLLLQVQHASK---QISAEKQYKGIIDCVVRIPKEQGFL 68

Query: 77  SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLLAGSTTGALAV 131
           S + G +A + R     ++     D  KQ +  G +            L +G   GA ++
Sbjct: 69  SFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSL 128

Query: 132 AVAQPTDVVKVRFQAQARAGGGRR-YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVN 190
               P D  + R  A    G  +R +    +    I + +G RGL++G + +V    I  
Sbjct: 129 CFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYR 188

Query: 191 CAELVTYDLIKDALLKANLMTDDLPCH-FTSAFGAGFCTTV---IASPVDVVKTRYM--- 243
            A    YD  K       ++ D    H F S   A   T V   ++ P D V+ R M   
Sbjct: 189 AAYFGVYDTAK------GMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQS 242

Query: 244 --NSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
               A   Y+    C   + + EG +AF+KG   + LR G     + V Y+++K+
Sbjct: 243 GRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLR-GMGGAFVLVLYDEIKK 296



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 43/190 (22%), Positives = 71/190 (37%), Gaps = 12/190 (6%)

Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ---ARAGGGRRYQSTVNAYKTIAREEGFRGLWK 177
           LAG    A++     P + VK+  Q Q    +    ++Y+  ++    I +E+GF   W+
Sbjct: 13  LAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWR 72

Query: 178 GTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFT----SAFGAGFCTTVIAS 233
           G   NV R            D  K   L           +F     S   AG  +     
Sbjct: 73  GNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVY 132

Query: 234 PVDVVKTRYM-----NSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMF 288
           P+D  +TR        +A  ++   G C + + + +G R  Y+GF  S   +  +    F
Sbjct: 133 PLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYF 192

Query: 289 VTYEQLKRAL 298
             Y+  K  L
Sbjct: 193 GVYDTAKGML 202



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 6/92 (6%)

Query: 15  VKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEG 74
           V ++ A +   +A L+++P DT + R+ +Q   +G     A   Y G +     + + EG
Sbjct: 212 VSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKG-----ADIMYTGTVDCWRKIAKDEG 266

Query: 75  PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQF 106
            ++ + G  + + R M  A V + LYD +K++
Sbjct: 267 AKAFFKGAWSNVLRGMGGAFVLV-LYDEIKKY 297


>gi|239755176 PREDICTED: similar to solute carrier family 25, member
           25 isoform 2 [Homo sapiens]
          Length = 469

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
           +  G A  ++   T PLD  KV +Q+       +         G++G    M+R  G RS
Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 241

Query: 78  LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137
           L+ G    + +    ++++   Y+ +K+      E   I  RL+AGS  GA+A +   P 
Sbjct: 242 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 301

Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197
           +V+K R  A  + G   +Y   ++  + I   EG    +KG  PN+         +L  Y
Sbjct: 302 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 357

Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
           + +K+A L+   +    P  F   A G  +  C  + + P+ +V+TR       Q S  G
Sbjct: 358 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 413

Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
              +TM       L+ EG    Y+G  P+F+++     + +V YE LK  L
Sbjct: 414 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 464



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%)

Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179
           L+AG   GA++     P D +KV  Q  A           V  +  + RE G R LW+G 
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 246

Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239
             NV + A  +  + + Y+ IK  L+ ++  T  +     +   AG        P++V+K
Sbjct: 247 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 305

Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
           TR      GQYS    CA  +L +EG  AFYKG++P+ L +  +  +    YE LK A
Sbjct: 306 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 363


>gi|239755174 PREDICTED: similar to solute carrier family 25, member
           25 isoform 1 [Homo sapiens]
          Length = 503

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
           +  G A  ++   T PLD  KV +Q+       +         G++G    M+R  G RS
Sbjct: 225 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 275

Query: 78  LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137
           L+ G    + +    ++++   Y+ +K+      E   I  RL+AGS  GA+A +   P 
Sbjct: 276 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 335

Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197
           +V+K R  A  + G   +Y   ++  + I   EG    +KG  PN+         +L  Y
Sbjct: 336 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 391

Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
           + +K+A L+   +    P  F   A G  +  C  + + P+ +V+TR       Q S  G
Sbjct: 392 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 447

Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
              +TM       L+ EG    Y+G  P+F+++     + +V YE LK  L
Sbjct: 448 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 498



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%)

Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179
           L+AG   GA++     P D +KV  Q  A           V  +  + RE G R LW+G 
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 280

Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239
             NV + A  +  + + Y+ IK  L+ ++  T  +     +   AG        P++V+K
Sbjct: 281 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 339

Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
           TR      GQYS    CA  +L +EG  AFYKG++P+ L +  +  +    YE LK A
Sbjct: 340 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 397


>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
           sapiens]
          Length = 489

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
           +  G A  ++   T PLD  KV +Q+       +         G++G    M+R  G RS
Sbjct: 211 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 261

Query: 78  LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137
           L+ G    + +    ++++   Y+ +K+      E   I  RL+AGS  GA+A +   P 
Sbjct: 262 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 321

Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197
           +V+K R  A  + G   +Y   ++  + I   EG    +KG  PN+         +L  Y
Sbjct: 322 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 377

Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
           + +K+A L+   +    P  F   A G  +  C  + + P+ +V+TR       Q S  G
Sbjct: 378 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 433

Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
              +TM       L+ EG    Y+G  P+F+++     + +V YE LK  L
Sbjct: 434 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 484



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%)

Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179
           L+AG   GA++     P D +KV  Q  A           V  +  + RE G R LW+G 
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 266

Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239
             NV + A  +  + + Y+ IK  L+ ++  T  +     +   AG        P++V+K
Sbjct: 267 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 325

Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
           TR      GQYS    CA  +L +EG  AFYKG++P+ L +  +  +    YE LK A
Sbjct: 326 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 383


>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
           sapiens]
          Length = 469

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
           +  G A  ++   T PLD  KV +Q+       +         G++G    M+R  G RS
Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 241

Query: 78  LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137
           L+ G    + +    ++++   Y+ +K+      E   I  RL+AGS  GA+A +   P 
Sbjct: 242 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 301

Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197
           +V+K R  A  + G   +Y   ++  + I   EG    +KG  PN+         +L  Y
Sbjct: 302 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 357

Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
           + +K+A L+   +    P  F   A G  +  C  + + P+ +V+TR       Q S  G
Sbjct: 358 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 413

Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
              +TM       L+ EG    Y+G  P+F+++     + +V YE LK  L
Sbjct: 414 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 464



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%)

Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179
           L+AG   GA++     P D +KV  Q  A           V  +  + RE G R LW+G 
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 246

Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239
             NV + A  +  + + Y+ IK  L+ ++  T  +     +   AG        P++V+K
Sbjct: 247 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 305

Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
           TR      GQYS    CA  +L +EG  AFYKG++P+ L +  +  +    YE LK A
Sbjct: 306 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 363


>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
           sapiens]
          Length = 366

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%)

Query: 18  LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
           +  G A  ++   T PLD  KV +Q+       +         G++G    M+R  G RS
Sbjct: 88  VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 138

Query: 78  LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137
           L+ G    + +    ++++   Y+ +K+      E   I  RL+AGS  GA+A +   P 
Sbjct: 139 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 198

Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197
           +V+K R  A  + G   +Y   ++  + I   EG    +KG  PN+         +L  Y
Sbjct: 199 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 254

Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
           + +K+A L+   +    P  F   A G  +  C  + + P+ +V+TR       Q S  G
Sbjct: 255 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 310

Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
              +TM       L+ EG    Y+G  P+F+++     + +V YE LK  L
Sbjct: 311 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 361



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%)

Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179
           L+AG   GA++     P D +KV  Q  A           V  +  + RE G R LW+G 
Sbjct: 87  LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 143

Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239
             NV + A  +  + + Y+ IK  L+ ++  T  +     +   AG        P++V+K
Sbjct: 144 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 202

Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
           TR      GQYS    CA  +L +EG  AFYKG++P+ L +  +  +    YE LK A
Sbjct: 203 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 260


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.133    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,280,541
Number of Sequences: 37866
Number of extensions: 385775
Number of successful extensions: 1360
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 726
Number of HSP's gapped (non-prelim): 205
length of query: 309
length of database: 18,247,518
effective HSP length: 102
effective length of query: 207
effective length of database: 14,385,186
effective search space: 2977733502
effective search space used: 2977733502
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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