BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|13259541 uncoupling protein 2 [Homo sapiens] (309 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|13259541 uncoupling protein 2 [Homo sapiens] 611 e-175 gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 445 e-125 gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 387 e-108 gi|11225256 uncoupling protein 1 [Homo sapiens] 354 5e-98 gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 201 9e-52 gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 199 2e-51 gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 199 2e-51 gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 181 7e-46 gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 167 8e-42 gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 158 7e-39 gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 132 4e-31 gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 105 5e-23 gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 104 9e-23 gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 95 9e-20 gi|41462412 solute carrier family 25, member 35 [Homo sapiens] 95 9e-20 gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 94 1e-19 gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 94 1e-19 gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 94 2e-19 gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 92 6e-19 gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 92 6e-19 gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 92 6e-19 gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 91 2e-18 gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 90 2e-18 gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 90 2e-18 gi|55749577 solute carrier family 25 (mitochondrial carrier; ade... 89 6e-18 gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 89 6e-18 gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 89 6e-18 gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 89 6e-18 gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 89 6e-18 gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 89 6e-18 >gi|13259541 uncoupling protein 2 [Homo sapiens] Length = 309 Score = 611 bits (1576), Expect = e-175 Identities = 309/309 (100%), Positives = 309/309 (100%) Query: 1 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR Sbjct: 1 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60 Query: 61 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL 120 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL Sbjct: 61 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL 120 Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS Sbjct: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180 Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT 240 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT Sbjct: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT 240 Query: 241 RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA 300 RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA Sbjct: 241 RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA 300 Query: 301 ACTSREAPF 309 ACTSREAPF Sbjct: 301 ACTSREAPF 309 >gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] Length = 312 Score = 445 bits (1144), Expect = e-125 Identities = 226/313 (72%), Positives = 257/313 (82%), Gaps = 5/313 (1%) Query: 1 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60 MVG K +DVPPT VKFLGAGTAAC ADL+TFPLDTAKVRLQIQGE+Q V+ QYR Sbjct: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQA-VQTARLVQYR 59 Query: 61 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYT-KGSEHASIGSR 119 GV+GTILTMVRTEGP S YNGLVAGLQRQMSFAS+RIGLYDSVKQ YT KG++++S+ +R Sbjct: 60 GVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTR 119 Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLW 176 +LAG TTGA+AV AQPTDVVKVRFQA G R+Y T++AY+TIAREEG RGLW Sbjct: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179 Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVD 236 KGT PN+ RNAIVNCAE+VTYD++K+ LL +L+TD+ PCHF SAFGAGFC TV+ASPVD Sbjct: 180 KGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVD 239 Query: 237 VVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 VVKTRYMNS GQY S C + M+ +EGP AFYKGF PSFLRLGSWNVVMFVTYEQLKR Sbjct: 240 VVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR 299 Query: 297 ALMAACTSREAPF 309 ALM RE+PF Sbjct: 300 ALMKVQMLRESPF 312 >gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] Length = 275 Score = 387 bits (993), Expect = e-108 Identities = 196/276 (71%), Positives = 226/276 (81%), Gaps = 5/276 (1%) Query: 1 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60 MVG K +DVPPT VKFLGAGTAAC ADL+TFPLDTAKVRLQIQGE+Q V+ QYR Sbjct: 1 MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQA-VQTARLVQYR 59 Query: 61 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYT-KGSEHASIGSR 119 GV+GTILTMVRTEGP S YNGLVAGLQRQMSFAS+RIGLYDSVKQ YT KG++++S+ +R Sbjct: 60 GVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTR 119 Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLW 176 +LAG TTGA+AV AQPTDVVKVRFQA G R+Y T++AY+TIAREEG RGLW Sbjct: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179 Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVD 236 KGT PN+ RNAIVNCAE+VTYD++K+ LL +L+TD+ PCHF SAFGAGFC TV+ASPVD Sbjct: 180 KGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVD 239 Query: 237 VVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKG 272 VVKTRYMNS GQY S C + M+ +EGP AFYKG Sbjct: 240 VVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKG 275 Score = 62.0 bits (149), Expect = 6e-10 Identities = 50/193 (25%), Positives = 72/193 (37%), Gaps = 12/193 (6%) Query: 119 RLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR-----RYQSTVNAYKTIAREEGFR 173 + L T A V P D KVR Q Q + +Y+ + T+ R EG Sbjct: 16 KFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPC 75 Query: 174 GLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIAS 233 + G + R + YD +K L + G A Sbjct: 76 SPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQ 135 Query: 234 PVDVVKTRYMNSA-LG------QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVV 286 P DVVK R+ S LG +YS T+ ++EG R +KG +P+ +R N Sbjct: 136 PTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA 195 Query: 287 MFVTYEQLKRALM 299 VTY+ LK L+ Sbjct: 196 EVVTYDILKEKLL 208 >gi|11225256 uncoupling protein 1 [Homo sapiens] Length = 307 Score = 354 bits (909), Expect = 5e-98 Identities = 178/300 (59%), Positives = 226/300 (75%), Gaps = 6/300 (2%) Query: 1 MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR 60 M G A+DV PT V+ AG AAC+AD+ITFPLDTAKVRLQ+QGE ++ +Y+ Sbjct: 1 MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECP----TSSVIRYK 56 Query: 61 GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHA-SIGSR 119 GV+GTI +V+TEG LY+GL AGLQRQ+S AS+RIGLYD+V++F T G E A S+GS+ Sbjct: 57 GVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSK 116 Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR-RYQSTVNAYKTIAREEGFRGLWKG 178 +LAG TTG +AV + QPT+VVKVR QAQ+ G + RY T NAY+ IA EG GLWKG Sbjct: 117 ILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKG 176 Query: 179 TSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVV 238 T+PN+ R+ I+NC ELVTYDL+K+A +K N++ DD+PCH SA AGFC T ++SPVDVV Sbjct: 177 TTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVV 236 Query: 239 KTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298 KTR++NS GQY S +CA+ + EGP AF+KG +PSFLRLGSWNV+MFV +EQLKR L Sbjct: 237 KTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKREL 296 Score = 67.4 bits (163), Expect = 2e-11 Identities = 54/206 (26%), Positives = 81/206 (39%), Gaps = 10/206 (4%) Query: 8 DVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTIL 67 + P+ K L T +A I P + KVRLQ Q G +Y G Sbjct: 108 ETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHG-----IKPRYTGTYNAYR 162 Query: 68 TMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-IGSRLLAGSTT 126 + TEG L+ G L R + + YD +K+ + K + A + L++ Sbjct: 163 IIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIA 222 Query: 127 GALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARN 186 G A A++ P DVVK RF +Y+S N + EG +KG P+ R Sbjct: 223 GFCATAMSSPVDVVKTRFINSPPG----QYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRL 278 Query: 187 AIVNCAELVTYDLIKDALLKANLMTD 212 N V ++ +K L K+ D Sbjct: 279 GSWNVIMFVCFEQLKRELSKSRQTMD 304 Score = 61.6 bits (148), Expect = 8e-10 Identities = 44/199 (22%), Positives = 74/199 (37%), Gaps = 7/199 (3%) Query: 108 TKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR--RYQSTVNAYKT 165 T H ++G +L + LA + P D KVR Q Q RY+ + Sbjct: 5 TASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITA 64 Query: 166 IAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAG 225 + + EG L+ G + R + YD +++ L L + G Sbjct: 65 VVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTG 124 Query: 226 FCTTVIASPVDVVKTR-----YMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRL 280 I P +VVK R +++ +Y+ + + EG +KG P+ +R Sbjct: 125 GVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRS 184 Query: 281 GSWNVVMFVTYEQLKRALM 299 N VTY+ +K A + Sbjct: 185 VIINCTELVTYDLMKEAFV 203 Score = 28.9 bits (63), Expect = 6.0 Identities = 24/107 (22%), Positives = 42/107 (39%), Gaps = 14/107 (13%) Query: 6 ATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGT 65 A DVP + A A A ++ P+D K R + QY+ V Sbjct: 209 ADDVP----CHLVSALIAGFCATAMSSPVDVVKTRFI----------NSPPGQYKSVPNC 254 Query: 66 ILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSE 112 + + EGP + + GLV R S+ + ++ +K+ +K + Sbjct: 255 AMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQ 301 >gi|58197562 solute carrier family 25, member 30 [Homo sapiens] Length = 291 Score = 201 bits (510), Expect = 9e-52 Identities = 109/286 (38%), Positives = 166/286 (58%), Gaps = 12/286 (4%) Query: 17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76 F+ G A+ A+ TFP+D K RLQIQG++ +YRG++ ++ + R EG + Sbjct: 9 FVYGGLASITAECGTFPIDLTKTRLQIQGQTNDA--KFKEIRYRGMLHALVRIGREEGLK 66 Query: 77 SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQP 136 +LY+G+ + RQ S+ +++IG Y S+K+ + + E ++ ++ G +G ++ +A P Sbjct: 67 ALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTIANP 126 Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196 TDV+K+R QAQ+ G + +N Y ++EG RGLWKG S R AIV EL Sbjct: 127 TDVLKIRMQAQSNTIQGGMIGNFMNIY----QQEGTRGLWKGVSLTAQRAAIVVGVELPV 182 Query: 197 YDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL------GQY 250 YD+ K L+ + LM D + HF S+F G + ++PVDVV+TR MN + Y Sbjct: 183 YDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCSGY 242 Query: 251 SSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 + C L + EG A YKGF P++LRLG WN++ FVTYEQLK+ Sbjct: 243 TGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKK 288 >gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo sapiens] Length = 325 Score = 199 bits (507), Expect = 2e-51 Identities = 107/285 (37%), Positives = 164/285 (57%), Gaps = 11/285 (3%) Query: 17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76 F+ G A+ +A+ TFP+D K RLQ+QG+S +YRG+ + + + EG Sbjct: 44 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDA--RFKEIKYRGMFHALFRICKEEGVL 101 Query: 77 SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQP 136 +LY+G+ L RQ S+ +++IG+Y S+K+ + + E ++ ++ G +G ++ +A P Sbjct: 102 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 161 Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196 TDV+K+R QAQ G S + ++ I ++EG RGLW+G P R AIV EL Sbjct: 162 TDVLKIRMQAQGSLFQG----SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPV 217 Query: 197 YDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-----LGQYS 251 YD+ K L+ + +M D + HF S+F G + ++PVDVV+TR MN + Y Sbjct: 218 YDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYK 277 Query: 252 SAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 L M + EG A YKGF P++LRLG WN++ F+TYEQLKR Sbjct: 278 GTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 322 Score = 69.7 bits (169), Expect = 3e-12 Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 12/192 (6%) Query: 12 TATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVR 71 T + + + I+ I P D K+R+Q QG S ++G+ + + + Sbjct: 140 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQG----------SLFQGSMIGSFIDIYQ 189 Query: 72 TEGPRSLYNGLVAGLQRQMSFASVRIGLYD-SVKQFYTKGSEHASIGSRLLAGSTTGALA 130 EG R L+ G+V QR V + +YD + K G +I + ++ T G Sbjct: 190 QEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAG 249 Query: 131 VAVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189 + P DVV+ R Q A G Y+ TV+ + + EGF L+KG PN R Sbjct: 250 ALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPW 309 Query: 190 NCAELVTYDLIK 201 N +TY+ +K Sbjct: 310 NIIFFITYEQLK 321 >gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo sapiens] Length = 322 Score = 199 bits (507), Expect = 2e-51 Identities = 107/285 (37%), Positives = 164/285 (57%), Gaps = 11/285 (3%) Query: 17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76 F+ G A+ +A+ TFP+D K RLQ+QG+S +YRG+ + + + EG Sbjct: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDA--RFKEIKYRGMFHALFRICKEEGVL 98 Query: 77 SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQP 136 +LY+G+ L RQ S+ +++IG+Y S+K+ + + E ++ ++ G +G ++ +A P Sbjct: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 158 Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196 TDV+K+R QAQ G S + ++ I ++EG RGLW+G P R AIV EL Sbjct: 159 TDVLKIRMQAQGSLFQG----SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPV 214 Query: 197 YDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-----LGQYS 251 YD+ K L+ + +M D + HF S+F G + ++PVDVV+TR MN + Y Sbjct: 215 YDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYK 274 Query: 252 SAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 L M + EG A YKGF P++LRLG WN++ F+TYEQLKR Sbjct: 275 GTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319 Score = 69.7 bits (169), Expect = 3e-12 Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 12/192 (6%) Query: 12 TATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVR 71 T + + + I+ I P D K+R+Q QG S ++G+ + + + Sbjct: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQG----------SLFQGSMIGSFIDIYQ 186 Query: 72 TEGPRSLYNGLVAGLQRQMSFASVRIGLYD-SVKQFYTKGSEHASIGSRLLAGSTTGALA 130 EG R L+ G+V QR V + +YD + K G +I + ++ T G Sbjct: 187 QEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAG 246 Query: 131 VAVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189 + P DVV+ R Q A G Y+ TV+ + + EGF L+KG PN R Sbjct: 247 ALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPW 306 Query: 190 NCAELVTYDLIK 201 N +TY+ +K Sbjct: 307 NIIFFITYEQLK 318 >gi|108860679 solute carrier family 25, member 27 [Homo sapiens] Length = 323 Score = 181 bits (459), Expect = 7e-46 Identities = 101/294 (34%), Positives = 166/294 (56%), Gaps = 14/294 (4%) Query: 16 KFLGAGTAACIADLITFPLDTAKVRLQIQGES---QGPVRATASAQYRGVMGTILTMVRT 72 KFL +G AA +A+L TFPLD K RLQ+QGE+ + A SA YRG++ T L ++ Sbjct: 22 KFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEE 81 Query: 73 EGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQ--FYTKGSEHASIGSRLLAGSTTGALA 130 EG L+ G+ + R + ++ R+ Y+ +++ F EH + ++ G G + Sbjct: 82 EGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIG 141 Query: 131 VAVAQPTDVVKVRFQAQARA---GGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNA 187 +A PTD+VKV+ Q + + G R++ +A+ I E G RGLW G PN+ R A Sbjct: 142 QFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAA 201 Query: 188 IVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL 247 +VN +L TYD +K L+ + D++ H S+ +G +++ +P DV+K+R MN Sbjct: 202 LVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPR 261 Query: 248 GQ------YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295 + Y S+ C + +Q EG + YKGF+PS+LR+ W++V ++TYE+++ Sbjct: 262 DKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIR 315 Score = 63.5 bits (153), Expect = 2e-10 Identities = 51/191 (26%), Positives = 87/191 (45%), Gaps = 12/191 (6%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQ---GPVRATASAQYRGVMGTILTMVRTEG 74 +G A I + P D KV++Q++G+ + P+R +RGV ++ G Sbjct: 132 IGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLR------FRGVHHAFAKILAEGG 185 Query: 75 PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSE-HASIGSRLLAGSTTGALAVAV 133 R L+ G V +QR + YD+VK + + +I + L+ +G +A + Sbjct: 186 IRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASIL 245 Query: 134 AQPTDVVKVRFQAQAR--AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNC 191 P DV+K R Q R G G Y+S+ + + EGF L+KG P+ R + Sbjct: 246 GTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSM 305 Query: 192 AELVTYDLIKD 202 +TY+ I++ Sbjct: 306 VFWLTYEKIRE 316 >gi|20149598 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 [Homo sapiens] Length = 287 Score = 167 bits (424), Expect = 8e-42 Identities = 106/279 (37%), Positives = 153/279 (54%), Gaps = 16/279 (5%) Query: 21 GTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYN 80 G A+C A T PLD KV LQ Q E + +R T G L +VRT+G +LY+ Sbjct: 14 GLASCGAACCTHPLDLLKVHLQTQQEVK--LRMT---------GMALRVVRTDGILALYS 62 Query: 81 GLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHA-SIGSRLLAGSTTGALAVAVAQPTDV 139 GL A L RQM+++ R +Y++V+ KGS+ ++L GS +G V P D+ Sbjct: 63 GLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADL 122 Query: 140 VKVRFQAQARAGGGRR--YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197 V VR Q + G+R Y ++ +AREEG R L+ G + +R A+V +L Y Sbjct: 123 VNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182 Query: 198 DLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCA 257 D K +L ++D++ HF ++F AG C T + P+DV+KTR MNS G+Y HCA Sbjct: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSK-GEYQGVFHCA 241 Query: 258 LTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 + K GP AFYKG +P+ +RL V+ FV EQL++ Sbjct: 242 VE-TAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279 >gi|21361114 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 [Homo sapiens] Length = 314 Score = 158 bits (399), Expect = 7e-39 Identities = 97/292 (33%), Positives = 151/292 (51%), Gaps = 15/292 (5%) Query: 14 TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73 +VKFL G A A + PLD K R+Q+ GE + +Y+ + ++++ E Sbjct: 22 SVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEG------AKTREYKTSFHALTSILKAE 75 Query: 74 GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLA--GSTTGALAV 131 G R +Y GL AGL RQ ++ + R+G+Y + + T G++ G L A G T GA Sbjct: 76 GLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLT-GADGTPPGFLLKAVIGMTAGATGA 134 Query: 132 AVAQPTDVVKVRFQAQARAGGGRR--YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189 V P +V +R A R +R Y++ NA I REEG LW+G P +AR +V Sbjct: 135 FVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVV 194 Query: 190 NCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL-- 247 N A+L +Y K LL + +D++ CHF ++ +G TT + PVD+ KTR N + Sbjct: 195 NAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMID 254 Query: 248 --GQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297 +Y + +++ EG + +KGF P + RLG V+ F+ EQ+ +A Sbjct: 255 GKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKA 306 Score = 62.0 bits (149), Expect = 6e-10 Identities = 45/189 (23%), Positives = 78/189 (41%), Gaps = 10/189 (5%) Query: 119 RLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKG 178 + L G G A QP D+VK R Q R Y+++ +A +I + EG RG++ G Sbjct: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83 Query: 179 TSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVV 238 S + R A L Y ++ + L A+ AG + +P +V Sbjct: 84 LSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVA 143 Query: 239 KTRYMNSALGQ--------YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVT 290 R +A G+ Y + + + + ++EG ++G +P+ R N + Sbjct: 144 LIRM--TADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLAS 201 Query: 291 YEQLKRALM 299 Y Q K+ L+ Sbjct: 202 YSQSKQFLL 210 >gi|46409330 solute carrier family 25, member 34 [Homo sapiens] Length = 304 Score = 132 bits (332), Expect = 4e-31 Identities = 96/302 (31%), Positives = 147/302 (48%), Gaps = 25/302 (8%) Query: 9 VPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILT 68 VPP + LGA +A C+A + T PL+ K RLQ+QGE Q R T Y G + ++ Sbjct: 4 VPPAVDL-VLGA-SACCLACVFTNPLEVVKTRLQLQGELQA--RGTYPRPYHGFIASVAA 59 Query: 69 MVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGA 128 + R +G L GL AGL Q VR Y Q G ++AG+ GA Sbjct: 60 VARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ----AGLTQQPGGTVVAGAVAGA 115 Query: 129 LAVAVAQPTDVVKVRFQAQARA----GGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVA 184 L V P ++K + QAQ A G +Q+ + A +TI R++G GLW+G V Sbjct: 116 LGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVP 175 Query: 185 RNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTT----VIASPVDVVKT 240 R + + A+L T+ K + K + +D + A G ++ V+ +P DVV T Sbjct: 176 RVMVGSAAQLATFASAKAWVQKQQWLPED---SWLVALAGGMISSIAVVVVMTPFDVVST 232 Query: 241 RYMNSAL-----GQ-YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294 R N + GQ Y C + + ++EGP A YKG P++LRLG ++ + +++L Sbjct: 233 RLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDEL 292 Query: 295 KR 296 ++ Sbjct: 293 RK 294 >gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] Length = 308 Score = 105 bits (262), Expect = 5e-23 Identities = 81/298 (27%), Positives = 128/298 (42%), Gaps = 43/298 (14%) Query: 30 ITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGL-----VA 84 + +PLDT KVR+Q + +Y G+ + E Y GL Sbjct: 16 VGYPLDTVKVRIQTE------------PKYTGIWHCVRDTYHRERVWGFYRGLSLPVCTV 63 Query: 85 GLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRF 144 L +SF + R L + Y + L+G +G + V + PT+V KVR Sbjct: 64 SLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRL 123 Query: 145 QAQARAGGGRR------------------------YQSTVNAYKTIAREEGFRGLWKGTS 180 Q Q +A +R Y+ ++ T+AREEG GL+KG+S Sbjct: 124 QTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSS 183 Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT 240 V R+ ++Y ++ + L A D+P + AG +A+P+DV+K+ Sbjct: 184 ALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKS 243 Query: 241 RYMNSALGQ--YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 R GQ Y HC +T +++EGPR +KG + + R N+V+FV YE + R Sbjct: 244 RLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAVLR 301 Score = 83.6 bits (205), Expect = 2e-16 Identities = 68/212 (32%), Positives = 93/212 (43%), Gaps = 21/212 (9%) Query: 8 DVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQ---------GPVR------ 52 D PT L + + +T P + AKVRLQ Q ++Q GP+ Sbjct: 90 DAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCP 149 Query: 53 ---ATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQ-MSFASVRIGLYDSVKQFYT 108 A +YRG + + T+ R EG LY G A + R SFA+ + + Sbjct: 150 VPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSP 209 Query: 109 KGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAR 168 G + L+AG G LA AVA P DV+K R QA + G RRY+ ++ T R Sbjct: 210 AGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQ--GQRRYRGLLHCMVTSVR 267 Query: 169 EEGFRGLWKGTSPNVARNAIVNCAELVTYDLI 200 EEG R L+KG N R VN V Y+ + Sbjct: 268 EEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAV 299 Score = 43.9 bits (102), Expect = 2e-04 Identities = 51/217 (23%), Positives = 72/217 (33%), Gaps = 38/217 (17%) Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180 +AG+ G VAV P D VKVR Q + +Y + + E G ++G S Sbjct: 4 VAGAIGGVCGVAVGYPLDTVKVRIQTEP------KYTGIWHCVRDTYHRERVWGFYRGLS 57 Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDD---LPCHFT-SAFGAGFCTTVIASPVD 236 V ++V+ TY + + D T S +G + SP + Sbjct: 58 LPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTE 117 Query: 237 VVKTRYMNSALGQ----------------------------YSSAGHCALTMLQKEGPRA 268 V K R Q Y HC T+ ++EG Sbjct: 118 VAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCG 177 Query: 269 FYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAACTSR 305 YKG LR G F++Y L L A SR Sbjct: 178 LYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSR 214 Score = 32.0 bits (71), Expect = 0.71 Identities = 19/74 (25%), Positives = 28/74 (37%), Gaps = 2/74 (2%) Query: 218 FTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSF 277 F + G C + P+D VK R +Y+ HC +E FY+G Sbjct: 3 FVAGAIGGVCGVAVGYPLDTVKVRIQTEP--KYTGIWHCVRDTYHRERVWGFYRGLSLPV 60 Query: 278 LRLGSWNVVMFVTY 291 + + V F TY Sbjct: 61 CTVSLVSSVSFGTY 74 >gi|21389315 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 precursor [Homo sapiens] Length = 311 Score = 104 bits (260), Expect = 9e-23 Identities = 79/284 (27%), Positives = 127/284 (44%), Gaps = 12/284 (4%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77 L G A I ITFP + K +LQ+ S P +YRG+ + VR+ G Sbjct: 30 LAGGLAGGIEICITFPTEYVKTQLQLDERSHPP-------RYRGIGDCVRQTVRSHGVLG 82 Query: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTG-ALAVAVAQP 136 LY GL + L + A+VR G+++ + LL G G A AV V P Sbjct: 83 LYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142 Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196 + +KV+F + +Y+ + + I RE+G +G ++G + V + Sbjct: 143 METIKVKF-IHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFV 201 Query: 197 YDLIKDALLKANLMTDDLPCHFTSAFGA--GFCTTVIASPVDVVKTRYMNSALGQYSSAG 254 +++ N P T FGA G + +P+DV+KTR +Y + Sbjct: 202 MTSLRNWYRGDNPNKPMNPL-ITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTW 260 Query: 255 HCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298 C L +L+KEG +AFYKG +P R+ ++FV Y+++ + L Sbjct: 261 DCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304 Score = 69.3 bits (168), Expect = 4e-12 Identities = 51/191 (26%), Positives = 88/191 (46%), Gaps = 15/191 (7%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77 LGAG A + ++ P++T KV+ S P +YRG + +VR +G + Sbjct: 129 LGAGVAEAV--VVVCPMETIKVKFIHDQTSPNP-------KYRGFFHGVREIVREQGLKG 179 Query: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLA--GSTTGALAVAVAQ 135 Y GL A + +Q S ++R + S++ +Y + + + + G+ GA +V Sbjct: 180 TYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNT 239 Query: 136 PTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195 P DV+K R Q +Y++T + I ++EG + +KGT P + R + V Sbjct: 240 PLDVIKTRMQGLE----AHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFV 295 Query: 196 TYDLIKDALLK 206 YD + L K Sbjct: 296 IYDEVVKLLNK 306 Score = 50.8 bits (120), Expect = 1e-06 Identities = 38/183 (20%), Positives = 77/183 (42%), Gaps = 6/183 (3%) Query: 117 GSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLW 176 G +LAG G + + + PT+ VK + Q R+ RY+ + + R G GL+ Sbjct: 26 GKAILAGGLAGGIEICITFPTEYVKTQLQLDERS-HPPRYRGIGDCVRQTVRSHGVLGLY 84 Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFC-TTVIASPV 235 +G S + + ++ + + + A D GAG V+ P+ Sbjct: 85 RGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTR-GLLCGLGAGVAEAVVVVCPM 143 Query: 236 DVVKTRYMN---SALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292 + +K ++++ S +Y H +++++G + Y+G + L+ GS + F Sbjct: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT 203 Query: 293 QLK 295 L+ Sbjct: 204 SLR 206 >gi|156071462 solute carrier family 25, member A6 [Homo sapiens] Length = 298 Score = 94.7 bits (234), Expect = 9e-20 Identities = 74/297 (24%), Positives = 127/297 (42%), Gaps = 25/297 (8%) Query: 17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76 FL G AA I+ P++ K+ LQ+Q S+ + A QY+G++ I+ + + +G Sbjct: 12 FLAGGIAAAISKTAVAPIERVKLLLQVQHASK---QIAADKQYKGIVDCIVRIPKEQGVL 68 Query: 77 SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLLAGSTTGALAV 131 S + G +A + R ++ D KQ + G + + L +G GA ++ Sbjct: 69 SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSL 128 Query: 132 AVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVN 190 P D + R A ++G R ++ + I + +G RGL++G S +V I Sbjct: 129 CFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188 Query: 191 CAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIAS----PVDVVKTRYM--- 243 A YD K ++ D H ++ T +A P D V+ R M Sbjct: 189 AAYFGVYDTAK------GMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQS 242 Query: 244 --NSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298 A Y+ C + + EG +AF+KG + LR G + V Y++LK+ + Sbjct: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELKKVI 298 Score = 41.2 bits (95), Expect = 0.001 Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%) Query: 15 VKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEG 74 V ++ A T +A ++++P DT + R+ +Q +G A Y G + + R EG Sbjct: 212 VSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKG-----ADIMYTGTVDCWRKIFRDEG 266 Query: 75 PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQ 105 ++ + G + + R M A V + LYD +K+ Sbjct: 267 GKAFFKGAWSNVLRGMGGAFVLV-LYDELKK 296 >gi|41462412 solute carrier family 25, member 35 [Homo sapiens] Length = 295 Score = 94.7 bits (234), Expect = 9e-20 Identities = 68/236 (28%), Positives = 105/236 (44%), Gaps = 11/236 (4%) Query: 17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76 FL +G AAC A + T PL+ K R+Q+QGE Q P T YR V +T+ + +G Sbjct: 3 FLMSGLAACGACVFTNPLEVVKTRMQLQGELQAP--GTYQRHYRNVFHAFITIGKVDGLA 60 Query: 77 SLYNGLVAGLQRQMSFASVRIGLY---DSVKQFYTKGSEHASIGSRLLAGSTTGALAVAV 133 +L GL L Q +R+G Y ++ +T H+ S AG+ G + + Sbjct: 61 ALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARS-AAAGAMAGVMGAYL 119 Query: 134 AQPTDVVKVRFQAQARA----GGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189 P +VK QAQA + G ++Q A I ++ G GLW+G + R + Sbjct: 120 GSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVG 179 Query: 190 NCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMN 244 + +L T+ KD L + + +A +G + +P DV TR N Sbjct: 180 SSTQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYN 235 >gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo sapiens] Length = 675 Score = 94.4 bits (233), Expect = 1e-19 Identities = 65/197 (32%), Positives = 94/197 (47%), Gaps = 14/197 (7%) Query: 5 KATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMG 64 K VP A + L G A + T PL+ K+RLQ+ GE R +A Sbjct: 422 KDGSVPLAAEI--LAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSA--------- 470 Query: 65 TILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGS 124 L++VR G +Y G A R + F+++ Y VK + S GS LLAG+ Sbjct: 471 --LSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGA 528 Query: 125 TTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVA 184 G A ++ P DV+K R Q ARA G Y ++ ++ I REEG + LWKG V Sbjct: 529 IAGMPAASLVTPADVIKTRLQVAARA-GQTTYSGVIDCFRKILREEGPKALWKGAGARVF 587 Query: 185 RNAIVNCAELVTYDLIK 201 R++ L+TY+L++ Sbjct: 588 RSSPQFGVTLLTYELLQ 604 Score = 83.2 bits (204), Expect = 3e-16 Identities = 69/277 (24%), Positives = 113/277 (40%), Gaps = 12/277 (4%) Query: 23 AACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGL 82 A + +P+D K R+Q Q + V Y+ ++R EG LY GL Sbjct: 338 AGAVGATAVYPIDLVKTRMQNQRSTGSFV---GELMYKNSFDCFKKVLRYEGFFGLYRGL 394 Query: 83 VAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKV 142 + L ++++ + D V+ + + + +LAG G V P ++VK+ Sbjct: 395 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKI 454 Query: 143 RFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKD 202 R Q G R + ++ R+ GF G++KG R+ + Y +K Sbjct: 455 RLQVAGEITTGPRVSAL-----SVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKA 509 Query: 203 ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-LGQ--YSSAGHCALT 259 + + A AG + +P DV+KTR +A GQ YS C Sbjct: 510 SFANEDGQVSPGSLLLAGAI-AGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK 568 Query: 260 MLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 +L++EGP+A +KG R V +TYE L+R Sbjct: 569 ILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 605 Score = 65.1 bits (157), Expect = 8e-11 Identities = 47/177 (26%), Positives = 81/177 (45%), Gaps = 7/177 (3%) Query: 123 GSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLWKGT 179 GS GA+ P D+VK R Q Q G G Y+++ + +K + R EGF GL++G Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 394 Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239 P + A +L D ++D + + + L + AG + +P+++VK Sbjct: 395 LPQLLGVAPEKAIKLTVNDFVRDKFMHKD-GSVPLAAEILAGGCAGGSQVIFTNPLEIVK 453 Query: 240 TRYMNSALGQYSSAGH-CALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295 R G+ ++ AL++++ G YKG FLR ++ + F Y +K Sbjct: 454 IRL--QVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVK 508 Score = 34.7 bits (78), Expect = 0.11 Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 8/89 (8%) Query: 19 GAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78 GA A L+T P D K RLQ+ + Y GV+ ++R EGP++L Sbjct: 527 GAIAGMPAASLVT-PADVIKTRLQVAARA-------GQTTYSGVIDCFRKILREEGPKAL 578 Query: 79 YNGLVAGLQRQMSFASVRIGLYDSVKQFY 107 + G A + R V + Y+ +++++ Sbjct: 579 WKGAGARVFRSSPQFGVTLLTYELLQRWF 607 >gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo sapiens] Length = 676 Score = 94.4 bits (233), Expect = 1e-19 Identities = 65/197 (32%), Positives = 94/197 (47%), Gaps = 14/197 (7%) Query: 5 KATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMG 64 K VP A + L G A + T PL+ K+RLQ+ GE R +A Sbjct: 423 KDGSVPLAAEI--LAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSA--------- 471 Query: 65 TILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGS 124 L++VR G +Y G A R + F+++ Y VK + S GS LLAG+ Sbjct: 472 --LSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGA 529 Query: 125 TTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVA 184 G A ++ P DV+K R Q ARA G Y ++ ++ I REEG + LWKG V Sbjct: 530 IAGMPAASLVTPADVIKTRLQVAARA-GQTTYSGVIDCFRKILREEGPKALWKGAGARVF 588 Query: 185 RNAIVNCAELVTYDLIK 201 R++ L+TY+L++ Sbjct: 589 RSSPQFGVTLLTYELLQ 605 Score = 83.2 bits (204), Expect = 3e-16 Identities = 69/277 (24%), Positives = 113/277 (40%), Gaps = 12/277 (4%) Query: 23 AACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGL 82 A + +P+D K R+Q Q + V Y+ ++R EG LY GL Sbjct: 339 AGAVGATAVYPIDLVKTRMQNQRSTGSFV---GELMYKNSFDCFKKVLRYEGFFGLYRGL 395 Query: 83 VAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKV 142 + L ++++ + D V+ + + + +LAG G V P ++VK+ Sbjct: 396 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKI 455 Query: 143 RFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKD 202 R Q G R + ++ R+ GF G++KG R+ + Y +K Sbjct: 456 RLQVAGEITTGPRVSAL-----SVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKA 510 Query: 203 ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-LGQ--YSSAGHCALT 259 + + A AG + +P DV+KTR +A GQ YS C Sbjct: 511 SFANEDGQVSPGSLLLAGAI-AGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK 569 Query: 260 MLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 +L++EGP+A +KG R V +TYE L+R Sbjct: 570 ILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 606 Score = 65.1 bits (157), Expect = 8e-11 Identities = 47/177 (26%), Positives = 81/177 (45%), Gaps = 7/177 (3%) Query: 123 GSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGLWKGT 179 GS GA+ P D+VK R Q Q G G Y+++ + +K + R EGF GL++G Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 395 Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239 P + A +L D ++D + + + L + AG + +P+++VK Sbjct: 396 LPQLLGVAPEKAIKLTVNDFVRDKFMHKD-GSVPLAAEILAGGCAGGSQVIFTNPLEIVK 454 Query: 240 TRYMNSALGQYSSAGH-CALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295 R G+ ++ AL++++ G YKG FLR ++ + F Y +K Sbjct: 455 IRL--QVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVK 509 Score = 34.7 bits (78), Expect = 0.11 Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 8/89 (8%) Query: 19 GAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78 GA A L+T P D K RLQ+ + Y GV+ ++R EGP++L Sbjct: 528 GAIAGMPAASLVT-PADVIKTRLQVAARA-------GQTTYSGVIDCFRKILREEGPKAL 579 Query: 79 YNGLVAGLQRQMSFASVRIGLYDSVKQFY 107 + G A + R V + Y+ +++++ Sbjct: 580 WKGAGARVFRSSPQFGVTLLTYELLQRWF 608 >gi|156071459 solute carrier family 25, member 5 [Homo sapiens] Length = 298 Score = 94.0 bits (232), Expect = 2e-19 Identities = 73/305 (23%), Positives = 131/305 (42%), Gaps = 25/305 (8%) Query: 7 TDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTI 66 TD + FL G AA I+ P++ K+ LQ+Q S+ + TA QY+G++ + Sbjct: 2 TDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASK---QITADKQYKGIIDCV 58 Query: 67 LTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLL 121 + + + +G S + G +A + R ++ D KQ + G + + L Sbjct: 59 VRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLA 118 Query: 122 AGSTTGALAVAVAQPTDVVKVRFQAQ-ARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180 +G GA ++ P D + R A +AG R ++ + I + +G +GL++G + Sbjct: 119 SGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFN 178 Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIAS----PVD 236 +V I A YD K ++ D H ++ T +A P D Sbjct: 179 VSVQGIIIYRAAYFGIYDTAK------GMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFD 232 Query: 237 VVKTRYMNSALGQ-----YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTY 291 V+ R M + + Y+ C + + EG +AF+KG + LR G + V Y Sbjct: 233 TVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR-GMGGAFVLVLY 291 Query: 292 EQLKR 296 +++K+ Sbjct: 292 DEIKK 296 Score = 48.9 bits (115), Expect = 6e-06 Identities = 42/196 (21%), Positives = 70/196 (35%), Gaps = 12/196 (6%) Query: 115 SIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQ---ARAGGGRRYQSTVNAYKTIAREEG 171 S LAG A++ P + VK+ Q Q + ++Y+ ++ I +E+G Sbjct: 7 SFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQG 66 Query: 172 FRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFT----SAFGAGFC 227 W+G NV R D K L +F S AG Sbjct: 67 VLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGAT 126 Query: 228 TTVIASPVDVVKTRYMNS-----ALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGS 282 + P+D +TR A ++ G C + + + +G + Y+GF S + Sbjct: 127 SLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIII 186 Query: 283 WNVVMFVTYEQLKRAL 298 + F Y+ K L Sbjct: 187 YRAAYFGIYDTAKGML 202 >gi|186928856 solute carrier family 25, member 19 [Homo sapiens] Length = 320 Score = 92.0 bits (227), Expect = 6e-19 Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 32/293 (10%) Query: 23 AACIADLIT----FPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78 A ++ L+T P D K+R Q+Q E R+ SA+Y G++ +++ EGP + Sbjct: 21 AGSVSGLVTRALISPFDVIKIRFQLQHERLS--RSDPSAKYHGILQASRQILQEEGPTAF 78 Query: 79 YNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS--IGSRLLAGSTTGALAVAVAQP 136 + G V + + +V+ ++ + + +GS + + + G +A P Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138 Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196 DV++ RF AQ G + Y + +A T+ R EG + +KG +P + + Sbjct: 139 VDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195 Query: 197 YDLIKD-------ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTR-------Y 242 Y +K A K N +L C GAG + + P+D+ K R + Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLC----GSGAGVISKTLTYPLDLFKKRLQVGGFEH 251 Query: 243 MNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292 +A GQ Y CA +LQKEG F+KG PS L+ MF +YE Sbjct: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304 Score = 87.4 bits (215), Expect = 1e-17 Identities = 52/183 (28%), Positives = 93/183 (50%), Gaps = 10/183 (5%) Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ----ARAGGGRRYQSTVNAYKTIAREEGFRGLW 176 +AGS +G + A+ P DV+K+RFQ Q +R+ +Y + A + I +EEG W Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79 Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPV 235 KG P + + ++++++ + + + ++ + HF A T+ PV Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139 Query: 236 DVVKTRYMNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292 DV++TR+ +A G+ Y++ H TM + EGP+ FYKG P+ + + + + F Y Sbjct: 140 DVLRTRF--AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197 Query: 293 QLK 295 LK Sbjct: 198 SLK 200 Score = 86.3 bits (212), Expect = 3e-17 Identities = 56/186 (30%), Positives = 91/186 (48%), Gaps = 21/186 (11%) Query: 14 TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73 +V F+ G AAC+A L P+D + R QGE + Y + + TM R+E Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPK---------VYNTLRHAVGTMYRSE 169 Query: 74 GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY-----TKGSEHASIGSRLLAGSTTGA 128 GP+ Y GL L +A ++ Y S+K Y +G ++ ++ LL GS G Sbjct: 170 GPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGV 228 Query: 129 LAVAVAQPTDVVKVRFQ------AQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPN 182 ++ + P D+ K R Q A+A G RRY+ ++ K + ++EG G +KG SP+ Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288 Query: 183 VARNAI 188 + + A+ Sbjct: 289 LLKAAL 294 >gi|186928860 solute carrier family 25, member 19 [Homo sapiens] Length = 320 Score = 92.0 bits (227), Expect = 6e-19 Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 32/293 (10%) Query: 23 AACIADLIT----FPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78 A ++ L+T P D K+R Q+Q E R+ SA+Y G++ +++ EGP + Sbjct: 21 AGSVSGLVTRALISPFDVIKIRFQLQHERLS--RSDPSAKYHGILQASRQILQEEGPTAF 78 Query: 79 YNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS--IGSRLLAGSTTGALAVAVAQP 136 + G V + + +V+ ++ + + +GS + + + G +A P Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138 Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196 DV++ RF AQ G + Y + +A T+ R EG + +KG +P + + Sbjct: 139 VDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195 Query: 197 YDLIKD-------ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTR-------Y 242 Y +K A K N +L C GAG + + P+D+ K R + Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLC----GSGAGVISKTLTYPLDLFKKRLQVGGFEH 251 Query: 243 MNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292 +A GQ Y CA +LQKEG F+KG PS L+ MF +YE Sbjct: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304 Score = 87.4 bits (215), Expect = 1e-17 Identities = 52/183 (28%), Positives = 93/183 (50%), Gaps = 10/183 (5%) Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ----ARAGGGRRYQSTVNAYKTIAREEGFRGLW 176 +AGS +G + A+ P DV+K+RFQ Q +R+ +Y + A + I +EEG W Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79 Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPV 235 KG P + + ++++++ + + + ++ + HF A T+ PV Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139 Query: 236 DVVKTRYMNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292 DV++TR+ +A G+ Y++ H TM + EGP+ FYKG P+ + + + + F Y Sbjct: 140 DVLRTRF--AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197 Query: 293 QLK 295 LK Sbjct: 198 SLK 200 Score = 86.3 bits (212), Expect = 3e-17 Identities = 56/186 (30%), Positives = 91/186 (48%), Gaps = 21/186 (11%) Query: 14 TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73 +V F+ G AAC+A L P+D + R QGE + Y + + TM R+E Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPK---------VYNTLRHAVGTMYRSE 169 Query: 74 GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY-----TKGSEHASIGSRLLAGSTTGA 128 GP+ Y GL L +A ++ Y S+K Y +G ++ ++ LL GS G Sbjct: 170 GPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGV 228 Query: 129 LAVAVAQPTDVVKVRFQ------AQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPN 182 ++ + P D+ K R Q A+A G RRY+ ++ K + ++EG G +KG SP+ Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288 Query: 183 VARNAI 188 + + A+ Sbjct: 289 LLKAAL 294 >gi|186928858 solute carrier family 25, member 19 [Homo sapiens] Length = 320 Score = 92.0 bits (227), Expect = 6e-19 Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 32/293 (10%) Query: 23 AACIADLIT----FPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78 A ++ L+T P D K+R Q+Q E R+ SA+Y G++ +++ EGP + Sbjct: 21 AGSVSGLVTRALISPFDVIKIRFQLQHERLS--RSDPSAKYHGILQASRQILQEEGPTAF 78 Query: 79 YNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS--IGSRLLAGSTTGALAVAVAQP 136 + G V + + +V+ ++ + + +GS + + + G +A P Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138 Query: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196 DV++ RF AQ G + Y + +A T+ R EG + +KG +P + + Sbjct: 139 VDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195 Query: 197 YDLIKD-------ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTR-------Y 242 Y +K A K N +L C GAG + + P+D+ K R + Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLC----GSGAGVISKTLTYPLDLFKKRLQVGGFEH 251 Query: 243 MNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292 +A GQ Y CA +LQKEG F+KG PS L+ MF +YE Sbjct: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304 Score = 87.4 bits (215), Expect = 1e-17 Identities = 52/183 (28%), Positives = 93/183 (50%), Gaps = 10/183 (5%) Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ----ARAGGGRRYQSTVNAYKTIAREEGFRGLW 176 +AGS +G + A+ P DV+K+RFQ Q +R+ +Y + A + I +EEG W Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79 Query: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPV 235 KG P + + ++++++ + + + ++ + HF A T+ PV Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139 Query: 236 DVVKTRYMNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292 DV++TR+ +A G+ Y++ H TM + EGP+ FYKG P+ + + + + F Y Sbjct: 140 DVLRTRF--AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197 Query: 293 QLK 295 LK Sbjct: 198 SLK 200 Score = 86.3 bits (212), Expect = 3e-17 Identities = 56/186 (30%), Positives = 91/186 (48%), Gaps = 21/186 (11%) Query: 14 TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73 +V F+ G AAC+A L P+D + R QGE + Y + + TM R+E Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPK---------VYNTLRHAVGTMYRSE 169 Query: 74 GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY-----TKGSEHASIGSRLLAGSTTGA 128 GP+ Y GL L +A ++ Y S+K Y +G ++ ++ LL GS G Sbjct: 170 GPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGV 228 Query: 129 LAVAVAQPTDVVKVRFQ------AQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPN 182 ++ + P D+ K R Q A+A G RRY+ ++ K + ++EG G +KG SP+ Sbjct: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288 Query: 183 VARNAI 188 + + A+ Sbjct: 289 LLKAAL 294 >gi|21361103 solute carrier family 25, member 12 [Homo sapiens] Length = 678 Score = 90.5 bits (223), Expect = 2e-18 Identities = 76/284 (26%), Positives = 115/284 (40%), Gaps = 12/284 (4%) Query: 16 KFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGP 75 +F A + +P+D K R+Q Q +G Y+ ++R EG Sbjct: 329 RFTLGSVAGAVGATAVYPIDLVKTRMQNQ---RGSGSVVGELMYKNSFDCFKKVLRYEGF 385 Query: 76 RSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQ 135 LY GL+ L ++++ + D V+ +T+ + + +LAG G V Sbjct: 386 FGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTN 445 Query: 136 PTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195 P ++VK+R Q G R + + R+ G GL+KG R+ + Sbjct: 446 PLEIVKIRLQVAGEITTGPRVSAL-----NVLRDLGIFGLYKGAKACFLRDIPFSAIYFP 500 Query: 196 TYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSA-LGQ--YSS 252 Y K L N L A AG + +P DV+KTR +A GQ YS Sbjct: 501 VYAHCKLLLADENGHVGGLNLLAAGAM-AGVPAASLVTPADVIKTRLQVAARAGQTTYSG 559 Query: 253 AGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 C +L++EGP AF+KG R V VTYE L+R Sbjct: 560 VIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQR 603 Score = 86.7 bits (213), Expect = 2e-17 Identities = 62/193 (32%), Positives = 90/193 (46%), Gaps = 14/193 (7%) Query: 9 VPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILT 68 VP A V L G A + T PL+ K+RLQ+ GE R +A L Sbjct: 424 VPLPAEV--LAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSA-----------LN 470 Query: 69 MVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGA 128 ++R G LY G A R + F+++ +Y K + H + L AG+ G Sbjct: 471 VLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGV 530 Query: 129 LAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAI 188 A ++ P DV+K R Q ARA G Y ++ ++ I REEG WKGT+ V R++ Sbjct: 531 PAASLVTPADVIKTRLQVAARA-GQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSP 589 Query: 189 VNCAELVTYDLIK 201 LVTY+L++ Sbjct: 590 QFGVTLVTYELLQ 602 Score = 70.1 bits (170), Expect = 2e-12 Identities = 51/184 (27%), Positives = 82/184 (44%), Gaps = 7/184 (3%) Query: 119 RLLAGSTTGALAVAVAQPTDVVKVRFQAQARAG---GGRRYQSTVNAYKTIAREEGFRGL 175 R GS GA+ P D+VK R Q Q +G G Y+++ + +K + R EGF GL Sbjct: 329 RFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGL 388 Query: 176 WKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPV 235 ++G P + A +L D ++D + + LP + AG + +P+ Sbjct: 389 YRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVP-LPAEVLAGGCAGGSQVIFTNPL 447 Query: 236 DVVKTRYMNSALGQYSSAGHC-ALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294 ++VK R G+ ++ AL +L+ G YKG FLR ++ + F Y Sbjct: 448 EIVKIRLQ--VAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHC 505 Query: 295 KRAL 298 K L Sbjct: 506 KLLL 509 Score = 35.0 bits (79), Expect = 0.084 Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 10/95 (10%) Query: 15 VKFLGAGTAACI--ADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRT 72 + L AG A + A L+T P D K RLQ+ + Y GV+ ++R Sbjct: 519 LNLLAAGAMAGVPAASLVT-PADVIKTRLQVAARA-------GQTTYSGVIDCFRKILRE 570 Query: 73 EGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY 107 EGP + + G A + R V + Y+ +++++ Sbjct: 571 EGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWF 605 >gi|157388925 solute carrier family 25, member 38 [Homo sapiens] Length = 304 Score = 90.1 bits (222), Expect = 2e-18 Identities = 71/280 (25%), Positives = 129/280 (46%), Gaps = 16/280 (5%) Query: 17 FLGAGTAACIADLITFPLDTAKVRLQ-IQGESQGPVRATASAQYRGVMGTILTMVRTEGP 75 FL + + L+ PLD K RLQ +Q G R G++ +L +VRTE Sbjct: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRV-------GMLAVLLKVVRTESL 83 Query: 76 RSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQ 135 L+ G+ + R + + G S+KQ++ +G ++ S +L G + ++A Sbjct: 84 LGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVML-GVGSRSVAGVCMS 142 Query: 136 PTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195 P V+K R+++ G Y+S A ++I EG RGL+ G + + R+A + L+ Sbjct: 143 PITVIKTRYES-----GKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLM 197 Query: 196 TYDLIKDALLKANLMTDDLP-CHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254 Y+ K+ + + +P +F+ AG +++ P DV+KT L ++ G Sbjct: 198 FYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPL-KFQWIG 256 Query: 255 HCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294 + + G R F++G +P LR + + YE++ Sbjct: 257 QAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEM 296 Score = 64.7 bits (156), Expect = 1e-10 Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 7/177 (3%) Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180 L GS +G + + QP D++K R Q + G R + + R E GLWKG S Sbjct: 32 LCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMS 91 Query: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMT--DDLPCHFTSAFGAGFCTTVIASPVDVV 238 P++ R T +K L+ + T + + S AG C SP+ V+ Sbjct: 92 PSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVC----MSPITVI 147 Query: 239 KTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295 KTRY + G Y S ++ EG R + G + LR ++ + + Y Q K Sbjct: 148 KTRYESGKYG-YESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTK 203 >gi|13775208 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [Homo sapiens] Length = 315 Score = 90.1 bits (222), Expect = 2e-18 Identities = 69/287 (24%), Positives = 127/287 (44%), Gaps = 15/287 (5%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77 L G AA ++ P++ K+ LQ+Q S+ + + A+Y+G++ ++ + R +G S Sbjct: 25 LAGGVAAAVSKTAVAPIERVKLLLQVQASSK---QISPEARYKGMVDCLVRIPREQGFFS 81 Query: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLLAGSTTGALAVA 132 + G +A + R ++ D KQ + G + L +G GA ++ Sbjct: 82 FWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLC 141 Query: 133 VAQPTDVVKVRFQAQARAGGG-RRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNC 191 V P D + R G R+++ + IA+ +G GL++G +V + Sbjct: 142 VVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYRA 201 Query: 192 AELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYM---NSALG 248 + YD +K L K T L F + C+ +++ P D V+ R M A Sbjct: 202 SYFGAYDTVKGLLPKPK-KTPFLVSFFIAQV-VTTCSGILSYPFDTVRRRMMMQSGEAKR 259 Query: 249 QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295 QY C + + Q EG +F++G + LR G+ ++ V Y+++K Sbjct: 260 QYKGTLDCFVKIYQHEGISSFFRGAFSNVLR-GTGGALVLVLYDKIK 305 Score = 63.5 bits (153), Expect = 2e-10 Identities = 48/182 (26%), Positives = 84/182 (46%), Gaps = 8/182 (4%) Query: 21 GTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYN 80 G A + + +PLD A+ RL + +GP Q++G+ I+ + +++G LY Sbjct: 133 GAAGATSLCVVYPLDFARTRLGVD-IGKGP----EERQFKGLGDCIMKIAKSDGIAGLYQ 187 Query: 81 GLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVV 140 G +Q + + + G YD+VK K + + S +A T + ++ P D V Sbjct: 188 GFGVSVQGIIVYRASYFGAYDTVKGLLPKPKKTPFLVSFFIAQVVTTCSGI-LSYPFDTV 246 Query: 141 KVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLI 200 + R Q+ R+Y+ T++ + I + EG ++G NV R LV YD I Sbjct: 247 RRRMMMQS-GEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGT-GGALVLVLYDKI 304 Query: 201 KD 202 K+ Sbjct: 305 KE 306 Score = 59.3 bits (142), Expect = 4e-09 Identities = 49/198 (24%), Positives = 77/198 (38%), Gaps = 14/198 (7%) Query: 114 ASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARA---GGGRRYQSTVNAYKTIAREE 170 +S G LLAG A++ P + VK+ Q QA + RY+ V+ I RE+ Sbjct: 18 SSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQ 77 Query: 171 GFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALL----KANLMTDDLPCHFTSAFGAGF 226 GF W+G NV R D K + K + S AG Sbjct: 78 GFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGA 137 Query: 227 CTTVIASPVDVVKTRYMNSALG------QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRL 280 + + P+D +TR + +G Q+ G C + + + +G Y+GF S + Sbjct: 138 TSLCVVYPLDFARTR-LGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGI 196 Query: 281 GSWNVVMFVTYEQLKRAL 298 + F Y+ +K L Sbjct: 197 IVYRASYFGAYDTVKGLL 214 Score = 43.5 bits (101), Expect = 2e-04 Identities = 28/105 (26%), Positives = 48/105 (45%), Gaps = 13/105 (12%) Query: 15 VKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEG 74 V F A + ++++P DT + R+ +Q A QY+G + + + + EG Sbjct: 224 VSFFIAQVVTTCSGILSYPFDTVRRRMMMQS-------GEAKRQYKGTLDCFVKIYQHEG 276 Query: 75 PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSR 119 S + G + + R A V + LYD +K+F+ H IG R Sbjct: 277 ISSFFRGAFSNVLRGTGGALVLV-LYDKIKEFF-----HIDIGGR 315 >gi|55749577 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 [Homo sapiens] Length = 298 Score = 88.6 bits (218), Expect = 6e-18 Identities = 73/295 (24%), Positives = 126/295 (42%), Gaps = 25/295 (8%) Query: 17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPR 76 FL G AA ++ P++ K+ LQ+Q S+ + +A QY+G++ ++ + + +G Sbjct: 12 FLAGGVAAAVSKTAVAPIERVKLLLQVQHASK---QISAEKQYKGIIDCVVRIPKEQGFL 68 Query: 77 SLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS-----IGSRLLAGSTTGALAV 131 S + G +A + R ++ D KQ + G + L +G GA ++ Sbjct: 69 SFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSL 128 Query: 132 AVAQPTDVVKVRFQAQARAGGGRR-YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVN 190 P D + R A G +R + + I + +G RGL++G + +V I Sbjct: 129 CFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYR 188 Query: 191 CAELVTYDLIKDALLKANLMTDDLPCH-FTSAFGAGFCTTV---IASPVDVVKTRYM--- 243 A YD K ++ D H F S A T V ++ P D V+ R M Sbjct: 189 AAYFGVYDTAK------GMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQS 242 Query: 244 --NSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296 A Y+ C + + EG +AF+KG + LR G + V Y+++K+ Sbjct: 243 GRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLR-GMGGAFVLVLYDEIKK 296 Score = 53.5 bits (127), Expect = 2e-07 Identities = 43/190 (22%), Positives = 71/190 (37%), Gaps = 12/190 (6%) Query: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ---ARAGGGRRYQSTVNAYKTIAREEGFRGLWK 177 LAG A++ P + VK+ Q Q + ++Y+ ++ I +E+GF W+ Sbjct: 13 LAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWR 72 Query: 178 GTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFT----SAFGAGFCTTVIAS 233 G NV R D K L +F S AG + Sbjct: 73 GNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVY 132 Query: 234 PVDVVKTRYM-----NSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMF 288 P+D +TR +A ++ G C + + + +G R Y+GF S + + F Sbjct: 133 PLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYF 192 Query: 289 VTYEQLKRAL 298 Y+ K L Sbjct: 193 GVYDTAKGML 202 Score = 42.4 bits (98), Expect = 5e-04 Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 6/92 (6%) Query: 15 VKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEG 74 V ++ A + +A L+++P DT + R+ +Q +G A Y G + + + EG Sbjct: 212 VSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKG-----ADIMYTGTVDCWRKIAKDEG 266 Query: 75 PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQF 106 ++ + G + + R M A V + LYD +K++ Sbjct: 267 AKAFFKGAWSNVLRGMGGAFVLV-LYDEIKKY 297 >gi|239755176 PREDICTED: similar to solute carrier family 25, member 25 isoform 2 [Homo sapiens] Length = 469 Score = 88.6 bits (218), Expect = 6e-18 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77 + G A ++ T PLD KV +Q+ + G++G M+R G RS Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 241 Query: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137 L+ G + + ++++ Y+ +K+ E I RL+AGS GA+A + P Sbjct: 242 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 301 Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197 +V+K R A + G +Y ++ + I EG +KG PN+ +L Y Sbjct: 302 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 357 Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254 + +K+A L+ + P F A G + C + + P+ +V+TR Q S G Sbjct: 358 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 413 Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298 +TM L+ EG Y+G P+F+++ + +V YE LK L Sbjct: 414 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 464 Score = 79.7 bits (195), Expect = 3e-15 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%) Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179 L+AG GA++ P D +KV Q A V + + RE G R LW+G Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 246 Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239 NV + A + + + Y+ IK L+ ++ T + + AG P++V+K Sbjct: 247 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 305 Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297 TR GQYS CA +L +EG AFYKG++P+ L + + + YE LK A Sbjct: 306 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 363 >gi|239755174 PREDICTED: similar to solute carrier family 25, member 25 isoform 1 [Homo sapiens] Length = 503 Score = 88.6 bits (218), Expect = 6e-18 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77 + G A ++ T PLD KV +Q+ + G++G M+R G RS Sbjct: 225 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 275 Query: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137 L+ G + + ++++ Y+ +K+ E I RL+AGS GA+A + P Sbjct: 276 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 335 Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197 +V+K R A + G +Y ++ + I EG +KG PN+ +L Y Sbjct: 336 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 391 Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254 + +K+A L+ + P F A G + C + + P+ +V+TR Q S G Sbjct: 392 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 447 Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298 +TM L+ EG Y+G P+F+++ + +V YE LK L Sbjct: 448 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 498 Score = 79.7 bits (195), Expect = 3e-15 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%) Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179 L+AG GA++ P D +KV Q A V + + RE G R LW+G Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 280 Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239 NV + A + + + Y+ IK L+ ++ T + + AG P++V+K Sbjct: 281 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 339 Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297 TR GQYS CA +L +EG AFYKG++P+ L + + + YE LK A Sbjct: 340 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 397 >gi|56699407 solute carrier family 25, member 25 isoform c [Homo sapiens] Length = 489 Score = 88.6 bits (218), Expect = 6e-18 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77 + G A ++ T PLD KV +Q+ + G++G M+R G RS Sbjct: 211 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 261 Query: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137 L+ G + + ++++ Y+ +K+ E I RL+AGS GA+A + P Sbjct: 262 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 321 Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197 +V+K R A + G +Y ++ + I EG +KG PN+ +L Y Sbjct: 322 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 377 Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254 + +K+A L+ + P F A G + C + + P+ +V+TR Q S G Sbjct: 378 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 433 Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298 +TM L+ EG Y+G P+F+++ + +V YE LK L Sbjct: 434 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 484 Score = 79.7 bits (195), Expect = 3e-15 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%) Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179 L+AG GA++ P D +KV Q A V + + RE G R LW+G Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 266 Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239 NV + A + + + Y+ IK L+ ++ T + + AG P++V+K Sbjct: 267 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 325 Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297 TR GQYS CA +L +EG AFYKG++P+ L + + + YE LK A Sbjct: 326 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 383 >gi|56699401 solute carrier family 25, member 25 isoform a [Homo sapiens] Length = 469 Score = 88.6 bits (218), Expect = 6e-18 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77 + G A ++ T PLD KV +Q+ + G++G M+R G RS Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 241 Query: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137 L+ G + + ++++ Y+ +K+ E I RL+AGS GA+A + P Sbjct: 242 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 301 Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197 +V+K R A + G +Y ++ + I EG +KG PN+ +L Y Sbjct: 302 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 357 Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254 + +K+A L+ + P F A G + C + + P+ +V+TR Q S G Sbjct: 358 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 413 Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298 +TM L+ EG Y+G P+F+++ + +V YE LK L Sbjct: 414 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 464 Score = 79.7 bits (195), Expect = 3e-15 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%) Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179 L+AG GA++ P D +KV Q A V + + RE G R LW+G Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 246 Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239 NV + A + + + Y+ IK L+ ++ T + + AG P++V+K Sbjct: 247 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 305 Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297 TR GQYS CA +L +EG AFYKG++P+ L + + + YE LK A Sbjct: 306 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 363 >gi|56699405 solute carrier family 25, member 25 isoform d [Homo sapiens] Length = 366 Score = 88.6 bits (218), Expect = 6e-18 Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 27/291 (9%) Query: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77 + G A ++ T PLD KV +Q+ + G++G M+R G RS Sbjct: 88 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM---------GIVGGFTQMIREGGARS 138 Query: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPT 137 L+ G + + ++++ Y+ +K+ E I RL+AGS GA+A + P Sbjct: 139 LWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPM 198 Query: 138 DVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197 +V+K R A + G +Y ++ + I EG +KG PN+ +L Y Sbjct: 199 EVLKTR-MALRKTG---QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVY 254 Query: 198 DLIKDALLKANLMTDDLPCHFT-SAFG--AGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254 + +K+A L+ + P F A G + C + + P+ +V+TR Q S G Sbjct: 255 ETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ----AQASIEG 310 Query: 255 HCALTM-------LQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298 +TM L+ EG Y+G P+F+++ + +V YE LK L Sbjct: 311 APEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 361 Score = 79.7 bits (195), Expect = 3e-15 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 4/178 (2%) Query: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGT 179 L+AG GA++ P D +KV Q A V + + RE G R LW+G Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN---MGIVGGFTQMIREGGARSLWRGN 143 Query: 180 SPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVK 239 NV + A + + + Y+ IK L+ ++ T + + AG P++V+K Sbjct: 144 GINVLKIAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 202 Query: 240 TRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297 TR GQYS CA +L +EG AFYKG++P+ L + + + YE LK A Sbjct: 203 TRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNA 260 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.133 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,280,541 Number of Sequences: 37866 Number of extensions: 385775 Number of successful extensions: 1360 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 65 Number of HSP's successfully gapped in prelim test: 12 Number of HSP's that attempted gapping in prelim test: 726 Number of HSP's gapped (non-prelim): 205 length of query: 309 length of database: 18,247,518 effective HSP length: 102 effective length of query: 207 effective length of database: 14,385,186 effective search space: 2977733502 effective search space used: 2977733502 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.