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Search of human proteins with 46488944
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46488944 zeta-chain associated protein kinase 70kDa isoform
2 [Homo sapiens]
(312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 643 0.0
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 643 0.0
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 383 e-106
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 383 e-106
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 216 2e-56
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 216 2e-56
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 208 6e-54
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 208 6e-54
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 206 2e-53
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 206 2e-53
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 205 4e-53
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 205 4e-53
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 204 6e-53
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 202 2e-52
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 202 2e-52
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 202 3e-52
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 201 7e-52
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 201 7e-52
gi|4758282 ephrin receptor EphA7 [Homo sapiens] 201 7e-52
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 200 2e-51
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 199 3e-51
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 199 3e-51
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 199 3e-51
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 199 3e-51
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 199 3e-51
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 197 8e-51
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 197 8e-51
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 197 1e-50
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 197 1e-50
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 197 1e-50
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 643 bits (1659), Expect = 0.0
Identities = 312/312 (100%), Positives = 312/312 (100%)
Query: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60
MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA
Sbjct: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60
Query: 61 IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV 120
IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV
Sbjct: 61 IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV 120
Query: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG
Sbjct: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
Query: 181 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 240
ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE
Sbjct: 181 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 240
Query: 241 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 300
VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP
Sbjct: 241 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 300
Query: 301 PGSTQKAEAACA 312
PGSTQKAEAACA
Sbjct: 301 PGSTQKAEAACA 312
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 643 bits (1659), Expect = 0.0
Identities = 312/312 (100%), Positives = 312/312 (100%)
Query: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60
MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA
Sbjct: 308 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 367
Query: 61 IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV 120
IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV
Sbjct: 368 IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV 427
Query: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG
Sbjct: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487
Query: 181 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 240
ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE
Sbjct: 488 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 547
Query: 241 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 300
VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP
Sbjct: 548 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607
Query: 301 PGSTQKAEAACA 312
PGSTQKAEAACA
Sbjct: 608 PGSTQKAEAACA 619
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 383 bits (983), Expect = e-106
Identities = 183/296 (61%), Positives = 232/296 (78%), Gaps = 2/296 (0%)
Query: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60
+PMDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G Y+M+K VA
Sbjct: 318 LPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVA 377
Query: 61 IKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFL 119
+K+LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L
Sbjct: 378 VKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL 437
Query: 120 VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL 179
R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL
Sbjct: 438 QQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 496
Query: 180 GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP 239
AD++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG
Sbjct: 497 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 556
Query: 240 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 295
EV A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R YY + +
Sbjct: 557 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 612
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 383 bits (983), Expect = e-106
Identities = 183/296 (61%), Positives = 232/296 (78%), Gaps = 2/296 (0%)
Query: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60
+PMDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G Y+M+K VA
Sbjct: 341 LPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVA 400
Query: 61 IKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFL 119
+K+LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L
Sbjct: 401 VKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL 460
Query: 120 VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL 179
R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL
Sbjct: 461 QQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519
Query: 180 GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP 239
AD++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG
Sbjct: 520 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 579
Query: 240 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 295
EV A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R YY + +
Sbjct: 580 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 216 bits (550), Expect = 2e-56
Identities = 108/251 (43%), Positives = 158/251 (62%), Gaps = 3/251 (1%)
Query: 37 LGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 95
+G G FG V QG+Y + + VAIK K T + E+ ++EA M Q D+P+IV+LI
Sbjct: 450 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 509
Query: 96 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 155
GV + ++ME+ G L FL ++ + ++++ +Q+S + YLE K FVHRD+
Sbjct: 510 GVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDI 569
Query: 156 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 215
AARNVL+ + K+ DFGLS+ + +DS Y S GK P+KW APE INFR+F+S SDV
Sbjct: 570 AARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDV 627
Query: 216 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 275
W +GV MWE L +G KP++ +K +V+ IE G+R+ PP CPP LY+LM+ CW Y
Sbjct: 628 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR 687
Query: 276 RPDFLTVEQRM 286
RP F ++ ++
Sbjct: 688 RPRFTELKAQL 698
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 216 bits (550), Expect = 2e-56
Identities = 108/251 (43%), Positives = 158/251 (62%), Gaps = 3/251 (1%)
Query: 37 LGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 95
+G G FG V QG+Y + + VAIK K T + E+ ++EA M Q D+P+IV+LI
Sbjct: 428 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 487
Query: 96 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 155
GV + ++ME+ G L FL ++ + ++++ +Q+S + YLE K FVHRD+
Sbjct: 488 GVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDI 547
Query: 156 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 215
AARNVL+ + K+ DFGLS+ + +DS Y S GK P+KW APE INFR+F+S SDV
Sbjct: 548 AARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDV 605
Query: 216 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 275
W +GV MWE L +G KP++ +K +V+ IE G+R+ PP CPP LY+LM+ CW Y
Sbjct: 606 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR 665
Query: 276 RPDFLTVEQRM 286
RP F ++ ++
Sbjct: 666 RPRFTELKAQL 676
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 208 bits (529), Expect = 6e-54
Identities = 122/313 (38%), Positives = 177/313 (56%), Gaps = 16/313 (5%)
Query: 3 MDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRM-RKKQIDVAI 61
+D YE P E + L N+ I D +G G FG V G ++ KK+I VAI
Sbjct: 597 VDPHTYEDPTQAVHEFAKE---LDATNISI-DKVVGAGEFGEVCSGRLKLPSKKEISVAI 652
Query: 62 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 120
K LK G + + + EA IM Q D+P I+RL GV +++ +M+V E G L FL
Sbjct: 653 KTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR 712
Query: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
+ V + +L ++ GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L
Sbjct: 713 KHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLE 772
Query: 181 AD-DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP 239
D ++ YT R GK P++W +PE I +RKF+S SDVWSYG+ +WE +SYG++PY +M
Sbjct: 773 DDPEAAYTTRG-GKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQ 831
Query: 240 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 299
+V+ +++G R+ P +CP LY LM DCW +RP F + S+ K+
Sbjct: 832 DVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQI--------VSILDKLIR 883
Query: 300 PPGSTQKAEAACA 312
PGS + +A A
Sbjct: 884 NPGSLKIITSAAA 896
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 208 bits (529), Expect = 6e-54
Identities = 118/284 (41%), Positives = 165/284 (58%), Gaps = 10/284 (3%)
Query: 7 VYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAI 61
+Y P Y DP E + F K ++ IE +G G FG V +G ++ K++I VAI
Sbjct: 593 IYIDPFTYEDPNEAVRE--FAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAI 650
Query: 62 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 120
K LK G + + + EA IM Q D+P I+RL GV ++ +M++ E G L FL
Sbjct: 651 KTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLR 710
Query: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
+ V + +L ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L
Sbjct: 711 QNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQ 770
Query: 181 AD--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 238
D D YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +S+G++PY M
Sbjct: 771 DDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSN 830
Query: 239 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 282
+V+ IEQ R+ P +CP L+ LM DCW RP F +
Sbjct: 831 QDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI 874
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 206 bits (525), Expect = 2e-53
Identities = 115/273 (42%), Positives = 161/273 (58%), Gaps = 8/273 (2%)
Query: 12 YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAIKVLKQGT 68
Y DP + + F K IE +G G FG V G ++ K+++ VAIK LK G
Sbjct: 634 YEDPNQAVHE--FAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY 691
Query: 69 EKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIP 127
+ + + EA IM Q D+P I+ L GV +++ +M+V E G L FL +
Sbjct: 692 TEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFT 751
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD-DSYY 186
V + +L +S GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L D ++ Y
Sbjct: 752 VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 811
Query: 187 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 246
T R GK P++W APE I FRKF+S SDVWSYG+ MWE +SYG++PY +M +V+ +E
Sbjct: 812 TTRG-GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE 870
Query: 247 QGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
+G R+ P +CP LY LM DCW + RP F
Sbjct: 871 EGYRLPSPMDCPAALYQLMLDCWQKERNSRPKF 903
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 206 bits (525), Expect = 2e-53
Identities = 115/273 (42%), Positives = 161/273 (58%), Gaps = 8/273 (2%)
Query: 12 YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAIKVLKQGT 68
Y DP + + F K IE +G G FG V G ++ K+++ VAIK LK G
Sbjct: 656 YEDPNQAVHE--FAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY 713
Query: 69 EKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIP 127
+ + + EA IM Q D+P I+ L GV +++ +M+V E G L FL +
Sbjct: 714 TEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFT 773
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD-DSYY 186
V + +L +S GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L D ++ Y
Sbjct: 774 VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 833
Query: 187 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 246
T R GK P++W APE I FRKF+S SDVWSYG+ MWE +SYG++PY +M +V+ +E
Sbjct: 834 TTRG-GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE 892
Query: 247 QGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
+G R+ P +CP LY LM DCW + RP F
Sbjct: 893 EGYRLPSPMDCPAALYQLMLDCWQKERNSRPKF 925
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 205 bits (522), Expect = 4e-53
Identities = 116/281 (41%), Positives = 162/281 (57%), Gaps = 10/281 (3%)
Query: 7 VYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAI 61
+Y P Y DP E + F K ++ IE +G G FG V G ++ K++I VAI
Sbjct: 595 IYIDPFTYEDPNEAVRE--FAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAI 652
Query: 62 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 120
K LK G + + + EA IM Q D+P ++ L GV ++ +M++ E G L FL
Sbjct: 653 KTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR 712
Query: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
+ V + +L ++ GMKYL + N+VHRDLAARN+L+ + K+SDFGLS+ L
Sbjct: 713 QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLE 772
Query: 181 AD--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 238
D D YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M
Sbjct: 773 DDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN 832
Query: 239 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
+V+ IEQ R+ P +CP L+ LM DCW RP F
Sbjct: 833 QDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKF 873
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
sapiens]
Length = 987
Score = 205 bits (522), Expect = 4e-53
Identities = 116/281 (41%), Positives = 162/281 (57%), Gaps = 10/281 (3%)
Query: 7 VYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAI 61
+Y P Y DP E + F K ++ IE +G G FG V G ++ K++I VAI
Sbjct: 596 IYIDPFTYEDPNEAVRE--FAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAI 653
Query: 62 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 120
K LK G + + + EA IM Q D+P ++ L GV ++ +M++ E G L FL
Sbjct: 654 KTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR 713
Query: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
+ V + +L ++ GMKYL + N+VHRDLAARN+L+ + K+SDFGLS+ L
Sbjct: 714 QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLE 773
Query: 181 AD--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 238
D D YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M
Sbjct: 774 DDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN 833
Query: 239 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
+V+ IEQ R+ P +CP L+ LM DCW RP F
Sbjct: 834 QDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKF 874
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 204 bits (520), Expect = 6e-53
Identities = 111/284 (39%), Positives = 158/284 (55%), Gaps = 3/284 (1%)
Query: 2 PMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR--KKQIDV 59
P+ T V Y DP + K + + +G G FG V +G+ + KK++ V
Sbjct: 584 PLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPV 643
Query: 60 AIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKF 118
AIK LK G + + + EA IM Q + I+RL GV + +M++ E G L KF
Sbjct: 644 AIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKF 703
Query: 119 LVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA 178
L K E V + +L ++ GMKYL N+VHRDLAARN+L+ + K+SDFGLS+
Sbjct: 704 LREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRV 763
Query: 179 LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 238
L D S GK P++W APE I++RKF+S SDVWS+G+ MWE ++YG++PY ++
Sbjct: 764 LEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN 823
Query: 239 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 282
EVM I G R+ P +CP +Y LM CW + RP F +
Sbjct: 824 HEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADI 867
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 202 bits (515), Expect = 2e-52
Identities = 118/283 (41%), Positives = 162/283 (57%), Gaps = 10/283 (3%)
Query: 5 TSVYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDV 59
T VY P Y DP E + F K ++ IE +G G FG V +G + KK+ V
Sbjct: 587 TKVYIDPFTYEDPNEAVRE--FAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCV 644
Query: 60 AIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKF 118
AIK LK G + E + EA IM Q ++P I+RL GV + +M++ E G L F
Sbjct: 645 AIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSF 704
Query: 119 LVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA 178
L + V + +L ++ GM+YL E ++VHRDLAARN+L+ + K+SDFGLS+
Sbjct: 705 LRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRF 764
Query: 179 L--GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 236
L + D YT+ GK P++W APE I FRKF+S SD WSYG+ MWE +S+G++PY M
Sbjct: 765 LEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDM 824
Query: 237 KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
+V+ IEQ R+ PP+CP L+ LM DCW RP F
Sbjct: 825 SNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRF 867
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 202 bits (515), Expect = 2e-52
Identities = 103/269 (38%), Positives = 161/269 (59%), Gaps = 7/269 (2%)
Query: 19 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 78
KDKK L +++++ ++ LG GNFG V +G K + VA+K K+ + + ++
Sbjct: 552 KDKKWILSHEDVILGEL-LGKGNFGEVYKGTL---KDKTSVAVKTCKEDLPQELKIKFLQ 607
Query: 79 EAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 137
EA+I+ Q D+P IV+LIGVC Q + + ++ME+ GG FL K++E+ + + +
Sbjct: 608 EAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLD 667
Query: 138 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 197
+ GM YLE KN +HRDLAARN L+ + KISDFG+S+ D Y++ + P+K
Sbjct: 668 AAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQ--EDGGVYSSSGLKQIPIK 725
Query: 198 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 257
W APE +N+ ++SS SDVWS+G+ +WE S G PY M + +E+G RM P C
Sbjct: 726 WTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHC 785
Query: 258 PPELYALMSDCWIYKWEDRPDFLTVEQRM 286
P ++ +M CW YK E+RP F +++ +
Sbjct: 786 PEDISKIMMKCWDYKPENRPKFSELQKEL 814
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 202 bits (514), Expect = 3e-52
Identities = 116/281 (41%), Positives = 163/281 (58%), Gaps = 10/281 (3%)
Query: 7 VYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAI 61
VY P Y DP E + F K ++ IE +G G FG V +G + ++++ VAI
Sbjct: 607 VYIDPFTYEDPNEAVRE--FAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAI 664
Query: 62 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 120
K LK G + + + EA IM Q D+P I+RL GV ++ +M++ E L FL
Sbjct: 665 KTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLR 724
Query: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
+ V + +L ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L
Sbjct: 725 LNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLE 784
Query: 181 AD--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 238
D D YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M
Sbjct: 785 DDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN 844
Query: 239 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
+V+ +EQ R+ P +CP L+ LM DCW+ RP F
Sbjct: 845 QDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKF 885
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 201 bits (511), Expect = 7e-52
Identities = 102/245 (41%), Positives = 156/245 (63%), Gaps = 3/245 (1%)
Query: 37 LGCGNFGSVRQGVYRMRKK--QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 94
LG G FG+V +G++ + +I VAIK+L + T E M EA IM +D+P++VRL
Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 783
Query: 95 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 154
+GVC + + LV ++ G L +++ ++ I + Q++ GM YLEE+ VHRD
Sbjct: 784 LGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRD 843
Query: 155 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 214
LAARNVL+ + ++ KI+DFGL++ L D+ Y A GK P+KW A ECI++RKF+ +SD
Sbjct: 844 LAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGGKMPIKWMALECIHYRKFTHQSD 902
Query: 215 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 274
VWSYGVT+WE +++G KPY + E+ +E+G+R+ PP C ++Y +M CW+ +
Sbjct: 903 VWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDAD 962
Query: 275 DRPDF 279
RP F
Sbjct: 963 SRPKF 967
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 201 bits (511), Expect = 7e-52
Identities = 102/245 (41%), Positives = 156/245 (63%), Gaps = 3/245 (1%)
Query: 37 LGCGNFGSVRQGVYRMRKK--QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 94
LG G FG+V +G++ + +I VAIK+L + T E M EA IM +D+P++VRL
Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 783
Query: 95 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 154
+GVC + + LV ++ G L +++ ++ I + Q++ GM YLEE+ VHRD
Sbjct: 784 LGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRD 843
Query: 155 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 214
LAARNVL+ + ++ KI+DFGL++ L D+ Y A GK P+KW A ECI++RKF+ +SD
Sbjct: 844 LAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGGKMPIKWMALECIHYRKFTHQSD 902
Query: 215 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 274
VWSYGVT+WE +++G KPY + E+ +E+G+R+ PP C ++Y +M CW+ +
Sbjct: 903 VWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDAD 962
Query: 275 DRPDF 279
RP F
Sbjct: 963 SRPKF 967
>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
Length = 998
Score = 201 bits (511), Expect = 7e-52
Identities = 110/276 (39%), Positives = 158/276 (57%), Gaps = 8/276 (2%)
Query: 12 YSDPEELKDKKL----FLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAIKVL 64
Y DPE +D F K + IE +G G FG V G ++ K+ + VAIK L
Sbjct: 608 YIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTL 667
Query: 65 KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR 123
K G + + + EA IM Q D+P +V L GV + + +M+V+E G L FL
Sbjct: 668 KVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHD 727
Query: 124 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD 183
+ V + +L ++ GM+YL + +VHRDLAARN+L+ + K+SDFGLS+ + D
Sbjct: 728 GQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDP 787
Query: 184 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 243
+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M +V+
Sbjct: 788 EAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIK 847
Query: 244 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
IE+G R+ P +CP L+ LM DCW + +RP F
Sbjct: 848 AIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKF 883
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 200 bits (508), Expect = 2e-51
Identities = 112/277 (40%), Positives = 161/277 (58%), Gaps = 6/277 (2%)
Query: 8 YESPYSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAIKVL 64
Y P++ + + + F K + IE +G G FG V G ++ K++I VAIK L
Sbjct: 596 YVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTL 655
Query: 65 KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR 123
K G + + EA IM Q D+P I+ L GV + + +M++ E G L FL
Sbjct: 656 KAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKND 715
Query: 124 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD- 182
V + +L + GMKYL + ++VHRDLAARN+L+ + K+SDFG+S+ L D
Sbjct: 716 GRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDP 775
Query: 183 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM 242
++ YT R GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M +V+
Sbjct: 776 EAAYTTRG-GKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVI 834
Query: 243 AFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
IE+G R+ P +CP L+ LM DCW + DRP F
Sbjct: 835 KAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKF 871
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 199 bits (506), Expect = 3e-51
Identities = 107/284 (37%), Positives = 161/284 (56%), Gaps = 16/284 (5%)
Query: 10 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 69
SP D E++ + +K +LG G +G V GV++ K + VA+K LK+ T
Sbjct: 260 SPIHDKWEMERTDITMKH--------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT- 308
Query: 70 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIP 127
+ EE ++EA +M ++ +P +V+L+GVC E ++ M G L REE+
Sbjct: 309 -MEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 367
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 187
+ + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YT
Sbjct: 368 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YT 425
Query: 188 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 247
A + K+P+KW APE + + FS +SDVW++GV +WE +YG PY + +V +E+
Sbjct: 426 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 485
Query: 248 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 291
G RME P CPP++Y LM CW + DRP F Q ++
Sbjct: 486 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 529
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 199 bits (506), Expect = 3e-51
Identities = 107/284 (37%), Positives = 161/284 (56%), Gaps = 16/284 (5%)
Query: 10 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 69
SP D E++ + +K +LG G +G V GV++ K + VA+K LK+ T
Sbjct: 275 SPIHDKWEMERTDITMKH--------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT- 323
Query: 70 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIP 127
+ EE ++EA +M ++ +P +V+L+GVC E ++ M G L REE+
Sbjct: 324 -MEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 382
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 187
+ + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YT
Sbjct: 383 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YT 440
Query: 188 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 247
A + K+P+KW APE + + FS +SDVW++GV +WE +YG PY + +V +E+
Sbjct: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500
Query: 248 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 291
G RME P CPP++Y LM CW + DRP F Q ++
Sbjct: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 544
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 199 bits (506), Expect = 3e-51
Identities = 107/284 (37%), Positives = 161/284 (56%), Gaps = 16/284 (5%)
Query: 10 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 69
SP D E++ + +K +LG G +G V GV++ K + VA+K LK+ T
Sbjct: 254 SPIHDKWEMERTDITMKH--------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT- 302
Query: 70 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIP 127
+ EE ++EA +M ++ +P +V+L+GVC E ++ M G L REE+
Sbjct: 303 -MEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 361
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 187
+ + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YT
Sbjct: 362 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YT 419
Query: 188 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 247
A + K+P+KW APE + + FS +SDVW++GV +WE +YG PY + +V +E+
Sbjct: 420 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 479
Query: 248 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 291
G RME P CPP++Y LM CW + DRP F Q ++
Sbjct: 480 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 523
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 199 bits (506), Expect = 3e-51
Identities = 107/284 (37%), Positives = 161/284 (56%), Gaps = 16/284 (5%)
Query: 10 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 69
SP D E++ + +K +LG G +G V GV++ K + VA+K LK+ T
Sbjct: 260 SPIHDKWEMERTDITMKH--------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT- 308
Query: 70 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIP 127
+ EE ++EA +M ++ +P +V+L+GVC E ++ M G L REE+
Sbjct: 309 -MEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 367
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 187
+ + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YT
Sbjct: 368 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YT 425
Query: 188 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 247
A + K+P+KW APE + + FS +SDVW++GV +WE +YG PY + +V +E+
Sbjct: 426 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 485
Query: 248 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 291
G RME P CPP++Y LM CW + DRP F Q ++
Sbjct: 486 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 529
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 199 bits (506), Expect = 3e-51
Identities = 107/284 (37%), Positives = 161/284 (56%), Gaps = 16/284 (5%)
Query: 10 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 69
SP D E++ + +K +LG G +G V GV++ K + VA+K LK+ T
Sbjct: 239 SPIHDKWEMERTDITMKH--------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT- 287
Query: 70 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIP 127
+ EE ++EA +M ++ +P +V+L+GVC E ++ M G L REE+
Sbjct: 288 -MEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 346
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 187
+ + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YT
Sbjct: 347 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YT 404
Query: 188 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 247
A + K+P+KW APE + + FS +SDVW++GV +WE +YG PY + +V +E+
Sbjct: 405 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 464
Query: 248 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 291
G RME P CPP++Y LM CW + DRP F Q ++
Sbjct: 465 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 508
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 197 bits (502), Expect = 8e-51
Identities = 108/293 (36%), Positives = 167/293 (56%), Gaps = 18/293 (6%)
Query: 10 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 69
SP D E++ + +K +LG G +G V +GV++ K + VA+K LK+ T
Sbjct: 229 SPNYDKWEMERTDITMKH--------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT- 277
Query: 70 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIP 127
+ EE ++EA +M ++ +P +V+L+GVC E ++ M G L R+E+
Sbjct: 278 -MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 336
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 187
+ + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YT
Sbjct: 337 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YT 394
Query: 188 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 247
A + K+P+KW APE + + KFS +SDVW++GV +WE +YG PY + +V +E+
Sbjct: 395 AHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK 454
Query: 248 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY--SLASKVE 298
RME P CP ++Y LM CW + DRP F + Q + S++ +VE
Sbjct: 455 DYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 507
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 197 bits (502), Expect = 8e-51
Identities = 108/293 (36%), Positives = 167/293 (56%), Gaps = 18/293 (6%)
Query: 10 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 69
SP D E++ + +K +LG G +G V +GV++ K + VA+K LK+ T
Sbjct: 248 SPNYDKWEMERTDITMKH--------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT- 296
Query: 70 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIP 127
+ EE ++EA +M ++ +P +V+L+GVC E ++ M G L R+E+
Sbjct: 297 -MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 355
Query: 128 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 187
+ + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YT
Sbjct: 356 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YT 413
Query: 188 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 247
A + K+P+KW APE + + KFS +SDVW++GV +WE +YG PY + +V +E+
Sbjct: 414 AHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK 473
Query: 248 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY--SLASKVE 298
RME P CP ++Y LM CW + DRP F + Q + S++ +VE
Sbjct: 474 DYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 526
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 197 bits (500), Expect = 1e-50
Identities = 104/256 (40%), Positives = 158/256 (61%), Gaps = 4/256 (1%)
Query: 25 LKRDNLLIADIELGCGNFGSVRQGVYRMRK-KQIDVAIKVLKQGTEKADTEEMMREAQIM 83
+ R+++++ I LG G FG V +GVY K ++I+VA+K K+ + E+ M EA IM
Sbjct: 420 IAREDVVLNRI-LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIM 478
Query: 84 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 143
LD+P+IV+LIG+ + E ++ME+ G L +L + + V + Q+ M
Sbjct: 479 KNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMA 538
Query: 144 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 203
YLE N VHRD+A RN+L+ + K+ DFGLS+ + D+ YY A S + P+KW +PE
Sbjct: 539 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKA-SVTRLPIKWMSPES 596
Query: 204 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 263
INFR+F++ SDVW + V MWE LS+G++P+ ++ +V+ +E+G R+ P CPP LY
Sbjct: 597 INFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT 656
Query: 264 LMSDCWIYKWEDRPDF 279
LM+ CW Y DRP F
Sbjct: 657 LMTRCWDYDPSDRPRF 672
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 197 bits (500), Expect = 1e-50
Identities = 104/256 (40%), Positives = 158/256 (61%), Gaps = 4/256 (1%)
Query: 25 LKRDNLLIADIELGCGNFGSVRQGVYRMRK-KQIDVAIKVLKQGTEKADTEEMMREAQIM 83
+ R+++++ I LG G FG V +GVY K ++I+VA+K K+ + E+ M EA IM
Sbjct: 420 IAREDVVLNRI-LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIM 478
Query: 84 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 143
LD+P+IV+LIG+ + E ++ME+ G L +L + + V + Q+ M
Sbjct: 479 KNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMA 538
Query: 144 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 203
YLE N VHRD+A RN+L+ + K+ DFGLS+ + D+ YY A S + P+KW +PE
Sbjct: 539 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKA-SVTRLPIKWMSPES 596
Query: 204 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 263
INFR+F++ SDVW + V MWE LS+G++P+ ++ +V+ +E+G R+ P CPP LY
Sbjct: 597 INFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT 656
Query: 264 LMSDCWIYKWEDRPDF 279
LM+ CW Y DRP F
Sbjct: 657 LMTRCWDYDPSDRPRF 672
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 197 bits (500), Expect = 1e-50
Identities = 104/256 (40%), Positives = 158/256 (61%), Gaps = 4/256 (1%)
Query: 25 LKRDNLLIADIELGCGNFGSVRQGVYRMRK-KQIDVAIKVLKQGTEKADTEEMMREAQIM 83
+ R+++++ I LG G FG V +GVY K ++I+VA+K K+ + E+ M EA IM
Sbjct: 420 IAREDVVLNRI-LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIM 478
Query: 84 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 143
LD+P+IV+LIG+ + E ++ME+ G L +L + + V + Q+ M
Sbjct: 479 KNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMA 538
Query: 144 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 203
YLE N VHRD+A RN+L+ + K+ DFGLS+ + D+ YY A S + P+KW +PE
Sbjct: 539 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKA-SVTRLPIKWMSPES 596
Query: 204 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 263
INFR+F++ SDVW + V MWE LS+G++P+ ++ +V+ +E+G R+ P CPP LY
Sbjct: 597 INFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT 656
Query: 264 LMSDCWIYKWEDRPDF 279
LM+ CW Y DRP F
Sbjct: 657 LMTRCWDYDPSDRPRF 672
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,398,595
Number of Sequences: 37866
Number of extensions: 522931
Number of successful extensions: 2936
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 628
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 1393
Number of HSP's gapped (non-prelim): 860
length of query: 312
length of database: 18,247,518
effective HSP length: 102
effective length of query: 210
effective length of database: 14,385,186
effective search space: 3020889060
effective search space used: 3020889060
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.