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Search of human proteins with 45439352
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens]
(225 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] 459 e-130
gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 105 4e-23
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 105 4e-23
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 90 2e-18
gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] 86 2e-17
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 65 4e-11
gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] 64 8e-11
gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] 49 3e-06
gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] 49 3e-06
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 47 2e-05
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 47 2e-05
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 47 2e-05
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 47 2e-05
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 47 2e-05
gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] 46 2e-05
gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] 46 2e-05
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 42 3e-04
gi|126723060 zinc finger CCCH-type containing 4 [Homo sapiens] 41 0.001
gi|4759156 small nuclear ribonucleoprotein polypeptide A [Homo s... 40 0.002
gi|110431370 espin [Homo sapiens] 40 0.002
gi|106879210 Src homology 2 domain containing adaptor protein B ... 40 0.002
gi|4503787 fyn-related kinase [Homo sapiens] 39 0.004
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur... 39 0.004
gi|150170670 piccolo isoform 2 [Homo sapiens] 39 0.004
gi|150378539 piccolo isoform 1 [Homo sapiens] 39 0.004
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 39 0.004
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 39 0.005
gi|47825361 non-specific cytotoxic cell receptor protein 1 homol... 39 0.005
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 38 0.006
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 38 0.006
>gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens]
Length = 225
Score = 459 bits (1181), Expect = e-130
Identities = 225/225 (100%), Positives = 225/225 (100%)
Query: 1 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL 60
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
Sbjct: 1 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL 60
Query: 61 SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV 120
SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
Sbjct: 61 SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV 120
Query: 121 LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR 180
LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
Sbjct: 121 LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR 180
Query: 181 PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL 225
PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
Sbjct: 181 PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL 225
>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
[Homo sapiens]
Length = 275
Score = 105 bits (261), Expect = 4e-23
Identities = 71/212 (33%), Positives = 101/212 (47%), Gaps = 13/212 (6%)
Query: 15 PLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSS 74
P T K + + + L+ESG+YW ++T EA L P GTFL+RDS+
Sbjct: 68 PAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 127
Query: 75 DQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAP 134
+ FTLSVKT G N+RI+ SF L S+ S + F V+ LV HY+ A
Sbjct: 128 HPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTAD 187
Query: 135 S---FPSPPTEPSSEVPEQ--PSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATL 189
+ P P P+ +P++ PS LP PP A + + LV S+ +L
Sbjct: 188 TRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVH-------LKLVQPFVRRSSARSL 240
Query: 190 QHLCRKTVNGHLDSYEKVTQLPGPIREFLDQY 221
QHLCR +N L + LP + ++L QY
Sbjct: 241 QHLCRLVIN-RLVADVDCLPLPRRMADYLRQY 271
>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
Length = 258
Score = 105 bits (261), Expect = 4e-23
Identities = 71/212 (33%), Positives = 101/212 (47%), Gaps = 13/212 (6%)
Query: 15 PLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSS 74
P T K + + + L+ESG+YW ++T EA L P GTFL+RDS+
Sbjct: 51 PAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 110
Query: 75 DQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAP 134
+ FTLSVKT G N+RI+ SF L S+ S + F V+ LV HY+ A
Sbjct: 111 HPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTAD 170
Query: 135 S---FPSPPTEPSSEVPEQ--PSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATL 189
+ P P P+ +P++ PS LP PP A + + LV S+ +L
Sbjct: 171 TRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVH-------LKLVQPFVRRSSARSL 223
Query: 190 QHLCRKTVNGHLDSYEKVTQLPGPIREFLDQY 221
QHLCR +N L + LP + ++L QY
Sbjct: 224 QHLCRLVIN-RLVADVDCLPLPRRMADYLRQY 254
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 89.7 bits (221), Expect = 2e-18
Identities = 58/188 (30%), Positives = 94/188 (50%), Gaps = 29/188 (15%)
Query: 34 VVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNL 93
+ A+R+L ++G+YW ++T EA L P GTFLIRDSS + T+SVKT +G NL
Sbjct: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95
Query: 94 RIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSA 153
RI+ + G F L S + +FD V+ L+ +Y V
Sbjct: 96 RIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY-------------------VQMCKDK 136
Query: 154 QPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGP 213
+ P +P ++Y L++PL ++ +LQHLCR T+N + + LP
Sbjct: 137 RTGPEAPRNGTVHLY---------LTKPLYTSAPSLQHLCRLTINKCTGAIWGL-PLPTR 186
Query: 214 IREFLDQY 221
++++L++Y
Sbjct: 187 LKDYLEEY 194
>gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
Length = 211
Score = 86.3 bits (212), Expect = 2e-17
Identities = 51/131 (38%), Positives = 68/131 (51%), Gaps = 12/131 (9%)
Query: 8 PAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGT 67
PA P DT R TF S ++Y+ + A L GFYW ++ A+ L AEP GT
Sbjct: 43 PAVPAPAPGDTHFR--TFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGT 100
Query: 68 FLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 127
FL+RDS + FF LSVK SG ++R+ + G F L S FDC+ +L+ HY
Sbjct: 101 FLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRES------FDCLFELLEHY 154
Query: 128 MPPP----GAP 134
+ P GAP
Sbjct: 155 VAAPRRMLGAP 165
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 65.5 bits (158), Expect = 4e-11
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 34/187 (18%)
Query: 38 VRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQC 97
++KL + G+YW +T EA L+ P G+FL+RDSSD R+ +LS ++ T + RI+
Sbjct: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEH 435
Query: 98 EGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLP 157
G FS P V ++ L+ H + +F S LP
Sbjct: 436 SNGRFSFYEQP----DVEGHTSIVDLIEHSIRDSENGAFCY-------------SRSRLP 478
Query: 158 GSPPRRAYYIYSGGEKIPLVLSRPLS--SNVATLQHLCRKTVNGH--LDSYEKVTQLPGP 213
GS A Y P+ L+ P+S V +LQ+LCR + + +D +K+ LP
Sbjct: 479 GS----ATY--------PVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKL-PLPNK 525
Query: 214 IREFLDQ 220
++++L +
Sbjct: 526 MKDYLQE 532
>gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens]
Length = 581
Score = 64.3 bits (155), Expect = 8e-11
Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 30/179 (16%)
Query: 37 AVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQ 96
++R+L++ G+YW + +A + L +P G+FL+RDSSD R+ +LS ++Q T + R++
Sbjct: 391 SLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRME 450
Query: 97 CEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPL 156
G+FSL P+ R V++ + + F +
Sbjct: 451 HYRGTFSLWCHPKFED---RCQSVVEFIKRAIMHSKNGKF------------LYFLRSRV 495
Query: 157 PGSPPRRAYYIYSGGEKIPLVLSRPLS--SNVATLQHLCRKTVNGHLDSYEKVTQLPGP 213
PG PP P+ L P+S SNV +LQHLCR + L + + LP P
Sbjct: 496 PGLPP------------TPVQLLYPVSRFSNVKSLQHLCRFRIR-QLVRIDHIPDLPLP 541
>gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 48.9 bits (115), Expect = 3e-06
Identities = 51/211 (24%), Positives = 91/211 (43%), Gaps = 47/211 (22%)
Query: 17 DTSLRLKT---FSSKSEY-QLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRD 72
D L+L+T + ++ +Y +V + ++ + YW + A LL +P GTFL+RD
Sbjct: 253 DEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRD 312
Query: 73 SSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPG 132
S+ + + F++S + S + + RI+ +FS + P + L+ HY P
Sbjct: 313 SAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPD---ITGLLEHYKDPSA 369
Query: 133 APSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHL 192
F +PL + PL+ + P S LQH+
Sbjct: 370 CMFF-----------------EPLLST---------------PLIRTFPFS-----LQHI 392
Query: 193 CRKTVNGHLDSYEKVTQLPGP--IREFLDQY 221
CR TV + +Y+ + LP P ++ +L +Y
Sbjct: 393 CR-TVICNCTTYDGIDALPIPSSMKLYLKEY 422
>gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 48.9 bits (115), Expect = 3e-06
Identities = 51/211 (24%), Positives = 91/211 (43%), Gaps = 47/211 (22%)
Query: 17 DTSLRLKT---FSSKSEY-QLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRD 72
D L+L+T + ++ +Y +V + ++ + YW + A LL +P GTFL+RD
Sbjct: 253 DEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRD 312
Query: 73 SSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPG 132
S+ + + F++S + S + + RI+ +FS + P + L+ HY P
Sbjct: 313 SAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPD---ITGLLEHYKDPSA 369
Query: 133 APSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHL 192
F +PL + PL+ + P S LQH+
Sbjct: 370 CMFF-----------------EPLLST---------------PLIRTFPFS-----LQHI 392
Query: 193 CRKTVNGHLDSYEKVTQLPGP--IREFLDQY 221
CR TV + +Y+ + LP P ++ +L +Y
Sbjct: 393 CR-TVICNCTTYDGIDALPIPSSMKLYLKEY 422
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 8/94 (8%)
Query: 35 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRH-FFTLSVKTQSGTKNL 93
+N LQ++ +YW ++ E N L GTFL+RD+S + H +TL+++ K +
Sbjct: 52 MNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLI 111
Query: 94 RIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 127
+I G + SDP + F V++L++HY
Sbjct: 112 KIFHRDGKYGF-SDPLT------FSSVVELINHY 138
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 8/94 (8%)
Query: 35 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRH-FFTLSVKTQSGTKNL 93
+N LQ++ +YW ++ E N L GTFL+RD+S + H +TL+++ K +
Sbjct: 22 MNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLI 81
Query: 94 RIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 127
+I G + SDP + F V++L++HY
Sbjct: 82 KIFHRDGKYGF-SDPLT------FSSVVELINHY 108
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 8/94 (8%)
Query: 35 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRH-FFTLSVKTQSGTKNL 93
+N LQ++ +YW ++ E N L GTFL+RD+S + H +TL+++ K +
Sbjct: 322 MNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLI 381
Query: 94 RIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 127
+I G + SDP + F V++L++HY
Sbjct: 382 KIFHRDGKYGF-SDPLT------FSSVVELINHY 408
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 46.6 bits (109), Expect = 2e-05
Identities = 28/88 (31%), Positives = 50/88 (56%), Gaps = 8/88 (9%)
Query: 41 LQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQ-RHFFTLSVKTQSGTKNLRIQCEG 99
LQ++ +YW ++ E N L P GTFL+RD+S + + +TL+++ K ++I
Sbjct: 60 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRD 119
Query: 100 GSFSLQSDPRSTQPVPRFDCVLKLVHHY 127
G + SDP + F+ V++L++HY
Sbjct: 120 GKYGF-SDPLT------FNSVVELINHY 140
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 46.6 bits (109), Expect = 2e-05
Identities = 28/88 (31%), Positives = 50/88 (56%), Gaps = 8/88 (9%)
Query: 41 LQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQ-RHFFTLSVKTQSGTKNLRIQCEG 99
LQ++ +YW ++ E N L P GTFL+RD+S + + +TL+++ K ++I
Sbjct: 60 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRD 119
Query: 100 GSFSLQSDPRSTQPVPRFDCVLKLVHHY 127
G + SDP + F+ V++L++HY
Sbjct: 120 GKYGF-SDPLT------FNSVVELINHY 140
>gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 46.2 bits (108), Expect = 2e-05
Identities = 29/91 (31%), Positives = 45/91 (49%), Gaps = 5/91 (5%)
Query: 47 YWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQS 106
YW + EA LL +P GTFL+RDS+ + + F++S + + + + RI+ +FS +
Sbjct: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
Query: 107 -DPRSTQPVPRFDCVLKLVHHYMPPPGAPSF 136
DP V V L+ HY P F
Sbjct: 442 HDP----CVFHSSTVTGLLEHYKDPSSCMFF 468
>gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 46.2 bits (108), Expect = 2e-05
Identities = 29/91 (31%), Positives = 45/91 (49%), Gaps = 5/91 (5%)
Query: 47 YWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQS 106
YW + EA LL +P GTFL+RDS+ + + F++S + + + + RI+ +FS +
Sbjct: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
Query: 107 -DPRSTQPVPRFDCVLKLVHHYMPPPGAPSF 136
DP V V L+ HY P F
Sbjct: 442 HDP----CVFHSSTVTGLLEHYKDPSSCMFF 468
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 42.4 bits (98), Expect = 3e-04
Identities = 26/88 (29%), Positives = 48/88 (54%), Gaps = 8/88 (9%)
Query: 41 LQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQ-RHFFTLSVKTQSGTKNLRIQCEG 99
LQ++ +YW ++ E N L P GTFL+RD+S + + +TL+++ K +++
Sbjct: 325 LQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRD 384
Query: 100 GSFSLQSDPRSTQPVPRFDCVLKLVHHY 127
G + S+P + F V+ L++HY
Sbjct: 385 GHYGF-SEPLT------FCSVVDLINHY 405
Score = 33.9 bits (76), Expect = 0.12
Identities = 26/86 (30%), Positives = 39/86 (45%), Gaps = 7/86 (8%)
Query: 42 QESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGS 101
+E +Y + +A +LS + GTFLIR+SS QR + SV TK+ I
Sbjct: 618 EERTWYVGKINRTQAEEMLSGKRDGTFLIRESS-QRGCYACSVVVDGDTKHCVIYRTATG 676
Query: 102 FSLQSDPRSTQPVPRFDCVLKLVHHY 127
F +P + + +LV HY
Sbjct: 677 FGF------AEPYNLYGSLKELVLHY 696
>gi|126723060 zinc finger CCCH-type containing 4 [Homo sapiens]
Length = 1303
Score = 40.8 bits (94), Expect = 0.001
Identities = 14/33 (42%), Positives = 19/33 (57%)
Query: 129 PPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPP 161
PPPG P+PP P + P P+ +P+ G PP
Sbjct: 510 PPPGVGLLPTPPRPPGPQAPTSPNGRPMQGGPP 542
Score = 30.4 bits (67), Expect = 1.3
Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 6/70 (8%)
Query: 128 MPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVA 187
+P P P P PT P+ P Q P P PP G ++P+ + PLS
Sbjct: 517 LPTPPRPPGPQAPTSPNGR-PMQGGPPPPPPPPPPP-----PGPPQMPMPVHEPLSPQQL 570
Query: 188 TLQHLCRKTV 197
Q + K +
Sbjct: 571 QQQDMYNKKI 580
Score = 28.9 bits (63), Expect = 3.7
Identities = 15/37 (40%), Positives = 17/37 (45%), Gaps = 3/37 (8%)
Query: 126 HYMPPPGAPS---FPSPPTEPSSEVPEQPSAQPLPGS 159
HY PG P FP P EP S P +P PG+
Sbjct: 720 HYEELPGEPGEHLFPEHPLEPDSFSEGGPPGRPKPGA 756
>gi|4759156 small nuclear ribonucleoprotein polypeptide A [Homo
sapiens]
Length = 282
Score = 39.7 bits (91), Expect = 0.002
Identities = 41/166 (24%), Positives = 67/166 (40%), Gaps = 22/166 (13%)
Query: 20 LRLKTFSSKSEYQLVVNAVRKLQESGFYWSA--VTGGEANLLLSAEPAGTFLIRDSSDQR 77
+R + F E NA+R +Q FY + + + + A+ GTF+ RD ++
Sbjct: 51 MRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREK 110
Query: 78 HFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQP-VPRFDCVLKLVHH------YMPP 130
K+Q + GG+ + + P +P +++HH YMPP
Sbjct: 111 R----KPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPP 166
Query: 131 PGA--PSFPSPPTEPSSEVPEQ-------PSAQPLPGSPPRRAYYI 167
PG P +P P +P Q P AQPL +PP ++
Sbjct: 167 PGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFL 212
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 39.7 bits (91), Expect = 0.002
Identities = 15/32 (46%), Positives = 18/32 (56%)
Query: 129 PPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSP 160
PPP PSFP PP P +++P P P P P
Sbjct: 430 PPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPP 461
>gi|106879210 Src homology 2 domain containing adaptor protein B
[Homo sapiens]
Length = 509
Score = 39.7 bits (91), Expect = 0.002
Identities = 22/87 (25%), Positives = 47/87 (54%), Gaps = 6/87 (6%)
Query: 41 LQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGG 100
L++ +Y A++ G+A LL ++L+R+S +H ++LS+++ G ++++
Sbjct: 405 LEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE 464
Query: 101 SFSLQSDPRSTQPVPRFDCVLKLVHHY 127
+ L Q P FD V +++H+Y
Sbjct: 465 KYVL------GQNSPPFDSVPEVIHYY 485
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 38.9 bits (89), Expect = 0.004
Identities = 26/68 (38%), Positives = 38/68 (55%), Gaps = 4/68 (5%)
Query: 39 RKLQESGFYWSAV--TGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQ 96
R LQ +++ A+ + E LL S G+FLIR+S Q+ F+LSV + K+ RI+
Sbjct: 109 RSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIK 168
Query: 97 --CEGGSF 102
EGG F
Sbjct: 169 RLDEGGFF 176
>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
plakophilin-related arm-repeat protein) [Homo sapiens]
Length = 1225
Score = 38.9 bits (89), Expect = 0.004
Identities = 42/143 (29%), Positives = 57/143 (39%), Gaps = 26/143 (18%)
Query: 32 QLVVNAVRKLQESGFY--WSAVTGGEANLL------LSAEPAGTFLIRDSSDQRHFFTLS 83
+LV + +R LQESG TG +LL L+++P G+F S L
Sbjct: 122 ELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALG 181
Query: 84 VKTQSG--TKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPT 141
T S + + + G SFS + R+ H P AP P PP
Sbjct: 182 ETTPSQLPARGTQARATGQSFSQGTTSRAG--------------HLAGPEPAPPPPPPPR 227
Query: 142 EPSSEVPEQPSAQPLPGSPPRRA 164
EP + P SA LP +PP A
Sbjct: 228 EPFA--PSLGSAFHLPDAPPAAA 248
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 38.9 bits (89), Expect = 0.004
Identities = 35/119 (29%), Positives = 45/119 (37%), Gaps = 7/119 (5%)
Query: 96 QCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQP 155
Q GS S+ S P +P R L + PPP P P PP P P P P
Sbjct: 2375 QLPSGSPSVSSLPAKPRPFFRSSS-LDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433
Query: 156 LPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPI 214
P P++ + S P+ + PL V TL+ NG L T P P+
Sbjct: 2434 KPTILPKKKLTVAS-----PVTTATPLFDAVTTLETTAVLRSNG-LPVTRICTTAPPPV 2486
Score = 29.6 bits (65), Expect = 2.2
Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 12/64 (18%)
Query: 128 MPPPGAPSFPSP-PTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNV 186
+P P P P P +P ++ P +QP P PP + P L++PL+
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQ-----------PSGLTKPLAQQP 346
Query: 187 ATLQ 190
T++
Sbjct: 347 GTVK 350
Score = 27.7 bits (60), Expect = 8.3
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 9/94 (9%)
Query: 124 VHHYMPPPGAPSFPSP--PTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRP 181
VH G+ S PSP P PS + S++P G+ + + +G +I L ++
Sbjct: 4650 VHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDGT--KVVSHPITG--EIQLQINYD 4705
Query: 182 LSS---NVATLQHLCRKTVNGHLDSYEKVTQLPG 212
L + ++ ++L + NG+ D + KV LPG
Sbjct: 4706 LGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPG 4739
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 38.9 bits (89), Expect = 0.004
Identities = 35/119 (29%), Positives = 45/119 (37%), Gaps = 7/119 (5%)
Query: 96 QCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQP 155
Q GS S+ S P +P R L + PPP P P PP P P P P
Sbjct: 2375 QLPSGSPSVSSLPAKPRPFFRSSS-LDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433
Query: 156 LPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPI 214
P P++ + S P+ + PL V TL+ NG L T P P+
Sbjct: 2434 KPTILPKKKLTVAS-----PVTTATPLFDAVTTLETTAVLRSNG-LPVTRICTTAPPPV 2486
Score = 29.6 bits (65), Expect = 2.2
Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 12/64 (18%)
Query: 128 MPPPGAPSFPSP-PTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNV 186
+P P P P P +P ++ P +QP P PP + P L++PL+
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQ-----------PSGLTKPLAQQP 346
Query: 187 ATLQ 190
T++
Sbjct: 347 GTVK 350
Score = 27.7 bits (60), Expect = 8.3
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 9/94 (9%)
Query: 124 VHHYMPPPGAPSFPSP--PTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRP 181
VH G+ S PSP P PS + S++P G+ + + +G +I L ++
Sbjct: 4650 VHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDGT--KVVSHPITG--EIQLQINYD 4705
Query: 182 LSS---NVATLQHLCRKTVNGHLDSYEKVTQLPG 212
L + ++ ++L + NG+ D + KV LPG
Sbjct: 4706 LGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPG 4739
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 38.9 bits (89), Expect = 0.004
Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 1/63 (1%)
Query: 41 LQESGFYWSAVTGGEAN-LLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEG 99
LQ+ G+Y +T A LLLS G++L+RDS++ ++LSV+ + K+ ++ G
Sbjct: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTG 89
Query: 100 GSF 102
SF
Sbjct: 90 YSF 92
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 38.5 bits (88), Expect = 0.005
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 8/83 (9%)
Query: 51 VTGGEA-NLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPR 109
+TG EA NLLL+ G+FL R S FTLSV+ +++IQ G + L
Sbjct: 11 ITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGG-- 68
Query: 110 STQPVPRFDCVLKLVHHYMPPPG 132
+F + +LV +YM G
Sbjct: 69 -----EKFATLAELVQYYMEHHG 86
Score = 32.3 bits (72), Expect = 0.34
Identities = 30/113 (26%), Positives = 49/113 (43%), Gaps = 19/113 (16%)
Query: 30 EYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPA-GTFLIRDSSDQRHFFTLSVKT-- 86
E + +N E F+ ++G EA LL+ + G+FL+R+S F LSV+T
Sbjct: 97 ELKYPLNCADPTSERWFH-GHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGD 155
Query: 87 --------QSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPP 131
+S ++ I+C+ + + RFD + LV HY P
Sbjct: 156 DKGESNDGKSKVTHVMIRCQELKYDVGGG-------ERFDSLTDLVEHYKKNP 201
>gi|47825361 non-specific cytotoxic cell receptor protein 1 homolog
[Homo sapiens]
Length = 275
Score = 38.5 bits (88), Expect = 0.005
Identities = 26/73 (35%), Positives = 32/73 (43%), Gaps = 16/73 (21%)
Query: 129 PPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPR--------RAYYIYSGGEKIP----- 175
PPP P PSPP+ PS PE P P P P + SGG ++P
Sbjct: 34 PPPSPPPLPSPPSLPSPAAPEAPEL-PEPAQPSEAHARQLLLEEWGPLSGGLELPQRLTW 92
Query: 176 --LVLSRPLSSNV 186
L+L RPL N+
Sbjct: 93 KLLLLRRPLYRNL 105
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 38.1 bits (87), Expect = 0.006
Identities = 22/72 (30%), Positives = 31/72 (43%)
Query: 42 QESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGS 101
+ S +YW ++ EA LL + G FL+RDSS + LSV S + I G
Sbjct: 9 ERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPR 68
Query: 102 FSLQSDPRSTQP 113
+ P P
Sbjct: 69 PPVPPSPAQPPP 80
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 38.1 bits (87), Expect = 0.006
Identities = 22/72 (30%), Positives = 31/72 (43%)
Query: 42 QESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGS 101
+ S +YW ++ EA LL + G FL+RDSS + LSV S + I G
Sbjct: 9 ERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPR 68
Query: 102 FSLQSDPRSTQP 113
+ P P
Sbjct: 69 PPVPPSPAQPPP 80
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,793,885
Number of Sequences: 37866
Number of extensions: 632305
Number of successful extensions: 10393
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 283
Number of HSP's successfully gapped in prelim test: 356
Number of HSP's that attempted gapping in prelim test: 6768
Number of HSP's gapped (non-prelim): 3317
length of query: 225
length of database: 18,247,518
effective HSP length: 99
effective length of query: 126
effective length of database: 14,498,784
effective search space: 1826846784
effective search space used: 1826846784
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.