BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4507255 signal transducer and activator of transcription 4 [Homo sapiens] (748 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4507255 signal transducer and activator of transcription 4 [H... 1500 0.0 gi|6274552 signal transducer and activator of transcription 1 is... 757 0.0 gi|21536301 signal transducer and activator of transcription 1 i... 749 0.0 gi|21618338 signal transducer and activator of transcription 3 i... 696 0.0 gi|21618340 signal transducer and activator of transcription 3 i... 696 0.0 gi|47458820 signal transducer and activator of transcription 3 i... 692 0.0 gi|4885615 signal transducer and activator of transcription 2 [H... 510 e-144 gi|21618344 signal transducer and activator of transcription 5B ... 310 3e-84 gi|21618342 signal transducer and activator of transcription 5A ... 291 2e-78 gi|23397678 signal transducer and activator of transcription 6 [... 207 2e-53 gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa... 44 5e-04 gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap... 44 5e-04 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 42 0.002 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 42 0.002 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 42 0.002 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 42 0.002 gi|212276078 leucine rich repeat (in FLII) interacting protein 1... 41 0.004 gi|126362969 Nck-associated protein 5 isoform 2 [Homo sapiens] 39 0.013 gi|126362967 Nck-associated protein 5 isoform 1 [Homo sapiens] 39 0.013 gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 39 0.013 gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 39 0.013 gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 39 0.013 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 39 0.023 gi|148612801 KIAA1009 protein [Homo sapiens] 39 0.023 gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo... 36 0.11 gi|24307983 FtsJ methyltransferase domain containing 2 [Homo sap... 36 0.15 gi|187761324 shootin1 isoform a [Homo sapiens] 36 0.15 gi|50511340 shootin1 isoform b [Homo sapiens] 36 0.15 gi|38570058 hypothetical protein LOC80129 [Homo sapiens] 35 0.19 gi|7705415 hook homolog 1 [Homo sapiens] 35 0.19 >gi|4507255 signal transducer and activator of transcription 4 [Homo sapiens] Length = 748 Score = 1500 bits (3883), Expect = 0.0 Identities = 748/748 (100%), Positives = 748/748 (100%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL Sbjct: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60 Query: 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN Sbjct: 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120 Query: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT Sbjct: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180 Query: 181 MDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKR 240 MDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKR Sbjct: 181 MDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKR 240 Query: 241 RQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHM 300 RQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHM Sbjct: 241 RQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHM 300 Query: 301 LERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVK 360 LERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVK Sbjct: 301 LERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVK 360 Query: 361 ASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCH 420 ASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCH Sbjct: 361 ASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCH 420 Query: 421 MVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNL 480 MVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNL Sbjct: 421 MVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNL 480 Query: 481 VFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCK 540 VFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCK Sbjct: 481 VFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCK 540 Query: 541 EHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFS 600 EHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFS Sbjct: 541 EHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFS 600 Query: 601 ESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKY 660 ESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKY Sbjct: 601 ESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKY 660 Query: 661 LYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPM 720 LYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPM Sbjct: 661 LYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPM 720 Query: 721 SPSVYAVLRENLSPTTIETAMKSPYSAE 748 SPSVYAVLRENLSPTTIETAMKSPYSAE Sbjct: 721 SPSVYAVLRENLSPTTIETAMKSPYSAE 748 >gi|6274552 signal transducer and activator of transcription 1 isoform alpha [Homo sapiens] Length = 750 Score = 757 bits (1954), Expect = 0.0 Identities = 398/736 (54%), Positives = 527/736 (71%), Gaps = 16/736 (2%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60 MSQW ++QQL+ KFLEQV Q YDD+FPMEIR LAQW+E QDWE A+N+ + ATI +L Sbjct: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60 Query: 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120 L QLD+Q R S E N LL HN+++ ++ LQ F +P+ ++++I +CL+EER+IL A Sbjct: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120 Query: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180 Q ++QS+ + ++Q+ ++ KV +K+ V E + K LEDLQDE+D++ KT+Q Sbjct: 121 RFNQAQ-SGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQN 179 Query: 181 MDQSDKNSAMVNQ--EVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDW 238 + A +Q E L L++M LD KRKE + K+ ++++ T+L N ++ +EL +W Sbjct: 180 REHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEW 239 Query: 239 KRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRT 298 KRRQQ ACIGGP + LDQLQN FT++AESL Q+R+QL+KLEE K TYE DPI + Sbjct: 240 KRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQ 299 Query: 299 HMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVK 358 + +R L L ++SFVVERQPCMPTHPQRPLVLKT +QFTVKLRLL+KL ELNY +K Sbjct: 300 VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLK 359 Query: 359 VKASIDKNVSTLSN----RRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGK 414 VK DK+V+ + R+F + GT+ K M++EES+NGSL+ EFRHLQ KE K+ AG + Sbjct: 360 VKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKN-AGTR 418 Query: 415 GNEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVST 474 NEG +VTEELHS++FETQ+C GL IDLET+SLPVV+ISNVSQLP+ WASI+WYN+ Sbjct: 419 TNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLV 478 Query: 475 NDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLT 534 + +NL FF PP A +QL EV+SWQFSS RGLN DQL+ML EKL ++ DG + Sbjct: 479 AEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIP 538 Query: 535 WAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGT 594 W +FCKE++ K+F FW W+E+IL+LIKKH+LPLW DG +MGF+SKE+ER LLKD+ PGT Sbjct: 539 WTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGT 598 Query: 595 FLLRFSE-SHLGGITFTWVDHSES-GEVRFHSVEPYNKGRLSALPFADILRDYKVIMAEN 652 FLLRFSE S G ITFTWV+ S++ GE FH+VEPY K LSA+ F DI+R+YKV+ AEN Sbjct: 599 FLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAEN 658 Query: 653 IPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTE-RGDK--GYVPSVFIPISTIRSDST 709 IPENPLKYLYP+I KD AFGK+Y S+P E P E G K GY+ + I +S + Sbjct: 659 IPENPLKYLYPNIDKDHAFGKYY-SRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRL 717 Query: 710 EPHSPSDLLPMSPSVY 725 + + +LLPMSP + Sbjct: 718 Q--TTDNLLPMSPEEF 731 >gi|21536301 signal transducer and activator of transcription 1 isoform beta [Homo sapiens] Length = 712 Score = 749 bits (1935), Expect = 0.0 Identities = 392/715 (54%), Positives = 517/715 (72%), Gaps = 14/715 (1%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60 MSQW ++QQL+ KFLEQV Q YDD+FPMEIR LAQW+E QDWE A+N+ + ATI +L Sbjct: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60 Query: 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120 L QLD+Q R S E N LL HN+++ ++ LQ F +P+ ++++I +CL+EER+IL A Sbjct: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120 Query: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180 Q ++QS+ + ++Q+ ++ KV +K+ V E + K LEDLQDE+D++ KT+Q Sbjct: 121 RFNQAQ-SGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQN 179 Query: 181 MDQSDKNSAMVNQ--EVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDW 238 + A +Q E L L++M LD KRKE + K+ ++++ T+L N ++ +EL +W Sbjct: 180 REHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEW 239 Query: 239 KRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRT 298 KRRQQ ACIGGP + LDQLQN FT++AESL Q+R+QL+KLEE K TYE DPI + Sbjct: 240 KRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQ 299 Query: 299 HMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVK 358 + +R L L ++SFVVERQPCMPTHPQRPLVLKT +QFTVKLRLL+KL ELNY +K Sbjct: 300 VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLK 359 Query: 359 VKASIDKNVSTLSN----RRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGK 414 VK DK+V+ + R+F + GT+ K M++EES+NGSL+ EFRHLQ KE K+ AG + Sbjct: 360 VKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKN-AGTR 418 Query: 415 GNEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVST 474 NEG +VTEELHS++FETQ+C GL IDLET+SLPVV+ISNVSQLP+ WASI+WYN+ Sbjct: 419 TNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLV 478 Query: 475 NDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLT 534 + +NL FF PP A +QL EV+SWQFSS RGLN DQL+ML EKL ++ DG + Sbjct: 479 AEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIP 538 Query: 535 WAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGT 594 W +FCKE++ K+F FW W+E+IL+LIKKH+LPLW DG +MGF+SKE+ER LLKD+ PGT Sbjct: 539 WTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGT 598 Query: 595 FLLRFSE-SHLGGITFTWVDHSES-GEVRFHSVEPYNKGRLSALPFADILRDYKVIMAEN 652 FLLRFSE S G ITFTWV+ S++ GE FH+VEPY K LSA+ F DI+R+YKV+ AEN Sbjct: 599 FLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAEN 658 Query: 653 IPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTE-RGDK--GYVPSVFIPISTI 704 IPENPLKYLYP+I KD AFGK+Y S+P E P E G K GY+ + I +S + Sbjct: 659 IPENPLKYLYPNIDKDHAFGKYY-SRPKEAPEPMELDGPKGTGYIKTELISVSEV 712 >gi|21618338 signal transducer and activator of transcription 3 isoform 2 [Homo sapiens] Length = 769 Score = 696 bits (1795), Expect = 0.0 Identities = 357/734 (48%), Positives = 502/734 (68%), Gaps = 19/734 (2%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60 M+QWNQ+QQL+ ++LEQ+ Q Y D+FPME+R LA WIE+QDW A++ E+ AT++ NL Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60 Query: 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL-AAA 119 L ++D+Q R +E N+L HNL+RI++ LQ ++ PM +A +++ CL EE R+L AA Sbjct: 61 LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120 Query: 120 NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQ 179 QG ++ V+E+Q+ +E + ++ VQ EQ K +E+LQD+FD+ YKT++ Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180 Query: 180 TM----DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235 + D + N ++ Q++ L++ML +LD R+ +S++ ++ + + T+ EEL Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240 Query: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295 DWKRRQQIACIGGP + LD+L+N T LAES Q R+Q++KLEE K++Y+GDPI Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300 Query: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355 R + ER+ L NL K++FVVERQPCMP HP RPLV+KT +QFT K+RLL+K PELNY Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360 Query: 356 QVKVKASIDKNVSTLS----NRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSA 411 Q+K+K IDK+ ++ +R+F + GTN K M++EES+NGSLS EF+HL +E + Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420 Query: 412 GGKGN-EGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWY 470 GG+ N + +VTEELH ITFET++ GL IDLET SLPVV+ISN+ Q+PNAWASI+WY Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480 Query: 471 NVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQS-SYS 529 N+ TN+ +N+ FF PP T Q+ EV+SWQFSS RGL+ +QL LAEKL +YS Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540 Query: 530 DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKD 589 +TWAKFCKE++ GK F+FW WL+ I+DL+KK+IL LW +GY+MGF+SKE+ER +L Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600 Query: 590 KMPGTFLLRFSESHL-GGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVI 648 K PGTFLLRFSES GG+TFTWV+ SG+ + SVEPY K +L+ + FA+I+ YK++ Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660 Query: 649 MAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDS 708 A NI +PL YLYPDIPK++AFGK Y + + G Y+ + FI ++ + Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGK-YCRPESQEHPEADPGAAPYLKTKFICVTPTTCSN 719 Query: 709 TEPHSPSDLLPMSP 722 T LPMSP Sbjct: 720 TID------LPMSP 727 >gi|21618340 signal transducer and activator of transcription 3 isoform 1 [Homo sapiens] Length = 770 Score = 696 bits (1795), Expect = 0.0 Identities = 356/734 (48%), Positives = 501/734 (68%), Gaps = 18/734 (2%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60 M+QWNQ+QQL+ ++LEQ+ Q Y D+FPME+R LA WIE+QDW A++ E+ AT++ NL Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60 Query: 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL-AAA 119 L ++D+Q R +E N+L HNL+RI++ LQ ++ PM +A +++ CL EE R+L AA Sbjct: 61 LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120 Query: 120 NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQ 179 QG ++ V+E+Q+ +E + ++ VQ EQ K +E+LQD+FD+ YKT++ Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180 Query: 180 TM----DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235 + D + N ++ Q++ L++ML +LD R+ +S++ ++ + + T+ EEL Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240 Query: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295 DWKRRQQIACIGGP + LD+L+N T LAES Q R+Q++KLEE K++Y+GDPI Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300 Query: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355 R + ER+ L NL K++FVVERQPCMP HP RPLV+KT +QFT K+RLL+K PELNY Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360 Query: 356 QVKVKASIDKNVSTLS----NRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSA 411 Q+K+K IDK+ ++ +R+F + GTN K M++EES+NGSLS EF+HL +E + Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420 Query: 412 GGKGN-EGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWY 470 GG+ N + +VTEELH ITFET++ GL IDLET SLPVV+ISN+ Q+PNAWASI+WY Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480 Query: 471 NVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQS-SYS 529 N+ TN+ +N+ FF PP T Q+ EV+SWQFSS RGL+ +QL LAEKL +YS Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540 Query: 530 DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKD 589 +TWAKFCKE++ GK F+FW WL+ I+DL+KK+IL LW +GY+MGF+SKE+ER +L Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600 Query: 590 KMPGTFLLRFSESHL-GGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVI 648 K PGTFLLRFSES GG+TFTWV+ SG+ + SVEPY K +L+ + FA+I+ YK++ Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660 Query: 649 MAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDS 708 A NI +PL YLYPDIPK++AFGK+ + E Y+ + FI ++ + Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN 720 Query: 709 TEPHSPSDLLPMSP 722 T LPMSP Sbjct: 721 TID------LPMSP 728 >gi|47458820 signal transducer and activator of transcription 3 isoform 3 [Homo sapiens] Length = 722 Score = 692 bits (1787), Expect = 0.0 Identities = 350/714 (49%), Positives = 494/714 (69%), Gaps = 12/714 (1%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60 M+QWNQ+QQL+ ++LEQ+ Q Y D+FPME+R LA WIE+QDW A++ E+ AT++ NL Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60 Query: 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL-AAA 119 L ++D+Q R +E N+L HNL+RI++ LQ ++ PM +A +++ CL EE R+L AA Sbjct: 61 LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120 Query: 120 NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQ 179 QG ++ V+E+Q+ +E + ++ VQ EQ K +E+LQD+FD+ YKT++ Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180 Query: 180 TM----DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235 + D + N ++ Q++ L++ML +LD R+ +S++ ++ + + T+ EEL Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240 Query: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295 DWKRRQQIACIGGP + LD+L+N T LAES Q R+Q++KLEE K++Y+GDPI Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300 Query: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355 R + ER+ L NL K++FVVERQPCMP HP RPLV+KT +QFT K+RLL+K PELNY Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360 Query: 356 QVKVKASIDKNVSTLS----NRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSA 411 Q+K+K IDK+ ++ +R+F + GTN K M++EES+NGSLS EF+HL +E + Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420 Query: 412 GGKGN-EGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWY 470 GG+ N + +VTEELH ITFET++ GL IDLET SLPVV+ISN+ Q+PNAWASI+WY Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480 Query: 471 NVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQS-SYS 529 N+ TN+ +N+ FF PP T Q+ EV+SWQFSS RGL+ +QL LAEKL +YS Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540 Query: 530 DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKD 589 +TWAKFCKE++ GK F+FW WL+ I+DL+KK+IL LW +GY+MGF+SKE+ER +L Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600 Query: 590 KMPGTFLLRFSESHL-GGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVI 648 K PGTFLLRFSES GG+TFTWV+ SG+ + SVEPY K +L+ + FA+I+ YK++ Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660 Query: 649 MAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPIS 702 A NI +PL YLYPDIPK++AFGK+ + E Y+ + FI ++ Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVT 714 >gi|4885615 signal transducer and activator of transcription 2 [Homo sapiens] Length = 851 Score = 510 bits (1313), Expect = e-144 Identities = 290/685 (42%), Positives = 427/685 (62%), Gaps = 11/685 (1%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNF-PMEIRHLLAQWIENQDWEAAS--NNETMATILL 57 M+QW +Q L+ F +Q+ Q Y + P++IR LA WIE+Q+W+ A+ ++++ AT+L Sbjct: 1 MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLF 60 Query: 58 QNLLIQLDEQLGRVSKE-KNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116 + L QL+ + GR S++ ++LLL HNL++ + +Q F +P +A +I N L EE+RIL Sbjct: 61 FHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQ-PFSQDPTQLAEMIFNLLLEEKRIL 119 Query: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176 A E L++ V +Q +E ++ ++ ++ + L+D QD F +RYK Sbjct: 120 IQAQRAQLEQGEPVLETP-VESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYK 178 Query: 177 TIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQ 236 IQ ++ +E LQE LN LD +RKE L ++ L+ +L+ +L+ Sbjct: 179 -IQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIE-LLLPKLE 236 Query: 237 DWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQ 296 +WK +QQ ACI P+ +GL+QL+ FT A+ LF LR+ L++L+ S ++Y+ DP+ Sbjct: 237 EWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLTKG 296 Query: 297 RTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQ 356 +VT L+ L +FVVE QPCMP P RPL+LKT +FTV+ RLL++L E N Sbjct: 297 VDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNES 356 Query: 357 VKVKASIDKNVSTLSN-RRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKG 415 + V+ SID+N L R+F + +N K ++ E+ + L +F +L E +S GKG Sbjct: 357 LTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKG 416 Query: 416 -NEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVST 474 N+G VTEELH I+F + GL +L+T +LPVV+ISN++QL AWAS++W+N+ + Sbjct: 417 SNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLS 476 Query: 475 NDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYS-DGHL 533 + QN FF+NPP A S L +SWQFSSYVGRGLNSDQL ML KL Q+ + D L Sbjct: 477 PNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLL 536 Query: 534 TWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPG 593 +WA F K P FWTWL+ IL+L+ H+ LW DG +MGFVS+ +ER LLK M G Sbjct: 537 SWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSG 596 Query: 594 TFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENI 653 TFLLRFSES GGIT +WV+H + +V +SV+PY K L +LP +I+R Y+++ ENI Sbjct: 597 TFLLRFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENI 656 Query: 654 PENPLKYLYPDIPKDKAFGKHYSSQ 678 PENPL++LYP IP+D+AFG +Y + Sbjct: 657 PENPLRFLYPRIPRDEAFGCYYQEK 681 >gi|21618344 signal transducer and activator of transcription 5B [Homo sapiens] Length = 787 Score = 310 bits (794), Expect = 3e-84 Identities = 229/732 (31%), Positives = 362/732 (49%), Gaps = 70/732 (9%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAAS----NNETMATIL 56 M+ W Q QQL+ + L Q+ Y +FP+E+RH L+QWIE+Q W++ AT L Sbjct: 1 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL 60 Query: 57 LQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116 L+ L+ +L ++ E LL L LQ + PM + I + L E+R++ Sbjct: 61 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120 Query: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176 AN G + ++S++ + ++ Q TE + K L+ Q+ F +Y+ Sbjct: 121 REAN---NGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQ 177 Query: 177 T-------------IQTMDQSDKNSAMVNQEVLT---LQEMLNSLDFKRKEALSKMTQII 220 + ++ + +A+ ++V LQ +L R E K + + Sbjct: 178 ESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTL 237 Query: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280 +L +EL WKRRQQ+A GGP LD LQ+ LAE ++Q R+Q+ + E Sbjct: 238 QLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAE 297 Query: 281 EQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQF 340 ++ G P+ + +T +I L ++F++E+QP P VLKT +F Sbjct: 298 HLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKF 348 Query: 341 TVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLSNRRFVLCGTNVKAMSIEE--SS 391 +RLL+ KL +VKA+I K++ N R G + + E + Sbjct: 349 AATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQA 408 Query: 392 NGSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSL 449 G+LS FR++ K +K S G VTEE +I FE+Q + G L ++T SL Sbjct: 409 TGTLSAHFRNMSLKRIKRS----DRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSL 464 Query: 450 PVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--G 507 PVV+I + SQ NA A+++W N + V F P QL E ++ +F + V Sbjct: 465 PVVVIVHGSQDNNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSN 522 Query: 508 RGLNSDQLHMLAEKLTVQSS-----YSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIK 562 RGL + L LA+KL SS YS ++W++F +E+LPG+++TFW W + +++++K Sbjct: 523 RGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLK 582 Query: 563 KHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRF 622 KH+ P W DG ++GFV+K++ LL +K GTFLLRFS+S +GGIT W +S E F Sbjct: 583 KHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSQERMF 640 Query: 623 HSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEV 682 ++ P+ S AD L D N L Y++PD PKD+ + K+Y+ PCE Sbjct: 641 WNLMPFTTRDFSIRSLADRLGDL----------NYLIYVFPDRPKDEVYSKYYTPVPCES 690 Query: 683 SRPTERGDKGYV 694 + T + GYV Sbjct: 691 A--TAKAVDGYV 700 >gi|21618342 signal transducer and activator of transcription 5A [Homo sapiens] Length = 794 Score = 291 bits (744), Expect = 2e-78 Identities = 218/714 (30%), Positives = 350/714 (49%), Gaps = 68/714 (9%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAAS----NNETMATIL 56 M+ W Q QQL+ L Q+ Y +FP+E+RH LAQWIE+Q W+A + AT L Sbjct: 1 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60 Query: 57 LQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116 L+ L+ +L ++ E LL L LQ + P+ + I + L E+R++ Sbjct: 61 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120 Query: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176 AN P + ++S++ + ++ Q TE + K L+ Q+ F +Y+ Sbjct: 121 REANN-CSSPA--GILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQ 177 Query: 177 T-------------IQTMDQSDKNSAMVNQEVLT---LQEMLNSLDFKRKEALSKMTQII 220 + ++ + +A+ ++V LQ +L R E K + + Sbjct: 178 ESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTL 237 Query: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280 +L +EL WKRRQQ+A GGP LD LQ+ LAE ++Q R+Q+ + E Sbjct: 238 QLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAE 297 Query: 281 EQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQF 340 ++ G P+ + +T +I L ++F++E+QP P VLKT +F Sbjct: 298 HLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKF 348 Query: 341 TVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLSNRRFVLCGTNVKAMSIEE--SS 391 +RLL+ KL +VKA+I K++ N R G + + E + Sbjct: 349 AATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQA 408 Query: 392 NGSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSL 449 G+LS FR++ K +K + G VTEE ++ FE+Q + L ++T SL Sbjct: 409 TGTLSAHFRNMSLKRIKRA----DRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSL 464 Query: 450 PVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--G 507 PVV+I + SQ NA A+++W N + V F P QL E ++ +F + V Sbjct: 465 PVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSN 522 Query: 508 RGLNSDQLHMLAEKLTVQSS-----YSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIK 562 RGL + L LA+KL SS YS ++W++F +E+LPG ++TFW W + +++++K Sbjct: 523 RGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLK 582 Query: 563 KHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRF 622 KH P W DG ++GFV+K++ LL +K GTFLLRFS+S +GGIT W +S E Sbjct: 583 KHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPERNL 640 Query: 623 HSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYS 676 +++P+ S AD L D ++ Y++PD PKD+ F K+Y+ Sbjct: 641 WNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRPKDEVFSKYYT 684 >gi|23397678 signal transducer and activator of transcription 6 [Homo sapiens] Length = 847 Score = 207 bits (528), Expect = 2e-53 Identities = 203/756 (26%), Positives = 328/756 (43%), Gaps = 120/756 (15%) Query: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNET----MATIL 56 MS W V ++ E+V + Y D FP +RHLL W+E+Q WE ++ +A+ L Sbjct: 1 MSLWGLVSKMPP---EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56 Query: 57 LQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116 L + + L +G + +L + L+ + +P+ + L+ E++ + Sbjct: 57 LSDTVQHLQASVGEQGEGSTIL------QHISTLESIYQRDPLKLVATFRQILQGEKKAV 110 Query: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176 + P + R ++H+V I E LQ + Sbjct: 111 MEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIH----------LLREALQKGAEAGQV 160 Query: 177 TIQTMDQSDKNSAMVNQEV-LTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235 ++ ++ ++ N ++ + + LQE L+ + ++++ + Sbjct: 161 SLHSLIETPANGTGPSEALAMLLQETTGELEAAK-------------------ALVLKRI 201 Query: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295 Q WKR+QQ+A G P L LQ ESL + QL Q G+ P Sbjct: 202 QIWKRQQQLAGNGAPFEESLAPLQE----RCESLVDIYSQL-----QQEVGAAGGELEPK 252 Query: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355 R + R+ ++ L + F+VE+QP P VLKT +F +R L+ L L Sbjct: 253 TRASLTGRLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGLRFLGA 304 Query: 356 QVK---VKASI--DKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVE-----------F 399 K V+A + +K LS V G A S E N ++ +E F Sbjct: 305 PAKPPLVRADMVTEKQARELS----VPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF 360 Query: 400 RHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSLPVVMISNV 457 ++L K++K +G VTEE ++ F L L I L+ SLP+V+I + Sbjct: 361 KNLLLKKIKRCE----RKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHG 416 Query: 458 SQLPNAWASIIWYNV-STNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVG--RGLNSDQ 514 +Q NA A+I+W N S D V P ++ E ++ +F + VG RGL + Sbjct: 417 NQDNNAKATILWDNAFSEMDRVPFVVAERVP---WEKMCETLNLKFMAEVGTNRGLLPEH 473 Query: 515 LHMLAEKLTVQSSYS-----DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLW 569 LA+K+ +S S ++W++F KE L G+ FTFW W + +LDL K+ + W Sbjct: 474 FLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYW 533 Query: 570 IDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYN 629 D ++GF+SK+ LL ++ GTFLLRFS+S +GGIT V + G + +++P++ Sbjct: 534 SDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFS 593 Query: 630 KGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERG 689 LS D +RD LK LYP PKD+AF HY +P + G Sbjct: 594 AKDLSIRSLGDRIRDLA----------QLKNLYPKKPKDEAFRSHY--------KPEQMG 635 Query: 690 --DKGYVPSVFIPISTIRSDSTEPHSPSDLLPMSPS 723 +GYVP+ T+ D P + M PS Sbjct: 636 KDGRGYVPATI--KMTVERDQPLPTPELQMPTMVPS 669 >gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sapiens] Length = 1185 Score = 43.9 bits (102), Expect = 5e-04 Identities = 59/258 (22%), Positives = 98/258 (37%), Gaps = 16/258 (6%) Query: 56 LLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCL--REER 113 L + L L ++ ++KE N+ L+R ++ + K N + + CL R ER Sbjct: 78 LQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHER 137 Query: 114 RI-LAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFD 172 + + Q P S + + + EH A + + + L++E Sbjct: 138 SLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELG 197 Query: 173 YRYKTIQTMDQSDKNSAMVNQEVLTL---QEMLNSLDFKRKEALSKMTQIIHETDLLMNT 229 +K + + + + + VL + QE S KR S + HE DL Sbjct: 198 ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKR----SSDGSLSHEEDLAKVI 253 Query: 230 MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYE 289 L E + R Q + L L + T L E L R+ L K EE +TK+ + Sbjct: 254 ELQEIISKQSREQS------QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRD 307 Query: 290 GDPIPMQRTHMLERVTFL 307 Q+ M ER+T L Sbjct: 308 VREAMAQKEDMEERITTL 325 >gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sapiens] Length = 1202 Score = 43.9 bits (102), Expect = 5e-04 Identities = 59/258 (22%), Positives = 98/258 (37%), Gaps = 16/258 (6%) Query: 56 LLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCL--REER 113 L + L L ++ ++KE N+ L+R ++ + K N + + CL R ER Sbjct: 78 LQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHER 137 Query: 114 RI-LAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFD 172 + + Q P S + + + EH A + + + L++E Sbjct: 138 SLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELG 197 Query: 173 YRYKTIQTMDQSDKNSAMVNQEVLTL---QEMLNSLDFKRKEALSKMTQIIHETDLLMNT 229 +K + + + + + VL + QE S KR S + HE DL Sbjct: 198 ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKR----SSDGSLSHEEDLAKVI 253 Query: 230 MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYE 289 L E + R Q + L L + T L E L R+ L K EE +TK+ + Sbjct: 254 ELQEIISKQSREQS------QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRD 307 Query: 290 GDPIPMQRTHMLERVTFL 307 Q+ M ER+T L Sbjct: 308 VREAMAQKEDMEERITTL 325 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 42.0 bits (97), Expect = 0.002 Identities = 40/174 (22%), Positives = 82/174 (47%), Gaps = 11/174 (6%) Query: 110 REERRILAAANMPVQGPLEK-SLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQ 168 R++R + AAA ++G L+ LQ+ S ++ + AIK ++ Q + +L+ Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSA------IKGREEAIKQLRKLQAQMKDFQRELE 1662 Query: 169 DEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMN 228 D R + T +++K + + +++ LQE L + + RK+A + ++ E L + Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE--LASS 1720 Query: 229 TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQ 282 LQD KRR + L L++ Q +++ + + +Q E+L + Sbjct: 1721 LSGRNALQDEKRRLEARI--AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772 Score = 33.9 bits (76), Expect = 0.57 Identities = 47/264 (17%), Positives = 105/264 (39%), Gaps = 39/264 (14%) Query: 58 QNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILA 117 +N L +L+++ ++++EKNLL ++ LQ + ++ EE R+ Sbjct: 872 ENELKELEQKHSQLTEEKNLL--------QEQLQAE---TELYAEA-------EEMRVRL 913 Query: 118 AANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKT 177 AA + +++ E R + + K + QM + + E L++E R K Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE----EQLEEEEAARQKL 969 Query: 178 IQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRK-----------------EALSKMTQII 220 ++ + E+L + + N L +RK E +T++ Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029 Query: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280 ++ + +++ + + ++ K RQ++ + L L + +L+ QL K E Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089 Query: 281 EQSTKMTYEGDPIPMQRTHMLERV 304 E+ D Q+ + L+++ Sbjct: 1090 EELQAALARLDDEIAQKNNALKKI 1113 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 42.0 bits (97), Expect = 0.002 Identities = 40/174 (22%), Positives = 82/174 (47%), Gaps = 11/174 (6%) Query: 110 REERRILAAANMPVQGPLEK-SLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQ 168 R++R + AAA ++G L+ LQ+ S ++ + AIK ++ Q + +L+ Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSA------IKGREEAIKQLRKLQAQMKDFQRELE 1669 Query: 169 DEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMN 228 D R + T +++K + + +++ LQE L + + RK+A + ++ E L + Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE--LASS 1727 Query: 229 TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQ 282 LQD KRR + L L++ Q +++ + + +Q E+L + Sbjct: 1728 LSGRNALQDEKRRLEARI--AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779 Score = 33.9 bits (76), Expect = 0.57 Identities = 47/264 (17%), Positives = 105/264 (39%), Gaps = 39/264 (14%) Query: 58 QNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILA 117 +N L +L+++ ++++EKNLL ++ LQ + ++ EE R+ Sbjct: 879 ENELKELEQKHSQLTEEKNLL--------QEQLQAE---TELYAEA-------EEMRVRL 920 Query: 118 AANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKT 177 AA + +++ E R + + K + QM + + E L++E R K Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE----EQLEEEEAARQKL 976 Query: 178 IQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRK-----------------EALSKMTQII 220 ++ + E+L + + N L +RK E +T++ Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036 Query: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280 ++ + +++ + + ++ K RQ++ + L L + +L+ QL K E Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096 Query: 281 EQSTKMTYEGDPIPMQRTHMLERV 304 E+ D Q+ + L+++ Sbjct: 1097 EELQAALARLDDEIAQKNNALKKI 1120 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 42.0 bits (97), Expect = 0.002 Identities = 40/174 (22%), Positives = 82/174 (47%), Gaps = 11/174 (6%) Query: 110 REERRILAAANMPVQGPLEK-SLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQ 168 R++R + AAA ++G L+ LQ+ S ++ + AIK ++ Q + +L+ Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSA------IKGREEAIKQLRKLQAQMKDFQRELE 1669 Query: 169 DEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMN 228 D R + T +++K + + +++ LQE L + + RK+A + ++ E L + Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE--LASS 1727 Query: 229 TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQ 282 LQD KRR + L L++ Q +++ + + +Q E+L + Sbjct: 1728 LSGRNALQDEKRRLEARI--AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779 Score = 33.9 bits (76), Expect = 0.57 Identities = 47/264 (17%), Positives = 105/264 (39%), Gaps = 39/264 (14%) Query: 58 QNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILA 117 +N L +L+++ ++++EKNLL ++ LQ + ++ EE R+ Sbjct: 879 ENELKELEQKHSQLTEEKNLL--------QEQLQAE---TELYAEA-------EEMRVRL 920 Query: 118 AANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKT 177 AA + +++ E R + + K + QM + + E L++E R K Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE----EQLEEEEAARQKL 976 Query: 178 IQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRK-----------------EALSKMTQII 220 ++ + E+L + + N L +RK E +T++ Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036 Query: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280 ++ + +++ + + ++ K RQ++ + L L + +L+ QL K E Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096 Query: 281 EQSTKMTYEGDPIPMQRTHMLERV 304 E+ D Q+ + L+++ Sbjct: 1097 EELQAALARLDDEIAQKNNALKKI 1120 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 42.0 bits (97), Expect = 0.002 Identities = 40/174 (22%), Positives = 82/174 (47%), Gaps = 11/174 (6%) Query: 110 REERRILAAANMPVQGPLEK-SLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQ 168 R++R + AAA ++G L+ LQ+ S ++ + AIK ++ Q + +L+ Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSA------IKGREEAIKQLRKLQAQMKDFQRELE 1662 Query: 169 DEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMN 228 D R + T +++K + + +++ LQE L + + RK+A + ++ E L + Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE--LASS 1720 Query: 229 TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQ 282 LQD KRR + L L++ Q +++ + + +Q E+L + Sbjct: 1721 LSGRNALQDEKRRLEARI--AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772 Score = 33.9 bits (76), Expect = 0.57 Identities = 47/264 (17%), Positives = 105/264 (39%), Gaps = 39/264 (14%) Query: 58 QNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILA 117 +N L +L+++ ++++EKNLL ++ LQ + ++ EE R+ Sbjct: 872 ENELKELEQKHSQLTEEKNLL--------QEQLQAE---TELYAEA-------EEMRVRL 913 Query: 118 AANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKT 177 AA + +++ E R + + K + QM + + E L++E R K Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE----EQLEEEEAARQKL 969 Query: 178 IQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRK-----------------EALSKMTQII 220 ++ + E+L + + N L +RK E +T++ Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029 Query: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280 ++ + +++ + + ++ K RQ++ + L L + +L+ QL K E Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089 Query: 281 EQSTKMTYEGDPIPMQRTHMLERV 304 E+ D Q+ + L+++ Sbjct: 1090 EELQAALARLDDEIAQKNNALKKI 1113 >gi|212276078 leucine rich repeat (in FLII) interacting protein 1 isoform 1 [Homo sapiens] Length = 640 Score = 41.2 bits (95), Expect = 0.004 Identities = 42/217 (19%), Positives = 92/217 (42%), Gaps = 19/217 (8%) Query: 5 NQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQL 64 +Q+Q +E K+++ + + D +E ++ A + N + N L+++L++L Sbjct: 272 DQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAM-VSNAQLDNEKTNFMYQVDTLKDMLLEL 330 Query: 65 DEQLG---RVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANM 121 +EQL R +EKN K +LQ +F + L++ +L Sbjct: 331 EEQLAESRRQYEEKNKEFERE-KHAHSILQFQF--------AEVKEALKQREEMLEEIRQ 381 Query: 122 PVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTM 181 Q + S + E + K+ A++ + + +DL++E + Sbjct: 382 LQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREE------VVMLK 435 Query: 182 DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQ 218 ++ K+ ++N E+ T E ++L+ + +KMT+ Sbjct: 436 EELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTK 472 >gi|126362969 Nck-associated protein 5 isoform 2 [Homo sapiens] Length = 590 Score = 39.3 bits (90), Expect = 0.013 Identities = 52/245 (21%), Positives = 98/245 (40%), Gaps = 53/245 (21%) Query: 57 LQNLLIQLDEQLGRVSKEKNLLLIHNLKR--IRKVLQGKFHGNPMHVAVVISNCLREERR 114 +++LL QL+EQ + +EK L + L+R ++ +G H +H L EER Sbjct: 32 IEHLLTQLEEQHRSLWREK--LAVARLQREVAQRTSEGAMHEKLIHE-------LEEERH 82 Query: 115 ILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYR 174 + + EK LQ ++ +N +QM LQ +F Sbjct: 83 LRLQS--------EKRLQEVTLESE-----------RNRIQM--------RSLQQQFSRM 115 Query: 175 YKTIQTMDQSDKNSAMVNQE---VLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNT-- 229 +T++ + QS + +E ++ QE L+ + K KEAL + ++ E ++ Sbjct: 116 EETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSST 175 Query: 230 --------MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEE 281 +L+E L+ + + N +Q + C +A + Q + L E Sbjct: 176 DEGKEKTKLLLERLKALEAENSALALEN--ENQREQYERCLDEVANQVVQALLTQKDLRE 233 Query: 282 QSTKM 286 + K+ Sbjct: 234 ECVKL 238 >gi|126362967 Nck-associated protein 5 isoform 1 [Homo sapiens] Length = 1909 Score = 39.3 bits (90), Expect = 0.013 Identities = 52/245 (21%), Positives = 98/245 (40%), Gaps = 53/245 (21%) Query: 57 LQNLLIQLDEQLGRVSKEKNLLLIHNLKR--IRKVLQGKFHGNPMHVAVVISNCLREERR 114 +++LL QL+EQ + +EK L + L+R ++ +G H +H L EER Sbjct: 32 IEHLLTQLEEQHRSLWREK--LAVARLQREVAQRTSEGAMHEKLIHE-------LEEERH 82 Query: 115 ILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYR 174 + + EK LQ ++ +N +QM LQ +F Sbjct: 83 LRLQS--------EKRLQEVTLESE-----------RNRIQM--------RSLQQQFSRM 115 Query: 175 YKTIQTMDQSDKNSAMVNQE---VLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNT-- 229 +T++ + QS + +E ++ QE L+ + K KEAL + ++ E ++ Sbjct: 116 EETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSST 175 Query: 230 --------MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEE 281 +L+E L+ + + N +Q + C +A + Q + L E Sbjct: 176 DEGKEKTKLLLERLKALEAENSALALEN--ENQREQYERCLDEVANQVVQALLTQKDLRE 233 Query: 282 QSTKM 286 + K+ Sbjct: 234 ECVKL 238 >gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] Length = 2003 Score = 39.3 bits (90), Expect = 0.013 Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%) Query: 110 REERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQD 169 R++R + AA ++G LE+ L++ S Q E A+K +M Q + ++++ Sbjct: 1634 RKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEE----AVKQLRKMQAQMKELWREVEE 1688 Query: 170 EFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHE--TDLLM 227 R + +S+K + EVL LQE L + D R++A ++ E L Sbjct: 1689 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1748 Query: 228 NTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279 ++EE ++Q+ G L L++ Q+ LL + +L Q+E L Sbjct: 1749 KAAILEE------KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1794 >gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] Length = 1995 Score = 39.3 bits (90), Expect = 0.013 Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%) Query: 110 REERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQD 169 R++R + AA ++G LE+ L++ S Q E A+K +M Q + ++++ Sbjct: 1626 RKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEE----AVKQLRKMQAQMKELWREVEE 1680 Query: 170 EFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHE--TDLLM 227 R + +S+K + EVL LQE L + D R++A ++ E L Sbjct: 1681 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1740 Query: 228 NTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279 ++EE ++Q+ G L L++ Q+ LL + +L Q+E L Sbjct: 1741 KAAILEE------KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1786 >gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] Length = 2036 Score = 39.3 bits (90), Expect = 0.013 Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%) Query: 110 REERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQD 169 R++R + AA ++G LE+ L++ S Q E A+K +M Q + ++++ Sbjct: 1667 RKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEE----AVKQLRKMQAQMKELWREVEE 1721 Query: 170 EFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHE--TDLLM 227 R + +S+K + EVL LQE L + D R++A ++ E L Sbjct: 1722 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1781 Query: 228 NTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279 ++EE ++Q+ G L L++ Q+ LL + +L Q+E L Sbjct: 1782 KAAILEE------KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1827 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 38.5 bits (88), Expect = 0.023 Identities = 53/249 (21%), Positives = 109/249 (43%), Gaps = 25/249 (10%) Query: 44 EAASNNETMATILLQNLLIQLDEQ----LGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPM 99 + AS + T+ N IQ +Q L + +KEK L L++ + QG H Sbjct: 499 QVASLTSELTTL---NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRH---- 551 Query: 100 HVAVVISNCLREERRILAAANMPVQGPLEKSLQ-SSSVSERQRNVEHKVAAIKNSVQMTE 158 V + S+ ++E+++ A + + Q +++ ER+ ++ + AA+K + + Sbjct: 552 QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEK 611 Query: 159 QDTKYLEDLQDEF----DYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALS 214 + LE LQ + + R ++ Q+ + A ++++V LQ + + ++ EA + Sbjct: 612 EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA 671 Query: 215 KMTQIIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESL-FQLR 273 ++ + + L E Q ++++A L L L+ + SL + R Sbjct: 672 QVAE--------LELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723 Query: 274 RQLEKLEEQ 282 R + LEEQ Sbjct: 724 RAADALEEQ 732 >gi|148612801 KIAA1009 protein [Homo sapiens] Length = 1403 Score = 38.5 bits (88), Expect = 0.023 Identities = 37/193 (19%), Positives = 92/193 (47%), Gaps = 20/193 (10%) Query: 63 QLDEQLGRVSKEKNLLLIHN---LKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAA 119 +L +L + EKN L + + + + ++ H+A + ++ RE ++L Sbjct: 1178 RLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC-- 1235 Query: 120 NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIK------NSVQMTEQDTKYLEDLQDEFDY 173 Q +E S SS V+E R + + I+ N +Q ++Q++ + ++++E Sbjct: 1236 ----QNAVENS--SSKVAELNRKIATQEVLIRHFQSQVNELQ-SKQESLVVSEVREEILQ 1288 Query: 174 RY--KTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTML 231 + K ++ + ++ +N + + L++ + ++ + + ++ QII +T ++ T Sbjct: 1289 KEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQ 1348 Query: 232 IEELQDWKRRQQI 244 +E++ WKR Q+ Sbjct: 1349 NKEVEKWKRLAQL 1361 Score = 30.8 bits (68), Expect = 4.8 Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 6/78 (7%) Query: 151 KNSVQMTEQDTKYLE-DLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEM-----LNS 204 KN+V+ E+ K LE DL+ + + K+++TM+Q + + ++ L QE LN Sbjct: 959 KNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQ 1018 Query: 205 LDFKRKEALSKMTQIIHE 222 D R +AL K I E Sbjct: 1019 HDSPRIKALEKELDDIKE 1036 >gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo sapiens] Length = 805 Score = 36.2 bits (82), Expect = 0.11 Identities = 50/240 (20%), Positives = 105/240 (43%), Gaps = 29/240 (12%) Query: 51 TMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLR 110 T+ + Q+L +Q+ E+ + +E + L+ I+K Q K ++ C + Sbjct: 520 TLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDK------ETQLI---CQK 570 Query: 111 EERRILAAANMPVQGPLEKSLQSS----SVSERQRNVEHKVAAIKNSVQMTEQDTKYLED 166 ++ + L +Q +E+ L+ + +Q E+ N Q E +K ++ Sbjct: 571 KKEKELVTTVQSLQQKVERCLEDGIRLPMLDAKQLQNEND-----NLRQQNETASKIIDS 625 Query: 167 LQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLL 226 QDE D IQ+M +++E LT Q+M+ L+ K++ + ++T+ + E Sbjct: 626 QQDEIDRMILEIQSM------QGKLSKEKLTTQKMMEELE-KKERNVQRLTKALLENQRQ 678 Query: 227 MN---TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQS 283 + ++L + + + RQQ PL + L + F ++ LF L+ L +++ Sbjct: 679 TDETCSLLDQGQEPDQSRQQTVLSKRPLFD-LTVIDQLFKEMSCCLFDLKALCSILNQRA 737 >gi|24307983 FtsJ methyltransferase domain containing 2 [Homo sapiens] Length = 835 Score = 35.8 bits (81), Expect = 0.15 Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 3/92 (3%) Query: 127 LEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQSDK 186 L SL S+S E +V H A S+ ++ +T+ + D FD +K ++ + Sbjct: 23 LALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSS 82 Query: 187 NSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQ 218 +M N Q+++ + F+ E L K +Q Sbjct: 83 RYSMYNS---VSQKLMAKMGFREGEGLGKYSQ 111 >gi|187761324 shootin1 isoform a [Homo sapiens] Length = 631 Score = 35.8 bits (81), Expect = 0.15 Identities = 73/392 (18%), Positives = 151/392 (38%), Gaps = 84/392 (21%) Query: 50 ETMATILLQNLLIQLDEQLGRVSKEKNLLLIH--NLK--------RIRKVLQGKFHGNPM 99 ET ++ Q + +L +Q+ V +EK +L I NLK + KV Q K Sbjct: 133 ETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEK------ 186 Query: 100 HVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQ 159 V+++ + E+R++L N +E+ + E ++++ K + + + + Sbjct: 187 ---TVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQN 243 Query: 160 DTKYLEDLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQI 219 K + S ++ Q + Q++L +LD +K+TQ Sbjct: 244 KLK-----------------------RQSHLLLQSSIPDQQLLKALDEN-----AKLTQQ 275 Query: 220 IHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279 + E + + + ++EL++ + LH + L+ LL E +L + + Sbjct: 276 LEE-ERIQHQQKVKELEEQLENET-------LHKEIHNLKQQLELLEEDKKELELKYQNS 327 Query: 280 EEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQ 339 EE++ + + D + + N +NS P P P P +++L+ Sbjct: 328 EEKARNLKHSVDELQKR------------VNQSENSVPPPPPPPPPLPPPPPNPIRSLMS 375 Query: 340 FTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEF 399 K P + K KA+ + + T++K ++EE + + Sbjct: 376 MIRKR----SHPSGSGAKKEKATQPETTEEV---------TDLKRQAVEEMMD--RIKKG 420 Query: 400 RHLQP--KEMKSSAGGKGNEGCHMVTEELHSI 429 HL+P + + + ++GC +EL I Sbjct: 421 VHLRPVNQTARPKTKPESSKGCESAVDELKGI 452 >gi|50511340 shootin1 isoform b [Homo sapiens] Length = 456 Score = 35.8 bits (81), Expect = 0.15 Identities = 73/392 (18%), Positives = 151/392 (38%), Gaps = 84/392 (21%) Query: 50 ETMATILLQNLLIQLDEQLGRVSKEKNLLLIH--NLK--------RIRKVLQGKFHGNPM 99 ET ++ Q + +L +Q+ V +EK +L I NLK + KV Q K Sbjct: 133 ETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEK------ 186 Query: 100 HVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQ 159 V+++ + E+R++L N +E+ + E ++++ K + + + + Sbjct: 187 ---TVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQN 243 Query: 160 DTKYLEDLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQI 219 K + S ++ Q + Q++L +LD +K+TQ Sbjct: 244 KLK-----------------------RQSHLLLQSSIPDQQLLKALDEN-----AKLTQQ 275 Query: 220 IHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279 + E + + + ++EL++ + LH + L+ LL E +L + + Sbjct: 276 LEE-ERIQHQQKVKELEEQLENET-------LHKEIHNLKQQLELLEEDKKELELKYQNS 327 Query: 280 EEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQ 339 EE++ + + D + + N +NS P P P P +++L+ Sbjct: 328 EEKARNLKHSVDELQKR------------VNQSENSVPPPPPPPPPLPPPPPNPIRSLMS 375 Query: 340 FTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEF 399 K P + K KA+ + + T++K ++EE + + Sbjct: 376 MIRKR----SHPSGSGAKKEKATQPETTEEV---------TDLKRQAVEEMMD--RIKKG 420 Query: 400 RHLQP--KEMKSSAGGKGNEGCHMVTEELHSI 429 HL+P + + + ++GC +EL I Sbjct: 421 VHLRPVNQTARPKTKPESSKGCESAVDELKGI 452 >gi|38570058 hypothetical protein LOC80129 [Homo sapiens] Length = 715 Score = 35.4 bits (80), Expect = 0.19 Identities = 39/207 (18%), Positives = 88/207 (42%), Gaps = 34/207 (16%) Query: 59 NLLIQLDEQLGRVSKE---KNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRI 115 ++++ EQL R+ +N + HNL+R K + + +H++++ + E Sbjct: 459 DVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEE-- 516 Query: 116 LAAANMPVQGPLEKSLQSSSVSERQ------RNVEHKVAAIKNSVQ-MTEQDTKYLEDLQ 168 EK +++ V ER RN++ KV ++ + + T+ L Sbjct: 517 ------------EKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLA 564 Query: 169 DEFDYRYKTIQ----------TMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQ 218 D + + KT++ + DQ +K +++++++ L++ + + KE + Sbjct: 565 DTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARN 624 Query: 219 IIHETDLLMNTMLIEELQDWKRRQQIA 245 +I M T+ + KR +Q+A Sbjct: 625 MIEVVTSEMKTLKKSLEEAEKREKQLA 651 >gi|7705415 hook homolog 1 [Homo sapiens] Length = 728 Score = 35.4 bits (80), Expect = 0.19 Identities = 32/128 (25%), Positives = 63/128 (49%), Gaps = 19/128 (14%) Query: 176 KTIQTMDQSDKNSAMVNQEVLTLQEMLNS--------LDFKRKEALSKMTQIIHETDLLM 227 + I T+++S ++ M + L +E+L+S L+ + K AL ++ + + E + L Sbjct: 139 QNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELR 198 Query: 228 NT-----MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCF----TLLAESLFQLRRQLEK 278 M + LQD K + ++ LDQL F T++A+ F + QLE+ Sbjct: 199 QRCEELDMQVTTLQDEKN--SLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQ 256 Query: 279 LEEQSTKM 286 L+E++ ++ Sbjct: 257 LQEENFRL 264 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.133 0.388 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,865,364 Number of Sequences: 37866 Number of extensions: 1232747 Number of successful extensions: 4021 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 15 Number of HSP's successfully gapped in prelim test: 95 Number of HSP's that attempted gapping in prelim test: 3851 Number of HSP's gapped (non-prelim): 217 length of query: 748 length of database: 18,247,518 effective HSP length: 110 effective length of query: 638 effective length of database: 14,082,258 effective search space: 8984480604 effective search space used: 8984480604 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.