Guide to the Human Genome
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Search of human proteins with 4507255

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507255 signal transducer and activator of transcription 4
[Homo sapiens]
         (748 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507255 signal transducer and activator of transcription 4 [H...  1500   0.0  
gi|6274552 signal transducer and activator of transcription 1 is...   757   0.0  
gi|21536301 signal transducer and activator of transcription 1 i...   749   0.0  
gi|21618338 signal transducer and activator of transcription 3 i...   696   0.0  
gi|21618340 signal transducer and activator of transcription 3 i...   696   0.0  
gi|47458820 signal transducer and activator of transcription 3 i...   692   0.0  
gi|4885615 signal transducer and activator of transcription 2 [H...   510   e-144
gi|21618344 signal transducer and activator of transcription 5B ...   310   3e-84
gi|21618342 signal transducer and activator of transcription 5A ...   291   2e-78
gi|23397678 signal transducer and activator of transcription 6 [...   207   2e-53
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa...    44   5e-04
gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap...    44   5e-04
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    42   0.002
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    42   0.002
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    42   0.002
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    42   0.002
gi|212276078 leucine rich repeat (in FLII) interacting protein 1...    41   0.004
gi|126362969 Nck-associated protein 5 isoform 2 [Homo sapiens]         39   0.013
gi|126362967 Nck-associated protein 5 isoform 1 [Homo sapiens]         39   0.013
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           39   0.013
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           39   0.013
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           39   0.013
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         39   0.023
gi|148612801 KIAA1009 protein [Homo sapiens]                           39   0.023
gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo...    36   0.11 
gi|24307983 FtsJ methyltransferase domain containing 2 [Homo sap...    36   0.15 
gi|187761324 shootin1 isoform a [Homo sapiens]                         36   0.15 
gi|50511340 shootin1 isoform b [Homo sapiens]                          36   0.15 
gi|38570058 hypothetical protein LOC80129 [Homo sapiens]               35   0.19 
gi|7705415 hook homolog 1 [Homo sapiens]                               35   0.19 

>gi|4507255 signal transducer and activator of transcription 4 [Homo
           sapiens]
          Length = 748

 Score = 1500 bits (3883), Expect = 0.0
 Identities = 748/748 (100%), Positives = 748/748 (100%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60
           MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL
Sbjct: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60

Query: 61  LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120
           LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN
Sbjct: 61  LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120

Query: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180
           MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT
Sbjct: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180

Query: 181 MDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKR 240
           MDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKR
Sbjct: 181 MDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKR 240

Query: 241 RQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHM 300
           RQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHM
Sbjct: 241 RQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHM 300

Query: 301 LERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVK 360
           LERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVK
Sbjct: 301 LERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVK 360

Query: 361 ASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCH 420
           ASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCH
Sbjct: 361 ASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCH 420

Query: 421 MVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNL 480
           MVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNL
Sbjct: 421 MVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNL 480

Query: 481 VFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCK 540
           VFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCK
Sbjct: 481 VFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCK 540

Query: 541 EHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFS 600
           EHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFS
Sbjct: 541 EHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFS 600

Query: 601 ESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKY 660
           ESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKY
Sbjct: 601 ESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKY 660

Query: 661 LYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPM 720
           LYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPM
Sbjct: 661 LYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPM 720

Query: 721 SPSVYAVLRENLSPTTIETAMKSPYSAE 748
           SPSVYAVLRENLSPTTIETAMKSPYSAE
Sbjct: 721 SPSVYAVLRENLSPTTIETAMKSPYSAE 748


>gi|6274552 signal transducer and activator of transcription 1
           isoform alpha [Homo sapiens]
          Length = 750

 Score =  757 bits (1954), Expect = 0.0
 Identities = 398/736 (54%), Positives = 527/736 (71%), Gaps = 16/736 (2%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60
           MSQW ++QQL+ KFLEQV Q YDD+FPMEIR  LAQW+E QDWE A+N+ + ATI   +L
Sbjct: 1   MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60

Query: 61  LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120
           L QLD+Q  R S E N LL HN+++ ++ LQ  F  +P+ ++++I +CL+EER+IL  A 
Sbjct: 61  LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120

Query: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180
              Q     ++QS+ + ++Q+ ++ KV  +K+ V   E + K LEDLQDE+D++ KT+Q 
Sbjct: 121 RFNQAQ-SGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQN 179

Query: 181 MDQSDKNSAMVNQ--EVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDW 238
            +      A  +Q  E L L++M   LD KRKE + K+ ++++ T+L  N ++ +EL +W
Sbjct: 180 REHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEW 239

Query: 239 KRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRT 298
           KRRQQ ACIGGP +  LDQLQN FT++AESL Q+R+QL+KLEE   K TYE DPI   + 
Sbjct: 240 KRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQ 299

Query: 299 HMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVK 358
            + +R   L   L ++SFVVERQPCMPTHPQRPLVLKT +QFTVKLRLL+KL ELNY +K
Sbjct: 300 VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLK 359

Query: 359 VKASIDKNVSTLSN----RRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGK 414
           VK   DK+V+  +     R+F + GT+ K M++EES+NGSL+ EFRHLQ KE K+ AG +
Sbjct: 360 VKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKN-AGTR 418

Query: 415 GNEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVST 474
            NEG  +VTEELHS++FETQ+C  GL IDLET+SLPVV+ISNVSQLP+ WASI+WYN+  
Sbjct: 419 TNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLV 478

Query: 475 NDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLT 534
            + +NL FF  PP A  +QL EV+SWQFSS   RGLN DQL+ML EKL   ++  DG + 
Sbjct: 479 AEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIP 538

Query: 535 WAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGT 594
           W +FCKE++  K+F FW W+E+IL+LIKKH+LPLW DG +MGF+SKE+ER LLKD+ PGT
Sbjct: 539 WTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGT 598

Query: 595 FLLRFSE-SHLGGITFTWVDHSES-GEVRFHSVEPYNKGRLSALPFADILRDYKVIMAEN 652
           FLLRFSE S  G ITFTWV+ S++ GE  FH+VEPY K  LSA+ F DI+R+YKV+ AEN
Sbjct: 599 FLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAEN 658

Query: 653 IPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTE-RGDK--GYVPSVFIPISTIRSDST 709
           IPENPLKYLYP+I KD AFGK+Y S+P E   P E  G K  GY+ +  I +S +     
Sbjct: 659 IPENPLKYLYPNIDKDHAFGKYY-SRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRL 717

Query: 710 EPHSPSDLLPMSPSVY 725
           +  +  +LLPMSP  +
Sbjct: 718 Q--TTDNLLPMSPEEF 731


>gi|21536301 signal transducer and activator of transcription 1
           isoform beta [Homo sapiens]
          Length = 712

 Score =  749 bits (1935), Expect = 0.0
 Identities = 392/715 (54%), Positives = 517/715 (72%), Gaps = 14/715 (1%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60
           MSQW ++QQL+ KFLEQV Q YDD+FPMEIR  LAQW+E QDWE A+N+ + ATI   +L
Sbjct: 1   MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60

Query: 61  LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120
           L QLD+Q  R S E N LL HN+++ ++ LQ  F  +P+ ++++I +CL+EER+IL  A 
Sbjct: 61  LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120

Query: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180
              Q     ++QS+ + ++Q+ ++ KV  +K+ V   E + K LEDLQDE+D++ KT+Q 
Sbjct: 121 RFNQAQ-SGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQN 179

Query: 181 MDQSDKNSAMVNQ--EVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDW 238
            +      A  +Q  E L L++M   LD KRKE + K+ ++++ T+L  N ++ +EL +W
Sbjct: 180 REHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEW 239

Query: 239 KRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRT 298
           KRRQQ ACIGGP +  LDQLQN FT++AESL Q+R+QL+KLEE   K TYE DPI   + 
Sbjct: 240 KRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQ 299

Query: 299 HMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVK 358
            + +R   L   L ++SFVVERQPCMPTHPQRPLVLKT +QFTVKLRLL+KL ELNY +K
Sbjct: 300 VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLK 359

Query: 359 VKASIDKNVSTLSN----RRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGK 414
           VK   DK+V+  +     R+F + GT+ K M++EES+NGSL+ EFRHLQ KE K+ AG +
Sbjct: 360 VKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKN-AGTR 418

Query: 415 GNEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVST 474
            NEG  +VTEELHS++FETQ+C  GL IDLET+SLPVV+ISNVSQLP+ WASI+WYN+  
Sbjct: 419 TNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLV 478

Query: 475 NDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLT 534
            + +NL FF  PP A  +QL EV+SWQFSS   RGLN DQL+ML EKL   ++  DG + 
Sbjct: 479 AEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIP 538

Query: 535 WAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGT 594
           W +FCKE++  K+F FW W+E+IL+LIKKH+LPLW DG +MGF+SKE+ER LLKD+ PGT
Sbjct: 539 WTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGT 598

Query: 595 FLLRFSE-SHLGGITFTWVDHSES-GEVRFHSVEPYNKGRLSALPFADILRDYKVIMAEN 652
           FLLRFSE S  G ITFTWV+ S++ GE  FH+VEPY K  LSA+ F DI+R+YKV+ AEN
Sbjct: 599 FLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAEN 658

Query: 653 IPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTE-RGDK--GYVPSVFIPISTI 704
           IPENPLKYLYP+I KD AFGK+Y S+P E   P E  G K  GY+ +  I +S +
Sbjct: 659 IPENPLKYLYPNIDKDHAFGKYY-SRPKEAPEPMELDGPKGTGYIKTELISVSEV 712


>gi|21618338 signal transducer and activator of transcription 3
           isoform 2 [Homo sapiens]
          Length = 769

 Score =  696 bits (1795), Expect = 0.0
 Identities = 357/734 (48%), Positives = 502/734 (68%), Gaps = 19/734 (2%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60
           M+QWNQ+QQL+ ++LEQ+ Q Y D+FPME+R  LA WIE+QDW  A++ E+ AT++  NL
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60

Query: 61  LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL-AAA 119
           L ++D+Q  R  +E N+L  HNL+RI++ LQ ++   PM +A +++ CL EE R+L  AA
Sbjct: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120

Query: 120 NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQ 179
               QG       ++ V+E+Q+ +E  +  ++  VQ  EQ  K +E+LQD+FD+ YKT++
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180

Query: 180 TM----DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235
           +     D +  N ++  Q++  L++ML +LD  R+  +S++  ++   + +  T+  EEL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240

Query: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295
            DWKRRQQIACIGGP +  LD+L+N  T LAES  Q R+Q++KLEE   K++Y+GDPI  
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300

Query: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355
            R  + ER+  L  NL K++FVVERQPCMP HP RPLV+KT +QFT K+RLL+K PELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360

Query: 356 QVKVKASIDKNVSTLS----NRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSA 411
           Q+K+K  IDK+   ++    +R+F + GTN K M++EES+NGSLS EF+HL  +E +   
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420

Query: 412 GGKGN-EGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWY 470
           GG+ N +   +VTEELH ITFET++   GL IDLET SLPVV+ISN+ Q+PNAWASI+WY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480

Query: 471 NVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQS-SYS 529
           N+ TN+ +N+ FF  PP  T  Q+ EV+SWQFSS   RGL+ +QL  LAEKL     +YS
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540

Query: 530 DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKD 589
              +TWAKFCKE++ GK F+FW WL+ I+DL+KK+IL LW +GY+MGF+SKE+ER +L  
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600

Query: 590 KMPGTFLLRFSESHL-GGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVI 648
           K PGTFLLRFSES   GG+TFTWV+   SG+ +  SVEPY K +L+ + FA+I+  YK++
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660

Query: 649 MAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDS 708
            A NI  +PL YLYPDIPK++AFGK Y     +     + G   Y+ + FI ++     +
Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGK-YCRPESQEHPEADPGAAPYLKTKFICVTPTTCSN 719

Query: 709 TEPHSPSDLLPMSP 722
           T        LPMSP
Sbjct: 720 TID------LPMSP 727


>gi|21618340 signal transducer and activator of transcription 3
           isoform 1 [Homo sapiens]
          Length = 770

 Score =  696 bits (1795), Expect = 0.0
 Identities = 356/734 (48%), Positives = 501/734 (68%), Gaps = 18/734 (2%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60
           M+QWNQ+QQL+ ++LEQ+ Q Y D+FPME+R  LA WIE+QDW  A++ E+ AT++  NL
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60

Query: 61  LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL-AAA 119
           L ++D+Q  R  +E N+L  HNL+RI++ LQ ++   PM +A +++ CL EE R+L  AA
Sbjct: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120

Query: 120 NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQ 179
               QG       ++ V+E+Q+ +E  +  ++  VQ  EQ  K +E+LQD+FD+ YKT++
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180

Query: 180 TM----DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235
           +     D +  N ++  Q++  L++ML +LD  R+  +S++  ++   + +  T+  EEL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240

Query: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295
            DWKRRQQIACIGGP +  LD+L+N  T LAES  Q R+Q++KLEE   K++Y+GDPI  
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300

Query: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355
            R  + ER+  L  NL K++FVVERQPCMP HP RPLV+KT +QFT K+RLL+K PELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360

Query: 356 QVKVKASIDKNVSTLS----NRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSA 411
           Q+K+K  IDK+   ++    +R+F + GTN K M++EES+NGSLS EF+HL  +E +   
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420

Query: 412 GGKGN-EGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWY 470
           GG+ N +   +VTEELH ITFET++   GL IDLET SLPVV+ISN+ Q+PNAWASI+WY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480

Query: 471 NVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQS-SYS 529
           N+ TN+ +N+ FF  PP  T  Q+ EV+SWQFSS   RGL+ +QL  LAEKL     +YS
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540

Query: 530 DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKD 589
              +TWAKFCKE++ GK F+FW WL+ I+DL+KK+IL LW +GY+MGF+SKE+ER +L  
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600

Query: 590 KMPGTFLLRFSESHL-GGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVI 648
           K PGTFLLRFSES   GG+TFTWV+   SG+ +  SVEPY K +L+ + FA+I+  YK++
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660

Query: 649 MAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDS 708
            A NI  +PL YLYPDIPK++AFGK+   +  E           Y+ + FI ++     +
Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN 720

Query: 709 TEPHSPSDLLPMSP 722
           T        LPMSP
Sbjct: 721 TID------LPMSP 728


>gi|47458820 signal transducer and activator of transcription 3
           isoform 3 [Homo sapiens]
          Length = 722

 Score =  692 bits (1787), Expect = 0.0
 Identities = 350/714 (49%), Positives = 494/714 (69%), Gaps = 12/714 (1%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60
           M+QWNQ+QQL+ ++LEQ+ Q Y D+FPME+R  LA WIE+QDW  A++ E+ AT++  NL
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60

Query: 61  LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL-AAA 119
           L ++D+Q  R  +E N+L  HNL+RI++ LQ ++   PM +A +++ CL EE R+L  AA
Sbjct: 61  LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120

Query: 120 NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQ 179
               QG       ++ V+E+Q+ +E  +  ++  VQ  EQ  K +E+LQD+FD+ YKT++
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180

Query: 180 TM----DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235
           +     D +  N ++  Q++  L++ML +LD  R+  +S++  ++   + +  T+  EEL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240

Query: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295
            DWKRRQQIACIGGP +  LD+L+N  T LAES  Q R+Q++KLEE   K++Y+GDPI  
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300

Query: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355
            R  + ER+  L  NL K++FVVERQPCMP HP RPLV+KT +QFT K+RLL+K PELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360

Query: 356 QVKVKASIDKNVSTLS----NRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSA 411
           Q+K+K  IDK+   ++    +R+F + GTN K M++EES+NGSLS EF+HL  +E +   
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420

Query: 412 GGKGN-EGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWY 470
           GG+ N +   +VTEELH ITFET++   GL IDLET SLPVV+ISN+ Q+PNAWASI+WY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480

Query: 471 NVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQS-SYS 529
           N+ TN+ +N+ FF  PP  T  Q+ EV+SWQFSS   RGL+ +QL  LAEKL     +YS
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540

Query: 530 DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKD 589
              +TWAKFCKE++ GK F+FW WL+ I+DL+KK+IL LW +GY+MGF+SKE+ER +L  
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600

Query: 590 KMPGTFLLRFSESHL-GGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVI 648
           K PGTFLLRFSES   GG+TFTWV+   SG+ +  SVEPY K +L+ + FA+I+  YK++
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM 660

Query: 649 MAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPIS 702
            A NI  +PL YLYPDIPK++AFGK+   +  E           Y+ + FI ++
Sbjct: 661 DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVT 714


>gi|4885615 signal transducer and activator of transcription 2 [Homo
           sapiens]
          Length = 851

 Score =  510 bits (1313), Expect = e-144
 Identities = 290/685 (42%), Positives = 427/685 (62%), Gaps = 11/685 (1%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNF-PMEIRHLLAQWIENQDWEAAS--NNETMATILL 57
           M+QW  +Q L+  F +Q+ Q Y  +  P++IR  LA WIE+Q+W+ A+  ++++ AT+L 
Sbjct: 1   MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLF 60

Query: 58  QNLLIQLDEQLGRVSKE-KNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116
            + L QL+ + GR S++ ++LLL HNL++  + +Q  F  +P  +A +I N L EE+RIL
Sbjct: 61  FHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQ-PFSQDPTQLAEMIFNLLLEEKRIL 119

Query: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176
             A        E  L++  V  +Q  +E ++  ++  ++   +    L+D QD F +RYK
Sbjct: 120 IQAQRAQLEQGEPVLETP-VESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYK 178

Query: 177 TIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQ 236
            IQ   ++        +E   LQE LN LD +RKE L     ++     L+  +L+ +L+
Sbjct: 179 -IQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIE-LLLPKLE 236

Query: 237 DWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQ 296
           +WK +QQ ACI  P+ +GL+QL+  FT  A+ LF LR+ L++L+  S  ++Y+ DP+   
Sbjct: 237 EWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLTKG 296

Query: 297 RTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQ 356
                 +VT L+  L   +FVVE QPCMP  P RPL+LKT  +FTV+ RLL++L E N  
Sbjct: 297 VDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNES 356

Query: 357 VKVKASIDKNVSTLSN-RRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKG 415
           + V+ SID+N   L   R+F +  +N K ++ E+  +  L  +F +L   E +S   GKG
Sbjct: 357 LTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKG 416

Query: 416 -NEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVST 474
            N+G   VTEELH I+F  +    GL  +L+T +LPVV+ISN++QL  AWAS++W+N+ +
Sbjct: 417 SNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLS 476

Query: 475 NDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYS-DGHL 533
            + QN  FF+NPP A  S L   +SWQFSSYVGRGLNSDQL ML  KL  Q+  + D  L
Sbjct: 477 PNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLL 536

Query: 534 TWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPG 593
           +WA F K   P     FWTWL+ IL+L+  H+  LW DG +MGFVS+ +ER LLK  M G
Sbjct: 537 SWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSG 596

Query: 594 TFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENI 653
           TFLLRFSES  GGIT +WV+H +  +V  +SV+PY K  L +LP  +I+R Y+++  ENI
Sbjct: 597 TFLLRFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENI 656

Query: 654 PENPLKYLYPDIPKDKAFGKHYSSQ 678
           PENPL++LYP IP+D+AFG +Y  +
Sbjct: 657 PENPLRFLYPRIPRDEAFGCYYQEK 681


>gi|21618344 signal transducer and activator of transcription 5B
           [Homo sapiens]
          Length = 787

 Score =  310 bits (794), Expect = 3e-84
 Identities = 229/732 (31%), Positives = 362/732 (49%), Gaps = 70/732 (9%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAAS----NNETMATIL 56
           M+ W Q QQL+ + L Q+   Y  +FP+E+RH L+QWIE+Q W++           AT L
Sbjct: 1   MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL 60

Query: 57  LQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116
           L+ L+ +L ++      E   LL   L      LQ  +   PM +   I + L  E+R++
Sbjct: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120

Query: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176
             AN    G       + ++S++   +      ++   Q TE + K L+  Q+ F  +Y+
Sbjct: 121 REAN---NGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQ 177

Query: 177 T-------------IQTMDQSDKNSAMVNQEVLT---LQEMLNSLDFKRKEALSKMTQII 220
                         +   ++  + +A+  ++V     LQ    +L   R E   K  + +
Sbjct: 178 ESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTL 237

Query: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280
                    +L +EL  WKRRQQ+A  GGP    LD LQ+    LAE ++Q R+Q+ + E
Sbjct: 238 QLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAE 297

Query: 281 EQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQF 340
               ++   G P+      +   +T +I  L  ++F++E+QP        P VLKT  +F
Sbjct: 298 HLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKF 348

Query: 341 TVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLSNRRFVLCGTNVKAMSIEE--SS 391
              +RLL+  KL       +VKA+I      K++    N R    G  +    + E   +
Sbjct: 349 AATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQA 408

Query: 392 NGSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSL 449
            G+LS  FR++  K +K S       G   VTEE  +I FE+Q  + G  L   ++T SL
Sbjct: 409 TGTLSAHFRNMSLKRIKRS----DRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSL 464

Query: 450 PVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--G 507
           PVV+I + SQ  NA A+++W N      +  V F  P      QL E ++ +F + V   
Sbjct: 465 PVVVIVHGSQDNNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSN 522

Query: 508 RGLNSDQLHMLAEKLTVQSS-----YSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIK 562
           RGL  + L  LA+KL   SS     YS   ++W++F +E+LPG+++TFW W + +++++K
Sbjct: 523 RGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLK 582

Query: 563 KHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRF 622
           KH+ P W DG ++GFV+K++   LL +K  GTFLLRFS+S +GGIT  W    +S E  F
Sbjct: 583 KHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSQERMF 640

Query: 623 HSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEV 682
            ++ P+     S    AD L D           N L Y++PD PKD+ + K+Y+  PCE 
Sbjct: 641 WNLMPFTTRDFSIRSLADRLGDL----------NYLIYVFPDRPKDEVYSKYYTPVPCES 690

Query: 683 SRPTERGDKGYV 694
           +  T +   GYV
Sbjct: 691 A--TAKAVDGYV 700


>gi|21618342 signal transducer and activator of transcription 5A
           [Homo sapiens]
          Length = 794

 Score =  291 bits (744), Expect = 2e-78
 Identities = 218/714 (30%), Positives = 350/714 (49%), Gaps = 68/714 (9%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAAS----NNETMATIL 56
           M+ W Q QQL+   L Q+   Y  +FP+E+RH LAQWIE+Q W+A       +   AT L
Sbjct: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60

Query: 57  LQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116
           L+ L+ +L ++      E   LL   L      LQ  +   P+ +   I + L  E+R++
Sbjct: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120

Query: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176
             AN     P    +   ++S++   +      ++   Q TE + K L+  Q+ F  +Y+
Sbjct: 121 REANN-CSSPA--GILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQ 177

Query: 177 T-------------IQTMDQSDKNSAMVNQEVLT---LQEMLNSLDFKRKEALSKMTQII 220
                         +   ++  + +A+  ++V     LQ    +L   R E   K  + +
Sbjct: 178 ESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTL 237

Query: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280
                    +L +EL  WKRRQQ+A  GGP    LD LQ+    LAE ++Q R+Q+ + E
Sbjct: 238 QLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAE 297

Query: 281 EQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQF 340
               ++   G P+      +   +T +I  L  ++F++E+QP        P VLKT  +F
Sbjct: 298 HLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKF 348

Query: 341 TVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLSNRRFVLCGTNVKAMSIEE--SS 391
              +RLL+  KL       +VKA+I      K++    N R    G  +    + E   +
Sbjct: 349 AATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQA 408

Query: 392 NGSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSL 449
            G+LS  FR++  K +K +       G   VTEE  ++ FE+Q  +    L   ++T SL
Sbjct: 409 TGTLSAHFRNMSLKRIKRA----DRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSL 464

Query: 450 PVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--G 507
           PVV+I + SQ  NA A+++W N      +  V F  P      QL E ++ +F + V   
Sbjct: 465 PVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSN 522

Query: 508 RGLNSDQLHMLAEKLTVQSS-----YSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIK 562
           RGL  + L  LA+KL   SS     YS   ++W++F +E+LPG ++TFW W + +++++K
Sbjct: 523 RGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLK 582

Query: 563 KHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRF 622
           KH  P W DG ++GFV+K++   LL +K  GTFLLRFS+S +GGIT  W    +S E   
Sbjct: 583 KHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPERNL 640

Query: 623 HSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYS 676
            +++P+     S    AD L D   ++          Y++PD PKD+ F K+Y+
Sbjct: 641 WNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRPKDEVFSKYYT 684


>gi|23397678 signal transducer and activator of transcription 6
           [Homo sapiens]
          Length = 847

 Score =  207 bits (528), Expect = 2e-53
 Identities = 203/756 (26%), Positives = 328/756 (43%), Gaps = 120/756 (15%)

Query: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNET----MATIL 56
           MS W  V ++     E+V + Y D FP  +RHLL  W+E+Q WE    ++     +A+ L
Sbjct: 1   MSLWGLVSKMPP---EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56

Query: 57  LQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116
           L + +  L   +G   +   +L      +    L+  +  +P+ +       L+ E++ +
Sbjct: 57  LSDTVQHLQASVGEQGEGSTIL------QHISTLESIYQRDPLKLVATFRQILQGEKKAV 110

Query: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176
                 +  P     +        R ++H+V  I              E LQ   +    
Sbjct: 111 MEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIH----------LLREALQKGAEAGQV 160

Query: 177 TIQTMDQSDKNSAMVNQEV-LTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235
           ++ ++ ++  N    ++ + + LQE    L+  +                    ++++ +
Sbjct: 161 SLHSLIETPANGTGPSEALAMLLQETTGELEAAK-------------------ALVLKRI 201

Query: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295
           Q WKR+QQ+A  G P    L  LQ       ESL  +  QL     Q       G+  P 
Sbjct: 202 QIWKRQQQLAGNGAPFEESLAPLQE----RCESLVDIYSQL-----QQEVGAAGGELEPK 252

Query: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355
            R  +  R+  ++  L  + F+VE+QP        P VLKT  +F   +R L+ L  L  
Sbjct: 253 TRASLTGRLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGLRFLGA 304

Query: 356 QVK---VKASI--DKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVE-----------F 399
             K   V+A +  +K    LS    V  G    A S  E  N ++ +E           F
Sbjct: 305 PAKPPLVRADMVTEKQARELS----VPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF 360

Query: 400 RHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSLPVVMISNV 457
           ++L  K++K        +G   VTEE  ++ F     L    L I L+  SLP+V+I + 
Sbjct: 361 KNLLLKKIKRCE----RKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHG 416

Query: 458 SQLPNAWASIIWYNV-STNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVG--RGLNSDQ 514
           +Q  NA A+I+W N  S  D    V     P     ++ E ++ +F + VG  RGL  + 
Sbjct: 417 NQDNNAKATILWDNAFSEMDRVPFVVAERVP---WEKMCETLNLKFMAEVGTNRGLLPEH 473

Query: 515 LHMLAEKLTVQSSYS-----DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLW 569
              LA+K+   +S S        ++W++F KE L G+ FTFW W + +LDL K+ +   W
Sbjct: 474 FLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYW 533

Query: 570 IDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYN 629
            D  ++GF+SK+    LL ++  GTFLLRFS+S +GGIT   V   + G  +  +++P++
Sbjct: 534 SDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFS 593

Query: 630 KGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERG 689
              LS     D +RD             LK LYP  PKD+AF  HY        +P + G
Sbjct: 594 AKDLSIRSLGDRIRDLA----------QLKNLYPKKPKDEAFRSHY--------KPEQMG 635

Query: 690 --DKGYVPSVFIPISTIRSDSTEPHSPSDLLPMSPS 723
              +GYVP+      T+  D   P     +  M PS
Sbjct: 636 KDGRGYVPATI--KMTVERDQPLPTPELQMPTMVPS 669


>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
           sapiens]
          Length = 1185

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 59/258 (22%), Positives = 98/258 (37%), Gaps = 16/258 (6%)

Query: 56  LLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCL--REER 113
           L + L   L ++   ++KE N+     L+R  ++ + K   N   + +    CL  R ER
Sbjct: 78  LQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHER 137

Query: 114 RI-LAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFD 172
            + +       Q P   S +   +   +   EH  A  +   +      +    L++E  
Sbjct: 138 SLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELG 197

Query: 173 YRYKTIQTMDQSDKNSAMVNQEVLTL---QEMLNSLDFKRKEALSKMTQIIHETDLLMNT 229
             +K +  + + +     +   VL +   QE   S   KR    S    + HE DL    
Sbjct: 198 ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKR----SSDGSLSHEEDLAKVI 253

Query: 230 MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYE 289
            L E +    R Q        +   L  L +  T L E L   R+ L K EE +TK+  +
Sbjct: 254 ELQEIISKQSREQS------QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRD 307

Query: 290 GDPIPMQRTHMLERVTFL 307
                 Q+  M ER+T L
Sbjct: 308 VREAMAQKEDMEERITTL 325


>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo
           sapiens]
          Length = 1202

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 59/258 (22%), Positives = 98/258 (37%), Gaps = 16/258 (6%)

Query: 56  LLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCL--REER 113
           L + L   L ++   ++KE N+     L+R  ++ + K   N   + +    CL  R ER
Sbjct: 78  LQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHER 137

Query: 114 RI-LAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFD 172
            + +       Q P   S +   +   +   EH  A  +   +      +    L++E  
Sbjct: 138 SLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELG 197

Query: 173 YRYKTIQTMDQSDKNSAMVNQEVLTL---QEMLNSLDFKRKEALSKMTQIIHETDLLMNT 229
             +K +  + + +     +   VL +   QE   S   KR    S    + HE DL    
Sbjct: 198 ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKR----SSDGSLSHEEDLAKVI 253

Query: 230 MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYE 289
            L E +    R Q        +   L  L +  T L E L   R+ L K EE +TK+  +
Sbjct: 254 ELQEIISKQSREQS------QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRD 307

Query: 290 GDPIPMQRTHMLERVTFL 307
                 Q+  M ER+T L
Sbjct: 308 VREAMAQKEDMEERITTL 325


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/174 (22%), Positives = 82/174 (47%), Gaps = 11/174 (6%)

Query: 110  REERRILAAANMPVQGPLEK-SLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQ 168
            R++R + AAA   ++G L+   LQ+ S       ++ +  AIK   ++  Q   +  +L+
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSA------IKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 169  DEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMN 228
            D    R +   T  +++K +  +  +++ LQE L + +  RK+A  +  ++  E  L  +
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE--LASS 1720

Query: 229  TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQ 282
                  LQD KRR +       L   L++ Q     +++ + +  +Q E+L  +
Sbjct: 1721 LSGRNALQDEKRRLEARI--AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 47/264 (17%), Positives = 105/264 (39%), Gaps = 39/264 (14%)

Query: 58   QNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILA 117
            +N L +L+++  ++++EKNLL        ++ LQ +     ++          EE R+  
Sbjct: 872  ENELKELEQKHSQLTEEKNLL--------QEQLQAE---TELYAEA-------EEMRVRL 913

Query: 118  AANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKT 177
            AA       +   +++    E  R  + +    K + QM + +    E L++E   R K 
Sbjct: 914  AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE----EQLEEEEAARQKL 969

Query: 178  IQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRK-----------------EALSKMTQII 220
                  ++     +  E+L + +  N L  +RK                 E    +T++ 
Sbjct: 970  QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 221  HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280
            ++ + +++ + +   ++ K RQ++  +   L             L   + +L+ QL K E
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 281  EQSTKMTYEGDPIPMQRTHMLERV 304
            E+        D    Q+ + L+++
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKI 1113


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/174 (22%), Positives = 82/174 (47%), Gaps = 11/174 (6%)

Query: 110  REERRILAAANMPVQGPLEK-SLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQ 168
            R++R + AAA   ++G L+   LQ+ S       ++ +  AIK   ++  Q   +  +L+
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSA------IKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 169  DEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMN 228
            D    R +   T  +++K +  +  +++ LQE L + +  RK+A  +  ++  E  L  +
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE--LASS 1727

Query: 229  TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQ 282
                  LQD KRR +       L   L++ Q     +++ + +  +Q E+L  +
Sbjct: 1728 LSGRNALQDEKRRLEARI--AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 47/264 (17%), Positives = 105/264 (39%), Gaps = 39/264 (14%)

Query: 58   QNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILA 117
            +N L +L+++  ++++EKNLL        ++ LQ +     ++          EE R+  
Sbjct: 879  ENELKELEQKHSQLTEEKNLL--------QEQLQAE---TELYAEA-------EEMRVRL 920

Query: 118  AANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKT 177
            AA       +   +++    E  R  + +    K + QM + +    E L++E   R K 
Sbjct: 921  AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE----EQLEEEEAARQKL 976

Query: 178  IQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRK-----------------EALSKMTQII 220
                  ++     +  E+L + +  N L  +RK                 E    +T++ 
Sbjct: 977  QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 221  HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280
            ++ + +++ + +   ++ K RQ++  +   L             L   + +L+ QL K E
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 281  EQSTKMTYEGDPIPMQRTHMLERV 304
            E+        D    Q+ + L+++
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKI 1120


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/174 (22%), Positives = 82/174 (47%), Gaps = 11/174 (6%)

Query: 110  REERRILAAANMPVQGPLEK-SLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQ 168
            R++R + AAA   ++G L+   LQ+ S       ++ +  AIK   ++  Q   +  +L+
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSA------IKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 169  DEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMN 228
            D    R +   T  +++K +  +  +++ LQE L + +  RK+A  +  ++  E  L  +
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE--LASS 1727

Query: 229  TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQ 282
                  LQD KRR +       L   L++ Q     +++ + +  +Q E+L  +
Sbjct: 1728 LSGRNALQDEKRRLEARI--AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 47/264 (17%), Positives = 105/264 (39%), Gaps = 39/264 (14%)

Query: 58   QNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILA 117
            +N L +L+++  ++++EKNLL        ++ LQ +     ++          EE R+  
Sbjct: 879  ENELKELEQKHSQLTEEKNLL--------QEQLQAE---TELYAEA-------EEMRVRL 920

Query: 118  AANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKT 177
            AA       +   +++    E  R  + +    K + QM + +    E L++E   R K 
Sbjct: 921  AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE----EQLEEEEAARQKL 976

Query: 178  IQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRK-----------------EALSKMTQII 220
                  ++     +  E+L + +  N L  +RK                 E    +T++ 
Sbjct: 977  QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 221  HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280
            ++ + +++ + +   ++ K RQ++  +   L             L   + +L+ QL K E
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 281  EQSTKMTYEGDPIPMQRTHMLERV 304
            E+        D    Q+ + L+++
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKI 1120


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/174 (22%), Positives = 82/174 (47%), Gaps = 11/174 (6%)

Query: 110  REERRILAAANMPVQGPLEK-SLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQ 168
            R++R + AAA   ++G L+   LQ+ S       ++ +  AIK   ++  Q   +  +L+
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSA------IKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 169  DEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMN 228
            D    R +   T  +++K +  +  +++ LQE L + +  RK+A  +  ++  E  L  +
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE--LASS 1720

Query: 229  TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQ 282
                  LQD KRR +       L   L++ Q     +++ + +  +Q E+L  +
Sbjct: 1721 LSGRNALQDEKRRLEARI--AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 47/264 (17%), Positives = 105/264 (39%), Gaps = 39/264 (14%)

Query: 58   QNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILA 117
            +N L +L+++  ++++EKNLL        ++ LQ +     ++          EE R+  
Sbjct: 872  ENELKELEQKHSQLTEEKNLL--------QEQLQAE---TELYAEA-------EEMRVRL 913

Query: 118  AANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKT 177
            AA       +   +++    E  R  + +    K + QM + +    E L++E   R K 
Sbjct: 914  AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE----EQLEEEEAARQKL 969

Query: 178  IQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRK-----------------EALSKMTQII 220
                  ++     +  E+L + +  N L  +RK                 E    +T++ 
Sbjct: 970  QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 221  HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280
            ++ + +++ + +   ++ K RQ++  +   L             L   + +L+ QL K E
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 281  EQSTKMTYEGDPIPMQRTHMLERV 304
            E+        D    Q+ + L+++
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKI 1113


>gi|212276078 leucine rich repeat (in FLII) interacting protein 1
           isoform 1 [Homo sapiens]
          Length = 640

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 42/217 (19%), Positives = 92/217 (42%), Gaps = 19/217 (8%)

Query: 5   NQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQL 64
           +Q+Q +E K+++ + +  D    +E ++  A  + N   +    N       L+++L++L
Sbjct: 272 DQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAM-VSNAQLDNEKTNFMYQVDTLKDMLLEL 330

Query: 65  DEQLG---RVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANM 121
           +EQL    R  +EKN       K    +LQ +F          +   L++   +L     
Sbjct: 331 EEQLAESRRQYEEKNKEFERE-KHAHSILQFQF--------AEVKEALKQREEMLEEIRQ 381

Query: 122 PVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTM 181
             Q       + S + E     + K+ A++   +  +      +DL++E       +   
Sbjct: 382 LQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREE------VVMLK 435

Query: 182 DQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQ 218
           ++  K+  ++N E+ T  E  ++L+    +  +KMT+
Sbjct: 436 EELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTK 472


>gi|126362969 Nck-associated protein 5 isoform 2 [Homo sapiens]
          Length = 590

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 52/245 (21%), Positives = 98/245 (40%), Gaps = 53/245 (21%)

Query: 57  LQNLLIQLDEQLGRVSKEKNLLLIHNLKR--IRKVLQGKFHGNPMHVAVVISNCLREERR 114
           +++LL QL+EQ   + +EK  L +  L+R   ++  +G  H   +H        L EER 
Sbjct: 32  IEHLLTQLEEQHRSLWREK--LAVARLQREVAQRTSEGAMHEKLIHE-------LEEERH 82

Query: 115 ILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYR 174
           +   +        EK LQ  ++              +N +QM          LQ +F   
Sbjct: 83  LRLQS--------EKRLQEVTLESE-----------RNRIQM--------RSLQQQFSRM 115

Query: 175 YKTIQTMDQSDKNSAMVNQE---VLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNT-- 229
            +T++ + QS  +     +E   ++  QE L+  + K KEAL  +  ++ E     ++  
Sbjct: 116 EETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSST 175

Query: 230 --------MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEE 281
                   +L+E L+  +       +     N  +Q + C   +A  + Q     + L E
Sbjct: 176 DEGKEKTKLLLERLKALEAENSALALEN--ENQREQYERCLDEVANQVVQALLTQKDLRE 233

Query: 282 QSTKM 286
           +  K+
Sbjct: 234 ECVKL 238


>gi|126362967 Nck-associated protein 5 isoform 1 [Homo sapiens]
          Length = 1909

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 52/245 (21%), Positives = 98/245 (40%), Gaps = 53/245 (21%)

Query: 57  LQNLLIQLDEQLGRVSKEKNLLLIHNLKR--IRKVLQGKFHGNPMHVAVVISNCLREERR 114
           +++LL QL+EQ   + +EK  L +  L+R   ++  +G  H   +H        L EER 
Sbjct: 32  IEHLLTQLEEQHRSLWREK--LAVARLQREVAQRTSEGAMHEKLIHE-------LEEERH 82

Query: 115 ILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYR 174
           +   +        EK LQ  ++              +N +QM          LQ +F   
Sbjct: 83  LRLQS--------EKRLQEVTLESE-----------RNRIQM--------RSLQQQFSRM 115

Query: 175 YKTIQTMDQSDKNSAMVNQE---VLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNT-- 229
            +T++ + QS  +     +E   ++  QE L+  + K KEAL  +  ++ E     ++  
Sbjct: 116 EETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSST 175

Query: 230 --------MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEE 281
                   +L+E L+  +       +     N  +Q + C   +A  + Q     + L E
Sbjct: 176 DEGKEKTKLLLERLKALEAENSALALEN--ENQREQYERCLDEVANQVVQALLTQKDLRE 233

Query: 282 QSTKM 286
           +  K+
Sbjct: 234 ECVKL 238


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%)

Query: 110  REERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQD 169
            R++R +  AA   ++G LE+ L++   S  Q   E    A+K   +M  Q  +   ++++
Sbjct: 1634 RKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEE----AVKQLRKMQAQMKELWREVEE 1688

Query: 170  EFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHE--TDLLM 227
                R +      +S+K    +  EVL LQE L + D  R++A     ++  E     L 
Sbjct: 1689 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1748

Query: 228  NTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279
               ++EE      ++Q+    G L   L++ Q+   LL +   +L  Q+E L
Sbjct: 1749 KAAILEE------KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1794


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%)

Query: 110  REERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQD 169
            R++R +  AA   ++G LE+ L++   S  Q   E    A+K   +M  Q  +   ++++
Sbjct: 1626 RKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEE----AVKQLRKMQAQMKELWREVEE 1680

Query: 170  EFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHE--TDLLM 227
                R +      +S+K    +  EVL LQE L + D  R++A     ++  E     L 
Sbjct: 1681 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1740

Query: 228  NTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279
               ++EE      ++Q+    G L   L++ Q+   LL +   +L  Q+E L
Sbjct: 1741 KAAILEE------KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1786


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%)

Query: 110  REERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQD 169
            R++R +  AA   ++G LE+ L++   S  Q   E    A+K   +M  Q  +   ++++
Sbjct: 1667 RKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEE----AVKQLRKMQAQMKELWREVEE 1721

Query: 170  EFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHE--TDLLM 227
                R +      +S+K    +  EVL LQE L + D  R++A     ++  E     L 
Sbjct: 1722 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1781

Query: 228  NTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279
               ++EE      ++Q+    G L   L++ Q+   LL +   +L  Q+E L
Sbjct: 1782 KAAILEE------KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1827


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 38.5 bits (88), Expect = 0.023
 Identities = 53/249 (21%), Positives = 109/249 (43%), Gaps = 25/249 (10%)

Query: 44  EAASNNETMATILLQNLLIQLDEQ----LGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPM 99
           + AS    + T+   N  IQ  +Q    L + +KEK   L   L++  +  QG  H    
Sbjct: 499 QVASLTSELTTL---NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRH---- 551

Query: 100 HVAVVISNCLREERRILAAANMPVQGPLEKSLQ-SSSVSERQRNVEHKVAAIKNSVQMTE 158
            V  + S+  ++E+++   A        + + Q +++  ER+ ++  + AA+K    + +
Sbjct: 552 QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEK 611

Query: 159 QDTKYLEDLQDEF----DYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALS 214
           +    LE LQ +     + R     ++ Q+ +  A ++++V  LQ  + +   ++ EA +
Sbjct: 612 EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA 671

Query: 215 KMTQIIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESL-FQLR 273
           ++ +        +   L  E Q    ++++A     L   L  L+    +   SL  + R
Sbjct: 672 QVAE--------LELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723

Query: 274 RQLEKLEEQ 282
           R  + LEEQ
Sbjct: 724 RAADALEEQ 732


>gi|148612801 KIAA1009 protein [Homo sapiens]
          Length = 1403

 Score = 38.5 bits (88), Expect = 0.023
 Identities = 37/193 (19%), Positives = 92/193 (47%), Gaps = 20/193 (10%)

Query: 63   QLDEQLGRVSKEKNLLLIHN---LKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAA 119
            +L  +L  +  EKN L + +   + +    ++        H+A + ++  RE  ++L   
Sbjct: 1178 RLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLC-- 1235

Query: 120  NMPVQGPLEKSLQSSSVSERQRNVEHKVAAIK------NSVQMTEQDTKYLEDLQDEFDY 173
                Q  +E S  SS V+E  R +  +   I+      N +Q ++Q++  + ++++E   
Sbjct: 1236 ----QNAVENS--SSKVAELNRKIATQEVLIRHFQSQVNELQ-SKQESLVVSEVREEILQ 1288

Query: 174  RY--KTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTML 231
            +   K ++ + ++ +N     +  + L++ +  ++ +  +   ++ QII +T  ++ T  
Sbjct: 1289 KEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQ 1348

Query: 232  IEELQDWKRRQQI 244
             +E++ WKR  Q+
Sbjct: 1349 NKEVEKWKRLAQL 1361



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 6/78 (7%)

Query: 151  KNSVQMTEQDTKYLE-DLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEM-----LNS 204
            KN+V+  E+  K LE DL+ + +   K+++TM+Q  +   +  ++ L  QE      LN 
Sbjct: 959  KNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQ 1018

Query: 205  LDFKRKEALSKMTQIIHE 222
             D  R +AL K    I E
Sbjct: 1019 HDSPRIKALEKELDDIKE 1036


>gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo
           sapiens]
          Length = 805

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 50/240 (20%), Positives = 105/240 (43%), Gaps = 29/240 (12%)

Query: 51  TMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLR 110
           T+  +  Q+L +Q+ E+  +  +E  +     L+ I+K  Q K         ++   C +
Sbjct: 520 TLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDK------ETQLI---CQK 570

Query: 111 EERRILAAANMPVQGPLEKSLQSS----SVSERQRNVEHKVAAIKNSVQMTEQDTKYLED 166
           ++ + L      +Q  +E+ L+       +  +Q   E+      N  Q  E  +K ++ 
Sbjct: 571 KKEKELVTTVQSLQQKVERCLEDGIRLPMLDAKQLQNEND-----NLRQQNETASKIIDS 625

Query: 167 LQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLL 226
            QDE D     IQ+M         +++E LT Q+M+  L+ K++  + ++T+ + E    
Sbjct: 626 QQDEIDRMILEIQSM------QGKLSKEKLTTQKMMEELE-KKERNVQRLTKALLENQRQ 678

Query: 227 MN---TMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQS 283
            +   ++L +  +  + RQQ      PL + L  +   F  ++  LF L+     L +++
Sbjct: 679 TDETCSLLDQGQEPDQSRQQTVLSKRPLFD-LTVIDQLFKEMSCCLFDLKALCSILNQRA 737


>gi|24307983 FtsJ methyltransferase domain containing 2 [Homo
           sapiens]
          Length = 835

 Score = 35.8 bits (81), Expect = 0.15
 Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 3/92 (3%)

Query: 127 LEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQSDK 186
           L  SL S+S  E   +V H   A   S+  ++ +T+  +   D FD  +K    ++ +  
Sbjct: 23  LALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSS 82

Query: 187 NSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQ 218
             +M N      Q+++  + F+  E L K +Q
Sbjct: 83  RYSMYNS---VSQKLMAKMGFREGEGLGKYSQ 111


>gi|187761324 shootin1 isoform a [Homo sapiens]
          Length = 631

 Score = 35.8 bits (81), Expect = 0.15
 Identities = 73/392 (18%), Positives = 151/392 (38%), Gaps = 84/392 (21%)

Query: 50  ETMATILLQNLLIQLDEQLGRVSKEKNLLLIH--NLK--------RIRKVLQGKFHGNPM 99
           ET  ++  Q  + +L +Q+  V +EK +L I   NLK         + KV Q K      
Sbjct: 133 ETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEK------ 186

Query: 100 HVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQ 159
               V+++ + E+R++L   N      +E+  +     E ++++  K  +    + + + 
Sbjct: 187 ---TVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQN 243

Query: 160 DTKYLEDLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQI 219
             K                       + S ++ Q  +  Q++L +LD       +K+TQ 
Sbjct: 244 KLK-----------------------RQSHLLLQSSIPDQQLLKALDEN-----AKLTQQ 275

Query: 220 IHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279
           + E + + +   ++EL++    +        LH  +  L+    LL E   +L  + +  
Sbjct: 276 LEE-ERIQHQQKVKELEEQLENET-------LHKEIHNLKQQLELLEEDKKELELKYQNS 327

Query: 280 EEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQ 339
           EE++  + +  D +  +             N  +NS      P  P  P  P  +++L+ 
Sbjct: 328 EEKARNLKHSVDELQKR------------VNQSENSVPPPPPPPPPLPPPPPNPIRSLMS 375

Query: 340 FTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEF 399
              K       P  +   K KA+  +    +         T++K  ++EE  +     + 
Sbjct: 376 MIRKR----SHPSGSGAKKEKATQPETTEEV---------TDLKRQAVEEMMD--RIKKG 420

Query: 400 RHLQP--KEMKSSAGGKGNEGCHMVTEELHSI 429
            HL+P  +  +     + ++GC    +EL  I
Sbjct: 421 VHLRPVNQTARPKTKPESSKGCESAVDELKGI 452


>gi|50511340 shootin1 isoform b [Homo sapiens]
          Length = 456

 Score = 35.8 bits (81), Expect = 0.15
 Identities = 73/392 (18%), Positives = 151/392 (38%), Gaps = 84/392 (21%)

Query: 50  ETMATILLQNLLIQLDEQLGRVSKEKNLLLIH--NLK--------RIRKVLQGKFHGNPM 99
           ET  ++  Q  + +L +Q+  V +EK +L I   NLK         + KV Q K      
Sbjct: 133 ETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEK------ 186

Query: 100 HVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQ 159
               V+++ + E+R++L   N      +E+  +     E ++++  K  +    + + + 
Sbjct: 187 ---TVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQN 243

Query: 160 DTKYLEDLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQI 219
             K                       + S ++ Q  +  Q++L +LD       +K+TQ 
Sbjct: 244 KLK-----------------------RQSHLLLQSSIPDQQLLKALDEN-----AKLTQQ 275

Query: 220 IHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKL 279
           + E + + +   ++EL++    +        LH  +  L+    LL E   +L  + +  
Sbjct: 276 LEE-ERIQHQQKVKELEEQLENET-------LHKEIHNLKQQLELLEEDKKELELKYQNS 327

Query: 280 EEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQ 339
           EE++  + +  D +  +             N  +NS      P  P  P  P  +++L+ 
Sbjct: 328 EEKARNLKHSVDELQKR------------VNQSENSVPPPPPPPPPLPPPPPNPIRSLMS 375

Query: 340 FTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEF 399
              K       P  +   K KA+  +    +         T++K  ++EE  +     + 
Sbjct: 376 MIRKR----SHPSGSGAKKEKATQPETTEEV---------TDLKRQAVEEMMD--RIKKG 420

Query: 400 RHLQP--KEMKSSAGGKGNEGCHMVTEELHSI 429
            HL+P  +  +     + ++GC    +EL  I
Sbjct: 421 VHLRPVNQTARPKTKPESSKGCESAVDELKGI 452


>gi|38570058 hypothetical protein LOC80129 [Homo sapiens]
          Length = 715

 Score = 35.4 bits (80), Expect = 0.19
 Identities = 39/207 (18%), Positives = 88/207 (42%), Gaps = 34/207 (16%)

Query: 59  NLLIQLDEQLGRVSKE---KNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRI 115
           ++++   EQL R+      +N  + HNL+R  K  + +     +H++++     + E   
Sbjct: 459 DVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEE-- 516

Query: 116 LAAANMPVQGPLEKSLQSSSVSERQ------RNVEHKVAAIKNSVQ-MTEQDTKYLEDLQ 168
                       EK  +++ V ER       RN++ KV  ++  +    +  T+    L 
Sbjct: 517 ------------EKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLA 564

Query: 169 DEFDYRYKTIQ----------TMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQ 218
           D  + + KT++          + DQ +K      +++++++  L++ + + KE   +   
Sbjct: 565 DTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARN 624

Query: 219 IIHETDLLMNTMLIEELQDWKRRQQIA 245
           +I      M T+     +  KR +Q+A
Sbjct: 625 MIEVVTSEMKTLKKSLEEAEKREKQLA 651


>gi|7705415 hook homolog 1 [Homo sapiens]
          Length = 728

 Score = 35.4 bits (80), Expect = 0.19
 Identities = 32/128 (25%), Positives = 63/128 (49%), Gaps = 19/128 (14%)

Query: 176 KTIQTMDQSDKNSAMVNQEVLTLQEMLNS--------LDFKRKEALSKMTQIIHETDLLM 227
           + I T+++S ++  M   + L  +E+L+S        L+ + K AL ++ + + E + L 
Sbjct: 139 QNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELR 198

Query: 228 NT-----MLIEELQDWKRRQQIACIGGPLHNGLDQLQNCF----TLLAESLFQLRRQLEK 278
                  M +  LQD K    +      ++  LDQL   F    T++A+  F  + QLE+
Sbjct: 199 QRCEELDMQVTTLQDEKN--SLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQ 256

Query: 279 LEEQSTKM 286
           L+E++ ++
Sbjct: 257 LQEENFRL 264


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,865,364
Number of Sequences: 37866
Number of extensions: 1232747
Number of successful extensions: 4021
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 3851
Number of HSP's gapped (non-prelim): 217
length of query: 748
length of database: 18,247,518
effective HSP length: 110
effective length of query: 638
effective length of database: 14,082,258
effective search space: 8984480604
effective search space used: 8984480604
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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