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Search of human proteins with 4505731
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
(323 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 685 0.0
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 100 2e-21
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 100 2e-21
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 92 8e-19
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 90 2e-18
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 88 9e-18
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 88 9e-18
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 88 9e-18
gi|32189425 WD repeat domain 69 [Homo sapiens] 88 9e-18
gi|26665869 WD repeat domain 51B [Homo sapiens] 87 2e-17
gi|113865883 WD repeat domain 38 [Homo sapiens] 87 3e-17
gi|14149987 WD repeat domain 24 [Homo sapiens] 86 6e-17
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 86 6e-17
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 86 6e-17
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 86 6e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 85 1e-16
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 84 1e-16
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 84 1e-16
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 84 1e-16
gi|16554629 WD repeat domain 5 [Homo sapiens] 84 2e-16
gi|16554627 WD repeat domain 5 [Homo sapiens] 84 2e-16
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 82 5e-16
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 82 5e-16
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 82 5e-16
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 82 8e-16
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 82 8e-16
gi|4757988 WD repeat domain 39 [Homo sapiens] 82 8e-16
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 82 8e-16
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 80 2e-15
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 80 2e-15
>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
Length = 323
Score = 685 bits (1767), Expect = 0.0
Identities = 323/323 (100%), Positives = 323/323 (100%)
Query: 1 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL 60
MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL
Sbjct: 1 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL 60
Query: 61 FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS 120
FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS
Sbjct: 61 FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS 120
Query: 121 QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL 180
QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL
Sbjct: 121 QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL 180
Query: 181 RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG 240
RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG
Sbjct: 181 RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG 240
Query: 241 HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT 300
HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT
Sbjct: 241 HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT 300
Query: 301 QVADCSWDETIKIYDPACLTIPA 323
QVADCSWDETIKIYDPACLTIPA
Sbjct: 301 QVADCSWDETIKIYDPACLTIPA 323
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 100 bits (248), Expect = 2e-21
Identities = 70/250 (28%), Positives = 120/250 (48%), Gaps = 11/250 (4%)
Query: 70 LFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQE--VYSVDWSQTRGEQL 127
+FD + ++ ++L T S DG++++WD VY E +YS+ W+ G
Sbjct: 372 IFDCKFKPDDPNLLATASFDGTIKVWDINTLTA---VYTSPGNEGVIYSLSWAPG-GLNC 427
Query: 128 VVSGSWDQTVKLWDPTVGKSLCTFRGHESI-IYSTIWSPHIPGCFASASGDQTLRIWDVK 186
+ G+ +W+ GK + F H + I+ WS A+ S D I +
Sbjct: 428 IAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTID 487
Query: 187 AAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVR-QPVFELLGHTYAI 245
G + H A + CDW + N++++ TG D ++R + + QP+ GHT +
Sbjct: 488 --GKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKV 545
Query: 246 RRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADC 305
VK+SP +L S S D TVR W++++ D+ + + HT GL ++ + P +
Sbjct: 546 FHVKWSPLREGILCSGSDDGTVRIWDYTQ-DACINILNGHTAPVRGLMWNTEIPYLLISG 604
Query: 306 SWDETIKIYD 315
SWD TIK++D
Sbjct: 605 SWDYTIKVWD 614
Score = 91.7 bits (226), Expect = 8e-19
Identities = 80/303 (26%), Positives = 122/303 (40%), Gaps = 36/303 (11%)
Query: 14 TPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDV 73
+PG G S + PG L C G + G + ++ F N G+F +
Sbjct: 408 SPGNEGVIYSLS-WAPGGLNCIAG---GTSRNGAFIWNVQKGKIIQRFNEHGTN-GIFCI 462
Query: 74 TWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSW 133
WS + + TCS DG + L YK H V+ DWSQ + ++ +G
Sbjct: 463 AWSHKDSKRIATCSSDGFCIIRTIDGKV--LHKYK-HPAAVFGCDWSQNN-KDMIATGCE 518
Query: 134 DQTVKLWDPTVGKS--LCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVR 191
D V+++ L F GH + ++ WSP G S S D T+RIWD
Sbjct: 519 DTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACI 578
Query: 192 IVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFS 251
++ H A + W LL++G+ D +++ WD R V + H + +
Sbjct: 579 NILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE-GTCVDTVYDHGADVYGLTCH 637
Query: 252 PFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQV---ADCSWD 308
P +ASCS D TVR W+ + +L +P Q+ AD SW+
Sbjct: 638 PSRPFTMASCSRDSTVRLWSLT---------------------ALVTPVQINILADRSWE 676
Query: 309 ETI 311
E I
Sbjct: 677 EII 679
Score = 76.3 bits (186), Expect = 4e-14
Identities = 50/175 (28%), Positives = 83/175 (47%), Gaps = 8/175 (4%)
Query: 70 LFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVV 129
+F V WS E +L + S DG++++WD + A + + H V + W+ T L++
Sbjct: 545 VFHVKWSPLREGILCSGSDDGTVRIWDYTQDAC-INILNGHTAPVRGLMWN-TEIPYLLI 602
Query: 130 SGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAG 189
SGSWD T+K+WD G + T H + +Y P P AS S D T+R+W + A
Sbjct: 603 SGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA-- 660
Query: 190 VRIVIPAHQAEILSCDWCKY--NENLLVTGAVDCSLRGWDLRNVRQPVFELLGHT 242
+V P + W + N + + L G R++RQ + +L ++
Sbjct: 661 --LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANS 713
Score = 37.4 bits (85), Expect = 0.018
Identities = 19/61 (31%), Positives = 29/61 (47%)
Query: 154 HESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENL 213
H+ I + W PH P FAS S D + IW+V V + + + S WC E++
Sbjct: 58 HKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDV 117
Query: 214 L 214
+
Sbjct: 118 V 118
Score = 37.0 bits (84), Expect = 0.024
Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 5/122 (4%)
Query: 106 VYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSP 165
+ EH + + ++ W L SGS D V +W+ K + + I S W
Sbjct: 54 IMSEHKKTITAISWCP-HNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCW 112
Query: 166 HIPGCFASASGDQTLRIWDVKA--AGVRIVIPAHQ--AEILSCDWCKYNENLLVTGAVDC 221
+ A S L IW + +GV + AH ++I W + + +V G +D
Sbjct: 113 NAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDG 172
Query: 222 SL 223
SL
Sbjct: 173 SL 174
Score = 32.7 bits (73), Expect = 0.45
Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 3/86 (3%)
Query: 193 VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSP 252
++ H+ I + WC +N +L +G+ D + W++ Q V L T I
Sbjct: 54 IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNV--AEQKVIAKLDSTKGIPASLSWC 111
Query: 253 FHA-SVLASCSYDFTVRFWNFSKPDS 277
++A V+A S+ + W S PDS
Sbjct: 112 WNAEDVVAFVSHRGPLFIWTISGPDS 137
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 100 bits (248), Expect = 2e-21
Identities = 70/250 (28%), Positives = 120/250 (48%), Gaps = 11/250 (4%)
Query: 70 LFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQE--VYSVDWSQTRGEQL 127
+FD + ++ ++L T S DG++++WD VY E +YS+ W+ G
Sbjct: 396 IFDCKFKPDDPNLLATASFDGTIKVWDINTLTA---VYTSPGNEGVIYSLSWAPG-GLNC 451
Query: 128 VVSGSWDQTVKLWDPTVGKSLCTFRGHESI-IYSTIWSPHIPGCFASASGDQTLRIWDVK 186
+ G+ +W+ GK + F H + I+ WS A+ S D I +
Sbjct: 452 IAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTID 511
Query: 187 AAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVR-QPVFELLGHTYAI 245
G + H A + CDW + N++++ TG D ++R + + QP+ GHT +
Sbjct: 512 --GKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKV 569
Query: 246 RRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADC 305
VK+SP +L S S D TVR W++++ D+ + + HT GL ++ + P +
Sbjct: 570 FHVKWSPLREGILCSGSDDGTVRIWDYTQ-DACINILNGHTAPVRGLMWNTEIPYLLISG 628
Query: 306 SWDETIKIYD 315
SWD TIK++D
Sbjct: 629 SWDYTIKVWD 638
Score = 91.7 bits (226), Expect = 8e-19
Identities = 80/303 (26%), Positives = 122/303 (40%), Gaps = 36/303 (11%)
Query: 14 TPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDV 73
+PG G S + PG L C G + G + ++ F N G+F +
Sbjct: 432 SPGNEGVIYSLS-WAPGGLNCIAG---GTSRNGAFIWNVQKGKIIQRFNEHGTN-GIFCI 486
Query: 74 TWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSW 133
WS + + TCS DG + L YK H V+ DWSQ + ++ +G
Sbjct: 487 AWSHKDSKRIATCSSDGFCIIRTIDGKV--LHKYK-HPAAVFGCDWSQNN-KDMIATGCE 542
Query: 134 DQTVKLWDPTVGKS--LCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVR 191
D V+++ L F GH + ++ WSP G S S D T+RIWD
Sbjct: 543 DTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACI 602
Query: 192 IVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFS 251
++ H A + W LL++G+ D +++ WD R V + H + +
Sbjct: 603 NILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE-GTCVDTVYDHGADVYGLTCH 661
Query: 252 PFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQV---ADCSWD 308
P +ASCS D TVR W+ + +L +P Q+ AD SW+
Sbjct: 662 PSRPFTMASCSRDSTVRLWSLT---------------------ALVTPVQINILADRSWE 700
Query: 309 ETI 311
E I
Sbjct: 701 EII 703
Score = 76.3 bits (186), Expect = 4e-14
Identities = 50/175 (28%), Positives = 83/175 (47%), Gaps = 8/175 (4%)
Query: 70 LFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVV 129
+F V WS E +L + S DG++++WD + A + + H V + W+ T L++
Sbjct: 569 VFHVKWSPLREGILCSGSDDGTVRIWDYTQDAC-INILNGHTAPVRGLMWN-TEIPYLLI 626
Query: 130 SGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAG 189
SGSWD T+K+WD G + T H + +Y P P AS S D T+R+W + A
Sbjct: 627 SGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA-- 684
Query: 190 VRIVIPAHQAEILSCDWCKY--NENLLVTGAVDCSLRGWDLRNVRQPVFELLGHT 242
+V P + W + N + + L G R++RQ + +L ++
Sbjct: 685 --LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANS 737
Score = 37.4 bits (85), Expect = 0.018
Identities = 19/61 (31%), Positives = 29/61 (47%)
Query: 154 HESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENL 213
H+ I + W PH P FAS S D + IW+V V + + + S WC E++
Sbjct: 82 HKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDV 141
Query: 214 L 214
+
Sbjct: 142 V 142
Score = 37.0 bits (84), Expect = 0.024
Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 5/122 (4%)
Query: 106 VYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSP 165
+ EH + + ++ W L SGS D V +W+ K + + I S W
Sbjct: 78 IMSEHKKTITAISWCP-HNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCW 136
Query: 166 HIPGCFASASGDQTLRIWDVKA--AGVRIVIPAHQ--AEILSCDWCKYNENLLVTGAVDC 221
+ A S L IW + +GV + AH ++I W + + +V G +D
Sbjct: 137 NAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDG 196
Query: 222 SL 223
SL
Sbjct: 197 SL 198
Score = 32.7 bits (73), Expect = 0.45
Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 3/86 (3%)
Query: 193 VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSP 252
++ H+ I + WC +N +L +G+ D + W++ Q V L T I
Sbjct: 78 IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNV--AEQKVIAKLDSTKGIPASLSWC 135
Query: 253 FHA-SVLASCSYDFTVRFWNFSKPDS 277
++A V+A S+ + W S PDS
Sbjct: 136 WNAEDVVAFVSHRGPLFIWTISGPDS 161
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 91.7 bits (226), Expect = 8e-19
Identities = 71/271 (26%), Positives = 115/271 (42%), Gaps = 33/271 (12%)
Query: 79 NEHVLITCSGDGSLQLWDTAK---------AAGPLQVYKEHAQEVYSVDWSQTRGEQLVV 129
N H++ T + + ++D K P + H +E Y + W+ L+
Sbjct: 135 NPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLL- 193
Query: 130 SGSWDQTVKLWD----PTVGKSL---CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRI 182
S S D TV LWD P GK + F GH +++ W F S + DQ L I
Sbjct: 194 SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMI 253
Query: 183 WDVKA---AGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELL 239
WD ++ + ++ AH AE+ + Y+E +L TG+ D ++ WDLRN++ +
Sbjct: 254 WDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFE 313
Query: 240 GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK-------------PDSLLETVEHHT 286
H I +V +SP + ++LAS D + W+ SK P LL HT
Sbjct: 314 SHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHT 373
Query: 287 EFTCGLDFSLQSPTQVADCSWDETIKIYDPA 317
++ P + S D ++I+ A
Sbjct: 374 AKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
Score = 73.9 bits (180), Expect = 2e-13
Identities = 57/229 (24%), Positives = 100/229 (43%), Gaps = 28/229 (12%)
Query: 71 FDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQ--------VYKEHAQEVYSVDWSQT 122
+ ++W+ N L++ S D ++ LWD AGP + ++ H+ V V W
Sbjct: 180 YGLSWNSNLSGHLLSASDDHTVCLWDI--NAGPKEGKIVDAKAIFTGHSAVVEDVAWHLL 237
Query: 123 RGEQLVVSGSWDQTVKLWDP---TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQT 179
E L S + DQ + +WD T K H + + ++P+ A+ S D+T
Sbjct: 238 H-ESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKT 296
Query: 180 LRIWDVKAAGVRI-VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVF-- 236
+ +WD++ +++ +H+ EI W +NE +L + D L WDL + +
Sbjct: 297 VALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAE 356
Query: 237 -------ELL----GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK 274
ELL GHT I ++P V+ S S D ++ W ++
Sbjct: 357 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405
Score = 43.1 bits (100), Expect = 3e-04
Identities = 39/162 (24%), Positives = 59/162 (36%), Gaps = 38/162 (23%)
Query: 24 FSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVL 83
F+PY LA +A T+ + D L+L D +F V WS +NE +L
Sbjct: 280 FNPYSEFILATGSADK-------TVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETIL 332
Query: 84 ITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPT 143
+ D L +WD +K +E + D E L + G
Sbjct: 333 ASSGTDRRLNVWDLSKI----------GEEQSAEDAEDGPPELLFIHG------------ 370
Query: 144 VGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV 185
GH + I W+P+ P S S D ++IW +
Sbjct: 371 ---------GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 90.1 bits (222), Expect = 2e-18
Identities = 66/234 (28%), Positives = 112/234 (47%), Gaps = 12/234 (5%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
L +C+ DGS++LW + + P+ + H V V W + + + + +D++ +LWD
Sbjct: 296 LASCAADGSVKLW-SLDSDEPVADIEGHTVRVARVMWHPS--GRFLGTTCYDRSWRLWDL 352
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASG-DQTLRIWDVKAAGVRIVIPAHQAEI 201
+ + GH +Y + H G A G D R+WD++ + + H EI
Sbjct: 353 EAQEEILHQEGHSMGVYDIAF--HQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410
Query: 202 LSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASC 261
++ N + TG+ D + + WDLR R+ V+ + H + VKF P H + L +
Sbjct: 411 YGINFSP-NGYHIATGSGDNTCKVWDLRQ-RRCVYTIPAHQNLVTGVKFEPIHGNFLLTG 468
Query: 262 SYDFTVRFWNFSKPD-SLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIY 314
+YD T + W + P S L+T+ H GLD S +A CS+D T K++
Sbjct: 469 AYDNTAKIW--THPGWSPLKTLAGHEGKVMGLDISSDGQL-IATCSYDRTFKLW 519
Score = 79.0 bits (193), Expect = 5e-15
Identities = 59/201 (29%), Positives = 92/201 (45%), Gaps = 13/201 (6%)
Query: 73 VTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGS 132
V W + + TC D S +LWD +A + + H+ VY + + Q L +G
Sbjct: 329 VMWHPSGRFLGTTCY-DRSWRLWDL-EAQEEILHQEGHSMGVYDIAFHQDGS--LAGTGG 384
Query: 133 WDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSP---HIPGCFASASGDQTLRIWDVKAAG 189
D ++WD G+ + GH IY +SP HI A+ SGD T ++WD++
Sbjct: 385 LDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHI----ATGSGDNTCKVWDLRQRR 440
Query: 190 VRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVK 249
IPAHQ + + + N L+TGA D + + W P+ L GH + +
Sbjct: 441 CVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW-THPGWSPLKTLAGHEGKVMGLD 499
Query: 250 FSPFHASVLASCSYDFTVRFW 270
S ++A+CSYD T + W
Sbjct: 500 ISS-DGQLIATCSYDRTFKLW 519
Score = 47.4 bits (111), Expect = 2e-05
Identities = 47/209 (22%), Positives = 84/209 (40%), Gaps = 16/209 (7%)
Query: 126 QLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGC-------FASASGDQ 178
+++ + W KLW L T RGH + + + ++ P AS + D
Sbjct: 244 KMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADG 303
Query: 179 TLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFEL 238
++++W + + I H + W + L T D S R WDL ++ +
Sbjct: 304 SVKLWSLDSDEPVADIEGHTVRVARVMW-HPSGRFLGTTCYDRSWRLWDL-EAQEEILHQ 361
Query: 239 LGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQS 298
GH+ + + F S+ + D R W+ + + +E H + G++FS +
Sbjct: 362 EGHSMGVYDIAFHQ-DGSLAGTGGLDAFGRVWDL-RTGRCIMFLEGHLKEIYGINFS-PN 418
Query: 299 PTQVADCSWDETIKIYD----PACLTIPA 323
+A S D T K++D TIPA
Sbjct: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPA 447
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 88.2 bits (217), Expect = 9e-18
Identities = 63/231 (27%), Positives = 101/231 (43%), Gaps = 24/231 (10%)
Query: 110 HAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD----PTVGKSL---CTFRGHESIIYSTI 162
H +E Y + W+ L+ S S D T+ LWD P GK + F GH +++
Sbjct: 141 HQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 199
Query: 163 WSPHIPGCFASASGDQTLRIWDVKAAGVRIV---IPAHQAEILSCDWCKYNENLLVTGAV 219
W F S + DQ L IWD ++ + AH AE+ + Y+E +L TG+
Sbjct: 200 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 259
Query: 220 DCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK----- 274
D ++ WDLRN++ + H I +V++SP + ++LAS D + W+ SK
Sbjct: 260 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 319
Query: 275 --------PDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPA 317
P LL HT ++ P + S D ++++ A
Sbjct: 320 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 370
Score = 79.0 bits (193), Expect = 5e-15
Identities = 47/173 (27%), Positives = 78/173 (45%), Gaps = 9/173 (5%)
Query: 152 RGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV-------KAAGVRIVIPAHQAEILSC 204
RGH+ Y W+P++ G SAS D T+ +WD+ K + + H A +
Sbjct: 139 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 198
Query: 205 DWCKYNENLLVTGAVDCSLRGWDLR--NVRQPVFELLGHTYAIRRVKFSPFHASVLASCS 262
W +E+L + A D L WD R N +P + HT + + F+P+ +LA+ S
Sbjct: 199 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 258
Query: 263 YDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
D TV W+ L + E H + + +S + T +A D + ++D
Sbjct: 259 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311
Score = 72.8 bits (177), Expect = 4e-13
Identities = 54/227 (23%), Positives = 97/227 (42%), Gaps = 24/227 (10%)
Query: 71 FDVTWSENNEHVLITCSGDGSLQLWDTA------KAAGPLQVYKEHAQEVYSVDWSQTRG 124
+ ++W+ N L++ S D ++ LWD + K ++ H V V W
Sbjct: 146 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH- 204
Query: 125 EQLVVSGSWDQTVKLWDP---TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLR 181
E L S + DQ + +WD K + H + + ++P+ A+ S D+T+
Sbjct: 205 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 264
Query: 182 IWDVKAAGVRI-VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVF---- 236
+WD++ +++ +H+ EI W +NE +L + D L WDL + +
Sbjct: 265 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 324
Query: 237 -----ELL----GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK 274
ELL GHT I ++P V+ S S D ++ W ++
Sbjct: 325 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371
Score = 65.5 bits (158), Expect = 6e-11
Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 17/187 (9%)
Query: 12 LRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILD----PDEAGLRLFRS-FDW 66
LR + GY ++P L G L A+ H T+ + D P E + ++ F
Sbjct: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDH-------TICLWDISAVPKEGKVVDAKTIFTG 190
Query: 67 NDGLF-DVTWSENNEHVLITCSGDGSLQLWDTA--KAAGPLQVYKEHAQEVYSVDWSQTR 123
+ + DV+W +E + + + D L +WDT + P H EV + ++
Sbjct: 191 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN-PY 249
Query: 124 GEQLVVSGSWDQTVKLWD-PTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRI 182
E ++ +GS D+TV LWD + L +F H+ I+ WSPH AS+ D+ L +
Sbjct: 250 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 309
Query: 183 WDVKAAG 189
WD+ G
Sbjct: 310 WDLSKIG 316
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/162 (24%), Positives = 61/162 (37%), Gaps = 38/162 (23%)
Query: 24 FSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVL 83
F+PY LA +A T+ + D L+L D +F V WS +NE +L
Sbjct: 246 FNPYSEFILATGSADK-------TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 298
Query: 84 ITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPT 143
+ D L +WD +K + +E + E D E L + G
Sbjct: 299 ASSGTDRRLNVWDLSK------IGEEQSPE----DAEDGPPELLFIHG------------ 336
Query: 144 VGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV 185
GH + I W+P+ P S S D +++W +
Sbjct: 337 ---------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 369
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 88.2 bits (217), Expect = 9e-18
Identities = 63/231 (27%), Positives = 101/231 (43%), Gaps = 24/231 (10%)
Query: 110 HAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD----PTVGKSL---CTFRGHESIIYSTI 162
H +E Y + W+ L+ S S D T+ LWD P GK + F GH +++
Sbjct: 175 HQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 233
Query: 163 WSPHIPGCFASASGDQTLRIWDVKAAGVRIV---IPAHQAEILSCDWCKYNENLLVTGAV 219
W F S + DQ L IWD ++ + AH AE+ + Y+E +L TG+
Sbjct: 234 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 293
Query: 220 DCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK----- 274
D ++ WDLRN++ + H I +V++SP + ++LAS D + W+ SK
Sbjct: 294 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 353
Query: 275 --------PDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPA 317
P LL HT ++ P + S D ++++ A
Sbjct: 354 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 404
Score = 79.0 bits (193), Expect = 5e-15
Identities = 47/173 (27%), Positives = 78/173 (45%), Gaps = 9/173 (5%)
Query: 152 RGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV-------KAAGVRIVIPAHQAEILSC 204
RGH+ Y W+P++ G SAS D T+ +WD+ K + + H A +
Sbjct: 173 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 232
Query: 205 DWCKYNENLLVTGAVDCSLRGWDLR--NVRQPVFELLGHTYAIRRVKFSPFHASVLASCS 262
W +E+L + A D L WD R N +P + HT + + F+P+ +LA+ S
Sbjct: 233 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 292
Query: 263 YDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
D TV W+ L + E H + + +S + T +A D + ++D
Sbjct: 293 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 345
Score = 72.8 bits (177), Expect = 4e-13
Identities = 54/227 (23%), Positives = 97/227 (42%), Gaps = 24/227 (10%)
Query: 71 FDVTWSENNEHVLITCSGDGSLQLWDTA------KAAGPLQVYKEHAQEVYSVDWSQTRG 124
+ ++W+ N L++ S D ++ LWD + K ++ H V V W
Sbjct: 180 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH- 238
Query: 125 EQLVVSGSWDQTVKLWDP---TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLR 181
E L S + DQ + +WD K + H + + ++P+ A+ S D+T+
Sbjct: 239 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 298
Query: 182 IWDVKAAGVRI-VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVF---- 236
+WD++ +++ +H+ EI W +NE +L + D L WDL + +
Sbjct: 299 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 358
Query: 237 -----ELL----GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK 274
ELL GHT I ++P V+ S S D ++ W ++
Sbjct: 359 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 405
Score = 65.5 bits (158), Expect = 6e-11
Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 17/187 (9%)
Query: 12 LRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILD----PDEAGLRLFRS-FDW 66
LR + GY ++P L G L A+ H T+ + D P E + ++ F
Sbjct: 172 LRGHQKEGYGLSWNPNLSGHLLSASDDH-------TICLWDISAVPKEGKVVDAKTIFTG 224
Query: 67 NDGLF-DVTWSENNEHVLITCSGDGSLQLWDTA--KAAGPLQVYKEHAQEVYSVDWSQTR 123
+ + DV+W +E + + + D L +WDT + P H EV + ++
Sbjct: 225 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN-PY 283
Query: 124 GEQLVVSGSWDQTVKLWD-PTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRI 182
E ++ +GS D+TV LWD + L +F H+ I+ WSPH AS+ D+ L +
Sbjct: 284 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 343
Query: 183 WDVKAAG 189
WD+ G
Sbjct: 344 WDLSKIG 350
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/162 (24%), Positives = 61/162 (37%), Gaps = 38/162 (23%)
Query: 24 FSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVL 83
F+PY LA +A T+ + D L+L D +F V WS +NE +L
Sbjct: 280 FNPYSEFILATGSADK-------TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 332
Query: 84 ITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPT 143
+ D L +WD +K + +E + E D E L + G
Sbjct: 333 ASSGTDRRLNVWDLSK------IGEEQSPE----DAEDGPPELLFIHG------------ 370
Query: 144 VGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV 185
GH + I W+P+ P S S D +++W +
Sbjct: 371 ---------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 403
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 88.2 bits (217), Expect = 9e-18
Identities = 63/231 (27%), Positives = 101/231 (43%), Gaps = 24/231 (10%)
Query: 110 HAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD----PTVGKSL---CTFRGHESIIYSTI 162
H +E Y + W+ L+ S S D T+ LWD P GK + F GH +++
Sbjct: 176 HQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234
Query: 163 WSPHIPGCFASASGDQTLRIWDVKAAGVRIV---IPAHQAEILSCDWCKYNENLLVTGAV 219
W F S + DQ L IWD ++ + AH AE+ + Y+E +L TG+
Sbjct: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294
Query: 220 DCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK----- 274
D ++ WDLRN++ + H I +V++SP + ++LAS D + W+ SK
Sbjct: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354
Query: 275 --------PDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPA 317
P LL HT ++ P + S D ++++ A
Sbjct: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405
Score = 79.0 bits (193), Expect = 5e-15
Identities = 47/173 (27%), Positives = 78/173 (45%), Gaps = 9/173 (5%)
Query: 152 RGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV-------KAAGVRIVIPAHQAEILSC 204
RGH+ Y W+P++ G SAS D T+ +WD+ K + + H A +
Sbjct: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233
Query: 205 DWCKYNENLLVTGAVDCSLRGWDLR--NVRQPVFELLGHTYAIRRVKFSPFHASVLASCS 262
W +E+L + A D L WD R N +P + HT + + F+P+ +LA+ S
Sbjct: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293
Query: 263 YDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
D TV W+ L + E H + + +S + T +A D + ++D
Sbjct: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346
Score = 72.8 bits (177), Expect = 4e-13
Identities = 54/227 (23%), Positives = 97/227 (42%), Gaps = 24/227 (10%)
Query: 71 FDVTWSENNEHVLITCSGDGSLQLWDTA------KAAGPLQVYKEHAQEVYSVDWSQTRG 124
+ ++W+ N L++ S D ++ LWD + K ++ H V V W
Sbjct: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH- 239
Query: 125 EQLVVSGSWDQTVKLWDP---TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLR 181
E L S + DQ + +WD K + H + + ++P+ A+ S D+T+
Sbjct: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299
Query: 182 IWDVKAAGVRI-VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVF---- 236
+WD++ +++ +H+ EI W +NE +L + D L WDL + +
Sbjct: 300 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359
Query: 237 -----ELL----GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK 274
ELL GHT I ++P V+ S S D ++ W ++
Sbjct: 360 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406
Score = 65.5 bits (158), Expect = 6e-11
Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 17/187 (9%)
Query: 12 LRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILD----PDEAGLRLFRS-FDW 66
LR + GY ++P L G L A+ H T+ + D P E + ++ F
Sbjct: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDH-------TICLWDISAVPKEGKVVDAKTIFTG 225
Query: 67 NDGLF-DVTWSENNEHVLITCSGDGSLQLWDTA--KAAGPLQVYKEHAQEVYSVDWSQTR 123
+ + DV+W +E + + + D L +WDT + P H EV + ++
Sbjct: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN-PY 284
Query: 124 GEQLVVSGSWDQTVKLWD-PTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRI 182
E ++ +GS D+TV LWD + L +F H+ I+ WSPH AS+ D+ L +
Sbjct: 285 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344
Query: 183 WDVKAAG 189
WD+ G
Sbjct: 345 WDLSKIG 351
Score = 42.7 bits (99), Expect = 4e-04
Identities = 39/162 (24%), Positives = 61/162 (37%), Gaps = 38/162 (23%)
Query: 24 FSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVL 83
F+PY LA +A T+ + D L+L D +F V WS +NE +L
Sbjct: 281 FNPYSEFILATGSADK-------TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 333
Query: 84 ITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPT 143
+ D L +WD +K + +E + E D E L + G
Sbjct: 334 ASSGTDRRLNVWDLSK------IGEEQSPE----DAEDGPPELLFIHG------------ 371
Query: 144 VGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV 185
GH + I W+P+ P S S D +++W +
Sbjct: 372 ---------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 88.2 bits (217), Expect = 9e-18
Identities = 68/235 (28%), Positives = 114/235 (48%), Gaps = 10/235 (4%)
Query: 84 ITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPT 143
IT S D + +LWDTA L + H VY++ ++ G++ + +GS+D+T KLW
Sbjct: 108 ITGSYDRTCKLWDTASGE-ELNTLEGHRNVVYAIAFNNPYGDK-IATGSFDKTCKLWSVE 165
Query: 144 VGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILS 203
GK TFRGH + I ++P A+ S D T ++WD++ + H AEI+S
Sbjct: 166 TGKCYHTFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIIS 224
Query: 204 CDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSY 263
+ + + ++TG+ D ++ WD R+ V L+GH I F+ + S++ + S
Sbjct: 225 LSF-NTSGDRIITGSFDHTVVVWDADTGRK-VNILIGHCAEISSASFN-WDCSLILTGSM 281
Query: 264 DFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQ-SPTQVADCSWDETIKIYDPA 317
D T + W+ + + H E LD + +A S D T +I+ A
Sbjct: 282 DKTCKLWDATNGKCVATLTGHDDEI---LDSCFDYTGKLIATASADGTARIFSAA 333
Score = 70.9 bits (172), Expect = 1e-12
Identities = 56/188 (29%), Positives = 90/188 (47%), Gaps = 7/188 (3%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
+IT S D ++ +WD A + + H E+ S ++ L+++GS D+T KLWD
Sbjct: 234 IITGSFDHTVVVWD-ADTGRKVNILIGHCAEISSASFNWDCS--LILTGSMDKTCKLWDA 290
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEIL 202
T GK + T GH+ I + + + A+AS D T RI+ + H+ EI
Sbjct: 291 TNGKCVATLTGHDDEILDSCFD-YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEIS 349
Query: 203 SCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCS 262
+ +LL TG+ D + R WD + Q + L GHT I F+ + +++ + S
Sbjct: 350 KISFNPQGNHLL-TGSSDKTARIWDAQ-TGQCLQVLEGHTDEIFSCAFN-YKGNIVITGS 406
Query: 263 YDFTVRFW 270
D T R W
Sbjct: 407 KDNTCRIW 414
Score = 47.0 bits (110), Expect = 2e-05
Identities = 32/146 (21%), Positives = 69/146 (47%), Gaps = 4/146 (2%)
Query: 170 CFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLR 229
CF + S D+T ++WD + + H+ + + + + + TG+ D + + W +
Sbjct: 106 CFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV- 164
Query: 230 NVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFT 289
+ GHT I + F+P ++++A+ S D T + W+ + + T+ H+
Sbjct: 165 ETGKCYHTFRGHTAEIVCLSFNP-QSTLVATGSMDTTAKLWDIQNGEEVY-TLRGHSAEI 222
Query: 290 CGLDFSLQSPTQVADCSWDETIKIYD 315
L F+ S ++ S+D T+ ++D
Sbjct: 223 ISLSFN-TSGDRIITGSFDHTVVVWD 247
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 87.0 bits (214), Expect = 2e-17
Identities = 63/209 (30%), Positives = 103/209 (49%), Gaps = 8/209 (3%)
Query: 107 YKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPH 166
+K H + S+D S G+QL + SWD + LW+ + GH+ ++ S +SPH
Sbjct: 14 FKGHKAAITSLDLSPN-GKQLATA-SWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 167 IPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGW 226
ASAS D+T+R+W G AH A + S D+ + L T + D S++ W
Sbjct: 72 -GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF-SADGQFLATASEDKSIKVW 129
Query: 227 DLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHT 286
+ R ++ L HT+ +R KFSP ++ SCS D T++ W+ + +
Sbjct: 130 SMYRQRF-LYSLYRHTHWVRCAKFSP-DGRLIVSCSEDKTIKIWDTTN-KQCVNNFSDSV 186
Query: 287 EFTCGLDFSLQSPTQVADCSWDETIKIYD 315
F +DF+ S T +A D+T+K++D
Sbjct: 187 GFANFVDFN-PSGTCIASAGSDQTVKVWD 214
Score = 63.9 bits (154), Expect = 2e-10
Identities = 55/189 (29%), Positives = 88/189 (46%), Gaps = 9/189 (4%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
L T S D S+++W + +Y+ H V +S +L+VS S D+T+K+WD
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYR-HTHWVRCAKFSPDG--RLIVSCSEDKTIKIWDT 173
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHIPG-CFASASGDQTLRIWDVKAAGVRIVIPAHQAEI 201
T C +S+ ++ + G C ASA DQT+++WDV+ + H +
Sbjct: 174 T--NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV 231
Query: 202 LSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASC 261
+C + N L+T + D +L+ DL R ++ L GHT + V FS + AS
Sbjct: 232 -NCISFHPSGNYLITASSDGTLKILDLLEGRL-IYTLQGHTGPVFTVSFSK-GGELFASG 288
Query: 262 SYDFTVRFW 270
D V W
Sbjct: 289 GADTQVLLW 297
Score = 49.3 bits (116), Expect = 5e-06
Identities = 37/145 (25%), Positives = 68/145 (46%), Gaps = 5/145 (3%)
Query: 82 VLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD 141
++++CS D ++++WDT + + + VD++ + G + +GS DQTVK+WD
Sbjct: 158 LIVSCSEDKTIKIWDTTNKQ-CVNNFSDSVGFANFVDFNPS-GTCIASAGS-DQTVKVWD 214
Query: 142 PTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEI 201
V K L ++ H + + P +AS D TL+I D+ + + H +
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPS-GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273
Query: 202 LSCDWCKYNENLLVTGAVDCSLRGW 226
+ + K E L +G D + W
Sbjct: 274 FTVSFSKGGE-LFASGGADTQVLLW 297
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 86.7 bits (213), Expect = 3e-17
Identities = 66/198 (33%), Positives = 99/198 (50%), Gaps = 19/198 (9%)
Query: 81 HVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLW 140
H+ + S D +++LWD A+A L+V K H + V +V +S + + SG WD+ V LW
Sbjct: 76 HLFASASCDCTVRLWDVARAKC-LRVLKGHQRSVETVSFSPDSRQ--LASGGWDKRVMLW 132
Query: 141 DPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPA--HQ 198
D G+ L GH I S+ +SP + C A+ S D T+ IWD +R+V PA HQ
Sbjct: 133 DVQSGQMLRLLVGHRDSIQSSDFSPTV-NCLATGSWDSTVHIWD-----LRMVTPAVSHQ 186
Query: 199 A-----EILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPF 253
A +SC C LL +G+ D ++ W + +L GH ++ + FSP
Sbjct: 187 ALEGHSANISC-LCYSASGLLASGSWDKTIHIWK-PTTSSLLIQLKGHVTWVKSIAFSP- 243
Query: 254 HASVLASCSYDFTVRFWN 271
LAS Y V+ W+
Sbjct: 244 DELWLASAGYSRMVKVWD 261
Score = 77.4 bits (189), Expect = 2e-14
Identities = 72/265 (27%), Positives = 120/265 (45%), Gaps = 11/265 (4%)
Query: 53 PDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQ 112
P +R + F + G + + + +L+T S DG + W+T ++ L H
Sbjct: 6 PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWET-RSGQLLWRLGGHTG 64
Query: 113 EVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFA 172
V +S L S S D TV+LWD K L +GH+ + + +SP A
Sbjct: 65 PVKFCRFSPDG--HLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ-LA 121
Query: 173 SASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVR 232
S D+ + +WDV++ + ++ H+ I S D+ N L TG+ D ++ WDLR V
Sbjct: 122 SGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP-TVNCLATGSWDSTVHIWDLRMVT 180
Query: 233 QPVFE--LLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTC 290
V L GH+ I + +S + +LAS S+D T+ W SLL ++ H +
Sbjct: 181 PAVSHQALEGHSANISCLCYSA--SGLLASGSWDKTIHIWK-PTTSSLLIQLKGHVTWVK 237
Query: 291 GLDFSLQSPTQVADCSWDETIKIYD 315
+ FS +A + +K++D
Sbjct: 238 SIAFS-PDELWLASAGYSRMVKVWD 261
Score = 74.3 bits (181), Expect = 1e-13
Identities = 66/217 (30%), Positives = 107/217 (49%), Gaps = 14/217 (6%)
Query: 104 LQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIW 163
++ + +H EV S +S Q++++GS D V W+ G+ L GH + +
Sbjct: 14 VKFFGQHGGEVNSSAFSPDG--QMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
Query: 164 SP--HIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDC 221
SP H+ FASAS D T+R+WDV A V+ HQ + + + + L +G D
Sbjct: 72 SPDGHL---FASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP-DSRQLASGGWDK 127
Query: 222 SLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFS--KPDSLL 279
+ WD+++ Q + L+GH +I+ FSP + LA+ S+D TV W+ P
Sbjct: 128 RVMLWDVQS-GQMLRLLVGHRDSIQSSDFSP-TVNCLATGSWDSTVHIWDLRMVTPAVSH 185
Query: 280 ETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDP 316
+ +E H+ L +S +A SWD+TI I+ P
Sbjct: 186 QALEGHSANISCLCYSASG--LLASGSWDKTIHIWKP 220
Score = 52.0 bits (123), Expect = 7e-07
Identities = 37/144 (25%), Positives = 66/144 (45%), Gaps = 7/144 (4%)
Query: 83 LITCSGDGSLQLWDTAKAAGPL--QVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLW 140
L T S D ++ +WD + Q + H+ + + +S + L+ SGSWD+T+ +W
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDKTIHIW 218
Query: 141 DPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAE 200
PT L +GH + + S +SP ASA + +++WD +
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPD-ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
Query: 201 ILSCDWCKYNENLLVTGAVDCSLR 224
+C + + +LV+GA D + R
Sbjct: 278 AHTCAFTP-DGKILVSGAADQTRR 300
Score = 48.1 bits (113), Expect = 1e-05
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 10/172 (5%)
Query: 151 FRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYN 210
F H + S+ +SP + S D + W+ ++ + + H + C + +
Sbjct: 17 FGQHGGEVNSSAFSPD-GQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP-D 74
Query: 211 ENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFW 270
+L + + DC++R WD+ + + L GH ++ V FSP + LAS +D V W
Sbjct: 75 GHLFASASCDCTVRLWDVARAKC-LRVLKGHQRSVETVSFSP-DSRQLASGGWDKRVMLW 132
Query: 271 NFSKPDSLLETVEHHTEFTCGLDFSLQSPTQ--VADCSWDETIKIYDPACLT 320
+ L V H DFS PT +A SWD T+ I+D +T
Sbjct: 133 DVQSGQMLRLLVGHRDSIQSS-DFS---PTVNCLATGSWDSTVHIWDLRMVT 180
>gi|14149987 WD repeat domain 24 [Homo sapiens]
Length = 790
Score = 85.5 bits (210), Expect = 6e-17
Identities = 62/244 (25%), Positives = 107/244 (43%), Gaps = 6/244 (2%)
Query: 54 DEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQ--VYKEHA 111
++ LR+ R N DV W + +E++L T + +G + W+ + + Q ++ EH
Sbjct: 61 EKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHK 120
Query: 112 QEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCF 171
+ V V + T L+ SGS D +K +D S+ TF G + +S F
Sbjct: 121 RTVNKVCFHPTEAHVLL-SGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTF 179
Query: 172 ASASGDQTLRIWDVKAAG-VRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRN 230
AS + +++WD++ + AH + CDW + L TG D ++ WD+
Sbjct: 180 ASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTT 239
Query: 231 VRQPVFELLGHTYAIRRVKFSPFHASVLASCS--YDFTVRFWNFSKPDSLLETVEHHTEF 288
R + ++ RVK+ P LA+CS D + W+ +P E H +
Sbjct: 240 HRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDV 299
Query: 289 TCGL 292
T G+
Sbjct: 300 TTGI 303
Score = 37.4 bits (85), Expect = 0.018
Identities = 18/67 (26%), Positives = 30/67 (44%), Gaps = 2/67 (2%)
Query: 73 VTWSENNEHVLITCSG--DGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVS 130
V W H L TCS D ++ +WD + P +++EH + W ++S
Sbjct: 257 VKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLS 316
Query: 131 GSWDQTV 137
GS D ++
Sbjct: 317 GSKDSSL 323
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 85.5 bits (210), Expect = 6e-17
Identities = 49/144 (34%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
L++ S D +L LW A+ PL H + V +S ++V S S+D+++KLWD
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD--SRIVASASFDKSIKLWDG 109
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEIL 202
GK L + RGH + +Y WS S S D TL++WDVKA + + +P H E+
Sbjct: 110 RTGKYLASLRGHVAAVYQIAWSAD-SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVY 168
Query: 203 SCDWCKYNENLLVTGAVDCSLRGW 226
+ DW + + +G D LR W
Sbjct: 169 AVDWSPDGQR-VASGGKDKCLRIW 191
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/170 (31%), Positives = 86/170 (50%), Gaps = 7/170 (4%)
Query: 102 GPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKS-LCTFRGHESIIYS 160
G LQ KE A Y++ Q G + +VSGS D T+ LW P K L GH+++I
Sbjct: 28 GSLQELKERALSRYNLVRGQ--GPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQ 85
Query: 161 TIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVD 220
++SP ASAS D+++++WD + + H A + W + LLV+G+ D
Sbjct: 86 VLFSPD-SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAW-SADSRLLVSGSSD 143
Query: 221 CSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFW 270
+L+ WD++ ++ +L GH + V +SP +AS D +R W
Sbjct: 144 STLKVWDVK-AQKLAMDLPGHADEVYAVDWSP-DGQRVASGGKDKCLRIW 191
Score = 46.2 bits (108), Expect = 4e-05
Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 214 LVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFS 273
LV+G+ D +L W ++P+ + GH I +V FSP + ++AS S+D +++ W+
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-G 109
Query: 274 KPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
+ L ++ H + +S S V+ S D T+K++D
Sbjct: 110 RTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS-DSTLKVWD 150
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 85.5 bits (210), Expect = 6e-17
Identities = 49/144 (34%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
L++ S D +L LW A+ PL H + V +S ++V S S+D+++KLWD
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD--SRIVASASFDKSIKLWDG 401
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEIL 202
GK L + RGH + +Y WS S S D TL++WDVKA + + +P H E+
Sbjct: 402 RTGKYLASLRGHVAAVYQIAWSAD-SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVY 460
Query: 203 SCDWCKYNENLLVTGAVDCSLRGW 226
+ DW + + +G D LR W
Sbjct: 461 AVDWSPDGQR-VASGGKDKCLRIW 483
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/170 (31%), Positives = 86/170 (50%), Gaps = 7/170 (4%)
Query: 102 GPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKS-LCTFRGHESIIYS 160
G LQ KE A Y++ Q G + +VSGS D T+ LW P K L GH+++I
Sbjct: 320 GSLQELKERALSRYNLVRGQ--GPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQ 377
Query: 161 TIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVD 220
++SP ASAS D+++++WD + + H A + W + LLV+G+ D
Sbjct: 378 VLFSPD-SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA-DSRLLVSGSSD 435
Query: 221 CSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFW 270
+L+ WD++ ++ +L GH + V +SP +AS D +R W
Sbjct: 436 STLKVWDVK-AQKLAMDLPGHADEVYAVDWSP-DGQRVASGGKDKCLRIW 483
Score = 72.8 bits (177), Expect = 4e-13
Identities = 74/288 (25%), Positives = 125/288 (43%), Gaps = 33/288 (11%)
Query: 43 AGC--GTLLILDPD---EAGLRLFRSFDWNDGLFDVTWSENNE-HVLITCSGDGSLQLWD 96
+GC G +L+ DP + G L W GL N E + + S DGS+++WD
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 97 TAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHES 156
T A ++ H Q V + W G+ L+ S S D+T+K+W G T +GH
Sbjct: 233 TT-AGRCERILTGHTQSVTCLRWG---GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGH 288
Query: 157 IIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIV---IPAHQAEILSCDWCKYN--- 210
+ + + S D LR + A + + E+ +YN
Sbjct: 289 WVNTM-----------ALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337
Query: 211 ---ENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTV 267
LV+G+ D +L W ++P+ + GH I +V FSP + ++AS S+D ++
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSI 396
Query: 268 RFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
+ W+ + L ++ H + +S S V+ S D T+K++D
Sbjct: 397 KLWD-GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS-DSTLKVWD 442
Score = 52.4 bits (124), Expect = 5e-07
Identities = 49/181 (27%), Positives = 77/181 (42%), Gaps = 12/181 (6%)
Query: 110 HAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPG 169
H++ V SV +S T + + SGS D TV+ WD + T +GH + S WSP
Sbjct: 113 HSEAVISVAFSPTG--KYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
Query: 170 CFASASGDQTLRIWDVKAA-GVRIVIPAHQAEILSCDWCKYNEN----LLVTGAVDCSLR 224
+ Q L +WD V + H I W + N + + + D S+R
Sbjct: 171 LASGCKNGQIL-LWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
Query: 225 GWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEH 284
WD R L GHT ++ +++ +L S S D T++ W + L T++
Sbjct: 230 IWDTTAGRCERI-LTGHTQSVTCLRWG--GDGLLYSASQDRTIKVWR-AHDGVLCRTLQG 285
Query: 285 H 285
H
Sbjct: 286 H 286
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 85.5 bits (210), Expect = 6e-17
Identities = 57/194 (29%), Positives = 95/194 (48%), Gaps = 8/194 (4%)
Query: 85 TCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWD--QTVKLWDP 142
TCS DG++++WD + ++ + H +V VDW T+G LVVSGS D Q +K WDP
Sbjct: 219 TCSDDGTVRIWDFLRCHEE-RILRGHGADVKCVDWHPTKG--LVVSGSKDSQQPIKFWDP 275
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRI-VIPAHQAEI 201
G+SL T H++ + + + +AS D +++D++ + V H+ E
Sbjct: 276 KTGQSLATLHAHKNTVMEVKLNLN-GNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEA 334
Query: 202 LSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASC 261
+ W +E L +G D SL W + ++ + H I + + P +L S
Sbjct: 335 TAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPL-GHILCSG 393
Query: 262 SYDFTVRFWNFSKP 275
S D T +FW ++P
Sbjct: 394 SNDHTSKFWTRNRP 407
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/245 (20%), Positives = 90/245 (36%), Gaps = 49/245 (20%)
Query: 70 LFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVV 129
+F V W+ L+T + G LW+ + + H V ++ WS + ++
Sbjct: 122 VFVVRWTPEGRR-LVTGASSGEFTLWN-GLTFNFETILQAHDSPVRAMTWSHN--DMWML 177
Query: 130 SGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAG 189
+ VK W + ++ F+ H+ I +SP FA+ S D T+RIWD
Sbjct: 178 TADHGGYVKYWQSNMN-NVKMFQAHKEAIREASFSP-TDNKFATCSDDGTVRIWDFLRCH 235
Query: 190 VRIVIPAHQAEILSCDW------------------------------------------- 206
++ H A++ DW
Sbjct: 236 EERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVK 295
Query: 207 CKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFT 266
N N L+T + D + +D+RN+++ + GH V + P H + AS D +
Sbjct: 296 LNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGS 355
Query: 267 VRFWN 271
+ FW+
Sbjct: 356 LLFWH 360
Score = 49.3 bits (116), Expect = 5e-06
Identities = 33/106 (31%), Positives = 48/106 (45%), Gaps = 3/106 (2%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVK 138
N + L+T S D +L+D LQV++ H +E +V W E L SG D ++
Sbjct: 299 NGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVH-EGLFASGGSDGSLL 357
Query: 139 LWDPTVGKSLCTFR-GHESIIYSTIWSPHIPGCFASASGDQTLRIW 183
W V K + HE +I+S W P + S S D T + W
Sbjct: 358 FWHVGVEKEVGGMEMAHEGMIWSLAWHP-LGHILCSGSNDHTSKFW 402
Score = 30.4 bits (67), Expect = 2.2
Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 6/70 (8%)
Query: 73 VTWSENNEHVLITCSGDGSLQLWDTA--KAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVS 130
V W +E + + DGSL W K G +++ H ++S+ W ++ S
Sbjct: 337 VAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEM--AHEGMIWSLAWHPL--GHILCS 392
Query: 131 GSWDQTVKLW 140
GS D T K W
Sbjct: 393 GSNDHTSKFW 402
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 84.7 bits (208), Expect = 1e-16
Identities = 70/268 (26%), Positives = 126/268 (47%), Gaps = 30/268 (11%)
Query: 68 DGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQL 127
D + D+++ + + +L +CS D +++LWD + ++ H V SV G+
Sbjct: 151 DSVQDISFDHSGK-LLASCSADMTIKLWDF-QGFECIRTMHGHDHNVSSVA-IMPNGDH- 206
Query: 128 VVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPG-CFASASGDQTLRIWDVK 186
+VS S D+T+K+W+ G + TF GH + + P+ G AS S DQT+R+W V
Sbjct: 207 IVSASRDKTIKMWEVQTGYCVKTFTGHRE--WVRMVRPNQDGTLIASCSNDQTVRVWVVA 264
Query: 187 AAGVRIVIPAHQAEILSCDWCKYNE-------------------NLLVTGAVDCSLRGWD 227
+ + H+ + W + L++G+ D +++ WD
Sbjct: 265 TKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324
Query: 228 LRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTE 287
+ + + L+GH +R V F +L SC+ D T+R W++ K ++T+ H
Sbjct: 325 V-STGMCLMTLVGHDNWVRGVLFHSGGKFIL-SCADDKTLRVWDY-KNKRCMKTLNAHEH 381
Query: 288 FTCGLDFSLQSPTQVADCSWDETIKIYD 315
F LDF +P V S D+T+K+++
Sbjct: 382 FVTSLDFHKTAP-YVVTGSVDQTVKVWE 408
Score = 70.9 bits (172), Expect = 1e-12
Identities = 47/167 (28%), Positives = 84/167 (50%), Gaps = 23/167 (13%)
Query: 82 VLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDW---------SQTRGEQ------ 126
++ +CS D ++++W A ++ +EH V + W S+ G +
Sbjct: 248 LIASCSNDQTVRVWVVATKECKAEL-REHEHVVECISWAPESSYSSISEATGSETKKSGK 306
Query: 127 ---LVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCF-ASASGDQTLRI 182
++SGS D+T+K+WD + G L T GH++ + ++ H G F S + D+TLR+
Sbjct: 307 PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF--HSGGKFILSCADDKTLRV 364
Query: 183 WDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLR 229
WD K + AH+ + S D+ K +VTG+VD +++ W+ R
Sbjct: 365 WDYKNKRCMKTLNAHEHFVTSLDFHK-TAPYVVTGSVDQTVKVWECR 410
Score = 61.6 bits (148), Expect = 9e-10
Identities = 50/190 (26%), Positives = 85/190 (44%), Gaps = 4/190 (2%)
Query: 127 LVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVK 186
++VS S D T+K+WD G T +GH + I H AS S D T+++WD +
Sbjct: 122 VMVSASEDATIKVWDYETGDFERTLKGHTDSV-QDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 187 AAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIR 246
+ H + S N + +V+ + D +++ W+++ V GH +R
Sbjct: 181 GFECIRTMHGHDHNVSSVA-IMPNGDHIVSASRDKTIKMWEVQ-TGYCVKTFTGHREWVR 238
Query: 247 RVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCS 306
V+ + +++ASCS D TVR W + + E EH C S + +++ +
Sbjct: 239 MVRPNQ-DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEAT 297
Query: 307 WDETIKIYDP 316
ET K P
Sbjct: 298 GSETKKSGKP 307
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 84.3 bits (207), Expect = 1e-16
Identities = 69/252 (27%), Positives = 117/252 (46%), Gaps = 38/252 (15%)
Query: 46 GTLLILDPDEAGL------RLFRSFDWNDGLFDVTWSENNEHVL---------ITCSGDG 90
G++L L DE + R +D N G T +NE VL +TCS D
Sbjct: 281 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 340
Query: 91 SLQLWDTAKAAGPL--QVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSL 148
S+ +WD A A +V H V VD+ ++ +VS S D+T+K+W + + +
Sbjct: 341 SIAVWDMASATDITLRRVLVGHRAAVNVVDFD----DKYIVSASGDRTIKVWSTSTCEFV 396
Query: 149 CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCK 208
T GH+ I + + S S D T+R+WD++ V+ H+ E++ C +
Sbjct: 397 RTLNGHKRGIACLQYRDRL---VVSGSSDNTIRLWDIECGACLRVLEGHE-ELVRC--IR 450
Query: 209 YNENLLVTGAVDCSLRGWDLRNVRQP--------VFELLGHTYAIRRVKFSPFHASVLAS 260
++ +V+GA D ++ WDL+ P + L+ H+ + R++F F + S
Sbjct: 451 FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ---IIS 507
Query: 261 CSYDFTVRFWNF 272
S+D T+ W+F
Sbjct: 508 SSHDDTILIWDF 519
Score = 67.0 bits (162), Expect = 2e-11
Identities = 57/240 (23%), Positives = 115/240 (47%), Gaps = 22/240 (9%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVK 138
++ +I+ D S+++WD L+V H V + + E+++V+GS D TV+
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLEC-LKVLTGHTGSVLCLQYD----ERVIVTGSSDSTVR 303
Query: 139 LWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAA---GVRIVIP 195
+WD G+ L T H + +S G + S D+++ +WD+ +A +R V+
Sbjct: 304 VWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVWDMASATDITLRRVLV 360
Query: 196 AHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHA 255
H+A + D +++ +V+ + D +++ W + + V L GH R + +
Sbjct: 361 GHRAAVNVVD---FDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHK---RGIACLQYRD 413
Query: 256 SVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
++ S S D T+R W+ + + L +E H E + F + ++ ++D IK++D
Sbjct: 414 RLVVSGSSDNTIRLWDI-ECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWD 469
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/163 (22%), Positives = 78/163 (47%), Gaps = 22/163 (13%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVK 138
++ +++ SGD ++++W T+ ++ H + + + + ++LVVSGS D T++
Sbjct: 372 DDKYIVSASGDRTIKVWSTSTCEF-VRTLNGHKRGIACLQYR----DRLVVSGSSDNTIR 426
Query: 139 LWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAA---------- 188
LWD G L GHE ++ + S + D +++WD++AA
Sbjct: 427 LWDIECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWDLQAALDPRAPASTL 483
Query: 189 GVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNV 231
+R ++ H + +++E +++ + D ++ WD NV
Sbjct: 484 CLRTLV-EHSGRVFR---LQFDEFQIISSSHDDTILIWDFLNV 522
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 84.3 bits (207), Expect = 1e-16
Identities = 69/252 (27%), Positives = 117/252 (46%), Gaps = 38/252 (15%)
Query: 46 GTLLILDPDEAGL------RLFRSFDWNDGLFDVTWSENNEHVL---------ITCSGDG 90
G++L L DE + R +D N G T +NE VL +TCS D
Sbjct: 247 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 306
Query: 91 SLQLWDTAKAAGPL--QVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSL 148
S+ +WD A A +V H V VD+ ++ +VS S D+T+K+W + + +
Sbjct: 307 SIAVWDMASATDITLRRVLVGHRAAVNVVDFD----DKYIVSASGDRTIKVWSTSTCEFV 362
Query: 149 CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCK 208
T GH+ I + + S S D T+R+WD++ V+ H+ E++ C +
Sbjct: 363 RTLNGHKRGIACLQYRDRL---VVSGSSDNTIRLWDIECGACLRVLEGHE-ELVRC--IR 416
Query: 209 YNENLLVTGAVDCSLRGWDLRNVRQP--------VFELLGHTYAIRRVKFSPFHASVLAS 260
++ +V+GA D ++ WDL+ P + L+ H+ + R++F F + S
Sbjct: 417 FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ---IIS 473
Query: 261 CSYDFTVRFWNF 272
S+D T+ W+F
Sbjct: 474 SSHDDTILIWDF 485
Score = 67.0 bits (162), Expect = 2e-11
Identities = 57/240 (23%), Positives = 115/240 (47%), Gaps = 22/240 (9%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVK 138
++ +I+ D S+++WD L+V H V + + E+++V+GS D TV+
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLEC-LKVLTGHTGSVLCLQYD----ERVIVTGSSDSTVR 269
Query: 139 LWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAA---GVRIVIP 195
+WD G+ L T H + +S G + S D+++ +WD+ +A +R V+
Sbjct: 270 VWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVWDMASATDITLRRVLV 326
Query: 196 AHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHA 255
H+A + D +++ +V+ + D +++ W + + V L GH R + +
Sbjct: 327 GHRAAVNVVD---FDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHK---RGIACLQYRD 379
Query: 256 SVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
++ S S D T+R W+ + + L +E H E + F + ++ ++D IK++D
Sbjct: 380 RLVVSGSSDNTIRLWDI-ECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWD 435
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/163 (22%), Positives = 78/163 (47%), Gaps = 22/163 (13%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVK 138
++ +++ SGD ++++W T+ ++ H + + + + ++LVVSGS D T++
Sbjct: 338 DDKYIVSASGDRTIKVWSTSTCEF-VRTLNGHKRGIACLQYR----DRLVVSGSSDNTIR 392
Query: 139 LWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAA---------- 188
LWD G L GHE ++ + S + D +++WD++AA
Sbjct: 393 LWDIECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWDLQAALDPRAPASTL 449
Query: 189 GVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNV 231
+R ++ H + +++E +++ + D ++ WD NV
Sbjct: 450 CLRTLV-EHSGRVFR---LQFDEFQIISSSHDDTILIWDFLNV 488
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 84.3 bits (207), Expect = 1e-16
Identities = 69/252 (27%), Positives = 117/252 (46%), Gaps = 38/252 (15%)
Query: 46 GTLLILDPDEAGL------RLFRSFDWNDGLFDVTWSENNEHVL---------ITCSGDG 90
G++L L DE + R +D N G T +NE VL +TCS D
Sbjct: 268 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 327
Query: 91 SLQLWDTAKAAGPL--QVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSL 148
S+ +WD A A +V H V VD+ ++ +VS S D+T+K+W + + +
Sbjct: 328 SIAVWDMASATDITLRRVLVGHRAAVNVVDFD----DKYIVSASGDRTIKVWSTSTCEFV 383
Query: 149 CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCK 208
T GH+ I + + S S D T+R+WD++ V+ H+ E++ C +
Sbjct: 384 RTLNGHKRGIACLQYRDRL---VVSGSSDNTIRLWDIECGACLRVLEGHE-ELVRC--IR 437
Query: 209 YNENLLVTGAVDCSLRGWDLRNVRQP--------VFELLGHTYAIRRVKFSPFHASVLAS 260
++ +V+GA D ++ WDL+ P + L+ H+ + R++F F + S
Sbjct: 438 FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ---IIS 494
Query: 261 CSYDFTVRFWNF 272
S+D T+ W+F
Sbjct: 495 SSHDDTILIWDF 506
Score = 67.0 bits (162), Expect = 2e-11
Identities = 57/240 (23%), Positives = 115/240 (47%), Gaps = 22/240 (9%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVK 138
++ +I+ D S+++WD L+V H V + + E+++V+GS D TV+
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLEC-LKVLTGHTGSVLCLQYD----ERVIVTGSSDSTVR 290
Query: 139 LWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAA---GVRIVIP 195
+WD G+ L T H + +S G + S D+++ +WD+ +A +R V+
Sbjct: 291 VWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVWDMASATDITLRRVLV 347
Query: 196 AHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHA 255
H+A + D +++ +V+ + D +++ W + + V L GH R + +
Sbjct: 348 GHRAAVNVVD---FDDKYIVSASGDRTIKVWS-TSTCEFVRTLNGHK---RGIACLQYRD 400
Query: 256 SVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
++ S S D T+R W+ + + L +E H E + F + ++ ++D IK++D
Sbjct: 401 RLVVSGSSDNTIRLWDI-ECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWD 456
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/163 (22%), Positives = 78/163 (47%), Gaps = 22/163 (13%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVK 138
++ +++ SGD ++++W T+ ++ H + + + + ++LVVSGS D T++
Sbjct: 359 DDKYIVSASGDRTIKVWSTSTCEF-VRTLNGHKRGIACLQYR----DRLVVSGSSDNTIR 413
Query: 139 LWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAA---------- 188
LWD G L GHE ++ + S + D +++WD++AA
Sbjct: 414 LWDIECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWDLQAALDPRAPASTL 470
Query: 189 GVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNV 231
+R ++ H + +++E +++ + D ++ WD NV
Sbjct: 471 CLRTLV-EHSGRVFR---LQFDEFQIISSSHDDTILIWDFLNV 509
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 84.0 bits (206), Expect = 2e-16
Identities = 67/244 (27%), Positives = 115/244 (47%), Gaps = 8/244 (3%)
Query: 73 VTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGS 132
V +S N E L + S D +++W + H + V WS L+VS S
Sbjct: 51 VKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSD--SNLLVSAS 106
Query: 133 WDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRI 192
D+T+K+WD + GK L T +GH + ++ ++P S S D+++RIWDVK
Sbjct: 107 DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 193 VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSP 252
+PAH + + + + + +L+V+ + D R WD + + + + VKFSP
Sbjct: 166 TLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 253 FHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTC-GLDFSLQSPTQVADCSWDETI 311
+LA+ + D T++ W++SK L H E C +FS+ + S D +
Sbjct: 225 NGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 312 KIYD 315
I++
Sbjct: 284 YIWN 287
Score = 50.4 bits (119), Expect = 2e-06
Identities = 38/123 (30%), Positives = 65/123 (52%), Gaps = 8/123 (6%)
Query: 65 DWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSV--DWSQT 122
D N + V +S N +++L + D +L+LWD +K L+ Y H E Y + ++S T
Sbjct: 212 DDNPPVSFVKFSPNGKYIL-AATLDNTLKLWDYSKGKC-LKTYTGHKNEKYCIFANFSVT 269
Query: 123 RGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASAS--GDQTL 180
G+ +VSGS D V +W+ + + +GH ++ ST P ASA+ D+T+
Sbjct: 270 GGKW-IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP-TENIIASAALENDKTI 327
Query: 181 RIW 183
++W
Sbjct: 328 KLW 330
Score = 37.4 bits (85), Expect = 0.018
Identities = 28/80 (35%), Positives = 41/80 (51%), Gaps = 3/80 (3%)
Query: 236 FELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFS 295
F L GHT A+ VKFSP + LAS S D ++ W + +T+ H + +S
Sbjct: 39 FTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWG-AYDGKFEKTISGHKLGISDVAWS 96
Query: 296 LQSPTQVADCSWDETIKIYD 315
S V+ S D+T+KI+D
Sbjct: 97 SDSNLLVS-ASDDKTLKIWD 115
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 84.0 bits (206), Expect = 2e-16
Identities = 67/244 (27%), Positives = 115/244 (47%), Gaps = 8/244 (3%)
Query: 73 VTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGS 132
V +S N E L + S D +++W + H + V WS L+VS S
Sbjct: 51 VKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSD--SNLLVSAS 106
Query: 133 WDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRI 192
D+T+K+WD + GK L T +GH + ++ ++P S S D+++RIWDVK
Sbjct: 107 DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 193 VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSP 252
+PAH + + + + + +L+V+ + D R WD + + + + VKFSP
Sbjct: 166 TLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
Query: 253 FHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTC-GLDFSLQSPTQVADCSWDETI 311
+LA+ + D T++ W++SK L H E C +FS+ + S D +
Sbjct: 225 NGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 312 KIYD 315
I++
Sbjct: 284 YIWN 287
Score = 50.4 bits (119), Expect = 2e-06
Identities = 38/123 (30%), Positives = 65/123 (52%), Gaps = 8/123 (6%)
Query: 65 DWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSV--DWSQT 122
D N + V +S N +++L + D +L+LWD +K L+ Y H E Y + ++S T
Sbjct: 212 DDNPPVSFVKFSPNGKYIL-AATLDNTLKLWDYSKGKC-LKTYTGHKNEKYCIFANFSVT 269
Query: 123 RGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASAS--GDQTL 180
G+ +VSGS D V +W+ + + +GH ++ ST P ASA+ D+T+
Sbjct: 270 GGKW-IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP-TENIIASAALENDKTI 327
Query: 181 RIW 183
++W
Sbjct: 328 KLW 330
Score = 37.4 bits (85), Expect = 0.018
Identities = 28/80 (35%), Positives = 41/80 (51%), Gaps = 3/80 (3%)
Query: 236 FELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFS 295
F L GHT A+ VKFSP + LAS S D ++ W + +T+ H + +S
Sbjct: 39 FTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWG-AYDGKFEKTISGHKLGISDVAWS 96
Query: 296 LQSPTQVADCSWDETIKIYD 315
S V+ S D+T+KI+D
Sbjct: 97 SDSNLLVS-ASDDKTLKIWD 115
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 82.4 bits (202), Expect = 5e-16
Identities = 62/234 (26%), Positives = 111/234 (47%), Gaps = 21/234 (8%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
+++ S D +L++W +A L+ H V WS + +++SGS D+T+K+W+
Sbjct: 276 IVSGSDDNTLKVW-SAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNA 330
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHI-PGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEI 201
G+ + T GH ST+ H+ S S D TLR+WD++ V+ H A +
Sbjct: 331 ETGECIHTLYGHT----STVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 386
Query: 202 LSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASC 261
+Y+ +V+GA D ++ WD + L GHT + ++F H + S
Sbjct: 387 RC---VQYDGRRVVSGAYDFMVKVWD-PETETCLHTLQGHTNRVYSLQFDGIH---VVSG 439
Query: 262 SYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
S D ++R W+ + + + T+ H T G++ + + D T+KI+D
Sbjct: 440 SLDTSIRVWDV-ETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADSTVKIWD 489
Score = 62.0 bits (149), Expect = 7e-10
Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 8/141 (5%)
Query: 89 DGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSL 148
D +++WD + L + H VYS+ + VVSGS D ++++WD G +
Sbjct: 402 DFMVKVWDP-ETETCLHTLQGHTNRVYSLQFDGIH----VVSGSLDTSIRVWDVETGNCI 456
Query: 149 CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCK 208
T GH+S+ +I S + D T++IWD+K + + +
Sbjct: 457 HTLTGHQSLTSGMELKDNI---LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQ 513
Query: 209 YNENLLVTGAVDCSLRGWDLR 229
+N+N ++T + D +++ WDL+
Sbjct: 514 FNKNFVITSSDDGTVKLWDLK 534
Score = 42.0 bits (97), Expect = 7e-04
Identities = 27/107 (25%), Positives = 55/107 (51%), Gaps = 11/107 (10%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
+++ S D S+++WD + + H ++ + ++VSG+ D TVK+WD
Sbjct: 436 VVSGSLDTSIRVWDV-ETGNCIHTLTGHQSLTSGMELK----DNILVSGNADSTVKIWDI 490
Query: 143 TVGKSLCTFRG---HESIIYSTIWSPHIPGCFASASGDQTLRIWDVK 186
G+ L T +G H+S + ++ + ++S D T+++WD+K
Sbjct: 491 KTGQCLQTLQGPNKHQSAVTCLQFNKNF---VITSSDDGTVKLWDLK 534
Score = 35.8 bits (81), Expect = 0.053
Identities = 20/72 (27%), Positives = 39/72 (54%), Gaps = 6/72 (8%)
Query: 77 ENNEHVLITCSGDGSLQLWD--TAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWD 134
E +++L++ + D ++++WD T + LQ +H V + +++ V++ S D
Sbjct: 470 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDD 525
Query: 135 QTVKLWDPTVGK 146
TVKLWD G+
Sbjct: 526 GTVKLWDLKTGE 537
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 82.4 bits (202), Expect = 5e-16
Identities = 62/234 (26%), Positives = 111/234 (47%), Gaps = 21/234 (8%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
+++ S D +L++W +A L+ H V WS + +++SGS D+T+K+W+
Sbjct: 394 IVSGSDDNTLKVW-SAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNA 448
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHI-PGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEI 201
G+ + T GH ST+ H+ S S D TLR+WD++ V+ H A +
Sbjct: 449 ETGECIHTLYGHT----STVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
Query: 202 LSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASC 261
+Y+ +V+GA D ++ WD + L GHT + ++F H + S
Sbjct: 505 RC---VQYDGRRVVSGAYDFMVKVWD-PETETCLHTLQGHTNRVYSLQFDGIH---VVSG 557
Query: 262 SYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
S D ++R W+ + + + T+ H T G++ + + D T+KI+D
Sbjct: 558 SLDTSIRVWDV-ETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADSTVKIWD 607
Score = 62.0 bits (149), Expect = 7e-10
Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 8/141 (5%)
Query: 89 DGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSL 148
D +++WD + L + H VYS+ + VVSGS D ++++WD G +
Sbjct: 520 DFMVKVWDP-ETETCLHTLQGHTNRVYSLQFDGIH----VVSGSLDTSIRVWDVETGNCI 574
Query: 149 CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCK 208
T GH+S+ +I S + D T++IWD+K + + +
Sbjct: 575 HTLTGHQSLTSGMELKDNI---LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQ 631
Query: 209 YNENLLVTGAVDCSLRGWDLR 229
+N+N ++T + D +++ WDL+
Sbjct: 632 FNKNFVITSSDDGTVKLWDLK 652
Score = 42.0 bits (97), Expect = 7e-04
Identities = 27/107 (25%), Positives = 55/107 (51%), Gaps = 11/107 (10%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
+++ S D S+++WD + + H ++ + ++VSG+ D TVK+WD
Sbjct: 554 VVSGSLDTSIRVWDV-ETGNCIHTLTGHQSLTSGMELK----DNILVSGNADSTVKIWDI 608
Query: 143 TVGKSLCTFRG---HESIIYSTIWSPHIPGCFASASGDQTLRIWDVK 186
G+ L T +G H+S + ++ + ++S D T+++WD+K
Sbjct: 609 KTGQCLQTLQGPNKHQSAVTCLQFNKNF---VITSSDDGTVKLWDLK 652
Score = 35.8 bits (81), Expect = 0.053
Identities = 20/72 (27%), Positives = 39/72 (54%), Gaps = 6/72 (8%)
Query: 77 ENNEHVLITCSGDGSLQLWD--TAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWD 134
E +++L++ + D ++++WD T + LQ +H V + +++ V++ S D
Sbjct: 588 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDD 643
Query: 135 QTVKLWDPTVGK 146
TVKLWD G+
Sbjct: 644 GTVKLWDLKTGE 655
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 82.4 bits (202), Expect = 5e-16
Identities = 62/234 (26%), Positives = 111/234 (47%), Gaps = 21/234 (8%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
+++ S D +L++W +A L+ H V WS + +++SGS D+T+K+W+
Sbjct: 314 IVSGSDDNTLKVW-SAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNA 368
Query: 143 TVGKSLCTFRGHESIIYSTIWSPHI-PGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEI 201
G+ + T GH ST+ H+ S S D TLR+WD++ V+ H A +
Sbjct: 369 ETGECIHTLYGHT----STVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 424
Query: 202 LSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASC 261
+Y+ +V+GA D ++ WD + L GHT + ++F H + S
Sbjct: 425 RC---VQYDGRRVVSGAYDFMVKVWD-PETETCLHTLQGHTNRVYSLQFDGIH---VVSG 477
Query: 262 SYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
S D ++R W+ + + + T+ H T G++ + + D T+KI+D
Sbjct: 478 SLDTSIRVWDV-ETGNCIHTLTGHQSLTSGMEL---KDNILVSGNADSTVKIWD 527
Score = 62.0 bits (149), Expect = 7e-10
Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 8/141 (5%)
Query: 89 DGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSL 148
D +++WD + L + H VYS+ + VVSGS D ++++WD G +
Sbjct: 440 DFMVKVWDP-ETETCLHTLQGHTNRVYSLQFDGIH----VVSGSLDTSIRVWDVETGNCI 494
Query: 149 CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCK 208
T GH+S+ +I S + D T++IWD+K + + +
Sbjct: 495 HTLTGHQSLTSGMELKDNI---LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQ 551
Query: 209 YNENLLVTGAVDCSLRGWDLR 229
+N+N ++T + D +++ WDL+
Sbjct: 552 FNKNFVITSSDDGTVKLWDLK 572
Score = 42.0 bits (97), Expect = 7e-04
Identities = 27/107 (25%), Positives = 55/107 (51%), Gaps = 11/107 (10%)
Query: 83 LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDP 142
+++ S D S+++WD + + H ++ + ++VSG+ D TVK+WD
Sbjct: 474 VVSGSLDTSIRVWDV-ETGNCIHTLTGHQSLTSGMELK----DNILVSGNADSTVKIWDI 528
Query: 143 TVGKSLCTFRG---HESIIYSTIWSPHIPGCFASASGDQTLRIWDVK 186
G+ L T +G H+S + ++ + ++S D T+++WD+K
Sbjct: 529 KTGQCLQTLQGPNKHQSAVTCLQFNKNF---VITSSDDGTVKLWDLK 572
Score = 35.8 bits (81), Expect = 0.053
Identities = 20/72 (27%), Positives = 39/72 (54%), Gaps = 6/72 (8%)
Query: 77 ENNEHVLITCSGDGSLQLWD--TAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWD 134
E +++L++ + D ++++WD T + LQ +H V + +++ V++ S D
Sbjct: 508 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDD 563
Query: 135 QTVKLWDPTVGK 146
TVKLWD G+
Sbjct: 564 GTVKLWDLKTGE 575
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 81.6 bits (200), Expect = 8e-16
Identities = 55/204 (26%), Positives = 100/204 (49%), Gaps = 23/204 (11%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPL--QVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQT 136
N +++TCS D S+ +WD A +V H V VD+ ++ +VS S D+T
Sbjct: 356 NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFD----DKYIVSASGDRT 411
Query: 137 VKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPA 196
+K+W+ + + + T GH+ I + + S S D T+R+WD++ V+
Sbjct: 412 IKVWNTSTCEFVRTLNGHKRGIACLQYRDRL---VVSGSSDNTIRLWDIECGACLRVLEG 468
Query: 197 HQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQP--------VFELLGHTYAIRRV 248
H+ E++ C +++ +V+GA D ++ WDL P + L+ H+ + R+
Sbjct: 469 HE-ELVRC--IRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 525
Query: 249 KFSPFHASVLASCSYDFTVRFWNF 272
+F F + S S+D T+ W+F
Sbjct: 526 QFDEFQ---IVSSSHDDTILIWDF 546
Score = 66.6 bits (161), Expect = 3e-11
Identities = 53/212 (25%), Positives = 91/212 (42%), Gaps = 19/212 (8%)
Query: 109 EHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIP 168
E ++ VY + + +Q +VSG D T+K+WD + GH + + +
Sbjct: 265 ETSKGVYCLQYD----DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV- 319
Query: 169 GCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDL 228
+ S D T+R+WDV + + H +L ++N ++VT + D S+ WD+
Sbjct: 320 --IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH---LRFNNGMMVTCSKDRSIAVWDM 374
Query: 229 RNVRQPVFE--LLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHT 286
+ L+GH A+ V F + S S D T++ WN S + + T+ H
Sbjct: 375 ASPTDITLRRVLVGHRAAVNVVDFDD---KYIVSASGDRTIKVWNTSTCE-FVRTLNGHK 430
Query: 287 EFTCGLDFSLQSPTQVADCSWDETIKIYDPAC 318
L + V S D TI+++D C
Sbjct: 431 RGIACLQY---RDRLVVSGSSDNTIRLWDIEC 459
Score = 58.9 bits (141), Expect = 6e-09
Identities = 51/231 (22%), Positives = 112/231 (48%), Gaps = 24/231 (10%)
Query: 89 DGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSL 148
D ++++WD ++ H V + + E+++++GS D TV++WD G+ L
Sbjct: 286 DNTIKIWDK-NTLECKRILTGHTGSVLCLQYD----ERVIITGSSDSTVRVWDVNTGEML 340
Query: 149 CTFRGH-ESIIYSTIWSPHIPGCFASASGDQTLRIWDVKA---AGVRIVIPAHQAEILSC 204
T H E++++ + G + S D+++ +WD+ + +R V+ H+A +
Sbjct: 341 NTLIHHCEAVLHLRFNN----GMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
Query: 205 DWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYD 264
D +++ +V+ + D +++ W+ + + V L GH R + + ++ S S D
Sbjct: 397 D---FDDKYIVSASGDRTIKVWN-TSTCEFVRTLNGHK---RGIACLQYRDRLVVSGSSD 449
Query: 265 FTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
T+R W+ + + L +E H E + F + ++ ++D IK++D
Sbjct: 450 NTIRLWDI-ECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWD 496
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 81.6 bits (200), Expect = 8e-16
Identities = 55/204 (26%), Positives = 100/204 (49%), Gaps = 23/204 (11%)
Query: 79 NEHVLITCSGDGSLQLWDTAKAAGPL--QVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQT 136
N +++TCS D S+ +WD A +V H V VD+ ++ +VS S D+T
Sbjct: 392 NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFD----DKYIVSASGDRT 447
Query: 137 VKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPA 196
+K+W+ + + + T GH+ I + + S S D T+R+WD++ V+
Sbjct: 448 IKVWNTSTCEFVRTLNGHKRGIACLQYRDRL---VVSGSSDNTIRLWDIECGACLRVLEG 504
Query: 197 HQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQP--------VFELLGHTYAIRRV 248
H+ E++ C +++ +V+GA D ++ WDL P + L+ H+ + R+
Sbjct: 505 HE-ELVRC--IRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 561
Query: 249 KFSPFHASVLASCSYDFTVRFWNF 272
+F F + S S+D T+ W+F
Sbjct: 562 QFDEFQ---IVSSSHDDTILIWDF 582
Score = 66.6 bits (161), Expect = 3e-11
Identities = 53/212 (25%), Positives = 91/212 (42%), Gaps = 19/212 (8%)
Query: 109 EHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIP 168
E ++ VY + + +Q +VSG D T+K+WD + GH + + +
Sbjct: 301 ETSKGVYCLQYD----DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV- 355
Query: 169 GCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDL 228
+ S D T+R+WDV + + H +L ++N ++VT + D S+ WD+
Sbjct: 356 --IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH---LRFNNGMMVTCSKDRSIAVWDM 410
Query: 229 RNVRQPVFE--LLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHT 286
+ L+GH A+ V F + S S D T++ WN S + + T+ H
Sbjct: 411 ASPTDITLRRVLVGHRAAVNVVDFDD---KYIVSASGDRTIKVWNTSTCE-FVRTLNGHK 466
Query: 287 EFTCGLDFSLQSPTQVADCSWDETIKIYDPAC 318
L + V S D TI+++D C
Sbjct: 467 RGIACLQY---RDRLVVSGSSDNTIRLWDIEC 495
Score = 58.9 bits (141), Expect = 6e-09
Identities = 51/231 (22%), Positives = 112/231 (48%), Gaps = 24/231 (10%)
Query: 89 DGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSL 148
D ++++WD ++ H V + + E+++++GS D TV++WD G+ L
Sbjct: 322 DNTIKIWDK-NTLECKRILTGHTGSVLCLQYD----ERVIITGSSDSTVRVWDVNTGEML 376
Query: 149 CTFRGH-ESIIYSTIWSPHIPGCFASASGDQTLRIWDVKA---AGVRIVIPAHQAEILSC 204
T H E++++ + G + S D+++ +WD+ + +R V+ H+A +
Sbjct: 377 NTLIHHCEAVLHLRFNN----GMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
Query: 205 DWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYD 264
D +++ +V+ + D +++ W+ + + V L GH R + + ++ S S D
Sbjct: 433 D---FDDKYIVSASGDRTIKVWN-TSTCEFVRTLNGHK---RGIACLQYRDRLVVSGSSD 485
Query: 265 FTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
T+R W+ + + L +E H E + F + ++ ++D IK++D
Sbjct: 486 NTIRLWDI-ECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWD 532
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 81.6 bits (200), Expect = 8e-16
Identities = 67/234 (28%), Positives = 103/234 (44%), Gaps = 33/234 (14%)
Query: 73 VTWSENNEHVLITCSGDGSLQLW--DTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVS 130
V W+ + ++L TCS D S+ +W D + V H Q+V V W + ++L+ S
Sbjct: 111 VAWAPSG-NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPS--QELLAS 167
Query: 131 GSWDQTVKLWDPTVGKSLC--TFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAA 188
S+D TVKL+ +C T GHES ++S + P AS S D+T+RIW
Sbjct: 168 ASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLP 226
Query: 189 G----------------VRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDL---R 229
G + + H I WC+ L T D ++R +
Sbjct: 227 GNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLT-GALATACGDDAIRVFQEDPNS 285
Query: 230 NVRQPVFELLGHTYA-----IRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSL 278
+ +QP F L H + + V ++P +LASCS D V FW + +P+ L
Sbjct: 286 DPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL 339
Score = 56.2 bits (134), Expect = 4e-08
Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 51/238 (21%)
Query: 82 VLITCSGDGSLQLWDTAKAAGPLQ--VYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKL 139
+L +C GD +++W T + + + + H + V V WS + S S+D T +
Sbjct: 30 LLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGN--YLASASFDATTCI 87
Query: 140 WDPTVGKSLC--TFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAH 197
W C T GHE+ + S W+P A+ S D+++ +W+V
Sbjct: 88 WKKNQDDFECVTTLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEV------------ 134
Query: 198 QAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASV 257
D + + V L HT ++ V + P +
Sbjct: 135 -----------------------------DEEDEYECVSVLNSHTQDVKHVVWHP-SQEL 164
Query: 258 LASCSYDFTVRFWNFSKPDSL-LETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIY 314
LAS SYD TV+ + + D + T+E H L F S ++A CS D T++I+
Sbjct: 165 LASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFD-PSGQRLASCSDDRTVRIW 221
Score = 47.4 bits (111), Expect = 2e-05
Identities = 41/158 (25%), Positives = 71/158 (44%), Gaps = 10/158 (6%)
Query: 163 WSPHIPGCFASASGDQTLRIWDVKAAG---VRIVIPAHQAEILSCDWCKYNENLLVTGAV 219
W+P AS GD+ +RIW + ++ HQ + W N L + +
Sbjct: 24 WNP-AGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCG-NYLASASF 81
Query: 220 DCSLRGWDL-RNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSL 278
D + W ++ + V L GH ++ V ++P ++LA+CS D +V W + D
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAP-SGNLLATCSRDKSVWVWEVDEEDEY 140
Query: 279 LETVEHHTEFTCGLDFSLQSPTQ--VADCSWDETIKIY 314
E V T + + P+Q +A S+D+T+K+Y
Sbjct: 141 -ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 81.6 bits (200), Expect = 8e-16
Identities = 66/268 (24%), Positives = 123/268 (45%), Gaps = 33/268 (12%)
Query: 70 LFDVTWSENNEHVLITCSGDGSLQLWDTAK--AAGPLQVYKEHA-----------QEVYS 116
+F W+ ++ +L + SGD + ++W+ ++ +G Q+ H ++V S
Sbjct: 172 VFICAWNPVSD-LLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTS 230
Query: 117 VDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASG 176
+DW+ L+ +GS+D ++W G T H+ I++ W+ G F ++G
Sbjct: 231 LDWNSEG--TLLATGSYDGFARIWTKD-GNLASTLGQHKGPIFALKWNKK--GNFILSAG 285
Query: 177 -DQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPV 235
D+T IWD + P H A L DW + N + + D + L R P+
Sbjct: 286 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--QSNNTFASCSTDMCIHVCKLGQDR-PI 342
Query: 236 FELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFS 295
GHT + +K+ P ++LASCS D T++ W+ K D+ + ++ H + + +S
Sbjct: 343 KTFQGHTNEVNAIKWDPT-GNLLASCSDDMTLKIWSM-KQDNCVHDLQAHNKEIYTIKWS 400
Query: 296 LQSP--------TQVADCSWDETIKIYD 315
P +A S+D T++++D
Sbjct: 401 PTGPGTNNPNANLMLASASFDSTVRLWD 428
Score = 67.4 bits (163), Expect = 2e-11
Identities = 58/211 (27%), Positives = 90/211 (42%), Gaps = 18/211 (8%)
Query: 70 LFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVV 129
+F + W++ +L + D + +WD A Q + H+ VDW +
Sbjct: 269 IFALKWNKKGNFIL-SAGVDKTTIIWD-AHTGEAKQQFPFHSAPALDVDW---QSNNTFA 323
Query: 130 SGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAG 189
S S D + + + + TF+GH + + + W P AS S D TL+IW +K
Sbjct: 324 SCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDP-TGNLLASCSDDMTLKIWSMKQDN 382
Query: 190 VRIVIPAHQAEILSCDWC-------KYNENLLVTGA-VDCSLRGWDL-RNVRQPVFELLG 240
+ AH EI + W N NL++ A D ++R WD+ R + + L
Sbjct: 383 CVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGI--CIHTLTK 440
Query: 241 HTYAIRRVKFSPFHASVLASCSYDFTVRFWN 271
H + V FSP LAS S+D V WN
Sbjct: 441 HQEPVYSVAFSP-DGRYLASGSFDKCVHIWN 470
Score = 59.3 bits (142), Expect = 4e-09
Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 9/117 (7%)
Query: 81 HVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQT-------RGEQLVVSGSW 133
++L +CS D +L++W + K + + H +E+Y++ WS T ++ S S+
Sbjct: 362 NLLASCSDDMTLKIW-SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASF 420
Query: 134 DQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGV 190
D TV+LWD G + T H+ +YS +SP AS S D+ + IW+ + +
Sbjct: 421 DSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPD-GRYLASGSFDKCVHIWNTQTGAL 476
Score = 48.5 bits (114), Expect = 8e-06
Identities = 47/177 (26%), Positives = 71/177 (40%), Gaps = 24/177 (13%)
Query: 152 RGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV---KAAGVRIVIPAH----------- 197
RGHES ++ W+P + AS SGD T RIW++ +G ++ H
Sbjct: 166 RGHESEVFICAWNP-VSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 198 QAEILSCDWCKYNENLLVTGAVDCSLRGWDL-RNVRQPVFELLGHTYAIRRVKFSPFHAS 256
++ S DW LL TG+ D R W N+ + + G +A++ K F
Sbjct: 225 NKDVTSLDW-NSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNF--- 280
Query: 257 VLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKI 313
+ S D T W+ ++ + H LD QS A CS D I +
Sbjct: 281 -ILSAGVDKTTIIWDAHTGEAKQQFPFHSAP---ALDVDWQSNNTFASCSTDMCIHV 333
Score = 42.0 bits (97), Expect = 7e-04
Identities = 33/128 (25%), Positives = 62/128 (48%), Gaps = 13/128 (10%)
Query: 67 NDGLFDVTWSE--------NNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVD 118
N ++ + WS N +L + S D +++LWD + + +H + VYSV
Sbjct: 391 NKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGIC-IHTLTKHQEPVYSVA 449
Query: 119 WSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQ 178
+S + + SGS+D+ V +W+ G + ++RG I+ W+ ASAS D
Sbjct: 450 FSPDG--RYLASGSFDKCVHIWNTQTGALVHSYRGTGG-IFEVCWNAAGDKVGASAS-DG 505
Query: 179 TLRIWDVK 186
++ + D++
Sbjct: 506 SVCVLDLR 513
Score = 30.0 bits (66), Expect = 2.9
Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 15/106 (14%)
Query: 192 IVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRR---- 247
+V+ H++E+ C W ++ LL +G+ D + R W+L L + IR
Sbjct: 163 VVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQD 221
Query: 248 ------VKFSPFHA--SVLASCSYDFTVRFWNFSKPDSLLETVEHH 285
V +++ ++LA+ SYD R W +K +L T+ H
Sbjct: 222 VPSNKDVTSLDWNSEGTLLATGSYDGFARIW--TKDGNLASTLGQH 265
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 80.1 bits (196), Expect = 2e-15
Identities = 65/218 (29%), Positives = 108/218 (49%), Gaps = 9/218 (4%)
Query: 99 KAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESII 158
K A LQ HA V S+ + G +L+ +G D V LW + + GH S +
Sbjct: 8 KTAWKLQEIVAHASNVSSLVLGKASG-RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV 66
Query: 159 YST-IWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTG 217
S + +P S SG ++R+WD++AA + + H+A I S D+ Y E + +G
Sbjct: 67 ESVRLNTPEELIVAGSQSG--SIRVWDLEAAKILRTLMGHKANICSLDFHPYGE-FVASG 123
Query: 218 AVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDS 277
+ D +++ WD+R + VF GH+ A+R ++FSP LAS + D TV+ W+ +
Sbjct: 124 SQDTNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTVKLWDLT-AGK 180
Query: 278 LLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
++ HT ++F + +A S D TI+ +D
Sbjct: 181 MMSEFPGHTGPVNVVEFH-PNEYLLASGSSDRTIRFWD 217
Score = 79.7 bits (195), Expect = 3e-15
Identities = 58/191 (30%), Positives = 92/191 (48%), Gaps = 6/191 (3%)
Query: 80 EHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKL 139
E +++ S GS+++WD +AA L+ H + S+D+ GE V SGS D +KL
Sbjct: 75 EELIVAGSQSGSIRVWD-LEAAKILRTLMGHKANICSLDF-HPYGE-FVASGSQDTNIKL 131
Query: 140 WDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQA 199
WD + +RGH + +SP ASA+ D T+++WD+ A + P H
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPD-GKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190
Query: 200 EILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLA 259
+ ++ NE LL +G+ D ++R WDL Q V + G +R V F+P + +
Sbjct: 191 PVNVVEF-HPNEYLLASGSSDRTIRFWDLEKF-QVVSCIEGEPGPVRSVLFNPDGCCLYS 248
Query: 260 SCSYDFTVRFW 270
C V W
Sbjct: 249 GCQDSLRVYGW 259
Score = 73.2 bits (178), Expect = 3e-13
Identities = 59/194 (30%), Positives = 95/194 (48%), Gaps = 9/194 (4%)
Query: 82 VLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD 141
+L T D + LW K + H V SV + E+L+V+GS ++++WD
Sbjct: 35 LLATGGDDCRVNLWSINKP-NCIMSLTGHTSPVESVRLNTP--EELIVAGSQSGSIRVWD 91
Query: 142 PTVGKSLCTFRGHESIIYSTIWSPHIPGCF-ASASGDQTLRIWDVKAAGVRIVIPAHQAE 200
K L T GH++ I S + P+ G F AS S D +++WD++ G H ++
Sbjct: 92 LEAAKILRTLMGHKANICSLDFHPY--GEFVASGSQDTNIKLWDIRRKGCVFRYRGH-SQ 148
Query: 201 ILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLAS 260
+ C + L + A D +++ WDL + + E GHT + V+F P + +LAS
Sbjct: 149 AVRCLRFSPDGKWLASAADDHTVKLWDL-TAGKMMSEFPGHTGPVNVVEFHP-NEYLLAS 206
Query: 261 CSYDFTVRFWNFSK 274
S D T+RFW+ K
Sbjct: 207 GSSDRTIRFWDLEK 220
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 80.1 bits (196), Expect = 2e-15
Identities = 69/250 (27%), Positives = 110/250 (44%), Gaps = 17/250 (6%)
Query: 32 LACATAQHYGIAGCGTL--------LILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVL 83
+ACA A CG L L D +E +S + N++ +
Sbjct: 109 MACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQI 168
Query: 84 ITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPT 143
+T SGDG+ LWD ++ LQ + H +V +D + + VSG D+ +WD
Sbjct: 169 LTASGDGTCALWDV-ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 227
Query: 144 VGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILS 203
G+ + F HES I S + P FAS S D T R++D++ A + I + ++ I
Sbjct: 228 SGQCVQAFETHESDINSVRYYPS-GDAFASGSDDATCRLYDLR-ADREVAIYSKESIIFG 285
Query: 204 CDWCKY--NENLLVTGAVDCSLRGWD-LRNVRQPVFELLGHTYAIRRVKFSPFHASVLAS 260
+ + LL G D ++ WD L+ R + L GH + ++ SP + S
Sbjct: 286 ASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSI--LFGHENRVSTLRVSP-DGTAFCS 342
Query: 261 CSYDFTVRFW 270
S+D T+R W
Sbjct: 343 GSWDHTLRVW 352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,366,304
Number of Sequences: 37866
Number of extensions: 568914
Number of successful extensions: 3295
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 1235
Number of HSP's gapped (non-prelim): 1120
length of query: 323
length of database: 18,247,518
effective HSP length: 102
effective length of query: 221
effective length of database: 14,385,186
effective search space: 3179126106
effective search space used: 3179126106
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.