Search of human proteins with 4503549

Search of human proteins with 4503549

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503549 neutrophil elastase preproprotein [Homo sapiens]
         (267 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503549 neutrophil elastase preproprotein [Homo sapiens]           544   e-155
gi|71361688 myeloblastin [Homo sapiens]                               271   3e-73
gi|11342670 azurocidin 1 preproprotein [Homo sapiens]                 199   3e-51
gi|47551347 protease, serine-like 1 [Homo sapiens]                    157   1e-38
gi|58331209 chymotrypsin-like elastase family, member 1 [Homo sa...   139   3e-33
gi|4503149 cathepsin G preproprotein [Homo sapiens]                   137   7e-33
gi|4885369 granzyme M precursor [Homo sapiens]                        137   7e-33
gi|5453676 granzyme A precursor [Homo sapiens]                        135   4e-32
gi|42544239 complement factor D preproprotein [Homo sapiens]          133   1e-31
gi|221625528 granzyme B precursor [Homo sapiens]                      125   5e-29
gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprot...   125   5e-29
gi|15559207 elastase 2A preproprotein [Homo sapiens]                  124   1e-28
gi|62526043 chymotrypsin C preproprotein [Homo sapiens]               120   1e-27
gi|15529990 granzyme H [Homo sapiens]                                 120   1e-27
gi|4505881 plasminogen [Homo sapiens]                                 120   2e-27
gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]               118   6e-27
gi|6679625 elastase 3B, pancreatic preproprotein [Homo sapiens]       117   8e-27
gi|236460050 elastase 3A, pancreatic preproprotein [Homo sapiens]     117   1e-26
gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo s...   117   1e-26
gi|58331211 elastase 2B preproprotein [Homo sapiens]                  115   5e-26
gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]          114   1e-25
gi|110815798 ovochymase 1 [Homo sapiens]                              114   1e-25
gi|4502173 prostate specific antigen isoform 1 preproprotein [Ho...   113   2e-25
gi|4504235 granzyme K precursor [Homo sapiens]                        113   2e-25
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]           105   3e-23
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          105   3e-23
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]       104   9e-23
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]        104   9e-23
gi|58218970 protease, serine, 36 [Homo sapiens]                       103   1e-22
gi|4503137 chymotrypsin-like [Homo sapiens]                           103   1e-22

>gi|4503549 neutrophil elastase preproprotein [Homo sapiens]
          Length = 267

 Score =  544 bits (1401), Expect = e-155
 Identities = 267/267 (100%), Positives = 267/267 (100%)

Query: 1   MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI 60
           MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
Sbjct: 1   MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI 60

Query: 61  APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI 120
           APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
Sbjct: 61  APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI 120

Query: 121 LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL 180
           LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
Sbjct: 121 LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL 180

Query: 181 CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN 240
           CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
Sbjct: 181 CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN 240

Query: 241 WIDSIIQRSEDNPCPHPRDPDPASRTH 267
           WIDSIIQRSEDNPCPHPRDPDPASRTH
Sbjct: 241 WIDSIIQRSEDNPCPHPRDPDPASRTH 267


>gi|71361688 myeloblastin [Homo sapiens]
          Length = 256

 Score =  271 bits (694), Expect = 3e-73
 Identities = 134/242 (55%), Positives = 176/242 (72%), Gaps = 3/242 (1%)

Query: 12  LACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGG---HFCGATLIAPNFVMSA 68
           LA VL ALLL G A A+EIVGG  A+PH+ P+M SLQ+RG    HFCG TLI P+FV++A
Sbjct: 10  LASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTA 69

Query: 69  AHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSAT 128
           AHC+ ++  R V VVLGAHN+  +EPT+Q F+V ++F N YD  N LND++++QL+  A 
Sbjct: 70  AHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPAN 129

Query: 129 INANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCT 188
           ++A+V   QLP Q + + +G QCLAMGWG +G +   A VLQELNVTVVT  CR  N+CT
Sbjct: 130 LSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICT 189

Query: 189 LVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQR 248
            V  R+AG+CFGDSG PL+C+G+I GI SFV  GCA+ L+PD F  VA +V+WI S ++R
Sbjct: 190 FVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRR 249

Query: 249 SE 250
            E
Sbjct: 250 VE 251


>gi|11342670 azurocidin 1 preproprotein [Homo sapiens]
          Length = 251

 Score =  199 bits (505), Expect = 3e-51
 Identities = 111/254 (43%), Positives = 150/254 (59%), Gaps = 8/254 (3%)

Query: 6   RLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFV 65
           RL  L L   L A    G++   +IVGGR+ARP  +PF+ S+Q +G HFCG  LI   FV
Sbjct: 3   RLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFV 62

Query: 66  MSAAHCVANVNVRAVRVVLGAHNLSRRE-PTRQVFAVQRIFENGYDPVNLLNDIVILQLN 124
           M+AA C  + N     VVLGA++L RRE  +RQ F++  + ENGYDP   LND+++LQL+
Sbjct: 63  MTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLD 122

Query: 125 GSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVV-TSLCRR 183
             A + ++V +  LP Q   +  G +C   GWG       ++   + +NVTV     CR 
Sbjct: 123 REANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCRP 182

Query: 184 SNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWID 243
           +NVCT V  R+ G+C GD G+PLVC GL HG+ASF  G C  G  PD F  VA F +WID
Sbjct: 183 NNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRG--PDFFTRVALFRDWID 240

Query: 244 SIIQRSEDNPCPHP 257
            ++    +NP P P
Sbjct: 241 GVL----NNPGPGP 250


>gi|47551347 protease, serine-like 1 [Homo sapiens]
          Length = 283

 Score =  157 bits (396), Expect = 1e-38
 Identities = 97/276 (35%), Positives = 136/276 (49%), Gaps = 23/276 (8%)

Query: 4   GRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPN 63
           GR L  +  A +LP     G+   ++I+GG    PH+ P+M S++  G H CG  L+   
Sbjct: 9   GRPLLTVATALMLPVKPPAGS-WGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRAR 67

Query: 64  FVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFEN-GYDPVNLLNDIVILQ 122
           +V+SAAHC ++ ++R   VVLGAH LS  EPT+QVF +  +  +  Y P+   NDI +L+
Sbjct: 68  WVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLR 127

Query: 123 LNGSATINANVQVAQLPAQGRRLGN-GVQCLAMGWGLLGRNRGIASVLQELNVTV----- 176
           LNGSA +   V + +LP +  R    G +C   GWG +     +   L E  V V     
Sbjct: 128 LNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDV 187

Query: 177 ----------VTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASG 226
                     +T LC RS         + G C  DSG PLVC    HG+ SF    C   
Sbjct: 188 CNSSWKGHLTLTMLCTRSG-----DSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDP 242

Query: 227 LYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDP 262
             PD +  V+ FV WI  +++RS   P P P    P
Sbjct: 243 KTPDVYTQVSAFVAWIWDVVRRSSPQPGPLPGTTRP 278


>gi|58331209 chymotrypsin-like elastase family, member 1 [Homo
           sapiens]
          Length = 258

 Score =  139 bits (349), Expect = 3e-33
 Identities = 93/242 (38%), Positives = 130/242 (53%), Gaps = 26/242 (10%)

Query: 28  SEIVGGRRARPHAWPFMVSLQLRGG----HFCGATLIAPNFVMSAAHCVANVNVRAVRVV 83
           + +VGG  A  ++WP  +SLQ R G    H CG TLI  N+VM+AAHCV     +  RVV
Sbjct: 17  ARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCVDYQ--KTFRVV 74

Query: 84  LGAHNLSRREPTRQVFAVQRIFENGY---DPVNLLNDIVILQLNGSATINANVQVAQLPA 140
            G HNLS+ + T Q  +VQ+I  + Y   D V    DI +L+L  S T+N+ VQ+  LP 
Sbjct: 75  AGDHNLSQNDGTEQYVSVQKIVVHPYWNSDNVAAGYDIALLRLAQSVTLNSYVQLGVLPQ 134

Query: 141 QGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNV-TVVTSLCRRSN----------VCTL 189
           +G  L N   C   GWG    N  +A  LQ+  + +V  ++C  S+          VC  
Sbjct: 135 EGAILANNSPCYITGWGKTKTNGQLAQTLQQAYLPSVDYAICSSSSYWGSTVKNTMVCAG 194

Query: 190 VRGRQAGVCFGDSGSPLVC--NG--LIHGIASFVRG-GCASGLYPDAFAPVAQFVNWIDS 244
             G ++G C GDSG PL C  NG   +HG+ SFV   GC     P  F  V+ +++WI++
Sbjct: 195 GDGVRSG-CQGDSGGPLHCLVNGKYSVHGVTSFVSSRGCNVSRKPTVFTQVSAYISWINN 253

Query: 245 II 246
           +I
Sbjct: 254 VI 255


>gi|4503149 cathepsin G preproprotein [Homo sapiens]
          Length = 255

 Score =  137 bits (346), Expect = 7e-33
 Identities = 90/242 (37%), Positives = 126/242 (52%), Gaps = 23/242 (9%)

Query: 15  VLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLR---GGHFCGATLIAPNFVMSAAHC 71
           +L A LL   A A EI+GGR +RPH+ P+M  LQ++   G   CG  L+  +FV++AAHC
Sbjct: 6   LLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHC 65

Query: 72  V-ANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENG-YDPVNLLNDIVILQLNGSATI 129
             +N+NV      LGAHN+ RRE T+Q    +R   +  Y+   + NDI++LQL+     
Sbjct: 66  WGSNINV-----TLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 120

Query: 130 NANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTV---------VTSL 180
           N NV    LP     L  G  C   GWG +   RG    L+E+ + V           S 
Sbjct: 121 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRG-TDTLREVQLRVQRDRQCLRIFGSY 179

Query: 181 CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN 240
             R  +C   R  +     GDSG PL+CN + HGI S+   G +SG+ P+ F  V+ F+ 
Sbjct: 180 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSY---GKSSGVPPEVFTRVSSFLP 236

Query: 241 WI 242
           WI
Sbjct: 237 WI 238


>gi|4885369 granzyme M precursor [Homo sapiens]
          Length = 257

 Score =  137 bits (346), Expect = 7e-33
 Identities = 87/257 (33%), Positives = 130/257 (50%), Gaps = 23/257 (8%)

Query: 13  ACVLPALLLG------GTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVM 66
           ACV   L+L       G++  ++I+GGR   PH+ P+M SLQ  G H CG  L+ P +V+
Sbjct: 3   ACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVL 62

Query: 67  SAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLL-NDIVILQLNG 125
           +AAHC+A   +  +R+VLG H L     T  + A   I    Y PV  L ND+ +LQL+G
Sbjct: 63  TAAHCLAQ-RMAQLRLVLGLHTLDSPGLTFHIKAA--IQHPRYKPVPALENDLALLQLDG 119

Query: 126 SATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVV-TSLCRRS 184
               +  ++   LP++ + +  G +C   GWGL  +   ++ VL+EL++ V+ T +C  S
Sbjct: 120 KVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNS 179

Query: 185 N----------VCTLVRGRQAGVCFGDSGSPLVC--NGLIHGIASFVRGGCASGLYPDAF 232
                      VC     +    C GDSG PLVC    ++ G+ SF    C     P   
Sbjct: 180 RFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVA 239

Query: 233 APVAQFVNWIDSIIQRS 249
             VA +V+WI  +  RS
Sbjct: 240 TAVAPYVSWIRKVTGRS 256


>gi|5453676 granzyme A precursor [Homo sapiens]
          Length = 262

 Score =  135 bits (340), Expect = 4e-32
 Identities = 86/246 (34%), Positives = 132/246 (53%), Gaps = 23/246 (9%)

Query: 15  VLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVAN 74
           V+ +LLL    +  +I+GG    PH+ P+MV L L     C   LIA ++V++AAHC  N
Sbjct: 14  VVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHC--N 71

Query: 75  VNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENG-YDPVNLLNDIVILQLNGSATINANV 133
           +N R+ +V+LGAH+++R EPT+Q+  V++ F    YDP     D+ +LQL   A IN  V
Sbjct: 72  LNKRS-QVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYV 130

Query: 134 QVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVV-TSLCRRSN------- 185
            +  LP +G  +  G  C   GWG    +   +  L+E+N+T++   +C   N       
Sbjct: 131 TILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPV 190

Query: 186 -----VC--TLVRGRQAGVCFGDSGSPLVCNGLIHGIASF-VRGGCASGLYPDAFAPVA- 236
                VC  +L  GR +  C GDSGSPL+C G+  G+ SF +   C     P  +  ++ 
Sbjct: 191 IGMNMVCAGSLRGGRDS--CNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSK 248

Query: 237 QFVNWI 242
           + +NWI
Sbjct: 249 KHLNWI 254


>gi|42544239 complement factor D preproprotein [Homo sapiens]
          Length = 253

 Score =  133 bits (335), Expect = 1e-31
 Identities = 81/244 (33%), Positives = 127/244 (52%), Gaps = 18/244 (7%)

Query: 19  LLLGGTALAS----EIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVAN 74
           +LLG  A A+     I+GGR A  HA P+M S+QL G H CG  L+A  +V+SAAHC+ +
Sbjct: 11  VLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLED 70

Query: 75  VNVRAVRVVLGAHNLSRREPTRQVFAVQRIFEN-GYDPVNLLNDIVILQLNGSATINANV 133
                V+V+LGAH+LS+ EP+++++ V R   +    P  + +D+++LQL+  AT+   V
Sbjct: 71  AADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAV 130

Query: 134 QVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVV-TSLCRRSN------- 185
           +        R +  G  C   GWG++         LQ + + V+  + C R         
Sbjct: 131 RPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAIT 190

Query: 186 ---VCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWI 242
              +C     R +  C GDSG PLVC G++ G+ +     C +   P  +  VA +  WI
Sbjct: 191 ERLMCAESNRRDS--CKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWI 248

Query: 243 DSII 246
           DS++
Sbjct: 249 DSVL 252


>gi|221625528 granzyme B precursor [Homo sapiens]
          Length = 247

 Score =  125 bits (313), Expect = 5e-29
 Identities = 87/248 (35%), Positives = 125/248 (50%), Gaps = 21/248 (8%)

Query: 15  VLPALLLGGTALASEIVGGRRARPHAWPFMVSLQL---RGGHFCGATLIAPNFVMSAAHC 71
           +L A LL   A A EI+GG  A+PH+ P+M  L +   +    CG  LI  +FV++AAHC
Sbjct: 6   LLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHC 65

Query: 72  VANVNVRAVRVVLGAHNLSRREPTRQVFAVQR-IFENGYDPVNLLNDIVILQLNGSATIN 130
             +    ++ V LGAHN+  +EPT+Q   V+R I    Y+P N  NDI++LQL   A   
Sbjct: 66  WGS----SINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRT 121

Query: 131 ANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSN----- 185
             VQ  +LP+   ++  G  C   GWG        +  LQE+ +TV       S+     
Sbjct: 122 RAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYY 181

Query: 186 -----VCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN 240
                +C      +     GDSG PLVCN +  GI S+ R    +G+ P A   V+ FV+
Sbjct: 182 DSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRN---NGMPPRACTKVSSFVH 238

Query: 241 WIDSIIQR 248
           WI   ++R
Sbjct: 239 WIKKTMKR 246


>gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprotein
           [Homo sapiens]
          Length = 256

 Score =  125 bits (313), Expect = 5e-29
 Identities = 82/255 (32%), Positives = 128/255 (50%), Gaps = 29/255 (11%)

Query: 18  ALLLGGTAL--ASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANV 75
           + LL  TA     +++ G    PH+ P+ V+L  RG   CGA+LI+P++V+SAAHC +  
Sbjct: 8   SFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQS-- 65

Query: 76  NVRAVRVVLGAHNLSRREPTRQVFAVQRIFENG-YDPVNLLNDIVILQLNGSATINANVQ 134
             R +RV LG HNL +R+   Q+    R+  +  Y+  +  NDI++L+L   A +N  V+
Sbjct: 66  --RFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVR 123

Query: 135 VAQLPAQGRRLGNGVQCLAMGWGLLGRNR-----------GIASVLQELNVTVVTSL-CR 182
            A LP +    G    C+  GWGL+  N             +   L   N+++++   C 
Sbjct: 124 PAVLPTRCPHPGEA--CVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCD 181

Query: 183 RSN--------VCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAP 234
           +S         VC    GR A  C GDSG PLVC G++ GI S+    C +   P  +  
Sbjct: 182 KSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTK 241

Query: 235 VAQFVNWIDSIIQRS 249
           V  ++ WI   ++R+
Sbjct: 242 VCHYLEWIRETMKRN 256


>gi|15559207 elastase 2A preproprotein [Homo sapiens]
          Length = 269

 Score =  124 bits (310), Expect = 1e-28
 Identities = 84/243 (34%), Positives = 121/243 (49%), Gaps = 27/243 (11%)

Query: 28  SEIVGGRRARPHAWPFMVSLQLRGG----HFCGATLIAPNFVMSAAHCVANVNVRAVRVV 83
           + +VGG  ARP++WP+ VSLQ        H CG +LIA ++V++AAHC+++   R  RV 
Sbjct: 27  TRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSS--RTYRVG 84

Query: 84  LGAHNLSRREPTRQVFAVQRIFEN---GYDPVNLLNDIVILQLNGSATINANVQVAQLPA 140
           LG HNL   E      +V +I  +     + ++  NDI +L+L    ++   +Q+A LP 
Sbjct: 85  LGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPP 144

Query: 141 QGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVT-----------SLCRRSNVCTL 189
            G  L N   C   GWG L  N  +  VLQ+  + VV            S  + S +C  
Sbjct: 145 AGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAG 204

Query: 190 VRGRQAGVCFGDSGSPLVCNG-----LIHGIASF-VRGGCASGLYPDAFAPVAQFVNWID 243
             G     C GDSG PL C        +HGI SF  R GC     P  F  V+ +++WI+
Sbjct: 205 GDG-VISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWIN 263

Query: 244 SII 246
           S+I
Sbjct: 264 SVI 266


>gi|62526043 chymotrypsin C preproprotein [Homo sapiens]
          Length = 268

 Score =  120 bits (301), Expect = 1e-27
 Identities = 88/244 (36%), Positives = 125/244 (51%), Gaps = 24/244 (9%)

Query: 26  LASEIVGGRRARPHAWPFMVSLQLRGG----HFCGATLIAPNFVMSAAHCVANVNVRAVR 81
           L++ +VGG  ARPH+WP+ +SLQ        H CG TLIA NFV++AAHC++  N R  R
Sbjct: 26  LSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCIS--NTRTYR 83

Query: 82  VVLGAHNLSRREPTRQVF-AVQRI-FENGYDPVNLLNDIVILQLNGSATINANVQVAQLP 139
           V +G +NL   +    +F  V  I     ++ + L NDI +++L     ++  +QVA LP
Sbjct: 84  VAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLP 143

Query: 140 AQGRRLGNGVQCLAMGWGLLGRNRGIASVLQE-LNVTVVTSLCRRSN------VCTLVRG 192
            +   L     C   GWG L  N  IA  LQ+ L   V  + C R +        T+V  
Sbjct: 144 EKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCA 203

Query: 193 RQAGV---CFGDSGSPLVC---NGL--IHGIASF-VRGGCASGLYPDAFAPVAQFVNWID 243
              GV   C GDSG PL C   NG   + GI SF  R GC +   P  +  V+ +++WI+
Sbjct: 204 GGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWIN 263

Query: 244 SIIQ 247
             +Q
Sbjct: 264 EKMQ 267


>gi|15529990 granzyme H [Homo sapiens]
          Length = 246

 Score =  120 bits (301), Expect = 1e-27
 Identities = 81/248 (32%), Positives = 124/248 (50%), Gaps = 22/248 (8%)

Query: 15  VLPALLLGGTALASEIVGGRRARPHAWPFMVSLQL---RGGHFCGATLIAPNFVMSAAHC 71
           +L A LL   A   EI+GG  A+PH+ P+M  +Q    +    CG  L+  +FV++AAHC
Sbjct: 6   LLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAHC 65

Query: 72  VANVNVRAVRVVLGAHNLSRREPTRQVFAVQR-IFENGYDPVNLLNDIVILQLNGSATIN 130
             +    ++ V LGAHN+  +E T+Q   V+R I    Y+P N  NDI++LQL   A   
Sbjct: 66  QGS----SINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWT 121

Query: 131 ANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVT----------SL 180
             V+  +LP+   ++  G  C   GWG +  +  +A+ LQE+ +TV            + 
Sbjct: 122 TAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMST-LATTLQEVLLTVQKDCQCERLFHGNY 180

Query: 181 CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN 240
            R + +C     +      GDSG PLVC  +  GI S+   G   G  P  +  V+ F+ 
Sbjct: 181 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSY---GNKKGTPPGVYIKVSHFLP 237

Query: 241 WIDSIIQR 248
           WI   ++R
Sbjct: 238 WIKRTMKR 245


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  120 bits (300), Expect = 2e-27
 Identities = 83/237 (35%), Positives = 122/237 (51%), Gaps = 24/237 (10%)

Query: 30  IVGGRRARPHAWPFMVSLQLRGG-HFCGATLIAPNFVMSAAHCV-ANVNVRAVRVVLGAH 87
           +VGG  A PH+WP+ VSL+ R G HFCG TLI+P +V++AAHC+  +    + +V+LGAH
Sbjct: 581 VVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAH 640

Query: 88  NLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGN 147
                EP  Q   V R+F    +P     DI +L+L+  A I   V  A LP+    + +
Sbjct: 641 QEVNLEPHVQEIEVSRLF---LEPTR--KDIALLKLSSPAVITDKVIPACLPSPNYVVAD 695

Query: 148 GVQCLAMGWGLLGRNRGIASVLQELNVTVV-TSLCRRSNVCT-------LVRGRQAG--- 196
             +C   GWG      G A +L+E  + V+   +C R            L  G  AG   
Sbjct: 696 RTECFITGWGETQGTFG-AGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTD 754

Query: 197 VCFGDSGSPLVC----NGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRS 249
            C GDSG PLVC      ++ G+ S+   GCA    P  +  V++FV WI+ +++ +
Sbjct: 755 SCQGDSGGPLVCFEKDKYILQGVTSWGL-GCARPNKPGVYVRVSRFVTWIEGVMRNN 810


>gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]
          Length = 2040

 Score =  118 bits (295), Expect = 6e-27
 Identities = 77/227 (33%), Positives = 115/227 (50%), Gaps = 13/227 (5%)

Query: 30   IVGGRRARPHAWPFMVSLQLR-GGHFCGATLIAPNFVMSAAHCV-ANVNVRAVRVVLGAH 87
            IVGG  A PH+WP+ VSL+ R G HFCG TLI+P +V++AAHC+  +    + +V+LGAH
Sbjct: 1820 IVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAH 1879

Query: 88   NLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGN 147
                 E   Q   V R+F    +P     DI +L+L+  A I   V  A LP+    +  
Sbjct: 1880 QEVNLESHVQEIEVSRLF---LEPTQA--DIALLKLSRPAVITDKVMPACLPSPDYMVTA 1934

Query: 148  GVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRR-SNVCTLVRGRQAGVCFGDSGSPL 206
              +C   GWG      G   + +   + +   +C     +C     R    C GDSG PL
Sbjct: 1935 RTECYITGWGETQGTFGTGLLKEAQLLVIENEVCNHYKYICAEHLARGTDSCQGDSGGPL 1994

Query: 207  VC----NGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRS 249
            VC      ++ G+ S+   GCA    P  +A V++FV WI+ +++ +
Sbjct: 1995 VCFEKDKYILQGVTSWGL-GCARPNKPGVYARVSRFVTWIEGMMRNN 2040


>gi|6679625 elastase 3B, pancreatic preproprotein [Homo sapiens]
          Length = 270

 Score =  117 bits (294), Expect = 8e-27
 Identities = 88/268 (32%), Positives = 129/268 (48%), Gaps = 30/268 (11%)

Query: 5   RRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGG----HFCGATLI 60
           R L+ L L  V        +  +S +V G  A P++WP+ VSLQ        H CG +LI
Sbjct: 4   RLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLI 63

Query: 61  APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQR--IFEN---GYDPVNLL 115
           AP++V++A HC+++   R  +VVLG ++ + +E   QV  +    +F +       V   
Sbjct: 64  APDWVVTAGHCISSS--RTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVACG 121

Query: 116 NDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVT 175
           NDI +++L+ SA +   VQ+A LP  G  L N   C   GWG L  N  +   LQE  + 
Sbjct: 122 NDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALLP 181

Query: 176 VVT-----------SLCRRSNVCTLVRGRQAGVCFGDSGSPLVC-----NGLIHGIASFV 219
           VV            S  +++ VC    G     C GDSG PL C        +HG+ SFV
Sbjct: 182 VVDYEHCSRWNWWGSSVKKTMVC--AGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFV 239

Query: 220 RG-GCASGLYPDAFAPVAQFVNWIDSII 246
              GC +   P  F  V+ F++WI+  I
Sbjct: 240 SAFGCNTRRKPTVFTRVSAFIDWIEETI 267


>gi|236460050 elastase 3A, pancreatic preproprotein [Homo sapiens]
          Length = 270

 Score =  117 bits (293), Expect = 1e-26
 Identities = 88/268 (32%), Positives = 128/268 (47%), Gaps = 30/268 (11%)

Query: 5   RRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGG----HFCGATLI 60
           R L+ L L  V        +  +S +V G  A P++WP+ VSLQ        H CG +LI
Sbjct: 4   RLLSSLLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLI 63

Query: 61  APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAV--QRIFEN---GYDPVNLL 115
           AP++V++A HC++       +VVLG +NL+ +E   QV  +  + +F +       V   
Sbjct: 64  APDWVVTAGHCISRD--LTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACG 121

Query: 116 NDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVT 175
           NDI +++L+ SA +   VQ+A LP  G  L N   C   GWG L  N  +   LQ+  + 
Sbjct: 122 NDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLP 181

Query: 176 VVT-----------SLCRRSNVCTLVRGRQAGVCFGDSGSPLVC-----NGLIHGIASFV 219
           VV            S  +++ VC    G     C GDSG PL C        +HG+ SFV
Sbjct: 182 VVDYKHCSRWNWWGSTVKKTMVC--AGGYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFV 239

Query: 220 RG-GCASGLYPDAFAPVAQFVNWIDSII 246
              GC     P  F  V+ F++WI+  I
Sbjct: 240 SAFGCNFIWKPTVFTRVSAFIDWIEETI 267


>gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo
           sapiens]
          Length = 254

 Score =  117 bits (292), Expect = 1e-26
 Identities = 75/233 (32%), Positives = 116/233 (49%), Gaps = 18/233 (7%)

Query: 28  SEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAH 87
           S+I+ G    PH+ P+  +L +    FC   L+ P +V+SAAHC  N    +  + LG H
Sbjct: 29  SQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQN----SYTIGLGLH 84

Query: 88  NLSR-REPTRQ-VFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRL 145
           +L   +EP  Q V A   +    Y+   L ND+++++L+ S + +  ++   + +Q    
Sbjct: 85  SLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTA 144

Query: 146 GNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTS---------LCRRSNVCTLVRGRQAG 196
           GN   CL  GWGLL   R + +VLQ +NV+VV+          L   S  C      Q  
Sbjct: 145 GNS--CLVSGWGLLANGR-MPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGHDQKD 201

Query: 197 VCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRS 249
            C GDSG PL+CNG + G+ SF +  C     P  +  + +F  WI+  +Q S
Sbjct: 202 SCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS 254


>gi|58331211 elastase 2B preproprotein [Homo sapiens]
          Length = 269

 Score =  115 bits (287), Expect = 5e-26
 Identities = 80/243 (32%), Positives = 118/243 (48%), Gaps = 27/243 (11%)

Query: 28  SEIVGGRRARPHAWPFMVSLQLRGG----HFCGATLIAPNFVMSAAHCVANVNVRAVRVV 83
           S ++GG  ARP++WP+ VSLQ        H CG +LIA ++V++AAHC+++  +   RV+
Sbjct: 27  SRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCGGSLIANSWVLTAAHCISSSGI--YRVM 84

Query: 84  LGAHNLSRREPTRQVFAVQRIFEN---GYDPVNLLNDIVILQLNGSATINANVQVAQLPA 140
           LG HNL   E      +V +I  +     D V+  NDI +L+L    ++   +Q+A LP 
Sbjct: 85  LGQHNLYVAESGSLAVSVSKIVVHKDWNSDQVSKGNDIALLKLANPVSLTDKIQLACLPP 144

Query: 141 QGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVT-----------SLCRRSNVCTL 189
            G  L N   C   GWG L  N  +   L++  + VV            S  + + +C  
Sbjct: 145 AGTILPNNYPCYVTGWGRLQTNGALPDDLKQGRLLVVDYATCSSSGWWGSTVKTNMICAG 204

Query: 190 VRGRQAGVCFGDSGSPLVCNGL-----IHGIASFVRG-GCASGLYPDAFAPVAQFVNWID 243
             G     C GDSG PL C        +HGI S     GC     P  F  V+ + +WI+
Sbjct: 205 GDG-VICTCNGDSGGPLNCQASDGRWEVHGIGSLTSVLGCNYYYKPSIFTRVSNYNDWIN 263

Query: 244 SII 246
           S+I
Sbjct: 264 SVI 266


>gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]
          Length = 247

 Score =  114 bits (284), Expect = 1e-25
 Identities = 78/251 (31%), Positives = 119/251 (47%), Gaps = 20/251 (7%)

Query: 10  LFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGH----FCGATLIAPNFV 65
           L L   L   LL   A A EI+GG   +PH+ P+M  L++   +    FCG  LI  NFV
Sbjct: 2   LLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFV 61

Query: 66  MSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENG-YDPVNLLNDIVILQLN 124
           ++AAHC      R++ V LGAHN++  E T Q   V + F +  Y+   L +DI++L+L 
Sbjct: 62  LTAAHCAG----RSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLK 117

Query: 125 GSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVV------- 177
             A++   V     P+Q   +  G  C   GWG  G  +  +  LQE+ + ++       
Sbjct: 118 EKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSH 177

Query: 178 -TSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVA 236
                    +C     +      GDSG PL+C G+  GI S+   G +    P  F  ++
Sbjct: 178 FRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSY---GRSDAKPPAVFTRIS 234

Query: 237 QFVNWIDSIIQ 247
            +  WI+ I+Q
Sbjct: 235 HYRPWINQILQ 245


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  114 bits (284), Expect = 1e-25
 Identities = 76/242 (31%), Positives = 119/242 (49%), Gaps = 22/242 (9%)

Query: 26  LASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCV-ANVNVRAVRVVL 84
           L+  I GG  A PH WP+ V L+  G + CG  +I P ++++AAHCV    N  +  ++ 
Sbjct: 571 LSRRIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHCVQLKNNPLSWTIIA 630

Query: 85  GAHNLSRREPTRQVFAVQRIF-ENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGR 143
           G H+ + +E T QV   + I     ++ ++  +DI ++QL+     N+ V+   LP    
Sbjct: 631 GDHDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAE 690

Query: 144 RLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVV-TSLCRRS------------NVCT-L 189
            L +   C   GWG +  + G+AS LQ++ V V+   +C  +             +C   
Sbjct: 691 PLFSSEICAVTGWGSISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGF 750

Query: 190 VRGRQAGVCFGDSGSPLVC---NG--LIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDS 244
               +   C GDSG PLVC   NG  +++GI S+   GC     P  FA V  F++WI S
Sbjct: 751 AASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSW-GAGCVQPWKPGVFARVMIFLDWIQS 809

Query: 245 II 246
            I
Sbjct: 810 KI 811



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 67/230 (29%), Positives = 110/230 (47%), Gaps = 24/230 (10%)

Query: 23  GTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVN---VRA 79
           G+   S I   R +     P+ VSL+    HFCG +LI  + V++AAHC+ +++   ++ 
Sbjct: 40  GSRFFSRISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKN 99

Query: 80  VRVVLGAHNLSRREPTRQVFAVQRIFEN-GYDPVNLLN-DIVILQLNGSATINANVQVAQ 137
           + V  G ++L +++   Q   V +I  +  Y+    ++ DI +L L         VQ   
Sbjct: 100 ITVTSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPIC 159

Query: 138 LPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNV---------TVVTSL----CRRS 184
           LP    ++  G+ CL+ GWG + +    ++VLQE+ +         TV+ S+      R+
Sbjct: 160 LPDSDDKVEPGILCLSSGWGKISKTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRT 219

Query: 185 NVCTLVRGRQAGVCFGDSGSPLVCN-----GLIHGIASFVRGGCASGLYP 229
            +C          C GDSG PLVC       ++ GI S+V  GCA G  P
Sbjct: 220 MLCAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSWV-AGCAGGSVP 268


>gi|4502173 prostate specific antigen isoform 1 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  113 bits (283), Expect = 2e-25
 Identities = 79/243 (32%), Positives = 119/243 (48%), Gaps = 28/243 (11%)

Query: 26  LASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLG 85
           + S IVGG     H+ P+ V +  RG   CG  L+ P +V++AAHC+ N +V    ++LG
Sbjct: 21  ILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSV----ILLG 76

Query: 86  AHNLSRREPTRQVFAVQRIFENGYDPVNLL------------NDIVILQLNGSATINANV 133
            H+L   E T QVF V   F +    ++LL            +D+++L+L+  A +   V
Sbjct: 77  RHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAV 136

Query: 134 QVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIA-SVLQELNVTVVTS-LC-----RRSNV 186
           +V  LP Q   L  G  C A GWG +     +    LQ +++ V+++ +C     ++   
Sbjct: 137 KVMDLPTQEPAL--GTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTK 194

Query: 187 CTLVRGRQAG---VCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWID 243
             L  GR  G    C GDSG PLVCNG++ GI S+    CA    P  +  V  +  WI 
Sbjct: 195 FMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIK 254

Query: 244 SII 246
             I
Sbjct: 255 DTI 257


>gi|4504235 granzyme K precursor [Homo sapiens]
          Length = 264

 Score =  113 bits (282), Expect = 2e-25
 Identities = 77/237 (32%), Positives = 121/237 (51%), Gaps = 27/237 (11%)

Query: 29  EIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVAN-VNVRAVRVVLGAH 87
           EI+GG+   PH+ PFM S+Q  G H CG  LI P +V++AAHC       ++  VVLGAH
Sbjct: 26  EIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVVLGAH 85

Query: 88  NLSRREPTRQVFAVQRIFENG---YDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRR 144
           +LS+ E ++Q   +++         DP +  NDI++++L  +A +N +V++  + ++   
Sbjct: 86  SLSKNEASKQTLEIKKFIPFSRVTSDPQS--NDIMLVKLQTAAKLNKHVKMLHIRSK-TS 142

Query: 145 LGNGVQCLAMGWGLLGRNR-GIASVLQELNVTVVT-SLCR------------RSNVCTLV 190
           L +G +C   GWG    +    +  L+E+ VTV++  LC             +  VC   
Sbjct: 143 LRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAGD 202

Query: 191 RGRQAGVCFGDSGSPLVCNGLIHGIASFVRGG--CASGLYPDAFAPVA-QFVNWIDS 244
              Q   C GDSG PL+C G+ H I S   GG  C     P  +  +  ++  WI S
Sbjct: 203 AKGQKDSCKGDSGGPLICKGVFHAIVS---GGHECGVATKPGIYTLLTKKYQTWIKS 256


>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
          Length = 247

 Score =  105 bits (263), Expect = 3e-23
 Identities = 78/231 (33%), Positives = 109/231 (47%), Gaps = 23/231 (9%)

Query: 29  EIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHN 88
           +IVGG     ++ P+ VSL   G HFCG +LI   +V+SA HC  +     ++V LG HN
Sbjct: 23  KIVGGYNCEENSVPYQVSLN-SGYHFCGGSLINEQWVVSAGHCYKS----RIQVRLGEHN 77

Query: 89  LSRREPTRQVFAVQRIFENG-YDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGN 147
           +   E   Q     +I  +  YD   L NDI++++L+  A INA V    LP        
Sbjct: 78  IEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPP--AT 135

Query: 148 GVQCLAMGWG-LLGRNRGIASVLQELNVTVVTSL-CRRSN----------VCTLVRGRQA 195
           G +CL  GWG            LQ L+  V++   C  S           V  L  G+ +
Sbjct: 136 GTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDS 195

Query: 196 GVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSII 246
             C GDSG P+VCNG + G+ S+   GCA    P  +  V  +V WI + I
Sbjct: 196 --CQGDSGGPVVCNGQLQGVVSW-GDGCAQKNKPGVYTKVYNYVKWIKNTI 243


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  105 bits (263), Expect = 3e-23
 Identities = 81/248 (32%), Positives = 119/248 (47%), Gaps = 22/248 (8%)

Query: 22  GGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAV- 80
           G   LAS IVGG+   P  WP+  S+ L   H CG +++AP +V++AAHC+ +  +  + 
Sbjct: 210 GARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLS 269

Query: 81  --RVVLGAHNLSRREPTRQVFAVQRIFENG-YDPVNLLNDIVILQLNGSATINANVQVAQ 137
             RV  G  + S   P  Q   V+RI  +  Y   N   D+ +L+L  +   +  V    
Sbjct: 270 SWRVHAGLVSHSAVRP-HQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVC 328

Query: 138 LPAQGRRLGNGVQCLAMGWGLLGRNRGIAS-VLQELNVTVV-TSLCRRSNV--------- 186
           LPA+ +    G +C   GWG    +   +S +LQ+  V +  T LC  S V         
Sbjct: 329 LPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRM 388

Query: 187 -CTLVRGRQAGVCFGDSGSPLVC----NGLIHGIASFVRGGCASGLYPDAFAPVAQFVNW 241
            C      +A  C GDSG PLVC       + G+ S+ R GCA   +P  +A VA+F++W
Sbjct: 389 LCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGR-GCAEPNHPGVYAKVAEFLDW 447

Query: 242 IDSIIQRS 249
           I    Q S
Sbjct: 448 IHDTAQDS 455


>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
          Length = 304

 Score =  104 bits (259), Expect = 9e-23
 Identities = 78/229 (34%), Positives = 110/229 (48%), Gaps = 19/229 (8%)

Query: 29  EIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHN 88
           +IVGG     ++ P+ VSL   G HFCG +LI+  +V+SAAHC        ++V LG HN
Sbjct: 80  KIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHCYKT----RIQVRLGEHN 134

Query: 89  LSRREPTRQVFAVQRIFEN-GYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGN 147
           +   E   Q     +I  +  Y+   L NDI++++L+  A INA V    LP        
Sbjct: 135 IKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPP--AA 192

Query: 148 GVQCLAMGWG-LLGRNRGIASVLQELNVTVVTSL-CRRS------NVCTLVRGRQAG--V 197
           G +CL  GWG  L         L+ L+  V+T   C+ S      N    V   + G   
Sbjct: 193 GTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDS 252

Query: 198 CFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSII 246
           C  DSG P+VCNG + G+ S+   GCA    P  +  V  +V+WI   I
Sbjct: 253 CQRDSGGPVVCNGQLQGVVSWGH-GCAWKNRPGVYTKVYNYVDWIKDTI 300


>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  104 bits (259), Expect = 9e-23
 Identities = 78/229 (34%), Positives = 110/229 (48%), Gaps = 19/229 (8%)

Query: 29  EIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHN 88
           +IVGG     ++ P+ VSL   G HFCG +LI+  +V+SAAHC        ++V LG HN
Sbjct: 23  KIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHCYKT----RIQVRLGEHN 77

Query: 89  LSRREPTRQVFAVQRIFEN-GYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGN 147
           +   E   Q     +I  +  Y+   L NDI++++L+  A INA V    LP        
Sbjct: 78  IKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPP--AA 135

Query: 148 GVQCLAMGWG-LLGRNRGIASVLQELNVTVVTSL-CRRS------NVCTLVRGRQAG--V 197
           G +CL  GWG  L         L+ L+  V+T   C+ S      N    V   + G   
Sbjct: 136 GTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDS 195

Query: 198 CFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSII 246
           C  DSG P+VCNG + G+ S+   GCA    P  +  V  +V+WI   I
Sbjct: 196 CQRDSGGPVVCNGQLQGVVSWGH-GCAWKNRPGVYTKVYNYVDWIKDTI 243


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  103 bits (258), Expect = 1e-22
 Identities = 89/272 (32%), Positives = 119/272 (43%), Gaps = 41/272 (15%)

Query: 27  ASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHC-VANVNVRAV---RV 82
           ++ IVGG  A+P  WP+ VSL   GGH CG +LIAP++V+SAAHC + N  +       V
Sbjct: 44  SARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSV 103

Query: 83  VLGAHNLSRREP-----TRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQ 137
           +LG H  S+  P     TR V A+  +    Y  V L  D+ +L+L   A++   V    
Sbjct: 104 LLGVH--SQDGPLDGAHTRAVAAI--VVPANYSQVELGADLALLRLASPASLGPAVWPVC 159

Query: 138 LPAQGRRLGNGVQCLAMGWGLLGRNRGIAS--VLQELNVTVV---TSLCRRSN------- 185
           LP    R  +G  C A GWG +     +    VLQE+ + ++   T  C  S        
Sbjct: 160 LPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLT 219

Query: 186 -------VCTLVRGRQAGVCFGDSGSPLVC----NGLIHGIASFVRGGCASGLYPDAFAP 234
                  +C      +   C GDSG PLVC         GI SF   GC     P  F  
Sbjct: 220 LQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSF-GFGCGRRNRPGVFTA 278

Query: 235 VAQFVNWIDSIIQRSEDNPC----PHPRDPDP 262
           VA +  WI   +  SE  P     P     DP
Sbjct: 279 VATYEAWIREQVMGSEPGPAFPTQPQKTQSDP 310



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 47/217 (21%), Positives = 84/217 (38%), Gaps = 21/217 (9%)

Query: 41  WPFMVSLQLRGGHFCGATLIAPNFVMSAAHCV---ANVNVRAVRVVLGAHNLSR----RE 93
           WP++  + + G   C   L+AP +V++A HCV    +  V  + V LG    S      +
Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660

Query: 94  PTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLA 153
            +R V +++     G  P      + +L+L  S+ +  +     +      +  G  C  
Sbjct: 661 VSRLVISIRLPQHLGLRP-----PLALLEL--SSRVEPSPSALPICLHPAGIPPGASCWV 713

Query: 154 MGWGLLGRNRGIASVLQELNVTVVTSLCR----RSNVCTLVRGRQAGVCFGDSGSPLVCN 209
           +GW        +A+ +  L   +   L +       +C L    Q   C   S  PL+C 
Sbjct: 714 LGWKEPQDRVPVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQ 773

Query: 210 GLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSII 246
            +  G  S++  G A     + FA +     WI   +
Sbjct: 774 -MTEG--SWILVGMAVQGSRELFAAIGPEEAWISQTV 807



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 55/240 (22%), Positives = 91/240 (37%), Gaps = 39/240 (16%)

Query: 33  GRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVN--------VRAVRVVL 84
           G+  RP AWP+   + + G   C   L++ ++V++ A C  + N        + A RV+L
Sbjct: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385

Query: 85  GAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRR 144
            +   + R        V R+ ++     +  +D+ +LQL     ++A  +   LP     
Sbjct: 386 PSRPRAER--------VARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHY 437

Query: 145 LGNGVQCLAMGWGLLGRNRGIASVLQE--LNVTVVTSLCRRSNVCTLVRG---------- 192
              G +C    WG      G  ++L+   L       L  R      + G          
Sbjct: 438 FLPGSRCRLARWGRGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAY 497

Query: 193 ---RQAGVCFGDSGSPLVC----NGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSI 245
               + G C+ DS   L+C       + GI  F   GC   L P AF P+     WI  +
Sbjct: 498 QEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDF-PSGC---LRPRAFFPLQTHGPWISHV 553


>gi|4503137 chymotrypsin-like [Homo sapiens]
          Length = 264

 Score =  103 bits (258), Expect = 1e-22
 Identities = 81/252 (32%), Positives = 125/252 (49%), Gaps = 28/252 (11%)

Query: 14  CVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGG-HFCGATLIAPNFVMSAAHCV 72
           C +PA+     + +  IV G  A   +WP+ VSLQ   G HFCG +LI+ ++V++AAHC 
Sbjct: 19  CGIPAIK-PALSFSQRIVNGENAVLGSWPWQVSLQDSSGFHFCGGSLISQSWVVTAAHC- 76

Query: 73  ANVNVRAVRVVLGAHNLSRREPTRQVFAVQR-IFENGYDPVNLLNDIVILQLNGSATINA 131
            NV+     VVLG ++ S      QV +V R I    ++   + ND+ +L+L   A    
Sbjct: 77  -NVSPGRHFVVLGEYDRSSNAEPLQVLSVSRAITHPSWNSTTMNNDVTLLKLASPAQYTT 135

Query: 132 NVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASV----LQELNVTVVT-SLCRR--- 183
            +    L +    L  G+ C+  GWG L    G+ +V    LQ++ + +VT + CR+   
Sbjct: 136 RISPVCLASSNEALTEGLTCVTTGWGRLS---GVGNVTPAHLQQVALPLVTVNQCRQYWG 192

Query: 184 -----SNVCTLVRGRQAGVCFGDSGSPLVC----NGLIHGIASFVRGGCASGLYPDAFAP 234
                S +C    G  A  C GDSG PLVC      ++ GI S+    C +   P  +  
Sbjct: 193 SSITDSMIC--AGGAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNC-NVRAPAVYTR 249

Query: 235 VAQFVNWIDSII 246
           V++F  WI+ +I
Sbjct: 250 VSKFSTWINQVI 261


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.140    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,354,324
Number of Sequences: 37866
Number of extensions: 443513
Number of successful extensions: 1687
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1202
Number of HSP's gapped (non-prelim): 185
length of query: 267
length of database: 18,247,518
effective HSP length: 100
effective length of query: 167
effective length of database: 14,460,918
effective search space: 2414973306
effective search space used: 2414973306
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.