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Search of human proteins with 126116589
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126116589 fibrocystin L [Homo sapiens]
(4243 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126116589 fibrocystin L [Homo sapiens] 8658 0.0
gi|126131102 fibrocystin isoform 1 [Homo sapiens] 758 0.0
gi|126131104 fibrocystin isoform 2 [Homo sapiens] 694 0.0
gi|7019555 transmembrane protein 2 isoform a [Homo sapiens] 166 3e-40
gi|209447096 transmembrane protein 2 isoform b [Homo sapiens] 143 3e-33
gi|38638698 KIAA1199 [Homo sapiens] 141 2e-32
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens] 71 2e-11
gi|113722116 plexin A2 [Homo sapiens] 70 6e-11
gi|59710104 plexin A3 [Homo sapiens] 69 8e-11
gi|157738645 plexin A4 isoform 1 [Homo sapiens] 68 2e-10
gi|49355818 plexin A1 [Homo sapiens] 68 2e-10
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens] 67 3e-10
gi|157694524 plexin D1 [Homo sapiens] 66 8e-10
gi|194272180 plexin B1 [Homo sapiens] 63 5e-09
gi|40254442 plexin B1 [Homo sapiens] 63 5e-09
gi|149363636 plexin B2 [Homo sapiens] 54 3e-06
gi|253795481 plexin B3 isoform 2 [Homo sapiens] 51 2e-05
gi|29336063 plexin B3 isoform 1 [Homo sapiens] 51 2e-05
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s... 46 7e-04
gi|32967607 glutathione peroxidase 2 [Homo sapiens] 37 0.55
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 35 2.1
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 35 2.1
gi|209862845 nuclear factor of activated T-cells, cytoplasmic, c... 34 2.7
gi|27886563 nuclear factor of activated T-cells, cytoplasmic, ca... 34 2.7
gi|57546899 myeloid/lymphoid or mixed-lineage leukemia transloca... 34 2.7
gi|4757726 myeloid/lymphoid or mixed-lineage leukemia translocat... 34 2.7
gi|31415878 early B-cell factor [Homo sapiens] 34 2.7
gi|53828926 early B-cell factor 3 [Homo sapiens] 33 4.6
gi|113930703 early B-cell factor 2 [Homo sapiens] 33 4.6
gi|149588928 SLAIN motif family, member 2 [Homo sapiens] 33 4.6
>gi|126116589 fibrocystin L [Homo sapiens]
Length = 4243
Score = 8658 bits (22466), Expect = 0.0
Identities = 4243/4243 (100%), Positives = 4243/4243 (100%)
Query: 1 MGHLWLLGIWGLCGLLLCAADPSTDGSQIIPKVTEIIPKYGSINGATRLTIRGEGFSQAN 60
MGHLWLLGIWGLCGLLLCAADPSTDGSQIIPKVTEIIPKYGSINGATRLTIRGEGFSQAN
Sbjct: 1 MGHLWLLGIWGLCGLLLCAADPSTDGSQIIPKVTEIIPKYGSINGATRLTIRGEGFSQAN 60
Query: 61 QFNYGVDNAELGNSVQLISSFQSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGVP 120
QFNYGVDNAELGNSVQLISSFQSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGVP
Sbjct: 61 QFNYGVDNAELGNSVQLISSFQSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGVP 120
Query: 121 VTENNTCKGHINSWECTFNAKSFRTPTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALS 180
VTENNTCKGHINSWECTFNAKSFRTPTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALS
Sbjct: 121 VTENNTCKGHINSWECTFNAKSFRTPTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALS 180
Query: 181 SNGKNVRILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIGHHNVSFI 240
SNGKNVRILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIGHHNVSFI
Sbjct: 181 SNGKNVRILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIGHHNVSFI 240
Query: 241 LDNDYGRSFPQKMAYFVSSLNKIAMFQTYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDF 300
LDNDYGRSFPQKMAYFVSSLNKIAMFQTYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDF
Sbjct: 241 LDNDYGRSFPQKMAYFVSSLNKIAMFQTYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDF 300
Query: 301 PVRVLVGGEPCDILNVTENSICCKTPPKPHILKTVYPGGRGLKLEVWNNSRPIRLEEILE 360
PVRVLVGGEPCDILNVTENSICCKTPPKPHILKTVYPGGRGLKLEVWNNSRPIRLEEILE
Sbjct: 301 PVRVLVGGEPCDILNVTENSICCKTPPKPHILKTVYPGGRGLKLEVWNNSRPIRLEEILE 360
Query: 361 YNEKTPGYMGASWVDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSQ 420
YNEKTPGYMGASWVDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSQ
Sbjct: 361 YNEKTPGYMGASWVDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSQ 420
Query: 421 TGLPEDKVRIAYHSANANSYFSSPTQRSDDIHLQKGKEYYIEILLQEYRLSAFVDVGLYQ 480
TGLPEDKVRIAYHSANANSYFSSPTQRSDDIHLQKGKEYYIEILLQEYRLSAFVDVGLYQ
Sbjct: 421 TGLPEDKVRIAYHSANANSYFSSPTQRSDDIHLQKGKEYYIEILLQEYRLSAFVDVGLYQ 480
Query: 481 YRNVYTEQQTGDAVNEEQVIKSQSTILQEVQVITLENWETTNAINEVQKIKVTSPCVEAN 540
YRNVYTEQQTGDAVNEEQVIKSQSTILQEVQVITLENWETTNAINEVQKIKVTSPCVEAN
Sbjct: 481 YRNVYTEQQTGDAVNEEQVIKSQSTILQEVQVITLENWETTNAINEVQKIKVTSPCVEAN 540
Query: 541 SCSLYQYRLIYNMEKTVFLPADASEFILQSALNDLWSIKPDTVQVIRTQNPQSYVYMVTF 600
SCSLYQYRLIYNMEKTVFLPADASEFILQSALNDLWSIKPDTVQVIRTQNPQSYVYMVTF
Sbjct: 541 SCSLYQYRLIYNMEKTVFLPADASEFILQSALNDLWSIKPDTVQVIRTQNPQSYVYMVTF 600
Query: 601 ISTRGDFDLLGYEVVEGNNVTLDITEQTKGKPNLETFTLNWDGIASKPLTLWSSEAEFQG 660
ISTRGDFDLLGYEVVEGNNVTLDITEQTKGKPNLETFTLNWDGIASKPLTLWSSEAEFQG
Sbjct: 601 ISTRGDFDLLGYEVVEGNNVTLDITEQTKGKPNLETFTLNWDGIASKPLTLWSSEAEFQG 660
Query: 661 AVEEMVSTKCPPQIANFEEGFVVKYFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPA 720
AVEEMVSTKCPPQIANFEEGFVVKYFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPA
Sbjct: 661 AVEEMVSTKCPPQIANFEEGFVVKYFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPA 720
Query: 721 VLFDSADVKPNRRPYGDILLFPYNQLCLAYKGFLANYIGLKFQYQDNSKITRSTDTQFTY 780
VLFDSADVKPNRRPYGDILLFPYNQLCLAYKGFLANYIGLKFQYQDNSKITRSTDTQFTY
Sbjct: 721 VLFDSADVKPNRRPYGDILLFPYNQLCLAYKGFLANYIGLKFQYQDNSKITRSTDTQFTY 780
Query: 781 NFAYGNNWTYTCIDLLDLVRTKYTGTNVSLQRISLHKASESQSFYVDVVYIGHTSTISTL 840
NFAYGNNWTYTCIDLLDLVRTKYTGTNVSLQRISLHKASESQSFYVDVVYIGHTSTISTL
Sbjct: 781 NFAYGNNWTYTCIDLLDLVRTKYTGTNVSLQRISLHKASESQSFYVDVVYIGHTSTISTL 840
Query: 841 DEMPKRRLPALANKGIFLEHFQVNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQI 900
DEMPKRRLPALANKGIFLEHFQVNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQI
Sbjct: 841 DEMPKRRLPALANKGIFLEHFQVNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQI 900
Query: 901 ITHETENEFVYRGNNWPGESKIHIQRIQAASPPLSGSFDIQAYGHILKGLPAAVSAADLQ 960
ITHETENEFVYRGNNWPGESKIHIQRIQAASPPLSGSFDIQAYGHILKGLPAAVSAADLQ
Sbjct: 901 ITHETENEFVYRGNNWPGESKIHIQRIQAASPPLSGSFDIQAYGHILKGLPAAVSAADLQ 960
Query: 961 FALQSLEGMGRISVTREGTCAGYAWNIKWRSTCGKQNLLQINDSNIIGEKANMTVTRIKE 1020
FALQSLEGMGRISVTREGTCAGYAWNIKWRSTCGKQNLLQINDSNIIGEKANMTVTRIKE
Sbjct: 961 FALQSLEGMGRISVTREGTCAGYAWNIKWRSTCGKQNLLQINDSNIIGEKANMTVTRIKE 1020
Query: 1021 GGLFRQHVLGDLLRTPSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYE 1080
GGLFRQHVLGDLLRTPSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYE
Sbjct: 1021 GGLFRQHVLGDLLRTPSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYE 1080
Query: 1081 EGTILTIVGSGFSPSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGL 1140
EGTILTIVGSGFSPSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGL
Sbjct: 1081 EGTILTIVGSGFSPSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGL 1140
Query: 1141 AQNVGGEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNETCNVIEGDL 1200
AQNVGGEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNETCNVIEGDL
Sbjct: 1141 AQNVGGEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNETCNVIEGDL 1200
Query: 1201 NRITCRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTI 1260
NRITCRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTI
Sbjct: 1201 NRITCRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTI 1260
Query: 1261 KGYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFASTRD 1320
KGYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFASTRD
Sbjct: 1261 KGYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFASTRD 1320
Query: 1321 KLNSSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENV 1380
KLNSSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENV
Sbjct: 1321 KLNSSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENV 1380
Query: 1381 IKCILHSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLRGIGYRIF 1440
IKCILHSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLRGIGYRIF
Sbjct: 1381 IKCILHSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLRGIGYRIF 1440
Query: 1441 SVSSPGSVIYDGKGFTSGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVINVLP 1500
SVSSPGSVIYDGKGFTSGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVINVLP
Sbjct: 1441 SVSSPGSVIYDGKGFTSGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVINVLP 1500
Query: 1501 AETRHIPLHLFVGRSEATYAYGGPENLHLGSSVAGCLATEPLCSLNNTRVKNSKRLLFEV 1560
AETRHIPLHLFVGRSEATYAYGGPENLHLGSSVAGCLATEPLCSLNNTRVKNSKRLLFEV
Sbjct: 1501 AETRHIPLHLFVGRSEATYAYGGPENLHLGSSVAGCLATEPLCSLNNTRVKNSKRLLFEV 1560
Query: 1561 SSCFSPSISNITPSTGTVNELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHID 1620
SSCFSPSISNITPSTGTVNELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHID
Sbjct: 1561 SSCFSPSISNITPSTGTVNELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHID 1620
Query: 1621 PQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIK 1680
PQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIK
Sbjct: 1621 PQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIK 1680
Query: 1681 GSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVPAQCQGNCT 1740
GSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVPAQCQGNCT
Sbjct: 1681 GSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVPAQCQGNCT 1740
Query: 1741 FSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITA 1800
FSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITA
Sbjct: 1741 FSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITA 1800
Query: 1801 LVTPLPVGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYPGN 1860
LVTPLPVGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYPGN
Sbjct: 1801 LVTPLPVGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYPGN 1860
Query: 1861 TTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFTYALEDTPFLRG 1920
TTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFTYALEDTPFLRG
Sbjct: 1861 TTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFTYALEDTPFLRG 1920
Query: 1921 IIPSRGPPGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVM 1980
IIPSRGPPGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVM
Sbjct: 1921 IIPSRGPPGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVM 1980
Query: 1981 MHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAI 2040
MHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAI
Sbjct: 1981 MHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAI 2040
Query: 2041 DRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKR 2100
DRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKR
Sbjct: 2041 DRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKR 2100
Query: 2101 GSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVH 2160
GSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVH
Sbjct: 2101 GSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVH 2160
Query: 2161 IRGVGMAKLDNADFLYVDAWSSNFSWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLI 2220
IRGVGMAKLDNADFLYVDAWSSNFSWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLI
Sbjct: 2161 IRGVGMAKLDNADFLYVDAWSSNFSWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLI 2220
Query: 2221 QGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQHKAVITLHGHLRSPELPVYGAKT 2280
QGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQHKAVITLHGHLRSPELPVYGAKT
Sbjct: 2221 QGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQHKAVITLHGHLRSPELPVYGAKT 2280
Query: 2281 LAVREGILDLHGVPVPVTWTRLAHTAKAGERILILQEAVTWKPGDNIVIASTGHRHSQGE 2340
LAVREGILDLHGVPVPVTWTRLAHTAKAGERILILQEAVTWKPGDNIVIASTGHRHSQGE
Sbjct: 2281 LAVREGILDLHGVPVPVTWTRLAHTAKAGERILILQEAVTWKPGDNIVIASTGHRHSQGE 2340
Query: 2341 NEKMTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEVGILTRNILIRGSDNV 2400
NEKMTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEVGILTRNILIRGSDNV
Sbjct: 2341 NEKMTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEVGILTRNILIRGSDNV 2400
Query: 2401 EWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHAPVPGANMVTGRIEYV 2460
EWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHAPVPGANMVTGRIEYV
Sbjct: 2401 EWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHAPVPGANMVTGRIEYV 2460
Query: 2461 EVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYD 2520
EVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYD
Sbjct: 2461 EVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYD 2520
Query: 2521 IKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNAVAGGT 2580
IKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNAVAGGT
Sbjct: 2521 IKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNAVAGGT 2580
Query: 2581 HFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMWIFEEYFPMQTGSCTS 2640
HFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMWIFEEYFPMQTGSCTS
Sbjct: 2581 HFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMWIFEEYFPMQTGSCTS 2640
Query: 2641 TVPAPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIETKRILAPYVGGWGETN 2700
TVPAPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIETKRILAPYVGGWGETN
Sbjct: 2641 TVPAPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIETKRILAPYVGGWGETN 2700
Query: 2701 GAVIKNAKIVGHLDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMNFDRPNCVALGVTSIS 2760
GAVIKNAKIVGHLDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMNFDRPNCVALGVTSIS
Sbjct: 2701 GAVIKNAKIVGHLDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMNFDRPNCVALGVTSIS 2760
Query: 2761 GVCNDRCGGWSAKFVDVQYSHTPNKAGFRWEHEMVMIDVDGSLTGHKGHTVIPHSSLLDP 2820
GVCNDRCGGWSAKFVDVQYSHTPNKAGFRWEHEMVMIDVDGSLTGHKGHTVIPHSSLLDP
Sbjct: 2761 GVCNDRCGGWSAKFVDVQYSHTPNKAGFRWEHEMVMIDVDGSLTGHKGHTVIPHSSLLDP 2820
Query: 2821 SHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLSDSFGTSIIPFQKKRL 2880
SHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLSDSFGTSIIPFQKKRL
Sbjct: 2821 SHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLSDSFGTSIIPFQKKRL 2880
Query: 2881 THMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVIISHNFTQNPDMFNII 2940
THMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVIISHNFTQNPDMFNII
Sbjct: 2881 THMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVIISHNFTQNPDMFNII 2940
Query: 2941 DMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQLISGNLDPDVKDVVINF 3000
DMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQLISGNLDPDVKDVVINF
Sbjct: 2941 DMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQLISGNLDPDVKDVVINF 3000
Query: 3001 QAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSFWQSSRENNYTVPHPGANVIIPEG 3060
QAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSFWQSSRENNYTVPHPGANVIIPEG
Sbjct: 3001 QAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSFWQSSRENNYTVPHPGANVIIPEG 3060
Query: 3061 TWIVADIDMPSMERLIIWGVLELEDKYNVGAAESSYREVVLNATYISLQGGRLIGGWEDN 3120
TWIVADIDMPSMERLIIWGVLELEDKYNVGAAESSYREVVLNATYISLQGGRLIGGWEDN
Sbjct: 3061 TWIVADIDMPSMERLIIWGVLELEDKYNVGAAESSYREVVLNATYISLQGGRLIGGWEDN 3120
Query: 3121 PFKGDLKIVLRGNHTTQDWALPEGPNQGAKVLGVFGELDLHGIPHSIYKTKLSETAFAGS 3180
PFKGDLKIVLRGNHTTQDWALPEGPNQGAKVLGVFGELDLHGIPHSIYKTKLSETAFAGS
Sbjct: 3121 PFKGDLKIVLRGNHTTQDWALPEGPNQGAKVLGVFGELDLHGIPHSIYKTKLSETAFAGS 3180
Query: 3181 KVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKILILNDSLSYTHFAEKYH 3240
KVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKILILNDSLSYTHFAEKYH
Sbjct: 3181 KVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKILILNDSLSYTHFAEKYH 3240
Query: 3241 VPGTGESYTLAADVGILSRNIKIVGEDYPGWSEDSFGARVLVGSFTENMMTFKGNARISN 3300
VPGTGESYTLAADVGILSRNIKIVGEDYPGWSEDSFGARVLVGSFTENMMTFKGNARISN
Sbjct: 3241 VPGTGESYTLAADVGILSRNIKIVGEDYPGWSEDSFGARVLVGSFTENMMTFKGNARISN 3300
Query: 3301 VEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFHHGFSPAIGVFGTDGLDI 3360
VEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFHHGFSPAIGVFGTDGLDI
Sbjct: 3301 VEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFHHGFSPAIGVFGTDGLDI 3360
Query: 3361 DDNIIHFTVGEGIRIWGNANRVRGNLIALSVWPGTYQNRKDLSSTLWHAAIEINRGTNTV 3420
DDNIIHFTVGEGIRIWGNANRVRGNLIALSVWPGTYQNRKDLSSTLWHAAIEINRGTNTV
Sbjct: 3361 DDNIIHFTVGEGIRIWGNANRVRGNLIALSVWPGTYQNRKDLSSTLWHAAIEINRGTNTV 3420
Query: 3421 LQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLYGIYMNQDGLPGCSLIQGFT 3480
LQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLYGIYMNQDGLPGCSLIQGFT
Sbjct: 3421 LQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLYGIYMNQDGLPGCSLIQGFT 3480
Query: 3481 IWTCWDYGIYFQTTESVHIYNVTLVDNGMAIFPMIYMPAAISHKISSKNVQIKSSLIVGS 3540
IWTCWDYGIYFQTTESVHIYNVTLVDNGMAIFPMIYMPAAISHKISSKNVQIKSSLIVGS
Sbjct: 3481 IWTCWDYGIYFQTTESVHIYNVTLVDNGMAIFPMIYMPAAISHKISSKNVQIKSSLIVGS 3540
Query: 3541 SPGFNCSDVLTNDDPNIELTAAHRSPRSPSGGRSGICWPTFASAHNMAPRKPHAGIMSYN 3600
SPGFNCSDVLTNDDPNIELTAAHRSPRSPSGGRSGICWPTFASAHNMAPRKPHAGIMSYN
Sbjct: 3541 SPGFNCSDVLTNDDPNIELTAAHRSPRSPSGGRSGICWPTFASAHNMAPRKPHAGIMSYN 3600
Query: 3601 AISGLLDISGSTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSKIFIH 3660
AISGLLDISGSTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSKIFIH
Sbjct: 3601 AISGLLDISGSTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSKIFIH 3660
Query: 3661 RPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGSVIPQAEYEWDGNSQVGIGDYRI 3720
RPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGSVIPQAEYEWDGNSQVGIGDYRI
Sbjct: 3661 RPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGSVIPQAEYEWDGNSQVGIGDYRI 3720
Query: 3721 PKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEWQSYQCFGMEYAMMVIESLDPDTET 3780
PKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEWQSYQCFGMEYAMMVIESLDPDTET
Sbjct: 3721 PKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEWQSYQCFGMEYAMMVIESLDPDTET 3780
Query: 3781 RRLSPVAIMGNGYVDLINGPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTGTSPQNL 3840
RRLSPVAIMGNGYVDLINGPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTGTSPQNL
Sbjct: 3781 RRLSPVAIMGNGYVDLINGPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTGTSPQNL 3840
Query: 3841 RLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNLLVCPKTTIWNAQQKHCELNNHLYKDQFL 3900
RLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNLLVCPKTTIWNAQQKHCELNNHLYKDQFL
Sbjct: 3841 RLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNLLVCPKTTIWNAQQKHCELNNHLYKDQFL 3900
Query: 3901 PNLDSTVLGENYFDGTYQMLYLLVKGTIPVEIHTATVIFVSFQLSVATEDDFYTSHNLVK 3960
PNLDSTVLGENYFDGTYQMLYLLVKGTIPVEIHTATVIFVSFQLSVATEDDFYTSHNLVK
Sbjct: 3901 PNLDSTVLGENYFDGTYQMLYLLVKGTIPVEIHTATVIFVSFQLSVATEDDFYTSHNLVK 3960
Query: 3961 NLALFLKIPSDKIRISKIRGKSLRRKRSMGFIIEIEIGDPPIQFISNGTTGQMQLSELQE 4020
NLALFLKIPSDKIRISKIRGKSLRRKRSMGFIIEIEIGDPPIQFISNGTTGQMQLSELQE
Sbjct: 3961 NLALFLKIPSDKIRISKIRGKSLRRKRSMGFIIEIEIGDPPIQFISNGTTGQMQLSELQE 4020
Query: 4021 IAGSLGQAVILGNISSILGFNISSMSITNPLPSPSDSGWIKVTAQPVERSAFPVHHVAFV 4080
IAGSLGQAVILGNISSILGFNISSMSITNPLPSPSDSGWIKVTAQPVERSAFPVHHVAFV
Sbjct: 4021 IAGSLGQAVILGNISSILGFNISSMSITNPLPSPSDSGWIKVTAQPVERSAFPVHHVAFV 4080
Query: 4081 SSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITALTLRAILKDSNNNQVNGLSG 4140
SSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITALTLRAILKDSNNNQVNGLSG
Sbjct: 4081 SSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITALTLRAILKDSNNNQVNGLSG 4140
Query: 4141 NTTIPFSSCWANYTDLTPLRTGKNYKIEFILDNVVGVESRTFSLLAESVSSSGSSSSSNS 4200
NTTIPFSSCWANYTDLTPLRTGKNYKIEFILDNVVGVESRTFSLLAESVSSSGSSSSSNS
Sbjct: 4141 NTTIPFSSCWANYTDLTPLRTGKNYKIEFILDNVVGVESRTFSLLAESVSSSGSSSSSNS 4200
Query: 4201 KASTVGTYAQIMTVVISCLVGRMWLLEIFMAAVSTLNITLRSY 4243
KASTVGTYAQIMTVVISCLVGRMWLLEIFMAAVSTLNITLRSY
Sbjct: 4201 KASTVGTYAQIMTVVISCLVGRMWLLEIFMAAVSTLNITLRSY 4243
>gi|126131102 fibrocystin isoform 1 [Homo sapiens]
Length = 4074
Score = 758 bits (1957), Expect = 0.0
Identities = 717/2789 (25%), Positives = 1225/2789 (43%), Gaps = 352/2789 (12%)
Query: 1571 ITPSTGTVNELITIIGHGFSNLPWANKVTIGSYPCVVE-ESSEDSIT---CHIDPQNSMD 1626
+T G + + G SNL + + +G+ C VE +S + +++ C I P +S++
Sbjct: 1303 VTAMQGEITNSSLSLHVGGSNLS-NSVILLGNLNCDVETQSFQGNVSLSGCSI-PLHSLE 1360
Query: 1627 VGIRETVTLTVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIKGSGFAV 1686
GI L V +S ++F ++P I + P+ GS G T +T++G
Sbjct: 1361 AGI---YPLQVRQKQMGFANMSVVL-QQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNS 1416
Query: 1687 SSAGVKV-LMGHFPCKVLSVNYTAIECETS------PAAQQLVDVDLLIHGVPAQCQGNC 1739
V+V L G F C +LS+ I C+ S P A ++V +L++G+ ++CQGNC
Sbjct: 1417 RRRSVRVDLSGPFTCVILSLGDHTILCQVSLEGDPLPGASFSLNVTVLVNGLTSECQGNC 1476
Query: 1740 TFSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIGNQ-QFRAIEVNENNI 1798
T E +P + + N+ VLI G+ L T ++ VF+ +Q N +++
Sbjct: 1477 TLFIREEASPVMDALSTNTSGSLTTVLIRGQRLATTADEPMVFVDDQLPCNVTFFNASHV 1536
Query: 1799 TALVTPLPVGHHSVSVVVGSKGLAL-GNLT---VSSPPVASLSPTSGSIGGGTTLVITGN 1854
L G H +SV G A GN++ P V P + S+ GG+ L I G
Sbjct: 1537 VCQTRDLAPGPHYLSVFYTRNGYACSGNVSRHFYIMPQVFHYFPKNFSLHGGSLLTIEGT 1596
Query: 1855 GFYPGNTT-VTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFTYALE 1913
G NTT V I + C ++I + C P G G V ++I V+ + Y + Y
Sbjct: 1597 GLRGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGN-GSVALEIEVDGLWYHIGVIGYNKA 1655
Query: 1914 DTPFLRGIIPSRGPPGTEI-EITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDH 1972
TP L I S + +I+G+ I + I C N +V+QC+V
Sbjct: 1656 FTPELISISQSDDILTFAVAQISGA------ANIDIFIGMSPCVGVSGNHTVLQCVVPSL 1709
Query: 1973 AGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIIL 2032
G + V + +G A S +VF + I + + G GG + + V G GF+P N
Sbjct: 1710 PAGEYHVRGYDCIRGWASSALVFTSRVIITAVTENFGCLGG-RLVHVFGAGFSPGNVSAA 1768
Query: 2033 VCGSECAI--DRLRSDYTTL----------LCEIPSNNGTGAEQA------CEVSVVNGK 2074
VCG+ C + + S ++ L LC + + E A C+++V
Sbjct: 1769 VCGAPCRVLANATVSAFSCLVLPLDVSLAFLCGLKREEDS-CEAARHTYVQCDLTVAMAT 1827
Query: 2075 DLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDV 2134
+ P+ Y + V A + G S +E + I + C++
Sbjct: 1828 EQLLESWPYLYICEESSQCLFVPDH---WAESMFPSFSGLFISPKLERDEVLIYNSSCNI 1884
Query: 2135 EYSNKTHIICMTDAHTLSGWAPVCVHIRGV----GMAKLDNADFLYVDAWSSNFSWGGKS 2190
+ + C T P+ V I + G N + WS SW +
Sbjct: 1885 TMETEAEMECETPNQ------PITVKITEIRKRWGQNTQGNFSLQFCRRWSRTHSWFPER 1938
Query: 2191 PPEEGSLVVITKGQTILLDQSTPILKMLLIQGGTLIF-DEADIELQAENILITDGGVLQI 2249
P++G V + GQ +LLD +T IL +L I+GG LIF IEL+A IL++DGG L+I
Sbjct: 1939 LPQDGDNVTVENGQLLLLDTNTSILNLLHIKGGKLIFMAPGPIELRAHAILVSDGGELRI 1998
Query: 2250 GTETSPFQHKAVITLHGHLRSPELPVYGAKTLAVREGILDLHGVPVPVTWTRLAHTAKAG 2309
G+E PFQ +A ITL+G S YG K LAVR G L LHG V T L TA A
Sbjct: 1999 GSEDKPFQGRAQITLYGSSYSTPFFPYGVKFLAVRNGTLSLHGSLPEVIVTCLRATAHAL 2058
Query: 2310 ERILILQEAVTWKPGDNIVIAS-TGHRHSQGENEKMTIASVSADGINITLSNPLNYTHLG 2368
+ +L L++AV W PGD +VI S TG + ++ E +T+ +V ++ L +PL Y+H
Sbjct: 2059 DTVLALEDAVDWNPGDEVVIISGTGVKGAKPMEEIVTVETVQ--DTDLYLKSPLRYSH-N 2115
Query: 2369 ITVTLPDGTLFEARAEVGILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKF 2428
T G +A V +L+R+I I+G+ E + +C + + E Q CL
Sbjct: 2116 FTENWVAGEHHILKATVALLSRSITIQGNLTNEREKLLVSCQEA-NAPEGNLQHCLYSMS 2174
Query: 2429 GEEIGSDQFGGCVMFHAPVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKS 2488
+ +GS G V+ + + V +++ V+ GQAF ++ L+G ++ +S
Sbjct: 2175 EKMLGSRDMGARVIVQSFPEEPSQV--QLKGVQFQVLGQAFH--KHLSSLTLVGAMR-ES 2229
Query: 2489 YVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFI------------------ED 2530
+++GC + +++R +++ T L V+ N+ Y+I G A + +D
Sbjct: 2230 FIQGCTVRNSFSRGLSMCGTLGLKVDSNVFYNILGHALLVGTCTEMRYISWEAIHGRKDD 2289
Query: 2531 GIEHGNILQYNLAVFVQQSTSLLNDDV-TPAAFWVTNPNNTIRHNAVAGGTHFGFWYRMN 2589
HGNI++ N+ + V + L N ++ TP+ ++ +P N I N V G + F++ M
Sbjct: 2290 WSGHGNIIRNNVIIQVSGAEGLSNPEMLTPSGIYICSPTNVIEGNRVCGAGYGYFFHLMT 2349
Query: 2590 NHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMWIFEEYFPMQTGSCTSTVPAPAIFN 2649
N + PL F N HS +G++++ ++ P V +F
Sbjct: 2350 NQTS-----------QAPLLSFTQNIAHSCTRYGLFVYPKFQPPW-----DNVTGTTLFQ 2393
Query: 2650 SLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIETKRILAPYVGGWGETNGAVIKNAKI 2709
S T W GA+ L+ NF + + + GI+ + N +V ++ +
Sbjct: 2394 SFTVWESAGGAQIFRSSNLRLKNFKVYSCRDFGIDVLE---------SDANTSVT-DSLL 2443
Query: 2710 VGHLDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMNFDRPNCVALGVTSISGVCNDRCGG 2769
+GH G + C + G+ P L VS+ F+NFD NCVA+ S C+ GG
Sbjct: 2444 LGHFAHKG---SLCMSSGIKTPKRWELMVSNTTFVNFDLINCVAIRTCSD---CSQGQGG 2497
Query: 2770 WSAKFVDVQYSHTPNKAGFRWEHEMVMIDVDGSLTGHKGHTVIPHSSLLDPSHCTQEAEW 2829
++ K ++++++ N F + H ++ D+DGSL+G ++ L S C + +
Sbjct: 2498 FTVKTSQLKFTNSSNLVAFPFPHAAILEDLDGSLSGKNRSHILASMETLSAS-CLVNSSF 2556
Query: 2830 SIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLSDSFG-TSIIPFQKKRLTHMSGWMA 2888
GS C V FHR++ + + D+ ++DS T+ + + + L++ GWMA
Sbjct: 2557 GRVVHGSACGGGVLFHRMSIGLANTPEV-SYDLTMTDSRNKTTTVNYVRDTLSNPRGWMA 2615
Query: 2889 LIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVIISH-NFTQNPDMFNIIDMRNGSS 2947
L+ + + + + ++ Y++TF F +Y+++ H + PD+ R G S
Sbjct: 2616 LLLDQETYSLQSENLWINRSLQYSATFDNFAPGNYLLLVHTDLPPYPDILLRCGSRVGLS 2675
Query: 2948 NPLNWNTSKNG--DWHLEANTSTLYYLVSGRNDLHQSQLISGNLDPDVKDVVINFQAYCC 3005
P + +N DW + L YLVSG + + + P +
Sbjct: 2676 FPFLPSPGQNQGCDWFFNSQLRQLTYLVSGEGQVQVILRVKEGMPPTIS----------- 2724
Query: 3006 ILQDCFPVHPPSRKPIPKKRPATYNLWSNDSFWQSSREN----NYTVPHPGANVIIPEGT 3061
P + WS WQ E N T+P PG +V+I
Sbjct: 2725 ---------------ASTSAPESALKWSLPETWQGVEEGWGGYNNTIPGPGDDVLILPNR 2769
Query: 3062 WIVADIDMPSMERLIIWGVLELE-DKYNVGAAESSYREVVLNATYISLQGGRLIGGWEDN 3120
++ D D+P + L + G L+ D+ NV L+ + + GG L G +N
Sbjct: 2770 TVLVDTDLPFFKGLYVMGTLDFPVDRSNV-----------LSVACMVIAGGELKVGTLEN 2818
Query: 3121 PFKGDLK--IVLRGNHTTQDWALPEGPNQGAKVLGVFGELDLHGIPHSIYKTKLSETAFA 3178
P + + K I+LR + + G + +GV+G++ L+ T L +
Sbjct: 2819 PLEKEQKLLILLRASEGVFCDRM-NGIHIDPGTIGVYGKVHLYSAYPKNSWTHLGADIAS 2877
Query: 3179 GSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKILILNDSLSYTHFAEK 3238
G++ + + DAVDW+ ++IV++++SY+ H+ E ++ ++ H + + + L + H
Sbjct: 2878 GNERIIVEDAVDWRPHDKIVLSSSSYEPHEAEVLTVKEVKGHH--VRIYERLKHRHIGS- 2934
Query: 3239 YHVPGTGESYTLAADVGILSRNIKIVGEDYPGWSEDSFGARVLVGSFTENMMT-FKGNAR 3297
HV G LAA+VG+L+RNI+I + S R+ VGSF ++ F G +
Sbjct: 2935 VHVTEDGRHIRLAAEVGLLTRNIQIQ-------PDVSCRGRLFVGSFRKSSREEFSGVLQ 2987
Query: 3298 ISNVEFYHSGQEGFRDSTDPRYA-VTFLNLGQIQEHGSSYIRGCAFHHGFSPAIGVFGTD 3356
+ NVE + G P Y+ V F N+ S+I H I +
Sbjct: 2988 LLNVEIQNFGS--------PLYSSVEFSNVS-----AGSWIISSTLHQSCGGGIHAAASH 3034
Query: 3357 GLDIDDNIIHFTVGEGIRIWGNANRVRGNLIALSVWPGTYQNRKDLSSTLWHAAIEINRG 3416
G+ ++DNI+ T G GI + G A V NL+ L P ST+W A I++N+
Sbjct: 3035 GVLLNDNIVFGTAGHGIDLEGQAYTVTNNLVVLMTQPAW--------STIWVAGIKVNQV 3086
Query: 3417 TNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLYGIYM-NQDGLPGCSL 3475
+ L NVVAG R G+ I G C + W DN AH L+G+++ + GL C+
Sbjct: 3087 KDINLHGNVVAGSERLGFHIRGHKCS---SCELLWSDNVAHSSLHGLHLYKESGLDNCTR 3143
Query: 3476 IQGFTIWTCWDYGIYFQTTESVHIYNVTLVDNGMAIFPMIYMPAAISHKISSKNVQIKSS 3535
I GF + +DYG SV I N+TLVDN + + ++Y+ +A + + + +++S
Sbjct: 3144 ISGFLAFKNFDYGAMLHVENSVEIENITLVDNTIGLLAVVYVFSAPQNSVKKVQIVLRNS 3203
Query: 3536 LIVGSSPGFNC-SDVLTNDDPNIELTAAHRSPRSPSGGRSGICWPTFASAHNMAPRKPHA 3594
+IV +S F+C D + N LT+ R+P +P GGR GI WP F S N P++P
Sbjct: 3204 VIVATSSSFDCIQDKVKPHSAN--LTSTDRAPSNPRGGRIGILWPVFTSEPNQWPQEPWH 3261
Query: 3595 GIMSYNAISGLLDISGSTFVGFKNVC-SGETNVIFITNPLNEDLQHPIHVKNIKLVDTTE 3653
+ + ++ISG++ + TF F C S + +V + N N + HPI + +++ +
Sbjct: 3262 KVRNDHSISGIMKLQDVTFSSFVKSCYSDDLDVCILPNAENSGIMHPITAERTRMLKIKD 3321
Query: 3654 QSKIFI----HRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLG--NAGSVIPQAEYEW 3707
++K + R D+ KV C ++ C + RK +D+DG LG SV P+ E EW
Sbjct: 3322 KNKFYFPSLQPRKDLGKV---VCPELDCASPRKYLFKDLDGRALGLPPPVSVFPKTEAEW 3378
Query: 3708 DGNSQVGIGDYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEWQSYQCFGMEYA 3767
+F N +K C Y Q + C +
Sbjct: 3379 TA----------------SFFNAGTFREEQK-----------CTYQFLMQGFICKQTDQV 3411
Query: 3768 MMVIESLDPDTETRRLSPVAIMGNGYVDLINGPQDHGWCAGYTCQRRLSLFHSIVALNKS 3827
+++++S D ++L PV + +G+VD+ + + C + +S F+SI+ + +
Sbjct: 3412 VLILDSADAIWAIQKLYPVVSVTSGFVDVFSSVNANIPC---STSGSVSTFYSILPIRQI 3468
Query: 3828 YEVYFTGTSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNLLVCPKTTIWNAQQKH 3887
+V F +PQ LR LL +L+ +F+ LQ V++ + P T + +A
Sbjct: 3469 TKVCFMDQTPQVLRFFLLGNKSTSKLLLAVFYHELQSPHVFLGESFI-PPTLVQSASL-- 3525
Query: 3888 CELNNHLYKDQFLPNLDSTVLGENYFDGTYQMLYLLVKGTIPVEIHTATVIFVSFQLSVA 3947
L + +G NYF+ +LY++++G P+EI + I ++ + V+
Sbjct: 3526 ---------------LLNESIGANYFNIMDNLLYVVLQGEEPIEIRSGVSIHLALTVMVS 3570
Query: 3948 TEDDFYTSHNLVKNLALFLKIPSDKIR-----------ISKIRGKSLRRKR--------- 3987
+ + +++ L FL+I ++IR + I +RKR
Sbjct: 3571 VLEKGW-EIVILERLTNFLQIGQNQIRFIHEMPGHEETLKAIADSRAKRKRNCPTVTCTS 3629
Query: 3988 ---------------------------SMGFIIEIEIGDPPIQFISNGTTGQMQLSELQE 4020
++ +I IEIGD P S G + ++LQ
Sbjct: 3630 HYRRVGQRRPLMMEMNSHRASPPMTVETISKVIVIEIGDSP-TVRSTGMISSLSSNKLQN 3688
Query: 4021 IAGSLGQAVILGNISSILGFNISSMSITNPLPSPSDSGWIKVTAQPVERSAFPVHHVAFV 4080
+A + A G + ++L I ++ +T K S+F ++ ++
Sbjct: 3689 LAHRVITAQQTGVLENVLNMTIGALLVTQS----------KGVIGYGNTSSFKTGNLIYI 3738
Query: 4081 S--SLLVITQPVAAQPGQPFPQQPSVKATDSDGNCV-SVGITA--LTLRAILKDSNNNQV 4135
+L ++ QP + G P QP + D V S+G + T+ A L+ ++++
Sbjct: 3739 RPYALSILVQPSDGEVGNELPVQPQLVFLDEQNRRVESLGPPSEPWTISASLEGASDSV- 3797
Query: 4136 NGLSGNTTIPFSSCWANYTDLTPLRTGKNYKIEFILDNVVGV----ESRTFSLLAESVSS 4191
L G T + ++ +L L +G N+ F + + GV S+ F++L +
Sbjct: 3798 --LKGCTQAETQDGYVSFYNLAVLISGSNWHFIFTVTSPPGVNFTARSKPFAVLPVTRKE 3855
Query: 4192 SGSSSSSNSKASTVGTYAQIMTVVISCLV 4220
+ + S +S A +SCLV
Sbjct: 3856 KSTIILAASLSSVASWLA------LSCLV 3878
Score = 257 bits (656), Expect = 2e-67
Identities = 319/1323 (24%), Positives = 536/1323 (40%), Gaps = 183/1323 (13%)
Query: 637 FTLNWDGIASKPLTLWSSEAEFQGAVEEMVSTKCP--PQIAN------FEEGFVVKYFRD 688
F L WD ++S+P+ ++ Q +EE+++ KC P +N FE G V
Sbjct: 514 FFLTWDNVSSQPIPANATAHLIQTTIEELLAVKCKLEPLWSNILLRLGFERGPEVSN--- 570
Query: 689 YETDFNLEHINRGQKTAETDAYCGRYSLKNPA--VLFDSADVKPNRRPYGDILLFPYNQL 746
+ G T+ T+ +CGR+SL+ P VL A K R L Y L
Sbjct: 571 ----------SDGDLTSGTEPFCGRFSLRQPRHLVLTPPAAQKGYR-------LDQYTHL 613
Query: 747 CLAYKGFLANYIGLKFQYQDN-SKITRSTDTQFTYNFAYGNNWTYTCIDLLDL------- 798
CLAYKG + + + + + ++T ++ +W + C DL +
Sbjct: 614 CLAYKGHMNKILKMIVSFTIGFQNMVKNTTCDWSLTRTSPESWQFDCTDLWETCVRCFGD 673
Query: 799 VRTKYTGTNVSLQRISLHK-ASESQSFYVDVVYIGHTS-TISTLDEMPKRRLPALANKGI 856
++ + V + +I+L A E+ FYVD + I T+ T+S D R G
Sbjct: 674 LQPPPANSPVLVHQINLLPLAQETGLFYVDEIIIADTNVTVSQADSGTARP------GGN 727
Query: 857 FLEHFQVNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNW 916
+E V P + YSVT C +P++ + T TE
Sbjct: 728 LVESVSV----VGSPPV---YSVTSWLAGCGTELPLITAR--SVPTEGTEEG-------- 770
Query: 917 PGESKIHIQRIQAASPPLSGSFDIQAYGHILKGLPAAVSAADLQFALQSLE--------G 968
G + QR Q SPPL G F IQ ++ +P +SA L LQ+
Sbjct: 771 SGLVLVTTQRRQRTSPPLGGHFRIQLPNTVISDVPVQISAHHLHQLLQNNADDFTSRYLN 830
Query: 969 MGRISVTRE-GTCAGYAWNIKWRSTCGK-QNLLQINDSNIIGEKANMTVTRIKEGGLFRQ 1026
+V + TC + W + W + G N ++++D N+ G + +GG+F
Sbjct: 831 ASDFTVKEDLYTCYEHVWTLSWSTQIGDLPNFIRVSDENLTGVNPAAATRVVYDGGVFLG 890
Query: 1027 HVLGDLLRTPSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYEEGTILT 1086
+ GD+L T +Q QV V VN +PA C G C F + TP V ++ S + ++
Sbjct: 891 PIFGDMLATANQHTQVVVRVNDVPAHCPGSCSFQYLQGSTPCVHSVWYSIDG-DINLMIY 949
Query: 1087 IVGSGFS-PSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQNVG 1145
I G+GFS S + V+V C ++ ++ + CQ G + + + GLA +
Sbjct: 950 ITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGLAISAT 1009
Query: 1146 GEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNETC--NVIEGDLNRI 1203
GE+ + + ++ + P + GG T+ G S +L G+ +C NV + +RI
Sbjct: 1010 GEDLFLNVKPRLDMVEPSRAADIGGLWATIRGSSLEGVSLILFGSYSCAINVATSNSSRI 1069
Query: 1204 TCRTPK--KTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIK 1261
C+ P K V+++V + A AF+Y P+I S + I G L I
Sbjct: 1070 QCKVPPRGKDGRIVNVTVIRGDYSAVLPRAFTYVSSLNPVIVTLSRNISNIAGGETLVIG 1129
Query: 1262 GYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFASTRDK 1321
N ++ V+V + + + LP L G H I V + G +
Sbjct: 1130 VARLMNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSIN--GVSIHSQG 1187
Query: 1322 LNSSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVI 1381
++ IQY+ EV S+ P GSL GGT ++I G GFS PA VL+G+ C++ + +E I
Sbjct: 1188 VDLHIQYLTEVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASI 1247
Query: 1382 KCILHSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLRGIGYRIFS 1441
C T +I + G +V W+ G R F+
Sbjct: 1248 WC---ETLPAPQIPDAGAPTVPAAVEVWA-------------------------GNRFFA 1279
Query: 1442 VSSPGSVIYDGKGFTSGRQKSTS---GSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVINV 1498
S++ GKGFT + + + + + T+ + + G + ++S+ L G +N
Sbjct: 1280 RGPSPSLV--GKGFTFMYEAAATPVVTAMQGEITNSSLSLHVGG-SNLSNSVILLGNLNC 1336
Query: 1499 LPAETRHIPLHLFVGRSEATYAYGGPENLHLGSSVAGCLATEPLCSLN----NTRVKNSK 1554
T ++ G S++GC + PL SL +V+ +
Sbjct: 1337 ----------------DVETQSFQG------NVSLSGC--SIPLHSLEAGIYPLQVRQKQ 1372
Query: 1555 RLLFEVSSCFS-----PSISNITPSTGTV--NELITIIGHGFSNLPWANKVTI-GSYPCV 1606
+S P I I PS G+ ++T+ G ++ + +V + G + CV
Sbjct: 1373 MGFANMSVVLQQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCV 1432
Query: 1607 VEESSEDSITCHIDPQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRRFVLL------PN 1660
+ + +I C + + G ++ +TV +N L++E L P
Sbjct: 1433 ILSLGDHTILCQVSLEGDPLPGASFSLNVTV-----LVNGLTSECQGNCTLFIREEASPV 1487
Query: 1661 IDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLM-GHFPCKVLSVNYTAIECETSPAAQ 1719
+D + N + +T+V I+G A ++ V + PC V N + + C+T A
Sbjct: 1488 MDALSTNTSGS--LTTVLIRGQRLATTADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAP 1545
Query: 1720 QLVDVDLLIHGVPAQCQGNCTFSYLESITPYITGVFPN--SVIGSVKVLIEGEGLGTVLE 1777
+ + C GN + + I P + FP S+ G + IEG GL
Sbjct: 1546 GPHYLSVFYTRNGYACSGNVSRHFY--IMPQVFHYFPKNFSLHGGSLLTIEGTGL-RGQN 1602
Query: 1778 DIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGL-----ALGNLTVSSPP 1832
+V+I Q + + I +V P G+ SV++ + GL +G +P
Sbjct: 1603 TTSVYIDQQTCLTVNIGAELIRCIV---PTGNGSVALEIEVDGLWYHIGVIGYNKAFTPE 1659
Query: 1833 VASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEPCQIISINPNEVYCRTPAGTTGMV 1892
+ S+S + + T V +G N + IG PC +S N + C P+ G
Sbjct: 1660 LISISQSDDIL---TFAVAQISG--AANIDIFIGMSPCVGVSGNHTVLQCVVPSLPAGEY 1714
Query: 1893 DVK 1895
V+
Sbjct: 1715 HVR 1717
Score = 188 bits (477), Expect = 1e-46
Identities = 156/540 (28%), Positives = 244/540 (45%), Gaps = 64/540 (11%)
Query: 5 WLLGIWGLCGLLLCAADPSTDGSQIIPKVTEIIPKYGSINGATRLTIRGEGFSQANQFNY 64
WL+ + + LLL S I P+ GS+ G T +T+ +G +
Sbjct: 4 WLISLMSIEVLLLAVRHLSL----------HIEPEEGSLAGGTWITVIFDGLELGVLYPN 53
Query: 65 GVDNAE--LGNSVQLISSFQSITCDVEKDASHSTQITCYTRAMPEDS----YTVRVSVDG 118
E L N ++ + +S+ CDV +TC TR++ ++ Y + G
Sbjct: 54 NGSQLEIHLVNVNMVVPALRSVPCDVFPVFLDLPVVTCRTRSVLSEAHEGLYFLEAYFGG 113
Query: 119 VPVTENNTCKGHINSWECTFNAKSFRTPTIRSITPLSGTPGTLITIQGRIFT-------- 170
V+ N G +S CTF +TP + + P SG PG LI + G I T
Sbjct: 114 QLVSSPNP--GPRDS--CTFKFSKAQTPIVHQVYPPSGVPGKLIHVYGWIITGRLETFDF 169
Query: 171 --DVYGSNIALSSNGKNVRILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTT 228
+ S + L + G PC L+ Q + Y ++ DH +G++ C
Sbjct: 170 DAEYIDSPVILEAQGDK--------WVTPCSLINRQMGSCYPIQEDH---GLGTLQCHVE 218
Query: 229 GTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLNKIAMFQTYAEVTMIFPSQGSIRGGTTL 288
G +IG NVSF + N G+S K A+ +S+ + ++QT++E+ +FP GS+ G T +
Sbjct: 219 GDYIGSQNVSFSVFNK-GKSMVHKKAWLISAKQDLFLYQTHSEILSVFPETGSLGGRTNI 277
Query: 289 TISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKT--PPKPHILKTVYPGGRGLKLEV 346
TI+G FFD + +V + G PCDI +V+ I C T P K L T PG RGL EV
Sbjct: 278 TITGDFFDNS---AQVTIAGIPCDIRHVSPRKIECTTRAPGKDVRLTTPQPGNRGLLFEV 334
Query: 347 WNNSRPIRLEEILEYNEKTPGYMGASWVDSASYI--WLMEQDTFVARFSGFLVAPDSDVY 404
+ E LE E TPGY +++S W E F AR SGF VAP+++ Y
Sbjct: 335 GD------AVEGLELTEATPGYRWQIVPNASSPFGFWSQEGQPFRARLSGFFVAPETNNY 388
Query: 405 RFYIKGDDRYAIYFSQTGLPEDKVRIAYHSANANSYFSSPTQRSDD---------IHLQK 455
F+I+ D + +++FS + P KV++A S +F S Q D+ + L
Sbjct: 389 TFWIQADSQASLHFSWSEEPRTKVKVASISVGTADWFDSWEQNRDEGTWQQKTPKLELLG 448
Query: 456 GKEYYIEILLQEYRLSAFVDVGLYQYRNVYTEQQTGDAVNEEQVIKSQSTILQEVQVITL 515
G YY+E S + +G+ + + E+ I+ ++ L EVQV+ +
Sbjct: 449 GAMYYLEAEHHGIAPSRGMRIGVQIHNTWLNPDVVTTYLREKHQIRVRAQRLPEVQVLNV 508
Score = 123 bits (308), Expect = 4e-27
Identities = 156/622 (25%), Positives = 262/622 (42%), Gaps = 74/622 (11%)
Query: 1576 GTVNELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNSMDVGIRETVTL 1635
G +N +I I G GFS +VT+ C V S++ ++ C D + VG+ + +
Sbjct: 942 GDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTD---LLPVGMHR-ILM 997
Query: 1636 TVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVK-VL 1694
V G AI+ D + P +D+V P+ + G TI+GS S GV +L
Sbjct: 998 LVRPSGLAISATGE--DLFLNVKPRLDMVEPSRAADIGGLWATIRGS----SLEGVSLIL 1051
Query: 1695 MGHFPC--KVLSVNYTAIECETSPAAQ--QLVDVDLLIHGVPAQCQGNCTFSYLESITPY 1750
G + C V + N + I+C+ P + ++V+V ++ A F+Y+ S+ P
Sbjct: 1052 FGSYSCAINVATSNSSRIQCKVPPRGKDGRIVNVTVIRGDYSAVLPR--AFTYVSSLNPV 1109
Query: 1751 ITGVFPN-SVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNEN--NITALVTPLPV 1807
I + N S I + L+ G D+ V + Q A ++ + + PLP
Sbjct: 1110 IVTLSRNISNIAGGETLVIGVARLMNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPA 1169
Query: 1808 GHHSVSVVVG-----SKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFY--PGN 1860
G H +SV + S+G+ L ++ V S+ P GS+ GGT L I+G GF P
Sbjct: 1170 GLHRISVSINGVSIHSQGVDLHIQYLTE--VFSIEPCCGSLLGGTILSISGIGFSRDPAL 1227
Query: 1861 TTVTIGDEPCQIISINPNEVYCRT--------------PAGTTGMVDVKIFVN----TIA 1902
V +G+ C I+++ ++C T PA + F ++
Sbjct: 1228 VWVLVGNRSCDIVNLTEASIWCETLPAPQIPDAGAPTVPAAVEVWAGNRFFARGPSPSLV 1287
Query: 1903 YPPLLFTYALEDTPFLRGIIPSRGPPGTEIEITGSNFGFEILEISVMINNIQCNVT---- 1958
F Y TP + + + + GSN + +++ N+ C+V
Sbjct: 1288 GKGFTFMYEAAATPVVTAMQGEITNSSLSLHVGGSNLSNSV----ILLGNLNCDVETQSF 1343
Query: 1959 MANDSVVQCIVGDHA--GGTFPVMMHHKTKGSAMSTVV---FEYPLNIQNINPSQGSFGG 2013
N S+ C + H+ G +P+ + K G A +VV F I I PSQGS G
Sbjct: 1344 QGNVSLSGCSIPLHSLEAGIYPLQVRQKQMGFANMSVVLQQFAVMPRIMAIFPSQGSACG 1403
Query: 2014 GQTMTVTGTGFNPQNSIILVCGS---ECAIDRLRSDYTTLLCEIPSNNG--TGAEQACEV 2068
G +TV G N + + V S C I L T+LC++ GA + V
Sbjct: 1404 GTILTVRGLLLNSRRRSVRVDLSGPFTCVILSLGDH--TILCQVSLEGDPLPGASFSLNV 1461
Query: 2069 SV-VNG-KDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGG-TRLTVVGSGFSENMEDVHI 2125
+V VNG Q +P++ A+S +T+G T + + G + ++ +
Sbjct: 1462 TVLVNGLTSECQGNCTLFIREEASPVMDALST---NTSGSLTTVLIRGQRLATTADEPMV 1518
Query: 2126 TI-AEAKCDVEYSNKTHIICMT 2146
+ + C+V + N +H++C T
Sbjct: 1519 FVDDQLPCNVTFFNASHVVCQT 1540
Score = 89.4 bits (220), Expect = 7e-17
Identities = 123/544 (22%), Positives = 214/544 (39%), Gaps = 71/544 (13%)
Query: 1577 TVNELITIIGHGFSNLPWANKVTIGSYPCV------VEESSEDSIT-CHIDPQNSMDVGI 1629
++N +I + SN+ + IG + VE +D++ H ++V +
Sbjct: 1105 SLNPVIVTLSRNISNIAGGETLVIGVARLMNYTDLDVEVHVQDALAPVHTQSAWGLEVAL 1164
Query: 1630 RETVTLTVYNLGTAINTLS---NEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIKGSGFAV 1686
+ ++ + +IN +S D L + + P GS G T ++I G GF+
Sbjct: 1165 -PPLPAGLHRISVSINGVSIHSQGVDLHIQYLTEVFSIEPCCGSLLGGTILSISGIGFSR 1223
Query: 1687 SSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVPAQCQ---GN----- 1738
A V VL+G+ C ++++ +I CET PA Q D VPA + GN
Sbjct: 1224 DPALVWVLVGNRSCDIVNLTEASIWCETLPAPQ---IPDAGAPTVPAAVEVWAGNRFFAR 1280
Query: 1739 ----------CTFSYLESITPYITGVFPNSVIGSVKVLIEGEG-------LGTVLEDIAV 1781
TF Y + TP +T + S+ + + G LG + D+
Sbjct: 1281 GPSPSLVGKGFTFMYEAAATPVVTAMQGEITNSSLSLHVGGSNLSNSVILLGNLNCDVET 1340
Query: 1782 --FIGNQQFRAIEVNENNITALVTPLPV-----GHHSVSVVVGSKGLALGNLTVSSPPVA 1834
F GN + +++ A + PL V G ++SVV+ + P +
Sbjct: 1341 QSFQGNVSLSGCSIPLHSLEAGIYPLQVRQKQMGFANMSVVLQQFAV--------MPRIM 1392
Query: 1835 SLSPTSGSIGGGTTLVITGNGFYPGNTTVTI---GDEPCQIISINPNEVYCRTP------ 1885
++ P+ GS GGT L + G +V + G C I+S+ + + C+
Sbjct: 1393 AIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCVILSLGDHTILCQVSLEGDPL 1452
Query: 1886 AGTTGMVDVKIFVNTI---AYPPLLFTYALEDTPFLRGIIPSRGPPGTEIEITGSNFGFE 1942
G + ++V + VN + E +P + + + T + I G
Sbjct: 1453 PGASFSLNVTVLVNGLTSECQGNCTLFIREEASPVMDALSTNTSGSLTTVLIRGQRLATT 1512
Query: 1943 ILEISVMINN-IQCNVTMANDSVVQCIVGDHAGGTFPVMMHHKTKGSAMSTVV---FEYP 1998
E V +++ + CNVT N S V C D A G + + + G A S V F
Sbjct: 1513 ADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAPGPHYLSVFYTRNGYACSGNVSRHFYIM 1572
Query: 1999 LNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNN 2058
+ + P S GG +T+ GTG QN+ + + + + + C +P+ N
Sbjct: 1573 PQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYIDQQTCL-TVNIGAELIRCIVPTGN 1631
Query: 2059 GTGA 2062
G+ A
Sbjct: 1632 GSVA 1635
Score = 88.2 bits (217), Expect = 2e-16
Identities = 114/488 (23%), Positives = 201/488 (41%), Gaps = 45/488 (9%)
Query: 1718 AQQLVDVDLLIHGVPAQCQGNCTFSYLESITPYITGVFPNSVIGSVKVL--IEGEGLGTV 1775
A Q V + ++ VPA C G+C+F YL+ TP + V+ S+ G + ++ I G G
Sbjct: 900 ANQHTQVVVRVNDVPAHCPGSCSFQYLQGSTPCVHSVW-YSIDGDINLMIYITGTGFSGD 958
Query: 1776 LEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALG----NLTVS-S 1830
+ + V + + I N+ N+ LPVG H + ++V GLA+ +L ++
Sbjct: 959 SQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGLAISATGEDLFLNVK 1018
Query: 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEPC--QIISINPNEVYCRT-PAG 1887
P + + P+ + GG I G+ G + + G C + + N + + C+ P G
Sbjct: 1019 PRLDMVEPSRAADIGGLWATIRGSSL-EGVSLILFGSYSCAINVATSNSSRIQCKVPPRG 1077
Query: 1888 TTG-MVDVKIFVNTI-AYPPLLFTYALEDTPFL----RGIIPSRGPPGTEIEITGSNFGF 1941
G +V+V + A P FTY P + R I G I + +
Sbjct: 1078 KDGRIVNVTVIRGDYSAVLPRAFTYVSSLNPVIVTLSRNISNIAGGETLVIGV-ARLMNY 1136
Query: 1942 EILEISVMINNIQCNVTMANDSVVQCIVGDHAGG--TFPVMMHHKTKGSAMSTVVFEYPL 1999
L++ V + + V + ++ + G V ++ + S + +Y
Sbjct: 1137 TDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQGVDLHIQYLT 1196
Query: 2000 NIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCE------ 2053
+ +I P GS GG ++++G GF+ +++ V + D + ++ CE
Sbjct: 1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQ 1256
Query: 2054 IPSNNGTGAEQACEVSVVN---GKDLSQSMT----PFTYAVSLTPLITAVSPKRGSTAGG 2106
IP A EV N + S S+ F Y + TP++TA+ + T
Sbjct: 1257 IPDAGAPTVPAAVEVWAGNRFFARGPSPSLVGKGFTFMYEAAATPVVTAMQGE--ITNSS 1314
Query: 2107 TRLTVVGSGFSENMEDVHITIAEAKCDVE----YSNKTHIICMTDAHTL-SGWAPVCVHI 2161
L V GS S ++ I + CDVE N + C H+L +G P+ V
Sbjct: 1315 LSLHVGGSNLSNSV----ILLGNLNCDVETQSFQGNVSLSGCSIPLHSLEAGIYPLQVRQ 1370
Query: 2162 RGVGMAKL 2169
+ +G A +
Sbjct: 1371 KQMGFANM 1378
Score = 77.0 bits (188), Expect = 4e-13
Identities = 82/356 (23%), Positives = 149/356 (41%), Gaps = 32/356 (8%)
Query: 1030 GDLLRTPSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYEEGTILTIVG 1089
GD L S V V VNG+ ++C G+C +P++ A+S + G++ T++
Sbjct: 1449 GDPLPGASFSLNVTVLVNGLTSECQGNCTLFIREEASPVMDALSTN----TSGSLTTVLI 1504
Query: 1090 SG----FSPSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQNVG 1145
G + + + C++ + + CQ + + G ++V G A + G
Sbjct: 1505 RGQRLATTADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAPGPHYLSVFYTRNGYACS-G 1563
Query: 1146 GEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGF--NENSKVLVGNETCNVIEGDLNRI 1203
+F Q+ H +P + S+ GG+LLT+ G G + V + +TC + I
Sbjct: 1564 NVSRHFYIMPQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYIDQQTCLTVNIGAELI 1623
Query: 1204 TCRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGY 1263
C P G+V + + +G YN TP + S + IL I G
Sbjct: 1624 RCIVP-TGNGSVALEIEVDGLWYHI-GVIGYNKAFTPELISIS-QSDDILTFAVAQISG- 1679
Query: 1264 NFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDI--YVEVRNWGFASTRDK 1321
N+ +++G C + N T ++C++P L G++ + Y +R W ++
Sbjct: 1680 ------AANIDIFIGMSPCVGVSGNHTVLQCVVPSLPAGEYHVRGYDCIRGWASSAL--- 1730
Query: 1322 LNSSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSS 1377
+ +S + VT F GG + + G GFS P + + PC V +++
Sbjct: 1731 VFTSRVIITAVTENF----GCLGGRLVHVFGAGFS--PGNVSAAVCGAPCRVLANA 1780
Score = 59.3 bits (142), Expect = 8e-08
Identities = 38/85 (44%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 267 QTYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTP 326
Q EV I P GS+ GGT L+ISG F + V VLVG CDI+N+TE SI C+T
Sbjct: 1193 QYLTEVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETL 1252
Query: 327 PKPHILKTVYPGGRGLKLEVWNNSR 351
P P I P +EVW +R
Sbjct: 1253 PAPQIPDAGAPTVPA-AVEVWAGNR 1276
Score = 47.4 bits (111), Expect = 3e-04
Identities = 110/460 (23%), Positives = 166/460 (36%), Gaps = 98/460 (21%)
Query: 1842 SIGGGTTLVI--TGNGFYPGNT--TVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIF 1897
SI G L+I TG GF + VT+ C++I N V C+T GM + +
Sbjct: 939 SIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILML 998
Query: 1898 VNT--IAYPPLLFTYALEDTPFLRGIIPSRGPP--GTEIEITGSNFGFEILEISVMINNI 1953
V +A L P L + PSR G I GS+ L ++ +
Sbjct: 999 VRPSGLAISATGEDLFLNVKPRLDMVEPSRAADIGGLWATIRGSSLEGVSL---ILFGSY 1055
Query: 1954 QC--NVTMANDSVVQCIVGDHA------------GGTFPVMMHHKTKGSAMSTVVFEYPL 1999
C NV +N S +QC V G V+ T S+++ V+
Sbjct: 1056 SCAINVATSNSSRIQCKVPPRGKDGRIVNVTVIRGDYSAVLPRAFTYVSSLNPVIVTLSR 1115
Query: 2000 NIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTL--------- 2050
NI NI GG+T+ + + RL + YT L
Sbjct: 1116 NISNI-------AGGETLVI-------------------GVARLMN-YTDLDVEVHVQDA 1148
Query: 2051 LCEIPSNNGTGAEQAC--------EVSV-VNGKDLSQSMTPFTYAVSLTPLITAVSPKRG 2101
L + + + G E A +SV +NG + + + ++ P G
Sbjct: 1149 LAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQGVDLH--IQYLTEVFSIEPCCG 1206
Query: 2102 STAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVHI 2161
S GGT L++ G GFS + V + + CD+ + I C T AP I
Sbjct: 1207 SLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLP------AP---QI 1257
Query: 2162 RGVGMAKLDNADFLYVDAWSSN-FSWGGKSPPEEGSLVVITKGQTILLD-QSTPILKMLL 2219
G + A V+ W+ N F G SP ++ KG T + + +TP++ +
Sbjct: 1258 PDAGAPTVPAA----VEVWAGNRFFARGPSPS------LVGKGFTFMYEAAATPVVTAMQ 1307
Query: 2220 --IQGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQ 2257
I +L L IL+ G L ET FQ
Sbjct: 1308 GEITNSSLSLHVGGSNLSNSVILL---GNLNCDVETQSFQ 1344
Score = 46.6 bits (109), Expect = 5e-04
Identities = 36/131 (27%), Positives = 59/131 (45%), Gaps = 13/131 (9%)
Query: 1757 NSVIGSVKVLIEGEGLGTVLEDI-AVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVV 1815
N +GS + E GLGT+ + +IG+Q N+ H ++
Sbjct: 195 NRQMGSCYPIQEDHGLGTLQCHVEGDYIGSQNVSFSVFNKGKSMV--------HKKAWLI 246
Query: 1816 VGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEPCQIISI 1875
+ L L + + S+ P +GS+GG T + ITG+ F+ + VTI PC I +
Sbjct: 247 SAKQDLFLYQ---THSEILSVFPETGSLGGRTNITITGD-FFDNSAQVTIAGIPCDIRHV 302
Query: 1876 NPNEVYCRTPA 1886
+P ++ C T A
Sbjct: 303 SPRKIECTTRA 313
Score = 45.4 bits (106), Expect = 0.001
Identities = 80/332 (24%), Positives = 128/332 (38%), Gaps = 84/332 (25%)
Query: 1159 HIWPDSGSIAGGTLLTLSGFGF-------NENSKVLVGNETCNVIEG------------- 1198
HI P+ GS+AGGT +T+ G N S++ + N++
Sbjct: 24 HIEPEEGSLAGGTWITVIFDGLELGVLYPNNGSQLEIHLVNVNMVVPALRSVPCDVFPVF 83
Query: 1199 -DLNRITCRT----PKKTEGTVDISVTTNGFQATA-----RDA--FSYNCLQTPIITDFS 1246
DL +TCRT + EG + G ++ RD+ F ++ QTPI+
Sbjct: 84 LDLPVVTCRTRSVLSEAHEGLYFLEAYFGGQLVSSPNPGPRDSCTFKFSKAQTPIVHQVY 143
Query: 1247 P------KVRTILGEVNL-TIKGYNFGNELTQNMAVYV--GGK---TCQILHWNFTD--- 1291
P K+ + G + ++ ++F E + + G K C +++
Sbjct: 144 PPSGVPGKLIHVYGWIITGRLETFDFDAEYIDSPVILEAQGDKWVTPCSLINRQMGSCYP 203
Query: 1292 ---------IRCLLPKLSPGKHDIYVEVRNWGFASTRDK--LNSSIQYVL------EVTS 1334
++C + G ++ V N G + K L S+ Q + E+ S
Sbjct: 204 IQEDHGLGTLQCHVEGDYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLFLYQTHSEILS 263
Query: 1335 MFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKCILHSTGNIFRI 1394
+FP+ GSL G T ITI G F V + IPC++ S I+C + G R+
Sbjct: 264 VFPETGSLGGRTNITITGDFFDN---SAQVTIAGIPCDIRHVSPRKIECTTRAPGKDVRL 320
Query: 1395 T-----NNG-----KDSVHGL-------GYAW 1409
T N G D+V GL GY W
Sbjct: 321 TTPQPGNRGLLFEVGDAVEGLELTEATPGYRW 352
Score = 45.1 bits (105), Expect = 0.002
Identities = 69/303 (22%), Positives = 115/303 (37%), Gaps = 57/303 (18%)
Query: 28 QIIPKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITCD 87
Q + +V I P GS+ G T L+I G GFS+ + + +GN +CD
Sbjct: 1193 QYLTEVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVL----VGNR----------SCD 1238
Query: 88 VEKDASHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTPT 147
+ S I C T P+ +P T + W +P+
Sbjct: 1239 IVNLTEAS--IWCETLPAPQ-----------IPDAGAPTVPAAVEVWAGNRFFARGPSPS 1285
Query: 148 IRS-----ITPLSGTPGTLITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLI 202
+ + + TP + +QG ++ S+++L G N+ + +G + C++
Sbjct: 1286 LVGKGFTFMYEAAATP-VVTAMQG----EITNSSLSLHVGGSNLSNSVILLGNLNCDVET 1340
Query: 203 PQSDNLYGLKLDHPNGDMGSMVCKTTGTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLNK 262
L +G I H++ + Y QK F +
Sbjct: 1341 QSFQGNVSL----------------SGCSIPLHSLEAGI---YPLQVRQKQMGFANMSVV 1381
Query: 263 IAMFQTYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRV-LVGGEPCDILNVTENSI 321
+ F + IFPSQGS GGT LT+ G + VRV L G C IL++ +++I
Sbjct: 1382 LQQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCVILSLGDHTI 1441
Query: 322 CCK 324
C+
Sbjct: 1442 LCQ 1444
Score = 41.6 bits (96), Expect = 0.017
Identities = 30/115 (26%), Positives = 58/115 (50%), Gaps = 15/115 (13%)
Query: 1117 LKCQILNGSAGHAPVAVSMADVGL------AQNVGGEEFYFVYQ--SQISHIWPDSGSIA 1168
L+C + G V+ S+ + G A + ++ F+YQ S+I ++P++GS+
Sbjct: 213 LQCHVEGDYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLFLYQTHSEILSVFPETGSLG 272
Query: 1169 GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITC--RTPKKTEGTVDISVTT 1221
G T +T++G F+ +++V + C++ +I C R P K D+ +TT
Sbjct: 273 GRTNITITGDFFDNSAQVTIAGIPCDIRHVSPRKIECTTRAPGK-----DVRLTT 322
Score = 39.7 bits (91), Expect = 0.064
Identities = 65/299 (21%), Positives = 115/299 (38%), Gaps = 58/299 (19%)
Query: 29 IIPKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITCDV 88
++P++ I P GS G T LT+RG + + + VD + V L +I C V
Sbjct: 1387 VMPRIMAIFPSQGSACGGTILTVRGL-LLNSRRRSVRVDLSGPFTCVILSLGDHTILCQV 1445
Query: 89 EKDASHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTPTI 148
+ +P S+++ V+V +T + C+G+ CT + +P +
Sbjct: 1446 SLEGD----------PLPGASFSLNVTVLVNGLT--SECQGN-----CTLFIREEASPVM 1488
Query: 149 RSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLIPQSDNL 208
+++ + T G+L T+ + G +A +++ V + +PC + + +
Sbjct: 1489 DALS--TNTSGSLTTVL------IRGQRLATTADEPMVFV----DDQLPCNVTFFNASH- 1535
Query: 209 YGLKLDHPNGDMGSMVCKTTGTFIGHHNVS-FILDNDYGRSFPQKMAYFVSSLNKIAMFQ 267
+VC+T G H +S F N Y S N F
Sbjct: 1536 --------------VVCQTRDLAPGPHYLSVFYTRNGY-----------ACSGNVSRHFY 1570
Query: 268 TYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTP 326
+V FP S+ GG+ LTI G + V + + C +N+ I C P
Sbjct: 1571 IMPQVFHYFPKNFSLHGGSLLTIEGTGL-RGQNTTSVYIDQQTCLTVNIGAELIRCIVP 1628
Score = 36.2 bits (82), Expect = 0.71
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 2093 ITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDA 2148
I +V P+ GS G T +T+ G F + + +TIA CD+ + + I C T A
Sbjct: 261 ILSVFPETGSLGGRTNITITGDFFDNSAQ---VTIAGIPCDIRHVSPRKIECTTRA 313
Score = 35.0 bits (79), Expect = 1.6
Identities = 31/121 (25%), Positives = 56/121 (46%), Gaps = 13/121 (10%)
Query: 1600 IGSYPCVVEESSEDSITCHIDPQNSMDVGIRETVTLTVYNLGTAI----NTLSNEFDRRF 1655
+GS + E+ ++ CH++ D + V+ +V+N G ++ L + F
Sbjct: 198 MGSCYPIQEDHGLGTLQCHVEG----DYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLF 253
Query: 1656 VLLPNIDL--VLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECE 1713
+ + ++ V P GS G T++TI G F S+ +V + PC + V+ IEC
Sbjct: 254 LYQTHSEILSVFPETGSLGGRTNITITGDFFDNSA---QVTIAGIPCDIRHVSPRKIECT 310
Query: 1714 T 1714
T
Sbjct: 311 T 311
>gi|126131104 fibrocystin isoform 2 [Homo sapiens]
Length = 3396
Score = 694 bits (1790), Expect = 0.0
Identities = 606/2223 (27%), Positives = 1007/2223 (45%), Gaps = 233/2223 (10%)
Query: 1571 ITPSTGTVNELITIIGHGFSNLPWANKVTIGSYPCVVE-ESSEDSIT---CHIDPQNSMD 1626
+T G + + G SNL + + +G+ C VE +S + +++ C I P +S++
Sbjct: 1303 VTAMQGEITNSSLSLHVGGSNLS-NSVILLGNLNCDVETQSFQGNVSLSGCSI-PLHSLE 1360
Query: 1627 VGIRETVTLTVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIKGSGFAV 1686
GI L V +S ++F ++P I + P+ GS G T +T++G
Sbjct: 1361 AGI---YPLQVRQKQMGFANMSVVL-QQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNS 1416
Query: 1687 SSAGVKV-LMGHFPCKVLSVNYTAIECETS------PAAQQLVDVDLLIHGVPAQCQGNC 1739
V+V L G F C +LS+ I C+ S P A ++V +L++G+ ++CQGNC
Sbjct: 1417 RRRSVRVDLSGPFTCVILSLGDHTILCQVSLEGDPLPGASFSLNVTVLVNGLTSECQGNC 1476
Query: 1740 TFSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIGNQ-QFRAIEVNENNI 1798
T E +P + + N+ VLI G+ L T ++ VF+ +Q N +++
Sbjct: 1477 TLFIREEASPVMDALSTNTSGSLTTVLIRGQRLATTADEPMVFVDDQLPCNVTFFNASHV 1536
Query: 1799 TALVTPLPVGHHSVSVVVGSKGLAL-GNLT---VSSPPVASLSPTSGSIGGGTTLVITGN 1854
L G H +SV G A GN++ P V P + S+ GG+ L I G
Sbjct: 1537 VCQTRDLAPGPHYLSVFYTRNGYACSGNVSRHFYIMPQVFHYFPKNFSLHGGSLLTIEGT 1596
Query: 1855 GFYPGNTT-VTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFTYALE 1913
G NTT V I + C ++I + C P G G V ++I V+ + Y + Y
Sbjct: 1597 GLRGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGN-GSVALEIEVDGLWYHIGVIGYNKA 1655
Query: 1914 DTPFLRGIIPSRGPPGTEI-EITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDH 1972
TP L I S + +I+G+ I + I C N +V+QC+V
Sbjct: 1656 FTPELISISQSDDILTFAVAQISGA------ANIDIFIGMSPCVGVSGNHTVLQCVVPSL 1709
Query: 1973 AGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIIL 2032
G + V + +G A S +VF + I + + G GG + + V G GF+P N
Sbjct: 1710 PAGEYHVRGYDCIRGWASSALVFTSRVIITAVTENFGCLGG-RLVHVFGAGFSPGNVSAA 1768
Query: 2033 VCGSECAI--DRLRSDYTTL----------LCEIPSNNGTGAEQA------CEVSVVNGK 2074
VCG+ C + + S ++ L LC + + E A C+++V
Sbjct: 1769 VCGAPCRVLANATVSAFSCLVLPLDVSLAFLCGLKREEDS-CEAARHTYVQCDLTVAMAT 1827
Query: 2075 DLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDV 2134
+ P+ Y + V A + G S +E + I + C++
Sbjct: 1828 EQLLESWPYLYICEESSQCLFVPDH---WAESMFPSFSGLFISPKLERDEVLIYNSSCNI 1884
Query: 2135 EYSNKTHIICMTDAHTLSGWAPVCVHIRGV----GMAKLDNADFLYVDAWSSNFSWGGKS 2190
+ + C T P+ V I + G N + WS SW +
Sbjct: 1885 TMETEAEMECETPNQ------PITVKITEIRKRWGQNTQGNFSLQFCRRWSRTHSWFPER 1938
Query: 2191 PPEEGSLVVITKGQTILLDQSTPILKMLLIQGGTLIF-DEADIELQAENILITDGGVLQI 2249
P++G V + GQ +LLD +T IL +L I+GG LIF IEL+A IL++DGG L+I
Sbjct: 1939 LPQDGDNVTVENGQLLLLDTNTSILNLLHIKGGKLIFMAPGPIELRAHAILVSDGGELRI 1998
Query: 2250 GTETSPFQHKAVITLHGHLRSPELPVYGAKTLAVREGILDLHGVPVPVTWTRLAHTAKAG 2309
G+E PFQ +A ITL+G S YG K LAVR G L LHG V T L TA A
Sbjct: 1999 GSEDKPFQGRAQITLYGSSYSTPFFPYGVKFLAVRNGTLSLHGSLPEVIVTCLRATAHAL 2058
Query: 2310 ERILILQEAVTWKPGDNIVIAS-TGHRHSQGENEKMTIASVSADGINITLSNPLNYTHLG 2368
+ +L L++AV W PGD +VI S TG + ++ E +T+ +V ++ L +PL Y+H
Sbjct: 2059 DTVLALEDAVDWNPGDEVVIISGTGVKGAKPMEEIVTVETV--QDTDLYLKSPLRYSH-N 2115
Query: 2369 ITVTLPDGTLFEARAEVGILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKF 2428
T G +A V +L+R+I I+G+ E + +C + + E Q CL
Sbjct: 2116 FTENWVAGEHHILKATVALLSRSITIQGNLTNEREKLLVSCQEA-NAPEGNLQHCLYSMS 2174
Query: 2429 GEEIGSDQFGGCVMFHAPVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKS 2488
+ +GS G V+ + + V +++ V+ GQAF ++ L+G ++ +S
Sbjct: 2175 EKMLGSRDMGARVIVQSFPEEPSQV--QLKGVQFQVLGQAFH--KHLSSLTLVGAMR-ES 2229
Query: 2489 YVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFI------------------ED 2530
+++GC + +++R +++ T L V+ N+ Y+I G A + +D
Sbjct: 2230 FIQGCTVRNSFSRGLSMCGTLGLKVDSNVFYNILGHALLVGTCTEMRYISWEAIHGRKDD 2289
Query: 2531 GIEHGNILQYNLAVFVQQSTSLLNDD-VTPAAFWVTNPNNTIRHNAVAGGTHFGFWYRMN 2589
HGNI++ N+ + V + L N + +TP+ ++ +P N I N V G + F++ M
Sbjct: 2290 WSGHGNIIRNNVIIQVSGAEGLSNPEMLTPSGIYICSPTNVIEGNRVCGAGYGYFFHLMT 2349
Query: 2590 NHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMWIFEEYFPMQTGSCTSTVPAPAIFN 2649
N + PL F N HS +G++++ ++ P V +F
Sbjct: 2350 NQ-----------TSQAPLLSFTQNIAHSCTRYGLFVYPKFQPP-----WDNVTGTTLFQ 2393
Query: 2650 SLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIETKRILAPYVGGWGETNGAVIKNAKI 2709
S T W GA+ L+ NF + + + GI+ + N +V ++ +
Sbjct: 2394 SFTVWESAGGAQIFRSSNLRLKNFKVYSCRDFGIDVLE---------SDANTSV-TDSLL 2443
Query: 2710 VGHLDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMNFDRPNCVALGVTSISGVCNDRCGG 2769
+GH G + C + G+ P L VS+ F+NFD NCVA+ S C+ GG
Sbjct: 2444 LGHFAHKG---SLCMSSGIKTPKRWELMVSNTTFVNFDLINCVAIRTCS---DCSQGQGG 2497
Query: 2770 WSAKFVDVQYSHTPNKAGFRWEHEMVMIDVDGSLTGHKGHTVIPHSSLLDPSHCTQEAEW 2829
++ K ++++++ N F + H ++ D+DGSL+G ++ L S C + +
Sbjct: 2498 FTVKTSQLKFTNSSNLVAFPFPHAAILEDLDGSLSGKNRSHILASMETLSAS-CLVNSSF 2556
Query: 2830 SIGFPGSVCDASVSFHRLAF---NQPSPVSLLEKDVVLSDSFG-TSIIPFQKKRLTHMSG 2885
GS C V FHR++ N P + D+ ++DS T+ + + + L++ G
Sbjct: 2557 GRVVHGSACGGGVLFHRMSIGLANTPE----VSYDLTMTDSRNKTTTVNYVRDTLSNPRG 2612
Query: 2886 WMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVIISH-NFTQNPDMFNIIDMRN 2944
WMAL+ + + + + ++ Y++TF F +Y+++ H + PD+ R
Sbjct: 2613 WMALLLDQETYSLQSENLWINRSLQYSATFDNFAPGNYLLLVHTDLPPYPDILLRCGSRV 2672
Query: 2945 GSSNPLNWNTSKNG--DWHLEANTSTLYYLVSGRNDLHQSQLISGNLDPDVKDVVINFQA 3002
G S P + +N DW + L YLVSG + + + P +
Sbjct: 2673 GLSFPFLPSPGQNQGCDWFFNSQLRQLTYLVSGEGQVQVILRVKEGMPPTIS-------- 2724
Query: 3003 YCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSFWQSSREN----NYTVPHPGANVIIP 3058
P + WS WQ E N T+P PG +V+I
Sbjct: 2725 ------------------ASTSAPESALKWSLPETWQGVEEGWGGYNNTIPGPGDDVLIL 2766
Query: 3059 EGTWIVADIDMPSMERLIIWGVLELE-DKYNVGAAESSYREVVLNATYISLQGGRLIGGW 3117
++ D D+P + L + G L+ D+ N VL+ + + GG L G
Sbjct: 2767 PNRTVLVDTDLPFFKGLYVMGTLDFPVDRSN-----------VLSVACMVIAGGELKVGT 2815
Query: 3118 EDNPFKGDLK--IVLRGNHTTQDWALPEGPNQGAKVLGVFGELDLHGIPHSIYKTKLSET 3175
+NP + + K I+LR + + G + +GV+G++ L+ T L
Sbjct: 2816 LENPLEKEQKLLILLRASEGVFCDRM-NGIHIDPGTIGVYGKVHLYSAYPKNSWTHLGAD 2874
Query: 3176 AFAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKILILNDSLSYTHF 3235
+G++ + + DAVDW+ ++IV++++SY+ H+ E ++ ++ H + + + L + H
Sbjct: 2875 IASGNERIIVEDAVDWRPHDKIVLSSSSYEPHEAEVLTVKEVKGHH--VRIYERLKHRHI 2932
Query: 3236 AEKYHVPGTGESYTLAADVGILSRNIKIVGEDYPGWSEDSFGARVLVGSFTENMM-TFKG 3294
HV G LAA+VG+L+RNI+I + S R+ VGSF ++ F G
Sbjct: 2933 G-SVHVTEDGRHIRLAAEVGLLTRNIQI-------QPDVSCRGRLFVGSFRKSSREEFSG 2984
Query: 3295 NARISNVEFYHSGQEGFRDSTDPRY-AVTFLNLGQIQEHGSSYIRGCAFHHGFSPAIGVF 3353
++ NVE + G P Y +V F N+ S+I H I
Sbjct: 2985 VLQLLNVEIQNFG--------SPLYSSVEFSNVS-----AGSWIISSTLHQSCGGGIHAA 3031
Query: 3354 GTDGLDIDDNIIHFTVGEGIRIWGNANRVRGNLIALSVWPGTYQNRKDLSSTLWHAAIEI 3413
+ G+ ++DNI+ T G GI + G A V NL+ L P ST+W A I++
Sbjct: 3032 ASHGVLLNDNIVFGTAGHGIDLEGQAYTVTNNLVVLMTQPAW--------STIWVAGIKV 3083
Query: 3414 NRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLYGIYM-NQDGLPG 3472
N+ + L NVVAG R G+ I G C + W DN AH L+G+++ + GL
Sbjct: 3084 NQVKDINLHGNVVAGSERLGFHIRGHKCS---SCELLWSDNVAHSSLHGLHLYKESGLDN 3140
Query: 3473 CSLIQGFTIWTCWDYGIYFQTTESVHIYNVTLVDNGMAIFPMIYMPAAISHKISSKNVQI 3532
C+ I GF + +DYG SV I N+TLVDN + + ++Y+ +A + + + +
Sbjct: 3141 CTRISGFLAFKNFDYGAMLHVENSVEIENITLVDNTIGLLAVVYVFSAPQNSVKKVQIVL 3200
Query: 3533 KSSLIVGSSPGFNC-SDVLTNDDPNIELTAAHRSPRSPSGGRSGICWPTFASAHNMAPRK 3591
++S+IV +S F+C D + N LT+ R+P +P GGR GI WP F S N P++
Sbjct: 3201 RNSVIVATSSSFDCIQDKVKPHSAN--LTSTDRAPSNPRGGRIGILWPVFTSEPNQWPQE 3258
Query: 3592 PHAGIMSYNAISGLLDISGSTFVGFKNVC-SGETNVIFITNPLNEDLQHPIHVKNIKLVD 3650
P + + ++ISG++ + TF F C S + +V + N N + HPI + +++
Sbjct: 3259 PWHKVRNDHSISGIMKLQDVTFSSFVKSCYSDDLDVCILPNAENSGIMHPITAERTRMLK 3318
Query: 3651 TTEQSKIFI----HRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLG--NAGSVIPQAE 3704
+++K + R D+ KV C ++ C + RK +D+DG LG SV P+ E
Sbjct: 3319 IKDKNKFYFPSLQPRKDLGKV---VCPELDCASPRKYLFKDLDGRALGLPPPVSVFPKTE 3375
Query: 3705 YEW 3707
EW
Sbjct: 3376 AEW 3378
Score = 257 bits (656), Expect = 2e-67
Identities = 319/1323 (24%), Positives = 536/1323 (40%), Gaps = 183/1323 (13%)
Query: 637 FTLNWDGIASKPLTLWSSEAEFQGAVEEMVSTKCP--PQIAN------FEEGFVVKYFRD 688
F L WD ++S+P+ ++ Q +EE+++ KC P +N FE G V
Sbjct: 514 FFLTWDNVSSQPIPANATAHLIQTTIEELLAVKCKLEPLWSNILLRLGFERGPEVSN--- 570
Query: 689 YETDFNLEHINRGQKTAETDAYCGRYSLKNPA--VLFDSADVKPNRRPYGDILLFPYNQL 746
+ G T+ T+ +CGR+SL+ P VL A K R L Y L
Sbjct: 571 ----------SDGDLTSGTEPFCGRFSLRQPRHLVLTPPAAQKGYR-------LDQYTHL 613
Query: 747 CLAYKGFLANYIGLKFQYQDN-SKITRSTDTQFTYNFAYGNNWTYTCIDLLDL------- 798
CLAYKG + + + + + ++T ++ +W + C DL +
Sbjct: 614 CLAYKGHMNKILKMIVSFTIGFQNMVKNTTCDWSLTRTSPESWQFDCTDLWETCVRCFGD 673
Query: 799 VRTKYTGTNVSLQRISLHK-ASESQSFYVDVVYIGHTS-TISTLDEMPKRRLPALANKGI 856
++ + V + +I+L A E+ FYVD + I T+ T+S D R G
Sbjct: 674 LQPPPANSPVLVHQINLLPLAQETGLFYVDEIIIADTNVTVSQADSGTARP------GGN 727
Query: 857 FLEHFQVNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNW 916
+E V P + YSVT C +P++ + T TE
Sbjct: 728 LVESVSV----VGSPPV---YSVTSWLAGCGTELPLITAR--SVPTEGTEEG-------- 770
Query: 917 PGESKIHIQRIQAASPPLSGSFDIQAYGHILKGLPAAVSAADLQFALQSLE--------G 968
G + QR Q SPPL G F IQ ++ +P +SA L LQ+
Sbjct: 771 SGLVLVTTQRRQRTSPPLGGHFRIQLPNTVISDVPVQISAHHLHQLLQNNADDFTSRYLN 830
Query: 969 MGRISVTRE-GTCAGYAWNIKWRSTCGK-QNLLQINDSNIIGEKANMTVTRIKEGGLFRQ 1026
+V + TC + W + W + G N ++++D N+ G + +GG+F
Sbjct: 831 ASDFTVKEDLYTCYEHVWTLSWSTQIGDLPNFIRVSDENLTGVNPAAATRVVYDGGVFLG 890
Query: 1027 HVLGDLLRTPSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYEEGTILT 1086
+ GD+L T +Q QV V VN +PA C G C F + TP V ++ S + ++
Sbjct: 891 PIFGDMLATANQHTQVVVRVNDVPAHCPGSCSFQYLQGSTPCVHSVWYSIDG-DINLMIY 949
Query: 1087 IVGSGFS-PSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQNVG 1145
I G+GFS S + V+V C ++ ++ + CQ G + + + GLA +
Sbjct: 950 ITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGLAISAT 1009
Query: 1146 GEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNETC--NVIEGDLNRI 1203
GE+ + + ++ + P + GG T+ G S +L G+ +C NV + +RI
Sbjct: 1010 GEDLFLNVKPRLDMVEPSRAADIGGLWATIRGSSLEGVSLILFGSYSCAINVATSNSSRI 1069
Query: 1204 TCRTPK--KTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIK 1261
C+ P K V+++V + A AF+Y P+I S + I G L I
Sbjct: 1070 QCKVPPRGKDGRIVNVTVIRGDYSAVLPRAFTYVSSLNPVIVTLSRNISNIAGGETLVIG 1129
Query: 1262 GYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFASTRDK 1321
N ++ V+V + + + LP L G H I V + G +
Sbjct: 1130 VARLMNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSIN--GVSIHSQG 1187
Query: 1322 LNSSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVI 1381
++ IQY+ EV S+ P GSL GGT ++I G GFS PA VL+G+ C++ + +E I
Sbjct: 1188 VDLHIQYLTEVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASI 1247
Query: 1382 KCILHSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLRGIGYRIFS 1441
C T +I + G +V W+ G R F+
Sbjct: 1248 WC---ETLPAPQIPDAGAPTVPAAVEVWA-------------------------GNRFFA 1279
Query: 1442 VSSPGSVIYDGKGFTSGRQKSTS---GSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVINV 1498
S++ GKGFT + + + + + T+ + + G + ++S+ L G +N
Sbjct: 1280 RGPSPSLV--GKGFTFMYEAAATPVVTAMQGEITNSSLSLHVGG-SNLSNSVILLGNLNC 1336
Query: 1499 LPAETRHIPLHLFVGRSEATYAYGGPENLHLGSSVAGCLATEPLCSLN----NTRVKNSK 1554
T ++ G S++GC + PL SL +V+ +
Sbjct: 1337 ----------------DVETQSFQG------NVSLSGC--SIPLHSLEAGIYPLQVRQKQ 1372
Query: 1555 RLLFEVSSCFS-----PSISNITPSTGTV--NELITIIGHGFSNLPWANKVTI-GSYPCV 1606
+S P I I PS G+ ++T+ G ++ + +V + G + CV
Sbjct: 1373 MGFANMSVVLQQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCV 1432
Query: 1607 VEESSEDSITCHIDPQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRRFVLL------PN 1660
+ + +I C + + G ++ +TV +N L++E L P
Sbjct: 1433 ILSLGDHTILCQVSLEGDPLPGASFSLNVTV-----LVNGLTSECQGNCTLFIREEASPV 1487
Query: 1661 IDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLM-GHFPCKVLSVNYTAIECETSPAAQ 1719
+D + N + +T+V I+G A ++ V + PC V N + + C+T A
Sbjct: 1488 MDALSTNTSGS--LTTVLIRGQRLATTADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAP 1545
Query: 1720 QLVDVDLLIHGVPAQCQGNCTFSYLESITPYITGVFPN--SVIGSVKVLIEGEGLGTVLE 1777
+ + C GN + + I P + FP S+ G + IEG GL
Sbjct: 1546 GPHYLSVFYTRNGYACSGNVSRHFY--IMPQVFHYFPKNFSLHGGSLLTIEGTGL-RGQN 1602
Query: 1778 DIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGL-----ALGNLTVSSPP 1832
+V+I Q + + I +V P G+ SV++ + GL +G +P
Sbjct: 1603 TTSVYIDQQTCLTVNIGAELIRCIV---PTGNGSVALEIEVDGLWYHIGVIGYNKAFTPE 1659
Query: 1833 VASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEPCQIISINPNEVYCRTPAGTTGMV 1892
+ S+S + + T V +G N + IG PC +S N + C P+ G
Sbjct: 1660 LISISQSDDIL---TFAVAQISG--AANIDIFIGMSPCVGVSGNHTVLQCVVPSLPAGEY 1714
Query: 1893 DVK 1895
V+
Sbjct: 1715 HVR 1717
Score = 188 bits (477), Expect = 1e-46
Identities = 156/540 (28%), Positives = 244/540 (45%), Gaps = 64/540 (11%)
Query: 5 WLLGIWGLCGLLLCAADPSTDGSQIIPKVTEIIPKYGSINGATRLTIRGEGFSQANQFNY 64
WL+ + + LLL S I P+ GS+ G T +T+ +G +
Sbjct: 4 WLISLMSIEVLLLAVRHLSL----------HIEPEEGSLAGGTWITVIFDGLELGVLYPN 53
Query: 65 GVDNAE--LGNSVQLISSFQSITCDVEKDASHSTQITCYTRAMPEDS----YTVRVSVDG 118
E L N ++ + +S+ CDV +TC TR++ ++ Y + G
Sbjct: 54 NGSQLEIHLVNVNMVVPALRSVPCDVFPVFLDLPVVTCRTRSVLSEAHEGLYFLEAYFGG 113
Query: 119 VPVTENNTCKGHINSWECTFNAKSFRTPTIRSITPLSGTPGTLITIQGRIFT-------- 170
V+ N G +S CTF +TP + + P SG PG LI + G I T
Sbjct: 114 QLVSSPNP--GPRDS--CTFKFSKAQTPIVHQVYPPSGVPGKLIHVYGWIITGRLETFDF 169
Query: 171 --DVYGSNIALSSNGKNVRILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTT 228
+ S + L + G PC L+ Q + Y ++ DH +G++ C
Sbjct: 170 DAEYIDSPVILEAQGDK--------WVTPCSLINRQMGSCYPIQEDH---GLGTLQCHVE 218
Query: 229 GTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLNKIAMFQTYAEVTMIFPSQGSIRGGTTL 288
G +IG NVSF + N G+S K A+ +S+ + ++QT++E+ +FP GS+ G T +
Sbjct: 219 GDYIGSQNVSFSVFNK-GKSMVHKKAWLISAKQDLFLYQTHSEILSVFPETGSLGGRTNI 277
Query: 289 TISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKT--PPKPHILKTVYPGGRGLKLEV 346
TI+G FFD + +V + G PCDI +V+ I C T P K L T PG RGL EV
Sbjct: 278 TITGDFFDNS---AQVTIAGIPCDIRHVSPRKIECTTRAPGKDVRLTTPQPGNRGLLFEV 334
Query: 347 WNNSRPIRLEEILEYNEKTPGYMGASWVDSASYI--WLMEQDTFVARFSGFLVAPDSDVY 404
+ E LE E TPGY +++S W E F AR SGF VAP+++ Y
Sbjct: 335 GD------AVEGLELTEATPGYRWQIVPNASSPFGFWSQEGQPFRARLSGFFVAPETNNY 388
Query: 405 RFYIKGDDRYAIYFSQTGLPEDKVRIAYHSANANSYFSSPTQRSDD---------IHLQK 455
F+I+ D + +++FS + P KV++A S +F S Q D+ + L
Sbjct: 389 TFWIQADSQASLHFSWSEEPRTKVKVASISVGTADWFDSWEQNRDEGTWQQKTPKLELLG 448
Query: 456 GKEYYIEILLQEYRLSAFVDVGLYQYRNVYTEQQTGDAVNEEQVIKSQSTILQEVQVITL 515
G YY+E S + +G+ + + E+ I+ ++ L EVQV+ +
Sbjct: 449 GAMYYLEAEHHGIAPSRGMRIGVQIHNTWLNPDVVTTYLREKHQIRVRAQRLPEVQVLNV 508
Score = 123 bits (308), Expect = 4e-27
Identities = 156/622 (25%), Positives = 262/622 (42%), Gaps = 74/622 (11%)
Query: 1576 GTVNELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNSMDVGIRETVTL 1635
G +N +I I G GFS +VT+ C V S++ ++ C D + VG+ + +
Sbjct: 942 GDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTD---LLPVGMHR-ILM 997
Query: 1636 TVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVK-VL 1694
V G AI+ D + P +D+V P+ + G TI+GS S GV +L
Sbjct: 998 LVRPSGLAISATGE--DLFLNVKPRLDMVEPSRAADIGGLWATIRGS----SLEGVSLIL 1051
Query: 1695 MGHFPC--KVLSVNYTAIECETSPAAQ--QLVDVDLLIHGVPAQCQGNCTFSYLESITPY 1750
G + C V + N + I+C+ P + ++V+V ++ A F+Y+ S+ P
Sbjct: 1052 FGSYSCAINVATSNSSRIQCKVPPRGKDGRIVNVTVIRGDYSAVLPR--AFTYVSSLNPV 1109
Query: 1751 ITGVFPN-SVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNEN--NITALVTPLPV 1807
I + N S I + L+ G D+ V + Q A ++ + + PLP
Sbjct: 1110 IVTLSRNISNIAGGETLVIGVARLMNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPA 1169
Query: 1808 GHHSVSVVVG-----SKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFY--PGN 1860
G H +SV + S+G+ L ++ V S+ P GS+ GGT L I+G GF P
Sbjct: 1170 GLHRISVSINGVSIHSQGVDLHIQYLTE--VFSIEPCCGSLLGGTILSISGIGFSRDPAL 1227
Query: 1861 TTVTIGDEPCQIISINPNEVYCRT--------------PAGTTGMVDVKIFVN----TIA 1902
V +G+ C I+++ ++C T PA + F ++
Sbjct: 1228 VWVLVGNRSCDIVNLTEASIWCETLPAPQIPDAGAPTVPAAVEVWAGNRFFARGPSPSLV 1287
Query: 1903 YPPLLFTYALEDTPFLRGIIPSRGPPGTEIEITGSNFGFEILEISVMINNIQCNVT---- 1958
F Y TP + + + + GSN + +++ N+ C+V
Sbjct: 1288 GKGFTFMYEAAATPVVTAMQGEITNSSLSLHVGGSNLSNSV----ILLGNLNCDVETQSF 1343
Query: 1959 MANDSVVQCIVGDHA--GGTFPVMMHHKTKGSAMSTVV---FEYPLNIQNINPSQGSFGG 2013
N S+ C + H+ G +P+ + K G A +VV F I I PSQGS G
Sbjct: 1344 QGNVSLSGCSIPLHSLEAGIYPLQVRQKQMGFANMSVVLQQFAVMPRIMAIFPSQGSACG 1403
Query: 2014 GQTMTVTGTGFNPQNSIILVCGS---ECAIDRLRSDYTTLLCEIPSNNG--TGAEQACEV 2068
G +TV G N + + V S C I L T+LC++ GA + V
Sbjct: 1404 GTILTVRGLLLNSRRRSVRVDLSGPFTCVILSLGDH--TILCQVSLEGDPLPGASFSLNV 1461
Query: 2069 SV-VNG-KDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGG-TRLTVVGSGFSENMEDVHI 2125
+V VNG Q +P++ A+S +T+G T + + G + ++ +
Sbjct: 1462 TVLVNGLTSECQGNCTLFIREEASPVMDALST---NTSGSLTTVLIRGQRLATTADEPMV 1518
Query: 2126 TI-AEAKCDVEYSNKTHIICMT 2146
+ + C+V + N +H++C T
Sbjct: 1519 FVDDQLPCNVTFFNASHVVCQT 1540
Score = 89.4 bits (220), Expect = 7e-17
Identities = 123/544 (22%), Positives = 214/544 (39%), Gaps = 71/544 (13%)
Query: 1577 TVNELITIIGHGFSNLPWANKVTIGSYPCV------VEESSEDSIT-CHIDPQNSMDVGI 1629
++N +I + SN+ + IG + VE +D++ H ++V +
Sbjct: 1105 SLNPVIVTLSRNISNIAGGETLVIGVARLMNYTDLDVEVHVQDALAPVHTQSAWGLEVAL 1164
Query: 1630 RETVTLTVYNLGTAINTLS---NEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIKGSGFAV 1686
+ ++ + +IN +S D L + + P GS G T ++I G GF+
Sbjct: 1165 -PPLPAGLHRISVSINGVSIHSQGVDLHIQYLTEVFSIEPCCGSLLGGTILSISGIGFSR 1223
Query: 1687 SSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVPAQCQ---GN----- 1738
A V VL+G+ C ++++ +I CET PA Q D VPA + GN
Sbjct: 1224 DPALVWVLVGNRSCDIVNLTEASIWCETLPAPQ---IPDAGAPTVPAAVEVWAGNRFFAR 1280
Query: 1739 ----------CTFSYLESITPYITGVFPNSVIGSVKVLIEGEG-------LGTVLEDIAV 1781
TF Y + TP +T + S+ + + G LG + D+
Sbjct: 1281 GPSPSLVGKGFTFMYEAAATPVVTAMQGEITNSSLSLHVGGSNLSNSVILLGNLNCDVET 1340
Query: 1782 --FIGNQQFRAIEVNENNITALVTPLPV-----GHHSVSVVVGSKGLALGNLTVSSPPVA 1834
F GN + +++ A + PL V G ++SVV+ + P +
Sbjct: 1341 QSFQGNVSLSGCSIPLHSLEAGIYPLQVRQKQMGFANMSVVLQQFAV--------MPRIM 1392
Query: 1835 SLSPTSGSIGGGTTLVITGNGFYPGNTTVTI---GDEPCQIISINPNEVYCRTP------ 1885
++ P+ GS GGT L + G +V + G C I+S+ + + C+
Sbjct: 1393 AIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCVILSLGDHTILCQVSLEGDPL 1452
Query: 1886 AGTTGMVDVKIFVNTI---AYPPLLFTYALEDTPFLRGIIPSRGPPGTEIEITGSNFGFE 1942
G + ++V + VN + E +P + + + T + I G
Sbjct: 1453 PGASFSLNVTVLVNGLTSECQGNCTLFIREEASPVMDALSTNTSGSLTTVLIRGQRLATT 1512
Query: 1943 ILEISVMINN-IQCNVTMANDSVVQCIVGDHAGGTFPVMMHHKTKGSAMSTVV---FEYP 1998
E V +++ + CNVT N S V C D A G + + + G A S V F
Sbjct: 1513 ADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAPGPHYLSVFYTRNGYACSGNVSRHFYIM 1572
Query: 1999 LNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNN 2058
+ + P S GG +T+ GTG QN+ + + + + + C +P+ N
Sbjct: 1573 PQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYIDQQTCL-TVNIGAELIRCIVPTGN 1631
Query: 2059 GTGA 2062
G+ A
Sbjct: 1632 GSVA 1635
Score = 88.2 bits (217), Expect = 2e-16
Identities = 114/488 (23%), Positives = 201/488 (41%), Gaps = 45/488 (9%)
Query: 1718 AQQLVDVDLLIHGVPAQCQGNCTFSYLESITPYITGVFPNSVIGSVKVL--IEGEGLGTV 1775
A Q V + ++ VPA C G+C+F YL+ TP + V+ S+ G + ++ I G G
Sbjct: 900 ANQHTQVVVRVNDVPAHCPGSCSFQYLQGSTPCVHSVW-YSIDGDINLMIYITGTGFSGD 958
Query: 1776 LEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALG----NLTVS-S 1830
+ + V + + I N+ N+ LPVG H + ++V GLA+ +L ++
Sbjct: 959 SQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGLAISATGEDLFLNVK 1018
Query: 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEPC--QIISINPNEVYCRT-PAG 1887
P + + P+ + GG I G+ G + + G C + + N + + C+ P G
Sbjct: 1019 PRLDMVEPSRAADIGGLWATIRGSSL-EGVSLILFGSYSCAINVATSNSSRIQCKVPPRG 1077
Query: 1888 TTG-MVDVKIFVNTI-AYPPLLFTYALEDTPFL----RGIIPSRGPPGTEIEITGSNFGF 1941
G +V+V + A P FTY P + R I G I + +
Sbjct: 1078 KDGRIVNVTVIRGDYSAVLPRAFTYVSSLNPVIVTLSRNISNIAGGETLVIGV-ARLMNY 1136
Query: 1942 EILEISVMINNIQCNVTMANDSVVQCIVGDHAGG--TFPVMMHHKTKGSAMSTVVFEYPL 1999
L++ V + + V + ++ + G V ++ + S + +Y
Sbjct: 1137 TDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQGVDLHIQYLT 1196
Query: 2000 NIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCE------ 2053
+ +I P GS GG ++++G GF+ +++ V + D + ++ CE
Sbjct: 1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQ 1256
Query: 2054 IPSNNGTGAEQACEVSVVN---GKDLSQSMT----PFTYAVSLTPLITAVSPKRGSTAGG 2106
IP A EV N + S S+ F Y + TP++TA+ + T
Sbjct: 1257 IPDAGAPTVPAAVEVWAGNRFFARGPSPSLVGKGFTFMYEAAATPVVTAMQGE--ITNSS 1314
Query: 2107 TRLTVVGSGFSENMEDVHITIAEAKCDVE----YSNKTHIICMTDAHTL-SGWAPVCVHI 2161
L V GS S ++ I + CDVE N + C H+L +G P+ V
Sbjct: 1315 LSLHVGGSNLSNSV----ILLGNLNCDVETQSFQGNVSLSGCSIPLHSLEAGIYPLQVRQ 1370
Query: 2162 RGVGMAKL 2169
+ +G A +
Sbjct: 1371 KQMGFANM 1378
Score = 77.0 bits (188), Expect = 4e-13
Identities = 82/356 (23%), Positives = 149/356 (41%), Gaps = 32/356 (8%)
Query: 1030 GDLLRTPSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYEEGTILTIVG 1089
GD L S V V VNG+ ++C G+C +P++ A+S + G++ T++
Sbjct: 1449 GDPLPGASFSLNVTVLVNGLTSECQGNCTLFIREEASPVMDALSTN----TSGSLTTVLI 1504
Query: 1090 SG----FSPSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQNVG 1145
G + + + C++ + + CQ + + G ++V G A + G
Sbjct: 1505 RGQRLATTADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAPGPHYLSVFYTRNGYACS-G 1563
Query: 1146 GEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGF--NENSKVLVGNETCNVIEGDLNRI 1203
+F Q+ H +P + S+ GG+LLT+ G G + V + +TC + I
Sbjct: 1564 NVSRHFYIMPQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYIDQQTCLTVNIGAELI 1623
Query: 1204 TCRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGY 1263
C P G+V + + +G YN TP + S + IL I G
Sbjct: 1624 RCIVP-TGNGSVALEIEVDGLWYHI-GVIGYNKAFTPELISIS-QSDDILTFAVAQISG- 1679
Query: 1264 NFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDI--YVEVRNWGFASTRDK 1321
N+ +++G C + N T ++C++P L G++ + Y +R W ++
Sbjct: 1680 ------AANIDIFIGMSPCVGVSGNHTVLQCVVPSLPAGEYHVRGYDCIRGWASSAL--- 1730
Query: 1322 LNSSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSS 1377
+ +S + VT F GG + + G GFS P + + PC V +++
Sbjct: 1731 VFTSRVIITAVTENF----GCLGGRLVHVFGAGFS--PGNVSAAVCGAPCRVLANA 1780
Score = 59.3 bits (142), Expect = 8e-08
Identities = 38/85 (44%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 267 QTYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTP 326
Q EV I P GS+ GGT L+ISG F + V VLVG CDI+N+TE SI C+T
Sbjct: 1193 QYLTEVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETL 1252
Query: 327 PKPHILKTVYPGGRGLKLEVWNNSR 351
P P I P +EVW +R
Sbjct: 1253 PAPQIPDAGAPTVPA-AVEVWAGNR 1276
Score = 47.4 bits (111), Expect = 3e-04
Identities = 110/460 (23%), Positives = 166/460 (36%), Gaps = 98/460 (21%)
Query: 1842 SIGGGTTLVI--TGNGFYPGNT--TVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIF 1897
SI G L+I TG GF + VT+ C++I N V C+T GM + +
Sbjct: 939 SIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILML 998
Query: 1898 VNT--IAYPPLLFTYALEDTPFLRGIIPSRGPP--GTEIEITGSNFGFEILEISVMINNI 1953
V +A L P L + PSR G I GS+ L ++ +
Sbjct: 999 VRPSGLAISATGEDLFLNVKPRLDMVEPSRAADIGGLWATIRGSSLEGVSL---ILFGSY 1055
Query: 1954 QC--NVTMANDSVVQCIVGDHA------------GGTFPVMMHHKTKGSAMSTVVFEYPL 1999
C NV +N S +QC V G V+ T S+++ V+
Sbjct: 1056 SCAINVATSNSSRIQCKVPPRGKDGRIVNVTVIRGDYSAVLPRAFTYVSSLNPVIVTLSR 1115
Query: 2000 NIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTL--------- 2050
NI NI GG+T+ + + RL + YT L
Sbjct: 1116 NISNI-------AGGETLVI-------------------GVARLMN-YTDLDVEVHVQDA 1148
Query: 2051 LCEIPSNNGTGAEQAC--------EVSV-VNGKDLSQSMTPFTYAVSLTPLITAVSPKRG 2101
L + + + G E A +SV +NG + + + ++ P G
Sbjct: 1149 LAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQGVDLH--IQYLTEVFSIEPCCG 1206
Query: 2102 STAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVHI 2161
S GGT L++ G GFS + V + + CD+ + I C T AP I
Sbjct: 1207 SLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLP------AP---QI 1257
Query: 2162 RGVGMAKLDNADFLYVDAWSSN-FSWGGKSPPEEGSLVVITKGQTILLD-QSTPILKMLL 2219
G + A V+ W+ N F G SP ++ KG T + + +TP++ +
Sbjct: 1258 PDAGAPTVPAA----VEVWAGNRFFARGPSPS------LVGKGFTFMYEAAATPVVTAMQ 1307
Query: 2220 --IQGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQ 2257
I +L L IL+ G L ET FQ
Sbjct: 1308 GEITNSSLSLHVGGSNLSNSVILL---GNLNCDVETQSFQ 1344
Score = 46.6 bits (109), Expect = 5e-04
Identities = 36/131 (27%), Positives = 59/131 (45%), Gaps = 13/131 (9%)
Query: 1757 NSVIGSVKVLIEGEGLGTVLEDI-AVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVV 1815
N +GS + E GLGT+ + +IG+Q N+ H ++
Sbjct: 195 NRQMGSCYPIQEDHGLGTLQCHVEGDYIGSQNVSFSVFNKGKSMV--------HKKAWLI 246
Query: 1816 VGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEPCQIISI 1875
+ L L + + S+ P +GS+GG T + ITG+ F+ + VTI PC I +
Sbjct: 247 SAKQDLFLYQ---THSEILSVFPETGSLGGRTNITITGD-FFDNSAQVTIAGIPCDIRHV 302
Query: 1876 NPNEVYCRTPA 1886
+P ++ C T A
Sbjct: 303 SPRKIECTTRA 313
Score = 45.4 bits (106), Expect = 0.001
Identities = 80/332 (24%), Positives = 128/332 (38%), Gaps = 84/332 (25%)
Query: 1159 HIWPDSGSIAGGTLLTLSGFGF-------NENSKVLVGNETCNVIEG------------- 1198
HI P+ GS+AGGT +T+ G N S++ + N++
Sbjct: 24 HIEPEEGSLAGGTWITVIFDGLELGVLYPNNGSQLEIHLVNVNMVVPALRSVPCDVFPVF 83
Query: 1199 -DLNRITCRT----PKKTEGTVDISVTTNGFQATA-----RDA--FSYNCLQTPIITDFS 1246
DL +TCRT + EG + G ++ RD+ F ++ QTPI+
Sbjct: 84 LDLPVVTCRTRSVLSEAHEGLYFLEAYFGGQLVSSPNPGPRDSCTFKFSKAQTPIVHQVY 143
Query: 1247 P------KVRTILGEVNL-TIKGYNFGNELTQNMAVYV--GGK---TCQILHWNFTD--- 1291
P K+ + G + ++ ++F E + + G K C +++
Sbjct: 144 PPSGVPGKLIHVYGWIITGRLETFDFDAEYIDSPVILEAQGDKWVTPCSLINRQMGSCYP 203
Query: 1292 ---------IRCLLPKLSPGKHDIYVEVRNWGFASTRDK--LNSSIQYVL------EVTS 1334
++C + G ++ V N G + K L S+ Q + E+ S
Sbjct: 204 IQEDHGLGTLQCHVEGDYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLFLYQTHSEILS 263
Query: 1335 MFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKCILHSTGNIFRI 1394
+FP+ GSL G T ITI G F V + IPC++ S I+C + G R+
Sbjct: 264 VFPETGSLGGRTNITITGDFFDN---SAQVTIAGIPCDIRHVSPRKIECTTRAPGKDVRL 320
Query: 1395 T-----NNG-----KDSVHGL-------GYAW 1409
T N G D+V GL GY W
Sbjct: 321 TTPQPGNRGLLFEVGDAVEGLELTEATPGYRW 352
Score = 45.1 bits (105), Expect = 0.002
Identities = 69/303 (22%), Positives = 115/303 (37%), Gaps = 57/303 (18%)
Query: 28 QIIPKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITCD 87
Q + +V I P GS+ G T L+I G GFS+ + + +GN +CD
Sbjct: 1193 QYLTEVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVL----VGNR----------SCD 1238
Query: 88 VEKDASHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTPT 147
+ S I C T P+ +P T + W +P+
Sbjct: 1239 IVNLTEAS--IWCETLPAPQ-----------IPDAGAPTVPAAVEVWAGNRFFARGPSPS 1285
Query: 148 IRS-----ITPLSGTPGTLITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLI 202
+ + + TP + +QG ++ S+++L G N+ + +G + C++
Sbjct: 1286 LVGKGFTFMYEAAATP-VVTAMQG----EITNSSLSLHVGGSNLSNSVILLGNLNCDVET 1340
Query: 203 PQSDNLYGLKLDHPNGDMGSMVCKTTGTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLNK 262
L +G I H++ + Y QK F +
Sbjct: 1341 QSFQGNVSL----------------SGCSIPLHSLEAGI---YPLQVRQKQMGFANMSVV 1381
Query: 263 IAMFQTYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRV-LVGGEPCDILNVTENSI 321
+ F + IFPSQGS GGT LT+ G + VRV L G C IL++ +++I
Sbjct: 1382 LQQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCVILSLGDHTI 1441
Query: 322 CCK 324
C+
Sbjct: 1442 LCQ 1444
Score = 41.6 bits (96), Expect = 0.017
Identities = 30/115 (26%), Positives = 58/115 (50%), Gaps = 15/115 (13%)
Query: 1117 LKCQILNGSAGHAPVAVSMADVGL------AQNVGGEEFYFVYQ--SQISHIWPDSGSIA 1168
L+C + G V+ S+ + G A + ++ F+YQ S+I ++P++GS+
Sbjct: 213 LQCHVEGDYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLFLYQTHSEILSVFPETGSLG 272
Query: 1169 GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITC--RTPKKTEGTVDISVTT 1221
G T +T++G F+ +++V + C++ +I C R P K D+ +TT
Sbjct: 273 GRTNITITGDFFDNSAQVTIAGIPCDIRHVSPRKIECTTRAPGK-----DVRLTT 322
Score = 39.7 bits (91), Expect = 0.064
Identities = 65/299 (21%), Positives = 115/299 (38%), Gaps = 58/299 (19%)
Query: 29 IIPKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITCDV 88
++P++ I P GS G T LT+RG + + + VD + V L +I C V
Sbjct: 1387 VMPRIMAIFPSQGSACGGTILTVRGL-LLNSRRRSVRVDLSGPFTCVILSLGDHTILCQV 1445
Query: 89 EKDASHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTPTI 148
+ +P S+++ V+V +T + C+G+ CT + +P +
Sbjct: 1446 SLEGD----------PLPGASFSLNVTVLVNGLT--SECQGN-----CTLFIREEASPVM 1488
Query: 149 RSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLIPQSDNL 208
+++ + T G+L T+ + G +A +++ V + +PC + + +
Sbjct: 1489 DALS--TNTSGSLTTVL------IRGQRLATTADEPMVFV----DDQLPCNVTFFNASH- 1535
Query: 209 YGLKLDHPNGDMGSMVCKTTGTFIGHHNVS-FILDNDYGRSFPQKMAYFVSSLNKIAMFQ 267
+VC+T G H +S F N Y S N F
Sbjct: 1536 --------------VVCQTRDLAPGPHYLSVFYTRNGY-----------ACSGNVSRHFY 1570
Query: 268 TYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTP 326
+V FP S+ GG+ LTI G + V + + C +N+ I C P
Sbjct: 1571 IMPQVFHYFPKNFSLHGGSLLTIEGTGL-RGQNTTSVYIDQQTCLTVNIGAELIRCIVP 1628
Score = 36.2 bits (82), Expect = 0.71
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 2093 ITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDA 2148
I +V P+ GS G T +T+ G F + + +TIA CD+ + + I C T A
Sbjct: 261 ILSVFPETGSLGGRTNITITGDFFDNSAQ---VTIAGIPCDIRHVSPRKIECTTRA 313
Score = 35.0 bits (79), Expect = 1.6
Identities = 31/121 (25%), Positives = 56/121 (46%), Gaps = 13/121 (10%)
Query: 1600 IGSYPCVVEESSEDSITCHIDPQNSMDVGIRETVTLTVYNLGTAI----NTLSNEFDRRF 1655
+GS + E+ ++ CH++ D + V+ +V+N G ++ L + F
Sbjct: 198 MGSCYPIQEDHGLGTLQCHVEG----DYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLF 253
Query: 1656 VLLPNIDL--VLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECE 1713
+ + ++ V P GS G T++TI G F S+ +V + PC + V+ IEC
Sbjct: 254 LYQTHSEILSVFPETGSLGGRTNITITGDFFDNSA---QVTIAGIPCDIRHVSPRKIECT 310
Query: 1714 T 1714
T
Sbjct: 311 T 311
>gi|7019555 transmembrane protein 2 isoform a [Homo sapiens]
Length = 1383
Score = 166 bits (421), Expect = 3e-40
Identities = 109/350 (31%), Positives = 164/350 (46%), Gaps = 65/350 (18%)
Query: 2309 GERILILQEAVTWKPGDNIVIASTGHRHSQGENEKMTIASVSADGINITLSNPLNYTHLG 2368
G ++ +L + +WKPGD IV+AST + Q E + S + + + H+G
Sbjct: 415 GVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCS-ECSHFQVKVKETPQFLHMG 473
Query: 2369 ITVTLPDGTLFEARAEVGILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKF 2428
+ DG + RAEVGILTRNI+I+G +C
Sbjct: 474 EII---DGV--DMRAEVGILTRNIVIQGE---------------------VEDSCYAENQ 507
Query: 2429 GEEIGSDQFGGCVMFHAPVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFK- 2487
+ D FGG +M N + + YVE+ H GQ ++GRYP+H+HL GD+ +K
Sbjct: 508 CQFFDYDTFGGHIMIMK-----NFTSVHLSYVELKHMGQQ-QMGRYPVHFHLCGDVDYKG 561
Query: 2488 -----SYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNL 2542
++V G +IH +++R +T+H T+ LL++ I +D G FF+EDGIE N L +NL
Sbjct: 562 GYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNL 621
Query: 2543 AVFVQQSTSL------------------------LNDDVTPAAFWVTNPNNTIRHNAVAG 2578
+ + T L D + + FW+ +PNN + +NA AG
Sbjct: 622 GLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAG 681
Query: 2579 GTHFGFWYRMNNHPDGPSYDRNICQK--RVPLGEFFNNTVHSQGWFGMWI 2626
G WY + P G S + K PLG F+NN VHS G++I
Sbjct: 682 SQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFI 731
Score = 72.0 bits (175), Expect = 1e-11
Identities = 59/206 (28%), Positives = 94/206 (45%), Gaps = 32/206 (15%)
Query: 3179 GSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILH-DHKILILNDSLSYTHFAE 3237
G K+ L D W+ G++IV+ +T Y +Q E +++ H + + ++ + H E
Sbjct: 415 GVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGE 474
Query: 3238 KYHVPGTGESYTLAADVGILSRNIKIVGEDYPG---------WSEDSFGARVLVGSFTEN 3288
+ + A+VGIL+RNI I GE + D+FG +++
Sbjct: 475 II------DGVDMRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMI------ 522
Query: 3289 MMTFKGNARISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHG----SSYIRGCAFHH 3344
M F + +S VE H GQ+ RY V F G + G ++++ G + HH
Sbjct: 523 MKNFT-SVHLSYVELKHMGQQQMG-----RYPVHFHLCGDVDYKGGYRHATFVDGLSIHH 576
Query: 3345 GFSPAIGVFGTDGLDIDDNIIHFTVG 3370
FS I V GT+GL I D I T+G
Sbjct: 577 SFSRCITVHGTNGLLIKDTIGFDTLG 602
Score = 63.5 bits (153), Expect = 4e-09
Identities = 42/115 (36%), Positives = 60/115 (52%), Gaps = 8/115 (6%)
Query: 2198 VVITKGQTILLDQSTPILKMLLIQGGTLIFDE-----ADIELQAENILITDGGVLQIGTE 2252
VVI +G + L + +++ GG L+F + +I L+ ILI DGG L IG E
Sbjct: 133 VVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAE 192
Query: 2253 TSPFQHKAVITLHGHLRSPE-LPVYGAKTLAVRE-GILDLHGVPVPVTWTRLAHT 2305
++ KA ITL+G E +P +G K + V G L+LHG +WT LA T
Sbjct: 193 KCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGAR-KASWTLLART 246
Score = 35.8 bits (81), Expect = 0.93
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 12/116 (10%)
Query: 3744 IIRDSTCKYLPEWQSYQCFGMEYAMMVIESLDPDTETRRLSPVAIMGNGYVDLINGPQDH 3803
+IR +C + +W + C G YA + +++ T+ LS + I + Y P +
Sbjct: 972 LIRHPSCVNVSKWNAVICSGT-YAQVYVQTWS----TQNLS-MTITRDEY------PSNP 1019
Query: 3804 GWCAGYTCQRRLSLFHSIVALNKSYEVYFTGTSPQNLRLMLLNVDHNKAVLVGIFF 3859
G + + +V L K Y +++ G +P+ L L+N + N + VG+ +
Sbjct: 1020 MVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCY 1075
>gi|209447096 transmembrane protein 2 isoform b [Homo sapiens]
Length = 1320
Score = 143 bits (361), Expect = 3e-33
Identities = 94/295 (31%), Positives = 139/295 (47%), Gaps = 64/295 (21%)
Query: 2364 YTHLGITVTLPDGTLFEARAEVGILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTC 2423
+ H+G + DG + RAEVGILTRNI+I+G +C
Sbjct: 406 FLHMGEII---DGV--DMRAEVGILTRNIVIQGE---------------------VEDSC 439
Query: 2424 LQGKFGEEIGSDQFGGCVMFHAPVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGD 2483
+ D FGG +M N + + YVE+ H GQ ++GRYP+H+HL GD
Sbjct: 440 YAENQCQFFDYDTFGGHIMIMK-----NFTSVHLSYVELKHMGQQ-QMGRYPVHFHLCGD 493
Query: 2484 LQFK------SYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNI 2537
+ +K ++V G +IH +++R +T+H T+ LL++ I +D G FF+EDGIE N
Sbjct: 494 VDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNT 553
Query: 2538 LQYNLAVFVQQSTSL------------------------LNDDVTPAAFWVTNPNNTIRH 2573
L +NL + + T L D + + FW+ +PNN + +
Sbjct: 554 LFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLIN 613
Query: 2574 NAVAGGTHFGFWYRMNNHPDGPSYDRNICQK--RVPLGEFFNNTVHSQGWFGMWI 2626
NA AG G WY + P G S + K PLG F+NN VHS G++I
Sbjct: 614 NAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFI 668
Score = 63.5 bits (153), Expect = 4e-09
Identities = 42/115 (36%), Positives = 60/115 (52%), Gaps = 8/115 (6%)
Query: 2198 VVITKGQTILLDQSTPILKMLLIQGGTLIFDE-----ADIELQAENILITDGGVLQIGTE 2252
VVI +G + L + +++ GG L+F + +I L+ ILI DGG L IG E
Sbjct: 133 VVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAE 192
Query: 2253 TSPFQHKAVITLHGHLRSPE-LPVYGAKTLAVRE-GILDLHGVPVPVTWTRLAHT 2305
++ KA ITL+G E +P +G K + V G L+LHG +WT LA T
Sbjct: 193 KCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGAR-KASWTLLART 246
Score = 54.3 bits (129), Expect = 3e-06
Identities = 44/134 (32%), Positives = 63/134 (47%), Gaps = 25/134 (18%)
Query: 3250 LAADVGILSRNIKIVGEDYPG---------WSEDSFGARVLVGSFTENMMTFKGNARISN 3300
+ A+VGIL+RNI I GE + D+FG +++ M F + +S
Sbjct: 418 MRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMI------MKNFT-SVHLSY 470
Query: 3301 VEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHG----SSYIRGCAFHHGFSPAIGVFGTD 3356
VE H GQ+ RY V F G + G ++++ G + HH FS I V GT+
Sbjct: 471 VELKHMGQQQMG-----RYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTN 525
Query: 3357 GLDIDDNIIHFTVG 3370
GL I D I T+G
Sbjct: 526 GLLIKDTIGFDTLG 539
Score = 35.8 bits (81), Expect = 0.93
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 12/116 (10%)
Query: 3744 IIRDSTCKYLPEWQSYQCFGMEYAMMVIESLDPDTETRRLSPVAIMGNGYVDLINGPQDH 3803
+IR +C + +W + C G YA + +++ T+ LS + I + Y P +
Sbjct: 909 LIRHPSCVNVSKWNAVICSGT-YAQVYVQTWS----TQNLS-MTITRDEY------PSNP 956
Query: 3804 GWCAGYTCQRRLSLFHSIVALNKSYEVYFTGTSPQNLRLMLLNVDHNKAVLVGIFF 3859
G + + +V L K Y +++ G +P+ L L+N + N + VG+ +
Sbjct: 957 MVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCY 1012
>gi|38638698 KIAA1199 [Homo sapiens]
Length = 1361
Score = 141 bits (355), Expect = 2e-32
Identities = 155/617 (25%), Positives = 239/617 (38%), Gaps = 132/617 (21%)
Query: 2312 ILILQEAV-TWKPGDNIVIASTGHRHSQGENEKMTIASVSADGINITLSNPLNYTHLGIT 2370
IL L++ V +WKPGD +VIAST + Q E E + S + ++ Y H+G
Sbjct: 423 ILNLEDNVQSWKPGDTLVIASTDYSMYQAE-EFQVLPCRSCAPNQVKVAGKPMYLHIGEE 481
Query: 2371 VTLPDGTLFEARAEVGILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGE 2430
+ DG + RAEVG+L+RNI++ G E +K + C F
Sbjct: 482 I---DGV--DMRAEVGLLSRNIIVMG----EMEDKCYP---------YRNHICNFFDF-- 521
Query: 2431 EIGSDQFGGCVMFHAPVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFK--- 2487
D FGG + F A++ E E+ H GQ +G+YPIH+HL GD+ +
Sbjct: 522 ----DTFGGHIKFALGFKAAHL-----EGTELKHMGQQL-VGQYPIHFHLAGDVDERGGY 571
Query: 2488 ---SYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAV 2544
+Y+R +IH ++R VT+H ++ LL++ + Y+ G FF EDG E N + L +
Sbjct: 572 DPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGL 631
Query: 2545 FVQQST-----------SLLNDDVTP-------------AAFWVTNPNNTIRHNAVAGGT 2580
V+ T ++ +D P + FW+ NPNN + + A AG
Sbjct: 632 LVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSE 691
Query: 2581 HFGFWYRMNNHPDGPSYDRNI--CQKRVPLGEFFNNTVHSQGWFGM-------------- 2624
GFW+ ++ P GPS + +PLG+F+NN HS GM
Sbjct: 692 ETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAK 751
Query: 2625 -------WIFEEYFPMQTGSCTSTVPAPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVN 2677
I Y P Q PAI + Q W+ GG + + +
Sbjct: 752 DKRPFLSIISARYSPHQDADPLKP-REPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFAD 810
Query: 2678 NYEAGIETKRILAPYVGGWGETNGAVIKNAKIVGHLDELG--------MGSAFCTAKGLV 2729
N PY G + IKN+ VG +G G G
Sbjct: 811 NGIGLTLASGGTFPYDDG----SKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRT 866
Query: 2730 LPFSEGLTVSSVHFMNFDRP----NC-----VALGVTSISGVCNDRCGGWSA----KFVD 2776
LP + + + +D P NC VAL S + W +
Sbjct: 867 LPIGQNFPIRGIQL--YDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTG 924
Query: 2777 VQYSHTP--------------NKAGFRWEHEMVMIDVDGSLTGHKGHTVIPHSS-LLDPS 2821
+ + P N+ + V DVDGS++ + G + + + L+
Sbjct: 925 IAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKNDNWLVRHP 984
Query: 2822 HCTQEAEWSIGFPGSVC 2838
C +W G++C
Sbjct: 985 DCINVPDWR----GAIC 997
Score = 74.7 bits (182), Expect = 2e-12
Identities = 162/767 (21%), Positives = 277/767 (36%), Gaps = 190/767 (24%)
Query: 3180 SKVLSLMDAVD-WQEGEEIVITTTSYDFHQTETRSIV--KILHDHKILILNDSLSYTHFA 3236
S +L+L D V W+ G+ +VI +T Y +Q E ++ + +++ + + Y H
Sbjct: 421 STILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPM-YLHIG 479
Query: 3237 EKYHVPGTGESYTLAADVGILSRNIKIVGED----YPGWSE-------DSFGARVLVGSF 3285
E+ + + A+VG+LSRNI ++GE YP + D+FG +
Sbjct: 480 EEI------DGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFA-- 531
Query: 3286 TENMMTFKGNARISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGS----SYIRGCA 3341
+ FK A + E H GQ+ +Y + F G + E G +YIR +
Sbjct: 532 ----LGFKA-AHLEGTELKHMGQQ-----LVGQYPIHFHLAGDVDERGGYDPPTYIRDLS 581
Query: 3342 FHHGFSPAIGVFGTDGLDIDDNIIHFTVG------------------------EGIRIWG 3377
HH FS + V G++GL I D + + ++G G +
Sbjct: 582 IHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPS 641
Query: 3378 NANRVRGNLIALSVWPGTY-QNRKDLS--STLWHAAIEINRGTNTVLQNNVVAGFGRAGY 3434
+ + +I +PG + R+D + ST W A N N + GF +
Sbjct: 642 DRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPN-NNLINCAAAGSEETGFWFIFH 700
Query: 3435 RIDGEPCPGQFN-------PVEKWFDNEAHGGL--------------------------- 3460
+ P G ++ P+ K+++N AH
Sbjct: 701 HVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSII 760
Query: 3461 ---YGIYMNQDGLP--GCSLIQGFTIWTCWDYGIYFQTTESVHIYNVTLVDNGMAIFPMI 3515
Y + + D L ++I+ F + D+G + + + V + + DNG+ + +
Sbjct: 761 SARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRGGD-VWLDSCRFADNGIGL--TL 817
Query: 3516 YMPAAISHKISSKNVQIKSSLIVGSSPGFNCSDVLTNDDPNIELTAAHRSPRSPSG-GRS 3574
+ SK +IK+SL VG S N+ P G S
Sbjct: 818 ASGGTFPYDDGSKQ-EIKNSLFVGES-------------GNVGTEMMDNRIWGPGGLDHS 863
Query: 3575 GICWPTFASAHNMAPRKPHAGIMSYNAISGLLDISGSTFVGFKNVCSGETNVI-FITNPL 3633
G P + P GI Y+ G ++I TF F + T+ + F N
Sbjct: 864 GRTLP-------IGQNFPIRGIQLYD---GPINIQNCTFRKFVALEGRHTSALAFRLNNA 913
Query: 3634 NEDLQHPIHVKNIKLVDTTEQSKIFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFL 3693
+ H +V I D S++F P N D D + S D+DGS
Sbjct: 914 WQSCPHN-NVTGIAFEDVPITSRVFFGEPG-PWFNQLD-----MDGDKTSVFHDVDGSVS 966
Query: 3694 GNAGSVIPQAEYEWDGNSQVGIGDYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYL 3753
GS + + + W ++R C +
Sbjct: 967 EYPGSYLTKND-NW------------------------------------LVRHPDCINV 989
Query: 3754 PEWQSYQCFGMEYAMMVIESLDPDTETRRLSPVAIMGNGYVDLINGPQDHGWCAG-YTCQ 3812
P+W+ C G YA M I++ T R+ I+ N + P + G T
Sbjct: 990 PDWRGAICSGC-YAQMYIQAY--KTSNLRMK---IIKNDF------PSHPLYLEGALTRS 1037
Query: 3813 RRLSLFHSIVALNKSYEVYFTGTSPQNLRLMLLNVDHNKAVLVGIFF 3859
+ +V L K Y +++ T+P L + L+N + + VG+ +
Sbjct: 1038 THYQQYQPVVTLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCY 1084
Score = 57.8 bits (138), Expect = 2e-07
Identities = 42/118 (35%), Positives = 62/118 (52%), Gaps = 8/118 (6%)
Query: 2198 VVITKGQTILLDQSTPILKMLLIQGGTLIFDEAD--IELQAENILITDGGVLQIGTETSP 2255
V I +G+T+LL S + + + +GG L+ + D I L+ +ILI +GG L G+ P
Sbjct: 56 VHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCP 115
Query: 2256 FQHKAVITLHGHLR---SPELPVYGAKTLAV-REGILDLHGVPVPVTWTRLAHTAKAG 2309
FQ I L+G P+ P YG K + V + G L+LHG ++WT L T G
Sbjct: 116 FQGNFTIILYGRADEGIQPD-PYYGLKYIGVGKGGALELHG-QKKLSWTFLNKTLHPG 171
>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
Length = 1390
Score = 71.2 bits (173), Expect = 2e-11
Identities = 65/264 (24%), Positives = 107/264 (40%), Gaps = 32/264 (12%)
Query: 1055 GDCGFTWDSNITPLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVGCSLLSVDE 1114
G ++ S + P++ +ISP G GT+LT+ G+ + ++ +S+G C+L SV
Sbjct: 645 GTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSN 704
Query: 1115 KELKCQILNGSAGHAPVAVSMADVGLAQNV---GGEEFYFVYQSQ--ISHIWPDSGSIAG 1169
L+C + P + + + E F Y+ + I P I+G
Sbjct: 705 SILEC--------YTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISG 756
Query: 1170 GTLLTLSGFGFNENSKVLVGNETCNVIEGDLN------------RITCRTPKKTEGTVDI 1217
G+ T++G G N NS V V NV E N I C TP + + +
Sbjct: 757 GS--TITGVGKNLNS-VSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQL 813
Query: 1218 SVTTNGF---QATARDAFSYNCLQTPIITDFSPKVRTILGEVN-LTIKGYNFGNELTQNM 1273
+ T F F + P+ F V +G N L IKG + E +
Sbjct: 814 PLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGE 873
Query: 1274 AVYVGGKTCQILHWNFTDIRCLLP 1297
+ VG K+C+ +H + + C +P
Sbjct: 874 VLKVGNKSCENIHLHSEAVLCTVP 897
Score = 67.4 bits (163), Expect = 3e-10
Identities = 50/155 (32%), Positives = 75/155 (48%), Gaps = 21/155 (13%)
Query: 1157 ISHIWPDSGSIAGGTLLTLSG--FGFNENSK-------VLVGNETCNVI--EGDLNRITC 1205
I ++P+S + GGT LT+ G FGF N+K VL+GNE+C + E +N + C
Sbjct: 565 IYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKC 624
Query: 1206 RTPKKTEGTVDIS-VTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKG-- 1262
++S + +NG T FSY P+IT SPK + G LT+ G
Sbjct: 625 TVGPAMNKHFNMSIIISNGHGTTQYSTFSY---VDPVITSISPKYGPMAGGTLLTLTGNY 681
Query: 1263 YNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLP 1297
N GN + + +GGKTC + + + + C P
Sbjct: 682 LNSGN----SRHISIGGKTCTLKSVSNSILECYTP 712
Score = 65.1 bits (157), Expect = 1e-09
Identities = 78/343 (22%), Positives = 138/343 (40%), Gaps = 40/343 (11%)
Query: 1749 PYITGVFPNS--VIGSVKVLIEGEGLGTV------LEDIAVFIGNQQ--FRAIEVNENNI 1798
P I VFPNS + G ++ I G G L+ V +GN+ E N +
Sbjct: 563 PAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTL 622
Query: 1799 TALVTPLPVGHHSVSVVV--GSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGF 1856
V P H ++S+++ G + P + S+SP G + GGT L +TGN
Sbjct: 623 KCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYL 682
Query: 1857 YPGNTT-VTIGDEPCQIISINPNEVYCRTPAGTTGM-VDVKIFVNTIAYPPLLFTYALED 1914
GN+ ++IG + C + S++ + + C TPA T VK+ ++ +F+Y +
Sbjct: 683 NSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSY--RE 740
Query: 1915 TPFLRGIIPSRGPPGTEIEITGSNFGFEILEISVMINNIQ---CNVTMA-----NDSVVQ 1966
P + I P++ ITG + + M+ N+ N T+A N ++
Sbjct: 741 DPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIIC 800
Query: 1967 CIVGDHAGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNIN---------PSQGSFGGGQTM 2017
C + + KTK M + ++ ++ P S G +
Sbjct: 801 CTTPSLQ--QLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVL 858
Query: 2018 TVTGTGFNPQ---NSIILVCGSECAIDRLRSDYTTLLCEIPSN 2057
+ G +P+ ++ V C L S+ +LC +P++
Sbjct: 859 EIKGNDIDPEAVKGEVLKVGNKSCENIHLHSE--AVLCTVPND 899
Score = 58.5 bits (140), Expect = 1e-07
Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 19/162 (11%)
Query: 2001 IQNINPSQGSFGGGQTMTVTGT--GFNPQNSI------ILVCGSECAIDRLRSDYTTLLC 2052
I + P+ GG +T+ G GF N +L+ C + S TL C
Sbjct: 565 IYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKC 624
Query: 2053 EIPSNNGTGAEQACEVSVV--NGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLT 2110
+ G + +S++ NG +Q T F+Y + P+IT++SPK G AGGT LT
Sbjct: 625 TV----GPAMNKHFNMSIIISNGHGTTQYST-FSY---VDPVITSISPKYGPMAGGTLLT 676
Query: 2111 VVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLS 2152
+ G+ + + HI+I C ++ + + + C T A T+S
Sbjct: 677 LTGN-YLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTIS 717
Score = 57.4 bits (137), Expect = 3e-07
Identities = 59/249 (23%), Positives = 114/249 (45%), Gaps = 27/249 (10%)
Query: 1916 PFLRGIIPSRGP--PGTEIEITGSNFGF------EILEISVMINNIQCNVTMANDSV--V 1965
P + + P+ P GT + I G +FGF ++ + V++ N C +T++ ++ +
Sbjct: 563 PAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTL 622
Query: 1966 QCIVGDHAGGTF--PVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTG 2023
+C VG F +++ + + ST + P+ I +I+P G GG +T+TG
Sbjct: 623 KCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPV-ITSISPKYGPMAGGTLLTLTGNY 681
Query: 2024 FNPQNSI-ILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTP 2082
N NS I + G C + + + + L C P+ E A ++ + DL+ T
Sbjct: 682 LNSGNSRHISIGGKTCTLKSVSN--SILECYTPAQT-ISTEFAVKLKI----DLANRETS 734
Query: 2083 FTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGF-SENMEDVHITIAEA----KCDVEYS 2137
++ P++ + P + +GG+ +T VG S ++ + I + EA ++
Sbjct: 735 I-FSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHR 793
Query: 2138 NKTHIICMT 2146
+ + IIC T
Sbjct: 794 SNSEIICCT 802
Score = 47.8 bits (112), Expect = 2e-04
Identities = 43/175 (24%), Positives = 72/175 (41%), Gaps = 37/175 (21%)
Query: 153 PLSGTPGTLITIQGRIFTDVYGSNIALSSNGK-NVRILRVYIGGMPCELLIPQSDNLYGL 211
PL G GT +TI G F N K +++ RV +G C L + +S
Sbjct: 574 PLEG--GTRLTICGWDF--------GFRRNNKFDLKKTRVLLGNESCTLTLSEST----- 618
Query: 212 KLDHPNGDMGSMVCKTTGTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLNKIAMFQTYAE 271
M ++ C H N+S I+ N +G + +Y
Sbjct: 619 --------MNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSY------------VDPV 658
Query: 272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTP 326
+T I P G + GGT LT++G + + + + +GG+ C + +V+ + + C TP
Sbjct: 659 ITSISPKYGPMAGGTLLTLTGNYLNSGN-SRHISIGGKTCTLKSVSNSILECYTP 712
Score = 40.8 bits (94), Expect = 0.029
Identities = 72/310 (23%), Positives = 107/310 (34%), Gaps = 80/310 (25%)
Query: 30 IPKVTEIIPKYGSINGATRLTIRG--EGFSQANQFNYGVDNAELGNSVQLISSFQSITCD 87
+P + ++ P + G TRLTI G GF + N+F+ LGN +C
Sbjct: 562 LPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNE----------SCT 611
Query: 88 VEKDASHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTPT 147
+ S + C + + + + GH + TF S+ P
Sbjct: 612 LTLSESTMNTLKCTVGPAMNKHFNMSIIIS----------NGHGTTQYSTF---SYVDPV 658
Query: 148 IRSITPLSG--TPGTLITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLIPQS 205
I SI+P G GTL+T+ G N S N +++ IGG C L +
Sbjct: 659 ITSISPKYGPMAGGTLLTLTG---------NYLNSGNSRHIS-----IGGKTCTLKSVSN 704
Query: 206 DNLYGLKLDHPNGDMGSMVCKTTGTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLNKIAM 265
L C T I F K+ + N+
Sbjct: 705 SIL---------------ECYTPAQTI-------------STEFAVKLK--IDLANRETS 734
Query: 266 FQTYAE---VTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVT----E 318
+Y E V I P++ I GG+T+T G+ + P V+ E V
Sbjct: 735 IFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRS 794
Query: 319 NS--ICCKTP 326
NS ICC TP
Sbjct: 795 NSEIICCTTP 804
Score = 37.7 bits (86), Expect = 0.24
Identities = 34/151 (22%), Positives = 65/151 (43%), Gaps = 11/151 (7%)
Query: 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQNM-----AVYVGGKTCQILHWNFT--DI 1292
P I P + G LTI G++FG V +G ++C + T +
Sbjct: 563 PAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTL 622
Query: 1293 RCLLPKLSPGKHDIYVEVRNWGFASTRDKLNSSIQYVLEVTSMFPQRGSLFGGTEITIRG 1352
+C + ++ + + N G +T+ S + V +TS+ P+ G + GGT +T+ G
Sbjct: 623 KCTVGPAMNKHFNMSIIISN-GHGTTQYSTFSYVDPV--ITSISPKYGPMAGGTLLTLTG 679
Query: 1353 FGFSTIPAENTVLLGSIPCNVTSSSENVIKC 1383
+ + +G C + S S ++++C
Sbjct: 680 -NYLNSGNSRHISIGGKTCTLKSVSNSILEC 709
Score = 34.7 bits (78), Expect = 2.1
Identities = 29/95 (30%), Positives = 47/95 (49%), Gaps = 12/95 (12%)
Query: 1332 VTSMFPQRGSLFGGTEITIRG--FGF---STIPAENT-VLLGSIPCNVT--SSSENVIKC 1383
+ +FP L GGT +TI G FGF + + T VLLG+ C +T S+ N +KC
Sbjct: 565 IYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKC 624
Query: 1384 ----ILHSTGNIFRITNNGKDSVHGLGYAWSPPVL 1414
++ N+ I +NG + +++ PV+
Sbjct: 625 TVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVI 659
Score = 33.1 bits (74), Expect = 6.0
Identities = 30/92 (32%), Positives = 42/92 (45%), Gaps = 18/92 (19%)
Query: 27 SQIIPKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITC 86
S + P +T I PKYG + G T LT+ G NY GNS + S TC
Sbjct: 653 SYVDPVITSISPKYGPMAGGTLLTLTG---------NY----LNSGNSRHI--SIGGKTC 697
Query: 87 DVEKDASHSTQITCYTRAMP-EDSYTVRVSVD 117
+ K S+S + CYT A + V++ +D
Sbjct: 698 TL-KSVSNSI-LECYTPAQTISTEFAVKLKID 727
>gi|113722116 plexin A2 [Homo sapiens]
Length = 1894
Score = 69.7 bits (169), Expect = 6e-11
Identities = 99/411 (24%), Positives = 164/411 (39%), Gaps = 75/411 (18%)
Query: 1067 PLVLAISPSQGSYEEGTILTI----VGSGFSPSSAVTVSVGPVGCSLLS---VDEKELKC 1119
P + I G E GT +TI +G FS A V V V C+ L + +++ C
Sbjct: 858 PQITEILTVSGPPEGGTRVTIHGVNLGLDFS-EIAHHVQVAGVPCTPLPGEYIIAEQIVC 916
Query: 1120 QILNGSAGHAPVAVSMADVGLA--------QNVGGEEFYFVYQSQISHIWPDSGSIAGGT 1171
++ GHA V + V L +++ FV S +S + P G +GGT
Sbjct: 917 EM-----GHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLS-LNPIRGPESGGT 970
Query: 1172 LLTLSGFGFNENSKVLV--GNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQATAR 1229
++T++G S V V GN+TC ++ I C +P + G + V+ + +A
Sbjct: 971 MVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVD 1030
Query: 1230 DAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGGK----TCQIL 1285
+ + P + P+ G LTI G+N + V GK C+++
Sbjct: 1031 SNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVV 1090
Query: 1286 HWNFTDIRCLLPKLS----PGKHDIYVEVRNWGFASTRDKLNSSIQY------------- 1328
N T + CL P L+ PG D +GF + + S + Y
Sbjct: 1091 --NTTTLTCLAPSLTTDYRPGL-DTVERPDEFGFVF--NNVQSLLIYNDTKFIYYPNPTF 1145
Query: 1329 -VLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAEN------TVLLGSIPCNVTSSSENVI 1381
+L T + Q+ G+ I ++G PA TVL+G PC VT S ++
Sbjct: 1146 ELLSPTGVLDQK----PGSPIILKGKNLCP-PASGGAKLNYTVLIGETPCAVTVSETQLL 1200
Query: 1382 ----------KCILHSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTV 1422
K ++H G +F + G SV P +++++ G ++
Sbjct: 1201 CEPPNLTGQHKVMVHVGGMVF---SPGSVSVISDSLLTLPAIVSIAAGGSL 1248
Score = 57.4 bits (137), Expect = 3e-07
Identities = 75/340 (22%), Positives = 129/340 (37%), Gaps = 44/340 (12%)
Query: 1761 GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKG 1820
G +V I G LG +IA + + I A +GH V G
Sbjct: 872 GGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVR 931
Query: 1821 LALGNL------------TVSSPPVASLSPTSGSIGGGTTLVITGNGFYPGNT-TVTIGD 1867
L +G T +P V SL+P G GGT + ITG+ G++ V +G+
Sbjct: 932 LCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGN 991
Query: 1868 EPCQIISINPNEVYCRTPAGTTGMVDVKIFVNT-IAYPPLLFTYALEDTPFLRGIIPSRG 1926
+ C+ + +E+ C +P + G+ V + V+ A+ + D P ++ I P
Sbjct: 992 QTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWS 1051
Query: 1927 PPGTEIEITGSNFGFEILE---ISVMINNIQ-CNV-TMANDSVVQCIV------------ 1969
+T + F ++++ I V N + NV + N + + C+
Sbjct: 1052 IASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLD 1111
Query: 1970 ----GDHAGGTF----PVMMHHKTKGSAMSTVVFEY--PLNIQNINPSQGSFGGGQTMTV 2019
D G F +++++ TK FE P + + P G+ +
Sbjct: 1112 TVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCP 1171
Query: 2020 TGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNNG 2059
+G N +L+ + CA+ T LLCE P+ G
Sbjct: 1172 PASGGAKLNYTVLIGETPCAV---TVSETQLLCEPPNLTG 1208
Score = 50.1 bits (118), Expect = 5e-05
Identities = 64/259 (24%), Positives = 104/259 (40%), Gaps = 34/259 (13%)
Query: 1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEIS--VMINNIQCNVTMANDSVVQ---CI 1968
P + I+ GPP GT + I G N G + EI+ V + + C + + C
Sbjct: 858 PQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCE 917
Query: 1969 VGDHAGGTF--PVMM-------HHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTV 2019
+G GT PV + TK T V ++ ++NP +G GG +T+
Sbjct: 918 MGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNP---SVLSLNPIRGPESGGTMVTI 974
Query: 2020 TGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQS 2079
TG +S+ + G++ RS + PS+NG G VSV + S
Sbjct: 975 TGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLG---PVPVSVSVDRAHVDS 1031
Query: 2080 MTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNK 2139
F Y P + + P+ +G T LT+ G I E + V+++ K
Sbjct: 1032 NLQFEYIDD--PRVQRIEPEWSIASGHTPLTITGFNLD--------VIQEPRIRVKFNGK 1081
Query: 2140 THI-IC-MTDAHTLSGWAP 2156
+ +C + + TL+ AP
Sbjct: 1082 ESVNVCKVVNTTTLTCLAP 1100
Score = 48.5 bits (114), Expect = 1e-04
Identities = 66/275 (24%), Positives = 107/275 (38%), Gaps = 33/275 (12%)
Query: 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAA 1718
P++ + P G +G T VTI G S+ V V +G+ C+ + + I C + P++
Sbjct: 954 PSVLSLNPIRGPESGGTMVTITGHYLGAGSS-VAVYLGNQTCEFYGRSMSEIVCVSPPSS 1012
Query: 1719 QQLVDVDLLIHGVPAQCQGNCTFSYLESITPYITGVFPNSVI--GSVKVLIEGEGLGTVL 1776
L V + + A N F Y++ P + + P I G + I G L +
Sbjct: 1013 NGLGPVPVSVSVDRAHVDSNLQFEYIDD--PRVQRIEPEWSIASGHTPLTITGFNLDVIQ 1070
Query: 1777 ED-IAV-FIGNQQFRAIE-VNENNITALVTPLPVGH--------------------HSVS 1813
E I V F G + + VN +T L L + S+
Sbjct: 1071 EPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLL 1130
Query: 1814 VVVGSKGLALGNLT---VSSPPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEPC 1870
+ +K + N T +S V P S I G L +G N TV IG+ PC
Sbjct: 1131 IYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPC 1190
Query: 1871 QIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPP 1905
++++ ++ C P TG V + V + + P
Sbjct: 1191 -AVTVSETQLLCE-PPNLTGQHKVMVHVGGMVFSP 1223
Score = 42.0 bits (97), Expect = 0.013
Identities = 82/375 (21%), Positives = 131/375 (34%), Gaps = 42/375 (11%)
Query: 1825 NLTVSSPPVASLSPTSGSIGGGTTLVI----TGNGFYPGNTTVTIGDEPCQIIS---INP 1877
N+ S+P + + SG GGT + I G F V + PC + I
Sbjct: 852 NVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIA 911
Query: 1878 NEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFTYALED----TPFLRGIIPSRGPP--GTE 1931
++ C G + + P T + + P + + P RGP GT
Sbjct: 912 EQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTM 971
Query: 1932 IEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVMMHHKT-KGSAM 1990
+ ITG G ++V + N C + S + C+ + G PV + +
Sbjct: 972 VTITGHYLGAG-SSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVD 1030
Query: 1991 STVVFEY--PLNIQNINPSQGSFGGGQTMTVTG------------TGFNPQNS-----II 2031
S + FEY +Q I P G +T+TG FN + S ++
Sbjct: 1031 SNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVV 1090
Query: 2032 LVCGSECAIDRLRSDYTTLL--CEIPSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSL 2089
C L +DY L E P G + + N P +S
Sbjct: 1091 NTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSP 1150
Query: 2090 TPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAH 2149
T ++ P G L SG ++ + + I E C V S +T ++C +
Sbjct: 1151 TGVLDQ-KPGSPIILKGKNLCPPASGGAK--LNYTVLIGETPCAVTVS-ETQLLC--EPP 1204
Query: 2150 TLSGWAPVCVHIRGV 2164
L+G V VH+ G+
Sbjct: 1205 NLTGQHKVMVHVGGM 1219
Score = 33.1 bits (74), Expect = 6.0
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPPKPHI 331
V + P +G GGT +TI+G + V V +G + C+ + + I C +PP +
Sbjct: 956 VLSLNPIRGPESGGTMVTITGHYLGAGS-SVAVYLGNQTCEFYGRSMSEIVCVSPPSSNG 1014
Query: 332 LKTV 335
L V
Sbjct: 1015 LGPV 1018
>gi|59710104 plexin A3 [Homo sapiens]
Length = 1871
Score = 69.3 bits (168), Expect = 8e-11
Identities = 85/347 (24%), Positives = 133/347 (38%), Gaps = 36/347 (10%)
Query: 1067 PLVLAISPSQGSYEEGTILTIVGSGFSP-SSAVTVSVGPVGCSLLS---VDEKELKCQI- 1121
P + I P G E GT +TIVG S V + V V C+ + + + + C++
Sbjct: 840 PRITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEME 899
Query: 1122 --LNGSAGHAPVAVSMADVGLAQNVGGEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFG 1179
L S PV + + D E+ Y + P G +GGT LT+SG
Sbjct: 900 ESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSS 959
Query: 1180 FNENSK--VLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQAT-ARDAFSYNC 1236
+ S+ V V + C + D I C +P T G +T +A + Y
Sbjct: 960 LDAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTY 1019
Query: 1237 LQTPIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGG----KTCQILHWNFTDI 1292
Q P +T P I G +T+ G + + G TCQ++ N T +
Sbjct: 1020 TQDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVI--NDTAM 1077
Query: 1293 RCLLPKLSPGKHDIYVEVRN---WGF----ASTRDKLNSSIQYVLEVTSMFPQRGS---- 1341
C P + G+ + + +GF T LN S S P S
Sbjct: 1078 LCKAPGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLD 1137
Query: 1342 LFGGTEITIRGFGFSTIPA-------ENTVLLGSIPCNVTSSSENVI 1381
+ G+ + ++ G + IPA TVL+G PC++T S ++
Sbjct: 1138 VKPGSHVVLK--GKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLL 1182
Score = 59.7 bits (143), Expect = 6e-08
Identities = 79/355 (22%), Positives = 136/355 (38%), Gaps = 48/355 (13%)
Query: 1749 PYITGVFP--NSVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIE---VNENNIT---- 1799
P IT + P G +V I G+ LG + ++ + + + +I ++ I
Sbjct: 840 PRITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEME 899
Query: 1800 -ALVTPLPVGHHSVSVVVGSKGLALGNLTVSS---PPVASLSPTSGSIGGGTTLVITGNG 1855
+LV P G + V S + V S P +SP+ G GGT L I+G+
Sbjct: 900 ESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSS 959
Query: 1856 FYPGN-TTVTIGDEPCQIISINPNEVYCRTPAGTTG----MVDVKIFVNTIAYPPLLFTY 1910
G+ TVT+ D CQ + + + C +P T G + + I I+ P L++TY
Sbjct: 960 LDAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTY 1019
Query: 1911 ALEDTPFLRGIIPSRGPPGTEIEITGSN-FGFEILEISVMINNIQCNVT--MANDSVVQC 1967
+ T S T I ++G++ + + I+ T + ND+ + C
Sbjct: 1020 TQDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLC 1079
Query: 1968 -------------IVGDHAGGTFPVMMHHKTKGSAMSTVVFEY----------PLNIQNI 2004
G+H F ++ H +++ F Y P + ++
Sbjct: 1080 KAPGIFLGRPQPRAQGEHP-DEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDV 1138
Query: 2005 NPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNNG 2059
P G+ + G + N +L+ G C+ L T LLC+ PS G
Sbjct: 1139 KPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCS---LTVSDTQLLCDSPSQTG 1190
Score = 52.0 bits (123), Expect = 1e-05
Identities = 53/206 (25%), Positives = 91/206 (44%), Gaps = 23/206 (11%)
Query: 1966 QCIVGDHAGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGT--G 2023
+C + H MH KG+ S +P I I+P G GG +T+ G G
Sbjct: 813 RCQLRTHCPAPKTNWMHLSQKGTRCS-----HP-RITQIHPLVGPKEGGTRVTIVGDNLG 866
Query: 2024 FNPQNSIILVCGSECAIDRLRSDYTT---LLCEIPSN----NGTGAEQACEVSVVNGKDL 2076
+ + V G C + + ++Y + ++CE+ + G + C V +
Sbjct: 867 LLSREVGLRVAGVRC--NSIPAEYISAERIVCEMEESLVPSPPPGPVELC-VGDCSADFR 923
Query: 2077 SQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEY 2136
+QS +++ +TP VSP RG +GGTRLT+ GS V +T+ +++C
Sbjct: 924 TQSEQVYSF---VTPTFDQVSPSRGPASGGTRLTISGSSLDAGSR-VTVTVRDSECQFVR 979
Query: 2137 SNKTHIICMTDAHTLS-GWAPVCVHI 2161
+ I+C++ TL AP+ + I
Sbjct: 980 RDAKAIVCISPLSTLGPSQAPITLAI 1005
Score = 51.2 bits (121), Expect = 2e-05
Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 7/132 (5%)
Query: 1053 CSGDCGFTWDSN-------ITPLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPV 1105
C GDC + + +TP +SPS+G GT LTI GS S VTV+V
Sbjct: 914 CVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDS 973
Query: 1106 GCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQNVGGEEFYFVYQSQISHIWPDSG 1165
C + D K + C + G + +++A + G + + ++ + P
Sbjct: 974 ECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYTQDPTVTRLEPTWS 1033
Query: 1166 SIAGGTLLTLSG 1177
I G T +T+SG
Sbjct: 1034 IINGSTAITVSG 1045
Score = 49.7 bits (117), Expect = 6e-05
Identities = 49/215 (22%), Positives = 86/215 (40%), Gaps = 24/215 (11%)
Query: 1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHA 1973
P + I P GP GT + I G N G E+ + + ++CN A + IV +
Sbjct: 840 PRITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEME 899
Query: 1974 GGTFP-------------VMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVT 2020
P +T+ + + V ++PS+G GG +T++
Sbjct: 900 ESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTP---TFDQVSPSRGPASGGTRLTIS 956
Query: 2021 GTGFNPQNSI-ILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQS 2079
G+ + + + + V SEC +R D ++C P + G QA ++ ++S
Sbjct: 957 GSSLDAGSRVTVTVRDSECQF--VRRDAKAIVCISPLST-LGPSQAPITLAIDRANISSP 1013
Query: 2080 MTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGS 2114
+TY P +T + P G T +TV G+
Sbjct: 1014 GLIYTYTQD--PTVTRLEPTWSIINGSTAITVSGT 1046
Score = 36.6 bits (83), Expect = 0.55
Identities = 71/361 (19%), Positives = 120/361 (33%), Gaps = 72/361 (19%)
Query: 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAA 1718
P I + P G G T VTI G + S V + + C + Y + E
Sbjct: 840 PRITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEME 899
Query: 1719 QQLVDVDLLIHGVPAQCQGNCTFSY---LESITPYITGVFP------NSVIGSVKVLIEG 1769
+ LV G C G+C+ + E + ++T F G ++ I G
Sbjct: 900 ESLVPSP--PPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISG 957
Query: 1770 EGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNLTVS 1829
L + V + + + + + + I + +G + LA+ +S
Sbjct: 958 SSLDAG-SRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPIT-----LAIDRANIS 1011
Query: 1830 S----------PPVASLSPTSGSIGGGTTLVITGNGF-----------YPGNTTVTIGDE 1868
S P V L PT I G T + ++G Y G T
Sbjct: 1012 SPGLIYTYTQDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETT----N 1067
Query: 1869 PCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFTYALEDTPFLRGIIPSR--- 1925
CQ+ IN + C+ P G + P F + L+ R + S
Sbjct: 1068 TCQV--INDTAMLCKAPGIFLGRPQPR----AQGEHPDEFGFLLDHVQTARSLNRSSFTY 1121
Query: 1926 ---------GP-------PGTEIEITGSNF-----GFEILEISVMINNIQCNVTMANDSV 1964
GP PG+ + + G N G L +V+I C++T+++ +
Sbjct: 1122 YPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQL 1181
Query: 1965 V 1965
+
Sbjct: 1182 L 1182
Score = 34.3 bits (77), Expect = 2.7
Identities = 71/321 (22%), Positives = 127/321 (39%), Gaps = 43/321 (13%)
Query: 1559 EVSSCFSPSISNITPSTGTVN--ELITIIGHGFSNLPWANKVTIG--SYPCVVEESSEDS 1614
+V S +P+ ++PS G + +TI G S+L ++VT+ C +
Sbjct: 928 QVYSFVTPTFDQVSPSRGPASGGTRLTISG---SSLDAGSRVTVTVRDSECQFVRRDAKA 984
Query: 1615 ITCHIDPQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGM 1674
I C I P +++ + +TL + N S + P + + P G
Sbjct: 985 IVC-ISPLSTLGPS-QAPITLAI----DRANISSPGLIYTYTQDPTVTRLEPTWSIINGS 1038
Query: 1675 TSVTIKGSGFAVSS-----AGVKVLMGHFPCKVLSVNYTAIECET--------SPAAQQL 1721
T++T+ G+ A + + C+V +N TA+ C+ P AQ
Sbjct: 1039 TAITVSGTHLLTVQEPRVRAKYRGIETTNTCQV--INDTAMLCKAPGIFLGRPQPRAQGE 1096
Query: 1722 VDVD---LLIHGVPAQCQGNCTFSYLESITPYITGVFPNSVIG---SVKVLIEGEGL--- 1772
+ LL H A+ +F+Y P + P+ V+ V+++G+ L
Sbjct: 1097 HPDEFGFLLDHVQTARSLNRSSFTYYPD--PSFEPLGPSGVLDVKPGSHVVLKGKNLIPA 1154
Query: 1773 --GTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNLTVSS 1830
G+ + V IG Q ++ V++ + +P G V V+VG LG L +S+
Sbjct: 1155 AAGSSRLNYTVLIGGQPC-SLTVSDTQLLC-DSPSQTGRQPVMVLVGGLEFWLGTLHISA 1212
Query: 1831 PPVASLSPTSGSIGGGTTLVI 1851
+L G GG L++
Sbjct: 1213 ERALTLPAMMGLAAGGGLLLL 1233
Score = 33.9 bits (76), Expect = 3.5
Identities = 24/64 (37%), Positives = 29/64 (45%), Gaps = 5/64 (7%)
Query: 267 QTYAEVTMIF----PSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSIC 322
Q Y+ VT F PS+G GGT LTISG D V V V C + +I
Sbjct: 928 QVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLD-AGSRVTVTVRDSECQFVRRDAKAIV 986
Query: 323 CKTP 326
C +P
Sbjct: 987 CISP 990
>gi|157738645 plexin A4 isoform 1 [Homo sapiens]
Length = 1894
Score = 68.2 bits (165), Expect = 2e-10
Identities = 90/381 (23%), Positives = 149/381 (39%), Gaps = 54/381 (14%)
Query: 1036 PSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYEEGTILTIVGSGFS-- 1093
P+Q+ Q + ++G +KC+ P + I P G E GT +TI G
Sbjct: 839 PAQESQW-LELSGAKSKCTN-----------PRITEIIPVTGPREGGTKVTIRGENLGLE 886
Query: 1094 -PSSAVTVSVGPVGCSLLS---VDEKELKCQILNGS----AGHAPVAVSMADVGLAQNVG 1145
A V V V CS L + +++ C++ AG + V++
Sbjct: 887 FRDIASHVKVAGVECSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVCRPEFMAR-- 944
Query: 1146 GEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFNENSKVLV--GNETCNVIEGDLNRI 1203
+ Y+ +S + P G ++GGT +T++G N S V+V G + C + I
Sbjct: 945 SSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYI 1004
Query: 1204 TCRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGY 1263
C T E +++ V+ +A + ++ P I P+ + G + + G
Sbjct: 1005 VCNTTSSDE-VLEMKVSVQVDRAKIHQDLVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGT 1063
Query: 1264 NFGNELTQNMAVYV--GGKT----CQILHWNFTDIRCLLPKLSPGK-HDIYVEVRNWGFA 1316
+ +L QN + GGK C++L N T++ C P L+ G H + R F
Sbjct: 1064 HL--DLIQNPQIRAKHGGKEHINICEVL--NATEMTCQAPALALGPDHQSDLTERPEEFG 1119
Query: 1317 STRDKLNSSI--------QYVLEVTSMFPQRG--SLFGGTEITIRGFGF------STIPA 1360
D + S + Y V F G L GT I ++G +
Sbjct: 1120 FILDNVQSLLILNKTNFTYYPNPVFEAFGPSGILELKPGTPIILKGKNLIPPVAGGNVKL 1179
Query: 1361 ENTVLLGSIPCNVTSSSENVI 1381
TVL+G PC VT S ++
Sbjct: 1180 NYTVLVGEKPCTVTVSDVQLL 1200
Score = 62.4 bits (150), Expect = 9e-09
Identities = 51/213 (23%), Positives = 98/213 (46%), Gaps = 21/213 (9%)
Query: 1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEIS--VMINNIQCNVTMAN---DSVVQCI 1968
P + IIP GP GT++ I G N G E +I+ V + ++C+ + + C
Sbjct: 858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCE 917
Query: 1969 VGD-----HAGGTFPVMMHHKTKGSAMSTVVFEY-PLNIQNINPSQGSFGGGQTMTVTGT 2022
+G+ HAG + + + A S+ ++ + L + ++ PS+G GG +T+TGT
Sbjct: 918 MGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGT 977
Query: 2023 GFNPQNSIILVCGSE-CAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMT 2081
N ++++++ G + C R Y ++C N T +++ E+ V D ++
Sbjct: 978 NLNAGSNVVVMFGKQPCLFHRRSPSY--IVC-----NTTSSDEVLEMKVSVQVDRAKIHQ 1030
Query: 2082 PFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGS 2114
+ P I + P+ +G T + V G+
Sbjct: 1031 DLVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGT 1063
Score = 45.8 bits (107), Expect = 9e-04
Identities = 42/161 (26%), Positives = 67/161 (41%), Gaps = 7/161 (4%)
Query: 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMA-VYVGGKTCQILHWNFT---DIRCL 1295
P IT+ P G +TI+G N G E + V V G C L + I C
Sbjct: 858 PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCE 917
Query: 1296 LPKLSPGKHDIYVEVRNWGFASTRDKLNSSIQYVLEVT--SMFPQRGSLFGGTEITIRGF 1353
+ + P +H +VE+ +S + Y + +T + P RG + GGT++TI G
Sbjct: 918 MGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGT 977
Query: 1354 GFSTIPAENTVLLGSIPCNVTSSSENVIKCILHSTGNIFRI 1394
+ + V+ G PC S + I C S+ + +
Sbjct: 978 NLNA-GSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEM 1017
Score = 45.4 bits (106), Expect = 0.001
Identities = 94/399 (23%), Positives = 151/399 (37%), Gaps = 61/399 (15%)
Query: 1561 SSCFSPSISNITPSTGTVN--ELITIIGH--GFSNLPWANKVTIGSYPC---VVEESSED 1613
S C +P I+ I P TG +TI G G A+ V + C V +
Sbjct: 853 SKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAE 912
Query: 1614 SITCHI-DPQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRR------FVLLPNIDLVLP 1666
I C + + + S G E + EF R F+ L DL P
Sbjct: 913 QIVCEMGEAKPSQHAGFVEI----------CVAVCRPEFMARSSQLYYFMTLTLSDLK-P 961
Query: 1667 NAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDL 1726
+ G +G T VTI G+ S V V+ G PC + + I C T+ ++ +++++ +
Sbjct: 962 SRGPMSGGTQVTITGTNLNAGS-NVVVMFGKQPCLFHRRSPSYIVCNTT-SSDEVLEMKV 1019
Query: 1727 LIHGVPAQCQGNCTFSYLESITPYITGVFP--NSVIGSVKVLIEGEGLGTVLEDI--AVF 1782
+ A+ + F Y+E P I + P + V G+ + + G L + A
Sbjct: 1020 SVQVDRAKIHQDLVFQYVED--PTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKH 1077
Query: 1783 IGNQQFRAIEV-NENNITALVTPLPVG--HHS------------VSVVVGSKGLALGNLT 1827
G + EV N +T L +G H S + V L N T
Sbjct: 1078 GGKEHINICEVLNATEMTCQAPALALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFT 1137
Query: 1828 VSSPPVASLSPTSG--SIGGGTTLVITGNGFYPG--------NTTVTIGDEPCQIISINP 1877
PV SG + GT +++ G P N TV +G++PC ++++
Sbjct: 1138 YYPNPVFEAFGPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPC-TVTVSD 1196
Query: 1878 NEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFTYALEDTP 1916
++ C +P G V V + Y P + Y D+P
Sbjct: 1197 VQLLCESP-NLIGRHKVMARVGGMEYSPGM-VYIAPDSP 1233
Score = 43.5 bits (101), Expect = 0.004
Identities = 51/200 (25%), Positives = 80/200 (40%), Gaps = 23/200 (11%)
Query: 1736 QGNCTFSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNE 1795
+ CT + I P +TG P G KV I GE LG DIA + + +
Sbjct: 852 KSKCTNPRITEIIP-VTG--PRE--GGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVD 906
Query: 1796 NNITALVTPLPVGHHSVSVVVGSKGLALGN-----LTVSSP-------PVASLSPTSGSI 1843
I A +G S G + + + SS ++ L P+ G +
Sbjct: 907 GYIPAEQIVCEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPM 966
Query: 1844 GGGTTLVITGNGFYPG-NTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFV---N 1899
GGT + ITG G N V G +PC +P+ + C T + ++++K+ V
Sbjct: 967 SGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNT-TSSDEVLEMKVSVQVDR 1025
Query: 1900 TIAYPPLLFTYALEDTPFLR 1919
+ L+F Y +ED +R
Sbjct: 1026 AKIHQDLVFQY-VEDPTIVR 1044
Score = 38.5 bits (88), Expect = 0.14
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 19/157 (12%)
Query: 2001 IQNINPSQGSFGGGQTMTVTGTG----FNPQNSIILVCGSECAIDRLRSDYTT---LLCE 2053
I I P G GG +T+ G F S + V G EC+ L Y ++CE
Sbjct: 860 ITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECS--PLVDGYIPAEQIVCE 917
Query: 2054 I----PSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRL 2109
+ PS + G + C V+V + +++S + Y ++LT ++ + P RG +GGT++
Sbjct: 918 MGEAKPSQHA-GFVEIC-VAVCRPEFMARSSQLY-YFMTLT--LSDLKPSRGPMSGGTQV 972
Query: 2110 TVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMT 2146
T+ G+ + +V + + C + ++I+C T
Sbjct: 973 TITGTNLNAG-SNVVVMFGKQPCLFHRRSPSYIVCNT 1008
Score = 37.7 bits (86), Expect = 0.24
Identities = 73/312 (23%), Positives = 118/312 (37%), Gaps = 86/312 (27%)
Query: 31 PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITCDVEK 90
P++TEIIP G G T++TIRGE N G++ ++ + V++ + C
Sbjct: 858 PRITEIIPVTGPREGGTKVTIRGE--------NLGLEFRDIASHVKV----AGVECSPLV 905
Query: 91 DA-SHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKS-----FR 144
D + QI C + V + C+ F A+S F
Sbjct: 906 DGYIPAEQIVCEMGEAKPSQHAGFVEICVA------VCRPE-------FMARSSQLYYFM 952
Query: 145 TPTIRSITPLSG--TPGTLITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLI 202
T T+ + P G + GT +TI G+N+ SN + V G PC L
Sbjct: 953 TLTLSDLKPSRGPMSGGTQVTIT--------GTNLNAGSN------VVVMFGKQPC--LF 996
Query: 203 PQSDNLYGLKLDHPNGDMGSMVCKTTGT-FIGHHNVSFILDNDYGRSFPQKMAYFVSSLN 261
+ Y +VC TT + + VS +D + ++
Sbjct: 997 HRRSPSY-------------IVCNTTSSDEVLEMKVSVQVDR--------------AKIH 1029
Query: 262 KIAMFQTYAEVTM--IFPSQGSIRGGTTLTISGRFFDQTDFP-VRVLVGGEP----CDIL 314
+ +FQ + T+ I P + G T + + G D P +R GG+ C++L
Sbjct: 1030 QDLVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEVL 1089
Query: 315 NVTENSICCKTP 326
N TE + C+ P
Sbjct: 1090 NATE--MTCQAP 1099
>gi|49355818 plexin A1 [Homo sapiens]
Length = 1873
Score = 68.2 bits (165), Expect = 2e-10
Identities = 106/423 (25%), Positives = 161/423 (38%), Gaps = 54/423 (12%)
Query: 1053 CSGDCGFTW------DSNIT-PLVLAISPSQGSYEEGTILTIVGSGFS---PSSAVTVSV 1102
C+ D +W S T P +L +SP G + GT LTI G + V V
Sbjct: 820 CAADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRV 879
Query: 1103 GPVGCSLLS---VDEKELKCQILNGS---AGHAPVAVSMADVGLAQNVGGEEFYFVYQSQ 1156
G V CS + + +++ C+I + S A A V V + D + +
Sbjct: 880 GKVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPT 939
Query: 1157 ISHIWPDSGSIAGGTLLTLSGFGFNENSKVL--VGNETCNVIEGDLNRITCRTPK-KTEG 1213
+ P G ++GGT + + G N S V VG C+ + I C TP ++ G
Sbjct: 940 FYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSVGGRPCSFSWRNSREIRCLTPPGQSPG 999
Query: 1214 TVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYNFGNELTQNM 1273
+ I + N Q T + YN + P I P+ G LT+ G N +
Sbjct: 1000 SAPIIININRAQLTNPEV-KYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRI 1058
Query: 1274 AVYVGG--KTCQILHWNFTDIRCLLPKL-----SPGKHDIYVEVRNWGFASTRDKL---N 1323
GG + L +N T + C P + SP + + + + R L +
Sbjct: 1059 RAKYGGIERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLNS 1118
Query: 1324 SSIQY----VLEVTS------MFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNV 1373
+S Y VLE S + P + G + G S + TVL+GS PC +
Sbjct: 1119 TSFLYYPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRL--NYTVLIGSTPCTL 1176
Query: 1374 TSSSENVIKCILHSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLR 1433
T SE + C +T K +V G+ +SP L V + T P +
Sbjct: 1177 T-VSETQLLC------EAPNLTGQHKVTVRAGGFEFSPGTLQVYSDSLL-----TLPAIV 1224
Query: 1434 GIG 1436
GIG
Sbjct: 1225 GIG 1227
Score = 62.8 bits (151), Expect = 7e-09
Identities = 57/219 (26%), Positives = 95/219 (43%), Gaps = 20/219 (9%)
Query: 1966 QCIVGDHAGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGT--G 2023
+C + H P H GS+ T I ++P G GG +T+TG G
Sbjct: 813 RCSLRHHCAADTPASWMHARHGSSRCT-----DPKILKLSPETGPRQGGTRLTITGENLG 867
Query: 2024 FNPQNSIILVCGSECAIDRLRSDYTT---LLCEIPSNNGTGAEQAC-EVSVVNGKDLSQS 2079
++ + V + + S+Y + ++CEI + A A EV V + ++
Sbjct: 868 LRFEDVRLGVRVGKVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRA 927
Query: 2080 MTP--FTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYS 2137
++P FT+ +TP VSP RG +GGT + + GS + DV +++ C +
Sbjct: 928 LSPKRFTF---VTPTFYRVSPSRGPLSGGTWIGIEGSHLNAG-SDVAVSVGGRPCSFSWR 983
Query: 2138 NKTHIICMTDAHTLSGWAPVCVHIRGVGMAKLDNADFLY 2176
N I C+T G AP+ ++I A+L N + Y
Sbjct: 984 NSREIRCLTPPGQSPGSAPIIINI---NRAQLTNPEVKY 1019
Score = 55.8 bits (133), Expect = 9e-07
Identities = 83/344 (24%), Positives = 130/344 (37%), Gaps = 51/344 (14%)
Query: 1761 GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHS--------V 1812
G ++ I GE LG ED+ + + + V I+A +G S V
Sbjct: 855 GGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVESEYISAEQIVCEIGDASSVRAHDALV 914
Query: 1813 SVVVGS-----KGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYPG-NTTVTIG 1866
V V + L+ T +P +SP+ G + GGT + I G+ G + V++G
Sbjct: 915 EVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSVG 974
Query: 1867 DEPCQIISINPNEVYCRTPAG-TTGMVDVKIFVN--TIAYPPLLFTYALEDTPFLRGIIP 1923
PC N E+ C TP G + G + I +N + P + + Y ED LR I P
Sbjct: 975 GRPCSFSWRNSREIRCLTPPGQSPGSAPIIININRAQLTNPEVKYNYT-EDPTILR-IDP 1032
Query: 1924 --SRGPPGTEIEITGSN------------FGFEILEISVMINNIQCNVTMANDSVVQCIV 1969
S GT + +TG+N +G E ++ N V A SV +
Sbjct: 1033 EWSINSGGTLLTVTGTNLATVREPRIRAKYGGIERENGCLVYNDTTMVCRA-PSVANPVR 1091
Query: 1970 GDHAGGTFP----VMMHHKTKGSAMSTVVFEY----------PLNIQNINPSQGSFGGGQ 2015
G P +M + +++ F Y P + + PS G+
Sbjct: 1092 SPPELGERPDELGFVMDNVRSLLVLNSTSFLYYPDPVLEPLSPTGLLELKPSSPLILKGR 1151
Query: 2016 TMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNNG 2059
+ G + N +L+ + C L T LLCE P+ G
Sbjct: 1152 NLLPPAPGNSRLNYTVLIGSTPCT---LTVSETQLLCEAPNLTG 1192
Score = 54.3 bits (129), Expect = 3e-06
Identities = 64/256 (25%), Positives = 105/256 (41%), Gaps = 27/256 (10%)
Query: 1824 GNLTVSSPPVASLSPTSGSIGGGTTLVITGNG----FYPGNTTVTIGDEPCQIIS---IN 1876
G+ + P + LSP +G GGT L ITG F V +G C + I+
Sbjct: 834 GSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVESEYIS 893
Query: 1877 PNEVYCRTPAGTT-----GMVDVKI---FVNTIAYPPLLFTYALEDTPFLRGIIPSRGP- 1927
++ C ++ +V+V + + A P FT+ TP + PSRGP
Sbjct: 894 AEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFV---TPTFYRVSPSRGPL 950
Query: 1928 -PGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIV-GDHAGGTFPVMMHHKT 1985
GT I I GS+ +++V + C+ + N ++C+ + G+ P++++
Sbjct: 951 SGGTWIGIEGSHLNAG-SDVAVSVGGRPCSFSWRNSREIRCLTPPGQSPGSAPIIININR 1009
Query: 1986 KGSAMSTVVFEYPLN--IQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVC---GSECAI 2040
V + Y + I I+P GG +TVTGT + G E
Sbjct: 1010 AQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGGIEREN 1069
Query: 2041 DRLRSDYTTLLCEIPS 2056
L + TT++C PS
Sbjct: 1070 GCLVYNDTTMVCRAPS 1085
Score = 47.4 bits (111), Expect = 3e-04
Identities = 50/217 (23%), Positives = 86/217 (39%), Gaps = 21/217 (9%)
Query: 1916 PFLRGIIPSRGPP--GTEIEITGSNFG--FEILEISVMINNIQCNVTMA---NDSVVQCI 1968
P + + P GP GT + ITG N G FE + + V + + C+ + + + C
Sbjct: 841 PKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVESEYISAEQIVCE 900
Query: 1969 VGD------HAGGTFPVMMHHKTKGSAMSTVVFEYPL-NIQNINPSQGSFGGGQTMTVTG 2021
+GD H + A+S F + ++PS+G GG + + G
Sbjct: 901 IGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEG 960
Query: 2022 TGFNPQNSI-ILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSM 2080
+ N + + + V G C+ S + C P G+ A + +N L+
Sbjct: 961 SHLNAGSDVAVSVGGRPCSFSWRNS--REIRCLTPPGQSPGS--APIIININRAQLTNPE 1016
Query: 2081 TPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFS 2117
+ Y P I + P+ +GGT LTV G+ +
Sbjct: 1017 VKYNYTED--PTILRIDPEWSINSGGTLLTVTGTNLA 1051
Score = 37.4 bits (85), Expect = 0.32
Identities = 48/172 (27%), Positives = 73/172 (42%), Gaps = 38/172 (22%)
Query: 31 PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGV--DNAELGNSVQLISSFQSITCDV 88
PK+ ++ P+ G G TRLTI GE N G+ ++ LG V + + V
Sbjct: 841 PKILKLSPETGPRQGGTRLTITGE--------NLGLRFEDVRLGVRVGKV-----LCSPV 887
Query: 89 EKDASHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTPTI 148
E + + QI C D+ +VR V V + C H + + +F TPT
Sbjct: 888 ESEYISAEQIVCEI----GDASSVRAHDALVEVCVRD-CSPHYRA--LSPKRFTFVTPTF 940
Query: 149 RSITPLSG--TPGTLITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPC 198
++P G + GT I I+G GS++A+S +GG PC
Sbjct: 941 YRVSPSRGPLSGGTWIGIEGSHLN--AGSDVAVS------------VGGRPC 978
Score = 36.2 bits (82), Expect = 0.71
Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 1/53 (1%)
Query: 275 IFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPP 327
+ PS+G + GGT + I G + V V VGG PC I C TPP
Sbjct: 943 VSPSRGPLSGGTWIGIEGSHLNAGS-DVAVSVGGRPCSFSWRNSREIRCLTPP 994
>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
Length = 1408
Score = 67.4 bits (163), Expect = 3e-10
Identities = 50/155 (32%), Positives = 75/155 (48%), Gaps = 21/155 (13%)
Query: 1157 ISHIWPDSGSIAGGTLLTLSG--FGFNENSK-------VLVGNETCNVI--EGDLNRITC 1205
I ++P+S + GGT LT+ G FGF N+K VL+GNE+C + E +N + C
Sbjct: 565 IYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKC 624
Query: 1206 RTPKKTEGTVDIS-VTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKG-- 1262
++S + +NG T FSY P+IT SPK + G LT+ G
Sbjct: 625 TVGPAMNKHFNMSIIISNGHGTTQYSTFSY---VDPVITSISPKYGPMAGGTLLTLTGNY 681
Query: 1263 YNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLP 1297
N GN + + +GGKTC + + + + C P
Sbjct: 682 LNSGN----SRHISIGGKTCTLKSVSNSILECYTP 712
Score = 63.2 bits (152), Expect = 5e-09
Identities = 66/274 (24%), Positives = 112/274 (40%), Gaps = 34/274 (12%)
Query: 1055 GDCGFTWDSNITPLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVGCSLLSVDE 1114
G ++ S + P++ +ISP G GT+LT+ G+ + ++ +S+G C+L SV
Sbjct: 645 GTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSN 704
Query: 1115 KELKC-----QILNGSAGHAPVAVSMADVGLAQNVGGEEFYFVY--QSQISHIWPDSGSI 1167
L+C I A + ++ + + Y ++ +S IS W + +I
Sbjct: 705 SILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNI 764
Query: 1168 --------AGGTLLTLSGFGFNENSKVLVGNETCNVIEGDLN------------RITCRT 1207
+GG+ T++G G N NS V V NV E N I C T
Sbjct: 765 VSFLFCFASGGS--TITGVGKNLNS-VSVPRMVINVHEAGRNFTVACQHRSNSEIICCTT 821
Query: 1208 PKKTEGTVDISVTTNGF---QATARDAFSYNCLQTPIITDFSPKVRTILGEVN-LTIKGY 1263
P + + + + T F F + P+ F V +G N L IKG
Sbjct: 822 PSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGN 881
Query: 1264 NFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLP 1297
+ E + + VG K+C+ +H + + C +P
Sbjct: 882 DIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVP 915
Score = 60.1 bits (144), Expect = 5e-08
Identities = 65/254 (25%), Positives = 110/254 (43%), Gaps = 21/254 (8%)
Query: 1749 PYITGVFPNS--VIGSVKVLIEGEGLGTV------LEDIAVFIGNQQ--FRAIEVNENNI 1798
P I VFPNS + G ++ I G G L+ V +GN+ E N +
Sbjct: 563 PAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTL 622
Query: 1799 TALVTPLPVGHHSVSVVV--GSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGF 1856
V P H ++S+++ G + P + S+SP G + GGT L +TGN
Sbjct: 623 KCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYL 682
Query: 1857 YPGNTT-VTIGDEPCQIISINPNEVYCRTPAGTTGM-VDVKIFVNTIAYPPLLFTYALED 1914
GN+ ++IG + C + S++ + + C TPA T VK+ ++ +F+Y +
Sbjct: 683 NSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSY--RE 740
Query: 1915 TPFLRGIIPSRGPPGT--EIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDH 1972
P + I P++ T + + +F F I + N+ SV + ++ H
Sbjct: 741 DPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITGVGKNLNSV--SVPRMVINVH 798
Query: 1973 -AGGTFPVMMHHKT 1985
AG F V H++
Sbjct: 799 EAGRNFTVACQHRS 812
Score = 58.5 bits (140), Expect = 1e-07
Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 19/162 (11%)
Query: 2001 IQNINPSQGSFGGGQTMTVTGT--GFNPQNSI------ILVCGSECAIDRLRSDYTTLLC 2052
I + P+ GG +T+ G GF N +L+ C + S TL C
Sbjct: 565 IYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKC 624
Query: 2053 EIPSNNGTGAEQACEVSVV--NGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLT 2110
+ G + +S++ NG +Q T F+Y + P+IT++SPK G AGGT LT
Sbjct: 625 TV----GPAMNKHFNMSIIISNGHGTTQYST-FSY---VDPVITSISPKYGPMAGGTLLT 676
Query: 2111 VVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLS 2152
+ G+ + + HI+I C ++ + + + C T A T+S
Sbjct: 677 LTGN-YLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTIS 717
Score = 47.8 bits (112), Expect = 2e-04
Identities = 43/175 (24%), Positives = 72/175 (41%), Gaps = 37/175 (21%)
Query: 153 PLSGTPGTLITIQGRIFTDVYGSNIALSSNGK-NVRILRVYIGGMPCELLIPQSDNLYGL 211
PL G GT +TI G F N K +++ RV +G C L + +S
Sbjct: 574 PLEG--GTRLTICGWDF--------GFRRNNKFDLKKTRVLLGNESCTLTLSEST----- 618
Query: 212 KLDHPNGDMGSMVCKTTGTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLNKIAMFQTYAE 271
M ++ C H N+S I+ N +G + +Y
Sbjct: 619 --------MNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSY------------VDPV 658
Query: 272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTP 326
+T I P G + GGT LT++G + + + + +GG+ C + +V+ + + C TP
Sbjct: 659 ITSISPKYGPMAGGTLLTLTGNYLNSGN-SRHISIGGKTCTLKSVSNSILECYTP 712
Score = 39.7 bits (91), Expect = 0.064
Identities = 41/173 (23%), Positives = 66/173 (38%), Gaps = 29/173 (16%)
Query: 30 IPKVTEIIPKYGSINGATRLTIRG--EGFSQANQFNYGVDNAELGNSVQLISSFQSITCD 87
+P + ++ P + G TRLTI G GF + N+F+ LGN +C
Sbjct: 562 LPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNE----------SCT 611
Query: 88 VEKDASHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTPT 147
+ S + C + + + + GH + TF S+ P
Sbjct: 612 LTLSESTMNTLKCTVGPAMNKHFNMSIIIS----------NGHGTTQYSTF---SYVDPV 658
Query: 148 IRSITPLSG--TPGTLITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPC 198
I SI+P G GTL+T+ G G++ +S GK + V + C
Sbjct: 659 ITSISPKYGPMAGGTLLTLTGNYLNS--GNSRHISIGGKTCTLKSVSNSILEC 709
Score = 37.7 bits (86), Expect = 0.24
Identities = 34/151 (22%), Positives = 65/151 (43%), Gaps = 11/151 (7%)
Query: 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQNM-----AVYVGGKTCQILHWNFT--DI 1292
P I P + G LTI G++FG V +G ++C + T +
Sbjct: 563 PAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTL 622
Query: 1293 RCLLPKLSPGKHDIYVEVRNWGFASTRDKLNSSIQYVLEVTSMFPQRGSLFGGTEITIRG 1352
+C + ++ + + N G +T+ S + V +TS+ P+ G + GGT +T+ G
Sbjct: 623 KCTVGPAMNKHFNMSIIISN-GHGTTQYSTFSYVDPV--ITSISPKYGPMAGGTLLTLTG 679
Query: 1353 FGFSTIPAENTVLLGSIPCNVTSSSENVIKC 1383
+ + +G C + S S ++++C
Sbjct: 680 -NYLNSGNSRHISIGGKTCTLKSVSNSILEC 709
Score = 34.7 bits (78), Expect = 2.1
Identities = 29/95 (30%), Positives = 47/95 (49%), Gaps = 12/95 (12%)
Query: 1332 VTSMFPQRGSLFGGTEITIRG--FGF---STIPAENT-VLLGSIPCNVT--SSSENVIKC 1383
+ +FP L GGT +TI G FGF + + T VLLG+ C +T S+ N +KC
Sbjct: 565 IYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKC 624
Query: 1384 ----ILHSTGNIFRITNNGKDSVHGLGYAWSPPVL 1414
++ N+ I +NG + +++ PV+
Sbjct: 625 TVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVI 659
Score = 33.1 bits (74), Expect = 6.0
Identities = 30/92 (32%), Positives = 42/92 (45%), Gaps = 18/92 (19%)
Query: 27 SQIIPKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITC 86
S + P +T I PKYG + G T LT+ G NY GNS + S TC
Sbjct: 653 SYVDPVITSISPKYGPMAGGTLLTLTG---------NY----LNSGNSRHI--SIGGKTC 697
Query: 87 DVEKDASHSTQITCYTRAMP-EDSYTVRVSVD 117
+ K S+S + CYT A + V++ +D
Sbjct: 698 TL-KSVSNSI-LECYTPAQTISTEFAVKLKID 727
>gi|157694524 plexin D1 [Homo sapiens]
Length = 1925
Score = 65.9 bits (159), Expect = 8e-10
Identities = 69/261 (26%), Positives = 113/261 (43%), Gaps = 21/261 (8%)
Query: 1916 PFLRGIIPSRGP--PGTEIEITGSNFGFEILEIS--VMINNIQCNVTMANDSV---VQCI 1968
P +R I P GP GT + I G N G + +++ V I + C +V + C+
Sbjct: 891 PEIRAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCV 950
Query: 1969 VGDHAGGTFPVMMHHKTK-GSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFNPQ 2027
G G V+ + +K G + + PL + ++ P+ G GG +T+ G +
Sbjct: 951 TGPAPGPLSGVVTVNASKEGKSRDRFSYVLPL-VHSLEPTMGPKAGGTRITIHGNDLHVG 1009
Query: 2028 NSI-ILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPFTYA 2086
+ + +LV ++ + +R+D T++ C +P GA A V + T+
Sbjct: 1010 SELQVLVNDTDPCTELMRTD-TSIACTMPE----GALPAPVPVCVRFERRGCVHGNLTFW 1064
Query: 2087 VSLTPLITAVSPKRGSTAGGTRLTVVGSGF----SENMEDVHITIAEAKCDVEYSNKTHI 2142
P+ITA+SP+R +GG +TV G F + +M HI C V N T I
Sbjct: 1065 YMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKV--LNSTLI 1122
Query: 2143 ICMTDAHTLSGWAPVCVHIRG 2163
C + + APV I G
Sbjct: 1123 TCPSPGALSNASAPVDFFING 1143
Score = 53.1 bits (126), Expect = 6e-06
Identities = 63/247 (25%), Positives = 94/247 (38%), Gaps = 24/247 (9%)
Query: 1737 GNCTFSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIA--VFIGNQQFRAIEVN 1794
G C + +I P + G + I G LG L D+A V+IG +
Sbjct: 886 GTCPAPEIRAIEP-----LSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDR 940
Query: 1795 ---ENNITALVTPLPVGHHSVSVVVGSK-GLALGNLTVSSPPVASLSPTSGSIGGGTTLV 1850
I + P P V V SK G + + P V SL PT G GGT +
Sbjct: 941 YTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSRDRFSYVLPLVHSLEPTMGPKAGGTRIT 1000
Query: 1851 ITGNGFYPGN-TTVTIGD-EPCQIISINPNEVYCRTPAGTTGM---VDVKIFVNTIAYPP 1905
I GN + G+ V + D +PC + + C P G V V+ +
Sbjct: 1001 IHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGN 1060
Query: 1906 LLFTYALEDTPFLRGIIPSRGP--PGTEIEITGSNFGFEILEISVMINNIQCNVTMA--- 1960
L F Y P + I P R P G I + G F + +S+ +++I T+
Sbjct: 1061 LTFWYM--QNPVITAISPRRSPVSGGRTITVAGERFHM-VQNVSMAVHHIGREPTLCKVL 1117
Query: 1961 NDSVVQC 1967
N +++ C
Sbjct: 1118 NSTLITC 1124
Score = 52.8 bits (125), Expect = 7e-06
Identities = 65/245 (26%), Positives = 97/245 (39%), Gaps = 22/245 (8%)
Query: 1067 PLVLAISPSQGSYEEGTILTIVGSGFS---PSSAVTVSVGPVGCSLLS---VDEKELKCQ 1120
P + AI P G + GT+LTI G A V +G V C L +E+ C
Sbjct: 891 PEIRAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCV 950
Query: 1121 ILNGSAGHAPVAVSMADVGLAQNVGGEEFYFVYQSQISH-IWPDSGSIAGGTLLTLSGFG 1179
G AP +S A G F Y + H + P G AGGT +T+ G
Sbjct: 951 -----TGPAPGPLSGVVTVNASKEGKSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHGND 1005
Query: 1180 FNENSKVLV---GNETCNVIEGDLNRITCRTPKKT-EGTVDISVTTNGFQATARDAFSYN 1235
+ S++ V + C + I C P+ V + V + ++
Sbjct: 1006 LHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFER-RGCVHGNLTFW 1064
Query: 1236 CLQTPIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGGK---TCQILHWNFTDI 1292
+Q P+IT SP+ + G +T+ G F +MAV+ G+ C++L N T I
Sbjct: 1065 YMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVL--NSTLI 1122
Query: 1293 RCLLP 1297
C P
Sbjct: 1123 TCPSP 1127
Score = 46.2 bits (108), Expect = 7e-04
Identities = 54/219 (24%), Positives = 86/219 (39%), Gaps = 29/219 (13%)
Query: 1156 QISHIWPDSGSIAGGTLLTLSGFGFNENSK-----VLVGNETCN------VIEGDLNRIT 1204
+I I P SG + GGTLLT+ G V +G C + ++ +T
Sbjct: 892 EIRAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVT 951
Query: 1205 CRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYN 1264
P G V ++ + G +RD FSY P++ P + G +TI G +
Sbjct: 952 GPAPGPLSGVVTVNASKEG---KSRDRFSY---VLPLVHSLEPTMGPKAGGTRITIHGND 1005
Query: 1265 F--GNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLS-PGKHDIYVEVRNWGFASTRDK 1321
G+EL + C L T I C +P+ + P + V G
Sbjct: 1006 LHVGSEL---QVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHG--- 1059
Query: 1322 LNSSIQYVLE--VTSMFPQRGSLFGGTEITIRGFGFSTI 1358
N + Y+ +T++ P+R + GG IT+ G F +
Sbjct: 1060 -NLTFWYMQNPVITAISPRRSPVSGGRTITVAGERFHMV 1097
Score = 45.1 bits (105), Expect = 0.002
Identities = 42/155 (27%), Positives = 67/155 (43%), Gaps = 13/155 (8%)
Query: 1063 SNITPLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVG-CSLLSVDEKELKCQI 1121
S + PLV ++ P+ G GT +TI G+ S + V V C+ L + + C +
Sbjct: 977 SYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTM 1036
Query: 1122 LNGS-AGHAPVAVSMADVGLAQNVGGEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGF 1180
G+ PV V G G F+++ I+ I P ++GG +T++G F
Sbjct: 1037 PEGALPAPVPVCVRFERRGCVH--GNLTFWYMQNPVITAISPRRSPVSGGRTITVAGERF 1094
Query: 1181 NENSKVL-----VGNE--TCNVIEGDLNRITCRTP 1208
+ V +G E C V+ L ITC +P
Sbjct: 1095 HMVQNVSMAVHHIGREPTLCKVLNSTL--ITCPSP 1127
Score = 44.7 bits (104), Expect = 0.002
Identities = 58/219 (26%), Positives = 87/219 (39%), Gaps = 23/219 (10%)
Query: 1562 SCFSPSISNITPSTGTVN--ELITIIGHGFSNL--PWANKVTIGSYPCVV---EESSEDS 1614
+C +P I I P +G ++ L+TI G A+ V IG C + +
Sbjct: 887 TCPAPEIRAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEE 946
Query: 1615 ITCHIDPQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNAGSTTGM 1674
I C P G+ VT+ G + DR +LP + + P G G
Sbjct: 947 IVCVTGPAPGPLSGV---VTVNASKEGKSR-------DRFSYVLPLVHSLEPTMGPKAGG 996
Query: 1675 TSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVPAQ 1734
T +TI G+ V S ++ PC L T+I C T P V + +
Sbjct: 997 TRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIAC-TMPEGALPAPVPVCVRFERRG 1055
Query: 1735 C-QGNCTFSYLESITPYITGVFP--NSVIGSVKVLIEGE 1770
C GN TF Y+++ P IT + P + V G + + GE
Sbjct: 1056 CVHGNLTFWYMQN--PVITAISPRRSPVSGGRTITVAGE 1092
Score = 34.3 bits (77), Expect = 2.7
Identities = 25/70 (35%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 271 EVTMIFPSQGSIRGGTTLTISGRFFDQ--TDFPVRVLVGGEPCDIL---NVTENSICCKT 325
E+ I P G + GGT LTI GR + +D V +GG C+ L I C T
Sbjct: 892 EIRAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVT 951
Query: 326 PPKPHILKTV 335
P P L V
Sbjct: 952 GPAPGPLSGV 961
>gi|194272180 plexin B1 [Homo sapiens]
Length = 2135
Score = 63.2 bits (152), Expect = 5e-09
Identities = 70/272 (25%), Positives = 113/272 (41%), Gaps = 21/272 (7%)
Query: 1030 GDLLRTPSQQPQVE-VYVNGIPAKC-----SGDCGFTWDSNITPLVLAISPSQGSYEEGT 1083
GD R + PQ V+ G +C G+ PL+ ++ P G + GT
Sbjct: 1027 GDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVDGGT 1086
Query: 1084 ILTIVGSGFSPSSAVTVSVGPVGCSLLSVDEKELKCQ----ILNGSAGHAPVAVSMADVG 1139
+TI GS + + V +VD +E + + G++G + +V
Sbjct: 1087 RVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVP 1146
Query: 1140 LAQNVGGEEFYFVYQSQISH-IWPDSGSIAGGTLLTLSG----FGFNENSKVLVGNETCN 1194
+ G E F YQ H I+P G AGGT LTL+G G E+ +V+VG++ C+
Sbjct: 1147 -GRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCH 1205
Query: 1195 VI-EGDLNRITCRT-PKKTEGTVDISVTTNGFQ-ATARDAFSYNCLQTPIITDFSPKVRT 1251
++ E ++ C T P+ T T+ ++V + R F Y P IT P
Sbjct: 1206 LLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTL--DPNITSAGPTKSF 1263
Query: 1252 ILGEVNLTIKGYNFGNELTQNMAVYVGGKTCQ 1283
+ G + ++G N T + V V + Q
Sbjct: 1264 LSGGREICVRGQNLDVVQTPRIRVTVVSRMLQ 1295
Score = 56.6 bits (135), Expect = 5e-07
Identities = 48/182 (26%), Positives = 73/182 (40%), Gaps = 11/182 (6%)
Query: 2001 IQNINPSQGSFGGGQTMTVTGTGFNPQNSIIL----VCGSECAIDRLRSDYTTLLCEIPS 2056
I ++ P G GG +T+ G+ +L V G CA+D + ++ L I
Sbjct: 1072 IHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITG 1131
Query: 2057 NNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSG- 2115
+G A V V G+ S F Y P + ++ P RG AGGTRLT+ GS
Sbjct: 1132 ASGEEVAGATAVEVP-GRGRGVSEHDFAYQ---DPKVHSIFPARGPRAGGTRLTLNGSKL 1187
Query: 2116 FSENMEDVHITIAEAKCD-VEYSNKTHIICMTDAHTLSGWAPVCVHIRGVGMAKLDNADF 2174
+ +ED+ + + + C + + C T PV V G +L F
Sbjct: 1188 LTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWF-GATERRLQRGQF 1246
Query: 2175 LY 2176
Y
Sbjct: 1247 KY 1248
Score = 51.2 bits (121), Expect = 2e-05
Identities = 53/210 (25%), Positives = 88/210 (41%), Gaps = 21/210 (10%)
Query: 1157 ISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNET-----CNV------IEGDLNRITC 1205
I + P +G + GGT +T+ G ++ + ++G T C V + L IT
Sbjct: 1072 IHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITG 1131
Query: 1206 RTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYNF 1265
+ ++ G + V G + D F+Y Q P + P G LT+ G
Sbjct: 1132 ASGEEVAGATAVEVPGRGRGVSEHD-FAY---QDPKVHSIFPARGPRAGGTRLTLNGSKL 1187
Query: 1266 GNELTQNMAVYVGGKTCQILHWNFTD-IRCLLPKLSPGKHDIYVEVRNWGFASTRDKLNS 1324
+++ V VG + C +L ++ +RC + SP + V W A+ R
Sbjct: 1188 LTGRLEDIRVVVGDQPCHLLPEQQSEQLRC---ETSPRPTPATLPVAVWFGATERRLQRG 1244
Query: 1325 SIQYVLE--VTSMFPQRGSLFGGTEITIRG 1352
+Y L+ +TS P + L GG EI +RG
Sbjct: 1245 QFKYTLDPNITSAGPTKSFLSGGREICVRG 1274
Score = 49.3 bits (116), Expect = 8e-05
Identities = 34/95 (35%), Positives = 52/95 (54%), Gaps = 10/95 (10%)
Query: 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDV--HITIAEAKCDV---EYSNKTHIICM 2145
PLI +V P G GGTR+T+ GS ++++DV +T+A C V EY + ++C+
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCI 1129
Query: 2146 TDA--HTLSGWAPVCVHIRGVGMAKLDNADFLYVD 2178
T A ++G V V RG G+++ DF Y D
Sbjct: 1130 TGASGEEVAGATAVEVPGRGRGVSE---HDFAYQD 1161
Score = 46.2 bits (108), Expect = 7e-04
Identities = 51/215 (23%), Positives = 86/215 (40%), Gaps = 20/215 (9%)
Query: 1739 CTFSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFR-AIEVNENN 1797
C + S+ P +TG V G +V I G LG ++D+ + A++ E
Sbjct: 1067 CPAPLIHSVEP-LTG----PVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYE 1121
Query: 1798 ITALVTPLP-------VGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLV 1850
+++ + + G +V V +G++ + P V S+ P G GGT L
Sbjct: 1122 VSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLT 1181
Query: 1851 ITGNGFYPG---NTTVTIGDEPCQIISINPNE-VYCRT-PAGTTGMVDVKIFVNTI--AY 1903
+ G+ G + V +GD+PC ++ +E + C T P T + V ++
Sbjct: 1182 LNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRL 1241
Query: 1904 PPLLFTYALEDTPFLRGIIPSRGPPGTEIEITGSN 1938
F Y L+ G S G EI + G N
Sbjct: 1242 QRGQFKYTLDPNITSAGPTKSFLSGGREICVRGQN 1276
Score = 44.3 bits (103), Expect = 0.003
Identities = 85/367 (23%), Positives = 137/367 (37%), Gaps = 77/367 (20%)
Query: 1659 PNIDLVLPNAGSTTGMTSVTIKGS--GFAVSSAGVKVLMGHFPCKVLSVNY---TAIECE 1713
P I V P G G T VTI+GS G V V + PC V + Y +++ C
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCI 1129
Query: 1714 TSPAAQQLVDVDLLIHGVPAQCQG--NCTFSYLESITPYITGVFP--NSVIGSVKVLIEG 1769
T + +++ + VP + +G F+Y + P + +FP G ++ + G
Sbjct: 1130 TGASGEEVAGATAV--EVPGRGRGVSEHDFAYQD---PKVHSIFPARGPRAGGTRLTLNG 1184
Query: 1770 EGLGT-VLEDIAVFIGNQQFRAI-EVNENNITALVTPLPV-GHHSVSVVVGS--KGLALG 1824
L T LEDI V +G+Q + E + +P P V+V G+ + L G
Sbjct: 1185 SKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRG 1244
Query: 1825 NLTVS-SPPVASLSPTSGSIGGGTTLVITGNGF--------------------------- 1856
+ P + S PT + GG + + G
Sbjct: 1245 QFKYTLDPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRR 1304
Query: 1857 -YPGNTTVTIG--------DEPCQIISINPNEVYCRTPA----GTTGMVDVKIFVNTIAY 1903
T ++G +EPC + S + CRTPA V V+ ++ + +
Sbjct: 1305 RVVPETACSLGPSCSSQQFEEPCHVNS--SQLITCRTPALPGLPEDPWVRVEFILDNLVF 1362
Query: 1904 P-----PLLFTYALEDTPFLRGI------IPSRGPPGTEIEITGSNFGFEIL--EISVMI 1950
P F+Y E P L+ + +P R PG+ + G N + E+ MI
Sbjct: 1363 DFATLNPTPFSY--EADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMI 1420
Query: 1951 NNIQCNV 1957
+ C V
Sbjct: 1421 GDGPCVV 1427
Score = 42.4 bits (98), Expect = 0.010
Identities = 47/190 (24%), Positives = 80/190 (42%), Gaps = 42/190 (22%)
Query: 146 PTIRSITPLSGTP--GTLITIQGRIFTDVYGSNIALSSNGKNVRIL--RVYIGGMPCELL 201
P I S+ PL+G GT +TI+G S+ G++V+ + V + G+PC
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRG-------------SNLGQHVQDVLGMVTVAGVPCA-- 1114
Query: 202 IPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLN 261
+ + L G G V T + + ++D+ P+
Sbjct: 1115 VDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRG-VSEHDFAYQDPK---------- 1163
Query: 262 KIAMFQTYAEVTMIFPSQGSIRGGTTLTISG-RFFDQTDFPVRVLVGGEPCDILNVTEN- 319
V IFP++G GGT LT++G + +RV+VG +PC +L ++
Sbjct: 1164 ----------VHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSE 1213
Query: 320 SICCKTPPKP 329
+ C+T P+P
Sbjct: 1214 QLRCETSPRP 1223
Score = 40.4 bits (93), Expect = 0.038
Identities = 49/210 (23%), Positives = 83/210 (39%), Gaps = 17/210 (8%)
Query: 1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEI--SVMINNIQCNVTMANDSVVQCIV-- 1969
P + + P GP GT + I GSN G + ++ V + + C V V +V
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCI 1129
Query: 1970 ----GDHAGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGF- 2024
G+ G V + + +G + ++ P + +I P++G GG +T+ G+
Sbjct: 1130 TGASGEEVAGATAVEVPGRGRGVSEHDFAYQDP-KVHSIFPARGPRAGGTRLTLNGSKLL 1188
Query: 2025 -NPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPF 2083
I +V G + L CE S T A V+V G + +
Sbjct: 1189 TGRLEDIRVVVGDQPCHLLPEQQSEQLRCE-TSPRPTPA--TLPVAVWFGA-TERRLQRG 1244
Query: 2084 TYAVSLTPLITAVSPKRGSTAGGTRLTVVG 2113
+ +L P IT+ P + +GG + V G
Sbjct: 1245 QFKYTLDPNITSAGPTKSFLSGGREICVRG 1274
Score = 37.4 bits (85), Expect = 0.32
Identities = 43/181 (23%), Positives = 72/181 (39%), Gaps = 47/181 (25%)
Query: 31 PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITCDVE- 89
P + + P G ++G TR+TIRG Q Q G + + + C V+
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLG------------MVTVAGVPCAVDA 1117
Query: 90 KDASHSTQITCYTRAMPED---SYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTP 146
++ S+ + C T A E+ + V V G V+E++ +++ P
Sbjct: 1118 QEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDF---------------AYQDP 1162
Query: 147 TIRSITPLSG--TPGTLITIQG-RIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLIP 203
+ SI P G GT +T+ G ++ T + +RV +G PC LL
Sbjct: 1163 KVHSIFPARGPRAGGTRLTLNGSKLLTG-------------RLEDIRVVVGDQPCHLLPE 1209
Query: 204 Q 204
Q
Sbjct: 1210 Q 1210
>gi|40254442 plexin B1 [Homo sapiens]
Length = 2135
Score = 63.2 bits (152), Expect = 5e-09
Identities = 70/272 (25%), Positives = 113/272 (41%), Gaps = 21/272 (7%)
Query: 1030 GDLLRTPSQQPQVE-VYVNGIPAKC-----SGDCGFTWDSNITPLVLAISPSQGSYEEGT 1083
GD R + PQ V+ G +C G+ PL+ ++ P G + GT
Sbjct: 1027 GDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVDGGT 1086
Query: 1084 ILTIVGSGFSPSSAVTVSVGPVGCSLLSVDEKELKCQ----ILNGSAGHAPVAVSMADVG 1139
+TI GS + + V +VD +E + + G++G + +V
Sbjct: 1087 RVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVP 1146
Query: 1140 LAQNVGGEEFYFVYQSQISH-IWPDSGSIAGGTLLTLSG----FGFNENSKVLVGNETCN 1194
+ G E F YQ H I+P G AGGT LTL+G G E+ +V+VG++ C+
Sbjct: 1147 -GRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCH 1205
Query: 1195 VI-EGDLNRITCRT-PKKTEGTVDISVTTNGFQ-ATARDAFSYNCLQTPIITDFSPKVRT 1251
++ E ++ C T P+ T T+ ++V + R F Y P IT P
Sbjct: 1206 LLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTL--DPNITSAGPTKSF 1263
Query: 1252 ILGEVNLTIKGYNFGNELTQNMAVYVGGKTCQ 1283
+ G + ++G N T + V V + Q
Sbjct: 1264 LSGGREICVRGQNLDVVQTPRIRVTVVSRMLQ 1295
Score = 56.6 bits (135), Expect = 5e-07
Identities = 48/182 (26%), Positives = 73/182 (40%), Gaps = 11/182 (6%)
Query: 2001 IQNINPSQGSFGGGQTMTVTGTGFNPQNSIIL----VCGSECAIDRLRSDYTTLLCEIPS 2056
I ++ P G GG +T+ G+ +L V G CA+D + ++ L I
Sbjct: 1072 IHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITG 1131
Query: 2057 NNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSG- 2115
+G A V V G+ S F Y P + ++ P RG AGGTRLT+ GS
Sbjct: 1132 ASGEEVAGATAVEVP-GRGRGVSEHDFAYQ---DPKVHSIFPARGPRAGGTRLTLNGSKL 1187
Query: 2116 FSENMEDVHITIAEAKCD-VEYSNKTHIICMTDAHTLSGWAPVCVHIRGVGMAKLDNADF 2174
+ +ED+ + + + C + + C T PV V G +L F
Sbjct: 1188 LTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWF-GATERRLQRGQF 1246
Query: 2175 LY 2176
Y
Sbjct: 1247 KY 1248
Score = 51.2 bits (121), Expect = 2e-05
Identities = 53/210 (25%), Positives = 88/210 (41%), Gaps = 21/210 (10%)
Query: 1157 ISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNET-----CNV------IEGDLNRITC 1205
I + P +G + GGT +T+ G ++ + ++G T C V + L IT
Sbjct: 1072 IHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITG 1131
Query: 1206 RTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYNF 1265
+ ++ G + V G + D F+Y Q P + P G LT+ G
Sbjct: 1132 ASGEEVAGATAVEVPGRGRGVSEHD-FAY---QDPKVHSIFPARGPRAGGTRLTLNGSKL 1187
Query: 1266 GNELTQNMAVYVGGKTCQILHWNFTD-IRCLLPKLSPGKHDIYVEVRNWGFASTRDKLNS 1324
+++ V VG + C +L ++ +RC + SP + V W A+ R
Sbjct: 1188 LTGRLEDIRVVVGDQPCHLLPEQQSEQLRC---ETSPRPTPATLPVAVWFGATERRLQRG 1244
Query: 1325 SIQYVLE--VTSMFPQRGSLFGGTEITIRG 1352
+Y L+ +TS P + L GG EI +RG
Sbjct: 1245 QFKYTLDPNITSAGPTKSFLSGGREICVRG 1274
Score = 49.3 bits (116), Expect = 8e-05
Identities = 34/95 (35%), Positives = 52/95 (54%), Gaps = 10/95 (10%)
Query: 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDV--HITIAEAKCDV---EYSNKTHIICM 2145
PLI +V P G GGTR+T+ GS ++++DV +T+A C V EY + ++C+
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCI 1129
Query: 2146 TDA--HTLSGWAPVCVHIRGVGMAKLDNADFLYVD 2178
T A ++G V V RG G+++ DF Y D
Sbjct: 1130 TGASGEEVAGATAVEVPGRGRGVSE---HDFAYQD 1161
Score = 46.2 bits (108), Expect = 7e-04
Identities = 51/215 (23%), Positives = 86/215 (40%), Gaps = 20/215 (9%)
Query: 1739 CTFSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFR-AIEVNENN 1797
C + S+ P +TG V G +V I G LG ++D+ + A++ E
Sbjct: 1067 CPAPLIHSVEP-LTG----PVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYE 1121
Query: 1798 ITALVTPLP-------VGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLV 1850
+++ + + G +V V +G++ + P V S+ P G GGT L
Sbjct: 1122 VSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLT 1181
Query: 1851 ITGNGFYPG---NTTVTIGDEPCQIISINPNE-VYCRT-PAGTTGMVDVKIFVNTI--AY 1903
+ G+ G + V +GD+PC ++ +E + C T P T + V ++
Sbjct: 1182 LNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRL 1241
Query: 1904 PPLLFTYALEDTPFLRGIIPSRGPPGTEIEITGSN 1938
F Y L+ G S G EI + G N
Sbjct: 1242 QRGQFKYTLDPNITSAGPTKSFLSGGREICVRGQN 1276
Score = 44.3 bits (103), Expect = 0.003
Identities = 85/367 (23%), Positives = 137/367 (37%), Gaps = 77/367 (20%)
Query: 1659 PNIDLVLPNAGSTTGMTSVTIKGS--GFAVSSAGVKVLMGHFPCKVLSVNY---TAIECE 1713
P I V P G G T VTI+GS G V V + PC V + Y +++ C
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCI 1129
Query: 1714 TSPAAQQLVDVDLLIHGVPAQCQG--NCTFSYLESITPYITGVFP--NSVIGSVKVLIEG 1769
T + +++ + VP + +G F+Y + P + +FP G ++ + G
Sbjct: 1130 TGASGEEVAGATAV--EVPGRGRGVSEHDFAYQD---PKVHSIFPARGPRAGGTRLTLNG 1184
Query: 1770 EGLGT-VLEDIAVFIGNQQFRAI-EVNENNITALVTPLPV-GHHSVSVVVGS--KGLALG 1824
L T LEDI V +G+Q + E + +P P V+V G+ + L G
Sbjct: 1185 SKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRG 1244
Query: 1825 NLTVS-SPPVASLSPTSGSIGGGTTLVITGNGF--------------------------- 1856
+ P + S PT + GG + + G
Sbjct: 1245 QFKYTLDPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRR 1304
Query: 1857 -YPGNTTVTIG--------DEPCQIISINPNEVYCRTPA----GTTGMVDVKIFVNTIAY 1903
T ++G +EPC + S + CRTPA V V+ ++ + +
Sbjct: 1305 RVVPETACSLGPSCSSQQFEEPCHVNS--SQLITCRTPALPGLPEDPWVRVEFILDNLVF 1362
Query: 1904 P-----PLLFTYALEDTPFLRGI------IPSRGPPGTEIEITGSNFGFEIL--EISVMI 1950
P F+Y E P L+ + +P R PG+ + G N + E+ MI
Sbjct: 1363 DFATLNPTPFSY--EADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMI 1420
Query: 1951 NNIQCNV 1957
+ C V
Sbjct: 1421 GDGPCVV 1427
Score = 42.4 bits (98), Expect = 0.010
Identities = 47/190 (24%), Positives = 80/190 (42%), Gaps = 42/190 (22%)
Query: 146 PTIRSITPLSGTP--GTLITIQGRIFTDVYGSNIALSSNGKNVRIL--RVYIGGMPCELL 201
P I S+ PL+G GT +TI+G S+ G++V+ + V + G+PC
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRG-------------SNLGQHVQDVLGMVTVAGVPCA-- 1114
Query: 202 IPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLN 261
+ + L G G V T + + ++D+ P+
Sbjct: 1115 VDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRG-VSEHDFAYQDPK---------- 1163
Query: 262 KIAMFQTYAEVTMIFPSQGSIRGGTTLTISG-RFFDQTDFPVRVLVGGEPCDILNVTEN- 319
V IFP++G GGT LT++G + +RV+VG +PC +L ++
Sbjct: 1164 ----------VHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSE 1213
Query: 320 SICCKTPPKP 329
+ C+T P+P
Sbjct: 1214 QLRCETSPRP 1223
Score = 40.4 bits (93), Expect = 0.038
Identities = 49/210 (23%), Positives = 83/210 (39%), Gaps = 17/210 (8%)
Query: 1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEI--SVMINNIQCNVTMANDSVVQCIV-- 1969
P + + P GP GT + I GSN G + ++ V + + C V V +V
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCI 1129
Query: 1970 ----GDHAGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGF- 2024
G+ G V + + +G + ++ P + +I P++G GG +T+ G+
Sbjct: 1130 TGASGEEVAGATAVEVPGRGRGVSEHDFAYQDP-KVHSIFPARGPRAGGTRLTLNGSKLL 1188
Query: 2025 -NPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPF 2083
I +V G + L CE S T A V+V G + +
Sbjct: 1189 TGRLEDIRVVVGDQPCHLLPEQQSEQLRCE-TSPRPTPA--TLPVAVWFGA-TERRLQRG 1244
Query: 2084 TYAVSLTPLITAVSPKRGSTAGGTRLTVVG 2113
+ +L P IT+ P + +GG + V G
Sbjct: 1245 QFKYTLDPNITSAGPTKSFLSGGREICVRG 1274
Score = 37.4 bits (85), Expect = 0.32
Identities = 43/181 (23%), Positives = 72/181 (39%), Gaps = 47/181 (25%)
Query: 31 PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITCDVE- 89
P + + P G ++G TR+TIRG Q Q G + + + C V+
Sbjct: 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLG------------MVTVAGVPCAVDA 1117
Query: 90 KDASHSTQITCYTRAMPED---SYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTP 146
++ S+ + C T A E+ + V V G V+E++ +++ P
Sbjct: 1118 QEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDF---------------AYQDP 1162
Query: 147 TIRSITPLSG--TPGTLITIQG-RIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLIP 203
+ SI P G GT +T+ G ++ T + +RV +G PC LL
Sbjct: 1163 KVHSIFPARGPRAGGTRLTLNGSKLLTG-------------RLEDIRVVVGDQPCHLLPE 1209
Query: 204 Q 204
Q
Sbjct: 1210 Q 1210
>gi|149363636 plexin B2 [Homo sapiens]
Length = 1838
Score = 53.9 bits (128), Expect = 3e-06
Identities = 66/240 (27%), Positives = 97/240 (40%), Gaps = 32/240 (13%)
Query: 1736 QGNCTFSYLESIT-----PYITGVFPNS--VIGSVKVLIEGEGLGTVLEDI---AVFIGN 1785
Q C + L + T P IT + P + + G +++ I G LG DI +V N
Sbjct: 785 QSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRN 844
Query: 1786 QQFRAIEVNENN-----ITALVTPLPVGHHSVSV-VVGSKGLALGNL--TVSSPPVASLS 1837
F+ + + I A TP G V V V G G + N+ T P S+
Sbjct: 845 CSFQPERYSVSTRIVCVIEAAETPFTGG---VEVDVFGKLGRSPPNVQFTFQQPKPLSVE 901
Query: 1838 PTSGSIGGGTTLVITGNGFYPG---NTTVTIGDEPCQIISINPNEVYCRTPAGTTG--MV 1892
P G GGTTL I G G + VT+ PC++ P T G ++
Sbjct: 902 PQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLL 961
Query: 1893 DVKIFVNTIAYPPLLFTYALEDTPFLRGIIPSR--GPPGTEIEITGSNFGFEILEISVMI 1950
+V + + P + FTY + P LR P R G I +TG GF +++ M+
Sbjct: 962 EVSYGGSPVPNPGIFFTY--RENPVLRAFEPLRSFASGGRSINVTGQ--GFSLIQRFAMV 1017
Score = 51.2 bits (121), Expect = 2e-05
Identities = 57/227 (25%), Positives = 91/227 (40%), Gaps = 21/227 (9%)
Query: 1916 PFLRGIIPSRGPPGTEIEIT--GSNFGFEILEIS-VMINNIQCNVTMANDSV---VQCIV 1969
P + I P GP G I IT GSN G + +I + + C+ SV + C++
Sbjct: 803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVI 862
Query: 1970 G----DHAGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFN 2025
GG + + F+ P + ++ P QG GG T+T+ GT +
Sbjct: 863 EAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPL-SVEPQQGPQAGGTTLTIHGTHLD 921
Query: 2026 P---QNSIILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTP 2082
++ + + G C + + + L C + T + EVS G +
Sbjct: 922 TGSQEDVRVTLNGVPCKVTKFGAQ---LQC-VTGPQATRGQMLLEVSY-GGSPVPNPGIF 976
Query: 2083 FTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAE 2129
FTY + P++ A P R +GG + V G GFS + IAE
Sbjct: 977 FTYREN--PVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAE 1021
Score = 49.7 bits (117), Expect = 6e-05
Identities = 41/141 (29%), Positives = 58/141 (41%), Gaps = 7/141 (4%)
Query: 1998 PLNIQNINPSQGSFGGGQTMTVTGTGFNPQN---SIILVCGSECAIDRLRSDYTTLLCEI 2054
P I I P G GGG +T+ G+ Q I V G C+ R +T + +
Sbjct: 802 PPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCV 861
Query: 2055 PSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGS 2114
T EV V S FT+ P +V P++G AGGT LT+ G+
Sbjct: 862 IEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQ---QPKPLSVEPQQGPQAGGTTLTIHGT 918
Query: 2115 GF-SENMEDVHITIAEAKCDV 2134
+ + EDV +T+ C V
Sbjct: 919 HLDTGSQEDVRVTLNGVPCKV 939
Score = 45.4 bits (106), Expect = 0.001
Identities = 38/143 (26%), Positives = 62/143 (43%), Gaps = 13/143 (9%)
Query: 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGGKTCQILHWNF---TDIRCLL 1296
P+IT P+ + G + +TI G N G + + V G+ C + T I C++
Sbjct: 803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVI 862
Query: 1297 PKL-SPGKHDIYVEVRNWGFASTRDKLNSSIQYVLE---VTSMFPQRGSLFGGTEITIRG 1352
+P + V+V + ++Q+ + S+ PQ+G GGT +TI G
Sbjct: 863 EAAETPFTGGVEVDV-----FGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHG 917
Query: 1353 FGFSTIPAENT-VLLGSIPCNVT 1374
T E+ V L +PC VT
Sbjct: 918 THLDTGSQEDVRVTLNGVPCKVT 940
Score = 42.7 bits (99), Expect = 0.008
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDV-HITIAEAKCDVE---YSNKTHIICMT 2146
P+IT + P+ G GG R+T++GS D+ I++A C + YS T I+C+
Sbjct: 803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVI 862
Query: 2147 DA 2148
+A
Sbjct: 863 EA 864
Score = 42.0 bits (97), Expect = 0.013
Identities = 56/224 (25%), Positives = 86/224 (38%), Gaps = 21/224 (9%)
Query: 1067 PLVLAISPSQGSYEEGTILTIVGS--GFSPSSAVTVSVGPVGCSL----LSVDEKELKCQ 1120
P++ I P G G +TI+GS G +SV CS SV + + C
Sbjct: 803 PVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTR-IVCV 861
Query: 1121 ILNGSAGHAPVAVSM-ADV--GLAQNVGGEEFYFVYQSQISHIWPDSGSIAGGTLLTLSG 1177
I A P + DV L ++ +F F +S + P G AGGT LT+ G
Sbjct: 862 I---EAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLS-VEPQQGPQAGGTTLTIHG 917
Query: 1178 ----FGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQATARDAFS 1233
G E+ +V + C V + P+ T G + + V+ G F
Sbjct: 918 THLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGIF- 976
Query: 1234 YNCLQTPIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYV 1277
+ + P++ F P G ++ + G F L Q A+ V
Sbjct: 977 FTYRENPVLRAFEPLRSFASGGRSINVTGQGF--SLIQRFAMVV 1018
Score = 34.7 bits (78), Expect = 2.1
Identities = 20/51 (39%), Positives = 23/51 (45%), Gaps = 1/51 (1%)
Query: 277 PSQGSIRGGTTLTISGRFFDQ-TDFPVRVLVGGEPCDILNVTENSICCKTP 326
P QG GGTTLTI G D + VRV + G PC + C P
Sbjct: 902 PQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGP 952
Score = 33.9 bits (76), Expect = 3.5
Identities = 46/215 (21%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 1157 ISHIWPDSGSIAGGTLLTLSGFGFNENS----KVLVGNETCNVIEGDLN---RITC---- 1205
I+ I P++G + GG +T+ G + ++ V C+ + RI C
Sbjct: 805 ITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVIEA 864
Query: 1206 -RTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYN 1264
TP G V++ V ++ F++ Q P P+ G LTI G +
Sbjct: 865 AETP--FTGGVEVDVFGKLGRSPPNVQFTF---QQPKPLSVEPQQGPQAGGTTLTIHGTH 919
Query: 1265 FGNELTQNMAVYVGGKTCQILHWNFTDIRCLL-PKLSPGKHDIYVEVRNWGFASTRDKLN 1323
+++ V + G C++ + ++C+ P+ + G+ + +EV G +
Sbjct: 920 LDTGSQEDVRVTLNGVPCKVTKFG-AQLQCVTGPQATRGQ--MLLEVSYGGSPVPNPGIF 976
Query: 1324 SSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTI 1358
+ + + + P R GG I + G GFS I
Sbjct: 977 FTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLI 1011
>gi|253795481 plexin B3 isoform 2 [Homo sapiens]
Length = 1932
Score = 51.2 bits (121), Expect = 2e-05
Identities = 91/402 (22%), Positives = 140/402 (34%), Gaps = 51/402 (12%)
Query: 1761 GSVKVLIEGEGLGTVLEDI--AVFIGNQQFR---AIEVNENNITALVTPLPVGHHS-VSV 1814
G + + I G LG D+ AV + ++ ++ I + +P P G V V
Sbjct: 872 GGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVCVTSPAPNGTTGPVRV 931
Query: 1815 VVGSK--GLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYP-GNTTVTIGDEPCQ 1871
+ S+ G++ + T P + SLSP G GGT L I G GNT+ +G +PC
Sbjct: 932 AIKSQPPGISSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRGQHLQTGGNTSAFVGGQPCP 991
Query: 1872 IIS-INPNEVYCRT-PAGTTGMVDVKIFVNTIAYPPLLFTYALEDTPFLRGIIPSRGPPG 1929
I+ + P + CRT P G V + L + P L PS G
Sbjct: 992 ILEPVCPEAIVCRTRPQAAPGEAAVLVVFGHAQRTLLASPFRYTANPQLVAAEPSASFRG 1051
Query: 1930 TEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVMMHHKTKGSA 1989
I G ++++ ++ +V + D+ VQ A P +A
Sbjct: 1052 GGRLIRVRGTGLDVVQRPLL------SVWLEADAEVQ---ASRAQPQDPQPRRSCGAPAA 1102
Query: 1990 MSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTT 2049
+ GGG T N +S +L+C S DR
Sbjct: 1103 DPQACIQ--------------LGGGLLQCSTVCSVN--SSSLLLCRSPAVPDRAHPQRVF 1146
Query: 2050 LLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRL 2109
+ Q S G+ P L PL + G L
Sbjct: 1147 FTLD--------NVQVDFASASGGQGFLYQPNP-----RLAPLSREGPARPYRLKPGHVL 1193
Query: 2110 TVVGSGFSENM--EDVHITIAEAKCDVEYSNKTHIICMTDAH 2149
V G G + + E+V + I +C V+ +TH+ C AH
Sbjct: 1194 DVEGEGLNLGISKEEVRVHIGRGECLVKTLTRTHLYCEPPAH 1235
Score = 45.8 bits (107), Expect = 9e-04
Identities = 60/249 (24%), Positives = 99/249 (39%), Gaps = 20/249 (8%)
Query: 1903 YPPLLFTYALE---DTPFLRGIIPSRGPP--GTEIEITGSNFG--FEILEISVMINNIQC 1955
Y PL A+E P + + P GPP G + I GSN G F ++ +V + + C
Sbjct: 842 YGPLCPPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPC 901
Query: 1956 NVTMA---NDSVVQCIVGDHAGGTF-PVMMHHKTKGSAMSTVVFEY--PLNIQNINPSQG 2009
N + + + C+ GT PV + K++ +S+ F Y P+ + +++P G
Sbjct: 902 NPEPSLYRTSARIVCVTSPAPNGTTGPVRVAIKSQPPGISSQHFTYQDPV-LLSLSPRWG 960
Query: 2010 SFGGGQTMTVTGTGFNPQ-NSIILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEV 2068
GG +T+ G N+ V G C I ++C G +A +
Sbjct: 961 PQAGGTQLTIRGQHLQTGGNTSAFVGGQPCPILEPVCP-EAIVCRTRPQAAPG--EAAVL 1017
Query: 2069 SVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIA 2128
V + +PF Y + P + A P GG + V G+G +
Sbjct: 1018 VVFGHAQRTLLASPFRYTAN--PQLVAAEPSASFRGGGRLIRVRGTGLDVVQRPLLSVWL 1075
Query: 2129 EAKCDVEYS 2137
EA +V+ S
Sbjct: 1076 EADAEVQAS 1084
Score = 44.7 bits (104), Expect = 0.002
Identities = 50/175 (28%), Positives = 70/175 (40%), Gaps = 20/175 (11%)
Query: 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSA---VTVSVGPVGCS---LLSVDEKELKC- 1119
P + A+ P G E G LTI+GS + A VSV C+ L + C
Sbjct: 858 PSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVCV 917
Query: 1120 --QILNGSAGHAPVAVSMADVGLAQNVGGEEFYFVYQSQI-SHIWPDSGSIAGGTLLTLS 1176
NG+ G VA+ G++ +F YQ + + P G AGGT LT+
Sbjct: 918 TSPAPNGTTGPVRVAIKSQPPGISSQ------HFTYQDPVLLSLSPRWGPQAGGTQLTIR 971
Query: 1177 G--FGFNENSKVLVGNETCNVIEGDL-NRITCRT-PKKTEGTVDISVTTNGFQAT 1227
G N+ VG + C ++E I CRT P+ G + V Q T
Sbjct: 972 GQHLQTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQAAPGEAAVLVVFGHAQRT 1026
Score = 43.5 bits (101), Expect = 0.004
Identities = 57/218 (26%), Positives = 89/218 (40%), Gaps = 27/218 (12%)
Query: 1157 ISHIWPDSGSIAGGTLLTLSGFGFNE-----NSKVLVGNETCNVIEGDLNRITCR----- 1206
I + P +G GG LT+ G V V + CN E L R + R
Sbjct: 860 IDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNP-EPSLYRTSARIVCVT 918
Query: 1207 --TPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYN 1264
P T G V +++ + + F+Y Q P++ SP+ G LTI+G +
Sbjct: 919 SPAPNGTTGPVRVAIKSQP-PGISSQHFTY---QDPVLLSLSPRWGPQAGGTQLTIRGQH 974
Query: 1265 FGNELTQNMAVYVGGKTCQILHWNFTD-IRC-LLPKLSPGKHDIYVEVRNWGFASTRDKL 1322
+ N + +VGG+ C IL + I C P+ +PG+ + V +G A R L
Sbjct: 975 L--QTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQAAPGEAAVLVV---FGHAQ-RTLL 1028
Query: 1323 NSSIQYVL--EVTSMFPQRGSLFGGTEITIRGFGFSTI 1358
S +Y ++ + P GG I +RG G +
Sbjct: 1029 ASPFRYTANPQLVAAEPSASFRGGGRLIRVRGTGLDVV 1066
Score = 42.7 bits (99), Expect = 0.008
Identities = 35/121 (28%), Positives = 50/121 (41%), Gaps = 12/121 (9%)
Query: 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVH--ITIAEAKCDVE---YSNKTHIICM 2145
P I AV P G GG LT++GS DV +++A C+ E Y I+C+
Sbjct: 858 PSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVCV 917
Query: 2146 TDAHTLSGWAPVCVHIRGVGMAKLDNADFLYVDAWSSNFS--WGGKSPPEEGSLVVITKG 2203
T PV V I+ + + F Y D + S WG P+ G + +G
Sbjct: 918 TSPAPNGTTGPVRVAIKSQPPG-ISSQHFTYQDPVLLSLSPRWG----PQAGGTQLTIRG 972
Query: 2204 Q 2204
Q
Sbjct: 973 Q 973
Score = 38.1 bits (87), Expect = 0.19
Identities = 23/53 (43%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 277 PSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILN-VTENSICCKTPPK 328
P G GGT LTI G+ QT VGG+PC IL V +I C+T P+
Sbjct: 957 PRWGPQAGGTQLTIRGQHL-QTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQ 1008
Score = 33.1 bits (74), Expect = 6.0
Identities = 30/117 (25%), Positives = 48/117 (41%), Gaps = 4/117 (3%)
Query: 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVGCSLLS-VDEKELKCQILNGS 1125
P++L++SP G GT LTI G + VG C +L V + + C+ +
Sbjct: 950 PVLLSLSPRWGPQAGGTQLTIRGQHLQTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQA 1009
Query: 1126 A-GHAPVAVSMADVGLAQNVGGEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFN 1181
A G A V V + + F + Q+ P + GG L+ + G G +
Sbjct: 1010 APGEAAVLVVFGHA--QRTLLASPFRYTANPQLVAAEPSASFRGGGRLIRVRGTGLD 1064
>gi|29336063 plexin B3 isoform 1 [Homo sapiens]
Length = 1909
Score = 51.2 bits (121), Expect = 2e-05
Identities = 91/402 (22%), Positives = 140/402 (34%), Gaps = 51/402 (12%)
Query: 1761 GSVKVLIEGEGLGTVLEDI--AVFIGNQQFR---AIEVNENNITALVTPLPVGHHS-VSV 1814
G + + I G LG D+ AV + ++ ++ I + +P P G V V
Sbjct: 849 GGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVCVTSPAPNGTTGPVRV 908
Query: 1815 VVGSK--GLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYP-GNTTVTIGDEPCQ 1871
+ S+ G++ + T P + SLSP G GGT L I G GNT+ +G +PC
Sbjct: 909 AIKSQPPGISSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRGQHLQTGGNTSAFVGGQPCP 968
Query: 1872 IIS-INPNEVYCRT-PAGTTGMVDVKIFVNTIAYPPLLFTYALEDTPFLRGIIPSRGPPG 1929
I+ + P + CRT P G V + L + P L PS G
Sbjct: 969 ILEPVCPEAIVCRTRPQAAPGEAAVLVVFGHAQRTLLASPFRYTANPQLVAAEPSASFRG 1028
Query: 1930 TEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVMMHHKTKGSA 1989
I G ++++ ++ +V + D+ VQ A P +A
Sbjct: 1029 GGRLIRVRGTGLDVVQRPLL------SVWLEADAEVQ---ASRAQPQDPQPRRSCGAPAA 1079
Query: 1990 MSTVVFEYPLNIQNINPSQGSFGGGQTMTVTGTGFNPQNSIILVCGSECAIDRLRSDYTT 2049
+ GGG T N +S +L+C S DR
Sbjct: 1080 DPQACIQ--------------LGGGLLQCSTVCSVN--SSSLLLCRSPAVPDRAHPQRVF 1123
Query: 2050 LLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRL 2109
+ Q S G+ P L PL + G L
Sbjct: 1124 FTLD--------NVQVDFASASGGQGFLYQPNP-----RLAPLSREGPARPYRLKPGHVL 1170
Query: 2110 TVVGSGFSENM--EDVHITIAEAKCDVEYSNKTHIICMTDAH 2149
V G G + + E+V + I +C V+ +TH+ C AH
Sbjct: 1171 DVEGEGLNLGISKEEVRVHIGRGECLVKTLTRTHLYCEPPAH 1212
Score = 45.8 bits (107), Expect = 9e-04
Identities = 60/249 (24%), Positives = 99/249 (39%), Gaps = 20/249 (8%)
Query: 1903 YPPLLFTYALE---DTPFLRGIIPSRGPP--GTEIEITGSNFG--FEILEISVMINNIQC 1955
Y PL A+E P + + P GPP G + I GSN G F ++ +V + + C
Sbjct: 819 YGPLCPPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPC 878
Query: 1956 NVTMA---NDSVVQCIVGDHAGGTF-PVMMHHKTKGSAMSTVVFEY--PLNIQNINPSQG 2009
N + + + C+ GT PV + K++ +S+ F Y P+ + +++P G
Sbjct: 879 NPEPSLYRTSARIVCVTSPAPNGTTGPVRVAIKSQPPGISSQHFTYQDPV-LLSLSPRWG 937
Query: 2010 SFGGGQTMTVTGTGFNPQ-NSIILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEV 2068
GG +T+ G N+ V G C I ++C G +A +
Sbjct: 938 PQAGGTQLTIRGQHLQTGGNTSAFVGGQPCPILEPVCP-EAIVCRTRPQAAPG--EAAVL 994
Query: 2069 SVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIA 2128
V + +PF Y + P + A P GG + V G+G +
Sbjct: 995 VVFGHAQRTLLASPFRYTAN--PQLVAAEPSASFRGGGRLIRVRGTGLDVVQRPLLSVWL 1052
Query: 2129 EAKCDVEYS 2137
EA +V+ S
Sbjct: 1053 EADAEVQAS 1061
Score = 44.7 bits (104), Expect = 0.002
Identities = 50/175 (28%), Positives = 70/175 (40%), Gaps = 20/175 (11%)
Query: 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSA---VTVSVGPVGCS---LLSVDEKELKC- 1119
P + A+ P G E G LTI+GS + A VSV C+ L + C
Sbjct: 835 PSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVCV 894
Query: 1120 --QILNGSAGHAPVAVSMADVGLAQNVGGEEFYFVYQSQI-SHIWPDSGSIAGGTLLTLS 1176
NG+ G VA+ G++ +F YQ + + P G AGGT LT+
Sbjct: 895 TSPAPNGTTGPVRVAIKSQPPGISSQ------HFTYQDPVLLSLSPRWGPQAGGTQLTIR 948
Query: 1177 G--FGFNENSKVLVGNETCNVIEGDL-NRITCRT-PKKTEGTVDISVTTNGFQAT 1227
G N+ VG + C ++E I CRT P+ G + V Q T
Sbjct: 949 GQHLQTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQAAPGEAAVLVVFGHAQRT 1003
Score = 43.5 bits (101), Expect = 0.004
Identities = 57/218 (26%), Positives = 89/218 (40%), Gaps = 27/218 (12%)
Query: 1157 ISHIWPDSGSIAGGTLLTLSGFGFNE-----NSKVLVGNETCNVIEGDLNRITCR----- 1206
I + P +G GG LT+ G V V + CN E L R + R
Sbjct: 837 IDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNP-EPSLYRTSARIVCVT 895
Query: 1207 --TPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKGYN 1264
P T G V +++ + + F+Y Q P++ SP+ G LTI+G +
Sbjct: 896 SPAPNGTTGPVRVAIKSQP-PGISSQHFTY---QDPVLLSLSPRWGPQAGGTQLTIRGQH 951
Query: 1265 FGNELTQNMAVYVGGKTCQILHWNFTD-IRC-LLPKLSPGKHDIYVEVRNWGFASTRDKL 1322
+ N + +VGG+ C IL + I C P+ +PG+ + V +G A R L
Sbjct: 952 L--QTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQAAPGEAAVLVV---FGHAQ-RTLL 1005
Query: 1323 NSSIQYVL--EVTSMFPQRGSLFGGTEITIRGFGFSTI 1358
S +Y ++ + P GG I +RG G +
Sbjct: 1006 ASPFRYTANPQLVAAEPSASFRGGGRLIRVRGTGLDVV 1043
Score = 42.7 bits (99), Expect = 0.008
Identities = 35/121 (28%), Positives = 50/121 (41%), Gaps = 12/121 (9%)
Query: 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVH--ITIAEAKCDVE---YSNKTHIICM 2145
P I AV P G GG LT++GS DV +++A C+ E Y I+C+
Sbjct: 835 PSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVCV 894
Query: 2146 TDAHTLSGWAPVCVHIRGVGMAKLDNADFLYVDAWSSNFS--WGGKSPPEEGSLVVITKG 2203
T PV V I+ + + F Y D + S WG P+ G + +G
Sbjct: 895 TSPAPNGTTGPVRVAIKSQPPG-ISSQHFTYQDPVLLSLSPRWG----PQAGGTQLTIRG 949
Query: 2204 Q 2204
Q
Sbjct: 950 Q 950
Score = 38.1 bits (87), Expect = 0.19
Identities = 23/53 (43%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 277 PSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILN-VTENSICCKTPPK 328
P G GGT LTI G+ QT VGG+PC IL V +I C+T P+
Sbjct: 934 PRWGPQAGGTQLTIRGQHL-QTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQ 985
Score = 33.1 bits (74), Expect = 6.0
Identities = 30/117 (25%), Positives = 48/117 (41%), Gaps = 4/117 (3%)
Query: 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVGCSLLS-VDEKELKCQILNGS 1125
P++L++SP G GT LTI G + VG C +L V + + C+ +
Sbjct: 927 PVLLSLSPRWGPQAGGTQLTIRGQHLQTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQA 986
Query: 1126 A-GHAPVAVSMADVGLAQNVGGEEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFN 1181
A G A V V + + F + Q+ P + GG L+ + G G +
Sbjct: 987 APGEAAVLVVFGHA--QRTLLASPFRYTANPQLVAAEPSASFRGGGRLIRVRGTGLD 1041
>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
sapiens]
Length = 1400
Score = 46.2 bits (108), Expect = 7e-04
Identities = 38/148 (25%), Positives = 63/148 (42%), Gaps = 7/148 (4%)
Query: 1793 VNENNITALVTPLPVGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVIT 1852
V N++ VT +P G H V G+ L + P + ++ P G GGT L +
Sbjct: 650 VGPTNVSLTVTNMPPGKHFR--VDGTS--VLRGFSFMEPVLIAVQPLFGPRAGGTCLTLE 705
Query: 1853 GNGFYPGNT-TVTIGDEPCQIISINPNEVYCRTPAG-TTGMVDVKIFVNTIAYPPLLFTY 1910
G G + V + C + ++ ++ C TP G T V + + V A P +T+
Sbjct: 706 GQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGG-AQVPGSWTF 764
Query: 1911 ALEDTPFLRGIIPSRGPPGTEIEITGSN 1938
+ P + I P+ G + I I G +
Sbjct: 765 QYREDPVVLSISPNCGYINSHITICGQH 792
Score = 45.1 bits (105), Expect = 0.002
Identities = 58/235 (24%), Positives = 85/235 (36%), Gaps = 35/235 (14%)
Query: 1056 DCGFTWDSNITPLVLA-ISPSQGSYEEGTILTIVGSGFS-------PSSAVTVSVGPVGC 1107
+C +W + P L P G T LT+ GS F P V+VG C
Sbjct: 557 ECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPC 616
Query: 1108 SLLSVDEKELK------------CQILN-GSAGHAPVAVSMADVGLAQN----VGGEE-- 1148
L D +L+ C++ G+ P VS+ + V G
Sbjct: 617 RPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVL 676
Query: 1149 --FYFVYQSQISHIWPDSGSIAGGTLLTLSG--FGFNENSKVLVGNETCNVIEGDLNRIT 1204
F F+ I+ + P G AGGT LTL G + VLV C + ++
Sbjct: 677 RGFSFMEPVLIA-VQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLL 735
Query: 1205 CRTPK-KTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNL 1258
C TP T +V +S+ G Q F Y + P++ SP I + +
Sbjct: 736 CATPPGATVASVPLSLQVGGAQVPGSWTFQYR--EDPVVLSISPNCGYINSHITI 788
Score = 36.2 bits (82), Expect = 0.71
Identities = 38/170 (22%), Positives = 64/170 (37%), Gaps = 35/170 (20%)
Query: 1831 PPVASLSPTSGSIGGGTTLVITGNGFY--------PGNTTVTIGDEPCQII-----SINP 1877
P + P SG + G T L + G+ FY G VT+G PC+ + + P
Sbjct: 569 PKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRP 628
Query: 1878 -------NEVYCR-TPAGTTGMVDVKIFVNTIAYPPLLFTYALEDTPFLRG--------- 1920
E C P GT + + + PP + ++ T LRG
Sbjct: 629 VPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKH-FRVDGTSVLRGFSFMEPVLI 687
Query: 1921 -IIPSRGP--PGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQC 1967
+ P GP GT + + G + +V++N +C + ++ + C
Sbjct: 688 AVQPLFGPRAGGTCLTLEGQSLSVGTSR-AVLVNGTECLLARVSEGQLLC 736
Score = 35.0 bits (79), Expect = 1.6
Identities = 50/188 (26%), Positives = 72/188 (38%), Gaps = 22/188 (11%)
Query: 146 PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNGKNVR-ILRVYIGGMPCELLIPQ 204
P + P SG ++G + GSN L +G +V +G PC L
Sbjct: 569 PKLTEFHPHSGP------LRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKD 622
Query: 205 SDNLYGLKLDHPNGD-MGSMVCKTT--GT-FIGHHNVSFILDNDYGRSFPQKMAYFVSSL 260
S L + P D + C+ GT +G NVS + N P + V
Sbjct: 623 SSKLRPV----PRKDFVEEFECELEPLGTQAVGPTNVSLTVTN-----MPPGKHFRVDGT 673
Query: 261 NKIAMFQTYAEVTM-IFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTEN 319
+ + F V + + P G GGT LT+ G+ VLV G C + V+E
Sbjct: 674 SVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLS-VGTSRAVLVNGTECLLARVSEG 732
Query: 320 SICCKTPP 327
+ C TPP
Sbjct: 733 QLLCATPP 740
>gi|32967607 glutathione peroxidase 2 [Homo sapiens]
Length = 190
Score = 36.6 bits (83), Expect = 0.55
Identities = 43/153 (28%), Positives = 64/153 (41%), Gaps = 17/153 (11%)
Query: 266 FQTYAEVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKT 325
F T+ ++ + S+ G TT + Q FP R++V G PC+ EN C+
Sbjct: 23 FNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQEN---CQN 79
Query: 326 PPKPHILKTVYPGG-------RGLKLEV-WNNSRPI--RLEEILEYNEKTPGYMGASWVD 375
+ LK V PGG K EV N P+ L++ L Y P + D
Sbjct: 80 EEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSL---MTD 136
Query: 376 SASYIWLMEQDTFVA-RFSGFLVAPDSDVYRFY 407
IW + + VA F FL+ P+ + +R Y
Sbjct: 137 PKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRY 169
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 34.7 bits (78), Expect = 2.1
Identities = 26/81 (32%), Positives = 39/81 (48%), Gaps = 6/81 (7%)
Query: 2302 LAHTAKAGERI----LILQEAVTWKPGDNIVIASTGHRHSQGENEKMTIASVSADGINIT 2357
+A +AG +I L + A+T K +N A+ GHR S + + ++ G +T
Sbjct: 2851 MAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVT 2910
Query: 2358 L--SNPLNYTHLGITVTLPDG 2376
L SNP HL + TL DG
Sbjct: 2911 LDSSNPAAGLHLQLNYTLLDG 2931
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 34.7 bits (78), Expect = 2.1
Identities = 26/81 (32%), Positives = 39/81 (48%), Gaps = 6/81 (7%)
Query: 2302 LAHTAKAGERI----LILQEAVTWKPGDNIVIASTGHRHSQGENEKMTIASVSADGINIT 2357
+A +AG +I L + A+T K +N A+ GHR S + + ++ G +T
Sbjct: 2851 MAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVT 2910
Query: 2358 L--SNPLNYTHLGITVTLPDG 2376
L SNP HL + TL DG
Sbjct: 2911 LDSSNPAAGLHLQLNYTLLDG 2931
>gi|209862845 nuclear factor of activated T-cells, cytoplasmic,
calcineurin-dependent 4 isoform 1 [Homo sapiens]
Length = 964
Score = 34.3 bits (77), Expect = 2.7
Identities = 27/117 (23%), Positives = 52/117 (44%), Gaps = 15/117 (12%)
Query: 2001 IQNINPSQGSFGGGQTMTVTGTGFNPQNSIILV---------CGSECAIDRLRSDYTTLL 2051
++ +PS S GG+ + +TG+ F P + ++ + E ++RL+S+ TL
Sbjct: 651 VEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEATVNRLQSNEVTLT 710
Query: 2052 CEIPSNNGTGAEQACEV--SVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGG 2106
+P + + +V V NG+ + +P T + P+I P S+ G
Sbjct: 711 LTVPEYSNKRVSRPVQVYFYVSNGR---RKRSP-TQSFRFLPVICKEEPLPDSSLRG 763
Score = 33.1 bits (74), Expect = 6.0
Identities = 16/39 (41%), Positives = 23/39 (58%)
Query: 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEP 1869
P V + SP++ S+ GG LV+TG+ F P + V I P
Sbjct: 649 PQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGP 687
>gi|27886563 nuclear factor of activated T-cells, cytoplasmic,
calcineurin-dependent 4 isoform 2 [Homo sapiens]
Length = 902
Score = 34.3 bits (77), Expect = 2.7
Identities = 27/117 (23%), Positives = 52/117 (44%), Gaps = 15/117 (12%)
Query: 2001 IQNINPSQGSFGGGQTMTVTGTGFNPQNSIILV---------CGSECAIDRLRSDYTTLL 2051
++ +PS S GG+ + +TG+ F P + ++ + E ++RL+S+ TL
Sbjct: 588 VEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEATVNRLQSNEVTLT 647
Query: 2052 CEIPSNNGTGAEQACEV--SVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGG 2106
+P + + +V V NG+ + +P T + P+I P S+ G
Sbjct: 648 LTVPEYSNKRVSRPVQVYFYVSNGR---RKRSP-TQSFRFLPVICKEEPLPDSSLRG 700
Score = 33.1 bits (74), Expect = 6.0
Identities = 16/39 (41%), Positives = 23/39 (58%)
Query: 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEP 1869
P V + SP++ S+ GG LV+TG+ F P + V I P
Sbjct: 586 PQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGP 624
>gi|57546899 myeloid/lymphoid or mixed-lineage leukemia translocated
to, 10 isoform b [Homo sapiens]
Length = 1011
Score = 34.3 bits (77), Expect = 2.7
Identities = 32/123 (26%), Positives = 49/123 (39%), Gaps = 17/123 (13%)
Query: 1776 LEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHH------SVSVVVGSKGLALGNLTVS 1829
L D ++ + NQ + + ++ +AL TP P G VS V G+ +G L
Sbjct: 822 LPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASG 881
Query: 1830 SPPVASLSPTSGSIGG------GTTLVITG-----NGFYPGNTTVTIGDEPCQIISINPN 1878
PV S P ++GG G L I G NG T++ P ++ PN
Sbjct: 882 MQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPN 941
Query: 1879 EVY 1881
+
Sbjct: 942 ATH 944
>gi|4757726 myeloid/lymphoid or mixed-lineage leukemia translocated
to, 10 isoform a [Homo sapiens]
Length = 1027
Score = 34.3 bits (77), Expect = 2.7
Identities = 32/123 (26%), Positives = 49/123 (39%), Gaps = 17/123 (13%)
Query: 1776 LEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHH------SVSVVVGSKGLALGNLTVS 1829
L D ++ + NQ + + ++ +AL TP P G VS V G+ +G L
Sbjct: 838 LPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASG 897
Query: 1830 SPPVASLSPTSGSIGG------GTTLVITG-----NGFYPGNTTVTIGDEPCQIISINPN 1878
PV S P ++GG G L I G NG T++ P ++ PN
Sbjct: 898 MQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPN 957
Query: 1879 EVY 1881
+
Sbjct: 958 ATH 960
>gi|31415878 early B-cell factor [Homo sapiens]
Length = 591
Score = 34.3 bits (77), Expect = 2.7
Identities = 14/44 (31%), Positives = 24/44 (54%)
Query: 2084 TYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITI 2127
+Y TP I A+SP G T GG + ++G F + ++ + T+
Sbjct: 255 SYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTM 298
>gi|53828926 early B-cell factor 3 [Homo sapiens]
Length = 551
Score = 33.5 bits (75), Expect = 4.6
Identities = 14/38 (36%), Positives = 22/38 (57%)
Query: 2090 TPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITI 2127
TP I A+SP G T GG + ++G F + ++ V T+
Sbjct: 253 TPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTM 290
Score = 32.7 bits (73), Expect = 7.9
Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Query: 1829 SSPPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVTIGDEPCQIISINPNEVYCRT-PAG 1887
++P + ++SP+ G GG T++I G+ F+ G V G I P+ + +T P
Sbjct: 252 ATPCIKAISPSEGWTTGGATVIIIGDNFFDG-LQVVFGTMLVWSELITPHAIRVQTPPRH 310
Query: 1888 TTGMVDVKI 1896
G+V+V +
Sbjct: 311 IPGVVEVTL 319
>gi|113930703 early B-cell factor 2 [Homo sapiens]
Length = 575
Score = 33.5 bits (75), Expect = 4.6
Identities = 14/38 (36%), Positives = 22/38 (57%)
Query: 2090 TPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITI 2127
TP I A+SP G T GG + ++G F + ++ V T+
Sbjct: 252 TPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGTM 289
>gi|149588928 SLAIN motif family, member 2 [Homo sapiens]
Length = 581
Score = 33.5 bits (75), Expect = 4.6
Identities = 27/88 (30%), Positives = 43/88 (48%), Gaps = 18/88 (20%)
Query: 4001 PIQFISN---GTTGQMQLSELQEIAGSLGQAVILGNISSILGFNISSMSITNP------- 4050
P++ SN G+ G ++++L + S G ++ +S+ NI+S ++T P
Sbjct: 474 PVKAFSNHGSGSPGSQEITQLTQTTSSPGPPMVQSTVSANPPSNINSATLTRPAGTTAMR 533
Query: 4051 --LPSPS--DSGWIKV----TAQPVERS 4070
LP PS +G I V AQPV RS
Sbjct: 534 SGLPRPSAPSAGGIPVPRSKLAQPVRRS 561
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 165,619,182
Number of Sequences: 37866
Number of extensions: 7766928
Number of successful extensions: 16714
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 15837
Number of HSP's gapped (non-prelim): 422
length of query: 4243
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4120
effective length of database: 13,590,000
effective search space: 55990800000
effective search space used: 55990800000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.