Search of human proteins with 37537701

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37537701 SAPS domain family, member 2 [Homo sapiens]
         (932 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37537701 SAPS domain family, member 2 [Homo sapiens]              1879   0.0  
gi|13489083 SAPS domain family, member 3 [Homo sapiens]               700   0.0  
gi|151101459 SAPS domain family, member 1 [Homo sapiens]              652   0.0  
gi|169218088 PREDICTED: similar to SAPS domain family, member 2 ...    92   2e-18
gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo ...    51   6e-06
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         47   1e-04
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             46   1e-04
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    45   4e-04
gi|210032509 hypothetical protein LOC100130302 [Homo sapiens]          45   4e-04
gi|33946327 nucleoporin 214kDa [Homo sapiens]                          44   7e-04
gi|163965366 nascent polypeptide-associated complex alpha subuni...    44   0.001
gi|55741677 SET domain containing 1A [Homo sapiens]                    43   0.001
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     43   0.001
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    43   0.002
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    41   0.005
gi|209862845 nuclear factor of activated T-cells, cytoplasmic, c...    41   0.006
gi|27886563 nuclear factor of activated T-cells, cytoplasmic, ca...    41   0.006
gi|117938759 GNAS complex locus XLas [Homo sapiens]                    40   0.008
gi|239745807 PREDICTED: keratin associated protein 4-9 [Homo sap...    40   0.008
gi|30795231 brain abundant, membrane attached signal protein 1 [...    40   0.010
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    40   0.010
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    40   0.010
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    40   0.010
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    40   0.010
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    40   0.010
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    40   0.010
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    40   0.010
gi|222418647 mucin 7, secreted precursor [Homo sapiens]                40   0.013
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...    40   0.013
gi|222418649 mucin 7, secreted precursor [Homo sapiens]                40   0.013

>gi|37537701 SAPS domain family, member 2 [Homo sapiens]
          Length = 932

 Score = 1879 bits (4867), Expect = 0.0
 Identities = 932/932 (100%), Positives = 932/932 (100%)

Query: 1   MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSL 60
           MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSL
Sbjct: 1   MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSL 60

Query: 61  ITQDPPLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLL 120
           ITQDPPLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLL
Sbjct: 61  ITQDPPLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLL 120

Query: 121 ASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQ 180
           ASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQ
Sbjct: 121 ASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQ 180

Query: 181 DVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLT 240
           DVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLT
Sbjct: 181 DVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLT 240

Query: 241 ALESQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVDSFSQGLERSYAV 300
           ALESQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVDSFSQGLERSYAV
Sbjct: 241 ALESQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVDSFSQGLERSYAV 300

Query: 301 SSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPS 360
           SSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPS
Sbjct: 301 SSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPS 360

Query: 361 INQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPP 420
           INQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPP
Sbjct: 361 INQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPP 420

Query: 421 HENGNRSLETPQPAASLPDNTMVTHLFQKCCLVQRILEAWEANDHTQAAGGMRRGNMGHL 480
           HENGNRSLETPQPAASLPDNTMVTHLFQKCCLVQRILEAWEANDHTQAAGGMRRGNMGHL
Sbjct: 421 HENGNRSLETPQPAASLPDNTMVTHLFQKCCLVQRILEAWEANDHTQAAGGMRRGNMGHL 480

Query: 481 TRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLAFSDYQ 540
           TRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLAFSDYQ
Sbjct: 481 TRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLAFSDYQ 540

Query: 541 IQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRI 600
           IQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRI
Sbjct: 541 IQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRI 600

Query: 601 QPFDDDEDEDIWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDA 660
           QPFDDDEDEDIWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDA
Sbjct: 601 QPFDDDEDEDIWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDA 660

Query: 661 PGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPE 720
           PGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPE
Sbjct: 661 PGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPE 720

Query: 721 EKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRK 780
           EKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRK
Sbjct: 721 EKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRK 780

Query: 781 APLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSR 840
           APLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSR
Sbjct: 781 APLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSR 840

Query: 841 LLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAV 900
           LLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAV
Sbjct: 841 LLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAV 900

Query: 901 TAAPAMVATLGTVTKDGKTDAPPEGAALNGPV 932
           TAAPAMVATLGTVTKDGKTDAPPEGAALNGPV
Sbjct: 901 TAAPAMVATLGTVTKDGKTDAPPEGAALNGPV 932


>gi|13489083 SAPS domain family, member 3 [Homo sapiens]
          Length = 793

 Score =  700 bits (1806), Expect = 0.0
 Identities = 396/875 (45%), Positives = 525/875 (60%), Gaps = 112/875 (12%)

Query: 1   MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSL 60
           MFWKFDL+++SH+D LL++E VTL+ELMDE+D+LQECKAQN+KL++FL + +C+E+LVS 
Sbjct: 1   MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSF 60

Query: 61  ITQDPPLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLL 120
           I ++PP DM+EK+R+KYPN +CELLT DV Q++DRLG DESLL  LY FL ++ PLNPLL
Sbjct: 61  IIEEPPQDMDEKIRYKYPNISCELLTSDVSQMNDRLGEDESLLMKLYSFLLNDSPLNPLL 120

Query: 121 ASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQ 180
           ASFFSK +  LI+RK EQ++ FLKKK  F+ L++KHIGTSA+MDLLLRL++C+EP   RQ
Sbjct: 121 ASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ 180

Query: 181 DVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLT 240
           DVL+WLNEEK+IQRLVE++HPSQ+EDR SNASQ+LC+IVRL RDQ  Q+Q + EPDPLL 
Sbjct: 181 DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLA 240

Query: 241 ALESQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVDSFSQGLERS-YA 299
            LE Q+ +EQLL N+F  ++ ES +VS  Q+LLTLLETRR   EG ++    G+  S  +
Sbjct: 241 TLEKQEIIEQLLSNIFHKEKNESAIVSAIQILLTLLETRRPTFEGHIEICPPGMSHSACS 300

Query: 300 VSSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTP 359
           V+ SVL  I  RL  FH+LLL PPK                                   
Sbjct: 301 VNKSVLEAIRGRLGSFHELLLEPPK----------------------------------- 325

Query: 360 SINQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEP 419
                           ++FFKYTWNNFLH QVE+CIA IL+                   
Sbjct: 326 ----------------NMFFKYTWNNFLHTQVEICIALILA------------------S 351

Query: 420 PHENGNRSLETPQPAASLPDNTMVTHLFQKCCLVQRILEAWEANDHTQAAGGMRRGNMGH 479
           P EN   +  T Q   S  DN ++ HLFQKC L++RILEAWE N+  QA GG R G MGH
Sbjct: 352 PFENTENATITDQD--STGDNLLLKHLFQKCQLIERILEAWEMNEKKQAEGGRRHGYMGH 409

Query: 480 LTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLAFSDY 539
           LTRIAN +V + ++GP    + ++I+ LP + R RWE+F   +L ETN+RNTVDLAFSDY
Sbjct: 410 LTRIANCIVHSTDKGPNSALVQQLIKDLPDEVRERWETFCTSSLGETNKRNTVDLAFSDY 469

Query: 540 QIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDR 599
           Q+QQMT+NF+DQFGFNDE+FADQDD  N  FDR+++INF ++ +E S + ALFEACC +R
Sbjct: 470 QMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNE-SGNIALFEACCKER 528

Query: 600 IQPFDD--DEDEDIWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAH 657
           IQ FDD   ++EDIWE+           R   G+  + ES      +   QD        
Sbjct: 529 IQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQD-------- 580

Query: 658 RDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTS 717
                    P+    E       SE   W+A FD P  +T  AP  +  VGS VW+    
Sbjct: 581 ------LFEPSSANTEDKMEVDLSEPPNWSANFDVPMETTHGAP--LDSVGSDVWSTEEP 632

Query: 718 AP-EEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVC 776
            P +E GWA F++F     ++   R +SPV+ E S           +   P +P A  + 
Sbjct: 633 MPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETS----------TEPMDPLTPSAAALA 682

Query: 777 VTRKAP-LLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAV---- 831
           V  +A   +A ++SS G   +E  D+      + V  G  +E   L   A+TE AV    
Sbjct: 683 VQPEAAGSVAMEASSDGEEDAESTDK----VTETVMNGGMKETLSLTVDAKTETAVFKSE 738

Query: 832 -GRVGCADSRLLSPACPAPKEVTAAPAVAVPPEAT 865
            G++  +       A   P+   A  A   PP ++
Sbjct: 739 EGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSS 773


>gi|151101459 SAPS domain family, member 1 [Homo sapiens]
          Length = 881

 Score =  652 bits (1682), Expect = 0.0
 Identities = 385/930 (41%), Positives = 531/930 (57%), Gaps = 120/930 (12%)

Query: 1   MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSL 60
           MFWKFDL+T+SH+D LL++E ++L EL+DE+D+LQECK  N+KLLDFL +   ++ +V+ 
Sbjct: 1   MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAW 60

Query: 61  ITQDPPLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLL 120
           +TQ+PP   EE++R+KYP+ ACE+LT DVPQI+D LG DESLL+ LY FL     LNPLL
Sbjct: 61  VTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNPLL 120

Query: 121 ASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQ 180
           ASFFSK +G LI RKT+Q+++FL+KKD F+ L+L+HIGTSA+MDLLLRL++CVE   LRQ
Sbjct: 121 ASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQ 180

Query: 181 DVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLT 240
           DV++WLNEEK++QRL+E IHPS+DE++ SNASQ+LCDI+RL R+Q  Q+Q++ EPD LL 
Sbjct: 181 DVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLA 240

Query: 241 ALESQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTE------------GLVD 288
            LE Q+ +EQLL NMF+G++++S +VSG QVLLTLLE RR  +E            G ++
Sbjct: 241 TLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLE 300

Query: 289 SFSQGLERSYAVSSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGAR 348
             +QG   S   S   LH + PRL  FHQLLL PPK + +  T G+L  PLGN RLH  +
Sbjct: 301 LLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVK 360

Query: 349 LMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERT 408
           L+A+ L  N  ++  EL  L+  + +LDLFF Y +NNFLH QVE C++ +LS        
Sbjct: 361 LLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLS-------- 412

Query: 409 EASGSESRVEPPHENGNRSLETPQPAASLPDNTMVTHLFQKCCLVQRILEAWEANDHTQA 468
                   + PP ++   S ETP        N +V HL Q+C LV+RIL +WE ND  Q 
Sbjct: 413 --------LGPPPDS---SPETP------IQNPVVKHLLQQCRLVERILTSWEENDRVQC 455

Query: 469 AGGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNR 528
           AGG R+G MGHLTR+A A+VQN E+GP    + ++++ LP++ + +WE+FV   L ETN+
Sbjct: 456 AGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNK 515

Query: 529 RNTVDL------------------------------AFSDYQIQQMTANFVDQFGFNDEE 558
           +N VDL                              AF D+Q+Q+MT+ F+D FGFNDEE
Sbjct: 516 KNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEE 575

Query: 559 FADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRIQPFDDDEDED-------- 610
           F +Q++++NAPFD+ A I F+++AD+++P+A L E C  DRIQ FDDDE+E+        
Sbjct: 576 FGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGS 635

Query: 611 --------IWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDAPG 662
                    W+ S     AR+   P  G      + S++  E   ++ +        A G
Sbjct: 636 GESDGEDGAWQGSQLARGARLGQPP--GVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARG 693

Query: 663 AGAP---PAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAP 719
              P   P+PG +  PP      G  WTA FD      PT+P   R  G      G  AP
Sbjct: 694 GATPLSYPSPGPQ--PP------GPSWTATFDPVPTDAPTSP---RVSGEEELHTGPPAP 742

Query: 720 EEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTR 779
           +           P    +  P   S        A   RSQ P    +P      +     
Sbjct: 743 Q----------GPLSVPQGLP-TQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEP 791

Query: 780 KAP--LLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPL-----PTVARTEEAVG 832
            AP   L S        H   G + A S+ D+ +R P    P       P     E++  
Sbjct: 792 SAPCQALVSIGDLQATFH---GIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPE 848

Query: 833 RVGCADSRLLSPACPAPKEVTAAPAVAVPP 862
            +G   S+      P P    +AP     P
Sbjct: 849 PLGLPQSQSAQALTPPPIPNGSAPEGPASP 878


>gi|169218088 PREDICTED: similar to SAPS domain family, member 2
           [Homo sapiens]
          Length = 79

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 44/44 (100%), Positives = 44/44 (100%)

Query: 163 MDLLLRLVSCVEPAGLRQDVLHWLNEEKVIQRLVELIHPSQDED 206
           MDLLLRLVSCVEPAGLRQDVLHWLNEEKVIQRLVELIHPSQDED
Sbjct: 1   MDLLLRLVSCVEPAGLRQDVLHWLNEEKVIQRLVELIHPSQDED 44


>gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo
           sapiens]
          Length = 907

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 42/129 (32%), Positives = 54/129 (41%), Gaps = 14/129 (10%)

Query: 799 GDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAV 858
           GD  AAS  +A +   G  AP  PT      A     C+ +    P  P+     AAP +
Sbjct: 441 GDAFAASPGEAPAASEGAAAPATPTPV----AAALDACSGN---DPFAPSEGSAEAAPEL 493

Query: 859 AV----PPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVATLGTVT 914
            +    PPE +V + T  +   P +P  A S A AVA       A TAA A   T  T +
Sbjct: 494 DLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAAAA---ATTAATAAATTTTTTS 550

Query: 915 KDGKTDAPP 923
               T APP
Sbjct: 551 AATATTAPP 559



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 58/268 (21%), Positives = 82/268 (30%), Gaps = 16/268 (5%)

Query: 650 GKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGS 709
           G+ SL A    P       P   E  P    +E A  TA       +T TA     D+  
Sbjct: 384 GEDSLAALSSVPSEAQISDPFAPEPTPPTTTAEIA--TASASASTTTTVTAVTAEVDLFG 441

Query: 710 SVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPAS 769
             +AA                 P   + +   CS   +   + +EGS    PE       
Sbjct: 442 DAFAASPGEAPAASEGAAAPATPTPVAAALDACSG--NDPFAPSEGSAEAAPELDLFAMK 499

Query: 770 PCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEE 829
           P   +V V       A    ++  S         A A+ A +           T   T  
Sbjct: 500 PPETSVPVVTPTASTAPPVPATAPS--------PAPAVAAAAAATTAATAAATTTTTTSA 551

Query: 830 AVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALSK----AGPAIPTPAVS 885
           A          +      +  EV AAP     P   +  T A S     A P   +   +
Sbjct: 552 ATATTAPPALDIFGDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTA 611

Query: 886 SALAVAVPLGPIMAVTAAPAMVATLGTV 913
             L+V     P  A TA+PA V + G +
Sbjct: 612 DLLSVDAFAAPSPATTASPAKVDSSGVI 639


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 56/243 (23%), Positives = 93/243 (38%), Gaps = 29/243 (11%)

Query: 632  PHASESCSKNGPERGGQDGKASLEAHRDAPG-----AGAPPAPGKKEAPPVEGDSEGAMW 686
            P A+ S     P     DG  + E     PG     +G P +P K +A     + +GA  
Sbjct: 2505 PPAAGSSEPKAPWPKATDGDLAQEP---GPGLTFEDSGNPKSPDKAQA-----EQDGA-- 2554

Query: 687  TAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFC------CSESGP 740
                +E  +S+ ++ G      SS  +   +  EE+G     +    C      CS +  
Sbjct: 2555 ----EESESSSSSSSGSSSSSSSSSSSGSETEGEEEG---DKNGDGGCGTGGRNCSAASS 2607

Query: 741  RCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGD 800
            R +SP  +  S +  S S     + S +S  + +   +  +   +S SSSS  S S    
Sbjct: 2608 RAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2667

Query: 801  QKAASAMDAVSRGPGREAPPLPTVA-RTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVA 859
              +++  +  S     EA P PT     + A+       +    P+  +P + T AP   
Sbjct: 2668 SSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQ 2727

Query: 860  VPP 862
             PP
Sbjct: 2728 APP 2730



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 33/152 (21%), Positives = 52/152 (34%), Gaps = 10/152 (6%)

Query: 786  SDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPA 845
            S  +S      +DG    +    A +RG GR+    P+     +    +   +     P+
Sbjct: 2304 SRKTSKDTGEGKDGGTAGSEEPGAKARGRGRK----PSAKAKGDRAATLEEGNPTDEVPS 2359

Query: 846  CPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLG------PIMA 899
             P   E ++ P     P   V       KA PA P P+ +     + P        P  A
Sbjct: 2360 TPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPA 2419

Query: 900  VTAAPAMVATLGTVTKDGKTDAPPEGAALNGP 931
             + APA + T+       K     E +   GP
Sbjct: 2420 TSLAPAPLITMPATRPKPKKARAAEESGAKGP 2451



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 22/61 (36%), Positives = 28/61 (45%), Gaps = 7/61 (11%)

Query: 785 ASDSSSSGGSHSEDGDQKAASAMDAVSR---GPGREAPPL----PTVARTEEAVGRVGCA 837
           A  + + GG HS     K +S+ D  ++   G G E PPL       AR EEA G  G  
Sbjct: 180 APSARTPGGGHSSGAPAKGSSSRDGPAKERAGRGGEPPPLFGKKDPRARGEEASGPRGVV 239

Query: 838 D 838
           D
Sbjct: 240 D 240


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 69/260 (26%), Positives = 94/260 (36%), Gaps = 28/260 (10%)

Query: 666  PPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWA 725
            P  P      P E D+  A+  +  +EPA+     P           AA    PEE    
Sbjct: 974  PVTPATTVHAPEEPDT-AAVRVSTPEEPASPAAAVPTPEEPTSP---AAAVPTPEEPTSP 1029

Query: 726  KFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLA 785
                  P     + P  + P   E + +  +    PE+  SPA+        T  A  + 
Sbjct: 1030 AAAVPPPE--EPTSPAAAVPTPEEPT-SPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVP 1086

Query: 786  SDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPA 845
            +    +  + +    ++  S   AV   P   A P   V   EE               A
Sbjct: 1087 TPEEPTSPAAAVPTPEEPTSPAAAVPT-PEEPASPAAAVPTPEEPASPAA---------A 1136

Query: 846  CPAPKEVT-AAPAVAVPPE---ATVAITTALSKAGPA--IPTPAVSSALAVAV-----PL 894
             P P+E    APAV  P E   A VA+ T    A PA  +PTPA S++ A  V     P 
Sbjct: 1137 VPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPT 1196

Query: 895  GPIMAVTAAPAMVATLGTVT 914
             P  +V    AMVATL   T
Sbjct: 1197 SPAASVPTPAAMVATLEEFT 1216



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 64/246 (26%), Positives = 88/246 (35%), Gaps = 34/246 (13%)

Query: 663  AGAPPAPGKKEAPP--VEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPE 720
            A A P P +  +P   V    E A   A    P      AP V     S+  A     PE
Sbjct: 1108 AAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPE 1167

Query: 721  EKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRK 780
            E                + P  + P   E +      +   E    P SP A    V   
Sbjct: 1168 ES---------------ASPAAAVPTPAESASFAAVVATLEE----PTSPAA---SVPTP 1205

Query: 781  APLLASDSSSSGGSHSEDGDQKAASAMDAVSRG--PGREAPPLPTVARTEEAVGRVGCAD 838
            A ++A+    +  + S    ++ AS   AVS    P   A  +PT+     +   V    
Sbjct: 1206 AAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAV-LTP 1264

Query: 839  SRLLSPACPAPK-EVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPI 897
              L SPA   P  E  A+PA AV      A   A      A+PTP V++  A +VP   +
Sbjct: 1265 EELSSPAASVPTPEEPASPAAAVSNLEEPASPAA------AVPTPEVAAIPAASVPTPEV 1318

Query: 898  MAVTAA 903
             A+ AA
Sbjct: 1319 PAIPAA 1324



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 74/295 (25%), Positives = 98/295 (33%), Gaps = 48/295 (16%)

Query: 663  AGAPPAPGKKEAPPVEGD-SEGAMWTAVFDEPANSTPTAPGVVRDVGSSV-------WAA 714
            A A  AP +   P V     EG    A    P  + P     +   G S        WAA
Sbjct: 898  AAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAA 957

Query: 715  -----------GTS-----------APEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSH 752
                       GT            APEE   A      P     + P  + P   E + 
Sbjct: 958  LAITVPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPE--EPASPAAAVPTPEEPT- 1014

Query: 753  AEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSR 812
            +  +    PE+  SPA+        T  A  + +    +  + +    ++  S   AV  
Sbjct: 1015 SPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPT 1074

Query: 813  GPGREAPPLPTVARTEEAVGRVGCADS--RLLSPACPAPK-EVTAAPAVAVP-------P 862
             P     P   V   EE         +     SPA   P  E  A+PA AVP       P
Sbjct: 1075 -PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASP 1133

Query: 863  EATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAA----PAMVATLGTV 913
             A V      +   PA+PTP  S++ AVAVP     A  AA    PA  A+   V
Sbjct: 1134 AAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAV 1188



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 60/232 (25%), Positives = 78/232 (33%), Gaps = 19/232 (8%)

Query: 643  PERGGQDGKASLEAHRDAPGAGAPPAPGKKE--APPVEGDSEGAMWTAVFDEPANSTPTA 700
            PE       A       A  A A P P +    AP V    E A        P  S   A
Sbjct: 1114 PEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPA 1173

Query: 701  PGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSES-----GPRCSSPVDTECSHAEG 755
              V     S+ +AA  +  EE      +   P     +      P  S P   E +    
Sbjct: 1174 AAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAA 1233

Query: 756  SRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPG 815
            + S  PE+  SPA+        T  A  + +    S  + S    ++ AS   AVS    
Sbjct: 1234 AVSN-PEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSN--- 1289

Query: 816  REAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVA 867
             E P  P  A     V  +  A       + P P EV A PA AVPP   V+
Sbjct: 1290 LEEPASPAAAVPTPEVAAIPAA-------SVPTP-EVPAIPAAAVPPMEEVS 1333



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 63/263 (23%), Positives = 90/263 (34%), Gaps = 30/263 (11%)

Query: 663  AGAPPAPGKKEAPP--VEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPE 720
            A A P P +  +P   V    E     A    P   T  A  V      +  AA    PE
Sbjct: 1043 AAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPE 1102

Query: 721  EK---GWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAF-SPASPCAWNVC 776
            E      A  T  +P     + P  + P   E +    +     E AF +PA P      
Sbjct: 1103 EPTSPAAAVPTPEEP-----ASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESA 1157

Query: 777  VTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVAR--------TE 828
                A     +S+S   +     +  + +A+ A    P   A  +PT A         T 
Sbjct: 1158 SAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTS 1217

Query: 829  EAVGRVGCADSRLLSPACPAPKEVT----AAPAVAVPPEATVAITT--ALSKAGPAIPTP 882
             A       +   L+ A   P+E T    A P +  P  +  A+ T   LS    ++PTP
Sbjct: 1218 PAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTP 1277

Query: 883  AVSSALAVAV-----PLGPIMAV 900
               ++ A AV     P  P  AV
Sbjct: 1278 EEPASPAAAVSNLEEPASPAAAV 1300


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 80/312 (25%), Positives = 108/312 (34%), Gaps = 54/312 (17%)

Query: 630 GAPHASESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPGKKE-APPVEGDSEGAMWTA 688
           G     ES  + GP R    G +S         A  PPA G+ E APP +  S G     
Sbjct: 66  GGATIPESAPRAGPTRSA--GTSSRNP------ASRPPASGRGERAPPAKNTSPG----- 112

Query: 689 VFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESG--------- 739
               P +S   A G  R           SA E     K T+        +G         
Sbjct: 113 ----PVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 168

Query: 740 PRCSSPVDTECSHAEGSR---------------SQGPEKAFSPASPCAWNVCVTRKAPLL 784
           P   SP     S A G+                ++GP K+ S AS  +     T  +P  
Sbjct: 169 PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS----TTEPSPAA 224

Query: 785 ASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSP 844
               S+ GG         ++SA    S  P R  P      R      +      + L P
Sbjct: 225 RRRPSAGGGLQRPASRSLSSSATPLSS--PARSGPSARGTPRAPAHPSQPKPKGLQALRP 282

Query: 845 ACPAPKEVTAAPA---VAVPPEATVAITTAL-SKAGPAIPTPAVSSALA--VAVPLGPIM 898
               P    AAPA   ++  P AT + + AL S+A P +P    SS+L   +A PL    
Sbjct: 283 PQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP 342

Query: 899 AVTAAPAMVATL 910
              +AP  + TL
Sbjct: 343 PSPSAPPSLQTL 354



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 77/325 (23%), Positives = 106/325 (32%), Gaps = 73/325 (22%)

Query: 650 GKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGS 709
           G A+      APG   P  PG    PP                     P  P  +R +G+
Sbjct: 11  GAAARTPAARAPGLLTPRPPGSPRPPP---------------------PVTPAALRVLGA 49

Query: 710 SVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPAS 769
           +         E  G             ES PR + P  +  + +    S+ P       +
Sbjct: 50  AGAVGRKPLAERAG-----GIGGATIPESAPR-AGPTRSAGTSSRNPASRPPASGRGERA 103

Query: 770 PCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKA--ASAMDAVSRGPGREAP-------- 819
           P A N   T   P ++S   +SG +      QK    SA + V+RG   EAP        
Sbjct: 104 PPAKN---TSPGP-VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAG 159

Query: 820 ------------PLPTVARTEEAVG-RVGC---ADSRLLSPACPAP-KEVTAA------- 855
                       P P +AR   A G  VG    A S    P    P K V++A       
Sbjct: 160 ARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTE 219

Query: 856 --PAVAVPPEATVAI----TTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVAT 909
             PA    P A   +    + +LS +   + +PA S   A   P  P       P  +  
Sbjct: 220 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQA 279

Query: 910 L--GTVTKDGKTDAPPEGAALNGPV 932
           L    VT   K  AP  G   + P+
Sbjct: 280 LRPPQVTPPRKDAAPALGPLSSSPL 304


>gi|210032509 hypothetical protein LOC100130302 [Homo sapiens]
          Length = 887

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 45/193 (23%), Positives = 71/193 (36%), Gaps = 10/193 (5%)

Query: 720 EEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEK-AFSPASPCAWNVCVT 778
           ++  W  F D    C        +    ++   +  S+ +GP K + S + P + +   +
Sbjct: 378 QKSPWQPFPDDHSACLRPGSETDAGRAVSQAQESVQSKVKGPGKMSHSSSGPASVSQLSS 437

Query: 779 RKAP------LLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVG 832
            K P       + S  S  G  H     Q  +S+    S   G   PP    +  +    
Sbjct: 438 WKTPEQPDPVWVQSSVSGKGEKHPPPRTQLPSSSGKISS---GNSFPPQQAGSPLKRPFS 494

Query: 833 RVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAV 892
                 +   + A  A     AAPA A+   A  A+  A + A  A   PA + A A AV
Sbjct: 495 AAAAIAAAAAAAAAAAAAAAAAAPAPALAAAAAPALAAAAAPALAAAAAPAPAPAAAPAV 554

Query: 893 PLGPIMAVTAAPA 905
              P  A +AAP+
Sbjct: 555 AAAPAAAASAAPS 567



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 40/129 (31%), Positives = 54/129 (41%), Gaps = 6/129 (4%)

Query: 803 AASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPP 862
           AA+A  A +      A P P +A    A      A   L + A PAP    AAPAVA  P
Sbjct: 501 AAAAAAAAAAAAAAAAAPAPALAAAA-APALAAAAAPALAAAAAPAPAPA-AAPAVAAAP 558

Query: 863 EATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAM-VATLGTVTKDGKTDA 921
            A  +   + S+  P++P    S     A P  P   +  APA+ + T  T  K    + 
Sbjct: 559 AAAASAAPSHSQK-PSVPLIQASRPCPAAQP--PTKFIKIAPAIQLRTGSTGLKAINVEG 615

Query: 922 PPEGAALNG 930
           P +GA   G
Sbjct: 616 PVQGAQALG 624


>gi|33946327 nucleoporin 214kDa [Homo sapiens]
          Length = 2090

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 76/294 (25%), Positives = 100/294 (34%), Gaps = 48/294 (16%)

Query: 665  APPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGV----VRDVGSS--VWAAGTSA 718
            APP  GK   PPV   +  A  T+V    A ST +        V   GSS  +   GTS 
Sbjct: 1376 APPVLGKHTEPPV---TSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSL 1432

Query: 719  PEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVT 778
               K    F   Q    + + P  + P  T  +    S    P  +F      A    + 
Sbjct: 1433 SAGKTSFSFGSQQ---TNSTVPPSAPPPTTAATPLPTS---FPTLSFGSLLSSATTPSLP 1486

Query: 779  RKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVAR---------TEE 829
              A     +++SS         + +ASA   +      + P  P              + 
Sbjct: 1487 MSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQP 1546

Query: 830  AVGRVGCADS-----RLLSPACPAPKEVTAAPAVAVPPEA-------TVAITTALSKAGP 877
            AV   G A S      L + A PA   V  A   AVPP +       T     A+S AGP
Sbjct: 1547 AVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGP 1606

Query: 878  AI----PTPAVSSALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAA 927
                   TP  SS  ++  P GP        A  A  GTVT      A P  A+
Sbjct: 1607 VAVETSSTPIASSTTSIVAP-GP-------SAEAAAFGTVTSGSSVFAQPPAAS 1652



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 39/165 (23%), Positives = 63/165 (38%), Gaps = 25/165 (15%)

Query: 788  SSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVART---------------EEAVG 832
            S S+G +    G Q+  S +   +  P   A PLPT   T                 + G
Sbjct: 1431 SLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAG 1490

Query: 833  RVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAI------TTALSKAGPAIPTPAVSS 886
            R     +    P  P   EV+A+ A  +  + +  +      T+   K  P +  PAVS+
Sbjct: 1491 RSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSN 1550

Query: 887  ALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALNGP 931
            +   A      +   +A A  AT G    D +T+A P  ++ + P
Sbjct: 1551 SGTAASSTS--LVALSAEATPATTG--VPDARTEAVPPASSFSVP 1591


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 82/324 (25%), Positives = 118/324 (36%), Gaps = 57/324 (17%)

Query: 634  ASESCSKNGP----ERGGQDGKASLEAHRDAPGAGAPPAPGKKEA-PPVEGDSEGAMWTA 688
            A+   SK GP     + G    A+  +H+  P A  PP+P +  A P  +GD        
Sbjct: 1351 ATTPSSKGGPTTPSSKEGPTPPAATPSHKGGP-AMTPPSPKRGPAIPSPKGDPTSPAVIP 1409

Query: 689  VFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDT 748
            +  + A +TP    V R+ G++  + G   P                 + GP   S    
Sbjct: 1410 LSPKKAPATP----VTRE-GAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPS---- 1460

Query: 749  ECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMD 808
                ++G  +       SP  P A     T  +P  A  + +  G          A  + 
Sbjct: 1461 ----SKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMG----------APTLP 1506

Query: 809  AVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLS---PACPAPKEVTAAPAVAVP-PEA 864
            AV     +E P  P+  R   A        + LLS   PA  APKE    PA+ VP P+ 
Sbjct: 1507 AVIPSSPKEVPATPSSRRDPIA------PTATLLSKKTPATLAPKEALIPPAMTVPSPKK 1560

Query: 865  TVAITTALSKAGPAIPT-------PAVSSALAVAVP-----LGPIMAVTAAPAMVATLGT 912
            T AI T   K  PA P+       PAV+ +     P     L P    + +P    T   
Sbjct: 1561 TPAIPT--PKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPA 1618

Query: 913  VT----KDGKTDAPPEGAALNGPV 932
            VT    + G     P+G   + PV
Sbjct: 1619 VTPPSPEKGPATPAPKGTPTSPPV 1642



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 80/317 (25%), Positives = 101/317 (31%), Gaps = 41/317 (12%)

Query: 632  PHASESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPP----VEGDSEGAMWT 687
            P A+    K GP      G  +  A       G P  P  K AP          +G+   
Sbjct: 966  PAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAA 1025

Query: 688  AVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSS--- 744
              F + A++ P A         S   +  + P  KG A  T        + GP   S   
Sbjct: 1026 TPFPKGASTPPAA------TPPSPKGSPAATPLPKG-APTTPAATLPSPKGGPATPSLKG 1078

Query: 745  ----PVDTECSHAEGSRSQGPE-----KAFSPASPCAWNVCVTRK-APLL-ASDSSSSGG 793
                P  T  S   G  +  P+      A +P SP         K AP   A+   S  G
Sbjct: 1079 APTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKG 1138

Query: 794  SHSEDGDQKAASAMDAVSRGP-GREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEV 852
              +    + A +   A    P G  A P P  A T  A        S     A P+PK  
Sbjct: 1139 GLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPA----ATPPSPKGGLATPSPKGA 1194

Query: 853  TAAPAVAVPPEATVAITTALSKAGPAIPT---PAVSSALAVAVPLGPIMAVTAAPAMVAT 909
               PA A PP     + T   K  P  P    P+    LA   P G       AP   A 
Sbjct: 1195 PTTPA-ATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKG-------APTTPAA 1246

Query: 910  LGTVTKDGKTDAPPEGA 926
                 K G    PP+GA
Sbjct: 1247 TPPSPKGGPATPPPKGA 1263



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 40/139 (28%), Positives = 50/139 (35%), Gaps = 21/139 (15%)

Query: 802  KAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVP 861
            K A    AV+    +  P LP  A T  + G           P  P+ KE    PA    
Sbjct: 1330 KGAPTPPAVTPPSPKGTPTLP--ATTPSSKG----------GPTTPSSKEGPTPPAATPS 1377

Query: 862  PEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMA----VTAAPAMVATLGTVTKDG 917
             +   A+T    K GPAIP+P         +PL P  A    VT   A   + G +T   
Sbjct: 1378 HKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPA 1437

Query: 918  KT-----DAPPEGAALNGP 931
             T      AP   A   GP
Sbjct: 1438 VTPVSLKKAPATSAPKGGP 1456



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 64/284 (22%), Positives = 90/284 (31%), Gaps = 49/284 (17%)

Query: 627  PRFGAPH---ASESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAP-GKKEAPPVEGDSE 682
            P  GAP+    +    K GP      G  +       P A  PP+P G    PP +G   
Sbjct: 1282 PHKGAPNPAVVTPPSPKGGPATSPPKGAPT-------PPAATPPSPKGSPGTPPPKGAPT 1334

Query: 683  GAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRC 742
                 AV       TPT P             G + P  K         P    + GP  
Sbjct: 1335 PP---AVTPPSPKGTPTLPATTPSS-----KGGPTTPSSKEGPTPPAATP--SHKGGPAM 1384

Query: 743  SSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQK 802
            + P           +      A  P SP        +KAP  A+  +  G +    GD  
Sbjct: 1385 TPPSPKRGPAIPSPKGDPTSPAVIPLSP--------KKAP--ATPVTREGAATPSKGDLT 1434

Query: 803  AASAMD-AVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVP 861
              +    ++ + P   AP       + +        D  L +   P+PKE         P
Sbjct: 1435 PPAVTPVSLKKAPATSAPKGGPATPSSKG-------DPTLPAVTPPSPKE---------P 1478

Query: 862  PEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPA 905
            P      T++  K  PA P P  +  L   +P  P   V A P+
Sbjct: 1479 PAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSP-KEVPATPS 1521



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 67/281 (23%), Positives = 89/281 (31%), Gaps = 36/281 (12%)

Query: 661  PGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPT---APGVVRDVGSSVWAAGTS 717
            P A  P +P     PP E  +   +    F +   +TP    AP +     S   A  T 
Sbjct: 867  PSAVTPLSPKGVTLPPKETPTPSVV-NLPFPKEGPATPAPKQAPALSMTSSSPKKARATP 925

Query: 718  APEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEK-AFSPASPCAWNVC 776
            AP      K     P       P  ++P   +   A  S    P   A +P SP      
Sbjct: 926  AP------KGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPAT 979

Query: 777  VTRKA---PLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAP---PLPTVARTEEA 830
             + K    P  A+  S  GG  +     K A    AV+    + +P   P P  A T  A
Sbjct: 980  PSPKGAPTPPAATPPSPKGGPATPS--PKGAPTPPAVTPPSPKGSPAATPFPKGASTPPA 1037

Query: 831  VGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAV 890
                            P+PK   AA  +      T A T    K GPA P+   +     
Sbjct: 1038 A-------------TPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPA 1084

Query: 891  AVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALNGP 931
            A P  P       PA  +  G       T   P+G     P
Sbjct: 1085 ATPPSP----KGGPATPSPKGAPMPPAATPPSPKGGLATPP 1121


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 51/201 (25%), Positives = 75/201 (37%), Gaps = 22/201 (10%)

Query: 736  SESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSH 795
            S+S  +CS   D++  +   S S+    + S +S  + +          +S SSSS  S 
Sbjct: 1011 SDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSS---------SSSSSSSSESS 1061

Query: 796  SEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVT-- 853
            SED +++   A    +  P RE  P+PT A  E     V   +    SP  P P++    
Sbjct: 1062 SEDEEEEERPAALPSASPPPREV-PVPTPAPVE-----VPVPERVAGSPVTPLPEQEASP 1115

Query: 854  ---AAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVATL 910
               A P    PP A   +      AGP  P P      +  +PL P           + +
Sbjct: 1116 ARPAGPTEESPPSA--PLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAI 1173

Query: 911  GTVTKDGKTDAPPEGAALNGP 931
              V       A P  A   GP
Sbjct: 1174 EVVPAPEPPPATPPQAKFPGP 1194


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 37/118 (31%), Positives = 40/118 (33%), Gaps = 10/118 (8%)

Query: 814 PGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALS 873
           P R A P P   R          A +   +PA P P    AA A A  P A  A  TA  
Sbjct: 102 PRRGATP-PAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPP 160

Query: 874 KAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALNGP 931
             GPA P P    A  +A P          PA  A        G   APP   A   P
Sbjct: 161 SPGPAQPGPRAQRAAPLAAP---------PPAPAAPPAVAPPAGPRRAPPPAVAAREP 209



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 49/184 (26%), Positives = 64/184 (34%), Gaps = 41/184 (22%)

Query: 751 SHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAV 810
           S+   +R Q P +  +P +P        R AP  A+ ++              A+A  A 
Sbjct: 92  SYRNAARVQPPRRGATPPAPPR----APRGAPAAAAAAAPPPTPAPPPPPAPVAAA--AP 145

Query: 811 SRGP-----GREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEAT 865
           +R P        APP P                     PA P P+   AAP +A PP A 
Sbjct: 146 ARAPRAAAAAATAPPSP--------------------GPAQPGPRAQRAAP-LAAPPPAP 184

Query: 866 VAITTALSKAGP-AIPTPAVSSALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPE 924
            A       AGP   P PAV+   A   PL P     A P             +   PPE
Sbjct: 185 AAPPAVAPPAGPRRAPPPAVA---AREPPLPPPPQPPAPPQQ-----QQPPPPQPQPPPE 236

Query: 925 GAAL 928
           G A+
Sbjct: 237 GGAV 240


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 82/330 (24%), Positives = 111/330 (33%), Gaps = 61/330 (18%)

Query: 630 GAPHASESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPGKKE-APPVEGDSEGAMWTA 688
           G     ES  + GP R    G +S         A  PPA G+ E APP +  S G     
Sbjct: 66  GGATIPESAPRAGPTRSA--GTSSRNP------ASRPPASGRGERAPPAKNTSPG----- 112

Query: 689 VFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESG--------- 739
               P +S   A G  R           SA E     K T+        +G         
Sbjct: 113 ----PVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 168

Query: 740 PRCSSPVDTECSHAEGSR---------------SQGPEKAFSPASPCAWNVCVTRKAPLL 784
           P   SP     S A G+                ++GP K+ S AS  +     T  +P  
Sbjct: 169 PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS----TTEPSPAA 224

Query: 785 ASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSP 844
               S+ GG         ++SA    S  P R  P      R      +      + L P
Sbjct: 225 RRRPSAGGGLQRPASRSLSSSATPLSS--PARSGPSARGTPRAPAHPSQPKPKGLQALRP 282

Query: 845 ACPAPKEVTAAPAVAVPPEATVAI-TTALSKAGP-------AIPTPAV---SSALAVAVP 893
               P    AAPA+     + +A  + + +KA P       A P PA    S  LA  +P
Sbjct: 283 PQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLP 342

Query: 894 LGPIMAVTAAPAMVATLGTVTKDGKTDAPP 923
           L P     +AP  + TL +      + APP
Sbjct: 343 LAP--PSPSAPPSLQTLPSPPATPPSQAPP 370



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 4/79 (5%)

Query: 821 LPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPA--VAVPPEATVAITTALSKAGPA 878
           LP++A               L +P CPAP  + A P+     PPE   +I T   +A PA
Sbjct: 538 LPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPA 597

Query: 879 IPTPAVSSALAVAVPLGPI 897
           + +P +      + PL P+
Sbjct: 598 LASPPLQG--LPSPPLSPL 614



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 62/312 (19%), Positives = 108/312 (34%), Gaps = 42/312 (13%)

Query: 616 DTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDAPGAGAP-PAPGKKEA 674
           +T    +    P+  A  A      +GP  G      +  +       G P PAP  +  
Sbjct: 140 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 199

Query: 675 PPVEGDSEGAMWTAVFD--EPANSTPTAP----GVVRDVGSSVWAAGT--SAPEEKGWAK 726
           PP EG  +     +     EP+ +    P    G+ R    S+ ++ T  S+P   G + 
Sbjct: 200 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS- 258

Query: 727 FTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLAS 786
                    +   PR  +P        +G ++  P +   P    A  +     +PL A+
Sbjct: 259 ---------ARGTPR--APAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL-AT 306

Query: 787 DSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPAC 846
            S S   +        AA+ + A        A PLP                    SP+ 
Sbjct: 307 PSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPP----------------SPSA 350

Query: 847 PAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPT-PAVSSALAVAVPLGPIMAVTAAPA 905
           P   +   +P    P +A  ++TT   +A P++ T P +    ++     P +    +P 
Sbjct: 351 PPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLT---SPSLQAPPSPL 407

Query: 906 MVATLGTVTKDG 917
            +++L   T  G
Sbjct: 408 ALSSLQATTSLG 419



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 77/325 (23%), Positives = 106/325 (32%), Gaps = 73/325 (22%)

Query: 650 GKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGS 709
           G A+      APG   P  PG    PP                     P  P  +R +G+
Sbjct: 11  GAAARTPAARAPGLLTPRPPGSPRPPP---------------------PVTPAALRVLGA 49

Query: 710 SVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPAS 769
           +         E  G             ES PR + P  +  + +    S+ P       +
Sbjct: 50  AGAVGRKPLAERAG-----GIGGATIPESAPR-AGPTRSAGTSSRNPASRPPASGRGERA 103

Query: 770 PCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKA--ASAMDAVSRGPGREAP-------- 819
           P A N   T   P ++S   +SG +      QK    SA + V+RG   EAP        
Sbjct: 104 PPAKN---TSPGP-VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAG 159

Query: 820 ------------PLPTVARTEEAVG-RVGC---ADSRLLSPACPAP-KEVTAA------- 855
                       P P +AR   A G  VG    A S    P    P K V++A       
Sbjct: 160 ARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTE 219

Query: 856 --PAVAVPPEATVAI----TTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVAT 909
             PA    P A   +    + +LS +   + +PA S   A   P  P       P  +  
Sbjct: 220 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQA 279

Query: 910 L--GTVTKDGKTDAPPEGAALNGPV 932
           L    VT   K  AP  G   + P+
Sbjct: 280 LRPPQVTPPRKDAAPALGPLSSSPL 304


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 41.2 bits (95), Expect = 0.005
 Identities = 74/283 (26%), Positives = 95/283 (33%), Gaps = 31/283 (10%)

Query: 661 PGAGAPPAPGKKEAPPVEGDSE-GAMWTAVFDEPANSTPTAPGVVRDVGSSV-----WAA 714
           P A A  APG    PP  G +  G         P+   P  P       + +      +A
Sbjct: 75  PAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSA 134

Query: 715 GTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWN 774
           G+ AP     A     +P     + P   + +        G    GP     P  P    
Sbjct: 135 GSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGP-GPGPGPGPGPGKPAGPG 193

Query: 775 VCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAP-PLP----TVARTEE 829
              T       + S++   SH       AA A+  V+ GP    P P P    TV +T  
Sbjct: 194 AAQT------LNGSAALLNSH-----HAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPP 242

Query: 830 AVGRVGC-ADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSAL 888
            VG     A +    PA PAP    AAPA A PP      T A     PA P P  + A+
Sbjct: 243 FVGAAAPPAPAAPSPPAAPAP----AAPAAAPPPPPPAPATLARPPGHPAGP-PTAAPAV 297

Query: 889 AVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALNGP 931
                     +  AAPA     G     G +  P  GAA   P
Sbjct: 298 PPPAAAQNGGSAGAAPAPAPAAGGPA--GVSGQPGPGAAAAAP 338



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 77/304 (25%), Positives = 100/304 (32%), Gaps = 42/304 (13%)

Query: 627 PRFGAPHASESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMW 686
           P   A  A    +  GP +    G A+L A R  PG G  P PG    P        A  
Sbjct: 141 PAAAAVAAGPEPAPAGPAKPA--GPAALAA-RAGPGPGPGPGPGPGPGPGKPAGPGAAQT 197

Query: 687 TAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPV 746
                   NS   A   V  V +   AA    P+           PF  + + P  ++P 
Sbjct: 198 LNGSAALLNSHHAAAPAVSLVNNGP-AALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAP- 255

Query: 747 DTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASA 806
                         P  A +PA+P A         P  A+ +   G          A   
Sbjct: 256 -------------SPPAAPAPAAPAA---APPPPPPAPATLARPPGHPAGPPTAAPAVPP 299

Query: 807 MDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATV 866
             A   G    A P P  A    A G  G +         P P    AAPA  V  E+  
Sbjct: 300 PAAAQNGGSAGAAPAPAPA----AGGPAGVSGQ-------PGPGAAAAAPAPGVKAESPK 348

Query: 867 AITTALSKAGPAIPTPAVS--SALAVAVPLGPIM-AVTAAPAMVATLGTVTKDGKTDAPP 923
            +  A   A PA  T A S  ++ A ++ +GP M     +PA V      T  G     P
Sbjct: 349 RVVQA---APPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGL----P 401

Query: 924 EGAA 927
           +GAA
Sbjct: 402 KGAA 405



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 49/177 (27%), Positives = 62/177 (35%), Gaps = 25/177 (14%)

Query: 780 KAPLLASDSSSSGGSHSEDGDQKAASAMD--AVSRGPGREAPPLPTVARTEEAVG---RV 834
           + P + + ++ + G+H   G    A+     A + G    AP  P   R     G   R 
Sbjct: 46  RTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRP 105

Query: 835 GCADSRL-LSPACPAPK--------EVTAAPAVAVPPEATVAITTALSKAGPAIPT-PAV 884
           G    R  L PA PAP         E +A     VP  A VA     + AGPA P  PA 
Sbjct: 106 GPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAA 165

Query: 885 SSALAVAVP-------LGPIMAVTAAPAMVATL---GTVTKDGKTDAPPEGAALNGP 931
            +A A   P        GP     A P    TL     +       AP      NGP
Sbjct: 166 LAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGP 222


>gi|209862845 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 4 isoform 1 [Homo sapiens]
          Length = 964

 Score = 40.8 bits (94), Expect = 0.006
 Identities = 67/286 (23%), Positives = 105/286 (36%), Gaps = 39/286 (13%)

Query: 652 ASLEAHRDAPGAGAPPAPGKKEAPPVEG-----DSEGAMWTAVFD-EPANSTPTAPGVVR 705
           A+LE + DA G G+P     ++ PP EG     ++ G    A F   P +S+ ++     
Sbjct: 192 AALEDNPDAWGDGSP-----RDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFS 246

Query: 706 DVG--SSVWAAGTSAPEEKGWA--KFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGP 761
           D    ++++AA      E   A  +F    P     + PR  +P D    +      +GP
Sbjct: 247 DASDEAALYAACDEVESELNEAASRFGLGSPLPSPRASPRPWTPEDPWSLYGPSPGGRGP 306

Query: 762 EKAF-------------SPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMD 808
           E ++              PASPC      +   P  AS + S  GS  E+G +       
Sbjct: 307 EDSWLLLSAPGPTPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGSEPPPPPPL 366

Query: 809 AVSRGPGRE-------APPLPTV-ARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAV 860
            ++R PG         APP  ++  +T         A  R   PA    K    A     
Sbjct: 367 PLARDPGSPGPFDYVGAPPAESIPQKTRRTSSEQAVALPRSEEPASCNGKLPLGAEESVA 426

Query: 861 PPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAM 906
           PP  +      +     A+P+P   S   +     PI   +A P +
Sbjct: 427 PPGGSRKEVAGMDYL--AVPSPLAWSKARIG-GHSPIFRTSALPPL 469


>gi|27886563 nuclear factor of activated T-cells, cytoplasmic,
           calcineurin-dependent 4 isoform 2 [Homo sapiens]
          Length = 902

 Score = 40.8 bits (94), Expect = 0.006
 Identities = 67/286 (23%), Positives = 105/286 (36%), Gaps = 39/286 (13%)

Query: 652 ASLEAHRDAPGAGAPPAPGKKEAPPVEG-----DSEGAMWTAVFD-EPANSTPTAPGVVR 705
           A+LE + DA G G+P     ++ PP EG     ++ G    A F   P +S+ ++     
Sbjct: 129 AALEDNPDAWGDGSP-----RDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFS 183

Query: 706 DVG--SSVWAAGTSAPEEKGWA--KFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGP 761
           D    ++++AA      E   A  +F    P     + PR  +P D    +      +GP
Sbjct: 184 DASDEAALYAACDEVESELNEAASRFGLGSPLPSPRASPRPWTPEDPWSLYGPSPGGRGP 243

Query: 762 EKAF-------------SPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMD 808
           E ++              PASPC      +   P  AS + S  GS  E+G +       
Sbjct: 244 EDSWLLLSAPGPTPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGSEPPPPPPL 303

Query: 809 AVSRGPGRE-------APPLPTV-ARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAV 860
            ++R PG         APP  ++  +T         A  R   PA    K    A     
Sbjct: 304 PLARDPGSPGPFDYVGAPPAESIPQKTRRTSSEQAVALPRSEEPASCNGKLPLGAEESVA 363

Query: 861 PPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAM 906
           PP  +      +     A+P+P   S   +     PI   +A P +
Sbjct: 364 PPGGSRKEVAGMDYL--AVPSPLAWSKARIG-GHSPIFRTSALPPL 406


>gi|117938759 GNAS complex locus XLas [Homo sapiens]
          Length = 1037

 Score = 40.4 bits (93), Expect = 0.008
 Identities = 72/286 (25%), Positives = 98/286 (34%), Gaps = 33/286 (11%)

Query: 652 ASLEAHRDAPGAGAPP--APGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGS 709
           A+  A R  P A APP   PG   +P  E              P+N T          GS
Sbjct: 259 AASSAVRLTPAANAPPLWVPGAIGSPSQEA----------VRPPSNFT----------GS 298

Query: 710 SVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQG---PEKAFS 766
           S W   +  P E G A           +S P        + S A   R +    P +  +
Sbjct: 299 SPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEA 358

Query: 767 PASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVAR 826
                A +     K P     S ++G + ++   + A +A      G   E P   T   
Sbjct: 359 AEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPA 418

Query: 827 TEEAVGRVGCADSRLLSPACPAPKEVTAAP-AVAVP-----PEATVAITTALSKAGPAIP 880
             ++       DS   +PA PA  +  AAP A A P     P+A        +   PA P
Sbjct: 419 DPDSGAFAADPDSGA-APAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAP 477

Query: 881 TPAVSSALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGA 926
             A + A  VA P  P      APA  AT     +   + AP  GA
Sbjct: 478 AAAETRAAHVA-PAAPDAGAPTAPAASATRAAQVRRAASAAPASGA 522


>gi|239745807 PREDICTED: keratin associated protein 4-9 [Homo
           sapiens]
          Length = 254

 Score = 40.4 bits (93), Expect = 0.008
 Identities = 59/216 (27%), Positives = 77/216 (35%), Gaps = 20/216 (9%)

Query: 651 KASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRD--VG 708
           K S+     AP A  PPA G   A P       A  +A     AN    AP  VR    G
Sbjct: 11  KTSVRRPAAAPAAVRPPAAGPPAAAPAVVYPAAAGPSAASLCAANPLVPAPAAVRPPVAG 70

Query: 709 SSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPA 768
               A     P   G            S +  R ++P+    + A   R      A SPA
Sbjct: 71  PPATAPAVVCPAAAG-----------PSAASLRAANPL--AVAPAAVRRPAATLGAASPA 117

Query: 769 SPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTE 828
           +     VC    +P  AS  ++S  + +      AA+A  AV+  P   AP    V    
Sbjct: 118 AVAPAAVCPAAASPSAASLCAASPTAAAPAAASPAAAAPLAVN--PAAAAPAAACVQSVA 175

Query: 829 EAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEA 864
           E+          + SPA PAP    A P +A  P A
Sbjct: 176 ESPATPLAIAQPVSSPAAPAP---CAVPPLAAEPTA 208



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 46/196 (23%), Positives = 71/196 (36%), Gaps = 9/196 (4%)

Query: 660 APGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTS-- 717
           AP A  PP  G     P       A  +A     AN    AP  VR   +++ AA  +  
Sbjct: 60  APAAVRPPVAGPPATAPAVVCPAAAGPSAASLRAANPLAVAPAAVRRPAATLGAASPAAV 119

Query: 718 APEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFSPASPCAWNVCV 777
           AP     A  +      C+ S P  ++P     S A  +       A +PA+ C  +V  
Sbjct: 120 APAAVCPAAASPSAASLCAAS-PTAAAP--AAASPAAAAPLAVNPAAAAPAAACVQSVAE 176

Query: 778 TRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAP----PLPTVARTEEAVGR 833
           +   PL  +   SS  + +       A+   A++  P    P    P   +    + VG 
Sbjct: 177 SPATPLAIAQPVSSPAAPAPCAVPPLAAEPTALAYLPLHHWPTDVDPSTVLTIRIQEVGL 236

Query: 834 VGCADSRLLSPACPAP 849
           +      L+ P  P+P
Sbjct: 237 MSFNRMELMFPMSPSP 252



 Score = 30.8 bits (68), Expect = 6.1
 Identities = 32/115 (27%), Positives = 43/115 (37%), Gaps = 18/115 (15%)

Query: 816 REAPPLPTV-ARTEEAVGRVGCADSRLLSPA--CPAPKEVTAAPAVAVPPEATVAITTAL 872
           R A PL    A        +G A    ++PA  CPA    +AA   A  P A        
Sbjct: 92  RAANPLAVAPAAVRRPAATLGAASPAAVAPAAVCPAAASPSAASLCAASPTA-------- 143

Query: 873 SKAGPAIPTPAVSSALAV----AVPLGP-IMAVTAAPAMVATLGTVTKDGKTDAP 922
             A PA  +PA ++ LAV    A P    + +V  +PA    +          AP
Sbjct: 144 --AAPAAASPAAAAPLAVNPAAAAPAAACVQSVAESPATPLAIAQPVSSPAAPAP 196



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 31/133 (23%), Positives = 49/133 (36%), Gaps = 10/133 (7%)

Query: 803 AASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPAC--------PAPKEVTA 854
           A +A+   + GP   AP +   A    +   +  A+  + +PA         PA      
Sbjct: 20  APAAVRPPAAGPPAAAPAVVYPAAAGPSAASLCAANPLVPAPAAVRPPVAGPPATAPAVV 79

Query: 855 APAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVATLGTVT 914
            PA A P  A++     L+ A  A+  PA  + L  A P     A     A   +  ++ 
Sbjct: 80  CPAAAGPSAASLRAANPLAVAPAAVRRPA--ATLGAASPAAVAPAAVCPAAASPSAASLC 137

Query: 915 KDGKTDAPPEGAA 927
               T A P  A+
Sbjct: 138 AASPTAAAPAAAS 150


>gi|30795231 brain abundant, membrane attached signal protein 1
           [Homo sapiens]
          Length = 227

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 44/147 (29%), Positives = 61/147 (41%), Gaps = 16/147 (10%)

Query: 787 DSSSSGGSHSEDGDQKAA---SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLS 843
           D  + G +  E+G  K +   +A +      G+E P      + EE  G    A ++  +
Sbjct: 23  DKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEA 82

Query: 844 PACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAA 903
           P     K   AA A A PP+A      A    GPA    A  +A A A P     A +AA
Sbjct: 83  PKAEPEKTEGAAEAKAEPPKAPEQEQAA---PGPAAGGEAPKAAEAAAAP-----AESAA 134

Query: 904 PAMVATLGTVTKDG---KTDAPPEGAA 927
           PA  A      ++G   KT+AP   AA
Sbjct: 135 PA--AGEEPSKEEGEPKKTEAPAAPAA 159


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 69/296 (23%), Positives = 96/296 (32%), Gaps = 47/296 (15%)

Query: 644 ERGGQDGKASLEAHRDAPGAGA-----PPAPGKKE-APPVEGDSEGAMWTAVFDEPANST 697
           ER G  G A++     AP AG      PPA G+ E APP +  S G         P +S 
Sbjct: 60  ERAGGIGGATIP--ESAPRAGPTRTSRPPASGRGERAPPAKNTSPG---------PVSSP 108

Query: 698 PTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESG---------PRCSSPVDT 748
             A G  R           SA E     K T+        +G         P   SP   
Sbjct: 109 GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 168

Query: 749 ECSHAEGSR---------------SQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGG 793
             S A G+                ++GP K+ S AS  +     T  +P      S+ GG
Sbjct: 169 RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS----TTEPSPAARRRPSAGGG 224

Query: 794 SHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVT 853
                    ++SA    S  P R  P      R      +      + L P    P    
Sbjct: 225 LQRPASRSLSSSATPLSS--PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD 282

Query: 854 AAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVAT 909
           AAPA+     + +A  +  +   P+ P    +     A P         +P + AT
Sbjct: 283 AAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT 338



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 71/311 (22%), Positives = 102/311 (32%), Gaps = 54/311 (17%)

Query: 650 GKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGS 709
           G A+      APG   P  PG    PP                     P  P  +R +G+
Sbjct: 11  GAAARTPAARAPGLLTPRPPGSPRPPP---------------------PVTPAALRVLGA 49

Query: 710 SVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSS--PVDTECSHAEGSRSQGPEKAFSP 767
           +  A G     E+         P     +GP  +S  P       A  +++  P    SP
Sbjct: 50  A-GAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSP 108

Query: 768 ASPCAWNVCVTRKAPL------LASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPL 821
                     TR  PL      ++++ + + G  +E   + A SA             P 
Sbjct: 109 GRASG----TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 164

Query: 822 PTVARTEEAVG-RVGC---ADSRLLSPACPAP-KEVTAA---------PAVAVPPEATVA 867
           P +AR   A G  VG    A S    P    P K V++A         PA    P A   
Sbjct: 165 PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGG 224

Query: 868 I----TTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVATL--GTVTKDGKTDA 921
           +    + +LS +   + +PA S   A   P  P       P  +  L    VT   K  A
Sbjct: 225 LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 284

Query: 922 PPEGAALNGPV 932
           P  G   + P+
Sbjct: 285 PALGPLSSSPL 295


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 58/272 (21%), Positives = 95/272 (34%), Gaps = 25/272 (9%)

Query: 635 SESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPG---------KKEAPPVEGDSEGAM 685
           SES  ++      ++  A++ A +  P    P               +  PV   ++   
Sbjct: 531 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 590

Query: 686 WTAVFDEPANSTPT-APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSS 744
                  PA S+P  A G  R    S  +  + + EEK     T  Q     +       
Sbjct: 591 KAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG-----L 645

Query: 745 PVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAA 804
            V       +GS  QG     +P  P      VT+       DS SS      D ++ AA
Sbjct: 646 QVKAASVPVKGSLGQGT----APVLPGKTGPTVTQVKAEKQEDSESS--EEESDSEEAAA 699

Query: 805 SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEA 864
           S     +     +A   P  AR   A G +  A  ++++ A  A +    +P+   PP  
Sbjct: 700 SPAQVKTSVKKTQAKANPAAARAPSAKGTIS-APGKVVTAAAQAKQR---SPSKVKPPVR 755

Query: 865 TVAITTALSKAGPAIPTPAVSSALAVAVPLGP 896
               +T L++   ++P+   + A A     GP
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGP 787



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 67/304 (22%), Positives = 109/304 (35%), Gaps = 31/304 (10%)

Query: 651 KASLEAHRDAPGAGAPPAPGKK--------EAPPVEGDSEGAMWTAVFDEPANSTPTAPG 702
           +A+    +  PG GA PAP  K        +A   E DSE +  +    +    TP A  
Sbjct: 224 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS--SEESSDSEEETPAAKA 281

Query: 703 VV--RDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGP---RCSSPVDTECSHAEGSR 757
           ++  +  G +      SAP ++   K     P    ++GP   +  +    E S +    
Sbjct: 282 LLQAKASGKTSQVGAASAPAKESPRK--GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 339

Query: 758 SQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGRE 817
           S   E+A + A P +      R A   A +S   G + +       A+A   V +     
Sbjct: 340 SDSEEEAPAQAKP-SGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDS 398

Query: 818 APPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGP 877
                      EA+  +  A  + L  +     +V  A  + + P    A      K GP
Sbjct: 399 RSSSEESDSDREALAAMNAAQVKPLGKS----PQVKPASTMGMGPLGKGAGPVPPGKVGP 454

Query: 878 AIPTPAV--------SSALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALN 929
           A P+  V        SS+   +      +    APA   +LG + +   T +P +G    
Sbjct: 455 ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 514

Query: 930 -GPV 932
            GPV
Sbjct: 515 AGPV 518



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 42/142 (29%), Positives = 54/142 (38%), Gaps = 31/142 (21%)

Query: 757  RSQGPEKAFSPASPCAWNVCVTRKAPLLASDS-----SSSGGSHSEDGDQKAASAMDAVS 811
            +++G  K   P  P    V    KAP  + DS     SSSG     +G Q A SA   V 
Sbjct: 1041 QAKGTNKLRKPKLP---EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVG 1097

Query: 812  RGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTA 871
                      PT +RTE  V       S           +V A     +    T  +T A
Sbjct: 1098 ----------PTPSRTETLVEETAAESSE---------DDVVAPSQSLLSGYMTPGLTPA 1138

Query: 872  LSKAGPAIP----TPAVSSALA 889
             S+A  A P    +P+VSS LA
Sbjct: 1139 NSQASKATPKLDSSPSVSSTLA 1160



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 71/288 (24%), Positives = 95/288 (32%), Gaps = 46/288 (15%)

Query: 648 QDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVR-- 705
           +D ++S E   D+     P A     AP  E      +       PA   P   G V   
Sbjct: 466 EDSESSSEESSDSSDGEVPTAV----APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 521

Query: 706 -------DVGSSVWAAGTSAPEEKGWAKFTDFQ--PFCCSESGPRCSSPVDTECSHAEGS 756
                  D   S   +  SA  E+  A  T  Q  P         C    +T  S     
Sbjct: 522 VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP 581

Query: 757 ---RSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDG-------------- 799
               +Q P KA +  SP   +  V       A DSSSS  S SE+               
Sbjct: 582 VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 641

Query: 800 ----DQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAA 855
                 KAAS     S G G  AP LP   +T   V +V    +     +  + +E  + 
Sbjct: 642 GKGLQVKAASVPVKGSLGQG-TAPVLP--GKTGPTVTQV---KAEKQEDSESSEEESDSE 695

Query: 856 PAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAA 903
            A A P +   ++    +KA PA    A  +  A      P   VTAA
Sbjct: 696 EAAASPAQVKTSVKKTQAKANPA----AARAPSAKGTISAPGKVVTAA 739



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 57/273 (20%), Positives = 89/273 (32%), Gaps = 36/273 (13%)

Query: 647 GQDGKASLEAHRDAPGAGAPPAPGKKEAPPV-------EGDSEGAMWTAVFDEPANSTPT 699
           G   KA+    + + G G  P    K  P V       + DSE +   +  +E A S   
Sbjct: 644 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 703

Query: 700 APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQ 759
               V+   +    A   AP  KG            +++  R  S V     + + S   
Sbjct: 704 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763

Query: 760 GPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSE-DGDQKA--------------- 803
               A  PAS  +    V   A         SG S  E D +++A               
Sbjct: 764 ----ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 819

Query: 804 ----ASAMDAVSRG-----PGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTA 854
               A A ++  +G     PG+  P      + +++      +DS   +PA     +V  
Sbjct: 820 RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 879

Query: 855 APAVAVPPEATVAITTALSKAGPAIPTPAVSSA 887
            P + V P  + A   A      A  TP  + A
Sbjct: 880 PPLIFVDPNRSPAGPAATPAQAQAASTPRKARA 912


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 58/272 (21%), Positives = 95/272 (34%), Gaps = 25/272 (9%)

Query: 635 SESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPG---------KKEAPPVEGDSEGAM 685
           SES  ++      ++  A++ A +  P    P               +  PV   ++   
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 686 WTAVFDEPANSTPT-APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSS 744
                  PA S+P  A G  R    S  +  + + EEK     T  Q     +       
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG-----L 722

Query: 745 PVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAA 804
            V       +GS  QG     +P  P      VT+       DS SS      D ++ AA
Sbjct: 723 QVKAASVPVKGSLGQGT----APVLPGKTGPTVTQVKAEKQEDSESS--EEESDSEEAAA 776

Query: 805 SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEA 864
           S     +     +A   P  AR   A G +  A  ++++ A  A +    +P+   PP  
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTIS-APGKVVTAAAQAKQR---SPSKVKPPVR 832

Query: 865 TVAITTALSKAGPAIPTPAVSSALAVAVPLGP 896
               +T L++   ++P+   + A A     GP
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGP 864



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 71/340 (20%), Positives = 111/340 (32%), Gaps = 60/340 (17%)

Query: 643 PERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPG 702
           PE   +  +   E+  +AP          ++   V   S  A  T        +TP  PG
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP----GKGATPAPPG 321

Query: 703 VVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSH-------AEG 755
               V S   A       E    + +D +     E  P   + +  + S        A  
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESSDSE-----EETPAAKALLQAKASGKTSQVGAASA 376

Query: 756 SRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDA------ 809
              + P K  +PA P      V +       + S S    S+  ++  A A  +      
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436

Query: 810 -VSRGPGREAP-----PLPTVARTEEAVGRVGCA----DSRLLSPACPAPKEVTAAPAVA 859
             +  P +E+P     P P   +T  A  +V       DSR  S    + +E  AA   A
Sbjct: 437 RAASAPAKESPRKGAAPAPP-RKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAA 495

Query: 860 ----------VPPEATVAI--------TTALSKAGPAIPTPAV--------SSALAVAVP 893
                     V P +T+ +             K GPA P+  V        SS+   +  
Sbjct: 496 QVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDS 555

Query: 894 LGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALN-GPV 932
               +    APA   +LG + +   T +P +G     GPV
Sbjct: 556 SDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 42/142 (29%), Positives = 54/142 (38%), Gaps = 31/142 (21%)

Query: 757  RSQGPEKAFSPASPCAWNVCVTRKAPLLASDS-----SSSGGSHSEDGDQKAASAMDAVS 811
            +++G  K   P  P    V    KAP  + DS     SSSG     +G Q A SA   V 
Sbjct: 1080 QAKGTNKLRKPKLP---EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVG 1136

Query: 812  RGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTA 871
                      PT +RTE  V       S           +V A     +    T  +T A
Sbjct: 1137 ----------PTPSRTETLVEETAAESSE---------DDVVAPSQSLLSGYMTPGLTPA 1177

Query: 872  LSKAGPAIP----TPAVSSALA 889
             S+A  A P    +P+VSS LA
Sbjct: 1178 NSQASKATPKLDSSPSVSSTLA 1199



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 71/288 (24%), Positives = 95/288 (32%), Gaps = 46/288 (15%)

Query: 648 QDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVR-- 705
           +D ++S E   D+     P A     AP  E      +       PA   P   G V   
Sbjct: 543 EDSESSSEESSDSSDGEVPTAV----APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 598

Query: 706 -------DVGSSVWAAGTSAPEEKGWAKFTDFQ--PFCCSESGPRCSSPVDTECSHAEGS 756
                  D   S   +  SA  E+  A  T  Q  P         C    +T  S     
Sbjct: 599 VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP 658

Query: 757 ---RSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDG-------------- 799
               +Q P KA +  SP   +  V       A DSSSS  S SE+               
Sbjct: 659 VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 718

Query: 800 ----DQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAA 855
                 KAAS     S G G  AP LP   +T   V +V    +     +  + +E  + 
Sbjct: 719 GKGLQVKAASVPVKGSLGQG-TAPVLP--GKTGPTVTQV---KAEKQEDSESSEEESDSE 772

Query: 856 PAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAA 903
            A A P +   ++    +KA PA    A  +  A      P   VTAA
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPA----AARAPSAKGTISAPGKVVTAA 816



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 57/273 (20%), Positives = 89/273 (32%), Gaps = 36/273 (13%)

Query: 647 GQDGKASLEAHRDAPGAGAPPAPGKKEAPPV-------EGDSEGAMWTAVFDEPANSTPT 699
           G   KA+    + + G G  P    K  P V       + DSE +   +  +E A S   
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 700 APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQ 759
               V+   +    A   AP  KG            +++  R  S V     + + S   
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840

Query: 760 GPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSE-DGDQKA--------------- 803
               A  PAS  +    V   A         SG S  E D +++A               
Sbjct: 841 ----ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 896

Query: 804 ----ASAMDAVSRG-----PGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTA 854
               A A ++  +G     PG+  P      + +++      +DS   +PA     +V  
Sbjct: 897 RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956

Query: 855 APAVAVPPEATVAITTALSKAGPAIPTPAVSSA 887
            P + V P  + A   A      A  TP  + A
Sbjct: 957 PPLIFVDPNRSPAGPAATPAQAQAASTPRKARA 989


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 58/272 (21%), Positives = 95/272 (34%), Gaps = 25/272 (9%)

Query: 635 SESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPG---------KKEAPPVEGDSEGAM 685
           SES  ++      ++  A++ A +  P    P               +  PV   ++   
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 686 WTAVFDEPANSTPT-APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSS 744
                  PA S+P  A G  R    S  +  + + EEK     T  Q     +       
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG-----L 722

Query: 745 PVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAA 804
            V       +GS  QG     +P  P      VT+       DS SS      D ++ AA
Sbjct: 723 QVKAASVPVKGSLGQGT----APVLPGKTGPTVTQVKAEKQEDSESS--EEESDSEEAAA 776

Query: 805 SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEA 864
           S     +     +A   P  AR   A G +  A  ++++ A  A +    +P+   PP  
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTIS-APGKVVTAAAQAKQR---SPSKVKPPVR 832

Query: 865 TVAITTALSKAGPAIPTPAVSSALAVAVPLGP 896
               +T L++   ++P+   + A A     GP
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGP 864



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 71/340 (20%), Positives = 111/340 (32%), Gaps = 60/340 (17%)

Query: 643 PERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPG 702
           PE   +  +   E+  +AP          ++   V   S  A  T        +TP  PG
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP----GKGATPAPPG 321

Query: 703 VVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSH-------AEG 755
               V S   A       E    + +D +     E  P   + +  + S        A  
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESSDSE-----EETPAAKALLQAKASGKTSQVGAASA 376

Query: 756 SRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDA------ 809
              + P K  +PA P      V +       + S S    S+  ++  A A  +      
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436

Query: 810 -VSRGPGREAP-----PLPTVARTEEAVGRVGCA----DSRLLSPACPAPKEVTAAPAVA 859
             +  P +E+P     P P   +T  A  +V       DSR  S    + +E  AA   A
Sbjct: 437 RAASAPAKESPRKGAAPAPP-RKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAA 495

Query: 860 ----------VPPEATVAI--------TTALSKAGPAIPTPAV--------SSALAVAVP 893
                     V P +T+ +             K GPA P+  V        SS+   +  
Sbjct: 496 QVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDS 555

Query: 894 LGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALN-GPV 932
               +    APA   +LG + +   T +P +G     GPV
Sbjct: 556 SDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 71/288 (24%), Positives = 95/288 (32%), Gaps = 46/288 (15%)

Query: 648 QDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVR-- 705
           +D ++S E   D+     P A     AP  E      +       PA   P   G V   
Sbjct: 543 EDSESSSEESSDSSDGEVPTAV----APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 598

Query: 706 -------DVGSSVWAAGTSAPEEKGWAKFTDFQ--PFCCSESGPRCSSPVDTECSHAEGS 756
                  D   S   +  SA  E+  A  T  Q  P         C    +T  S     
Sbjct: 599 VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP 658

Query: 757 ---RSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDG-------------- 799
               +Q P KA +  SP   +  V       A DSSSS  S SE+               
Sbjct: 659 VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 718

Query: 800 ----DQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAA 855
                 KAAS     S G G  AP LP   +T   V +V    +     +  + +E  + 
Sbjct: 719 GKGLQVKAASVPVKGSLGQG-TAPVLP--GKTGPTVTQV---KAEKQEDSESSEEESDSE 772

Query: 856 PAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAA 903
            A A P +   ++    +KA PA    A  +  A      P   VTAA
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPA----AARAPSAKGTISAPGKVVTAA 816



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 57/273 (20%), Positives = 89/273 (32%), Gaps = 36/273 (13%)

Query: 647 GQDGKASLEAHRDAPGAGAPPAPGKKEAPPV-------EGDSEGAMWTAVFDEPANSTPT 699
           G   KA+    + + G G  P    K  P V       + DSE +   +  +E A S   
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 700 APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQ 759
               V+   +    A   AP  KG            +++  R  S V     + + S   
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840

Query: 760 GPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSE-DGDQKA--------------- 803
               A  PAS  +    V   A         SG S  E D +++A               
Sbjct: 841 ----ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 896

Query: 804 ----ASAMDAVSRG-----PGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTA 854
               A A ++  +G     PG+  P      + +++      +DS   +PA     +V  
Sbjct: 897 RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956

Query: 855 APAVAVPPEATVAITTALSKAGPAIPTPAVSSA 887
            P + V P  + A   A      A  TP  + A
Sbjct: 957 PPLIFVDPNRSPAGPAATPAQAQAASTPRKARA 989


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 58/272 (21%), Positives = 95/272 (34%), Gaps = 25/272 (9%)

Query: 635 SESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPG---------KKEAPPVEGDSEGAM 685
           SES  ++      ++  A++ A +  P    P               +  PV   ++   
Sbjct: 531 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 590

Query: 686 WTAVFDEPANSTPT-APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSS 744
                  PA S+P  A G  R    S  +  + + EEK     T  Q     +       
Sbjct: 591 KAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG-----L 645

Query: 745 PVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAA 804
            V       +GS  QG     +P  P      VT+       DS SS      D ++ AA
Sbjct: 646 QVKAASVPVKGSLGQGT----APVLPGKTGPTVTQVKAEKQEDSESS--EEESDSEEAAA 699

Query: 805 SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEA 864
           S     +     +A   P  AR   A G +  A  ++++ A  A +    +P+   PP  
Sbjct: 700 SPAQVKTSVKKTQAKANPAAARAPSAKGTIS-APGKVVTAAAQAKQR---SPSKVKPPVR 755

Query: 865 TVAITTALSKAGPAIPTPAVSSALAVAVPLGP 896
               +T L++   ++P+   + A A     GP
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGP 787



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 67/304 (22%), Positives = 109/304 (35%), Gaps = 31/304 (10%)

Query: 651 KASLEAHRDAPGAGAPPAPGKK--------EAPPVEGDSEGAMWTAVFDEPANSTPTAPG 702
           +A+    +  PG GA PAP  K        +A   E DSE +  +    +    TP A  
Sbjct: 224 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS--SEESSDSEEETPAAKA 281

Query: 703 VV--RDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGP---RCSSPVDTECSHAEGSR 757
           ++  +  G +      SAP ++   K     P    ++GP   +  +    E S +    
Sbjct: 282 LLQAKASGKTSQVGAASAPAKESPRK--GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 339

Query: 758 SQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGRE 817
           S   E+A + A P +      R A   A +S   G + +       A+A   V +     
Sbjct: 340 SDSEEEAPAQAKP-SGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDS 398

Query: 818 APPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGP 877
                      EA+  +  A  + L  +     +V  A  + + P    A      K GP
Sbjct: 399 RSSSEESDSDREALAAMNAAQVKPLGKS----PQVKPASTMGMGPLGKGAGPVPPGKVGP 454

Query: 878 AIPTPAV--------SSALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALN 929
           A P+  V        SS+   +      +    APA   +LG + +   T +P +G    
Sbjct: 455 ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 514

Query: 930 -GPV 932
            GPV
Sbjct: 515 AGPV 518



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 71/288 (24%), Positives = 95/288 (32%), Gaps = 46/288 (15%)

Query: 648 QDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVR-- 705
           +D ++S E   D+     P A     AP  E      +       PA   P   G V   
Sbjct: 466 EDSESSSEESSDSSDGEVPTAV----APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 521

Query: 706 -------DVGSSVWAAGTSAPEEKGWAKFTDFQ--PFCCSESGPRCSSPVDTECSHAEGS 756
                  D   S   +  SA  E+  A  T  Q  P         C    +T  S     
Sbjct: 522 VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP 581

Query: 757 ---RSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDG-------------- 799
               +Q P KA +  SP   +  V       A DSSSS  S SE+               
Sbjct: 582 VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 641

Query: 800 ----DQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAA 855
                 KAAS     S G G  AP LP   +T   V +V    +     +  + +E  + 
Sbjct: 642 GKGLQVKAASVPVKGSLGQG-TAPVLP--GKTGPTVTQV---KAEKQEDSESSEEESDSE 695

Query: 856 PAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAA 903
            A A P +   ++    +KA PA    A  +  A      P   VTAA
Sbjct: 696 EAAASPAQVKTSVKKTQAKANPA----AARAPSAKGTISAPGKVVTAA 739



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 57/273 (20%), Positives = 89/273 (32%), Gaps = 36/273 (13%)

Query: 647 GQDGKASLEAHRDAPGAGAPPAPGKKEAPPV-------EGDSEGAMWTAVFDEPANSTPT 699
           G   KA+    + + G G  P    K  P V       + DSE +   +  +E A S   
Sbjct: 644 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 703

Query: 700 APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQ 759
               V+   +    A   AP  KG            +++  R  S V     + + S   
Sbjct: 704 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763

Query: 760 GPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSE-DGDQKA--------------- 803
               A  PAS  +    V   A         SG S  E D +++A               
Sbjct: 764 ----ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 819

Query: 804 ----ASAMDAVSRG-----PGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTA 854
               A A ++  +G     PG+  P      + +++      +DS   +PA     +V  
Sbjct: 820 RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 879

Query: 855 APAVAVPPEATVAITTALSKAGPAIPTPAVSSA 887
            P + V P  + A   A      A  TP  + A
Sbjct: 880 PPLIFVDPNRSPAGPAATPAQAQAASTPRKARA 912


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 58/272 (21%), Positives = 95/272 (34%), Gaps = 25/272 (9%)

Query: 635 SESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPG---------KKEAPPVEGDSEGAM 685
           SES  ++      ++  A++ A +  P    P               +  PV   ++   
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 686 WTAVFDEPANSTPT-APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSS 744
                  PA S+P  A G  R    S  +  + + EEK     T  Q     +       
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG-----L 722

Query: 745 PVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAA 804
            V       +GS  QG     +P  P      VT+       DS SS      D ++ AA
Sbjct: 723 QVKAASVPVKGSLGQGT----APVLPGKTGPTVTQVKAEKQEDSESS--EEESDSEEAAA 776

Query: 805 SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEA 864
           S     +     +A   P  AR   A G +  A  ++++ A  A +    +P+   PP  
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTIS-APGKVVTAAAQAKQR---SPSKVKPPVR 832

Query: 865 TVAITTALSKAGPAIPTPAVSSALAVAVPLGP 896
               +T L++   ++P+   + A A     GP
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGP 864



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 71/340 (20%), Positives = 111/340 (32%), Gaps = 60/340 (17%)

Query: 643 PERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPG 702
           PE   +  +   E+  +AP          ++   V   S  A  T        +TP  PG
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP----GKGATPAPPG 321

Query: 703 VVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSH-------AEG 755
               V S   A       E    + +D +     E  P   + +  + S        A  
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESSDSE-----EETPAAKALLQAKASGKTSQVGAASA 376

Query: 756 SRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDA------ 809
              + P K  +PA P      V +       + S S    S+  ++  A A  +      
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436

Query: 810 -VSRGPGREAP-----PLPTVARTEEAVGRVGCA----DSRLLSPACPAPKEVTAAPAVA 859
             +  P +E+P     P P   +T  A  +V       DSR  S    + +E  AA   A
Sbjct: 437 RAASAPAKESPRKGAAPAPP-RKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAA 495

Query: 860 ----------VPPEATVAI--------TTALSKAGPAIPTPAV--------SSALAVAVP 893
                     V P +T+ +             K GPA P+  V        SS+   +  
Sbjct: 496 QVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDS 555

Query: 894 LGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALN-GPV 932
               +    APA   +LG + +   T +P +G     GPV
Sbjct: 556 SDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 71/288 (24%), Positives = 95/288 (32%), Gaps = 46/288 (15%)

Query: 648 QDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVR-- 705
           +D ++S E   D+     P A     AP  E      +       PA   P   G V   
Sbjct: 543 EDSESSSEESSDSSDGEVPTAV----APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 598

Query: 706 -------DVGSSVWAAGTSAPEEKGWAKFTDFQ--PFCCSESGPRCSSPVDTECSHAEGS 756
                  D   S   +  SA  E+  A  T  Q  P         C    +T  S     
Sbjct: 599 VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP 658

Query: 757 ---RSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDG-------------- 799
               +Q P KA +  SP   +  V       A DSSSS  S SE+               
Sbjct: 659 VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 718

Query: 800 ----DQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAA 855
                 KAAS     S G G  AP LP   +T   V +V    +     +  + +E  + 
Sbjct: 719 GKGLQVKAASVPVKGSLGQG-TAPVLP--GKTGPTVTQV---KAEKQEDSESSEEESDSE 772

Query: 856 PAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAA 903
            A A P +   ++    +KA PA    A  +  A      P   VTAA
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPA----AARAPSAKGTISAPGKVVTAA 816



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 57/273 (20%), Positives = 89/273 (32%), Gaps = 36/273 (13%)

Query: 647 GQDGKASLEAHRDAPGAGAPPAPGKKEAPPV-------EGDSEGAMWTAVFDEPANSTPT 699
           G   KA+    + + G G  P    K  P V       + DSE +   +  +E A S   
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 700 APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQ 759
               V+   +    A   AP  KG            +++  R  S V     + + S   
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840

Query: 760 GPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSE-DGDQKA--------------- 803
               A  PAS  +    V   A         SG S  E D +++A               
Sbjct: 841 ----ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 896

Query: 804 ----ASAMDAVSRG-----PGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTA 854
               A A ++  +G     PG+  P      + +++      +DS   +PA     +V  
Sbjct: 897 RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956

Query: 855 APAVAVPPEATVAITTALSKAGPAIPTPAVSSA 887
            P + V P  + A   A      A  TP  + A
Sbjct: 957 PPLIFVDPNRSPAGPAATPAQAQAASTPRKARA 989


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 58/272 (21%), Positives = 95/272 (34%), Gaps = 25/272 (9%)

Query: 635 SESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPG---------KKEAPPVEGDSEGAM 685
           SES  ++      ++  A++ A +  P    P               +  PV   ++   
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 686 WTAVFDEPANSTPT-APGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSS 744
                  PA S+P  A G  R    S  +  + + EEK     T  Q     +       
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG-----L 722

Query: 745 PVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAA 804
            V       +GS  QG     +P  P      VT+       DS SS      D ++ AA
Sbjct: 723 QVKAASVPVKGSLGQGT----APVLPGKTGPTVTQVKAEKQEDSESS--EEESDSEEAAA 776

Query: 805 SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEA 864
           S     +     +A   P  AR   A G +  A  ++++ A  A +    +P+   PP  
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTIS-APGKVVTAAAQAKQR---SPSKVKPPVR 832

Query: 865 TVAITTALSKAGPAIPTPAVSSALAVAVPLGP 896
               +T L++   ++P+   + A A     GP
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGP 864



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 71/340 (20%), Positives = 111/340 (32%), Gaps = 60/340 (17%)

Query: 643 PERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPG 702
           PE   +  +   E+  +AP          ++   V   S  A  T        +TP  PG
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP----GKGATPAPPG 321

Query: 703 VVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSH-------AEG 755
               V S   A       E    + +D +     E  P   + +  + S        A  
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESSDSE-----EETPAAKALLQAKASGKTSQVGAASA 376

Query: 756 SRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDA------ 809
              + P K  +PA P      V +       + S S    S+  ++  A A  +      
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436

Query: 810 -VSRGPGREAP-----PLPTVARTEEAVGRVGCA----DSRLLSPACPAPKEVTAAPAVA 859
             +  P +E+P     P P   +T  A  +V       DSR  S    + +E  AA   A
Sbjct: 437 RAASAPAKESPRKGAAPAPP-RKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAA 495

Query: 860 ----------VPPEATVAI--------TTALSKAGPAIPTPAV--------SSALAVAVP 893
                     V P +T+ +             K GPA P+  V        SS+   +  
Sbjct: 496 QVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDS 555

Query: 894 LGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALN-GPV 932
               +    APA   +LG + +   T +P +G     GPV
Sbjct: 556 SDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 71/288 (24%), Positives = 95/288 (32%), Gaps = 46/288 (15%)

Query: 648 QDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVR-- 705
           +D ++S E   D+     P A     AP  E      +       PA   P   G V   
Sbjct: 543 EDSESSSEESSDSSDGEVPTAV----APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 598

Query: 706 -------DVGSSVWAAGTSAPEEKGWAKFTDFQ--PFCCSESGPRCSSPVDTECSHAEGS 756
                  D   S   +  SA  E+  A  T  Q  P         C    +T  S     
Sbjct: 599 VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP 658

Query: 757 ---RSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDG-------------- 799
               +Q P KA +  SP   +  V       A DSSSS  S SE+               
Sbjct: 659 VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 718

Query: 800 ----DQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAA 855
                 KAAS     S G G  AP LP   +T   V +V    +     +  + +E  + 
Sbjct: 719 GKGLQVKAASVPVKGSLGQG-TAPVLP--GKTGPTVTQV---KAEKQEDSESSEEESDSE 772

Query: 856 PAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAA 903
            A A P +   ++    +KA PA    A  +  A      P   VTAA
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPA----AARAPSAKGTISAPGKVVTAA 816


>gi|222418647 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 50/191 (26%), Positives = 69/191 (36%), Gaps = 19/191 (9%)

Query: 745 PVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAA 804
           P  +  + A  S S  PE   +P +P A     T +AP     SS+   + +      A 
Sbjct: 170 PTPSATTPAPPSSSAPPETTAAPPTPSA-----TTQAP---PSSSAPPETTAAPPTPPAT 221

Query: 805 SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVA-VPPE 863
           +     S  P       PT + T  A             P  P P   T  P+ A  PPE
Sbjct: 222 TPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVP--PTPSATTLDPSSASAPPE 279

Query: 864 ATVAITT--ALSKAGPAIPTPAVSSALAVAVP------LGPIMAVTAAPAMVATLGTVTK 915
            T A  T  A + A P+ P P  ++A  +  P      L P  + T+A     T  +VT 
Sbjct: 280 TTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTT 339

Query: 916 DGKTDAPPEGA 926
              T   P  A
Sbjct: 340 QTTTTKQPTSA 350



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 58/207 (28%), Positives = 83/207 (40%), Gaps = 51/207 (24%)

Query: 687 TAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPV 746
           TA    P+ +TP  P              +SAP E   A  T   P   +++ P  S+P 
Sbjct: 166 TAAPPTPSATTPAPPS-------------SSAPPETTAAPPT---PSATTQAPPSSSAPP 209

Query: 747 DTECSH--------AEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSED 798
           +T  +         A  S S  PE   +P +P A     T  APL    SSS+    +  
Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSA-----TTPAPL----SSSAPPETTAV 260

Query: 799 GDQKAASAMD--AVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAP 856
               +A+ +D  + S  P   A P PT + T  A             P+ PAP+E TAAP
Sbjct: 261 PPTPSATTLDPSSASAPPETTAAP-PTPSATTPA------------PPSSPAPQETTAAP 307

Query: 857 AVAVPPEA--TVAITTALSKAGPAIPT 881
            +  P  +  T+A  T+ + A P   T
Sbjct: 308 -ITTPNSSPTTLAPDTSETSAAPTHQT 333



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 37/128 (28%), Positives = 47/128 (36%), Gaps = 22/128 (17%)

Query: 814 PGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAP-----AVAVPPEATVAI 868
           P   APP  T A    +        +    P+  AP E TAAP         PP ++   
Sbjct: 180 PSSSAPPETTAAPPTPSA-------TTQAPPSSSAPPETTAAPPTPPATTPAPPSSSAPP 232

Query: 869 TTALSKAGPAIPTPAVSSALA----VAVPLGPIMAVTAAPAMVA-----TLGTVTKDGKT 919
            T  +   P+  TPA  S+ A     AVP  P  A T  P+  +     T    T    T
Sbjct: 233 ETTAAPPTPSATTPAPLSSSAPPETTAVPPTP-SATTLDPSSASAPPETTAAPPTPSATT 291

Query: 920 DAPPEGAA 927
            APP   A
Sbjct: 292 PAPPSSPA 299


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
           sapiens]
          Length = 2524

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 60/260 (23%), Positives = 94/260 (36%), Gaps = 25/260 (9%)

Query: 631 APH--ASESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTA 688
           +PH  A++   +NGP+       A+L A  D P  G P  P +    P E         A
Sbjct: 753 SPHTEAAKDTGQNGPKP-----PATLGA--DGPPPGPPTPPPEDIPAPTEPTPASEATGA 805

Query: 689 VFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDT 748
               PA  +P+AP  V            + P E+G  +          ++G +   PV +
Sbjct: 806 PTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTG-KAEEPVKS 864

Query: 749 ECS-HAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAM 807
           EC+  AE   ++G +   + A+         ++     + ++ S G+  +D D  A  + 
Sbjct: 865 ECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGA-PQDSDSSATCSA 923

Query: 808 DAVSRGPG----REAPPLPTVARTEEAVGRVGCADSRL-LSPACPAPKEVTAAPAVAVPP 862
           D V    G    R   P P++             D R   SP  P   +     A A+PP
Sbjct: 924 DEVDEAEGGDKNRLLSPRPSLL--------TPTGDPRANASPQKPLDLKQLKQRAAAIPP 975

Query: 863 EATVAITTALSKAGPAIPTP 882
             T         A P  P P
Sbjct: 976 IVTKVHEPPREDAAPTKPAP 995


>gi|222418649 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 50/191 (26%), Positives = 69/191 (36%), Gaps = 19/191 (9%)

Query: 745 PVDTECSHAEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAA 804
           P  +  + A  S S  PE   +P +P A     T +AP     SS+   + +      A 
Sbjct: 170 PTPSATTPAPPSSSAPPETTAAPPTPSA-----TTQAP---PSSSAPPETTAAPPTPPAT 221

Query: 805 SAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVA-VPPE 863
           +     S  P       PT + T  A             P  P P   T  P+ A  PPE
Sbjct: 222 TPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVP--PTPSATTLDPSSASAPPE 279

Query: 864 ATVAITT--ALSKAGPAIPTPAVSSALAVAVP------LGPIMAVTAAPAMVATLGTVTK 915
            T A  T  A + A P+ P P  ++A  +  P      L P  + T+A     T  +VT 
Sbjct: 280 TTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTT 339

Query: 916 DGKTDAPPEGA 926
              T   P  A
Sbjct: 340 QTTTTKQPTSA 350



 Score = 38.1 bits (87), Expect = 0.038
 Identities = 58/207 (28%), Positives = 83/207 (40%), Gaps = 51/207 (24%)

Query: 687 TAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPV 746
           TA    P+ +TP  P              +SAP E   A  T   P   +++ P  S+P 
Sbjct: 166 TAAPPTPSATTPAPPS-------------SSAPPETTAAPPT---PSATTQAPPSSSAPP 209

Query: 747 DTECSH--------AEGSRSQGPEKAFSPASPCAWNVCVTRKAPLLASDSSSSGGSHSED 798
           +T  +         A  S S  PE   +P +P A     T  APL    SSS+    +  
Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSA-----TTPAPL----SSSAPPETTAV 260

Query: 799 GDQKAASAMD--AVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAP 856
               +A+ +D  + S  P   A P PT + T  A             P+ PAP+E TAAP
Sbjct: 261 PPTPSATTLDPSSASAPPETTAAP-PTPSATTPA------------PPSSPAPQETTAAP 307

Query: 857 AVAVPPEA--TVAITTALSKAGPAIPT 881
            +  P  +  T+A  T+ + A P   T
Sbjct: 308 -ITTPNSSPTTLAPDTSETSAAPTHQT 333



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 37/128 (28%), Positives = 47/128 (36%), Gaps = 22/128 (17%)

Query: 814 PGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAP-----AVAVPPEATVAI 868
           P   APP  T A    +        +    P+  AP E TAAP         PP ++   
Sbjct: 180 PSSSAPPETTAAPPTPSA-------TTQAPPSSSAPPETTAAPPTPPATTPAPPSSSAPP 232

Query: 869 TTALSKAGPAIPTPAVSSALA----VAVPLGPIMAVTAAPAMVA-----TLGTVTKDGKT 919
            T  +   P+  TPA  S+ A     AVP  P  A T  P+  +     T    T    T
Sbjct: 233 ETTAAPPTPSATTPAPLSSSAPPETTAVPPTP-SATTLDPSSASAPPETTAAPPTPSATT 291

Query: 920 DAPPEGAA 927
            APP   A
Sbjct: 292 PAPPSSPA 299


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,890,857
Number of Sequences: 37866
Number of extensions: 2037242
Number of successful extensions: 10618
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 274
Number of HSP's that attempted gapping in prelim test: 9501
Number of HSP's gapped (non-prelim): 1083
length of query: 932
length of database: 18,247,518
effective HSP length: 112
effective length of query: 820
effective length of database: 14,006,526
effective search space: 11485351320
effective search space used: 11485351320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.