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Search of human proteins with 122937199
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937199 protein phosphatase 1B-like [Homo sapiens]
(430 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937199 protein phosphatase 1B-like [Homo sapiens] 865 0.0
gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens] 301 8e-82
gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens] 300 1e-81
gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens] 300 2e-81
gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens] 296 2e-80
gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens] 293 2e-79
gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens] 263 2e-70
gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens] 258 1e-68
gi|7661862 protein phosphatase 1F [Homo sapiens] 132 6e-31
gi|4505999 protein phosphatase 1G [Homo sapiens] 114 2e-25
gi|29826282 protein phosphatase 1G [Homo sapiens] 114 2e-25
gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens] 108 9e-24
gi|13540531 integrin-linked kinase-associated protein phosphatas... 105 6e-23
gi|30089948 protein phosphatase 1E [Homo sapiens] 102 7e-22
gi|4505997 protein phosphatase 1D [Homo sapiens] 96 5e-20
gi|167466276 protein phosphatase 1K (PP2C domain containing) [Ho... 84 2e-16
gi|29558099 protein phosphatase 1B isoform 3 [Homo sapiens] 72 1e-12
gi|171460932 protein phosphatase 1M isoform a [Homo sapiens] 62 1e-09
gi|45439339 pyruvate dehyrogenase phosphatase catalytic subunit ... 55 2e-07
gi|239985428 pyruvate dehyrogenase phosphatase catalytic subunit... 55 2e-07
gi|239985426 pyruvate dehyrogenase phosphatase catalytic subunit... 55 2e-07
gi|239985422 pyruvate dehyrogenase phosphatase catalytic subunit... 55 2e-07
gi|239985420 pyruvate dehyrogenase phosphatase catalytic subunit... 55 2e-07
gi|171460934 protein phosphatase 1M isoform b [Homo sapiens] 51 2e-06
gi|65506328 protein phosphatase 1J (PP2C domain containing) [Hom... 50 4e-06
gi|41349497 pyruvate dehydrogenase phosphatase isoenzyme 2 [Homo... 49 7e-06
gi|149944715 protein phosphatase 1H (PP2C domain containing) [Ho... 45 1e-04
gi|5174703 mitogen-activated protein kinase kinase kinase 7 inte... 38 0.016
gi|41281798 mitogen-activated protein kinase kinase kinase 7 int... 38 0.016
gi|164419758 bromodomain containing 2 [Homo sapiens] 37 0.045
>gi|122937199 protein phosphatase 1B-like [Homo sapiens]
Length = 430
Score = 865 bits (2235), Expect = 0.0
Identities = 430/430 (100%), Positives = 430/430 (100%)
Query: 1 MAVLARQLQRLLWTACKKKEREKEGREEEEEEEAGRRAPEGPRSLLTAPRRAQRPHGGAE 60
MAVLARQLQRLLWTACKKKEREKEGREEEEEEEAGRRAPEGPRSLLTAPRRAQRPHGGAE
Sbjct: 1 MAVLARQLQRLLWTACKKKEREKEGREEEEEEEAGRRAPEGPRSLLTAPRRAQRPHGGAE 60
Query: 61 ASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPG 120
ASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPG
Sbjct: 61 ASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPG 120
Query: 121 HVLQELGPEPSEPEGVREALRRAFLSADERLRSLWPRVETGGCTAVVLLVSPRFLYLAHC 180
HVLQELGPEPSEPEGVREALRRAFLSADERLRSLWPRVETGGCTAVVLLVSPRFLYLAHC
Sbjct: 121 HVLQELGPEPSEPEGVREALRRAFLSADERLRSLWPRVETGGCTAVVLLVSPRFLYLAHC 180
Query: 181 GDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKE 240
GDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKE
Sbjct: 181 GDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKE 240
Query: 241 APGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPE 300
APGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPE
Sbjct: 241 APGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPE 300
Query: 301 LLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAALGCRIAELCASAQK 360
LLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAALGCRIAELCASAQK
Sbjct: 301 LLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAALGCRIAELCASAQK 360
Query: 361 PPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQICQVSEECGEKGQDGAGKSNPT 420
PPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQICQVSEECGEKGQDGAGKSNPT
Sbjct: 361 PPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQICQVSEECGEKGQDGAGKSNPT 420
Query: 421 HLGSALDMEA 430
HLGSALDMEA
Sbjct: 421 HLGSALDMEA 430
>gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens]
Length = 380
Score = 301 bits (771), Expect = 8e-82
Identities = 166/368 (45%), Positives = 224/368 (60%), Gaps = 14/368 (3%)
Query: 56 HGGAEASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGA 115
H A GLR+G S+ QGWR MEDAH + +P W+ FAV DGH G+R A + +
Sbjct: 13 HNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCS 72
Query: 116 RHLPGHV-----LQELGPEPS----EPEGVREALRRAFLSADERLRS---LWPRVETGGC 163
HL H+ + G S E V+ +R FL DE +R+ L ++ G
Sbjct: 73 THLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGS 132
Query: 164 TAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRV 223
TAV +++SP+ +Y +CGDSRAVL R G V FST+DH+P PRE+ERI AGG++ +RV
Sbjct: 133 TAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRV 192
Query: 224 EGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGA 283
GSLAVSRALGD+ YK G+ P QLVS EPEV + R EDEF++LA DG+WD +S
Sbjct: 193 NGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNE 252
Query: 284 ALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELAL 343
L V SRL + E +C ++DTCL KGS DNM+ +LVCF AP+ S+EA++++ L
Sbjct: 253 ELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSEL 312
Query: 344 DAALGCRIAELC--ASAQKPPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQICQ 401
D L R+ E+ + + P L V R L++E+IP+LPPGGGL K VI VYS++
Sbjct: 313 DKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNP 372
Query: 402 VSEECGEK 409
E G+K
Sbjct: 373 HRESDGQK 380
>gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens]
Length = 479
Score = 300 bits (769), Expect = 1e-81
Identities = 168/378 (44%), Positives = 226/378 (59%), Gaps = 20/378 (5%)
Query: 56 HGGAEASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGA 115
H A GLR+G S+ QGWR MEDAH + +P W+ FAV DGH G+R A + +
Sbjct: 13 HNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCS 72
Query: 116 RHLPGHV-----LQELGPEPS----EPEGVREALRRAFLSADERLRS---LWPRVETGGC 163
HL H+ + G S E V+ +R FL DE +R+ L ++ G
Sbjct: 73 THLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGS 132
Query: 164 TAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRV 223
TAV +++SP+ +Y +CGDSRAVL R G V FST+DH+P PRE+ERI AGG++ +RV
Sbjct: 133 TAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRV 192
Query: 224 EGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGA 283
GSLAVSRALGD+ YK G+ P QLVS EPEV + R EDEF++LA DG+WD +S
Sbjct: 193 NGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNE 252
Query: 284 ALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELAL 343
L V SRL + E +C ++DTCL KGS DNM+ +LVCF AP+ S+EA++++ L
Sbjct: 253 ELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSEL 312
Query: 344 DAALGCRIAELC--ASAQKPPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQICQ 401
D L R+ E+ + + P L V R L++E+IP+LPPGGGL K VI VYS++
Sbjct: 313 DKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNP 372
Query: 402 ------VSEECGEKGQDG 413
S+E E G G
Sbjct: 373 HRESDGASDEAEESGSQG 390
>gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens]
Length = 387
Score = 300 bits (767), Expect = 2e-81
Identities = 166/369 (44%), Positives = 223/369 (60%), Gaps = 14/369 (3%)
Query: 56 HGGAEASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGA 115
H A GLR+G S+ QGWR MEDAH + +P W+ FAV DGH G+R A + +
Sbjct: 13 HNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCS 72
Query: 116 RHLPGHV-----LQELGPEPS----EPEGVREALRRAFLSADERLRS---LWPRVETGGC 163
HL H+ + G S E V+ +R FL DE +R+ L ++ G
Sbjct: 73 THLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGS 132
Query: 164 TAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRV 223
TAV +++SP+ +Y +CGDSRAVL R G V FST+DH+P PRE+ERI AGG++ +RV
Sbjct: 133 TAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRV 192
Query: 224 EGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGA 283
GSLAVSRALGD+ YK G+ P QLVS EPEV + R EDEF++LA DG+WD +S
Sbjct: 193 NGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNE 252
Query: 284 ALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELAL 343
L V SRL + E +C ++DTCL KGS DNM+ +LVCF AP+ S+EA++++ L
Sbjct: 253 ELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSEL 312
Query: 344 DAALGCRIAELC--ASAQKPPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQICQ 401
D L R+ E+ + + P L V R L++E+IP+LPPGGGL K VI VYS++
Sbjct: 313 DKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNP 372
Query: 402 VSEECGEKG 410
E G G
Sbjct: 373 HRESDGGAG 381
>gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens]
Length = 455
Score = 296 bits (758), Expect = 2e-80
Identities = 171/406 (42%), Positives = 232/406 (57%), Gaps = 26/406 (6%)
Query: 18 KKEREKEGREEEEEEEAG---RRAPEGPR------------SLLTAPRRAQRPHGGAEAS 62
K+E +K+G E E+ G +R E + + L P+ + H
Sbjct: 35 KREEKKKGGERRRNEKRGNQMKRMCERKKYETDLEDQDIMGAFLDKPKMEK--HNAQGQG 92
Query: 63 GGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPGHV 122
GLR+G S+ QGWR MEDAH + LP W+ FAV DGH G++ A++ HL H+
Sbjct: 93 NGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHI 152
Query: 123 L--QELGPEPSEP--EGVREALRRAFLSADERLRSLWPR---VETGGCTAVVLLVSPRFL 175
Q+ P E V+ +R FL DE +R + + + G TAV +L+SP+
Sbjct: 153 TNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHT 212
Query: 176 YLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGD 235
Y +CGDSR +L R V F T+DH+P P E+ERI AGG++ +RV GSLAVSRALGD
Sbjct: 213 YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGD 272
Query: 236 FTYKEAPGRPPELQLVSAEPEVAALARQAE-DEFMLLASDGVWDTVSGAALAGLVASRLR 294
F YK G+ P QLVS EPEV + R E D+F++LA DG+WD + L V SRL
Sbjct: 273 FDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLE 332
Query: 295 LGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAALGCRIAEL 354
+ E +C +++DTCL KGS DNM+ IL+CFP AP+ S EA+++E LD L CR+ E+
Sbjct: 333 VTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEI 392
Query: 355 C-ASAQKPPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQI 399
+ P L V RTLASE+IP LPPGG L K VI VY+++
Sbjct: 393 IKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRL 438
>gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens]
Length = 382
Score = 293 bits (751), Expect = 2e-79
Identities = 160/353 (45%), Positives = 212/353 (60%), Gaps = 9/353 (2%)
Query: 56 HGGAEASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGA 115
H GLR+G S+ QGWR MEDAH + LP W+ FAV DGH G++ A++
Sbjct: 13 HNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCC 72
Query: 116 RHLPGHVL--QELGPEPSEP--EGVREALRRAFLSADERLRSLWPR---VETGGCTAVVL 168
HL H+ Q+ P E V+ +R FL DE +R + + + G TAV +
Sbjct: 73 EHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGV 132
Query: 169 LVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLA 228
L+SP+ Y +CGDSR +L R V F T+DH+P P E+ERI AGG++ +RV GSLA
Sbjct: 133 LISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLA 192
Query: 229 VSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAE-DEFMLLASDGVWDTVSGAALAG 287
VSRALGDF YK G+ P QLVS EPEV + R E D+F++LA DG+WD + L
Sbjct: 193 VSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCD 252
Query: 288 LVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAAL 347
V SRL + E +C +++DTCL KGS DNM+ IL+CFP AP+ S EA+++E LD L
Sbjct: 253 FVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYL 312
Query: 348 GCRIAELC-ASAQKPPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQI 399
CR+ E+ + P L V RTLASE+IP LPPGG L K VI VY+++
Sbjct: 313 ECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRL 365
>gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens]
Length = 327
Score = 263 bits (672), Expect = 2e-70
Identities = 141/308 (45%), Positives = 189/308 (61%), Gaps = 12/308 (3%)
Query: 56 HGGAEASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGA 115
H A GLR+G S+ QGWR MEDAH + +P W+ FAV DGH G+R A + +
Sbjct: 13 HNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCS 72
Query: 116 RHLPGHV-----LQELGPEPS----EPEGVREALRRAFLSADERLRS---LWPRVETGGC 163
HL H+ + G S E V+ +R FL DE +R+ L ++ G
Sbjct: 73 THLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGS 132
Query: 164 TAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRV 223
TAV +++SP+ +Y +CGDSRAVL R G V FST+DH+P PRE+ERI AGG++ +RV
Sbjct: 133 TAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRV 192
Query: 224 EGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGA 283
GSLAVSRALGD+ YK G+ P QLVS EPEV + R EDEF++LA DG+WD +S
Sbjct: 193 NGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNE 252
Query: 284 ALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELAL 343
L V SRL + E +C ++DTCL KGS DNM+ +LVCF AP+ S+EA++++ L
Sbjct: 253 ELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSEL 312
Query: 344 DAALGCRI 351
D L R+
Sbjct: 313 DKHLESRV 320
>gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens]
Length = 324
Score = 258 bits (658), Expect = 1e-68
Identities = 137/304 (45%), Positives = 183/304 (60%), Gaps = 8/304 (2%)
Query: 56 HGGAEASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGA 115
H GLR+G S+ QGWR MEDAH + LP W+ FAV DGH G++ A++
Sbjct: 13 HNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCC 72
Query: 116 RHLPGHVL--QELGPEPSEP--EGVREALRRAFLSADERLRSLWPR---VETGGCTAVVL 168
HL H+ Q+ P E V+ +R FL DE +R + + + G TAV +
Sbjct: 73 EHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGV 132
Query: 169 LVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLA 228
L+SP+ Y +CGDSR +L R V F T+DH+P P E+ERI AGG++ +RV GSLA
Sbjct: 133 LISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLA 192
Query: 229 VSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAE-DEFMLLASDGVWDTVSGAALAG 287
VSRALGDF YK G+ P QLVS EPEV + R E D+F++LA DG+WD + L
Sbjct: 193 VSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCD 252
Query: 288 LVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAAL 347
V SRL + E +C +++DTCL KGS DNM+ IL+CFP AP+ S EA+++E LD L
Sbjct: 253 FVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYL 312
Query: 348 GCRI 351
CR+
Sbjct: 313 ECRV 316
>gi|7661862 protein phosphatase 1F [Homo sapiens]
Length = 454
Score = 132 bits (332), Expect = 6e-31
Identities = 115/332 (34%), Positives = 154/332 (46%), Gaps = 41/332 (12%)
Query: 20 EREKEGREEEEEEEAGRRAPEGPRSLLTAPRRAQR----------------PHGGAEASG 63
E K REEEEEEE + P +LL A AQ P +
Sbjct: 94 EFRKLPREEEEEEEDDDEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARASQR 153
Query: 64 GLRFGASAAQGWRARMEDAHCTWLSLPGL-----PPGWALFAVLDGHGGARAARFGARHL 118
A + R +MED H + S L P A FAV DGHGG AAR+ A H+
Sbjct: 154 QWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHV 213
Query: 119 PGHVLQELGPE-PSEPEGVREALRRAFLSADER-LRSLWPRVETGGCTAVVLLVSPRFLY 176
+ ++ PE P++PEG ALR AF D+ LR G T V L++ L+
Sbjct: 214 HTNAARQ--PELPTDPEG---ALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLH 268
Query: 177 LAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRR---RVEGSLAVSRAL 233
+A GDS+ +L + G V E HRP R E+ RI A GG + RV G+LAVSRA+
Sbjct: 269 VAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAI 328
Query: 234 GDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRL 293
GD K VS E + A+ A ++++LLA DG +D V + GLV S L
Sbjct: 329 GDVFQK---------PYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHL 379
Query: 294 RLGLAPELLCA-QLLDTCLCKGSLDNMTCILV 324
L A +L+ +GS DN+T ++V
Sbjct: 380 TRQQGSGLRVAEELVAAARERGSHDNITVMVV 411
>gi|4505999 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 114 bits (284), Expect = 2e-25
Identities = 71/188 (37%), Positives = 102/188 (54%), Gaps = 17/188 (9%)
Query: 162 GCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRR 221
G TAVV L+ + L +A+ GDSR V+S AG + DH+P E RI AGG +
Sbjct: 328 GTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD 387
Query: 222 -RVEGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTV 280
RV G L +SRA+GD YK PPE Q++SA P++ L + EFM++A DG+W+ +
Sbjct: 388 GRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVM 447
Query: 281 SGAALAGLVASRL-------RLGLAPELLCAQLLDTCLCKGS------LDNMTCILVCFP 327
S + + S++ L L ++ +LLD CL + DNMTCI++CF
Sbjct: 448 SSQEVVDFIQSKISQRDENGELRLLSSIV-EELLDQCLAPDTSGDGTGCDNMTCIIICF- 505
Query: 328 GAPRPSEE 335
PR + E
Sbjct: 506 -KPRNTAE 512
Score = 58.5 bits (140), Expect = 1e-08
Identities = 34/87 (39%), Positives = 50/87 (57%), Gaps = 6/87 (6%)
Query: 65 LRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQ 124
L +G SA QGWR MEDAH +P L A+F+V DGHGG A + A++LP +
Sbjct: 25 LPYGFSAMQGWRVSMEDAHNC---IPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKD 81
Query: 125 ELGPEPSEPEGVREALRRAFLSADERL 151
+ + + +++AL AFL+ D +L
Sbjct: 82 QKAYKEGK---LQKALEDAFLAIDAKL 105
>gi|29826282 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 114 bits (284), Expect = 2e-25
Identities = 71/188 (37%), Positives = 102/188 (54%), Gaps = 17/188 (9%)
Query: 162 GCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRR 221
G TAVV L+ + L +A+ GDSR V+S AG + DH+P E RI AGG +
Sbjct: 328 GTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMD 387
Query: 222 -RVEGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTV 280
RV G L +SRA+GD YK PPE Q++SA P++ L + EFM++A DG+W+ +
Sbjct: 388 GRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVM 447
Query: 281 SGAALAGLVASRL-------RLGLAPELLCAQLLDTCLCKGS------LDNMTCILVCFP 327
S + + S++ L L ++ +LLD CL + DNMTCI++CF
Sbjct: 448 SSQEVVDFIQSKISQRDENGELRLLSSIV-EELLDQCLAPDTSGDGTGCDNMTCIIICF- 505
Query: 328 GAPRPSEE 335
PR + E
Sbjct: 506 -KPRNTAE 512
Score = 58.5 bits (140), Expect = 1e-08
Identities = 34/87 (39%), Positives = 50/87 (57%), Gaps = 6/87 (6%)
Query: 65 LRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQ 124
L +G SA QGWR MEDAH +P L A+F+V DGHGG A + A++LP +
Sbjct: 25 LPYGFSAMQGWRVSMEDAHNC---IPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKD 81
Query: 125 ELGPEPSEPEGVREALRRAFLSADERL 151
+ + + +++AL AFL+ D +L
Sbjct: 82 QKAYKEGK---LQKALEDAFLAIDAKL 105
>gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens]
Length = 360
Score = 108 bits (270), Expect = 9e-24
Identities = 86/273 (31%), Positives = 129/273 (47%), Gaps = 21/273 (7%)
Query: 73 QGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSE 132
QG R MED L ++F + DGHGG AA + LP + Q L +
Sbjct: 99 QGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKD 157
Query: 133 PEG----VREALRRAFLSAD-ERLRSLWPRVETGGCTAVVLLVSPRFLYLAHCGDSRAVL 187
E + L + LS D E L L + G T ++ L+S + L +A+ GDSR VL
Sbjct: 158 KENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVL 217
Query: 188 -SRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRR---RVEGSLAVSRALGDFTYKEAPG 243
+ G + DH+P + +ER+RI AGG I RV+G LA+SR+LGD+ K
Sbjct: 218 CDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKN--- 274
Query: 244 RPPELQLVSAEPEVAAL-ARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPELL 302
L +V +P++ + + EFM+LASDG+WD S + RL P
Sbjct: 275 ----LNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLD---EPHFG 327
Query: 303 CAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEE 335
++ +G DN+T ++V F + + E+
Sbjct: 328 AKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
>gi|13540531 integrin-linked kinase-associated protein phosphatase
2C [Homo sapiens]
Length = 392
Score = 105 bits (263), Expect = 6e-23
Identities = 89/291 (30%), Positives = 134/291 (46%), Gaps = 38/291 (13%)
Query: 64 GLRFGASAAQGWRARMEDAHCTWLSLPG--LPPGWAL-----FAVLDGHGGARAARFGAR 116
GL+ + +G R M+DAH + PP + FAV DGHGG RA++F A+
Sbjct: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
Query: 117 HLPGHVLQEL--GPEPSEPEGVREALRRAFLSADERL---RSLWPRVETGGCTAVVLLVS 171
+L +++++ G S + V+ L F DE S G TA +L
Sbjct: 166 NLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAV 225
Query: 172 PRFLYLAHCGDSRAVLSRAG------AVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEG 225
LY+A+ GDSRA+L R A +++H P + ER RI AGG +R RV G
Sbjct: 226 DNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLG 285
Query: 226 SLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAAL 285
L VSR++GD YK V++ P++ D F+LLA DG++ +
Sbjct: 286 VLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEA 337
Query: 286 AGLVASRL-------RLGLAP-----ELLCAQLLDTCLCKGSLDNMTCILV 324
+ S L R G + E C +L + + +GS DN+T ++V
Sbjct: 338 VNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
>gi|30089948 protein phosphatase 1E [Homo sapiens]
Length = 755
Score = 102 bits (254), Expect = 7e-22
Identities = 86/264 (32%), Positives = 124/264 (46%), Gaps = 23/264 (8%)
Query: 71 AAQGWRARMEDAHCTWLSLPGL-----PPGWALFAVLDGHGGARAARFGARHLPGHVLQE 125
A + R +MED H L A FAV DGHGG AA + + HL HV
Sbjct: 236 AIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHL--HV--N 291
Query: 126 LGPEPSEPEGVREALRRAFLSADERLRSLWPRVETG-GCTAVVLLVSPRFLYLAHCGDSR 184
L + P EAL RAF DER R G T VV + L++A GDS+
Sbjct: 292 LVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQ 351
Query: 185 AVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTI---RRRRVEGSLAVSRALGDFTYKEA 241
+L R G + H+P R E++RI A GG + RV GSL+VSRA+GD +K
Sbjct: 352 VMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK-- 409
Query: 242 PGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPEL 301
+ + + A+ +++++LA DG +DTV+ +V+ L+
Sbjct: 410 -------PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSS 462
Query: 302 LCA-QLLDTCLCKGSLDNMTCILV 324
+ A +L+ + GS DN+T I+V
Sbjct: 463 MVAHKLVASARDAGSSDNITVIVV 486
>gi|4505997 protein phosphatase 1D [Homo sapiens]
Length = 605
Score = 96.3 bits (238), Expect = 5e-20
Identities = 77/229 (33%), Positives = 114/229 (49%), Gaps = 52/229 (22%)
Query: 97 ALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSEPEGVREALRRAFLS---ADERLRS 153
A FAV DGHGG AA+F HL G + ++ G SEP V A+R+ FL+ A + +
Sbjct: 99 AFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLA 158
Query: 154 LWPRVETG-----GCTAVVLLVSPRFLYLAHCGDSRAVLS----------RAGAVAFSTE 198
WP+ TG G TA V+++ +Y+AH GDS VL RA V T+
Sbjct: 159 EWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEV---TQ 215
Query: 199 DHRPLRPRERERIHAAGGTI-----------RRRRVEGS--------------LAVSRAL 233
DH+P P+ERERI GG++ +R R+ + LAV+RAL
Sbjct: 216 DHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARAL 275
Query: 234 GD-FTYKEAPGRPPELQLVSAEPEVAALARQAE-DEFMLLASDGVWDTV 280
GD ++Y G +VS EP+ + + ++++L SDG+W+ +
Sbjct: 276 GDLWSYDFFSGE----FVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMI 320
>gi|167466276 protein phosphatase 1K (PP2C domain containing) [Homo
sapiens]
Length = 372
Score = 84.0 bits (206), Expect = 2e-16
Identities = 76/240 (31%), Positives = 108/240 (45%), Gaps = 28/240 (11%)
Query: 99 FAVLDGHGGARAARFGARHLPGHVLQELGPEPSEPEGVREALRRAFLSADERLRS----- 153
FAV DGHGG AA F H+ ++ L E + + L AFL D+ S
Sbjct: 123 FAVYDGHGGPAAADFCHTHMEKCIMDLLPKE----KNLETLLTLAFLEIDKAFSSHARLS 178
Query: 154 LWPRVETGGCTAVVLLVSPRF-LYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIH 212
+ T G TA V L+ L +A GDSRA+L R G T DH P R E+ERI
Sbjct: 179 ADATLLTSGTTATVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIK 238
Query: 213 AAGG-----TIRRRRVEGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAAL-ARQAED 266
GG ++ + V G LA++R++GD K + V AEPE + A+D
Sbjct: 239 KCGGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSG--------VIAEPETKRIKLHHADD 290
Query: 267 EFMLLASDGVWDTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCF 326
F++L +DG+ V+ + V A + Q + G+ DN T ++V F
Sbjct: 291 SFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQ----YGTEDNSTAVVVPF 346
>gi|29558099 protein phosphatase 1B isoform 3 [Homo sapiens]
Length = 192
Score = 72.0 bits (175), Expect = 1e-12
Identities = 41/103 (39%), Positives = 60/103 (58%), Gaps = 8/103 (7%)
Query: 319 MTCILVCFPGAPRPSEEAIRRELALDAALGCRIAELCASAQKP--PSLNTVFRTLASEDI 376
M+ +LVCF AP+ S+EA++++ LD L R+ E+ + + P L V R L++E+I
Sbjct: 1 MSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENI 60
Query: 377 PDLPPGGGLDCKATVIAEVYSQICQ------VSEECGEKGQDG 413
P+LPPGGGL K VI VYS++ S+E E G G
Sbjct: 61 PNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQG 103
>gi|171460932 protein phosphatase 1M isoform a [Homo sapiens]
Length = 298
Score = 62.0 bits (149), Expect = 1e-09
Identities = 66/243 (27%), Positives = 97/243 (39%), Gaps = 68/243 (27%)
Query: 117 HLPGHVLQELGPEPSEPEGVRE------ALRRAFLSADERL-RSLWPRVETGGCTAVVLL 169
HL G + P+ E +G+R AL AF DE + R L + GGCTA+V +
Sbjct: 2 HLNGRCICPSDPQFVEEKGIRAEDLVIGALESAFQECDEVIGRELEASGQMGGCTALVAV 61
Query: 170 VSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERI------------------ 211
LY+A+ GDSRA+L R + + + P ER+RI
Sbjct: 62 SLQGKLYMANAGDSRAILVRRDEIRPLSFEFTP--ETERQRIQQLAFVYPELLAGEFTRL 119
Query: 212 --------------------HAAG-----------------GTIRRRRVEGSLAVSRALG 234
H +G G R+ R+ G+LAVSR LG
Sbjct: 120 EFPRRLKGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLIHGQGRQARLLGTLAVSRGLG 179
Query: 235 DFTYKEAPGRPPELQLVSAEPEVAAL----ARQAEDEFMLLASDGVWDTVSGAALAGLVA 290
D + + + P+V L ED+ +++A+DG+WD +S +A LV
Sbjct: 180 DHQLRVLDTNIQLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVR 239
Query: 291 SRL 293
S L
Sbjct: 240 SFL 242
>gi|45439339 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 3 precursor [Homo sapiens]
Length = 537
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 50/220 (22%)
Query: 123 LQELGPEPSEPEGVREALRRAFLSADER-------------LRSLWPRVETGGCTAVVLL 169
L +L S V+EAL AF D L L RV G TA V
Sbjct: 219 LIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAH 278
Query: 170 VSPRFLYLAHCGDSRAVLSRA------GAVAFSTEDHRPLRPRERERIHA------AGGT 217
V L++A+ GDSRA+L AV S DH RE ER+ A
Sbjct: 279 VDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSN-DHNAQNERELERLKLEHPKSEAKSV 337
Query: 218 IRRRRVEGSLAVSRALGDFTYK-----------EAPGR----------PPELQL---VSA 253
+++ R+ G L RA GD +K P + PP ++A
Sbjct: 338 VKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTA 397
Query: 254 EPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRL 293
EPEV + +D+F++LA+DG+W+T+ + +V L
Sbjct: 398 EPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYL 437
>gi|239985428 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 3 precursor [Homo sapiens]
Length = 537
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 50/220 (22%)
Query: 123 LQELGPEPSEPEGVREALRRAFLSADER-------------LRSLWPRVETGGCTAVVLL 169
L +L S V+EAL AF D L L RV G TA V
Sbjct: 219 LIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAH 278
Query: 170 VSPRFLYLAHCGDSRAVLSRA------GAVAFSTEDHRPLRPRERERIHA------AGGT 217
V L++A+ GDSRA+L AV S DH RE ER+ A
Sbjct: 279 VDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSN-DHNAQNERELERLKLEHPKSEAKSV 337
Query: 218 IRRRRVEGSLAVSRALGDFTYK-----------EAPGR----------PPELQL---VSA 253
+++ R+ G L RA GD +K P + PP ++A
Sbjct: 338 VKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTA 397
Query: 254 EPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRL 293
EPEV + +D+F++LA+DG+W+T+ + +V L
Sbjct: 398 EPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYL 437
>gi|239985426 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 2 [Homo sapiens]
Length = 562
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 50/220 (22%)
Query: 123 LQELGPEPSEPEGVREALRRAFLSADER-------------LRSLWPRVETGGCTAVVLL 169
L +L S V+EAL AF D L L RV G TA V
Sbjct: 244 LIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAH 303
Query: 170 VSPRFLYLAHCGDSRAVLSRA------GAVAFSTEDHRPLRPRERERIHA------AGGT 217
V L++A+ GDSRA+L AV S DH RE ER+ A
Sbjct: 304 VDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSN-DHNAQNERELERLKLEHPKSEAKSV 362
Query: 218 IRRRRVEGSLAVSRALGDFTYK-----------EAPGR----------PPELQL---VSA 253
+++ R+ G L RA GD +K P + PP ++A
Sbjct: 363 VKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTA 422
Query: 254 EPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRL 293
EPEV + +D+F++LA+DG+W+T+ + +V L
Sbjct: 423 EPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYL 462
>gi|239985422 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 2 [Homo sapiens]
Length = 562
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 50/220 (22%)
Query: 123 LQELGPEPSEPEGVREALRRAFLSADER-------------LRSLWPRVETGGCTAVVLL 169
L +L S V+EAL AF D L L RV G TA V
Sbjct: 244 LIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAH 303
Query: 170 VSPRFLYLAHCGDSRAVLSRA------GAVAFSTEDHRPLRPRERERIHA------AGGT 217
V L++A+ GDSRA+L AV S DH RE ER+ A
Sbjct: 304 VDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSN-DHNAQNERELERLKLEHPKSEAKSV 362
Query: 218 IRRRRVEGSLAVSRALGDFTYK-----------EAPGR----------PPELQL---VSA 253
+++ R+ G L RA GD +K P + PP ++A
Sbjct: 363 VKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTA 422
Query: 254 EPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRL 293
EPEV + +D+F++LA+DG+W+T+ + +V L
Sbjct: 423 EPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYL 462
>gi|239985420 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 1 [Homo sapiens]
Length = 596
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 50/220 (22%)
Query: 123 LQELGPEPSEPEGVREALRRAFLSADER-------------LRSLWPRVETGGCTAVVLL 169
L +L S V+EAL AF D L L RV G TA V
Sbjct: 278 LIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAH 337
Query: 170 VSPRFLYLAHCGDSRAVLSRA------GAVAFSTEDHRPLRPRERERIHA------AGGT 217
V L++A+ GDSRA+L AV S DH RE ER+ A
Sbjct: 338 VDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSN-DHNAQNERELERLKLEHPKSEAKSV 396
Query: 218 IRRRRVEGSLAVSRALGDFTYK-----------EAPGR----------PPELQL---VSA 253
+++ R+ G L RA GD +K P + PP ++A
Sbjct: 397 VKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTA 456
Query: 254 EPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRL 293
EPEV + +D+F++LA+DG+W+T+ + +V L
Sbjct: 457 EPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYL 496
>gi|171460934 protein phosphatase 1M isoform b [Homo sapiens]
Length = 247
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/192 (26%), Positives = 76/192 (39%), Gaps = 61/192 (31%)
Query: 161 GGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERI--------- 211
GGCTA+V + LY+A+ GDSRA+L R + + + P ER+RI
Sbjct: 2 GGCTALVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTP--ETERQRIQQLAFVYPE 59
Query: 212 -----------------------------HAAG-----------------GTIRRRRVEG 225
H +G G R+ R+ G
Sbjct: 60 LLAGEFTRLEFPRRLKGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLIHGQGRQARLLG 119
Query: 226 SLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAAL----ARQAEDEFMLLASDGVWDTVS 281
+LAVSR LGD + + + P+V L ED+ +++A+DG+WD +S
Sbjct: 120 TLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLS 179
Query: 282 GAALAGLVASRL 293
+A LV S L
Sbjct: 180 NEQVAWLVRSFL 191
>gi|65506328 protein phosphatase 1J (PP2C domain containing) [Homo
sapiens]
Length = 505
Score = 50.1 bits (118), Expect = 4e-06
Identities = 64/293 (21%), Positives = 99/293 (33%), Gaps = 102/293 (34%)
Query: 96 WALFAVLDGHGGARAARFGARHLPGHVLQELG----------------------PEPSEP 133
W LF DGH G AA +R L H+ ++L P+ S+P
Sbjct: 154 WGLF---DGHAGGGAAEMASRLLHRHIREQLKDLVEILQDPSPPPLCLPTTPGTPDSSDP 210
Query: 134 EG-------------------VREALRRAFLSADERL-RSLWPRVETGGCTAVVLLVSPR 173
V A+ AF DE++ R GGC A+V++
Sbjct: 211 SHLLGPQSCWSSQKEVSHESLVVGAVENAFQLMDEQMARERRGHQVEGGCCALVVIYLLG 270
Query: 174 FLYLAHCGDSRAVLSRAGAVAFSTEDHRP------------LRPR--------------- 206
+Y+A+ GDSRA++ R G + + + P L+P
Sbjct: 271 KVYVANAGDSRAIIVRNGEIIPMSREFTPETERQRLQLLGFLKPELLGSEFTHLEFPRRV 330
Query: 207 --------------------------ERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKE 240
E R G ++ RV ++ V+R LGD + K
Sbjct: 331 LPKELGQRMLYRDQNMTGWAYKKIELEDLRFPLVCGEGKKARVMATIGVTRGLGDHSLKV 390
Query: 241 APGRPPELQLVSAEPEVAAL----ARQAEDEFMLLASDGVWDTVSGAALAGLV 289
P +S PEV D+ ++L +DG+WD + +A V
Sbjct: 391 CSSTLPIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTTDCEVAATV 443
>gi|41349497 pyruvate dehydrogenase phosphatase isoenzyme 2 [Homo
sapiens]
Length = 529
Score = 49.3 bits (116), Expect = 7e-06
Identities = 52/180 (28%), Positives = 74/180 (41%), Gaps = 34/180 (18%)
Query: 148 DERLRSLWPRVETGGCTAVVLLVSPRFLYLAHCGDSRAVL-----SRAGAVAFSTEDHRP 202
DE R+L +V G TA + V L++A+ GD RA+L + + T DH
Sbjct: 252 DEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNA 311
Query: 203 LRPRE-----RERIHAAGGTI-RRRRVEGSLAVSRALGDFTYKEAPG------------- 243
E RE + TI R+ G L RA GD K +
Sbjct: 312 WNQAELSRLKREHPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTE 371
Query: 244 -------RPPELQL---VSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRL 293
PP ++AEPEV + +D+F++LASDG+WD +S + LV L
Sbjct: 372 ALNIYQFTPPHYYTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHL 431
>gi|149944715 protein phosphatase 1H (PP2C domain containing) [Homo
sapiens]
Length = 514
Score = 45.4 bits (106), Expect = 1e-04
Identities = 52/215 (24%), Positives = 82/215 (38%), Gaps = 62/215 (28%)
Query: 139 ALRRAFLSAD---ERLRSLWPRVETGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAF 195
AL AF D ER RS + +GGCTA++++ LY+A+ GDSRA++ R G +
Sbjct: 244 ALESAFKEMDLQIERERSSYNI--SGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIP 301
Query: 196 STEDHRPLRPRERERI------HAAGGTIRR----RRVE--------------------- 224
+ + P R+R + H G RRV+
Sbjct: 302 MSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYK 361
Query: 225 ----------------------GSLAVSRALGDFTYKEAPGRPPELQLVSAEPEV----A 258
++ V+R LGD K +S+ PEV
Sbjct: 362 TIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDL 421
Query: 259 ALARQAEDEFMLLASDGVWDTVSGAALAGLVASRL 293
+ D+ ++LA+DG+WD +S +A + L
Sbjct: 422 SKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFL 456
>gi|5174703 mitogen-activated protein kinase kinase kinase 7
interacting protein 1 isoform alpha [Homo sapiens]
Length = 504
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 25/170 (14%)
Query: 133 PEGV-REALRRAFLSADERLRSLWPRVETGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAG 191
PEGV + L + ERL++L R +GG AVV ++ LY+A+ G +RA+L ++
Sbjct: 136 PEGVPQHQLPPQYQKILERLKTL-EREISGGAMAVVAVLLNNKLYVANVGTNRALLCKST 194
Query: 192 A----VAFSTEDHRPLRPRERERIHAAG---GTIRRRRVEGSLAVSRALGDFTYK----- 239
V DH E R+ G G I++ + +R +GD+ K
Sbjct: 195 VDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTD 254
Query: 240 -----EAPGRPPELQLVSAEPEV-AALARQAEDEFMLLASDGVWDTVSGA 283
A +P + AEPE+ A F++L S+G++ + A
Sbjct: 255 IDLLSAAKSKP-----IIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAA 299
>gi|41281798 mitogen-activated protein kinase kinase kinase 7
interacting protein 1 isoform beta [Homo sapiens]
Length = 462
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 25/170 (14%)
Query: 133 PEGV-REALRRAFLSADERLRSLWPRVETGGCTAVVLLVSPRFLYLAHCGDSRAVLSRAG 191
PEGV + L + ERL++L R +GG AVV ++ LY+A+ G +RA+L ++
Sbjct: 136 PEGVPQHQLPPQYQKILERLKTL-EREISGGAMAVVAVLLNNKLYVANVGTNRALLCKST 194
Query: 192 A----VAFSTEDHRPLRPRERERIHAAG---GTIRRRRVEGSLAVSRALGDFTYK----- 239
V DH E R+ G G I++ + +R +GD+ K
Sbjct: 195 VDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTD 254
Query: 240 -----EAPGRPPELQLVSAEPEV-AALARQAEDEFMLLASDGVWDTVSGA 283
A +P + AEPE+ A F++L S+G++ + A
Sbjct: 255 IDLLSAAKSKP-----IIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAA 299
>gi|164419758 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 36.6 bits (83), Expect = 0.045
Identities = 27/83 (32%), Positives = 40/83 (48%), Gaps = 8/83 (9%)
Query: 17 KKKEREKE---GREEEEEEEAGRRAPEGPRSLLTAPRRAQRPHGGAEASGGLRFGASAAQ 73
KKK+R+ E GR +E++ G RAP P+ ++A GG+ A G FG S
Sbjct: 554 KKKKRKAEKHRGRAGADEDDKGPRAPRPPQP--KKSKKASGSGGGSAALGPSGFGPSGGS 611
Query: 74 GWRARMEDAHCTWLSLPGLPPGW 96
G + + T + P LP G+
Sbjct: 612 GTKLPKK---ATKTAPPALPTGY 631
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,613,786
Number of Sequences: 37866
Number of extensions: 1013833
Number of successful extensions: 8792
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 8094
Number of HSP's gapped (non-prelim): 567
length of query: 430
length of database: 18,247,518
effective HSP length: 105
effective length of query: 325
effective length of database: 14,271,588
effective search space: 4638266100
effective search space used: 4638266100
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.