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Search of human proteins with 24041020
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24041020 embryonic ectoderm development isoform a [Homo
sapiens]
(441 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24041020 embryonic ectoderm development isoform a [Homo sapiens] 929 0.0
gi|24041023 embryonic ectoderm development isoform b [Homo sapiens] 843 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 65 1e-10
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 55 1e-07
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 55 1e-07
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 55 1e-07
gi|16554629 WD repeat domain 5 [Homo sapiens] 54 2e-07
gi|16554627 WD repeat domain 5 [Homo sapiens] 54 2e-07
gi|26665869 WD repeat domain 51B [Homo sapiens] 54 3e-07
gi|21071067 TBP-associated factor 5 [Homo sapiens] 53 5e-07
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 53 6e-07
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 53 6e-07
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 53 6e-07
gi|188219762 denticleless homolog [Homo sapiens] 52 8e-07
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 52 1e-06
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 52 1e-06
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 52 1e-06
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 51 2e-06
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 50 4e-06
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 50 5e-06
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 49 7e-06
gi|19913369 transducin beta-like 3 [Homo sapiens] 49 7e-06
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 48 2e-05
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 48 2e-05
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 48 2e-05
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 48 2e-05
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 47 3e-05
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 47 3e-05
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 47 3e-05
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 47 5e-05
>gi|24041020 embryonic ectoderm development isoform a [Homo sapiens]
Length = 441
Score = 929 bits (2401), Expect = 0.0
Identities = 441/441 (100%), Positives = 441/441 (100%)
Query: 1 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 60
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
Sbjct: 1 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 60
Query: 61 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 120
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
Sbjct: 61 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 120
Query: 121 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 180
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
Sbjct: 121 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 180
Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
Sbjct: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240
Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 300
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
Sbjct: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 300
Query: 301 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 360
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
Sbjct: 301 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 360
Query: 361 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 420
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
Sbjct: 361 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 420
Query: 421 DSSILIAVCDDASIWRWDRLR 441
DSSILIAVCDDASIWRWDRLR
Sbjct: 421 DSSILIAVCDDASIWRWDRLR 441
>gi|24041023 embryonic ectoderm development isoform b [Homo sapiens]
Length = 400
Score = 843 bits (2177), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 60
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
Sbjct: 1 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 60
Query: 61 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 120
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
Sbjct: 61 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 120
Query: 121 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 180
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
Sbjct: 121 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 180
Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
Sbjct: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240
Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 300
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
Sbjct: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 300
Query: 301 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 360
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
Sbjct: 301 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 360
Query: 361 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK 400
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK
Sbjct: 361 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK 400
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 65.1 bits (157), Expect = 1e-10
Identities = 33/103 (32%), Positives = 58/103 (56%), Gaps = 4/103 (3%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
L+A A + G RI + T +CI GH I+++ F+P+ N LL+ S D R+W+ Q
Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG-NHLLTGSSDKTARIWDAQ 375
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264
T + + +EGH DE+ S ++ G +++ D++ ++WR
Sbjct: 376 TGQCLQV---LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 47.8 bits (112), Expect = 2e-05
Identities = 27/96 (28%), Positives = 51/96 (53%), Gaps = 4/96 (4%)
Query: 179 TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE 238
T +C + GH I L F+P+ L+ + S D +LW+IQ V + GH E
Sbjct: 166 TGKCYHTFRGHTAEIVCLSFNPQS-TLVATGSMDTTAKLWDIQNGEEVYT---LRGHSAE 221
Query: 239 VLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274
++S ++ G++I++ DH++ +W ++ R +N +
Sbjct: 222 IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL 257
Score = 37.4 bits (85), Expect = 0.027
Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 4/83 (4%)
Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246
+GH I+ F+ D +L+L+ S D +LW+ VA + GH DE+L + +D
Sbjct: 258 IGHCAEISSASFN-WDCSLILTGSMDKTCKLWDATNGKCVAT---LTGHDDEILDSCFDY 313
Query: 247 LGEKIMSCGMDHSLKLWRINSKR 269
G+ I + D + +++ +++
Sbjct: 314 TGKLIATASADGTARIFSAATRK 336
Score = 35.0 bits (79), Expect = 0.14
Identities = 19/80 (23%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247
GH N + + F+ + + + S D +LW+++T F GH E++ ++
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTF---RGHTAEIVCLSFNPQ 188
Query: 248 GEKIMSCGMDHSLKLWRINS 267
+ + MD + KLW I +
Sbjct: 189 STLVATGSMDTTAKLWDIQN 208
Score = 31.6 bits (70), Expect = 1.5
Identities = 19/99 (19%), Positives = 44/99 (44%), Gaps = 4/99 (4%)
Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240
+C+ GH + I + F L+ + S D R+++ T +A +EGH E+
Sbjct: 294 KCVATLTGHDDEILDSCFDYTG-KLIATASADGTARIFSAATRKCIA---KLEGHEGEIS 349
Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279
++ G +++ D + ++W + + + ++ D
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD 388
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 55.5 bits (132), Expect = 1e-07
Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 4/118 (3%)
Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214
D + PL G I++ N +C+ +GH + I FH P +LS S D
Sbjct: 58 DFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYP-WILSASDDQT 116
Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN 272
+R+WN Q+ T V + + GH V+ A + + ++S +D ++++W I+ R N
Sbjct: 117 IRVWNWQSRTCVCV---LTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKN 171
Score = 43.1 bits (100), Expect = 5e-04
Identities = 41/174 (23%), Positives = 72/174 (41%), Gaps = 30/174 (17%)
Query: 193 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM 252
+ L FHP+ P +L S+ ++LW+ + TL+ F + H V D+ +
Sbjct: 12 VKGLSFHPKRPWILTSLHNG-VIQLWDYRMCTLIDKF---DEHDGPVRGIDFHKQQPLFV 67
Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPN---KTNRPFI-----SQKIHFPDFSTRDI 304
S G D+ +K+W +R + + DY P+I Q I ++ +R
Sbjct: 68 SGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTC 127
Query: 305 ------HRNYVDCVRW--LGDLILSKSCENAIVCW----------KPGKMEDDI 340
H +YV C ++ DL++S S + + W PG +E D+
Sbjct: 128 VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDV 181
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/98 (24%), Positives = 47/98 (47%), Gaps = 3/98 (3%)
Query: 183 IKHYV-GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS 241
+KH + GH +N FHP P L++S + D +++W + + GH + V
Sbjct: 197 VKHVLEGHDRGVNWAAFHPTMP-LIVSGADDRQVKIWRMNESKAWEV-DTCRGHYNNVSC 254
Query: 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279
A + E I+S D S+++W ++ + + + +D
Sbjct: 255 AVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHD 292
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 55.5 bits (132), Expect = 1e-07
Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 4/118 (3%)
Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214
D + PL G I++ N +C+ +GH + I FH P +LS S D
Sbjct: 58 DFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYP-WILSASDDQT 116
Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN 272
+R+WN Q+ T V + + GH V+ A + + ++S +D ++++W I+ R N
Sbjct: 117 IRVWNWQSRTCVCV---LTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKN 171
Score = 43.1 bits (100), Expect = 5e-04
Identities = 41/174 (23%), Positives = 72/174 (41%), Gaps = 30/174 (17%)
Query: 193 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM 252
+ L FHP+ P +L S+ ++LW+ + TL+ F + H V D+ +
Sbjct: 12 VKGLSFHPKRPWILTSLHNG-VIQLWDYRMCTLIDKF---DEHDGPVRGIDFHKQQPLFV 67
Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPN---KTNRPFI-----SQKIHFPDFSTRDI 304
S G D+ +K+W +R + + DY P+I Q I ++ +R
Sbjct: 68 SGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTC 127
Query: 305 ------HRNYVDCVRW--LGDLILSKSCENAIVCW----------KPGKMEDDI 340
H +YV C ++ DL++S S + + W PG +E D+
Sbjct: 128 VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDV 181
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/98 (24%), Positives = 47/98 (47%), Gaps = 3/98 (3%)
Query: 183 IKHYV-GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS 241
+KH + GH +N FHP P L++S + D +++W + + GH + V
Sbjct: 197 VKHVLEGHDRGVNWAAFHPTMP-LIVSGADDRQVKIWRMNESKAWEV-DTCRGHYNNVSC 254
Query: 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279
A + E I+S D S+++W ++ + + + +D
Sbjct: 255 AVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHD 292
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 55.5 bits (132), Expect = 1e-07
Identities = 35/106 (33%), Positives = 52/106 (49%), Gaps = 4/106 (3%)
Query: 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 242
++ Y GH ++ +KFHP N L + S D +RLW+ Q V +F GHR VLS
Sbjct: 419 LRIYAGHLADVDCVKFHPNS-NYLATGSTDKTVRLWSAQQGNSVRLF---TGHRGPVLSL 474
Query: 243 DYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288
+ G+ + S G D LKLW + S + ++ D + T P
Sbjct: 475 AFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSP 520
Score = 45.8 bits (107), Expect = 8e-05
Identities = 27/105 (25%), Positives = 49/105 (46%), Gaps = 4/105 (3%)
Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222
LA + +R+ + ++ + GH + L F P L S +D L+LW++ +
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG-KYLASAGEDQRLKLWDLAS 499
Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267
TL + + GH D + S + I S MD+S+++W I +
Sbjct: 500 GTL---YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 28.9 bits (63), Expect = 9.7
Identities = 20/76 (26%), Positives = 34/76 (44%), Gaps = 4/76 (5%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247
GH + +F D + LLS S+D ++R W++ + T ++ +GH V D
Sbjct: 340 GHCGPVYSTRFLA-DSSGLLSCSEDMSIRYWDLGSFTNTVLY---QGHAYPVWDLDISPY 395
Query: 248 GEKIMSCGMDHSLKLW 263
S D + +LW
Sbjct: 396 SLYFASGSHDRTARLW 411
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/245 (22%), Positives = 103/245 (42%), Gaps = 46/245 (18%)
Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210
AW+ DSN LL A ++I + + +C+K GH N + F+P+ NL++S S
Sbjct: 94 AWSSDSN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGS 148
Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270
D ++R+W+++T + + H D V + ++ G I+S D ++W S +
Sbjct: 149 FDESVRIWDVKTGKCLKT---LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 271 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVC 330
+ + + D NP + F FS G IL+ + +N +
Sbjct: 206 LKTLID--DDNP----------PVSFVKFSPN-------------GKYILAATLDNTLKL 240
Query: 331 WKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWD 390
W K + T G + C + FS+ K + G++ +Y+W+
Sbjct: 241 WDYSK----------GKCLKTYTGHKNEKYC--IFANFSVT-GGKWIVSGSEDNLVYIWN 287
Query: 391 LEVED 395
L+ ++
Sbjct: 288 LQTKE 292
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/117 (22%), Positives = 57/117 (48%), Gaps = 4/117 (3%)
Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222
LA + + +I+I + K GH I+++ + D NLL+S S D L++W++ +
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSS 118
Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279
+ ++GH + V +++ I+S D S+++W + + + + + D
Sbjct: 119 GKCLKT---LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172
Score = 41.2 bits (95), Expect = 0.002
Identities = 44/186 (23%), Positives = 83/186 (44%), Gaps = 20/186 (10%)
Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142
KC+ +L H+ P+ V FN ++G +V ++ L + L++ +D
Sbjct: 162 KCLKTLPA-HSDPVSAVHFN---RDGSLIVSSSYDG----LCRIWDTASGQCLKTLID-- 211
Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL--KFHP 200
D+N + N + L A + +++ + +C+K Y GH N + F
Sbjct: 212 -DDNPPVSFVKFSPNGKYILAATLDNT--LKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268
Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM--DH 258
++S S+D+ + +WN+QT +V ++GH D V+S I S + D
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQ---KLQGHTDVVISTACHPTENIIASAALENDK 325
Query: 259 SLKLWR 264
++KLW+
Sbjct: 326 TIKLWK 331
Score = 38.9 bits (89), Expect = 0.009
Identities = 26/94 (27%), Positives = 44/94 (46%), Gaps = 6/94 (6%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE-GHRDEVLSADYDL 246
GH A++ +KF P L S S D +++W G + G D S+D +L
Sbjct: 43 GHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 247 LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280
L +S D +LK+W ++S + + +K +Y
Sbjct: 102 L----VSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
Score = 35.4 bits (80), Expect = 0.10
Identities = 32/140 (22%), Positives = 65/140 (46%), Gaps = 13/140 (9%)
Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140
S +C+ +L +D N P+ V+F+ + K + A N + L++ +S+G + L++Y
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGK----YILAATLDNTLKLWD-YSKG--KCLKTYT- 253
Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200
+N C + S T + ++ I N T + ++ GH + + HP
Sbjct: 254 --GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Query: 201 RDPNLLLS--VSKDHALRLW 218
+ N++ S + D ++LW
Sbjct: 312 TE-NIIASAALENDKTIKLW 330
Score = 29.3 bits (64), Expect = 7.5
Identities = 13/36 (36%), Positives = 23/36 (63%), Gaps = 2/36 (5%)
Query: 403 TLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438
T++ HK G I ++S DS++L++ DD ++ WD
Sbjct: 82 TISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWD 115
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/245 (22%), Positives = 103/245 (42%), Gaps = 46/245 (18%)
Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210
AW+ DSN LL A ++I + + +C+K GH N + F+P+ NL++S S
Sbjct: 94 AWSSDSN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGS 148
Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270
D ++R+W+++T + + H D V + ++ G I+S D ++W S +
Sbjct: 149 FDESVRIWDVKTGKCLKT---LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 271 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVC 330
+ + + D NP + F FS G IL+ + +N +
Sbjct: 206 LKTLID--DDNP----------PVSFVKFSPN-------------GKYILAATLDNTLKL 240
Query: 331 WKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWD 390
W K + T G + C + FS+ K + G++ +Y+W+
Sbjct: 241 WDYSK----------GKCLKTYTGHKNEKYC--IFANFSVT-GGKWIVSGSEDNLVYIWN 287
Query: 391 LEVED 395
L+ ++
Sbjct: 288 LQTKE 292
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/117 (22%), Positives = 57/117 (48%), Gaps = 4/117 (3%)
Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222
LA + + +I+I + K GH I+++ + D NLL+S S D L++W++ +
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSS 118
Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279
+ ++GH + V +++ I+S D S+++W + + + + + D
Sbjct: 119 GKCLKT---LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172
Score = 41.2 bits (95), Expect = 0.002
Identities = 44/186 (23%), Positives = 83/186 (44%), Gaps = 20/186 (10%)
Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142
KC+ +L H+ P+ V FN ++G +V ++ L + L++ +D
Sbjct: 162 KCLKTLPA-HSDPVSAVHFN---RDGSLIVSSSYDG----LCRIWDTASGQCLKTLID-- 211
Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL--KFHP 200
D+N + N + L A + +++ + +C+K Y GH N + F
Sbjct: 212 -DDNPPVSFVKFSPNGKYILAATLDNT--LKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268
Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM--DH 258
++S S+D+ + +WN+QT +V ++GH D V+S I S + D
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQ---KLQGHTDVVISTACHPTENIIASAALENDK 325
Query: 259 SLKLWR 264
++KLW+
Sbjct: 326 TIKLWK 331
Score = 38.9 bits (89), Expect = 0.009
Identities = 26/94 (27%), Positives = 44/94 (46%), Gaps = 6/94 (6%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE-GHRDEVLSADYDL 246
GH A++ +KF P L S S D +++W G + G D S+D +L
Sbjct: 43 GHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 247 LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280
L +S D +LK+W ++S + + +K +Y
Sbjct: 102 L----VSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
Score = 35.4 bits (80), Expect = 0.10
Identities = 32/140 (22%), Positives = 65/140 (46%), Gaps = 13/140 (9%)
Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140
S +C+ +L +D N P+ V+F+ + K + A N + L++ +S+G + L++Y
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGK----YILAATLDNTLKLWD-YSKG--KCLKTYT- 253
Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200
+N C + S T + ++ I N T + ++ GH + + HP
Sbjct: 254 --GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Query: 201 RDPNLLLS--VSKDHALRLW 218
+ N++ S + D ++LW
Sbjct: 312 TE-NIIASAALENDKTIKLW 330
Score = 29.3 bits (64), Expect = 7.5
Identities = 13/36 (36%), Positives = 23/36 (63%), Gaps = 2/36 (5%)
Query: 403 TLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438
T++ HK G I ++S DS++L++ DD ++ WD
Sbjct: 82 TISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWD 115
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 53.9 bits (128), Expect = 3e-07
Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214
D N S +A AGS +++ + + ++HY H +N + FHP N L++ S D
Sbjct: 193 DFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP-SGNYLITASSDGT 251
Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266
L++ ++ L+ ++GH V + + GE S G D + LWR N
Sbjct: 252 LKILDLLEGRLIYT---LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/130 (23%), Positives = 56/130 (43%), Gaps = 10/130 (7%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
LLA A +R+ P + H + + F D L + S+D ++++W++
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSA-DGQFLATASEDKSIKVWSMY 132
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES---- 277
+ + H V A + G I+SC D ++K+W +K+ +N +S
Sbjct: 133 RQRFLY---SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA 189
Query: 278 --YDYNPNKT 285
D+NP+ T
Sbjct: 190 NFVDFNPSGT 199
Score = 39.3 bits (90), Expect = 0.007
Identities = 27/117 (23%), Positives = 52/117 (44%), Gaps = 4/117 (3%)
Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214
D + LA A I++ + + + H + + KF P D L++S S+D
Sbjct: 109 DFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP-DGRLIVSCSEDKT 167
Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM 271
+++W+ V F G + V D++ G I S G D ++K+W + +++
Sbjct: 168 IKIWDTTNKQCVNNFSDSVGFANFV---DFNPSGTCIASAGSDQTVKVWDVRVNKLL 221
Score = 37.4 bits (85), Expect = 0.027
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 4/80 (5%)
Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243
+++ GH AI L P L + S D L LWN + + GH+D V S
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLA-TASWDTFLMLWNFKPHARAYRY---VGHKDVVTSVQ 67
Query: 244 YDLLGEKIMSCGMDHSLKLW 263
+ G + S D +++LW
Sbjct: 68 FSPHGNLLASASRDRTVRLW 87
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 53.1 bits (126), Expect = 5e-07
Identities = 46/184 (25%), Positives = 86/184 (46%), Gaps = 20/184 (10%)
Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVT-LYECHSQGEIRLLQSYV 139
+F C+ K HN P++ QF+ + F + G +RV L+ +R+ ++
Sbjct: 574 TFTCLVGYK-GHNYPVWDTQFSPYG-----YYFVSGGHDRVARLWATDHYQPLRIFAGHL 627
Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFH 199
AD N + N+++ +A + +R+ + + C++ + GH I+ L F
Sbjct: 628 ---ADVN----CTRFHPNSNY--VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678
Query: 200 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHS 259
P L + + D + LW+I +V G ++GH D V S + GE + S MD++
Sbjct: 679 PNG-RFLATGATDGRVLLWDIGHGLMV---GELKGHTDTVCSLRFSRDGEILASGSMDNT 734
Query: 260 LKLW 263
++LW
Sbjct: 735 VRLW 738
Score = 49.7 bits (117), Expect = 5e-06
Identities = 64/269 (23%), Positives = 99/269 (36%), Gaps = 52/269 (19%)
Query: 173 RIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV 232
RI++ T +K GH + F P D N LLS S+D +RLW++QT T + G
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLV---GY 581
Query: 233 EGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQ 292
+GH V + G +S G D +LW + Y P R F
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD------------HYQP---LRIFAG- 625
Query: 293 KIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTI 352
H D + H N + + + S + + W N
Sbjct: 626 --HLADVNCTRFHPN--------SNYVATGSADRTVRLW--------------DVLNGNC 661
Query: 353 LGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAA 412
+ F + I + FS + + LA G G++ +WD+ H L H
Sbjct: 662 VRIFTGHKGPIHSLTFSPN--GRFLATGATDGRVLLWDI----GHGLMVGELKGHT--DT 713
Query: 413 IRQTSFSRDSSILIAVCDDASIWRWDRLR 441
+ FSRD IL + D ++ WD ++
Sbjct: 714 VCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 32.7 bits (73), Expect = 0.67
Identities = 40/188 (21%), Positives = 72/188 (38%), Gaps = 20/188 (10%)
Query: 170 GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229
G +R+ + T C+ Y GH + + +F P +S D RLW + IF
Sbjct: 565 GTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-YYFVSGGHDRVARLWATDHYQPLRIF 623
Query: 230 GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI---NSKRMMNAIK---ESYDYNPN 283
GH +V + + + D +++LW + N R+ K S ++PN
Sbjct: 624 A---GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680
Query: 284 --------KTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKP 333
R + H H + V +R+ G+++ S S +N + W
Sbjct: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740
Query: 334 GKMEDDID 341
K +D++
Sbjct: 741 IKAFEDLE 748
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 52.8 bits (125), Expect = 6e-07
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214
D + S +A AG +++ + T + ++HY H A+N L FHP N L++ S D
Sbjct: 156 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDST 214
Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266
L++ ++ L+ + GH+ + + GE S G D + +W+ N
Sbjct: 215 LKILDLMEGRLLYT---LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
Score = 38.9 bits (89), Expect = 0.009
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248
H N + KF P D L++S S D ++LW+ + V + H V D+ G
Sbjct: 106 HINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCE---HGGFVTYVDFHPSG 161
Query: 249 EKIMSCGMDHSLKLWRINSKRMM 271
I + GMD+++K+W + + R++
Sbjct: 162 TCIAAAGMDNTVKVWDVRTHRLL 184
Score = 38.1 bits (87), Expect = 0.016
Identities = 20/110 (18%), Positives = 51/110 (46%), Gaps = 4/110 (3%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
L+ A +++ + + +C+ Y HG + + FHP + + D+ +++W+++
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR 179
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM 271
T L+ + + H V + G +++ D +LK+ + R++
Sbjct: 180 THRLLQHY---QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL 226
Score = 30.4 bits (67), Expect = 3.3
Identities = 31/144 (21%), Positives = 58/144 (40%), Gaps = 23/144 (15%)
Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK--- 268
D L +W+++ + F GH+D V ++ G + S D ++++W N K
Sbjct: 2 DSCLMVWHMKPQSRAYRF---TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 58
Query: 269 ---RMMNAIKESYDY----------NPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL 315
R A S + + +KT + + + + F + H N+V C ++
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF--LFSLSQHINWVRCAKFS 116
Query: 316 --GDLILSKSCENAIVCWKPGKME 337
G LI+S S + + W E
Sbjct: 117 PDGRLIVSASDDKTVKLWDKSSRE 140
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 52.8 bits (125), Expect = 6e-07
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214
D + S +A AG +++ + T + ++HY H A+N L FHP N L++ S D
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDST 252
Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266
L++ ++ L+ + GH+ + + GE S G D + +W+ N
Sbjct: 253 LKILDLMEGRLLYT---LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
Score = 38.9 bits (89), Expect = 0.009
Identities = 39/172 (22%), Positives = 71/172 (41%), Gaps = 24/172 (13%)
Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243
+H+ GH +A+ + F L S S D L +W+++ + F GH+D V +
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLA-SGSMDSCLMVWHMKPQSRAYRF---TGHKDAVTCVN 68
Query: 244 YDLLGEKIMSCGMDHSLKLWRINSK------RMMNAIKESYDY----------NPNKTNR 287
+ G + S D ++++W N K R A S + + +KT +
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 288 PFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKME 337
+ + + F + H N+V C ++ G LI+S S + + W E
Sbjct: 129 VWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Score = 38.9 bits (89), Expect = 0.009
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248
H N + KF P D L++S S D ++LW+ + V + H V D+ G
Sbjct: 144 HINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCE---HGGFVTYVDFHPSG 199
Query: 249 EKIMSCGMDHSLKLWRINSKRMM 271
I + GMD+++K+W + + R++
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLL 222
Score = 38.1 bits (87), Expect = 0.016
Identities = 20/110 (18%), Positives = 51/110 (46%), Gaps = 4/110 (3%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
L+ A +++ + + +C+ Y HG + + FHP + + D+ +++W+++
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR 217
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM 271
T L+ + + H V + G +++ D +LK+ + R++
Sbjct: 218 THRLLQHY---QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL 264
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 52.8 bits (125), Expect = 6e-07
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214
D + S +A AG +++ + T + ++HY H A+N L FHP N L++ S D
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDST 252
Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266
L++ ++ L+ + GH+ + + GE S G D + +W+ N
Sbjct: 253 LKILDLMEGRLLYT---LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
Score = 38.9 bits (89), Expect = 0.009
Identities = 39/172 (22%), Positives = 71/172 (41%), Gaps = 24/172 (13%)
Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243
+H+ GH +A+ + F L S S D L +W+++ + F GH+D V +
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLA-SGSMDSCLMVWHMKPQSRAYRF---TGHKDAVTCVN 68
Query: 244 YDLLGEKIMSCGMDHSLKLWRINSK------RMMNAIKESYDY----------NPNKTNR 287
+ G + S D ++++W N K R A S + + +KT +
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 288 PFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKME 337
+ + + F + H N+V C ++ G LI+S S + + W E
Sbjct: 129 VWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Score = 38.9 bits (89), Expect = 0.009
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248
H N + KF P D L++S S D ++LW+ + V + H V D+ G
Sbjct: 144 HINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCE---HGGFVTYVDFHPSG 199
Query: 249 EKIMSCGMDHSLKLWRINSKRMM 271
I + GMD+++K+W + + R++
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLL 222
Score = 38.1 bits (87), Expect = 0.016
Identities = 20/110 (18%), Positives = 51/110 (46%), Gaps = 4/110 (3%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
L+ A +++ + + +C+ Y HG + + FHP + + D+ +++W+++
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR 217
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM 271
T L+ + + H V + G +++ D +LK+ + R++
Sbjct: 218 THRLLQHY---QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL 264
>gi|188219762 denticleless homolog [Homo sapiens]
Length = 730
Score = 52.4 bits (124), Expect = 8e-07
Identities = 53/205 (25%), Positives = 94/205 (45%), Gaps = 30/205 (14%)
Query: 94 QPLFGVQFN-WHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAW 152
QP GV N W S+ PL + +T Y+C E SY + + C +
Sbjct: 9 QPQLGVLRNGWSSQY--PL------QSLLTGYQCSGNDEHT---SYGETGVPVPPFGCTF 57
Query: 153 TYDSNTSHPLLAVAGSRGIIRIINPITM----QCIKHYVGHGNAINELKFHPRDPNLLLS 208
+ N H +LAVA G +R+ N + +C K ++ H NA+ +L + P + L++
Sbjct: 58 SSAPNMEH-VLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELK-LVT 115
Query: 209 VSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSC--GMDHSLKLW--R 264
+ D + W+++ L+ G +GH+ + S + EK + C G D ++ +W R
Sbjct: 116 AAGDQTAKFWDVKAGELI---GTCKGHQCSLKSVAFSKF-EKAVFCTGGRDGNIMVWDTR 171
Query: 265 INSK----RMMNAIKESYDYNPNKT 285
N K R +N I +++ + +T
Sbjct: 172 CNKKDGFYRQVNQISGAHNTSDKQT 196
Score = 35.4 bits (80), Expect = 0.10
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 12/85 (14%)
Query: 188 GHGNAINELKFH-PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS----- 241
GH N+ +K D L+S S D A +W + T + GH EV S
Sbjct: 313 GHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTV--LLGHSQEVTSVCWCP 370
Query: 242 ADYDLLGEKIMSCGMDHSLKLWRIN 266
+D+ KI +C D++LK+WR+N
Sbjct: 371 SDFT----KIATCSDDNTLKIWRLN 391
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 52.0 bits (123), Expect = 1e-06
Identities = 59/284 (20%), Positives = 110/284 (38%), Gaps = 60/284 (21%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
++ S +R+ + T + + + H A+ L+F L+++ SKD ++ +W++
Sbjct: 292 VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF---SNGLMVTCSKDRSIAVWDMA 348
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281
+ T + + + GHR V D+D + I+S D ++K+W ++ + +
Sbjct: 349 SATDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNG----- 401
Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDID 341
H+ + C+++ L++S S +N I W
Sbjct: 402 -----------------------HKRGIACLQYRDRLVVSGSSDNTIRLWD--------- 429
Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE-DPHKAK 400
I+ + G + +C + F K + G GK+ VWDL+ DP
Sbjct: 430 -IECGACLRVLEGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDLQAALDPRAPA 480
Query: 401 CT----TLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440
T TL H G R D +I+ D +I WD L
Sbjct: 481 STLCLRTLVEHS-GRVFR---LQFDEFQIISSSHDDTILIWDFL 520
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 52.0 bits (123), Expect = 1e-06
Identities = 59/284 (20%), Positives = 110/284 (38%), Gaps = 60/284 (21%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
++ S +R+ + T + + + H A+ L+F L+++ SKD ++ +W++
Sbjct: 258 VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF---SNGLMVTCSKDRSIAVWDMA 314
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281
+ T + + + GHR V D+D + I+S D ++K+W ++ + +
Sbjct: 315 SATDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNG----- 367
Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDID 341
H+ + C+++ L++S S +N I W
Sbjct: 368 -----------------------HKRGIACLQYRDRLVVSGSSDNTIRLWD--------- 395
Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE-DPHKAK 400
I+ + G + +C + F K + G GK+ VWDL+ DP
Sbjct: 396 -IECGACLRVLEGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDLQAALDPRAPA 446
Query: 401 CT----TLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440
T TL H G R D +I+ D +I WD L
Sbjct: 447 STLCLRTLVEHS-GRVFR---LQFDEFQIISSSHDDTILIWDFL 486
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 52.0 bits (123), Expect = 1e-06
Identities = 59/284 (20%), Positives = 110/284 (38%), Gaps = 60/284 (21%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
++ S +R+ + T + + + H A+ L+F L+++ SKD ++ +W++
Sbjct: 279 VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF---SNGLMVTCSKDRSIAVWDMA 335
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281
+ T + + + GHR V D+D + I+S D ++K+W ++ + +
Sbjct: 336 SATDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNG----- 388
Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDID 341
H+ + C+++ L++S S +N I W
Sbjct: 389 -----------------------HKRGIACLQYRDRLVVSGSSDNTIRLWD--------- 416
Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE-DPHKAK 400
I+ + G + +C + F K + G GK+ VWDL+ DP
Sbjct: 417 -IECGACLRVLEGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDLQAALDPRAPA 467
Query: 401 CT----TLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440
T TL H G R D +I+ D +I WD L
Sbjct: 468 STLCLRTLVEHS-GRVFR---LQFDEFQIISSSHDDTILIWDFL 507
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 51.2 bits (121), Expect = 2e-06
Identities = 58/278 (20%), Positives = 109/278 (39%), Gaps = 43/278 (15%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
LLA + G I+I + T + + + V H + +L F P +L+S S+D LR+W+++
Sbjct: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281
D + + GH++ V S + + S G ++ LW ++ M+ ++
Sbjct: 202 DDG--NMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG----- 254
Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKP--GKMEDD 339
H D D + G L+ + S + + W P G + +
Sbjct: 255 -------------HHHDVVACDFSPD--------GALLATASYDTRVYIWDPHNGDILME 293
Query: 340 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 399
+ P + + F D W S+ F L + + V +++ +
Sbjct: 294 FGHLFPPPTPI-----FAGGANDRWVR--SVSFSHDGLHVASLADDKMVRFWRIDEDYPV 346
Query: 400 KCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437
+ L++ C A FS D S+L A D S++ W
Sbjct: 347 QVAPLSNGLCCA------FSTDGSVLAAGTHDGSVYFW 378
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 50.1 bits (118), Expect = 4e-06
Identities = 35/144 (24%), Positives = 68/144 (47%), Gaps = 13/144 (9%)
Query: 133 RLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA 192
R L+ + D+ D +F + S LLA + I++ + +CI+ GH +
Sbjct: 144 RTLKGHTDSVQDISF---------DHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHN 194
Query: 193 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM 252
++ + P +++ S S+D +++W +QT V F GHR+ V + G I
Sbjct: 195 VSSVAIMPNGDHIV-SASRDKTIKMWEVQTGYCVKTF---TGHREWVRMVRPNQDGTLIA 250
Query: 253 SCGMDHSLKLWRINSKRMMNAIKE 276
SC D ++++W + +K ++E
Sbjct: 251 SCSNDQTVRVWVVATKECKAELRE 274
Score = 46.6 bits (109), Expect = 5e-05
Identities = 37/156 (23%), Positives = 65/156 (41%), Gaps = 24/156 (15%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247
GH + + + FHP ++++S S+D +++W+ +T ++GH D V +D
Sbjct: 106 GHRSPVTRVIFHPVF-SVMVSASEDATIKVWDYETGDFERT---LKGHTDSVQDISFDHS 161
Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS------- 300
G+ + SC D ++KLW I+ + ++ N ++ + H S
Sbjct: 162 GKLLASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKM 218
Query: 301 ----------TRDIHRNYVDCVRWLGDLILSKSCEN 326
T HR +V VR D L SC N
Sbjct: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSN 254
Score = 39.7 bits (91), Expect = 0.006
Identities = 26/111 (23%), Positives = 47/111 (42%), Gaps = 4/111 (3%)
Query: 153 TYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKD 212
T S P L I++ + T C+ VGH N + + FH +LS + D
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFH-SGGKFILSCADD 359
Query: 213 HALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263
LR+W+ + + + H V S D+ +++ +D ++K+W
Sbjct: 360 KTLRVWDYKNKRCMKT---LNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 39.3 bits (90), Expect = 0.007
Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)
Query: 194 NELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMS 253
+E K + LLS S+D +++W++ T + + GH + V + G+ I+S
Sbjct: 299 SETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT---LVGHDNWVRGVLFHSGGKFILS 355
Query: 254 CGMDHSLKLWRINSKRMMNAI 274
C D +L++W +KR M +
Sbjct: 356 CADDKTLRVWDYKNKRCMKTL 376
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 49.7 bits (117), Expect = 5e-06
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 4/116 (3%)
Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216
NT L+ G IR+ + + ++ +GH I L FHP + S S+D ++
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG-EFVASGSQDTNIK 130
Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN 272
LW+I+ V + GH V + G+ + S DH++KLW + + +MM+
Sbjct: 131 LWDIRRKGCVFRY---RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS 183
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/107 (24%), Positives = 52/107 (48%), Gaps = 4/107 (3%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
LLA G + + + CI GH + + ++ + + L+++ S+ ++R+W+++
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE-ELIVAGSQSGSIRVWDLE 93
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK 268
I + GH+ + S D+ GE + S D ++KLW I K
Sbjct: 94 A---AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Score = 43.1 bits (100), Expect = 5e-04
Identities = 23/94 (24%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 182 CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS 241
C+ Y GH A+ L+F P D L S + DH ++LW++ +++ F GH V
Sbjct: 139 CVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTVKLWDLTAGKMMSEF---PGHTGPVNV 194
Query: 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275
++ + S D +++ W + ++++ I+
Sbjct: 195 VEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIE 228
Score = 36.6 bits (83), Expect = 0.047
Identities = 21/78 (26%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222
LA A +++ + + + + GH +N ++FHP + LL S S D +R W+++
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE-YLLASGSSDRTIRFWDLEK 220
Query: 223 DTLVAIFGGVEGHRDEVL 240
+V+ G G VL
Sbjct: 221 FQVVSCIEGEPGPVRSVL 238
Score = 31.2 bits (69), Expect = 2.0
Identities = 51/278 (18%), Positives = 103/278 (37%), Gaps = 52/278 (18%)
Query: 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 242
++ V H + ++ L LL + D + LW+I + + GH V S
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIM---SLTGHTSPVESV 69
Query: 243 DYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE------SYDYNPNKTNRPFISQKIHF 296
+ E I++ S+++W + + +++ + S D++P F++
Sbjct: 70 RLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHP---YGEFVASGSQD 126
Query: 297 PDFSTRDI-----------HRNYVDCVRWL--GDLILSKSCENAIVCW--KPGKMEDDID 341
+ DI H V C+R+ G + S + ++ + W GKM +
Sbjct: 127 TNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF- 185
Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKC 401
P + + F + + +LA G+ + WDLE K +
Sbjct: 186 ---PGHTGPVNVVEFHPN--------------EYLLASGSSDRTIRFWDLE-----KFQV 223
Query: 402 TTLTHHKCGAAIRQTSFSRDSSILIAVCDDA-SIWRWD 438
+ + G +R F+ D L + C D+ ++ W+
Sbjct: 224 VSCIEGEPG-PVRSVLFNPDGCCLYSGCQDSLRVYGWE 260
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/280 (20%), Positives = 110/280 (39%), Gaps = 46/280 (16%)
Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216
NT +L A + + + + T + +K GH + +N R P L+ + S D ++
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276
LW+I+ + F +VL+ ++ ++I+S G+D+ +K+W + ++ ++
Sbjct: 178 LWDIRKKAAIQTFQNTY----QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRG 233
Query: 277 SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKM 336
D + T S+ G +LS + +N + W
Sbjct: 234 HAD---SVTGLSLSSE-----------------------GSYLLSNAMDNTVRVW----- 262
Query: 337 EDDIDKIKPSESNVTIL-GRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 395
D+ P E V I G + ++ +S D +A G+ +YVWD
Sbjct: 263 --DVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD--GSKIAAGSADRFVYVWD----T 314
Query: 396 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW 435
+ L H +I + +F D I+I+ D ++
Sbjct: 315 TSRRILYKLPGH--AGSINEVAFHPDEPIIISASSDKRLY 352
Score = 39.7 bits (91), Expect = 0.006
Identities = 20/78 (25%), Positives = 40/78 (51%), Gaps = 5/78 (6%)
Query: 144 DENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDP 203
++N C+W+ D + +A + + + + + + + GH +INE+ FHP +P
Sbjct: 285 EKNLLRCSWSPDGSK----IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
Query: 204 NLLLSVSKDHALRLWNIQ 221
+++S S D L + IQ
Sbjct: 341 -IIISASSDKRLYMGEIQ 357
Score = 38.1 bits (87), Expect = 0.016
Identities = 22/88 (25%), Positives = 38/88 (43%), Gaps = 3/88 (3%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247
GH + KFHP + L S D + LWN+ D + ++GH V+ Y+
Sbjct: 64 GHEGEVYCCKFHPNG-STLASAGFDRLILLWNVYGDC--DNYATLKGHSGAVMELHYNTD 120
Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIK 275
G + S D ++ +W + + +K
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLK 148
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 49.3 bits (116), Expect = 7e-06
Identities = 30/107 (28%), Positives = 52/107 (48%), Gaps = 4/107 (3%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLL-SVSKDHALRLWNI 220
LLA G G +R+ + + H+ G ++ + FHP LLL S + D A+R+W++
Sbjct: 123 LLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSL 182
Query: 221 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267
Q + +A+ + H V S + G ++S G D +W + S
Sbjct: 183 QDRSCLAV---LTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
Score = 44.3 bits (103), Expect = 2e-04
Identities = 27/99 (27%), Positives = 47/99 (47%), Gaps = 4/99 (4%)
Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240
Q + + GH + ++F P D +L + S D ++LW +Q + + F EGH VL
Sbjct: 512 QLLGVFSGHRRGLWCVQFSPMD-QVLATASADGTIKLWALQDFSCLKTF---EGHDASVL 567
Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279
+ G +++S G D +KLW I + + + D
Sbjct: 568 KVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHED 606
Score = 42.0 bits (97), Expect = 0.001
Identities = 28/113 (24%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 152 WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSK 211
W + +LA A + G I++ C+K + GH ++ ++ F R LL S S
Sbjct: 525 WCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS- 583
Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264
D ++LW I+ + V ++ H D+V L + ++ D + LW+
Sbjct: 584 DGLVKLWTIKNNECVRT---LDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 4/83 (4%)
Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243
K + G+ + +++F + + ++ S L+++ +QT + GH D VL+ D
Sbjct: 328 KQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQIL----HGHTDIVLALD 383
Query: 244 YDLLGEKIMSCGMDHSLKLWRIN 266
G SC D S+++WR+N
Sbjct: 384 VFRKGWLFASCAKDQSVRIWRMN 406
Score = 38.1 bits (87), Expect = 0.016
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 4/89 (4%)
Query: 177 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHR 236
PI +Q H IN + P D LL + S+D +LW + L+ +F GHR
Sbjct: 466 PILLQAQTTQRCHDKDINSVAIAPND-KLLATGSQDRTAKLWALPQCQLLGVF---SGHR 521
Query: 237 DEVLSADYDLLGEKIMSCGMDHSLKLWRI 265
+ + + + + + D ++KLW +
Sbjct: 522 RGLWCVQFSPMDQVLATASADGTIKLWAL 550
Score = 31.2 bits (69), Expect = 2.0
Identities = 62/290 (21%), Positives = 105/290 (36%), Gaps = 52/290 (17%)
Query: 111 LVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRG 170
+V + + LYE S + Y + D F SH + VA +
Sbjct: 306 VVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFL------GPEDSH--VVVASNSP 357
Query: 171 IIRIINPITMQC-IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229
+++ T C I H GH + + L R L S +KD ++R+W + V
Sbjct: 358 CLKVFELQTSACQILH--GHTDIVLALDVF-RKGWLFASCAKDQSVRIWRMNKAGQVMCV 414
Query: 230 GGVEGHRDEVLSADYDLLGEKIMSCG-MDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288
GH V + L E + G D ++KLW + K N N P
Sbjct: 415 AQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP--------KALLSKNTAPDNGP 466
Query: 289 FI-----SQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKI 343
+ +Q+ H D ++ I N L+ + S + W + +
Sbjct: 467 ILLQAQTTQRCHDKDINSVAIAPN--------DKLLATGSQDRTAKLWALPQCQ------ 512
Query: 344 KPSESNVTILGRFDYSQCDIWYMRFS-MDFWQKMLALGNQVGKLYVWDLE 392
+LG F + +W ++FS MD ++LA + G + +W L+
Sbjct: 513 --------LLGVFSGHRRGLWCVQFSPMD---QVLATASADGTIKLWALQ 551
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/284 (20%), Positives = 110/284 (38%), Gaps = 60/284 (21%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
++ S +R+ + T + + + H A+ L+F+ ++++ SKD ++ +W++
Sbjct: 319 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN---GMMVTCSKDRSIAVWDMA 375
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281
+ T + + + GHR V D+D + I+S D ++K+W ++ + +
Sbjct: 376 SPTDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNG----- 428
Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDID 341
H+ + C+++ L++S S +N I W
Sbjct: 429 -----------------------HKRGIACLQYRDRLVVSGSSDNTIRLWD--------- 456
Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE-DPHKAK 400
I+ + G + +C + F K + G GK+ VWDL DP
Sbjct: 457 -IECGACLRVLEGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDLVAALDPRAPA 507
Query: 401 CT----TLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440
T TL H G R D +++ D +I WD L
Sbjct: 508 GTLCLRTLVEHS-GRVFR---LQFDEFQIVSSSHDDTILIWDFL 547
Score = 33.5 bits (75), Expect = 0.40
Identities = 19/74 (25%), Positives = 39/74 (52%), Gaps = 7/74 (9%)
Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM-DHSL 260
D ++S +D+ +++W+ T I + GH VL YD E+++ G D ++
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRI---LTGHTGSVLCLQYD---ERVIITGSSDSTV 329
Query: 261 KLWRINSKRMMNAI 274
++W +N+ M+N +
Sbjct: 330 RVWDVNTGEMLNTL 343
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/284 (20%), Positives = 110/284 (38%), Gaps = 60/284 (21%)
Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221
++ S +R+ + T + + + H A+ L+F+ ++++ SKD ++ +W++
Sbjct: 355 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN---GMMVTCSKDRSIAVWDMA 411
Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281
+ T + + + GHR V D+D + I+S D ++K+W ++ + +
Sbjct: 412 SPTDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNG----- 464
Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDID 341
H+ + C+++ L++S S +N I W
Sbjct: 465 -----------------------HKRGIACLQYRDRLVVSGSSDNTIRLWD--------- 492
Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE-DPHKAK 400
I+ + G + +C + F K + G GK+ VWDL DP
Sbjct: 493 -IECGACLRVLEGHEELVRC--------IRFDNKRIVSGAYDGKIKVWDLVAALDPRAPA 543
Query: 401 CT----TLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440
T TL H G R D +++ D +I WD L
Sbjct: 544 GTLCLRTLVEHS-GRVFR---LQFDEFQIVSSSHDDTILIWDFL 583
Score = 33.5 bits (75), Expect = 0.40
Identities = 19/74 (25%), Positives = 39/74 (52%), Gaps = 7/74 (9%)
Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM-DHSL 260
D ++S +D+ +++W+ T I + GH VL YD E+++ G D ++
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRI---LTGHTGSVLCLQYD---ERVIITGSSDSTV 365
Query: 261 KLWRINSKRMMNAI 274
++W +N+ M+N +
Sbjct: 366 RVWDVNTGEMLNTL 379
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 48.1 bits (113), Expect = 2e-05
Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 4/77 (5%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247
GH A+ ++ + D LL+S S D L++W+++ L + GH DEV + D+
Sbjct: 120 GHVAAVYQIAWSA-DSRLLVSGSSDSTLKVWDVKAQKLAM---DLPGHADEVYAVDWSPD 175
Query: 248 GEKIMSCGMDHSLKLWR 264
G+++ S G D L++WR
Sbjct: 176 GQRVASGGKDKCLRIWR 192
Score = 38.9 bits (89), Expect = 0.009
Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 4/83 (4%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247
GH IN++ F P D ++ S S D +++LW+ +T +A + GH V +
Sbjct: 78 GHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKYLA---SLRGHVAAVYQIAWSAD 133
Query: 248 GEKIMSCGMDHSLKLWRINSKRM 270
++S D +LK+W + ++++
Sbjct: 134 SRLLVSGSSDSTLKVWDVKAQKL 156
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 48.1 bits (113), Expect = 2e-05
Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 4/77 (5%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247
GH A+ ++ + D LL+S S D L++W+++ L + GH DEV + D+
Sbjct: 412 GHVAAVYQIAWSA-DSRLLVSGSSDSTLKVWDVKAQKLAM---DLPGHADEVYAVDWSPD 467
Query: 248 GEKIMSCGMDHSLKLWR 264
G+++ S G D L++WR
Sbjct: 468 GQRVASGGKDKCLRIWR 484
Score = 42.7 bits (99), Expect = 7e-04
Identities = 73/306 (23%), Positives = 113/306 (36%), Gaps = 58/306 (18%)
Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240
+C GH A+ + F P L S S D +R W++ T+T +GHR VL
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTG-KYLASGSGDTTVRFWDLSTETPHFT---CKGHRHWVL 160
Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY-------DYNPNKTNRPFISQK 293
S + G K+ S + + LW ++ + + + + P N
Sbjct: 161 SISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVA 220
Query: 294 IHFPDFSTR-------------DIHRNYVDCVRWLGD-LILSKSCENAIVCWKP------ 333
D S R H V C+RW GD L+ S S + I W+
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLC 280
Query: 334 ----------GKMEDDID------KIKPSESNVT---ILGRFDYSQCDIWYMRFSMDFWQ 374
M D +P+E++V + G + + R+++ Q
Sbjct: 281 RTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELK-ERALSRYNLVRGQ 339
Query: 375 --KMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDA 432
+ L G+ L++W ED K T +T H+ A I Q FS DS I+ + D
Sbjct: 340 GPERLVSGSDDFTLFLWS-PAED--KKPLTRMTGHQ--ALINQVLFSPDSRIVASASFDK 394
Query: 433 SIWRWD 438
SI WD
Sbjct: 395 SIKLWD 400
Score = 38.9 bits (89), Expect = 0.009
Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 4/83 (4%)
Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247
GH IN++ F P D ++ S S D +++LW+ +T +A + GH V +
Sbjct: 370 GHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKYLA---SLRGHVAAVYQIAWSAD 425
Query: 248 GEKIMSCGMDHSLKLWRINSKRM 270
++S D +LK+W + ++++
Sbjct: 426 SRLLVSGSSDSTLKVWDVKAQKL 448
>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
Length = 323
Score = 47.4 bits (111), Expect = 3e-05
Identities = 41/182 (22%), Positives = 83/182 (45%), Gaps = 17/182 (9%)
Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYE-CHSQGEIRLLQSYVDADADENFYT 149
D N LF V + S+ + ++ G + L++ + G +++ + + + Y+
Sbjct: 65 DWNDGLFDVTW---SENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHA-----QEVYS 116
Query: 150 CAWTYDSNTSHPLLAVAGSRG-IIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS 208
W S T L V+GS +++ +P + + + GH + I + P P S
Sbjct: 117 VDW---SQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFAS 173
Query: 209 VSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCG-MDHSLKLWRINS 267
S D LR+W+++ + + + H+ E+LS D+ E ++ G +D SL+ W + +
Sbjct: 174 ASGDQTLRIWDVKAAGVRIV---IPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRN 230
Query: 268 KR 269
R
Sbjct: 231 VR 232
Score = 40.4 bits (93), Expect = 0.003
Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 5/85 (5%)
Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGGVEGHRDEV 239
Q + +GH AI +KF P ++L S S D +R WN + D+L+ VE H +
Sbjct: 233 QPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLET---VEHHTEFT 289
Query: 240 LSADYDLLG-EKIMSCGMDHSLKLW 263
D+ L ++ C D ++K++
Sbjct: 290 CGLDFSLQSPTQVADCSWDETIKIY 314
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 47.4 bits (111), Expect = 3e-05
Identities = 36/144 (25%), Positives = 70/144 (48%), Gaps = 13/144 (9%)
Query: 153 TYDSN-----TSHPLLAVAGSRGIIRIINPITMQCIK-HYVGHGNAINELKFHPRDPNLL 206
T+D N + L+AV+ +R I +++ I ++ I + GH ++ L F + N L
Sbjct: 411 TWDQNRVIHYSGGDLIAVSSNRKI-HLLDIIQVKAIPVEFRGHAGSVRAL-FLCEEENFL 468
Query: 207 LSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266
LS S D ++R W++++ IFGG +G DL +++S G D +K+W ++
Sbjct: 469 LSGSYDLSIRYWDLKSGVCTRIFGGHQG-----TITCMDLCKNRLVSGGRDCQVKVWDVD 523
Query: 267 SKRMMNAIKESYDYNPNKTNRPFI 290
+ + + + + N +I
Sbjct: 524 TGKCLKTFRHKDPILATRINDTYI 547
Score = 29.3 bits (64), Expect = 7.5
Identities = 28/109 (25%), Positives = 50/109 (45%), Gaps = 11/109 (10%)
Query: 169 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI--QTDTLV 226
RG++++ + Q +K GH A+ L F D LLS S D + W++ + + +
Sbjct: 553 RGLVKVWHIAMAQLVKTLSGHEGAVKCLFF---DQWHLLSGSTDGLVMAWSMVGKYERCL 609
Query: 227 AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275
F H EVL D LL +++S D ++++ + M +K
Sbjct: 610 MAF----KHPKEVL--DVSLLFLRVISACADGKIRIYNFLNGNCMKVLK 652
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 47.4 bits (111), Expect = 3e-05
Identities = 36/144 (25%), Positives = 70/144 (48%), Gaps = 13/144 (9%)
Query: 153 TYDSN-----TSHPLLAVAGSRGIIRIINPITMQCIK-HYVGHGNAINELKFHPRDPNLL 206
T+D N + L+AV+ +R I +++ I ++ I + GH ++ L F + N L
Sbjct: 411 TWDQNRVIHYSGGDLIAVSSNRKI-HLLDIIQVKAIPVEFRGHAGSVRAL-FLCEEENFL 468
Query: 207 LSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266
LS S D ++R W++++ IFGG +G DL +++S G D +K+W ++
Sbjct: 469 LSGSYDLSIRYWDLKSGVCTRIFGGHQG-----TITCMDLCKNRLVSGGRDCQVKVWDVD 523
Query: 267 SKRMMNAIKESYDYNPNKTNRPFI 290
+ + + + + N +I
Sbjct: 524 TGKCLKTFRHKDPILATRINDTYI 547
Score = 30.0 bits (66), Expect = 4.4
Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 11/109 (10%)
Query: 169 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI--QTDTLV 226
RG++++ + Q +K GH A+ L F D LLS S D + W++ + + +
Sbjct: 553 RGLVKVWHIAMAQLVKTLSGHEGAVKCLFF---DQWHLLSGSTDGLVMAWSMVGKYERCL 609
Query: 227 AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275
F H EVL D LL +++S D ++++ + M IK
Sbjct: 610 MAF----KHPKEVL--DVSLLFLRVISACADGKIRIYNFFNGNCMKVIK 652
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 46.6 bits (109), Expect = 5e-05
Identities = 31/104 (29%), Positives = 50/104 (48%), Gaps = 15/104 (14%)
Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE--------GHRDEVL 240
H + + L FHP +P +L++ S+DH L+LWN+Q ++ H VL
Sbjct: 479 HFDGVRALAFHPVEP-VLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVL 537
Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD-YNPN 283
S GE+ S G+D +++ W + S + + YD Y PN
Sbjct: 538 SLAISSNGEQCFSGGIDATIQWWNMPSPSV-----DPYDTYEPN 576
Score = 35.0 bits (79), Expect = 0.14
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 4/84 (4%)
Query: 191 NAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEK 250
N IN + HP P + ++ +D ++ ++ +T ++ + H D V S D G
Sbjct: 682 NHINRVVSHPTLP-VTITAHEDRHIKFFDNKTGKMIH---SMVAHLDAVTSLAVDPNGIY 737
Query: 251 IMSCGMDHSLKLWRINSKRMMNAI 274
+MS D S++LW ++SK + I
Sbjct: 738 LMSGSHDCSIRLWNLDSKTCVQEI 761
Score = 30.4 bits (67), Expect = 3.3
Identities = 15/65 (23%), Positives = 30/65 (46%), Gaps = 8/65 (12%)
Query: 212 DHALRLWNIQTDTLV--------AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263
D ++ WN+ + ++ + G + GH D V Y + +++SC D +++LW
Sbjct: 554 DATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLW 613
Query: 264 RINSK 268
K
Sbjct: 614 NPQEK 618
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,032,518
Number of Sequences: 37866
Number of extensions: 819760
Number of successful extensions: 3440
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 133
Number of HSP's that attempted gapping in prelim test: 2735
Number of HSP's gapped (non-prelim): 724
length of query: 441
length of database: 18,247,518
effective HSP length: 105
effective length of query: 336
effective length of database: 14,271,588
effective search space: 4795253568
effective search space used: 4795253568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.