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Search of human proteins with 119943106
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
(817 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 1665 0.0
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 1072 0.0
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 1047 0.0
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 1036 0.0
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 1004 0.0
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 1004 0.0
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 958 0.0
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 956 0.0
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 823 0.0
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 553 e-157
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 200 5e-51
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 194 4e-49
gi|95089461 discs large homolog 5 [Homo sapiens] 192 1e-48
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 181 2e-45
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 174 4e-43
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 171 3e-42
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 171 3e-42
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 168 2e-41
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 168 2e-41
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 162 1e-39
gi|45827729 scribble isoform b [Homo sapiens] 148 2e-35
gi|45827731 scribble isoform a [Homo sapiens] 148 2e-35
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 140 5e-33
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 140 5e-33
gi|10092691 tight junction protein 3 [Homo sapiens] 133 8e-31
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 129 1e-29
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 128 2e-29
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 128 2e-29
gi|148746189 multiple PDZ domain protein [Homo sapiens] 125 1e-28
gi|112382257 InaD-like [Homo sapiens] 122 2e-27
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 1665 bits (4311), Expect = 0.0
Identities = 817/817 (100%), Positives = 817/817 (100%)
Query: 1 MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGGNGASAGYGGYSSQTLP 60
MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGGNGASAGYGGYSSQTLP
Sbjct: 1 MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGGNGASAGYGGYSSQTLP 60
Query: 61 SQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQV 120
SQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQV
Sbjct: 61 SQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQV 120
Query: 121 NGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVN 180
NGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVN
Sbjct: 121 NGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVN 180
Query: 181 DCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSI 240
DCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSI
Sbjct: 181 DCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSI 240
Query: 241 AGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKN 300
AGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKN
Sbjct: 241 AGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKN 300
Query: 301 TSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPP 360
TSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPP
Sbjct: 301 TSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPP 360
Query: 361 QVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPA 420
QVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPA
Sbjct: 361 QVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPA 420
Query: 421 DLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDL 480
DLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDL
Sbjct: 421 DLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDL 480
Query: 481 REQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASD 540
REQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASD
Sbjct: 481 REQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASD 540
Query: 541 DEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDY 600
DEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDY
Sbjct: 541 DEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDY 600
Query: 601 YGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTT 660
YGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTT
Sbjct: 601 YGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTT 660
Query: 661 RPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCI 720
RPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCI
Sbjct: 661 RPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCI 720
Query: 721 LDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEY 780
LDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEY
Sbjct: 721 LDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEY 780
Query: 781 FTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
FTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL
Sbjct: 781 FTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 1072 bits (2773), Expect = 0.0
Identities = 530/733 (72%), Positives = 622/733 (84%), Gaps = 30/733 (4%)
Query: 108 ECTCTNRDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIP 167
+C + + VNG++ +++EEI LERGNSGLGFSIAGG DNPH+ DDPGIFITKIIP
Sbjct: 24 QCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 83
Query: 168 GGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEV 227
GGAAA DGRL VNDC+LRVNEVDVSEV HS+AVEALKEAG +VRL VRRR+P ET++E+
Sbjct: 84 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 143
Query: 228 NLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQ 287
L KGPKGLGFSIAGG+GNQHIPGDNSIY+TKII+GGAAQKDGRLQ+GDRLL VNN +L+
Sbjct: 144 KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203
Query: 288 DVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYL 347
+V HEEAVA LKNTS++VYLKV KP ++++ D Y PPD +++ +NH+ ++
Sbjct: 204 EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN---- 259
Query: 348 GAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTR-----------------------EP 384
G +E K S P + P RYSPIP+HML ++D+T EP
Sbjct: 260 GTLEYKTSLPP---ISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEP 316
Query: 385 RKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444
RK++LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR A+
Sbjct: 317 RKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 376
Query: 445 HEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSL 504
HEQAAAALK AGQ+VTI+AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KRSL
Sbjct: 377 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 436
Query: 505 YVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSK 564
YVRA+FDYD+++DS LPSQGLSF YGDILHVINASDDEWWQAR V G+SE++GVIPSK
Sbjct: 437 YVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSK 496
Query: 565 KRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEI 624
+RVE+KERARLKTVKF+A+ G+I+S D PGL DD YG K L+GQED ILSYEPVTRQEI
Sbjct: 497 RRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEI 556
Query: 625 HYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 684
+Y RPVIILGPMKDR+NDDLISEFP KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEK
Sbjct: 557 NYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 616
Query: 685 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 744
DIQ++KFIEAGQ+NDNLYGTS+QSVR VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIK
Sbjct: 617 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 676
Query: 745 PKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQ 804
P+S+E LMEMN+R T EQA K YD+A+KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+Q
Sbjct: 677 PRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQ 736
Query: 805 SGHYIWVPSPEKL 817
SG +IW+PS EKL
Sbjct: 737 SGPFIWIPSKEKL 749
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 1047 bits (2708), Expect = 0.0
Identities = 533/767 (69%), Positives = 632/767 (82%), Gaps = 25/767 (3%)
Query: 61 SQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQ- 119
S + +P T+A ++P+ V +P PVP ++T L + P P N D E
Sbjct: 153 SHSHISPIKPTEA-VLPSPPTVPVIPVLPVPAENTVILP-TIPQANPPPVLVNTDSLETP 210
Query: 120 --VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRL 177
VNG+D ++YEEI LERGNSGLGFSIAGG DNPH+ DD IFITKII GGAAA DGRL
Sbjct: 211 TYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRL 270
Query: 178 GVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLG 237
VNDC+LRVNEVDV +V HS+AVEALKEAG +VRL V+RR+P E IME+ L+KGPKGLG
Sbjct: 271 RVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLG 330
Query: 238 FSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVAS 297
FSIAGG+GNQHIPGDNSIY+TKIIEGGAA KDG+LQIGD+LLAVNN L++V HEEAV +
Sbjct: 331 FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTA 390
Query: 298 LKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYP 357
LKNTSD VYLKVAKP S+++ND YAPPD ++ + DNH+S +S LG A
Sbjct: 391 LKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPA-------- 442
Query: 358 APPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAG 417
P RYSP+ + +L +++ TREPRK++LH+GSTGLGFNIVGGEDGEGIF+SFILAG
Sbjct: 443 -----SPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497
Query: 418 GPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKI 477
GPADLSGELR+GDRI+SVN V+LR A+HEQAAAALK AGQ+VTIVAQYRPEEYSRFE+KI
Sbjct: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKI 557
Query: 478 HDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN 537
HDLREQMMNSS+SSGSGSLRTS+KRSLYVRALFDYD+T+DS LPSQGL+F +GDILHVIN
Sbjct: 558 HDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVIN 617
Query: 538 ASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHART---GMIESNRDFP 594
ASDDEWWQAR VTP GES+++GVIPSK+RVEKKERARLKTVKF+++T G I +
Sbjct: 618 ASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSK 677
Query: 595 GL----SDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPH 650
GL S+ + +GQE+ +LSYEPV +QE++Y RPVIILGPMKDR+NDDLISEFP
Sbjct: 678 GLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPD 737
Query: 651 KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVR 710
KFGSCVPHTTRP+RD EVDG+DYHFV SREQMEKDIQ++KFIEAGQ+N++LYGTS+QSVR
Sbjct: 738 KFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVR 797
Query: 711 AVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKA 770
VAE+GKHCILDVSGNAIKRLQ AQLYPI+IFIKPKS+E +MEMN+R T EQA K +++A
Sbjct: 798 EVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERA 857
Query: 771 MKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
MKLEQEF E+FTAIVQGD+LE+IYN++KQIIE+QSG YIWVP+ EKL
Sbjct: 858 MKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 1036 bits (2680), Expect = 0.0
Identities = 534/789 (67%), Positives = 634/789 (80%), Gaps = 47/789 (5%)
Query: 61 SQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQ- 119
S + +P T+A ++P+ V +P PVP ++T L + P P N D E
Sbjct: 153 SHSHISPIKPTEA-VLPSPPTVPVIPVLPVPAENTVILP-TIPQANPPPVLVNTDSLETP 210
Query: 120 --VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRL 177
VNG+D ++YEEI LERGNSGLGFSIAGG DNPH+ DD IFITKII GGAAA DGRL
Sbjct: 211 TYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRL 270
Query: 178 GVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLG 237
VNDC+LRVNEVDV +V HS+AVEALKEAG +VRL V+RR+P E IME+ L+KGPKGLG
Sbjct: 271 RVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLG 330
Query: 238 FSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVAS 297
FSIAGG+GNQHIPGDNSIY+TKIIEGGAA KDG+LQIGD+LLAVNN L++V HEEAV +
Sbjct: 331 FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTA 390
Query: 298 LKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYP 357
LKNTSD VYLKVAKP S+++ND YAPPD ++ + DNH+S +S LG A
Sbjct: 391 LKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPA-------- 442
Query: 358 APPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAG 417
P RYSP+ + +L +++ TREPRK++LH+GSTGLGFNIVGGEDGEGIF+SFILAG
Sbjct: 443 -----SPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497
Query: 418 GPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKI 477
GPADLSGELR+GDRI+SVN V+LR A+HEQAAAALK AGQ+VTIVAQYRPEEYSRFE+KI
Sbjct: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKI 557
Query: 478 HDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN 537
HDLREQMMNSS+SSGSGSLRTS+KRSLYVRALFDYD+T+DS LPSQGL+F +GDILHVIN
Sbjct: 558 HDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVIN 617
Query: 538 ASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHART---GMIESN---- 590
ASDDEWWQAR VTP GES+++GVIPSK+RVEKKERARLKTVKF+++T G ++
Sbjct: 618 ASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKK 677
Query: 591 ----RDFPGLSD-----------DYYGAKNL-------KGQEDAILSYEPVTRQEIHYAR 628
R FP + D + N +GQE+ +LSYEPV +QE++Y R
Sbjct: 678 NLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTR 737
Query: 629 PVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQD 688
PVIILGPMKDR+NDDLISEFP KFGSCVPHTTRP+RD EVDG+DYHFV SREQMEKDIQ+
Sbjct: 738 PVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQE 797
Query: 689 NKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSI 748
+KFIEAGQ+N++LYGTS+QSVR VAE+GKHCILDVSGNAIKRLQ AQLYPI+IFIKPKS+
Sbjct: 798 HKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSM 857
Query: 749 EALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHY 808
E +MEMN+R T EQA K +++AMKLEQEF E+FTAIVQGD+LE+IYN++KQIIE+QSG Y
Sbjct: 858 ENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSY 917
Query: 809 IWVPSPEKL 817
IWVP+ EKL
Sbjct: 918 IWVPAKEKL 926
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 1004 bits (2596), Expect = 0.0
Identities = 519/793 (65%), Positives = 611/793 (77%), Gaps = 94/793 (11%)
Query: 115 DWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD 174
D VNG++ +++EEI LERGNSGLGFSIAGG DNPH+ DDPGIFITKIIPGGAAA D
Sbjct: 187 DTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED 246
Query: 175 GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK 234
GRL VNDC+LRVNEVDVSEV HS+AVEALKEAG +VRL VRRR+P ET++E+ L KGPK
Sbjct: 247 GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK 306
Query: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294
GLGFSIAGG+GNQHIPGDNSIY+TKII+GGAAQKDGRLQ+GDRLL VNN +L++V HEEA
Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366
Query: 295 VASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKV 354
VA LKNTS++VYLKV KP ++++ D Y PPD +++ +NH+ ++ G +E K
Sbjct: 367 VAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN----GTLEYKT 422
Query: 355 S---------------------YPAPPQ-------------VPPTRYSPIPRH------- 373
S Y PP+ P YSP+
Sbjct: 423 SLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSA 482
Query: 374 --------MLAEEDFTR-----------------------EPRKIILHKGSTGLGFNIVG 402
+L + + T EPRK++LHKGSTGLGFNIVG
Sbjct: 483 PYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVG 542
Query: 403 GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
GEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR A+HEQAAAALK AGQ+VTI+
Sbjct: 543 GEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 602
Query: 463 AQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPS 522
AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KRSLYVRA+FDYD+++DS LPS
Sbjct: 603 AQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPS 662
Query: 523 QGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA 582
QGLSF YGDILHVINASDDEWWQAR V G+SE++GVIPSK+RVE+KERARLKTVKF+A
Sbjct: 663 QGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNA 722
Query: 583 RTGMIES--------------NRDFPGLSDDYYGAKNL----KGQEDAILSYEPVTRQEI 624
+ G+I+S +R FP + + +GQED ILSYEPVTRQEI
Sbjct: 723 KPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEI 782
Query: 625 HYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 684
+Y RPVIILGPMKDR+NDDLISEFP KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEK
Sbjct: 783 NYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 842
Query: 685 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 744
DIQ++KFIEAGQ+NDNLYGTS+QSVR VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIK
Sbjct: 843 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 902
Query: 745 PKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQ 804
P+S+E LMEMN+R T EQA K YD+A+KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+Q
Sbjct: 903 PRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQ 962
Query: 805 SGHYIWVPSPEKL 817
SG +IW+PS EKL
Sbjct: 963 SGPFIWIPSKEKL 975
Score = 70.9 bits (172), Expect = 5e-12
Identities = 57/192 (29%), Positives = 89/192 (46%), Gaps = 22/192 (11%)
Query: 337 HISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEE----------DFTREPRK 386
H+S + L +E+ Y + P + SP P + + + E +
Sbjct: 148 HVSEKN----LSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEE 203
Query: 387 IILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
I L +G++GLGF+I GG D GIF++ I+ GG A G LR D IL VN V++
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 441 RNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTS 499
+H +A ALK AG V + V + RP + E K+ + + S++ G G+
Sbjct: 264 SEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIP 322
Query: 500 EKRSLYVRALFD 511
S+YV + D
Sbjct: 323 GDNSIYVTKIID 334
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 1004 bits (2596), Expect = 0.0
Identities = 519/793 (65%), Positives = 611/793 (77%), Gaps = 94/793 (11%)
Query: 115 DWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD 174
D VNG++ +++EEI LERGNSGLGFSIAGG DNPH+ DDPGIFITKIIPGGAAA D
Sbjct: 82 DTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED 141
Query: 175 GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK 234
GRL VNDC+LRVNEVDVSEV HS+AVEALKEAG +VRL VRRR+P ET++E+ L KGPK
Sbjct: 142 GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK 201
Query: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294
GLGFSIAGG+GNQHIPGDNSIY+TKII+GGAAQKDGRLQ+GDRLL VNN +L++V HEEA
Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261
Query: 295 VASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKV 354
VA LKNTS++VYLKV KP ++++ D Y PPD +++ +NH+ ++ G +E K
Sbjct: 262 VAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN----GTLEYKT 317
Query: 355 S---------------------YPAPPQ-------------VPPTRYSPIPRH------- 373
S Y PP+ P YSP+
Sbjct: 318 SLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSA 377
Query: 374 --------MLAEEDFTR-----------------------EPRKIILHKGSTGLGFNIVG 402
+L + + T EPRK++LHKGSTGLGFNIVG
Sbjct: 378 PYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVG 437
Query: 403 GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
GEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR A+HEQAAAALK AGQ+VTI+
Sbjct: 438 GEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 497
Query: 463 AQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPS 522
AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KRSLYVRA+FDYD+++DS LPS
Sbjct: 498 AQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPS 557
Query: 523 QGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA 582
QGLSF YGDILHVINASDDEWWQAR V G+SE++GVIPSK+RVE+KERARLKTVKF+A
Sbjct: 558 QGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNA 617
Query: 583 RTGMIES--------------NRDFPGLSDDYYGAKNL----KGQEDAILSYEPVTRQEI 624
+ G+I+S +R FP + + +GQED ILSYEPVTRQEI
Sbjct: 618 KPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEI 677
Query: 625 HYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 684
+Y RPVIILGPMKDR+NDDLISEFP KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEK
Sbjct: 678 NYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 737
Query: 685 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 744
DIQ++KFIEAGQ+NDNLYGTS+QSVR VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIK
Sbjct: 738 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 797
Query: 745 PKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQ 804
P+S+E LMEMN+R T EQA K YD+A+KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+Q
Sbjct: 798 PRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQ 857
Query: 805 SGHYIWVPSPEKL 817
SG +IW+PS EKL
Sbjct: 858 SGPFIWIPSKEKL 870
Score = 70.9 bits (172), Expect = 5e-12
Identities = 57/192 (29%), Positives = 89/192 (46%), Gaps = 22/192 (11%)
Query: 337 HISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEE----------DFTREPRK 386
H+S + L +E+ Y + P + SP P + + + E +
Sbjct: 43 HVSEKN----LSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEE 98
Query: 387 IILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
I L +G++GLGF+I GG D GIF++ I+ GG A G LR D IL VN V++
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 441 RNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTS 499
+H +A ALK AG V + V + RP + E K+ + + S++ G G+
Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIP 217
Query: 500 EKRSLYVRALFD 511
S+YV + D
Sbjct: 218 GDNSIYVTKIID 229
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 958 bits (2477), Expect = 0.0
Identities = 470/700 (67%), Positives = 572/700 (81%), Gaps = 29/700 (4%)
Query: 119 QVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLG 178
QVNG++G +YEEI LERGNSGLGFSIAGG DNPH+ DDP IFITKIIPGGAAA DGRL
Sbjct: 96 QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155
Query: 179 VNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGF 238
VND +L VNEVDV EV HS AVEALKEAG +VRL V RR+PP E +ME+ L+KGPKGLGF
Sbjct: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGF 215
Query: 239 SIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASL 298
SIAGG+GNQHIPGDNSIY+TKIIEGGAA KDGRLQIGD++LAVN+ L+DV HE+AVA+L
Sbjct: 216 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAAL 275
Query: 299 KNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYP- 357
KNT D+VYLKVAKP + +L+D YAPPD ++++ DN ISH+S LG YP
Sbjct: 276 KNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG--------TDYPT 327
Query: 358 APPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAG 417
A P RYSP+ + +L EED REPR+I++H+GSTGLGFNIVGGEDGEGIF+SFILAG
Sbjct: 328 AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAG 387
Query: 418 GPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKI 477
GPADLSGELR+GD+ILSVNGV+LRNA+HEQAA ALK AGQ+VTI+AQY+PEEYSRFE+KI
Sbjct: 388 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKI 447
Query: 478 HDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN 537
HDLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYD+T+D SQ LSF +GD+LHVI+
Sbjct: 448 HDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVID 507
Query: 538 ASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLS 597
ASD+EWWQAR V E++ IG IPSK+RVE++E +RLK +
Sbjct: 508 ASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLK--------------------A 547
Query: 598 DDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP 657
D+ + +G+ED++LSYE VT+ E+HYARP+IILGP KDR NDDL+SEFP KFGSCVP
Sbjct: 548 KDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP 607
Query: 658 HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGK 717
HTTRP+R+ E+DG+DYHFV SRE+MEKDIQ +KFIEAGQ+N +LYGTS+QSVR VAE+GK
Sbjct: 608 HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGK 667
Query: 718 HCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEF 777
HCILDVS NA++RLQ A L+PIAIFI+P+S+E ++E+N+R T EQA K +D+A KLEQEF
Sbjct: 668 HCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEF 727
Query: 778 GEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
E F+AIV+GDS EEIY+K+K++IED SG YIWVP+ E+L
Sbjct: 728 TECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 956 bits (2472), Expect = 0.0
Identities = 469/699 (67%), Positives = 571/699 (81%), Gaps = 29/699 (4%)
Query: 120 VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGV 179
VNG++G +YEEI LERGNSGLGFSIAGG DNPH+ DDP IFITKIIPGGAAA DGRL V
Sbjct: 51 VNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRV 110
Query: 180 NDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFS 239
ND +L VNEVDV EV HS AVEALKEAG +VRL V RR+PP E +ME+ L+KGPKGLGFS
Sbjct: 111 NDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFS 170
Query: 240 IAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLK 299
IAGG+GNQHIPGDNSIY+TKIIEGGAA KDGRLQIGD++LAVN+ L+DV HE+AVA+LK
Sbjct: 171 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALK 230
Query: 300 NTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYP-A 358
NT D+VYLKVAKP + +L+D YAPPD ++++ DN ISH+S LG YP A
Sbjct: 231 NTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG--------TDYPTA 282
Query: 359 PPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGG 418
P RYSP+ + +L EED REPR+I++H+GSTGLGFNIVGGEDGEGIF+SFILAGG
Sbjct: 283 MTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGG 342
Query: 419 PADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIH 478
PADLSGELR+GD+ILSVNGV+LRNA+HEQAA ALK AGQ+VTI+AQY+PEEYSRFE+KIH
Sbjct: 343 PADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIH 402
Query: 479 DLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINA 538
DLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYD+T+D SQ LSF +GD+LHVI+A
Sbjct: 403 DLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDA 462
Query: 539 SDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSD 598
SD+EWWQAR V E++ IG IPSK+RVE++E +RLK +
Sbjct: 463 SDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLK--------------------AK 502
Query: 599 DYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPH 658
D+ + +G+ED++LSYE VT+ E+HYARP+IILGP KDR NDDL+SEFP KFGSCVPH
Sbjct: 503 DWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPH 562
Query: 659 TTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKH 718
TTRP+R+ E+DG+DYHFV SRE+MEKDIQ +KFIEAGQ+N +LYGTS+QSVR VAE+GKH
Sbjct: 563 TTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKH 622
Query: 719 CILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFG 778
CILDVS NA++RLQ A L+PIAIFI+P+S+E ++E+N+R T EQA K +D+A KLEQEF
Sbjct: 623 CILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFT 682
Query: 779 EYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
E F+AIV+GDS EEIY+K+K++IED SG YIWVP+ E+L
Sbjct: 683 ECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 823 bits (2126), Expect = 0.0
Identities = 424/468 (90%), Positives = 430/468 (91%), Gaps = 32/468 (6%)
Query: 382 REPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
REPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR
Sbjct: 45 REPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 104
Query: 442 NATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK 501
NATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK
Sbjct: 105 NATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK 164
Query: 502 RSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVI 561
RSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVI
Sbjct: 165 RSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVI 224
Query: 562 PSKKRVEKKERARLKTVKFHARTGMIESNRD--------------FP------------- 594
PSKKRVEKKERARLKTVKFHARTGMIESNR FP
Sbjct: 225 PSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESS 284
Query: 595 ----GLSDDYYGAKNL-KGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFP 649
G++ + +++ KGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFP
Sbjct: 285 IQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFP 344
Query: 650 HKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSV 709
HKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSV
Sbjct: 345 HKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSV 404
Query: 710 RAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDK 769
RAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDK
Sbjct: 405 RAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDK 464
Query: 770 AMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
AMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL
Sbjct: 465 AMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 512
Score = 65.1 bits (157), Expect = 3e-10
Identities = 42/133 (31%), Positives = 69/133 (51%), Gaps = 8/133 (6%)
Query: 131 EIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVD 190
+I+L +G++GLGF+I GG D GIF++ I+ GG A + G L D +L VN V+
Sbjct: 49 KIILHKGSTGLGFNIVGG------EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVN 102
Query: 191 VSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLK-GPKGLGFSIAGGIGNQHI 249
+ H +A ALK AG V +V + R P + E + + + S++ G G+
Sbjct: 103 LRNATHEQAAAALKRAGQSVTIVAQYR-PEEYSRFESKIHDLREQMMNSSMSSGSGSLRT 161
Query: 250 PGDNSIYITKIIE 262
S+Y+ + +
Sbjct: 162 SEKRSLYVRALFD 174
Score = 60.8 bits (146), Expect = 5e-09
Identities = 32/80 (40%), Positives = 47/80 (58%), Gaps = 6/80 (7%)
Query: 226 EVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTN 285
++ L KG GLGF+I GG + I+++ I+ GG A G L+ GDR+L+VN N
Sbjct: 49 KIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVN 102
Query: 286 LQDVRHEEAVASLKNTSDMV 305
L++ HE+A A+LK V
Sbjct: 103 LRNATHEQAAAALKRAGQSV 122
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 553 bits (1424), Expect = e-157
Identities = 267/334 (79%), Positives = 304/334 (91%)
Query: 484 MMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEW 543
MMN SMSSGSGSLRT++KRSLYVRA+FDYD+++DS LPSQGLSF YGDILHVINASDDEW
Sbjct: 1 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 60
Query: 544 WQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGA 603
WQAR V G+SE++GVIPSK+RVE+KERARLKTVKF+A+ G+I+S D PGL DD YG
Sbjct: 61 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGT 120
Query: 604 KNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPR 663
K L+GQED ILSYEPVTRQEI+Y RPVIILGPMKDR+NDDLISEFP KFGSCVPHTTRP+
Sbjct: 121 KTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK 180
Query: 664 RDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDV 723
RD EVDG+DYHFV+SREQMEKDIQ++KFIEAGQ+NDNLYGTS+QSVR VAERGKHCILDV
Sbjct: 181 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 240
Query: 724 SGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTA 783
SGNAIKRLQ AQLYPIAIFIKP+S+E LMEMN+R T EQA K YD+A+KLEQEFGEYFTA
Sbjct: 241 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTA 300
Query: 784 IVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
IVQGD+LE+IYN+ K +IE+QSG +IW+PS EKL
Sbjct: 301 IVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 334
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 200 bits (508), Expect = 5e-51
Identities = 134/422 (31%), Positives = 209/422 (49%), Gaps = 41/422 (9%)
Query: 407 EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYR 466
+ + +S I+ GG A+ SG L GD +L +NG+ +R + L ++T V
Sbjct: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVL--- 332
Query: 467 PEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--G 524
+ S +++ ++V+A FDYD + D +P + G
Sbjct: 333 ----------------------IPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELG 370
Query: 525 LSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERAR--LKTVKFHA 582
LSF GDILHVI+ D WWQA G++P K +++E + ++ K
Sbjct: 371 LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPE 430
Query: 583 RTGMIE-SNRDFPGLSDDYYGA-KNLKGQEDAILSYEPVT--RQEIHYARPVIILGPM-- 636
++G + + ++ Y A KN + IL+YE ++ Q + RP+I++GP
Sbjct: 431 KSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNC 490
Query: 637 -KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAG 695
++ + L+++ +F S VPHTTR RRD EV G+DYHFV SR+ E DI KFIE G
Sbjct: 491 GQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFV-SRQAFEADIAAGKFIEHG 549
Query: 696 QFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEM- 754
+F NLYGTSI SVR V GK C+L + ++K L+ + L P IFI P S E L +
Sbjct: 550 EFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALL 609
Query: 755 ---NRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWV 811
+ E+ +I +K ++EQ G YF + L++ Y ++ ++I WV
Sbjct: 610 AKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWV 669
Query: 812 PS 813
PS
Sbjct: 670 PS 671
Score = 35.8 bits (81), Expect = 0.16
Identities = 14/35 (40%), Positives = 25/35 (71%)
Query: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQ 287
+S+ I++I++GGAA+K G L GD +L +N ++
Sbjct: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 194 bits (492), Expect = 4e-49
Identities = 163/547 (29%), Positives = 243/547 (44%), Gaps = 82/547 (14%)
Query: 315 LHLNDMYAPPDYASTFTALADNHISH------NSSLGYLGAVESKVSYPAPPQVPPT--- 365
LH + +P ALAD+ NS + L + SK + A V T
Sbjct: 57 LHYYEKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQ 116
Query: 366 -RYSPIPRHMLAEEDFTREPRKII-LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLS 423
Y P+ M + D + KII L K LG I E I V+ I+ GG AD S
Sbjct: 117 KNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRS 176
Query: 424 GELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQ 483
G + GD + VNG+ + + E+ L ++ ++T
Sbjct: 177 GLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITF---------------------- 214
Query: 484 MMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFSYGDILHVINASDD 541
+ GS S++ ++++ALFDY+ D +P + GLSF GDIL +++ D
Sbjct: 215 ----KIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDA 270
Query: 542 EWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDY- 600
WWQA+ + + G+IPSK E++ R + + SNR G +
Sbjct: 271 TWWQAKHEAD--ANPRAGLIPSKHFQERRLALRRPEILVQP---LKVSNRKSSGFRKSFR 325
Query: 601 ------------YGAKNLKGQEDA-ILSYEPVT---RQEIHYARPVIILGPMKDRVNDD- 643
Y K + A + +YE VT RQ R V+++GP+ +N+
Sbjct: 326 LSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELK 385
Query: 644 ---LISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDN 700
LIS+ H +G VPHTTR RR E DG +Y F+ S+ E D+Q+NKFIE G++ +N
Sbjct: 386 RKLLISDTQH-YGVTVPHTTRARRSQESDGVEYIFI-SKHLFETDVQNNKFIEYGEYKNN 443
Query: 701 LYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQ-- 758
YGTSI SVR+V + K C+LDV + +K L+ + P IFIKP SIE L E +
Sbjct: 444 YYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKI 503
Query: 759 -------------TYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQS 805
T E ++ A +E ++G F I+ D L +N++K +
Sbjct: 504 ISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLE 563
Query: 806 GHYIWVP 812
WVP
Sbjct: 564 TETHWVP 570
Score = 44.3 bits (103), Expect = 5e-04
Identities = 31/136 (22%), Positives = 63/136 (46%), Gaps = 7/136 (5%)
Query: 179 VNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGF 238
+ + + +++ +V ++ A K PV+ + +++ + L+K + LG
Sbjct: 92 IRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGA 151
Query: 239 SIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASL 298
+I + +I + +I+ GGAA + G + +GD L VN ++D R EE + L
Sbjct: 152 TI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQIL 205
Query: 299 KNTSDMVYLKVAKPGS 314
+ + K+ PGS
Sbjct: 206 AQSQGAITFKII-PGS 220
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 192 bits (487), Expect = 1e-48
Identities = 163/634 (25%), Positives = 280/634 (44%), Gaps = 91/634 (14%)
Query: 215 RRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQI 274
R+ +P E V + KG + LG SI G IY++K+ G A + G L+
Sbjct: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSG-------EKGGIYVSKVTVGSIAHQAG-LEY 1390
Query: 275 GDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPP----DYASTF 330
GD+LL N NL+ ++A + D + + +H ++ D A T
Sbjct: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTH 1450
Query: 331 TALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILH 390
+ L S ++ + ++ + P PP + S R T EPR + +
Sbjct: 1451 STLQG---SGTTTPEHPSVIDPLMEQDEGPSTPPAKQSS-SRIAGDANKKTLEPRVVFIK 1506
Query: 391 KGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAA 450
K LG ++ GG + G+FV+ + PA L GD IL +++RN T E+
Sbjct: 1507 KSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYV 1565
Query: 451 ALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALF 510
+ + V + QYRPEE+++ + D S Y+RAL
Sbjct: 1566 EMLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYIRAL- 1601
Query: 511 DYDRTRDSCLPSQGLSFSYGDILHVINASDDEW---WQARLVTPHGESEQIGVIPSKKRV 567
YDR D Q LSF DIL+V + W A + + + Q G IPSK +
Sbjct: 1602 -YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVM 1657
Query: 568 EKKERARL------------KTVKFHARTGMIESNRDFPG---------LSDDYYGAKNL 606
+++ RL KT+ AR L+ D + + ++
Sbjct: 1658 DQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSI 1717
Query: 607 KGQEDAI-LSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRD 665
ED++ L+Y+ V + + RPV+ILGP+ D V + L++E P KF C +
Sbjct: 1718 PLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMK---- 1773
Query: 666 NEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSG 725
S++ +E+ ++D F++ + + + T++ S++ + E+ +HC+LD++
Sbjct: 1774 -----------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAP 1822
Query: 726 NAIKRLQQAQLYPIAIFIKPKSIEALME------MNRRQTYEQANKIYDKAMKLEQEFGE 779
+AI+RL +YPI IFI KS + + E + + T + + ++ A KLEQE+
Sbjct: 1823 HAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSR 1882
Query: 780 YFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 813
YFT ++QG +L I +I ++ + +W+P+
Sbjct: 1883 YFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
Score = 97.1 bits (240), Expect = 6e-20
Identities = 60/174 (34%), Positives = 93/174 (53%), Gaps = 17/174 (9%)
Query: 141 LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAV 200
LGF +A G++ P P D GIF+TK+ G A DGRL VND +LR+N+VD+ +A+
Sbjct: 635 LGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQAI 692
Query: 201 EALKEAGPVVRLVVRRRQP---PPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYI 257
+AL + +VVRRR+ T + +N L G K G S+ +N +Y
Sbjct: 693 KALLNGEGAINMVVRRRKSLGGKVVTPLHIN-LSGQKDSGISL-----------ENGVYA 740
Query: 258 TKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK 311
++ G A K+G L +GDR++A+N L + E + L++ D + L + K
Sbjct: 741 AAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLK 794
Score = 54.3 bits (129), Expect = 4e-07
Identities = 29/82 (35%), Positives = 48/82 (58%), Gaps = 2/82 (2%)
Query: 234 KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEE 293
K LGF +A G+ PGD I++TK+ +G A DGRL++ D LL +N+ +L + ++
Sbjct: 633 KALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQ 690
Query: 294 AVASLKNTSDMVYLKVAKPGSL 315
A+ +L N + + V + SL
Sbjct: 691 AIKALLNGEGAINMVVRRRKSL 712
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/82 (31%), Positives = 43/82 (52%), Gaps = 5/82 (6%)
Query: 385 RKIILHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
RK + K T L N+ G +D G++ + +L G PA G L GDRI+++NG+
Sbjct: 709 RKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
Query: 440 LRNATHEQAAAALKRAGQSVTI 461
L N + + + L+ S+T+
Sbjct: 769 LDNKSLNECESLLRSCQDSLTL 790
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 181 bits (460), Expect = 2e-45
Identities = 139/493 (28%), Positives = 235/493 (47%), Gaps = 82/493 (16%)
Query: 369 PIPRHMLAEEDFTREPRKII-LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELR 427
P+P ++ +EDF E KI+ L K LG I E + V+ I+ GG AD SG +
Sbjct: 121 PLPDNI--DEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVH 178
Query: 428 RGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRF-ESKIHDLREQMMN 486
GD + VNG+ + + ++ + L ++ S+T+ +E R ESK+
Sbjct: 179 VGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKV--------- 229
Query: 487 SSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWW 544
++RALF Y+ D +P Q GL F +L V++ D WW
Sbjct: 230 ------------------FMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWW 271
Query: 545 QARLVTPHGESE-QIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFP--------- 594
QA+ V G++ + G+IPSK E++ R + + + D P
Sbjct: 272 QAKRV---GDTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCE 328
Query: 595 GLSDDYYGA-----------KNLKGQEDA----------ILSYEPVTR---QEIHYARPV 630
G +Y A + L G ++ +L+YE V R Q R V
Sbjct: 329 GYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLV 388
Query: 631 IILGPMKDRVND---DLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQ 687
+++G + R+++ +++E P FG VPHTTRPR+ +E +G +YHFV S++ E D+
Sbjct: 389 VLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFV-SKQAFEADLH 447
Query: 688 DNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKP-- 745
NKF+E G++ +NLYGTS+++++AV + K C++DV A+K+L+ ++ P IF+KP
Sbjct: 448 HNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAI 507
Query: 746 ------KSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQ 799
+ E EQ ++ A +++ +G A++ + L+ Y+++K
Sbjct: 508 QEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKV 567
Query: 800 IIEDQSGHYIWVP 812
++E S WVP
Sbjct: 568 VLEKLSKDTHWVP 580
Score = 38.5 bits (88), Expect = 0.025
Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 6/88 (6%)
Query: 222 ETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAV 281
E++ V L+K + LG +I ++H ++ + +I+ GGAA + G + +GD L V
Sbjct: 133 ESVKIVRLVKNKEPLGATIRR---DEH---SGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 282 NNTNLQDVRHEEAVASLKNTSDMVYLKV 309
N + R +E L + + LK+
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKI 214
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 174 bits (440), Expect = 4e-43
Identities = 116/414 (28%), Positives = 205/414 (49%), Gaps = 24/414 (5%)
Query: 411 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVT--IVAQYRPE 468
V+ I+ GG G L GD I +NG+++ N T EQ L+ S+T IV YR +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574
Query: 469 EYSRFESKIHDLREQMMNSSMSSGSG-----SLRTSEKRSLYVRALFDYDRTRDSCLPSQ 523
S R+ N S+ + S + R +YVRA F+YD +D +P +
Sbjct: 575 SSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCK 634
Query: 524 --GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFH 581
G+ F GDI+ +I+ D WWQ +L + ++ G+IPS + E R+ +
Sbjct: 635 EAGIRFRVGDIIQIISKDDHNWWQGKL--ENSKNGTAGLIPSPELQEW----RVACIAME 688
Query: 582 ARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPM---KD 638
+++ + G Y K L +++YE V + + +++LG +
Sbjct: 689 KTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRR 748
Query: 639 RVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFN 698
+ + LI++ P +F +PHTTRP + +E +G++Y+FV S +QM +DI +N+++E G
Sbjct: 749 HIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGSHE 807
Query: 699 DNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQ 758
D +YGT ++++R + E+G ILDV A+K L+ A+ P +FI +I +N +
Sbjct: 808 DAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITP--GLNEDE 865
Query: 759 TYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVP 812
+ ++ K D L++ + YF + + ++E +++ +E WVP
Sbjct: 866 SLQRLQKESD---ILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 916
Score = 30.8 bits (68), Expect = 5.3
Identities = 22/96 (22%), Positives = 40/96 (41%), Gaps = 3/96 (3%)
Query: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKP 312
N + +I+ GG + G L +GD + +N ++ + E+ L+ + K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVP- 569
Query: 313 GSLHLNDMYAPPDYASTF-TALADNHISHNSSLGYL 347
S D ST + A+ H S N+S+ L
Sbjct: 570 -SYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDL 604
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 171 bits (433), Expect = 3e-42
Identities = 138/491 (28%), Positives = 219/491 (44%), Gaps = 61/491 (12%)
Query: 340 HNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFN 399
H SL + + Y +PP P S I +L + R + +HK + G
Sbjct: 88 HFQSLLEAHDIVASKCYDSPPSSPEMNNSSINNQLLPVDAI----RILGIHKRA-GEPLG 142
Query: 400 IVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSV 459
+ + + ++ IL GG D G L GD I VNG + N E LK SV
Sbjct: 143 VTFRVENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGNNPKE-LQELLKNISGSV 201
Query: 460 T--IVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRD 517
T I+ YR T + ++V+ FDY+ D
Sbjct: 202 TLKILPSYRD------------------------------TITPQQVFVKCHFDYNPYND 231
Query: 518 SCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKER-AR 574
+ +P + GL FS G+IL ++N D WWQA V G + G+IPS+ EK++ R
Sbjct: 232 NLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSA---GLIPSQFLEEKRKAFVR 288
Query: 575 LKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILG 634
G I S + + Y +N + I YE V + + ++++G
Sbjct: 289 RDWDNSGPFCGTISSKKKKKMM---YLTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIG 345
Query: 635 PM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKF 691
+ + + I P +FG+ VP T+R R++E DGQ Y FV SR +ME DI+ K+
Sbjct: 346 AQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFV-SRSEMEADIKAGKY 404
Query: 692 IEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEAL 751
+E G++ NLYGT I S+ V + G+ CILDV+ A+K L+ ++ P +FI +E L
Sbjct: 405 LEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETL 464
Query: 752 MEMNRR----------QTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQII 801
M++ T K D++ ++++ + YF I+ D+L++ + K++ I
Sbjct: 465 RAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAI 524
Query: 802 EDQSGHYIWVP 812
E WVP
Sbjct: 525 EKLRMEPQWVP 535
Score = 33.5 bits (75), Expect = 0.82
Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Query: 252 DNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
+N + I +I+ GG + G L +GD + VN + + +E LKN S V LK+
Sbjct: 149 NNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGN-NPKELQELLKNISGSVTLKI 205
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 171 bits (433), Expect = 3e-42
Identities = 126/440 (28%), Positives = 208/440 (47%), Gaps = 66/440 (15%)
Query: 395 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKR 454
G+ F + GGE + ++ IL GG G L GD I VNG Q + R
Sbjct: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNG---------QPVGSDPR 198
Query: 455 AGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK----RSLYVRALF 510
A L+E + N+S S L + ++ R ++V+ F
Sbjct: 199 A------------------------LQELLRNASGSVILKILPSYQEPHLPRQVFVKCHF 234
Query: 511 DYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVE 568
DYD RDS +P + GL F+ GD+L ++N D WWQA H E G+IPS+ E
Sbjct: 235 DYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQAC----HVEGGSAGLIPSQLLEE 290
Query: 569 KKERARLKTVKFHARTGMIESNRDFPGLSDD---YYGAKNLKGQEDAILSYEPVTRQEIH 625
K++ + ++ +G + + G Y KN + +L YE V R
Sbjct: 291 KRKAFVKRDLELTPNSGTLCGS--LSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPF 348
Query: 626 YARPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQM 682
+ ++++G + + + LI P ++G+ VP+T+R +D+E +GQ Y FV SR +M
Sbjct: 349 RRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFV-SRGEM 407
Query: 683 EKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIF 742
E D++ +++E G++ NLYGT I S+R V GK C+LDV+ A+K L+ A+ P +F
Sbjct: 408 EADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVF 467
Query: 743 IKPKSIEALMEMNR----------RQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEE 792
I+ E L MNR + T + +++ ++++ +G YF + +LE
Sbjct: 468 IEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLER 527
Query: 793 IYNKIKQIIEDQSGHYIWVP 812
+ +++ +E WVP
Sbjct: 528 TFRELQTAMEKLRTEPQWVP 547
Score = 31.6 bits (70), Expect = 3.1
Identities = 26/94 (27%), Positives = 42/94 (44%), Gaps = 16/94 (17%)
Query: 220 PPETIMEVNLLKGPK---GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGD 276
PP+ + V + K G+ F + GG + I +I+ GG + G L +GD
Sbjct: 134 PPDAVRMVGIRKTAGEHLGVTFRVEGG----------ELVIARILHGGMVAQQGLLHVGD 183
Query: 277 RLLAVNNTNL-QDVRHEEAVASLKNTSDMVYLKV 309
+ VN + D R + + L+N S V LK+
Sbjct: 184 IIKEVNGQPVGSDPRALQEL--LRNASGSVILKI 215
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 168 bits (426), Expect = 2e-41
Identities = 113/410 (27%), Positives = 202/410 (49%), Gaps = 34/410 (8%)
Query: 411 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVT--IVAQYRPE 468
V+ I+ GG G L GD I +NG+++ N T EQ L+ S+T IV YR +
Sbjct: 509 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 568
Query: 469 EYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLS 526
S E + +++ G R +YVRA F+YD +D +P + G+
Sbjct: 569 SSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDLIPCKEAGIR 610
Query: 527 FSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERA-RLKTVKFHARTG 585
F GDI+ +I+ D WWQ +L + ++ G+IPS + E + ++ K +
Sbjct: 611 FRVGDIIQIISKDDHNWWQGKL--ENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQAS 668
Query: 586 MIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPM---KDRVND 642
+ D Y N + +++YE V + + +++LG + + +
Sbjct: 669 CTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKN 728
Query: 643 DLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLY 702
LI++ P +F +PHTTRP + +E +G++Y+FV S +QM +DI +N+++E G D +Y
Sbjct: 729 TLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGSHEDAMY 787
Query: 703 GTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQ 762
GT ++++R + E+G ILDV A+K L+ A+ P +FI +I +N ++ ++
Sbjct: 788 GTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITP--GLNEDESLQR 845
Query: 763 ANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVP 812
K D L++ + YF + + ++E +++ +E WVP
Sbjct: 846 LQKESD---ILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 892
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 168 bits (426), Expect = 2e-41
Identities = 114/409 (27%), Positives = 203/409 (49%), Gaps = 37/409 (9%)
Query: 411 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVT--IVAQYRPE 468
V+ I+ GG G L GD I +NG+++ N T EQ L+ S+T IV YR +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574
Query: 469 EYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLS 526
S E + +++ G R +YVRA F+YD +D +P + G+
Sbjct: 575 SSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDLIPCKEAGIR 616
Query: 527 FSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGM 586
F GDI+ +I+ D WWQ +L + ++ G+IPS + E R+ +
Sbjct: 617 FRVGDIIQIISKDDHNWWQGKL--ENSKNGTAGLIPSPELQEW----RVACIAMEKTKQE 670
Query: 587 IESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPM---KDRVNDD 643
+++ + G Y K L +++YE V + + +++LG + + +
Sbjct: 671 QQASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNT 730
Query: 644 LISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYG 703
LI++ P +F +PHTTRP + +E +G++Y+FV S +QM +DI +N+++E G D +YG
Sbjct: 731 LITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGSHEDAMYG 789
Query: 704 TSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQA 763
T ++++R + E+G ILDV A+K L+ A+ P +FI +I +N ++ ++
Sbjct: 790 TKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITP--GLNEDESLQRL 847
Query: 764 NKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVP 812
K D L++ + YF + + ++E +++ +E WVP
Sbjct: 848 QKESD---ILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 893
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 162 bits (410), Expect = 1e-39
Identities = 106/407 (26%), Positives = 191/407 (46%), Gaps = 46/407 (11%)
Query: 411 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEY 470
V+ IL GG G L GD IL +NG N+ N + +Q A+K +++ + P +
Sbjct: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
Query: 471 SRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFS 528
SR + +++RA FDYD +D+ +P + GL F+
Sbjct: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
Query: 529 YGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIE 588
GDI+ +IN D WWQ R+ E G+IPS + E + + ++ A +
Sbjct: 188 TGDIIQIINKDDSNWWQGRV--EGSSKESAGLIPSPELQEWRVASMAQSAPSEAPSCSPF 245
Query: 589 SNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPM---KDRVNDDLI 645
+ D Y + + ++SYE V R + ++++G + + + L+
Sbjct: 246 GKK--KKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALL 303
Query: 646 SEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTS 705
S+ P KF VP+TTRP R +E DG++YHF +S E+M ++I N+F+E G + N++GT
Sbjct: 304 SQNPEKFVYPVPYTTRPPRKSEEDGKEYHF-ISTEEMTRNISANEFLEFGSYQGNMFGTK 362
Query: 706 IQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANK 765
++V + ++ K ILD+ +K ++ A+L P +FI P ++ E +
Sbjct: 363 FETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP--------TDQGTQTEALQQ 414
Query: 766 IYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVP 812
+ + + ++ YF + + ++E K+++ + WVP
Sbjct: 415 LQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
Score = 42.4 bits (98), Expect = 0.002
Identities = 18/56 (32%), Positives = 32/56 (57%)
Query: 254 SIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
S + +I+ GG + G L +GD +L +N TN+ + ++ ++K T M+ LKV
Sbjct: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
Score = 30.8 bits (68), Expect = 5.3
Identities = 30/121 (24%), Positives = 49/121 (40%), Gaps = 12/121 (9%)
Query: 162 ITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVV----RRR 217
+ +I+ GG G L V D +L +N +V+ + +A+KE ++ L V + R
Sbjct: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
Query: 218 QPPPETIMEVNLLKGP--------KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKD 269
P + M P K G A G Q I D+S + +EG + +
Sbjct: 156 LPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
Query: 270 G 270
G
Sbjct: 216 G 216
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 148 bits (373), Expect = 2e-35
Identities = 128/390 (32%), Positives = 187/390 (47%), Gaps = 73/390 (18%)
Query: 130 EEIVLE--RGNSGLGFSIAGGIDN-PHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
EE+ L R GLG SIAGG + P+ DD GIFI+++ G AA G + V D +L V
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 187 NEVDVSEVVHSRAVEALKEAGPVVRLVV-RRRQPPPETIMEVNLLK-------------- 231
N V + H AVEAL+ AG V++ V R R PE + + L+
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843
Query: 232 -----------GP-------------KGLGFSIAGGIGNQ-HIPGDNSIYITKIIEGGAA 266
GP +GLGFSIAGG G+ + GD I++++I EGGAA
Sbjct: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903
Query: 267 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDY 326
+ G LQ+GDR+L++N ++ + RH+ AV+ L S + L + + L P
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSS 963
Query: 327 ASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRK 386
T A+A I+ + P P +P S P + A + +
Sbjct: 964 PPT-AAVATTSIT--------------TATPGVPGLP----SLAPSLLAAALEGPYPVEE 1004
Query: 387 IILHKGSTGLGFNIVGGEDGE---------GIFVSFILAGGPADLSGELRRGDRILSVNG 437
I L + LG +IVGG D G+F+S +L G A SG LR GDRIL+VNG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 438 VNLRNATHEQAAAALKRAGQSVTIVAQYRP 467
++R+ATH++A +AL R ++++ + P
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
Score = 128 bits (322), Expect = 2e-29
Identities = 104/301 (34%), Positives = 144/301 (47%), Gaps = 40/301 (13%)
Query: 83 GPVPPKPVPGKS--------------TPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFK 128
GP+PP P+P S TP + G PS P +G +
Sbjct: 952 GPLPPSPLPHSSPPTAAVATTSITTATPGVPGL-PSLAPSLLAA---------ALEGPYP 1001
Query: 129 YEEIVLERGNSGLGFSIAGGIDNPHVP---DDPGIFITKIIPGGAAAMDGRLGVNDCVLR 185
EEI L R LG SI GG D+ P +PG+FI+K++P G AA G L V D +L
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
Query: 186 VNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGP-KGLGFSIAGGI 244
VN DV + H AV AL + L+VRR P P + E+ + K P + LG SI GG
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRR-DPAPPGLRELCIQKAPGERLGISIRGGA 1119
Query: 245 ----GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKN 300
GN P D I+I+K+ GAA +DGRL++G RLL VN +L + H EAV L++
Sbjct: 1120 RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
Query: 301 TSDMVYLKVAK--PGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPA 358
D + + V S +P A+ F A I H +SL + +++ ++S
Sbjct: 1180 VGDTLTVLVCDGFEASTDAALEVSPGVIANPFAA----GIGHRNSLESISSIDRELSPEG 1235
Query: 359 P 359
P
Sbjct: 1236 P 1236
Score = 105 bits (262), Expect = 2e-22
Identities = 79/253 (31%), Positives = 122/253 (48%), Gaps = 39/253 (15%)
Query: 222 ETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNS-IYITKIIEGGAAQKDGRLQIGDRLLA 280
E + + +L+ GLG SIAGG G+ GD+ I+I+++ E G A + G +++GD+LL
Sbjct: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLE 782
Query: 281 VNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTAL--ADNHI 338
VN LQ H EAV +L+ V ++V + + P+ A T T L D++
Sbjct: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWR-------ERMVEPENAVTITPLRPEDDYS 835
Query: 339 SHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGF 398
G L P +PP P+ R+ L + GLGF
Sbjct: 836 PRERRGGGLRL----------PLLPPESPGPL-----------RQRHVACLARSERGLGF 874
Query: 399 NIVGGEDG-------EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAA 451
+I GG+ GIFVS I GG A +G L+ GDR+LS+NGV++ A H+ A +
Sbjct: 875 SIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSL 934
Query: 452 LKRAGQSVTIVAQ 464
L A ++ ++ +
Sbjct: 935 LTAASPTIALLLE 947
Score = 87.4 bits (215), Expect = 5e-17
Identities = 92/338 (27%), Positives = 135/338 (39%), Gaps = 24/338 (7%)
Query: 134 LERGNSGLGFSIAGGIDN-PHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVS 192
L R GLGFSIAGG + P+ D GIF+++I GGAA G L V D VL +N VDV+
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 193 EVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGD 252
E H AV L A P + L++ R P + P + + +PG
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
Query: 253 NSI---YITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
S+ + +EG ++ RL L ++ D H ++ V++
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSD--HSSHPFGVQEPG--VFISK 1040
Query: 310 AKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSY-----PAPPQVPP 364
P L D +H ++ L ++S PAPP +
Sbjct: 1041 VLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE 1100
Query: 365 TRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSG 424
P L I + G+ G N D EGIF+S + G A G
Sbjct: 1101 LCIQKAPGERLG----------ISIRGGARGHAGNPRDPTD-EGIFISKVSPTGAAGRDG 1149
Query: 425 ELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
LR G R+L VN +L TH +A L+ G ++T++
Sbjct: 1150 RLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 13/92 (14%)
Query: 375 LAEEDFTREPRKIILHKGSTGLGFNIVGGE-------DGEGIFVSFILAGGPADLSGELR 427
+ EE+ T + + + + GLG +I GG+ D EGIF+S + GPA +G +R
Sbjct: 722 IEEEELT-----LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VR 775
Query: 428 RGDRILSVNGVNLRNATHEQAAAALKRAGQSV 459
GD++L VNGV L+ A H +A AL+ AG +V
Sbjct: 776 VGDKLLEVNGVALQGAEHHEAVEALRGAGTAV 807
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 148 bits (373), Expect = 2e-35
Identities = 128/390 (32%), Positives = 187/390 (47%), Gaps = 73/390 (18%)
Query: 130 EEIVLE--RGNSGLGFSIAGGIDN-PHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
EE+ L R GLG SIAGG + P+ DD GIFI+++ G AA G + V D +L V
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 187 NEVDVSEVVHSRAVEALKEAGPVVRLVV-RRRQPPPETIMEVNLLK-------------- 231
N V + H AVEAL+ AG V++ V R R PE + + L+
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843
Query: 232 -----------GP-------------KGLGFSIAGGIGNQ-HIPGDNSIYITKIIEGGAA 266
GP +GLGFSIAGG G+ + GD I++++I EGGAA
Sbjct: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903
Query: 267 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDY 326
+ G LQ+GDR+L++N ++ + RH+ AV+ L S + L + + L P
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSS 963
Query: 327 ASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRK 386
T A+A I+ + P P +P S P + A + +
Sbjct: 964 PPT-AAVATTSIT--------------TATPGVPGLP----SLAPSLLAAALEGPYPVEE 1004
Query: 387 IILHKGSTGLGFNIVGGEDGE---------GIFVSFILAGGPADLSGELRRGDRILSVNG 437
I L + LG +IVGG D G+F+S +L G A SG LR GDRIL+VNG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 438 VNLRNATHEQAAAALKRAGQSVTIVAQYRP 467
++R+ATH++A +AL R ++++ + P
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
Score = 128 bits (322), Expect = 2e-29
Identities = 104/301 (34%), Positives = 144/301 (47%), Gaps = 40/301 (13%)
Query: 83 GPVPPKPVPGKS--------------TPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFK 128
GP+PP P+P S TP + G PS P +G +
Sbjct: 952 GPLPPSPLPHSSPPTAAVATTSITTATPGVPGL-PSLAPSLLAA---------ALEGPYP 1001
Query: 129 YEEIVLERGNSGLGFSIAGGIDNPHVP---DDPGIFITKIIPGGAAAMDGRLGVNDCVLR 185
EEI L R LG SI GG D+ P +PG+FI+K++P G AA G L V D +L
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
Query: 186 VNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGP-KGLGFSIAGGI 244
VN DV + H AV AL + L+VRR P P + E+ + K P + LG SI GG
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRR-DPAPPGLRELCIQKAPGERLGISIRGGA 1119
Query: 245 ----GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKN 300
GN P D I+I+K+ GAA +DGRL++G RLL VN +L + H EAV L++
Sbjct: 1120 RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
Query: 301 TSDMVYLKVAK--PGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPA 358
D + + V S +P A+ F A I H +SL + +++ ++S
Sbjct: 1180 VGDTLTVLVCDGFEASTDAALEVSPGVIANPFAA----GIGHRNSLESISSIDRELSPEG 1235
Query: 359 P 359
P
Sbjct: 1236 P 1236
Score = 105 bits (262), Expect = 2e-22
Identities = 79/253 (31%), Positives = 122/253 (48%), Gaps = 39/253 (15%)
Query: 222 ETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNS-IYITKIIEGGAAQKDGRLQIGDRLLA 280
E + + +L+ GLG SIAGG G+ GD+ I+I+++ E G A + G +++GD+LL
Sbjct: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLE 782
Query: 281 VNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTAL--ADNHI 338
VN LQ H EAV +L+ V ++V + + P+ A T T L D++
Sbjct: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWR-------ERMVEPENAVTITPLRPEDDYS 835
Query: 339 SHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGF 398
G L P +PP P+ R+ L + GLGF
Sbjct: 836 PRERRGGGLRL----------PLLPPESPGPL-----------RQRHVACLARSERGLGF 874
Query: 399 NIVGGEDG-------EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAA 451
+I GG+ GIFVS I GG A +G L+ GDR+LS+NGV++ A H+ A +
Sbjct: 875 SIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSL 934
Query: 452 LKRAGQSVTIVAQ 464
L A ++ ++ +
Sbjct: 935 LTAASPTIALLLE 947
Score = 87.4 bits (215), Expect = 5e-17
Identities = 92/338 (27%), Positives = 135/338 (39%), Gaps = 24/338 (7%)
Query: 134 LERGNSGLGFSIAGGIDN-PHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVS 192
L R GLGFSIAGG + P+ D GIF+++I GGAA G L V D VL +N VDV+
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 193 EVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGD 252
E H AV L A P + L++ R P + P + + +PG
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
Query: 253 NSI---YITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
S+ + +EG ++ RL L ++ D H ++ V++
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSD--HSSHPFGVQEPG--VFISK 1040
Query: 310 AKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSY-----PAPPQVPP 364
P L D +H ++ L ++S PAPP +
Sbjct: 1041 VLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE 1100
Query: 365 TRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSG 424
P L I + G+ G N D EGIF+S + G A G
Sbjct: 1101 LCIQKAPGERLG----------ISIRGGARGHAGNPRDPTD-EGIFISKVSPTGAAGRDG 1149
Query: 425 ELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
LR G R+L VN +L TH +A L+ G ++T++
Sbjct: 1150 RLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 13/92 (14%)
Query: 375 LAEEDFTREPRKIILHKGSTGLGFNIVGGE-------DGEGIFVSFILAGGPADLSGELR 427
+ EE+ T + + + + GLG +I GG+ D EGIF+S + GPA +G +R
Sbjct: 722 IEEEELT-----LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VR 775
Query: 428 RGDRILSVNGVNLRNATHEQAAAALKRAGQSV 459
GD++L VNGV L+ A H +A AL+ AG +V
Sbjct: 776 VGDKLLEVNGVALQGAEHHEAVEALRGAGTAV 807
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 140 bits (353), Expect = 5e-33
Identities = 160/676 (23%), Positives = 271/676 (40%), Gaps = 105/676 (15%)
Query: 160 IFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQP 219
IF+ +I AA DG + D VL++N + + A ++ + +++VV+R +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDE- 264
Query: 220 PPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLL 279
LL P L SI ++ D+ I + + + R R
Sbjct: 265 ------RATLLNVPD-LSDSIHSANASER---DDISEIQSLASDHSGRSHDRPPRRSRSR 314
Query: 280 AVNNTN--LQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALA-DN 336
+ + + RH S + +++KPG++ +A T + +
Sbjct: 315 SPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVER 374
Query: 337 HISHNSSLGYLGAVESKVSYPAP--PQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGST 394
+ SL V ++V P P P P H E+ R K++ +
Sbjct: 375 NEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTH---EDGILRPSMKLVKFRKGD 431
Query: 395 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKR 454
+G + GG D GIFV+ +L PA G L GD+IL VN V+ N E+A L
Sbjct: 432 SVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLD 489
Query: 455 A--GQSVTIVAQYRPEEYSRF-ESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFD 511
G+ VTI+AQ + + Y R ES + D S Y+R F+
Sbjct: 490 LPKGEEVTILAQKKKDVYRRIVESDVGD-----------------------SFYIRTHFE 526
Query: 512 YDRTRDSCLPSQGLSFSYGDILHVI----NASDDEWWQARLVTPHGESEQIGVIPSKKRV 567
Y++ GLSF+ G++ V+ N W R+ H E E+ G+IP+K R
Sbjct: 527 YEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVER-GIIPNKNRA 580
Query: 568 EKKERARLKTVK--------FHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPV 619
E+ + K F G+ S R+ +D + + + +YE V
Sbjct: 581 EQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDL----SAQPVQTKFPAYERV 636
Query: 620 TRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSR 679
+E + RPV I GP+ D + L E P D + +
Sbjct: 637 VLREAGFLRPVTIFGPIADVAREKLAREEP----------------------DIYQIAKS 674
Query: 680 EQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPI 739
E +AG + + +++ + ++ KH +LDV+ NA+ RL AQ YPI
Sbjct: 675 EPR----------DAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPI 724
Query: 740 AIFIKPKSIEALMEMNRR---QTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEE-IYN 795
+F+ P S + + M R ++ + A K+Y+++ KL + FT + +S+ + Y
Sbjct: 725 VVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYG 784
Query: 796 KIKQIIEDQSGHYIWV 811
+K+ I+ Q +WV
Sbjct: 785 ALKEAIQQQQNQLVWV 800
Score = 63.9 bits (154), Expect = 6e-10
Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 9/234 (3%)
Query: 235 GLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEE 293
G G +I+GG N H G+ SI I+ +++GG A+ G+LQ DR+ VN ++ +V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
Query: 294 AVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK 353
AV L+ + + + + + + P+ S + + H+ G G V +
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
Query: 354 VSYPAPPQVPPTR---YSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIF 410
P +R SP +P K+ L K + + IF
Sbjct: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGL---RLASHIF 207
Query: 411 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQ 464
V I A G ++ GD +L +NG N + A ++R+ + +V Q
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
Score = 57.0 bits (136), Expect = 7e-08
Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 11/96 (11%)
Query: 140 GLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSR 198
G G +I+GG DNPH + I I+ ++ GG A +G+L ND V VN V + V H+
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
Query: 199 AVEALKEAGPVVRLVVRRR--------QPPPETIME 226
AV+ L+++G ++ +RR+ +P PE + +
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSD 126
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 26/129 (20%)
Query: 377 EEDFTREPRKIILHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELRR 428
EE E + LH+ G G I GG D GE I +S +L GGPA+ G+L+
Sbjct: 14 EETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQE 71
Query: 429 GDRILSVNGVNLRNATHEQAAAALKRAGQSVTI-----------VAQYRPE-----EYSR 472
DR+ VNGV++ N H A L+++G++ I V++ PE E
Sbjct: 72 NDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDS 131
Query: 473 FESKIHDLR 481
++ +IHD R
Sbjct: 132 YDEEIHDPR 140
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 140 bits (353), Expect = 5e-33
Identities = 160/676 (23%), Positives = 271/676 (40%), Gaps = 105/676 (15%)
Query: 160 IFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQP 219
IF+ +I AA DG + D VL++N + + A ++ + +++VV+R +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDE- 264
Query: 220 PPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLL 279
LL P L SI ++ D+ I + + + R R
Sbjct: 265 ------RATLLNVPD-LSDSIHSANASER---DDISEIQSLASDHSGRSHDRPPRRSRSR 314
Query: 280 AVNNTN--LQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALA-DN 336
+ + + RH S + +++KPG++ +A T + +
Sbjct: 315 SPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVER 374
Query: 337 HISHNSSLGYLGAVESKVSYPAP--PQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGST 394
+ SL V ++V P P P P H E+ R K++ +
Sbjct: 375 NEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTH---EDGILRPSMKLVKFRKGD 431
Query: 395 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKR 454
+G + GG D GIFV+ +L PA G L GD+IL VN V+ N E+A L
Sbjct: 432 SVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLD 489
Query: 455 A--GQSVTIVAQYRPEEYSRF-ESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFD 511
G+ VTI+AQ + + Y R ES + D S Y+R F+
Sbjct: 490 LPKGEEVTILAQKKKDVYRRIVESDVGD-----------------------SFYIRTHFE 526
Query: 512 YDRTRDSCLPSQGLSFSYGDILHVI----NASDDEWWQARLVTPHGESEQIGVIPSKKRV 567
Y++ GLSF+ G++ V+ N W R+ H E E+ G+IP+K R
Sbjct: 527 YEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVER-GIIPNKNRA 580
Query: 568 EKKERARLKTVK--------FHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPV 619
E+ + K F G+ S R+ +D + + + +YE V
Sbjct: 581 EQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDL----SAQPVQTKFPAYERV 636
Query: 620 TRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSR 679
+E + RPV I GP+ D + L E P D + +
Sbjct: 637 VLREAGFLRPVTIFGPIADVAREKLAREEP----------------------DIYQIAKS 674
Query: 680 EQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPI 739
E +AG + + +++ + ++ KH +LDV+ NA+ RL AQ YPI
Sbjct: 675 EPR----------DAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPI 724
Query: 740 AIFIKPKSIEALMEMNRR---QTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEE-IYN 795
+F+ P S + + M R ++ + A K+Y+++ KL + FT + +S+ + Y
Sbjct: 725 VVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYG 784
Query: 796 KIKQIIEDQSGHYIWV 811
+K+ I+ Q +WV
Sbjct: 785 ALKEAIQQQQNQLVWV 800
Score = 63.9 bits (154), Expect = 6e-10
Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 9/234 (3%)
Query: 235 GLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEE 293
G G +I+GG N H G+ SI I+ +++GG A+ G+LQ DR+ VN ++ +V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
Query: 294 AVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK 353
AV L+ + + + + + + P+ S + + H+ G G V +
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
Query: 354 VSYPAPPQVPPTR---YSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIF 410
P +R SP +P K+ L K + + IF
Sbjct: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGL---RLASHIF 207
Query: 411 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQ 464
V I A G ++ GD +L +NG N + A ++R+ + +V Q
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
Score = 57.0 bits (136), Expect = 7e-08
Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 11/96 (11%)
Query: 140 GLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSR 198
G G +I+GG DNPH + I I+ ++ GG A +G+L ND V VN V + V H+
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
Query: 199 AVEALKEAGPVVRLVVRRR--------QPPPETIME 226
AV+ L+++G ++ +RR+ +P PE + +
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSD 126
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 26/129 (20%)
Query: 377 EEDFTREPRKIILHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELRR 428
EE E + LH+ G G I GG D GE I +S +L GGPA+ G+L+
Sbjct: 14 EETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQE 71
Query: 429 GDRILSVNGVNLRNATHEQAAAALKRAGQSVTI-----------VAQYRPE-----EYSR 472
DR+ VNGV++ N H A L+++G++ I V++ PE E
Sbjct: 72 NDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDS 131
Query: 473 FESKIHDLR 481
++ +IHD R
Sbjct: 132 YDEEIHDPR 140
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 133 bits (334), Expect = 8e-31
Identities = 160/640 (25%), Positives = 255/640 (39%), Gaps = 150/640 (23%)
Query: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVN-----NTNLQDVRH----EEAVASLKNTSD 303
+ I+I I + G A + LQ GD +L +N N +L D R E SL D
Sbjct: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
Query: 304 MVYLKVAKP-------------GSLHLNDMYAPP----DYASTFTALADNHIS----HNS 342
V P G ++M +PP D AS + +HI H
Sbjct: 291 RGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQ 350
Query: 343 SLGYLGAVESKVSYPAPPQV----------PPTRYSPIPRHM------------LAEEDF 380
+S V P + P + S +PR + + +
Sbjct: 351 RSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGY 410
Query: 381 TREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
+ + R + KG + +G + GG D GIFVS + AG PAD G ++ GD+IL VN V
Sbjct: 411 SPDTRVVRFLKGKS-IGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
Query: 441 RNATHEQAAAALKRA--GQSVTIVAQYRPEEYSRF-ESKIHDLREQMMNSSMSSGSGSLR 497
+N T E+A L G+ + +V Q + + + + +S++ D
Sbjct: 468 QNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGD------------------ 509
Query: 498 TSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN----------ASDDEWWQAR 547
S Y+R F+ + + P GL F+ GD+ HV++ A W R
Sbjct: 510 -----SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVR 559
Query: 548 LVTPHGESEQIGVIPSKKRVEKK---ERARLKTVKFHARTGMIESNRDFPGLSDDYYGAK 604
+ E E+ G+IP++ R E+ E A+ + + +F L GAK
Sbjct: 560 MGRDLREQER-GIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAK 618
Query: 605 NLKGQEDAILS----------YEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGS 654
+ LS YE V +E + RPV+ILGP+ D L +E P +F
Sbjct: 619 KTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQF-- 676
Query: 655 CVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE 714
E+ E + + +K I+ + +VR +AE
Sbjct: 677 ------------EI----------AETVSRTDSPSKIIK------------LDTVRVIAE 702
Query: 715 RGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKS---IEALMEMNRRQTYEQANKIYDKAM 771
+ KH +LDV+ +AI+RL Q YPI +F P+S ++AL + + ++Y +A
Sbjct: 703 KDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQ 762
Query: 772 KLEQEFGEYFTAIVQGDSLEEI-YNKIKQIIEDQSGHYIW 810
KL + FTA + + + Y ++K II +Q IW
Sbjct: 763 KLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
Score = 55.8 bits (133), Expect = 2e-07
Identities = 65/263 (24%), Positives = 110/263 (41%), Gaps = 38/263 (14%)
Query: 229 LLKGPK-GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQ 287
L K P+ G G +I+GG + PG S+ ++ ++ GG A+ GRLQ GD ++ VN +++
Sbjct: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSME 86
Query: 288 DVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISH----NSS 343
+ A+ LK + M + V +P +HL A P + D+ +
Sbjct: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQG 146
Query: 344 LGYLG--AVESKVSYPAPPQVP-PTRYSPIPRH---------------------MLAEED 379
GY G + S S+ + P P R H L +D
Sbjct: 147 RGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQD 206
Query: 380 FTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
+P K +L K F G + G IF+ I G A L+ GD IL +NGV+
Sbjct: 207 VQMKPVKSVLVKRRDSEEF---GVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVS 263
Query: 440 LRNATHEQAAAALKRAGQSVTIV 462
+N + ++++ ++++
Sbjct: 264 SQNLSLNDTRRLIEKSEGKLSLL 286
Score = 47.8 bits (112), Expect = 4e-05
Identities = 29/72 (40%), Positives = 39/72 (54%), Gaps = 4/72 (5%)
Query: 395 GLGFNIVGGED--GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 452
G G I GG D G + VS ++ GGPA+ G L+ GD I+ VNGV++ NAT A L
Sbjct: 40 GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQIL 97
Query: 453 KRAGQSVTIVAQ 464
K + I +
Sbjct: 98 KTCTKMANITVK 109
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 129 bits (323), Expect = 1e-29
Identities = 122/519 (23%), Positives = 217/519 (41%), Gaps = 105/519 (20%)
Query: 369 PIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRR 428
P+P ++ E+ R + L K LG I E I V+ I+ GG A+ SG L
Sbjct: 140 PLPDNIPESEEAMRI---VCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYA 196
Query: 429 GDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSS 488
GD+++ VNGV++ EQ L + ++ K+ + + +NS
Sbjct: 197 GDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMF--------------KVVPVSDPPVNS- 241
Query: 489 MSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFSYGDIL------------- 533
++ +YVRA+ +Y D +P GL F GDIL
Sbjct: 242 ------------QQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQA 289
Query: 534 ----------------HVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKK--ERARL 575
H++ E+W ++ PH + I ++ + K E+
Sbjct: 290 RKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVE 349
Query: 576 KTVKFHARTGMIESNRDFPGLSDDYYGAKNLKG----QEDAILS---------------- 615
+ + E +F G ++ A + + + LS
Sbjct: 350 ADEETFESEELSEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAV 409
Query: 616 ---YEPVTRQEIHYA---RPVIILGPMKDRVND---DLISEFPHKFGSCVPHTTRPRRDN 666
YE V R + + R ++++GP VN+ LI P F S VPHTTR ++
Sbjct: 410 GAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSY 469
Query: 667 EVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGN 726
E++G++YH+V S+E E I ++ +E G++ +LYGTS+ +V+ V GK C++D+
Sbjct: 470 EMNGREYHYV-SKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQ 528
Query: 727 AIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTY------------EQANKIYDKAMKLE 774
I+ ++ +L P IFIKP ++ + + + E ++ + A ++E
Sbjct: 529 DIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRME 588
Query: 775 QEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 813
+FG++F ++ DSL + ++ I+ WVP+
Sbjct: 589 TQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 222 ETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAV 281
E + V L+K + LG +I + GD I + +II GG A++ G L GD+L+ V
Sbjct: 150 EAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDKLVEV 203
Query: 282 NNTNLQDVRHEEAVASLKNTSDMVYLKV 309
N +++ + E+ + L + + KV
Sbjct: 204 NGVSVEGLDPEQVIHILAMSRGTIMFKV 231
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 128 bits (322), Expect = 2e-29
Identities = 157/629 (24%), Positives = 250/629 (39%), Gaps = 138/629 (21%)
Query: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKP 312
+ I++ ++ G A KDG L GD +L +N T +++ +A ++ + + L V +
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 313 GSL------HLND------------------------MYAPPDYASTFTALADNHISHN- 341
LND Y+ DY S+ L + S
Sbjct: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
Query: 342 --SSLGYLGAVESKVSYP---APPQVPPT----RYS---PIPRHMLAEEDFTREP----- 384
S L +GA + A VP T RY P P+ A F R
Sbjct: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEA 504
Query: 385 -----RKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
K++ K +G + GG D GIFV+ I G A+ G L+ GD+IL VN +
Sbjct: 505 IYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQD 562
Query: 440 LRNATHEQAAAALKRA--GQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR 497
R E A L G+ VTI+AQ R + Y ++ G G
Sbjct: 563 FRGLVREDAVLYLLEIPKGEMVTILAQSRADVY---------------RDILACGRGD-- 605
Query: 498 TSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQ 557
S ++R+ F+ ++ Q L+F+ G++ V++ D L G +
Sbjct: 606 -----SFFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELE 655
Query: 558 IGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAK-NL-KGQED--AI 613
G+IP+K R E+ + +A+ DF + G K NL K +ED A+
Sbjct: 656 KGLIPNKSRAEQMASVQ------NAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAV 709
Query: 614 LS-------YEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDN 666
+S YE V +E + RPV++ GP+ D + L +E P F + T P
Sbjct: 710 VSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---- 762
Query: 667 EVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGN 726
KD K + N +VR + E+ KH +LDV+
Sbjct: 763 -----------------KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPK 796
Query: 727 AIKRLQQAQLYPIAIFIKPKSIEALMEMNRR---QTYEQANKIYDKAMKLEQEFGEYFTA 783
A+ L Q +PI IF P S + + M +R + + + K++D+A KL++ FTA
Sbjct: 797 AVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTA 856
Query: 784 IVQGDSLEEI-YNKIKQIIEDQSGHYIWV 811
+ +S + + +K I+ Q G +WV
Sbjct: 857 TINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 63.2 bits (152), Expect = 1e-09
Identities = 34/90 (37%), Positives = 55/90 (61%), Gaps = 3/90 (3%)
Query: 128 KYEEIVLERGNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
+Y + + G G +++GG DNPH + + I I+ ++PGG A DG L ND V+ V
Sbjct: 31 QYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMV 88
Query: 187 NEVDVSEVVHSRAVEALKEAGPVVRLVVRR 216
N + +V+HS AV+ L+++G V +VV+R
Sbjct: 89 NGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
Score = 58.9 bits (141), Expect = 2e-08
Identities = 32/92 (34%), Positives = 52/92 (56%), Gaps = 3/92 (3%)
Query: 234 KGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHE 292
+G G +++GG N H G+ SI I+ ++ GG A DG LQ DR++ VN T ++DV H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 293 EAVASLKNTSDMVYLKVAKPGSLHLNDMYAPP 324
AV L+ + + + V +P + + + A P
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASP 131
Score = 48.5 bits (114), Expect = 2e-05
Identities = 35/100 (35%), Positives = 51/100 (51%), Gaps = 11/100 (11%)
Query: 378 EDFTREPRKIILHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELRRG 429
E+ E + L K S G G + GG D GE I +S +L GGPAD G L+
Sbjct: 25 EELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQEN 82
Query: 430 DRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEE 469
DR++ VNG + + H A L+++G+ IV + RP +
Sbjct: 83 DRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK-RPRK 121
Score = 36.6 bits (83), Expect = 0.097
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 12/87 (13%)
Query: 216 RRQPPPETIMEVN--LLKGPKG--LGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGR 271
R P E I N +++ KG +G +AGG D I++ I EG +A+++G
Sbjct: 497 RPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG- 548
Query: 272 LQIGDRLLAVNNTNLQDVRHEEAVASL 298
LQ GD++L VN + + + E+AV L
Sbjct: 549 LQEGDQILKVNTQDFRGLVREDAVLYL 575
Score = 32.3 bits (72), Expect = 1.8
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 4/108 (3%)
Query: 406 GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQY 465
G IFV + G A G L GD IL +NG N + A ++++ + +V
Sbjct: 324 GSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
Query: 466 RPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYD 513
++ ++D ++ + S + S E+R Y DYD
Sbjct: 384 DSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQY----SDYD 427
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 128 bits (322), Expect = 2e-29
Identities = 157/629 (24%), Positives = 250/629 (39%), Gaps = 138/629 (21%)
Query: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKP 312
+ I++ ++ G A KDG L GD +L +N T +++ +A ++ + + L V +
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 313 GSL------HLND------------------------MYAPPDYASTFTALADNHISHN- 341
LND Y+ DY S+ L + S
Sbjct: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
Query: 342 --SSLGYLGAVESKVSYP---APPQVPPT----RYS---PIPRHMLAEEDFTREP----- 384
S L +GA + A VP T RY P P+ A F R
Sbjct: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEA 504
Query: 385 -----RKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
K++ K +G + GG D GIFV+ I G A+ G L+ GD+IL VN +
Sbjct: 505 IYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQD 562
Query: 440 LRNATHEQAAAALKRA--GQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLR 497
R E A L G+ VTI+AQ R + Y ++ G G
Sbjct: 563 FRGLVREDAVLYLLEIPKGEMVTILAQSRADVY---------------RDILACGRGD-- 605
Query: 498 TSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQ 557
S ++R+ F+ ++ Q L+F+ G++ V++ D L G +
Sbjct: 606 -----SFFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELE 655
Query: 558 IGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAK-NL-KGQED--AI 613
G+IP+K R E+ + +A+ DF + G K NL K +ED A+
Sbjct: 656 KGLIPNKSRAEQMASVQ------NAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAV 709
Query: 614 LS-------YEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDN 666
+S YE V +E + RPV++ GP+ D + L +E P F + T P
Sbjct: 710 VSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---- 762
Query: 667 EVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGN 726
KD K + N +VR + E+ KH +LDV+
Sbjct: 763 -----------------KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPK 796
Query: 727 AIKRLQQAQLYPIAIFIKPKSIEALMEMNRR---QTYEQANKIYDKAMKLEQEFGEYFTA 783
A+ L Q +PI IF P S + + M +R + + + K++D+A KL++ FTA
Sbjct: 797 AVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTA 856
Query: 784 IVQGDSLEEI-YNKIKQIIEDQSGHYIWV 811
+ +S + + +K I+ Q G +WV
Sbjct: 857 TINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 63.2 bits (152), Expect = 1e-09
Identities = 34/90 (37%), Positives = 55/90 (61%), Gaps = 3/90 (3%)
Query: 128 KYEEIVLERGNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
+Y + + G G +++GG DNPH + + I I+ ++PGG A DG L ND V+ V
Sbjct: 31 QYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMV 88
Query: 187 NEVDVSEVVHSRAVEALKEAGPVVRLVVRR 216
N + +V+HS AV+ L+++G V +VV+R
Sbjct: 89 NGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
Score = 58.9 bits (141), Expect = 2e-08
Identities = 32/92 (34%), Positives = 52/92 (56%), Gaps = 3/92 (3%)
Query: 234 KGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHE 292
+G G +++GG N H G+ SI I+ ++ GG A DG LQ DR++ VN T ++DV H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 293 EAVASLKNTSDMVYLKVAKPGSLHLNDMYAPP 324
AV L+ + + + V +P + + + A P
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASP 131
Score = 48.5 bits (114), Expect = 2e-05
Identities = 35/100 (35%), Positives = 51/100 (51%), Gaps = 11/100 (11%)
Query: 378 EDFTREPRKIILHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELRRG 429
E+ E + L K S G G + GG D GE I +S +L GGPAD G L+
Sbjct: 25 EELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQEN 82
Query: 430 DRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEE 469
DR++ VNG + + H A L+++G+ IV + RP +
Sbjct: 83 DRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK-RPRK 121
Score = 36.6 bits (83), Expect = 0.097
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 12/87 (13%)
Query: 216 RRQPPPETIMEVN--LLKGPKG--LGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGR 271
R P E I N +++ KG +G +AGG D I++ I EG +A+++G
Sbjct: 497 RPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG- 548
Query: 272 LQIGDRLLAVNNTNLQDVRHEEAVASL 298
LQ GD++L VN + + + E+AV L
Sbjct: 549 LQEGDQILKVNTQDFRGLVREDAVLYL 575
Score = 32.3 bits (72), Expect = 1.8
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 4/108 (3%)
Query: 406 GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQY 465
G IFV + G A G L GD IL +NG N + A ++++ + +V
Sbjct: 324 GSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
Query: 466 RPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYD 513
++ ++D ++ + S + S E+R Y DYD
Sbjct: 384 DSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQY----SDYD 427
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 125 bits (315), Expect = 1e-28
Identities = 105/353 (29%), Positives = 155/353 (43%), Gaps = 69/353 (19%)
Query: 135 ERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEV 194
++ GLG SI G +D G+F++ I+ GG A DGRL D +L VN DV
Sbjct: 1730 KKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNA 1783
Query: 195 VHSRAVEALKEA-GPVVRLVVRRRQPPPETIME-----------------VNLLKGPK-G 235
LK + G + +E V + KGP
Sbjct: 1784 TQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS 1843
Query: 236 LGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAV 295
LG SIAGG+G+ GD I+I + G A + +L++GDR++ + T+ + + H +AV
Sbjct: 1844 LGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
Query: 296 ASLKNTSDMVYLKVAKPGSLHL--NDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK 353
LKN S + ++V G + + P + +FT L + I + LG
Sbjct: 1902 NLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDD----LG----- 1952
Query: 354 VSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEG----I 409
PPQ + I L +G GLGF+IVGG I
Sbjct: 1953 -----PPQC----------------------KSITLERGPDGLGFSIVGGYGSPHGDLPI 1985
Query: 410 FVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
+V + A G A G L+RGD+I++VNG +L THE+A A LKR +VT++
Sbjct: 1986 YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
Score = 117 bits (292), Expect = 6e-26
Identities = 121/423 (28%), Positives = 180/423 (42%), Gaps = 97/423 (22%)
Query: 56 SQTLPSQAGATPTPR---TKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWP---EC 109
SQ +PS AGA + +++ ++P P + STP + S P+ P C
Sbjct: 1567 SQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGC 1626
Query: 110 TCTNRDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGG 169
T I + +G +GLG SI GG D I I ++ G
Sbjct: 1627 ETT-------------------IEISKGRTGLGLSIVGGSDTLL----GAIIIHEVYEEG 1663
Query: 170 AAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPE-----TI 224
AA DGRL D +L VN +D+ + H A+ L++ VRL + R + P +
Sbjct: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT 1723
Query: 225 MEVNLLKGP-KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
+ + L K P KGLG SI G D ++++ I++GG A DGRL GD++L VN
Sbjct: 1724 LTIELQKKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNG 1777
Query: 284 TNLQDVRH--EEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHN 341
+DVR+ +EAVA+L S+ GS L+ P +ST +L
Sbjct: 1778 ---EDVRNATQEAVAALLKVSE---------GS--LSSFTFPLSGSSTSESLE------- 1816
Query: 342 SSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGST-GLGFNI 400
S ++ LA E + R + + KG T LG +I
Sbjct: 1817 --------------------------SSSKKNALASE--IQGLRTVEMKKGPTDSLGISI 1848
Query: 401 VGGEDGE----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAG 456
GG IF++ + G A + +LR GDRI+++ G + TH QA LK A
Sbjct: 1849 AGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAS 1908
Query: 457 QSV 459
S+
Sbjct: 1909 GSI 1911
Score = 115 bits (287), Expect = 2e-25
Identities = 100/385 (25%), Positives = 163/385 (42%), Gaps = 63/385 (16%)
Query: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
E I L SGLGF I GG G+ + I+PGG A GRL D +L++ +
Sbjct: 256 ETIELVNDGSGLGFGIIGG-------KATGVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
Query: 190 DVSEVVHSRAVEALKEAGPVVRLVVRR-----RQPP--------------PET------- 223
D++ + + + L++ G V+L++ R R P PE
Sbjct: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368
Query: 224 ------IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDR 277
+V L K +GLG +IAG IG++ + + I++ I + A + DGR+QIGD+
Sbjct: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQ 427
Query: 278 LLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADN- 336
++AV+ TNLQ +++AV L++T V L + + G ++ + D N
Sbjct: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487
Query: 337 ---HISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGS 393
++ +L + + P + P + I E+ +E + +
Sbjct: 488 SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEE---IEDAQKQEAALLTKWQRI 544
Query: 394 TGLGFNIV-------GGEDGEGI---------FVSFILAGGPADLSGELRRGDRILSVNG 437
G+ + IV G GI F+ +L GP SG+L GD +L VNG
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNG 604
Query: 438 VNLRNATHEQAAAALKRAGQSVTIV 462
+ L H+ LK VT+V
Sbjct: 605 ITLLGENHQDVVNILKELPIEVTMV 629
Score = 107 bits (268), Expect = 3e-23
Identities = 74/200 (37%), Positives = 98/200 (49%), Gaps = 35/200 (17%)
Query: 141 LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAV 200
LG SIAGG+ +P D IFI + P G AA +L V D ++ + + H++AV
Sbjct: 1844 LGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
Query: 201 EALKEA----------GPVVRLVVRRRQPP---------------------PETIMEVNL 229
LK A G V +V +Q P P + L
Sbjct: 1902 NLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITL 1961
Query: 230 LKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDV 289
+GP GLGFSI GG G+ H GD IY+ + GAA +DGRL+ GD+++AVN +L+ V
Sbjct: 1962 ERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGV 2019
Query: 290 RHEEAVASLKNTSDMVYLKV 309
HEEAVA LK T V L V
Sbjct: 2020 THEEAVAILKRTKGTVTLMV 2039
Score = 106 bits (264), Expect = 1e-22
Identities = 108/386 (27%), Positives = 161/386 (41%), Gaps = 65/386 (16%)
Query: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
I LE+G+SGLG S+AG D + +FI I P GAA DGRL + D +L +N +
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 192 SEVVHSRAVEALKEAGPVVRLVVRRR---------------QPPPETI-------MEVNL 229
H A +K A V+++ R +P P E +
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466
Query: 230 LKGPKGLGFSIAGGIGNQHIPGD--------------NSIYITKIIEGGAAQKDGRLQIG 275
+ S + + +P D + + I + E G A DGRL++G
Sbjct: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVG 1526
Query: 276 DRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALAD 335
D++LAV++ + E+ ++ LK V L ++H + P A A A
Sbjct: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKL------TIHAEN---PDSQAVPSAAGAA 1577
Query: 336 NHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTRE-----PRKIILH 390
+ NSS + P P + T S P + A + T I +
Sbjct: 1578 SGEKKNSSQSLMVPQSGS---PEPESIRNTSRSSTPA-IFASDPATCPIIPGCETTIEIS 1633
Query: 391 KGSTGLGFNIVGGEDG--EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448
KG TGLG +IVGG D I + + G A G L GD+IL VNG++LR ATH++A
Sbjct: 1634 KGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEA 1693
Query: 449 AAALKRAGQSVTIV-----AQYRPEE 469
L++ Q V + A Y+ EE
Sbjct: 1694 INVLRQTPQRVRLTLYRDEAPYKEEE 1719
Score = 104 bits (259), Expect = 4e-22
Identities = 101/408 (24%), Positives = 166/408 (40%), Gaps = 85/408 (20%)
Query: 92 GKSTPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFKYEEI--VLERGNSGLGFSIAGGI 149
G P +NG P C D ++Q+ + ++ E+ +L+ + GLGFS+ G
Sbjct: 107 GPGIPHINGK-----PAC-----DEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLR 156
Query: 150 DNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE-VVHSRAVEALKEAGP 208
+ GIF+ +I G A DGRL D +L +N + + + H +A+ L++A
Sbjct: 157 SENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKD 214
Query: 209 VVRLVVRRRQPPP-------------------------ETIMEVNLLKGPKGLGFSIAGG 243
V+LV+ R P + + + L+ GLGF I GG
Sbjct: 215 TVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG 274
Query: 244 IGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSD 303
+ + I+ GG A + GRL GD +L + +T+L + E+ L+ +
Sbjct: 275 KA-------TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGN 327
Query: 304 MVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVP 363
V L +A+ + + AP T ++ +P P
Sbjct: 328 RVKLMIARGA---IEERTAPTALGITLSS-------------------------SPTSTP 359
Query: 364 PTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVG--GE---DGEGIFVSFILAGG 418
R + E F E L K GLG I G G+ + GIFV I
Sbjct: 360 ELRVDASTQKGEESETFDVE-----LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSS 414
Query: 419 PADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYR 466
+ G ++ GD+I++V+G NL+ T++QA L+ GQ+V + R
Sbjct: 415 AVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
Score = 97.4 bits (241), Expect = 5e-20
Identities = 85/298 (28%), Positives = 143/298 (47%), Gaps = 46/298 (15%)
Query: 227 VNLLKGPKGLGFSIAG---GIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
+N+ KG LG +++ G+G + + II GGA +DGR+ IGD +L++N
Sbjct: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
Query: 284 TNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSS 343
+ V + +A A L+ S + + Y P ++ F IS
Sbjct: 1060 ESTISVTNAQARAMLRRHSLI---------GPDIKITYVPAEHLEEFK------ISLGQQ 1104
Query: 344 LGYLGAVESKVSYPAP--PQVPPTRYSPIPRHMLAEEDFTR--EPRKIIL-HKGSTGLGF 398
G + A++ SY P++P L ++ +PR++ L + S LG
Sbjct: 1105 SGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGI 1164
Query: 399 NIVGGE-------DGE---GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448
+IVGG +GE GIF+ +L PA +G L+ GDRI+ V+G++LR+A+HEQA
Sbjct: 1165 SIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQA 1224
Query: 449 AAALKRAGQSVTIVAQ---YRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRS 503
A+++AG V + Q RP + S S +H+L + SS + + SL+ + ++
Sbjct: 1225 VEAIRKAGNPVVFMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
Score = 82.8 bits (203), Expect = 1e-15
Identities = 74/279 (26%), Positives = 125/279 (44%), Gaps = 45/279 (16%)
Query: 227 VNLLKGP-KGLGFSIAGG--IGNQHIPGD--NSIYITKIIEGGAAQKDGRLQIGDRLLAV 281
V L + P K LG SI GG +G++ G+ I+I ++E A K+G L+ GDR++ V
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 282 NNTNLQDVRHEEAVASLKNTSDMVYLKVAK----------PGSLHLNDMYAPPDYASTFT 331
+ +L+D HE+AV +++ + V V P LH ++Y +++ST
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLH--NLYPKYNFSSTNP 1269
Query: 332 ALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRY------------SPIPRHMLAEED 379
I+ + + + K + P PP+ + S I + + E++
Sbjct: 1270 FADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDE 1329
Query: 380 F--------------TREPRKIILHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLS 423
F T E I L KG +GLG ++ G +D +F+ I G A
Sbjct: 1330 FGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKD 1389
Query: 424 GELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
G L+ D +L +NG L +H+ A++ +K A V I+
Sbjct: 1390 GRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKII 1428
Score = 76.3 bits (186), Expect = 1e-13
Identities = 98/387 (25%), Positives = 159/387 (41%), Gaps = 71/387 (18%)
Query: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
+ I LE+G+ GLGFSI D P P I I ++PGG A DGRL D ++ VN+V
Sbjct: 699 QHIELEKGSKGLGFSILDYQD-PIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757
Query: 190 DVSEVVHSRAVEALKEA-GPVVRLVVRRRQP-----------------PPETIMEVNL-- 229
++ AVEALK A VR+ V + P PP + E L
Sbjct: 758 NLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLAD 817
Query: 230 ---------LKGPKGLGFSIAGGIGNQHIPGDNSIYITK---IIEGGAAQKDGRLQIGDR 277
L G + + P ++SIY T+ + G++ DG L G
Sbjct: 818 KPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDG-LNYGSS 876
Query: 278 LLA------VNNT---------NLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYA 322
L + + N+ +L+++ + + + V + + +ND Y
Sbjct: 877 LPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTIND-YT 935
Query: 323 PPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAP-PQVPPTRYSPIPRHMLAE---- 377
P + A+ + N+ + + S+V A P V P ++L +
Sbjct: 936 PAN------AIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLA 989
Query: 378 --------EDFTRE--PRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELR 427
++ ++E R I + KG++ LG + +DG G+ V I+ GG G +
Sbjct: 990 CNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIA 1049
Query: 428 RGDRILSVNGVNLRNATHEQAAAALKR 454
GD ILS+N + + T+ QA A L+R
Sbjct: 1050 IGDCILSINEESTISVTNAQARAMLRR 1076
Score = 70.5 bits (171), Expect = 6e-12
Identities = 89/330 (26%), Positives = 125/330 (37%), Gaps = 87/330 (26%)
Query: 138 NSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHS 197
NSGLG S+ + + FI ++P G G+L D +L VN + + H
Sbjct: 562 NSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQ 613
Query: 198 RAVEALKEAGPVVRLVVRRRQPPPETIMEVNLL---------KGPKGLGFSIAGG----- 243
V LKE V +V RR PP T E++ L K LG I
Sbjct: 614 DVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDP 673
Query: 244 ----------------------IGNQHI---------------------PGDNSIYITKI 260
G QHI P I I +
Sbjct: 674 VLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSL 733
Query: 261 IEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT-SDMVYLKVAKPGSLH--- 316
+ GG A+KDGRL GDRL+ VN+ NL++ EEAV +LK S V + VAKP L
Sbjct: 734 VPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEE 793
Query: 317 -----LNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIP 371
D + P ++ LAD + + L +G ++ + + + P YSP
Sbjct: 794 GYVSAKEDSFLYPPHSCEEAGLADKPL-FRADLALVGTNDADLVDESTFESP---YSP-- 847
Query: 372 RHMLAEED--FTREPRKIILHKGSTGLGFN 399
E D ++ + + LH S G G N
Sbjct: 848 -----ENDSIYSTQASILSLHGSSCGDGLN 872
Score = 64.7 bits (156), Expect = 3e-10
Identities = 66/255 (25%), Positives = 104/255 (40%), Gaps = 32/255 (12%)
Query: 224 IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
+ V+ GLG S+ +G+ +I ++ G G+L GD LL VN
Sbjct: 553 VAHVSKFSENSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNG 604
Query: 284 TNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTAL--ADNHISHN 341
L H++ V LK V + + PP S +L D ++
Sbjct: 605 ITLLGENHQDVVNILKELPIEVTMVCCR--------RTVPPTTQSELDSLDLCDIELTEK 656
Query: 342 SSLG---YLGAVESKVSYPAPPQV-PPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLG 397
+ ++G+ E++ A T P M + + I L KGS GLG
Sbjct: 657 PHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAM-----WEAGIQHIELEKGSKGLG 711
Query: 398 FNIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 452
F+I+ +D I + ++ GG A+ G L GDR++ VN VNL N++ E+A AL
Sbjct: 712 FSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL 771
Query: 453 KRAGQSVTIVAQYRP 467
K A + +P
Sbjct: 772 KGAPSGTVRIGVAKP 786
Score = 62.4 bits (150), Expect = 2e-09
Identities = 36/85 (42%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
+ I LERG GLGFSI GG +PH D I++ + GAA+ DGRL D ++ VN
Sbjct: 1957 KSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2014
Query: 190 DVSEVVHSRAVEALKEAGPVVRLVV 214
+ V H AV LK V L+V
Sbjct: 2015 SLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 58.9 bits (141), Expect = 2e-08
Identities = 66/264 (25%), Positives = 98/264 (37%), Gaps = 27/264 (10%)
Query: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
+ L KG GLG S+AG + S++I I GAA KDGRLQI D LL +N L
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 287 QDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGY 346
H+ A + +K V + + +N M P
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDA-VNQMAVCPG--------------------- 1444
Query: 347 LGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG 406
AVE S Q T + + + + + L K GLG I +
Sbjct: 1445 -NAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTL 1503
Query: 407 EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYR 466
G+ + + G A G L+ GD+IL+V+ + E+ + LK A +V +
Sbjct: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAE 1563
Query: 467 PEEYSRFESKIHDLREQMMNSSMS 490
+ S + NSS S
Sbjct: 1564 NPDSQAVPSAAGAASGEKKNSSQS 1587
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/84 (30%), Positives = 45/84 (53%), Gaps = 9/84 (10%)
Query: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
I + +GNS LG +++ D G+ + II GGA + DGR+ + DC+L +NE
Sbjct: 1009 INIAKGNSSLGMTVSAN------KDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
Query: 192 SEVVHSRAVEALKE---AGPVVRL 212
V +++A L+ GP +++
Sbjct: 1063 ISVTNAQARAMLRRHSLIGPDIKI 1086
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 9/83 (10%)
Query: 138 NSGLGFSIAGG------IDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
+ LG SI GG + N V GIFI ++ A +G L D ++ V+ +D+
Sbjct: 1159 SKSLGISIVGGRGMGSRLSNGEVMR--GIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
Query: 192 SEVVHSRAVEALKEAG-PVVRLV 213
+ H +AVEA+++AG PVV +V
Sbjct: 1217 RDASHEQAVEAIRKAGNPVVFMV 1239
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 122 bits (305), Expect = 2e-27
Identities = 107/339 (31%), Positives = 158/339 (46%), Gaps = 35/339 (10%)
Query: 130 EEIVLE--RGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 187
+E+++E +G SGLG SI GG D P I I ++ GAAA DGRL D +L VN
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
Query: 188 EVDVSEVVHSRAVEALKEAGPVVRLVVRR-----RQPPPETIMEVNLLK-GPKGLGFSIA 241
VD+ H A+ AL++ VRLVV R R I V+L K +GLG SI
Sbjct: 1490 GVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIV 1549
Query: 242 GGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT 301
G + ++I+ I++GGAA DGRL GD++L+VN ++++ E LK
Sbjct: 1550 GKRNG------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603
Query: 302 SDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQ 361
+V L++ + + S T ++ S S+ + V
Sbjct: 1604 QGLVQLEIGR---------LRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNL 1654
Query: 362 VPPTRYSPIPRHMLAEEDFTREPRKIILHKG-STGLGFNIVGGEDGE----GIFVSFILA 416
V R S P + D EPR + +++ S LG +I GG +F++ I A
Sbjct: 1655 VGTKRVSD-PSQKNSGTDM--EPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQA 1711
Query: 417 GGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 455
G A + +L+ GDRI+S+NG L +H LK A
Sbjct: 1712 SGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 106 bits (264), Expect = 1e-22
Identities = 96/364 (26%), Positives = 152/364 (41%), Gaps = 85/364 (23%)
Query: 130 EEIVLERGNSG-LGFSIA-------GGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVND 181
E I +ER ++G LGFS+ G +D IF+ + PG A D RL ND
Sbjct: 133 EYIDIERPSTGGLGFSVVALRSQNLGKVD---------IFVKDVQPGSVADRDQRLKEND 183
Query: 182 CVLRVNEVDVSE-VVHSRAVEALKEAGPVVRLVVRRR--------------QPPPETIM- 225
+L +N + + + H +A+ L++ +RL+V R PET+
Sbjct: 184 QILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCW 243
Query: 226 ----EVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAV 281
EV L+ GLGF I GG + + + I+ GG A +DGRLQ GD +L +
Sbjct: 244 GHVEEVELINDGSGLGFGIVGG-------KTSGVVVRTIVPGGLADRDGRLQTGDHILKI 296
Query: 282 NNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHN 341
TN+Q + E+ L+N + V + VA+
Sbjct: 297 GGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----------------------------- 327
Query: 342 SSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIV 401
A + V+ PAP +P + + ++ ++ K LG IV
Sbjct: 328 ------PAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIV 381
Query: 402 G----GEDGE--GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 455
G GE GI+V I+ G A +G ++ D+I++V+GVN++ + L+ A
Sbjct: 382 GYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNA 441
Query: 456 GQSV 459
GQ V
Sbjct: 442 GQVV 445
Score = 97.1 bits (240), Expect = 6e-20
Identities = 65/230 (28%), Positives = 101/230 (43%), Gaps = 37/230 (16%)
Query: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
EE+ L SGLGF I GG + G+ + I+PGG A DGRL D +L++
Sbjct: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
Query: 190 DVSEVVHSRAVEALKEAGPVVRLVVRRRQ-------PPPETIMEVNL----LKGP----- 233
+V + + + L+ G VR++V R PP + V L KGP
Sbjct: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
Query: 234 --------------KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLL 279
+ LG I G +G H + IY+ II G AA +G +Q+ D+++
Sbjct: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
Query: 280 AVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYAST 329
AV+ N+Q + + V L+N +V+L + + + PP T
Sbjct: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGT 469
Score = 91.3 bits (225), Expect = 3e-18
Identities = 87/301 (28%), Positives = 127/301 (42%), Gaps = 49/301 (16%)
Query: 221 PETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLA 280
P + + L K GLG S+AG + SI++ I G A DGR++IGD LL
Sbjct: 1234 PGELHIIELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLE 1289
Query: 281 VNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAP-PDYASTFTALADNHIS 339
+NN L H+ A A +K V L + P P +S+ +++ D +
Sbjct: 1290 INNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGT 1349
Query: 340 HNSSLGYLGAVESKVSY------------PAPPQVPPTRYS---------PIPRHMLAEE 378
S G+VE + Q PT+ S P + +
Sbjct: 1350 EPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDA 1409
Query: 379 DFTR--------------------EPRKIILHKGSTGLGFNIVGGEDG--EGIFVSFILA 416
DFT + I + KG +GLG +IVGG+D I + +
Sbjct: 1410 DFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYE 1469
Query: 417 GGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESK 476
G A G L GD+IL VNGV+LRN++HE+A AL++ Q V +V YR E + R E
Sbjct: 1470 EGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEEN 1528
Query: 477 I 477
+
Sbjct: 1529 L 1529
Score = 89.0 bits (219), Expect = 2e-17
Identities = 70/234 (29%), Positives = 113/234 (48%), Gaps = 50/234 (21%)
Query: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL-QDVRHEE 293
GLGFS+ + +Q++ G I++ + G A +D RL+ D++LA+N+T L Q++ H++
Sbjct: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
Query: 294 AVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK 353
A+A L+ T+ + L VA+ +H +ST ++L D + G++ VE
Sbjct: 202 AIALLQQTTGSLRLIVARE-PVHTK--------SSTSSSLNDTTLPETVCWGHVEEVE-- 250
Query: 354 VSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSF 413
+++ GS GLGF IVGG+ G+ V
Sbjct: 251 ----------------------------------LINDGS-GLGFGIVGGKTS-GVVVRT 274
Query: 414 ILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRP 467
I+ GG AD G L+ GD IL + G N++ T EQ A L+ G SV ++ P
Sbjct: 275 IVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 76.6 bits (187), Expect = 8e-14
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 37/261 (14%)
Query: 227 VNLLKGPK-GLGFSIAGGI-------GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278
V + + P LG SI GG + + G I+I +++E A K L+ GD++
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 279 LAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHI 338
L V+ +LQ+ H EAV ++KN + V V SL P + N I
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ---SLSSTPRVIPNVHNKA------NKI 1176
Query: 339 SHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEE---------------DFTRE 383
+ N + E + PP P Y + E D E
Sbjct: 1177 TGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGE 1236
Query: 384 PRKIILHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
I L K GLG ++ G +D IFV I GPA G +R GD +L +N L
Sbjct: 1237 LHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILY 1296
Query: 442 NATHEQAAAALKRAGQSVTIV 462
+H+ A+A +K A V +V
Sbjct: 1297 GRSHQNASAIIKTAPSKVKLV 1317
Score = 73.6 bits (179), Expect = 7e-13
Identities = 97/403 (24%), Positives = 152/403 (37%), Gaps = 113/403 (28%)
Query: 77 PTGRDVGPVPPKPVP-GKSTPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFKYEEIVLE 135
P G D+ PP P + P + GP ++ +E N E+V +
Sbjct: 328 PAG-DISVTPPAPAALPVALPTVASKGPG-------SDSSLFETYN--------VELVRK 371
Query: 136 RGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVV 195
G S LG I G + H + GI++ IIPG AA +G + VND ++ V+ V++
Sbjct: 372 DGQS-LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFA 430
Query: 196 HSRAVEALKEAGPVVRLVVRRR---------QPPPETIMEVNLLKGPKGLGFSIAGGIGN 246
+ VE L+ AG VV L + RR +PP + V LK P
Sbjct: 431 NHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPP------------- 477
Query: 247 QHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVY 306
++++T +E N + +D +E + +LKN +
Sbjct: 478 -------ALFLTGAVE-----------------TETNVDGEDEEIKERIDTLKNDNIQAL 513
Query: 307 LKVAKPGSLHLNDMYA------PPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPP 360
K+ K N++ + PDY A D I+ ++ L
Sbjct: 514 EKLEKVPDSPENELKSRWENLLGPDY-EVMVATLDTQIADDAEL---------------- 556
Query: 361 QVPPTRYSP-IPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGP 419
+YS +P H L LG V DG ++S I++GGP
Sbjct: 557 ----QKYSKLLPIHTLR-------------------LGVE-VDSFDGHH-YISSIVSGGP 591
Query: 420 ADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
D G L+ D +L VNG+ L + +A + LK T+V
Sbjct: 592 VDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/91 (42%), Positives = 54/91 (59%), Gaps = 6/91 (6%)
Query: 219 PPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278
P E I+E++ KG GLG SI GG N+I I ++ E GAA +DGRL GD++
Sbjct: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
Query: 279 LAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
L VN +L++ HEEA+ +L+ T V L V
Sbjct: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVV 1516
Score = 62.8 bits (151), Expect = 1e-09
Identities = 33/87 (37%), Positives = 50/87 (57%), Gaps = 10/87 (11%)
Query: 388 ILHKGSTGLGFNIVGG----------EDGEGIFVSFILAGGPADLSGELRRGDRILSVNG 437
I + + LG +IVGG E+ +GIF+ +L PA + L+ GD+IL V+G
Sbjct: 1071 IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSG 1130
Query: 438 VNLRNATHEQAAAALKRAGQSVTIVAQ 464
V+L+NA+H +A A+K AG V + Q
Sbjct: 1131 VDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 62/229 (27%)
Query: 135 ERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEV 194
++ GLG SI G + G+FI+ I+ GGAA +DGRL D +L VN D+
Sbjct: 1538 KKAGRGLGLSIVGKRNGS------GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
Query: 195 VHSRAVEALKEA-----------------------------------------GPVV--- 210
LK A PV+
Sbjct: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
Query: 211 -RLVVRRRQPPPE-----TIMEVNLLKGPK----GLGFSIAGGIGNQHIPGDNSIYITKI 260
LV +R P T ME ++ + LG SIAGG G+ GD ++I I
Sbjct: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
Query: 261 IEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
G A + +L++GDR++++N L + H + V LKN + L+V
Sbjct: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758
Score = 56.6 bits (135), Expect = 9e-08
Identities = 61/257 (23%), Positives = 98/257 (38%), Gaps = 49/257 (19%)
Query: 252 DNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK 311
D YI+ I+ GG G LQ D LL VN L EAV+ LK L +
Sbjct: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
Query: 312 PGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIP 371
+D + + T T+L + + HN + + +++ +P
Sbjct: 638 ---RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSP------------ 682
Query: 372 RHMLAEEDFTREPRKIILHKGSTGLGFNIVGGED-----GEGIFVSFILAGGPADLSGEL 426
E + + L K GLGF+I+ +D I + ++A G A+ SG L
Sbjct: 683 -----------EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGL 731
Query: 427 RRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRP------------------E 468
GDR++SVN L N + +A LK + + +P E
Sbjct: 732 LPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNE 791
Query: 469 EYSRFESKIHDLREQMM 485
+ + F IHD+ ++
Sbjct: 792 DKTEFSGTIHDINSSLI 808
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/192 (29%), Positives = 79/192 (41%), Gaps = 41/192 (21%)
Query: 161 FITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRR--- 217
+I+ I+ GG G L D +L VN + + AV LKE P LV RR
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 218 ------QPP------PETIME------------------------VNLLKGPKGLGFSIA 241
+P PET ++ V L+K KGLGFSI
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
Query: 242 GGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT 301
+ P + I I ++ G A++ G L GDRL++VN L + EAV LK
Sbjct: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
Query: 302 -SDMVYLKVAKP 312
+V+L + KP
Sbjct: 761 PPGLVHLGICKP 772
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/102 (32%), Positives = 46/102 (45%), Gaps = 8/102 (7%)
Query: 133 VLERGNSGLGFSIAGG------IDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
+ N LG SI GG + N + GIFI +++ A L D +L V
Sbjct: 1071 IFREPNVSLGISIVGGQTVIKRLKNGE--ELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
Query: 187 NEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVN 228
+ VD+ HS AVEA+K AG V +V+ P I V+
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVH 1170
Score = 33.1 bits (74), Expect = 1.1
Identities = 26/77 (33%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
+ L + GLGFSI D P P I I ++ G A G L D ++ VNE +
Sbjct: 687 VELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745
Query: 192 SEVVHSRAVEALKEAGP 208
+ AVE LK P
Sbjct: 746 DNTSLAEAVEILKAVPP 762
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,743,437
Number of Sequences: 37866
Number of extensions: 1788760
Number of successful extensions: 9279
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 203
Number of HSP's that attempted gapping in prelim test: 7654
Number of HSP's gapped (non-prelim): 1357
length of query: 817
length of database: 18,247,518
effective HSP length: 111
effective length of query: 706
effective length of database: 14,044,392
effective search space: 9915340752
effective search space used: 9915340752
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.